DROSHA regulates mesenchymal gene expression in Wilms tumor
This study reveals genotype-transcriptome relationships in Wilms tumor and points to ferroptosis as a potentially therapeutic vulnerability in one subset of Wilms tumor.PMID:38647377 | DOI:10.1158/1541-7786.MCR-23-0930 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Patricia D B Tiburcio Kavita Desai Jiwoong Kim Qinbo Zhou Lei Guo Xue Xiao Li Zhou Aysen Yuksel Daniel R Catchpoole James F Amatruda Lin Xu Kenneth S Chen Source Type: research
Cancers, Vol. 16, Pages 1567: Discovery of Novel Potential Prognostic Markers and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced-Stage Wilms Tumor
In this study, we aimed to discover potential mutation markers and drug targets associated with chemotherapy resistance in advanced-stage WT. We performed exome sequencing to detect somatic mutations and molecular targets in 43 WT samples, comprising 26 advanced-stage WTs, of which 7 cases were chemotherapy-resistant. Our analysis revealed four genes (ALPK2, C16orf96, PRKDC, and SVIL) that correlated with chemotherapy resistance and reduced disease-free survival in advanced-stage WT. Additionally, we identified driver mutations in 55 genes within the chemotherapy-resistant group, including 14 druggable cancer driver genes....
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Pongsakorn Choochuen Natakorn Nokchan Natthapon Khongcharoen Wison Laochareonsuk Komwit Surachat Thirachit Chotsampancharoen Thanit Sila Sangkhathat Tags: Article Source Type: research
Hemangioblastoma: An Uncommon Cause of Polycythemia in a Child
We report a 13-year-old girl with primarily neurological symptoms identified to be polycythemic during routine evaluation. Clinical examination and neuroimaging subsequently confirmed an intracranial space occupying lesion which was excised. Hemoglobin level normalized after tumor excision. This case report emphasizes the need for thorough systemic evaluation including central nervous system examination in children identified to be polycythemic. Keywords: CNS tumor; hemangioblastoma; polycythemia.PMID:38615229 | DOI:10.33314/jnhrc.v21i3.4160 (Source: Cell Research)
Source: Cell Research - April 14, 2024 Category: Cytology Authors: Surabhi Aryal Arun Kumar Sharma Source Type: research
GSE239469 Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling [RNA-seq]
Contributors : Liling Wan ; Yiman Liu ; Qinglan LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGain-of-function mutations in the chromatin ‘reader’ ENL, identified in AML and Wilms tumor, have been shown to induce aberrant formation of transcriptional condensates in cellular systems. However, the precise role of these mutations and their condensate forming property in tumorigenesis remains unclear. By creating a conditional knock-i n mouse model for the most prevalent ENL mutation, we establish ENL mutant as a bona fide oncogenic driver of acute myeloid leukemia in vivo. Het...
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE239468 Condensate-promoting ENL mutation induces tumorigenesis via chromatin remodeling [ChIP-seq and CUT & Tag]
Contributors : Liling Wan ; Yiman Liu ; Qinglan LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusGain-of-function mutations in the chromatin ‘reader’ ENL, identified in AML and Wilms tumor, have been shown to induce aberrant formation of transcriptional condensates in cellular systems. However, the precise role of these mutations and their condensate forming property in tumorigenesis remains unclear. By creating a conditional knock-i n mouse model for the most prevalent ENL mutation, we establish ENL mutant as a bona fide oncogenic driver of acute myeloid leukemi...
Source: GEO: Gene Expression Omnibus - April 14, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study
ConclusionThis retrospective international collaborative study showed classic type congenital mesoblastic nephroma predominantly presented as a homogeneous T2-weighted isointense mass with a typical concentric ring sign, whereas the cellular type appeared more heterogeneous. Future studies may use identified MRI characteristic of congenital mesoblastic nephroma for validation and for exploring the discriminative non-invasive value of MRI, especially from Wilms tumor.Graphical Abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 13, 2024 Category: Radiology Source Type: research
Efficacy Of Neoadjuvant Chemotherapy On Nephron-Sparing Surgery For Wilms Tumor In Horseshoe Kidney
The recent call for the development of standardized criteria to guide the feasibility of nephron-sparing surgery (NSS) for Wilms tumor (WT) in horseshoe kidney [1] stimulated us to share our thoughts on the subject. Amongst the proposed criteria, the authors appropriately included>50% preservation of the remaining renal parenchyma. This is actually the minimum requirement to be met in NSS for horseshoe kidney, given that the removal of one-half along with half a portion of the connecting isthmus equals unilateral nephrectomy in the normal (two-kidney) population. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - April 12, 2024 Category: Surgery Authors: Denis A. Cozzi, Silvia Ceccanti Source Type: research
Nephroblastoma-specific dysregulated gene SNHG15 with prognostic significance: scRNA-Seq with bulk RNA-Seq data and experimental validation
Discov Oncol. 2024 Mar 25;15(1):87. doi: 10.1007/s12672-024-00946-w.ABSTRACTWilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing (scRNA-Seq) and Bulk RNA sequencing (RNA-Seq) analysis of heterogeneity between different cell types in pediatric WT tissues could more accurately find prognostic markers, but this is lacking. RNA-Seq and clinical data related to WT were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Small nucleolar RNA host gene 15 (SNHG15) was identified as a r...
Source: Cancer Control - March 25, 2024 Category: Cancer & Oncology Authors: Mengmeng Chang Ding Li Li Su Chen Ding Zhiyi Lu Hongjie Gao Fengyin Sun Source Type: research
Nomogram for personalized prognostic assessment of children with favorable histology Wilms tumor: A retrospective analysis
CONCLUSION: This study provides valuable insights into the clinical characteristics and outcomes of FHWT patients. Accurate staging and histological risk assessment are important in predicting outcomes, and the prognostic nomogram we developed can be a useful tool for clinicians to assess patient prognosis and make informed treatment decisions.PMID:38522976 | DOI:10.1016/j.urolonc.2023.12.009 (Source: Urologic Oncology)
Source: Urologic Oncology - March 24, 2024 Category: Urology & Nephrology Authors: Zihong Wang Jiayi Li Pei Liu Xianghui Xie Hongcheng Song Weiping Zhang Source Type: research
Nomogram for personalized prognostic assessment of children with favorable histology Wilms tumor: A retrospective analysis
CONCLUSION: This study provides valuable insights into the clinical characteristics and outcomes of FHWT patients. Accurate staging and histological risk assessment are important in predicting outcomes, and the prognostic nomogram we developed can be a useful tool for clinicians to assess patient prognosis and make informed treatment decisions.PMID:38522976 | DOI:10.1016/j.urolonc.2023.12.009 (Source: Urologic Oncology)
Source: Urologic Oncology - March 24, 2024 Category: Urology & Nephrology Authors: Zihong Wang Jiayi Li Pei Liu Xianghui Xie Hongcheng Song Weiping Zhang Source Type: research
Nomogram for personalized prognostic assessment of children with favorable histology Wilms tumor: A retrospective analysis
CONCLUSION: This study provides valuable insights into the clinical characteristics and outcomes of FHWT patients. Accurate staging and histological risk assessment are important in predicting outcomes, and the prognostic nomogram we developed can be a useful tool for clinicians to assess patient prognosis and make informed treatment decisions.PMID:38522976 | DOI:10.1016/j.urolonc.2023.12.009 (Source: Urologic Oncology)
Source: Urologic Oncology - March 24, 2024 Category: Urology & Nephrology Authors: Zihong Wang Jiayi Li Pei Liu Xianghui Xie Hongcheng Song Weiping Zhang Source Type: research
