Antigen I/II Participates in the Interactions of Streptococcus suis Serotype 9 With Phagocytes and the Development of Systemic Disease

Antigen I/II Participates in the Interactions of Streptococcus suis Serotype 9 With Phagocytes and the Development of Systemic Disease Jean-Philippe Auger, Anaïs-Christelle Boa, Mariela Segura and Marcelo Gottschalk* Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Disease Research Center (CRIPA), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada Streptococcus suis is an important porcine bacterial pathogen and a zoonotic agent causing a variety of pathologies including sudden death, septic shock, and meningitis. Though serotype 2 is the most studied serotype due to its presence worldwide, serotype 9 is responsible for the greatest number of porcine cases in Spain, the Netherlands, and Germany. Regardless of its increasing importance, very few studies have investigated S. suis serotype 9 virulence factors and pathogenesis. Antigens I/II (AgI/II) are multimodal adhesion proteins implicated in host respiratory tract and oral cavity persistence of various pathogenic human streptococci. It was recently demonstrated that AgI/II is involved in various bacterial functions for serotype 9, participating in the initial steps of the pathogenesis of the infection. However, its contribution to the systemic infection remains unknown. As such, we evaluated herein the role of the S. suis serotype 9 AgI/II in the interactions with phagocytes and the development of systemic disease in a mouse m...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

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This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Petra Juskova, Steven Schmitt, Lucas Armbrecht, Petra S Dittrich Microbial cells represent a standard production host for various important biotechnological products. Production yields can be increased by optimising strains, growth conditions and understanding deviations in production rates over time... The content of this RSS Feed (c) The Royal Society of Chemistry
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