The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves

Conclusion It was established that both the nerve excitation conduction and the transection of somatic nerves lead to profound changes in the lipid composition. Not only the number of phospholipids, but also the phospholipid fatty acid composition is changing. The key factors responsible for the detected changes are phospholipase A2 and phospholipase C activities. In the first place of the nerve fiber degenerative processes were both Ca 2+-dependent and Ca 2+-independent phospholipase A2 activation in the fiber’s distal part, which associated with of the axonal transport blocking. Another factor affecting the nerve excitability and the degenerative processes dynamics is the activation of the phosphoinositide’s metabolism of Revin et al. (1996, 2006). The differences and directions of changes in the amount of PI and DAG that we found during excitation and at the degeneration indicate disorders in the somatic nerves phosphoinositides metabolism and enzyme systems responsible for both the phosphorylation of individual forms of PI and its hydrolysis. One of the mechanisms of action of resveratrol on the nerve regeneration process is associated with its antioxidant ability, due to the leveling of the content of hydroxyl, superoxide and other radicals. All this is manifested in the protection of cell membranes from lipid peroxidation and DNA damage (Kovacic and Somanathan, 2010; Huang et al., 2014). Probably, changes in the content of PI and DAG, as well as the red...
Source: Frontiers in Physiology - Category: Physiology Source Type: research