Consumer Health: What do you know about these 3 rare childhood cancers?
Childhood cancer rates have been rising slightly for the past few decades, and about 10,470 children in the U.S. under the age of 15 will be diagnosed with cancer in 2022, according to the American Cancer Society. September is Childhood Cancer Awareness Month, which makes this a good time to learn about three rare types of cancers in children: retinoblastoma, rhabdomyosarcoma and Wilms' tumor. Retinoblastoma Retinoblastoma is a rare form of eye cancer that begins in the… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - September 26, 2022 Category: Databases & Libraries Source Type: news

New NCCN guidelines analyze evidence for cancer type found almost exclusively in children
(National Comprehensive Cancer Network) National Comprehensive Cancer Network publishes first-ever complete medical guidelines for a pediatric solid tumor, so children everywhere receive the best care based on the latest research. NCCN Guidelines for Wilms Tumor shares information for earlier, safer diagnosis and treatment in effort to reduce disparities; doctors warn of late diagnosis as a possible impact from the COVID-19 pandemic. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 17, 2021 Category: International Medicine & Public Health Source Type: news

What Is Wilms Tumor?
Title: What Is Wilms Tumor?Category: Diseases and ConditionsCreated: 12/18/2020 12:00:00 AMLast Editorial Review: 12/18/2020 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - December 18, 2020 Category: Cancer & Oncology Source Type: news

Root of childhood kidney cancer discovered
(Wellcome Trust Sanger Institute) A fundamental change in our understanding of the childhood kidney cancer Wilms' tumor is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators. By comparing genome sequences from normal kidney tissue and tumors, the team identified patches of normal-looking kidney tissue that in fact carried DNA changes that cause Wilms' tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 5, 2019 Category: Cancer & Oncology Source Type: news

Embryonal precursors of Wilms tumor
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissues that preceded tumor development. These clonal expansions were defined by somatic mutations shared between tumor and normal tissues but absent from blood cells. We also found hyper...
Source: ScienceNOW - December 4, 2019 Category: Science Authors: Coorens, T. H. H., Treger, T. D., Al-Saadi, R., Moore, L., Tran, M. G. B., Mitchell, T. J., Tugnait, S., Thevanesan, C., Young, M. D., Oliver, T. R. W., Oostveen, M., Collord, G., Tarpey, P. S., Cagan, A., Hooks, Y., Brougham, M., Reynolds, B. C., Barone, Tags: Development, Medicine, Diseases reports Source Type: news

New Study Uncovers Underlying Mechanisms in Wilms Tumor
A study shows that microRNA depressesPLAG1, causing tumor growth in Wilms tumors. (Source: CancerNetwork)
Source: CancerNetwork - August 24, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor compos...
Source: ScienceNOW - August 9, 2018 Category: Science Authors: Young, M. D., Mitchell, T. J., Vieira Braga, F. A., Tran, M. G. B., Stewart, B. J., Ferdinand, J. R., Collord, G., Botting, R. A., Popescu, D.-M., Loudon, K. W., Vento-Tormo, R., Stephenson, E., Cagan, A., Farndon, S. J., Del Castillo Velasco-Herrera, M., Tags: Development, Medicine, Diseases reports Source Type: news

Scientists Identify New Mechanisms Underlying Pediatric Kidney Cancer
In a new study, researchers have found that miRNA processing mutations exhibit higher levels of Pleomorphic adenoma gene 1 (PLAG1), a protein that normally functions during development to turn on IGF2 expression. In kidney cells with miRNA mutations, PLAG1 levels are abnormally high, leading to inappropriate production of IGF2, which in turn promotes Wilms tumor formation.08/02/2018 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - August 2, 2018 Category: Urology & Nephrology Source Type: news

'We ’ll never be normal again:’ Little boy who’s been through a lot serves as honorary survivor at Relay for Life
A kindergartner from Wisconsin who was diagnosed with Wilms tumor serves as honorary survivor at Relay for Life.07/30/2018 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - July 30, 2018 Category: Urology & Nephrology Source Type: news

Study shows a new approach to treating patients with stage IV Wilms tumor
(Children's National Health System) A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 25, 2018 Category: Cancer & Oncology Source Type: news

SELLAS Life Sciences Announces Appointment of Gene Mack as Chief Financial Officer and Treasurer
NEW YORK, April 20, 2018 -- (Healthcare Sales & Marketing Network) -- SELLAS Life Sciences Group Inc., (Nasdaq:SLS) (SELLAS), a clinical-stage biopharmaceutical company focused on novel cancer immunotherapies for a broad range of cancer indications, today ... Biopharmaceuticals, Oncology, Personnel SELLAS Life Sciences, galinpepimut-S, Wilms Tumor 1 (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 20, 2018 Category: Pharmaceuticals Source Type: news

Should I Worry About This Telangiectasia?
Discussion Vascular stains are common problems that parents seek guidance about as they are often particularly worried that there may be an underlying problem or that it may be a long-term cosmetic problem. Fortunately many resolve or become less prominent or have treatment available. The term vascular stains includes all vascular malformations but commonly refers more directly to capillary malformations which are quite common. Some common vascular stains include: Nevus simplex Names: Angel’s kiss (glabella or forehead), salmon patch, stork bite (nape of neck), nevus roseus, fading macular stain Epidemiology: Very ...
Source: - January 29, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Prognostic Indicators Further Defined in Pediatric Wilms Tumor Prognostic Indicators Further Defined in Pediatric Wilms Tumor
Combined lymph node and loss of heterozygosity (LOH) status are highly predictive of event-free survival (EFS) in certain young patients with Wilms tumor (WT), according to researchers in the U.S. and Canada.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 27, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Comprehensive genomic analysis offers insights into causes of Wilms tumor development
(Ann& Robert H. Lurie Children's Hospital of Chicago) Mutations involving a large number of genes converge on two pathways during early kidney development that lead to Wilms tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 21, 2017 Category: Cancer & Oncology Source Type: news

GPS Immunization for Multiple Myeloma Is Well Tolerated
Among high-risk multiple myeloma patients, post-ASCT immunization with the Wilms tumor 1 peptide mixture galinpepimut-S is well tolerated and is associated with promising progression-free survival. (Source: CancerNetwork)
Source: CancerNetwork - June 8, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Conferences/ASCO Multiple Myeloma News Source Type: news