MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1
CONCLUSION: miR-193a could inhibit early retinal neuronal cell apoptosis in DM rats by targeting and negatively regulating WT1 expression.PMID:38182143 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - January 5, 2024 Category: Laboratory Medicine Authors: Juan Yu Kehai Che Chong Gao Xuemei Pu Lijun Ren Source Type: research
MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1
CONCLUSION: miR-193a could inhibit early retinal neuronal cell apoptosis in DM rats by targeting and negatively regulating WT1 expression.PMID:38182143 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - January 5, 2024 Category: Laboratory Medicine Authors: Juan Yu Kehai Che Chong Gao Xuemei Pu Lijun Ren Source Type: research
MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1
CONCLUSION: miR-193a could inhibit early retinal neuronal cell apoptosis in DM rats by targeting and negatively regulating WT1 expression.PMID:38182143 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - January 5, 2024 Category: Laboratory Medicine Authors: Juan Yu Kehai Che Chong Gao Xuemei Pu Lijun Ren Source Type: research
MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1
CONCLUSION: miR-193a could inhibit early retinal neuronal cell apoptosis in DM rats by targeting and negatively regulating WT1 expression.PMID:38182143 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - January 5, 2024 Category: Laboratory Medicine Authors: Juan Yu Kehai Che Chong Gao Xuemei Pu Lijun Ren Source Type: research
MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1
CONCLUSION: miR-193a could inhibit early retinal neuronal cell apoptosis in DM rats by targeting and negatively regulating WT1 expression.PMID:38182143 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - January 5, 2024 Category: Laboratory Medicine Authors: Juan Yu Kehai Che Chong Gao Xuemei Pu Lijun Ren Source Type: research
CT radiomics to differentiate between Wilms tumor and clear cell sarcoma of the kidney in children
To investigate the role of CT radiomics in distinguishing Wilms tumor (WT) from clear cell sarcoma of the kidney (CCSK) in pediatric patients. (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - January 5, 2024 Category: Radiology Authors: Yaxin Deng, Haoru Wang and Ling He Tags: Research Source Type: research
WTAP-mediated m < sup > 6 < /sup > A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis
This study aimed to investigate the role of m6A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes. Mechanistically, the m6A modification and relative downstream targets in osteoarthritic cartilage were assessed by methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing, which indicated that the expression of frizzled-related protein (F...
Source: Molecular Medicine - January 3, 2024 Category: Molecular Biology Authors: Xueying An Rongliang Wang Zhongyang Lv Wenshu Wu Ziying Sun Rui Wu Wenjin Yan Qing Jiang Xingquan Xu Source Type: research
Network pharmacology and molecular docking of endogenous active metabolites in diabetic kidney disease
CONCLUSIONS: This study demonstrated the significance of the 2-HPG/SYNJ1 signaling axis in safeguarding the foot process of podocytes in DKD.PMID:38152048 | DOI:10.1080/0886022X.2023.2290927 (Source: Renal Failure)
Source: Renal Failure - December 28, 2023 Category: Urology & Nephrology Authors: Xinmiao Xie Yanzhe Wang Sijia Chen Yuyuan Liu Fengqin Li Chuchu Zeng Ling Zhang Xiaoxia Wang Source Type: research
Network pharmacology and molecular docking of endogenous active metabolites in diabetic kidney disease
CONCLUSIONS: This study demonstrated the significance of the 2-HPG/SYNJ1 signaling axis in safeguarding the foot process of podocytes in DKD.PMID:38152048 | PMC:PMC10763839 | DOI:10.1080/0886022X.2023.2290927 (Source: Renal Failure)
Source: Renal Failure - December 28, 2023 Category: Urology & Nephrology Authors: Xinmiao Xie Yanzhe Wang Sijia Chen Yuyuan Liu Fengqin Li Chuchu Zeng Ling Zhang Xiaoxia Wang Source Type: research
Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor: a systematic review and meta-analysis
AbstractTo evaluate the efficiency and long-term renal function of nephron sparing surgery (NSS) in unilateral WT patients compared with radical nephrectomy (RN). The review was performed following Cochrane Handbook guidelines and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched five databases (Pubmed, Embase, Scopus, Web of Science and Cochrane) for studies reporting the efficiency and late renal function of NSS and/or RN on February 10, 2023. Comparative studies were evaluated by Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) and RoB 2.0. Assessed outcomes inclu...
Source: Pediatric Surgery International - December 27, 2023 Category: Surgery Source Type: research
Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
CONCLUSION: While WT predisposition in BWS is well-established, as are 11p15 alterations in nonBWS-WT, this study focused on stratifying tumor genomics by 11p15 status. Further investigation of our findings may identify novel therapeutic targets in WT oncogenesis.PMID:38142265 | DOI:10.1038/s41416-023-02538-x (Source: Cancer Control)
Source: Cancer Control - December 23, 2023 Category: Cancer & Oncology Authors: Snehal Nirgude Natali S Sobel Naveh Sanam L Kavari Emily M Traxler Jennifer M Kalish Source Type: research
