Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies
Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2305322120. doi: 10.1073/pnas.2305322120. Epub 2023 Aug 21.ABSTRACTT cell bispecific antibodies (TCBs) are the focus of intense development for cancer immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs have emerged as a new class of biotherapeutics with improved specificity. These TCBs simultaneously bind to target peptides presented by the polymorphic, species-specific MHC encoded by the human leukocyte antigen (HLA) allele present on target cells and to the CD3 coreceptor expressed by human T lymphocytes. Unfortunately, traditional models f...
Source: Cancer Control - August 21, 2023 Category: Cancer & Oncology Authors: Katharina T Kroll Mariana M Mata Kimberly A Homan Virginie Micallef Alejandro Carpy Ken Hiratsuka Ryuji Morizane Annie Moisan Marcel Gubler Antje-Christine Walz Estelle Marrer-Berger Jennifer A Lewis Source Type: research
RNA N6 ‑methyladenosine methyltransferase WTAP promotes the differentiation of endothelial progenitor cells
In conclusion, the present study highlighted the involvement of m6A in regulating EPC differentiation, with WTAP acting as a promoter of EPC differentiation.PMID:37602313 | PMC:PMC10433437 | DOI:10.3892/etm.2023.12119 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 21, 2023 Category: General Medicine Authors: Longyun Wu Lili Niu Zhou Yang Qiaoyun Xia Jingyuan Xu Xiaolan Lu Source Type: research
High cholesterol diet-induced testicular dysfunction in rats
CONCLUSIONS: Our results showed that a high-cholesterol diet adversely affected testosterone production and sperm progressive motility, possibly due to Leydig, Sertoli, and germ cell abnormalities.PMID:37596375 | DOI:10.1007/s42000-023-00472-4 (Source: Hormones)
Source: Hormones - August 18, 2023 Category: Endocrinology Authors: Luna Liu Meijie Zhang Fangjie Jiang Dandan Luo Shuang Liu Yu Su Qingbo Guan Chunxiao Yu Source Type: research
CCNB1 is a novel prognostic biomarker and promotes proliferation, migration and invasion in Wilms tumor
Wilms tumour (WT) is a mixed type of embryonal tumour that usually occurs in early childhood. However, our knowledge of the pathogenesis or progression mechanism of WT is inadequate, and there is a scarcity of... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - August 17, 2023 Category: Genetics & Stem Cells Authors: Bin Xiang, Mei-Lin Chen, Zhi-Qiang Gao, Tao Mi, Qin-Lin Shi, Jun-Jun Dong, Xiao-Mao Tian, Feng Liu and Guang-Hui Wei Tags: Research Source Type: research
Low risk of embryonic and other cancers in PIK3CA-related overgrowth spectrum: Impact on screening recommendations
Clin Genet. 2023 Aug 14. doi: 10.1111/cge.14410. Online ahead of print.ABSTRACTThe PIK3CA-related overgrowth spectrum (PROS) encompasses various conditions caused by mosaic activating PIK3CA variants. PIK3CA somatic variants are also involved in various cancer types. Some generalized overgrowth syndromes are associated with an increased risk of Wilms tumor (WT). In PROS, abdominal ultrasound surveillance has been advocated to detect WT. We aimed to determine the risk of embryonic and other types of tumors in patients with PROS in order to evaluate surveillance relevance. We searched the clinical charts from 267 PROS patien...
Source: Clinical Genetics - August 14, 2023 Category: Genetics & Stem Cells Authors: Laurence Faivre Jean-Charles Cr épin Manon R éda Sophie Nambot Virginie Carmignac Caroline Abadie Tristan Mirault C écile Faure-Conter Juliette Mazereeuw-Hautier Aude Maza Eve Puzenat Marie-Agn ès Collonge-Rame Anne-Claire Bursztejn Christophe Philipp Source Type: research
Low risk of embryonic and other cancers in PIK3CA-related overgrowth spectrum: Impact on screening recommendations
Clin Genet. 2023 Aug 14. doi: 10.1111/cge.14410. Online ahead of print.ABSTRACTThe PIK3CA-related overgrowth spectrum (PROS) encompasses various conditions caused by mosaic activating PIK3CA variants. PIK3CA somatic variants are also involved in various cancer types. Some generalized overgrowth syndromes are associated with an increased risk of Wilms tumor (WT). In PROS, abdominal ultrasound surveillance has been advocated to detect WT. We aimed to determine the risk of embryonic and other types of tumors in patients with PROS in order to evaluate surveillance relevance. We searched the clinical charts from 267 PROS patien...
