MR-HIFU and ThermoDox to Treat Recurrent Childhood Tumors: Interview with AeRang Kim, Principal Investigator
Children’s National Health System and the Celsion Corporation (Lawrenceville, NJ) have recently announced a Phase I clinical trial in the US to determine a safe and tolerable dose of ThermoDox in conjunction with non-invasive magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU). The trial is aimed on young adults and children with recurring solid tumors.
ThermoDox technology consists of liposomes loaded with doxorubicin, a conventional chemotherapeutic drug. Liposomes are small lipid structures which can be used to encapsulate and deliver drugs through the bloodstream. While liposomal doxorubicin formu...
Source: Medgadget - December 6, 2016 Category: Medical Equipment Authors: Conn Hastings Tags: Exclusive Nanomedicine Oncology Source Type: blogs
Aneuploidy and Carcinogenesis
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. The book has an extensive glossary, that explains the meaning and relevance of medical terms appearing throughout the chapters. The glossary can be read as a stand-along document. Here is an example of one term, "aneuploidy", excerpted from the glossary.Aneuploidy - The presence of an abnormal number of chromosomes (for the species) in a cell...
Source: Specified Life - July 15, 2014 Category: Pathologists Tags: aneuploidy cancer types carcinogenesis common cancers common disease cytogenetics glossary orphan disease orphan drugs rare cancers rare disease tumor biology tumor types types of cancer Source Type: blogs
Rare Cancer are Subsets of Common Cancers
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. One of the key ideas developed in the book is that each common diseases is actually an aggregate of cellular processes that are present, individually, in rare diseases. In the case of the common cancers, we can find specific rare diseases that are subsets of the common diseases. Here is an excerpt from Chapter 8: 8.3.3 Inherited syndromes that...
Source: Specified Life - July 9, 2014 Category: Pathologists Tags: cancer syndromes carcinogenesis common cancers common disease familial cancer syndromes genetic disease orphan disease orphan drugs rare cancers rare disease Source Type: blogs
Infusing Large Numbers of Immune Cells as a Therapy
Since it is possible to take a patient's cells and generate a very large number of immune cells, far more than the patient would ever have normally, and since it's possible to make some alterations to immune cells to make them more effective, why not do this? It's probably the case that even generally healthy older people would benefit from a regular infusion of large numbers of their own immune cells, or even donor cells, given the way in which the immune system declines with age, but under present medical regulation you'll only ever see it deployed as a treatment for late stage disease:
[Researchers] have successfully i...
Source: Fight Aging! - February 28, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Daily News Source Type: blogs
