Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
CONCLUSION: While WT predisposition in BWS is well-established, as are 11p15 alterations in nonBWS-WT, this study focused on stratifying tumor genomics by 11p15 status. Further investigation of our findings may identify novel therapeutic targets in WT oncogenesis.PMID:38142265 | DOI:10.1038/s41416-023-02538-x (Source: Cancer Control)
Source: Cancer Control - December 23, 2023 Category: Cancer & Oncology Authors: Snehal Nirgude Natali S Sobel Naveh Sanam L Kavari Emily M Traxler Jennifer M Kalish Source Type: research
Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
British Journal of Cancer, Published online: 23 December 2023; doi:10.1038/s41416-023-02538-xCancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development (Source: British Journal of Cancer)
Source: British Journal of Cancer - December 23, 2023 Category: Cancer & Oncology Authors: Snehal Nirgude Natali S. Sobel Naveh Sanam L. Kavari Emily M. Traxler Jennifer M. Kalish Source Type: research
Severe hepatic sinusoidal obstruction syndrome in a patient with Wilms tumor and hereditary spherocytosis
AbstractA 7-year-old girl with a history of splenectomy for hereditary spherocytosis (HS) was diagnosed with renal hematoma after a blunt abdominal trauma while receiving aspirin. Multiple erythrocyte transfusions and transarterial embolization were performed without success. Eventual nephrectomy revealed severely necrotic and perforated Stage III Wilms tumor (WT). Radiochemotherapy was administered, but by the eighth week, she developed severe hepatic sinusoidal obstruction syndrome (HSOS). Her ferritin level at the time was 3406 ng/ml. Defibrotide and aggressive supportive measures provided full recovery. The patient w...
Source: International Cancer Conference Journal - December 21, 2023 Category: Cancer & Oncology Source Type: research
BRAF Exon 15 Mutations in the Evaluation of Well-Differentiated Epithelial Nephroblastic Neoplasms in Children: A Report From the Children's Oncology Group Study AREN03B2
CONCLUSIONS.—: Pediatric epithelial neoplasms with features of MA that show partial encapsulation and/or modest mitotic activity may be classified as MAs. Although BRAF mutation supports the diagnosis of MA, it is not required for the diagnosis.PMID:38116848 | DOI:10.5858/arpa.2022-0528-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - December 20, 2023 Category: Laboratory Medicine Authors: Jeffery A Goldstein Lindsay A Renfro Lawrence J Jennings Elizabeth A Mullen James Geller Kelly Vallance Conrad V Fernandez Elizabeth J Perlman Source Type: research
BRAF Exon 15 Mutations in the Evaluation of Well-Differentiated Epithelial Nephroblastic Neoplasms in Children: A Report From the Children's Oncology Group Study AREN03B2
CONCLUSIONS.—: Pediatric epithelial neoplasms with features of MA that show partial encapsulation and/or modest mitotic activity may be classified as MAs. Although BRAF mutation supports the diagnosis of MA, it is not required for the diagnosis.PMID:38116848 | DOI:10.5858/arpa.2022-0528-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - December 20, 2023 Category: Laboratory Medicine Authors: Jeffery A Goldstein Lindsay A Renfro Lawrence J Jennings Elizabeth A Mullen James Geller Kelly Vallance Conrad V Fernandez Elizabeth J Perlman Source Type: research
Cancers, Vol. 16, Pages 43: Congenital Tumors & mdash;Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers, Vol. 16, Pages 43: Congenital Tumors—Magnetic Resonance Imaging Findings with Focus on Rare Tumors
Cancers doi: 10.3390/cancers16010043
Authors:
Kwasniewicz
Wieczorek-Pastusiak
Romaniuk-Doroszewska
Bekiesinska-Figatowska
Congenital tumors are rare and, owing to this rarity, there is limited information on many of them. A total of 839 fetal and postnatal MRI studies performed in the first 3 months of life were retrospectively reviewed. They were performed with the use of 1.5 T scanners. Seventy-six tumors were diagnosed based on fetal MRI between 20 and 37 gestational weeks, and 27 were ...
Source: Cancers - December 20, 2023 Category: Cancer & Oncology Authors: Kwasniewicz Wieczorek-Pastusiak Romaniuk-Doroszewska Bekiesinska-Figatowska Tags: Article Source Type: research
Characteristics and clinical outcomes of children with Wilms ’ tumour: A 15-year experience in a single centre in Nigeria
Wilms' tumor (WT) is the most common paediatric renal tumor and is one of the most treatment-responsive solid tumours. Survival from Wilms tumour (WT) in sub-Saharan Africa remains dismal as a result of late presentation, treatment abandonment and infrastructure deficit. The purpose of this study was to analyze the clinical outcome of children with Wilms tumour managed in a Nigerian referral centre over a 15-year period. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - December 15, 2023 Category: Surgery Authors: Abdulrasheed A. Nasir, Nurudeen T. Abdur-Raheem, Lukman O. Abdur-Rahman, Taibat T. Ibiyeye, Tolulope O. Sayomi, Olanrewaju T. Adedoyin, James O. Adeniran Source Type: research
Emerging functions and significance of circCDYL in human disorders
Mol Biol Rep. 2023 Dec 12;51(1):7. doi: 10.1007/s11033-023-08993-2.ABSTRACTCircular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple m...
