Epithelial-mesenchymal interaction protects normal colonocytes from 4-HNE-induced phenotypic transformation

ConclusionsDuring the exposure phase, the epithelial-mesenchymal interaction protected colonocytes from 4-HNE-induced phenotypic transformation via activation of the BMP pathway. This intercellular dialogue also limited the ability of fibroblasts to subsequently promote colonocyte-anchorage-independent growth. In contrast, fibroblasts pre-exposed to 4-HNE in monoculture strongly increased the ability of Co(m) colonocytes to form colonies.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research