Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer

Conclusions: The newly developed radiomic signature was a powerful predictor of LN metastasis and the radiomics nomogram could facilitate the preoperative individualized prediction of LN status. Introduction Gastric cancer (GC) is one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide (1). Accurate evaluation of lymph node metastasis (LNM) status in GC patients is vital for prognosis and treatment decisions (2–4). Some histopathologic factors and biomarkers (e.g., lymphatic invasion, matrix metalloproteinase-2) are found to be able to predict LNM in GC, but most of them are only available after surgery (5–9). Preoperative evaluation of LNM could provide meaningful messages for determining the options of adjuvant therapy and the adequacy of surgical resection, hence assisting in pretreatment decision making (2–4). D2 gastrectomy was accepted as the standard surgery, especially advanced GC (10). Recently, surgeons think of endoscopic resection as the best choice for early GC without LNM, on account of more postoperative complication and mortality of D2 gastrectomy (4). Besides, clinical node staging is often under estimating the higher node staging seen by pathology (3, 4). Therefore, accurate preoperative predictions of LNM status are vital for GC patients, especially at the early stage. Recent studies showed that several serum markers (e.g., serum human apurinic/apyrimidinic endonuclease 1, circu...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research