Source: Molecular Biology Reports - December 12, 2023 Category: Molecular Biology Authors: Sheyda Khalilian Mohammad Amin Khazeei Tabari Mohammad Amin Omrani Soudeh Ghafouri-Fard Source Type: research
Emerging functions and significance of circCDYL in human disorders
Mol Biol Rep. 2023 Dec 12;51(1):7. doi: 10.1007/s11033-023-08993-2.ABSTRACTCircular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple m...
Source: Mol Biol Cell - December 12, 2023 Category: Molecular Biology Authors: Sheyda Khalilian Mohammad Amin Khazeei Tabari Mohammad Amin Omrani Soudeh Ghafouri-Fard Source Type: research
Emerging functions and significance of circCDYL in human disorders
Mol Biol Rep. 2023 Dec 12;51(1):7. doi: 10.1007/s11033-023-08993-2.ABSTRACTCircular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple m...
Source: Molecular Biology Reports - December 12, 2023 Category: Molecular Biology Authors: Sheyda Khalilian Mohammad Amin Khazeei Tabari Mohammad Amin Omrani Soudeh Ghafouri-Fard Source Type: research
Emerging functions and significance of circCDYL in human disorders
Mol Biol Rep. 2023 Dec 12;51(1):7. doi: 10.1007/s11033-023-08993-2.ABSTRACTCircular RNAs (circRNAs) are a group of non-coding transcripts in which a loop structure is shaped via a back splicing procedure. They have central roles in the regulation of gene expression. hsa_circ_0008285, alternatively named as circCDYL, is a circular RNA originated from the exon 4 of CDYL gene. It is produced by a back-splice incident and is mainly located in the cytoplasm. It has no internal ribosome entry site, open reading frame and intronic sequences. CircCDYL dysregulation has been reported in the malignant conditions including multiple m...
Source: Mol Biol Cell - December 12, 2023 Category: Molecular Biology Authors: Sheyda Khalilian Mohammad Amin Khazeei Tabari Mohammad Amin Omrani Soudeh Ghafouri-Fard Source Type: research
Ossifying renal tumor of infancy: a case report
We reported a case of a 21-day-old patient diagnosed with ORTI who underwent partial nephrectomy and had good follow-up. The unique features of this case are the strong expression of Wilms Tumor-1 (WT-1) and a high Ki-67 index in the hot spot area. ORTI is considered to have a favorable prognosis. Due to the rarity of WT-1 positivity and high Ki-67 index, we should be highly aware that this patient needs to be followed closely. In addition, we reviewed the available literature on ORTI, with the aim of summarizing the diagnostic and therapeutic experience. The diagnosis needs to be given cautiously on the basis of clinical ...
Source: Frontiers in Oncology - December 12, 2023 Category: Cancer & Oncology Source Type: research
A Surprise During “Routine” Orchidopexy: An Extra-renal Wilms Tumor Case Report
We present the case of a 12-month-old male diagnosed with an extra-renal Wilms tumor (ERWT) found incidentally at the time of inguinal orchiopexy. He was staged and treated according to Children ’s Oncology Group (COG) protocol, with no evidence for disease at the end of treatment. We review the patient’s presentation and treatment course, followed by a review of current literature on ERWT and considerations for management. (Source: Urology)
Source: Urology - December 3, 2023 Category: Urology & Nephrology Authors: Hailey Silverii, Nya Nelson, Kathleen Kieran, Mark Cain Source Type: research
A Surprise During “Routine” Orchidopexy: An Extrarenal Wilms Tumor Case Report
We present the case of a 12-month-old male diagnosed with an extrarenal Wilms tumor found incidentally at the time of inguinal orchiopexy. He was staged and treated according to Children ’s Oncology Group (COG) protocol, with no evidence for disease at the end of treatment. We review the patient’s presentation and treatment course, followed by a review of current literature on extrarenal Wilms tumor and considerations for management. (Source: Urology)
Source: Urology - December 3, 2023 Category: Urology & Nephrology Authors: Hailey Silverii, Nya Nelson, Kathleen Kieran, Mark Cain Tags: Pediatric Case Reports Source Type: research
WTAP-Mediated N6-Methyladenosine of RNAs Facilitate the Pathophysiology of Atopic Dermatitis
N6-methyladenosine (m6A) is the most abundant dynamic and reversible internal chemical modification of RNA in eukaryotic cells and is essential in multiple pathophysiological processes. However, it has not been reported in atopic dermatitis (AD). We used Arraystar m6A-mRNA epitranscriptomic microarray to screen for differentially expressed genes (DEGs) and their m6A levels, and m6A-related enzymes in patients with AD. We confirmed that the m6A RNA methyltransferase Wilms tumor 1-associated protein (WTAP) and two candidate DEGs (S100 calcium-binding protein A9 [S100A9] and serpin peptidase inhibitor, clade B (ovalbumin), me...
Source: Journal of Investigative Dermatology - November 27, 2023 Category: Dermatology Authors: Lina Tan, Xue Chen, Siyu Yan, Aiyuan Guo, Lihua Gao, Lu Zhou, Yanping Zhou, Jinrong Zeng, Jianyun Lu Tags: Original Article Source Type: research
