Radiomics Signature on Computed Tomography Imaging: Association With Lymph Node Metastasis in Patients With Gastric Cancer

Conclusions: The newly developed radiomic signature was a powerful predictor of LN metastasis and the radiomics nomogram could facilitate the preoperative individualized prediction of LN status. Introduction Gastric cancer (GC) is one of the most common malignant tumors and the second leading cause of cancer-related deaths worldwide (1). Accurate evaluation of lymph node metastasis (LNM) status in GC patients is vital for prognosis and treatment decisions (2–4). Some histopathologic factors and biomarkers (e.g., lymphatic invasion, matrix metalloproteinase-2) are found to be able to predict LNM in GC, but most of them are only available after surgery (5–9). Preoperative evaluation of LNM could provide meaningful messages for determining the options of adjuvant therapy and the adequacy of surgical resection, hence assisting in pretreatment decision making (2–4). D2 gastrectomy was accepted as the standard surgery, especially advanced GC (10). Recently, surgeons think of endoscopic resection as the best choice for early GC without LNM, on account of more postoperative complication and mortality of D2 gastrectomy (4). Besides, clinical node staging is often under estimating the higher node staging seen by pathology (3, 4). Therefore, accurate preoperative predictions of LNM status are vital for GC patients, especially at the early stage. Recent studies showed that several serum markers (e.g., serum human apurinic/apyrimidinic endonuclease 1, circulating...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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CONCLUSION: This study confirmed published results that labour progresses more slowly as maternal BMI increases. The study was performed in a centre with a specialized BMI pregnancy clinic; thus weight gain adherence, awareness of labour differences, and patient counselling may have contributed to low Caesarean section rates. Obstetric care providers should consider differences in maternal BMI in labour progression before undertaking a potentially premature Caesarean birth, especially in primiparas. PMID: 31324481 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
CONCLUSION: In patients with cardiogenic shock after delivery, early transthoracic echocardiography is a non-invasive tool that can rapidly narrow the differential diagnosis. PMID: 31324480 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
In this study, the effects of dietary administration of lactic acid bacteria (LAB) (Enterococcus faecalis Y17 and Pediococcus pentosaceus G11) on growth performance and immune responses of mud crab were assessed. Both strains (Y17 and G11) showed an inhibitory activity against bacterial pathogens (Aeromonas hydrophila, Vibrio parahaemolyticus, Vibrio alginolyticus, Staphylococcus aureus, and β Streptococcus), and a wide pH tolerance range of 2–10. In vivo, mud crabs were fed a control diet and experimental diets supplemented with 109 cfu g−1 diet either Y17 or G11 for 6 weeks before subjecting to a cha...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: December 2019Source: Protein Expression and Purification, Volume 164Author(s): Elisabeth Graeber, Volodymyr M. KorkhovAbstractThe translocator protein TSPO is in an important diagnostic and therapeutic target in a range of pathologies, including neuroinflammation and cancer. Despite the availability of several structures of TSPO homologues, our understanding of the molecular determinants that govern high-affinity interactions of TSPO with its ligands is incomplete. Here, in order to decipher the key structural elements of TSPO responsible for interactions with its ligands, we designed a panel of chimeric ...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
This is a guest post from one of our patients. She is 32 and recently froze her eggs at Malpani Infertility ClinicOur 20 ’s and early 30's may be theeasiest time to have a baby but it's not always the best time - for a lot of good reasons. We are at the top of our career and want to grow professionally; we want to prepare emotionally and financially to be parents ; and we are unwilling to settle for Mr. RightNow instead of Mr. Right.The problem is that the biological clock is ticking on - and we can hear it loud and clear ! The good news is that with a little medical help , we can freeze time , to plan for the future...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
ConclusionLicensed drivers with ASD were found to allocate visual attention differently compared to licensed drivers without ASD. Poor scanning patterns with an over-focus on the road ahead and less scanning of the road side and periphery may possibly result in unsafe driving. However, risk-taking behaviour was not prevalent in these drivers. Effective visual scanning strategies could be incorporated in the driver training of individuals with ASD.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Publication date: Available online 21 July 2019Source: European UrologyAuthor(s): Marshall Strother, Alexander Kutikov
Source: European Urology - Category: Urology & Nephrology Source Type: research
I’ve scanned through and haven’t found a post that seems to fully answer my question. I have about $150,00 in student loans left, all of which are federal. When I first graduated I picked the 25 year extended payment plan. I decided not to do IBR because the payments were about the same and I assumed my income would increase. Since this will now be year 3 without a raise or bonus, does it make sense to backtrack and sign up for IBR? I picked the plan I did with the intent to pay extra and... IBR? Loan advice?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pharmacy Source Type: forums
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
young female, known to have a metastatic breast cancer, since 5 years. In 2017, she developed secondary lesions in the brain with positive CSF. She receives 30Gy/10 fr whole brain radiation, with intra-thecal chemotherapy. A month ago, she developed gait disturbances with blurred speech an hemifacial paresia. Brain MRI showed a solitary secondary lesion, 1.5 cm involving the left middle cerebral peduncle with extensive edema. No signs of meningeal disease. Pet CT : NED outside the brain... SRS for BS lesion: what dose?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
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