Antigen I/II Participates in the Interactions of Streptococcus suis Serotype 9 With Phagocytes and the Development of Systemic Disease

In conclusion, S. suis serotype 9 causes a systemic infection resulting in the development of clinical disease and host death. As with serotype 2, this infection is characterized by exacerbated inflammation induced by an uncontrolled and persistent bacterial presence in the systemic compartment. Not only does presence of AgI/II affect S. suis phagocytosis by promoting resistance to phagocytic cells, but it also participates in innate immune cell activation, and by consequence, inflammation. As such, S. suis serotype 9 AgI/II is an important factor involved in not only the initial steps of its pathogenesis in pigs, but also for virulence during systemic infection and development of disease in a mouse model. In fact, this is the first study to describe a role of an AgI/II family member in systemic bacterial disease. Ethics Statement This study was carried out in accordance with the recommendations of the guidelines and policies of the Canadian Council on Animal Care and the principles set forth in the Guide for the Care and Use of Laboratory Animals. The protocols and procedures were approved by the Animal Welfare Committee of the University of Montreal (permit number Rech-1570). Author Contributions J-PA, MS, and MG conceived and designed the experiments. J-PA and A-CB performed the experiments. J-PA and MG analyzed the data. J-PA, MS, and MG contributed to the writing of the manuscript. All authors have read and approved the manuscript. Funding This study was funded by ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research