Identification of a Novel Bcl-2 Inhibitor by Ligand-Based Screening and Investigation of Its Anti-cancer Effect on Human Breast Cancer Cells

In conclusion, we identified a novel Bcl-2 inhibitor by QSAR screening, which exerted significant cytotoxic activity in breast cancer cells through inducing mitochondria-mediated apoptosis. Introduction Apoptosis is a process of cellular suicide through which unwanted or unhealthy cells are eliminated during organism development or cellular stress (Reed, 2002; Fernald and Kurokawa, 2013). Deregulated apoptosis is a characteristic of cancers (Doi et al., 2012; Roizen, 2012). The B-cell lymphoma-2 (Bcl-2) family is composed of pro- and anti-apoptotic proteins, plays pivotal role in the mitochondrial pathway of apoptosis by promoting the release of cytochrome c and Smac (Second mitochondrial-derived activator of caspases) into the cytosol, resulting in caspase-dependent cell death (Day et al., 2008; Bai and Wang, 2013). The pro-apoptotic proteins of Bcl-2 family include Bak and Bax, the multi-domain proteins, and Bim, Bid, Puma, and Noxa, the BH3 domain only proteins (Fulda, 2013). The most prominent anti-apoptotic proteins contain Bcl-xl, Bcl-2, and Mcl-1 (Oltersdorf et al., 2005). The BH3-only proteins stimulate apoptosis either by interacting with Bak and Bax or by binding to the anti-apoptotic proteins to release Bax and Bak (Martin and Dowsett, 2013). Therefore, the cell survival or death is largely determined by the ratio of Bcl-2 family anti- and pro-apoptotic proteins. In most tumor tissues and cancer cell lines, the anti-apoptotic Bcl-2 proteins are frequently hig...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

This study examined whether age plays a role in the relationship between religiosity and adolescent major depressive episodes (MDEs). The 2012 National Survey on Drug Use and Health data was examined. Odds ratios were computed to determine if the association between religiosity and MDE differed based on age of adolescent among 12 –13-year-olds, 14–15-year-olds, and 16–17-year-olds. Results indicated that 9.7% of adolescents reported having an MDE within the past year. Past-year MDE did not differ based on religious attendance for any of the three age groups. However, 12–13- and 14–15-year-olds...
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research
This study contributes to the knowledge of, and possible reflections upon, the impact of physicians ’ personal beliefs and values on their attitudes toward important decisions in their patients’ lives.
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research
AbstractSpirituality is an important factor that may mediate the detrimental impacts of hemodialysis on mental health. Lack of research examining spirituality and mental health in the Arab world in general and Jordan in particular encouraged this research. The study examined levels of spirituality, depression and anxiety and explored the association between them among patients receiving hemodialysis treatment in Jordan. A cross-sectional design was used to recruit 202 patients receiving hemodialysis treatment. Self-administered questionnaires including spiritual well-being scale, depression and anxiety and a demographic da...
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research
This study focused on examining the effects of personality traits in moderating relationship between religiosity and mental health of university students. It was conducted on a sample of (N = 372) university students aged between 20 and 26 years equated to gender: 186 male and 186 female students at Bahauddin Zakariya University Multan. The religiosity, mental health and personality traits were measured by using the scale of Religiosity of Islam, Inventory of Mental Health and Bi g Five Inventory, respectively. The correlation analyses showed the significant relationship of religiosity with behavioral co...
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research
Publication date: September 2020Source: Biotechnology Reports, Volume 27Author(s): Parastoo Mojtahed Zadeh-Ardabilia, Sima Kianpour Rad
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
Publication date: 2020Source: Computational and Structural Biotechnology Journal, Volume 18Author(s): Zhilan Zhang, Lin Li, Mengyuan Li, Xiaosheng Wang
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Cancer-fighting Kronos and Spruce, targeting a serious hormonal condition, have a common investor in Omega Funds.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 18 September 2020Source: Physiology &BehaviorAuthor(s): V. Chubar, P. Luyten, L. Goossens, B. Bekaert, D. Bleys, B. Soenens, S. Claes
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 19 September 2020Source: Molecular Phylogenetics and EvolutionAuthor(s): Jun Chen, Yan-Fei Zeng, Da-Yong Zhang
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: Available online 18 September 2020Source: MethodsAuthor(s): James A. Broadbent, Mark R. Condina, Michelle L. Colgrave
Source: Methods - Category: Molecular Biology Source Type: research
More News: Academia | Academies | Acute Leukemia | Acute Myeloid Leukemia | Anesthesia | Anesthesiology | Biology | Biotechnology | Breast Cancer | Cancer | Cancer & Oncology | Cardiology | Chemistry | Chemotherapy | China Health | Chronic Leukemia | Chronic Lymphocytic Leukemia | Chronic Pain | Clinical Trials | Colorectal Cancer | Databases & Libraries | Depression | Dermatology | Docetaxel | Drugs & Pharmacology | Environmental Health | Grants | Heart | Heart Failure | Hematology | Learning | Leukemia | Lung Cancer | Lymphoma | Medical Ethics | Men | Merck | Milk | Mitochondria | Molecular Biology | Non-Small Cell Lung Cancer | OBGYN | Oral Cancer | Pain | Prostate Cancer | Reproduction Medicine | Science | Serbia Health | Skin | Statistics | Students | Study | Suicide | Taxotere | Thrombocytopenia | Toxicology | Training | Universities & Medical Training | USA Health