N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia

In conclusion, the high structural diversity of these compounds pinpoints the significant range of inhibition strategies that can be conceived to target the class I methyltransferases. Although the structural details of the various members of this family are unique, the success stories of drug design for several enzymes belonging to this family portends the likely achievement of discovering potent and selective inhibitors of METTL3/METTL14. Author Contributions AF and AP wrote the manuscript. ZI revised and edited manuscript and prepared figures. Funding This work was supported by Associazione Italiana Ricerca sul Cancro (AIRC) IG 17352 to AF, AIRC MFAG 20447 to AP and Progetti Ateneo Sapienza University of Rome to AF and AP. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. (2011) 7:885–7. doi: 10.1038/nchembio.687 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. (2013) 49:18–29. doi: 10.1016/j.molcel.2012.10.015 PubMed Abstract | CrossRef Full Text | Google Scholar ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 9 December 2019Source: European UrologyAuthor(s): Christian Radmayr
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionBreast pilonidal sinus is an extremely rare variant of the condition. It should be suspected on clinical examination. Surgical excision is the definitive treatment strategy.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionIndiana pouch is a successful continence urinary reservoir with a reproductible technique, however long-term observation is needed.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionGiven the increasing number of such surgeries performed the recognition of acute and chronic complications, and their optimal management is of great importance. Although performing a Roux-en-Y fistulojejunostomy was recommended in the literature, conservative and endoscopic treatment should be considered before.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present this case for the uniqueness of the bilateral ovarian pathology as well as to show that robotic-assisted resection of ovarian tumors in certain children is safe and feasible.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
ConclusionDirect-to-implant IBR after skin-sparing mastectomy is a viable option for breast cancer patients undergoing neoadjuvant chemotherapy.ResumenIntroducciónLa reconstrucción inmediata (RMI) tras mastectomía en pacientes que han recibido quimioterapia neoadyuvante (QTNA) sigue siendo controvertida. El objetivo de este estudio es analizar y comparar resultados oncológicos y las tasas de complicaciones y reintervención en pacientes sometidas a QTNA y un grupo control.MétodosAnálisis observacional retrospectivo de casos-controles. Pacientes con cáncer de mama inter...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 9 December 2019Source: Cirugía Española (English Edition)Author(s): Jaime Ruiz-Tovar, Raquel Sanchez-Santos, Ester Martín-García-Almenta, Esther García Villabona, Artur Marc Hernandez, Alberto Hernández-Matías, José Manuel Ramírez, Grupo de Trabajo de Cirugía Bariátrica del Grupo Español de Rehabilitación Multimodal (GERM)AbstractEnhanced recovery after surgery (ERAS) protocols are care programs based on scientific evidence and focused on postoperative recovery. They encompass all aspects of patient...
Source: Cirugia Espanola - Category: Surgery Source Type: research
In conclusion, LINC01518 knockdown inhibited tumorigenicity in ESCC cells by suppression of PIK3CA/Akt pathway through upregulating miR-1-3p. PMID: 31810385 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
In this study, we aimed to investigate the potential mechanism of PRSS3 dysregulation in PC. In this research, low miR-217 and high circ-ADAM9 expression were found in PC tissues and cell lines, which was closely associated with advanced clinical stage and lymph node metastasis. Patients with low miR-217 or high circ-ADAM9 expression had shorter survival time than those with high miR-217 or low circ-ADAM9 expression. Functionally, manipulation of miR-217 and circ-ADAM9 expression showed opposite effects on cell proliferation, migration and invasion. Stepwise mechanism studies indicated that circ-ADAM9 alleviated the inhibi...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
ConclusionsThe association between the WIC food package change and obesity varied by type of infant food package received, with the strongest associations observed for those who were mostly breastfed.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
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