Source: Clinical Genetics - August 14, 2023 Category: Genetics & Stem Cells Authors: Laurence Faivre Jean-Charles Cr épin Manon R éda Sophie Nambot Virginie Carmignac Caroline Abadie Tristan Mirault C écile Faure-Conter Juliette Mazereeuw-Hautier Aude Maza Eve Puzenat Marie-Agn ès Collonge-Rame Anne-Claire Bursztejn Christophe Philipp Source Type: research
Low risk of embryonic and other cancers in PIK3CA-related overgrowth spectrum: Impact on screening recommendations
Clin Genet. 2023 Aug 14. doi: 10.1111/cge.14410. Online ahead of print.ABSTRACTThe PIK3CA-related overgrowth spectrum (PROS) encompasses various conditions caused by mosaic activating PIK3CA variants. PIK3CA somatic variants are also involved in various cancer types. Some generalized overgrowth syndromes are associated with an increased risk of Wilms tumor (WT). In PROS, abdominal ultrasound surveillance has been advocated to detect WT. We aimed to determine the risk of embryonic and other types of tumors in patients with PROS in order to evaluate surveillance relevance. We searched the clinical charts from 267 PROS patien...
Source: Clinical Genetics - August 14, 2023 Category: Genetics & Stem Cells Authors: Laurence Faivre Jean-Charles Cr épin Manon R éda Sophie Nambot Virginie Carmignac Caroline Abadie Tristan Mirault C écile Faure-Conter Juliette Mazereeuw-Hautier Aude Maza Eve Puzenat Marie-Agn ès Collonge-Rame Anne-Claire Bursztejn Christophe Philipp Source Type: research
Prophylactic bilateral nephrectomy and preemptive kidney transplantation for Denys –Drash syndrome prior to development of kidney failure
ConclusionWe performed prophylactic bilateral nephrectomy with KTX on a DDS patient who had not developed kidney failure or Wilms tumor by the age of 7 years. Although the risk of development of Wilms tumor in such a patient is unclear, this treatment may be an optimal approach for patients who are physically able to undergo KTX, considering the potentially lethal nature of Wilms tumor in CKD patients. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - August 12, 2023 Category: Urology & Nephrology Source Type: research
N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression
The study was design to investigate the functional roles of Wilms tumor 1-associated protein (WTAP), an enzyme catalyzes m6A modification, in the pathogenesis of osteoarthritis (OA) and further elucidate its p... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - August 10, 2023 Category: Molecular Biology Authors: Zhaowei Lin, Tao Jiang, Wei Zheng, Jiayuan Zhang, Anan Li, Chao Lu and Wengang Liu Tags: Research Source Type: research
Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches
Conclusion: The application of the machine learning methods could identify mRNA/miRNA patterns to discriminate WT from RT. The identified miRNAs/mRNAs panels could offer novel insights into the underlying molecular mechanisms that are responsible for the initiation and development of these cancers. They may provide further insight into the pathogenesis, prognosis, diagnosis, and molecular-targeted therapy in pediatric renal tumors.PMID:37548233 | DOI:10.1080/15513815.2023.2242979 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 7, 2023 Category: Pathology Authors: Seyed Mahdi Hosseiniyan Khatibi Yalda Rahbar Saadat Seyyedeh Mina Hejazian Simin Sharifi Mohammadreza Ardalan Mohammad Teshnehlab Sepideh Zununi Vahed Saeed Pirmoradi Source Type: research
Anthropometric Outcomes in Survivors of Pediatric Solid Tumors
Nutr Cancer. 2023 Aug 6:1-8. doi: 10.1080/01635581.2023.2242104. Online ahead of print.ABSTRACTNutritional status is an important aspect of childhood cancer, with a bearing on the disease and subsequent survivorship. We sought to evaluate the long-term anthropometric outcomes in a cohort of pediatric solid tumor survivors treated between 1994 and 2016. Anthropometry was noted at the time of presentation, after completion of therapy, and at the last follow-up. The z-scores for weight-for-age, height-for-age, and BMI-for-age were calculated using WHO growth charts for ages <5 years and the Indian Academy of Pediatrics gro...
Source: Nutrition and Cancer - August 7, 2023 Category: Cancer & Oncology Authors: Mehak Sehgal Vishesh Jain Sandeep Agarwala Anjan Dhua Prabudh Goel Devendra Kumar Yadav Sameer Bakhshi Mani Kalaivani Source Type: research
Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches
Conclusion: The application of the machine learning methods could identify mRNA/miRNA patterns to discriminate WT from RT. The identified miRNAs/mRNAs panels could offer novel insights into the underlying molecular mechanisms that are responsible for the initiation and development of these cancers. They may provide further insight into the pathogenesis, prognosis, diagnosis, and molecular-targeted therapy in pediatric renal tumors.PMID:37548233 | DOI:10.1080/15513815.2023.2242979 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 7, 2023 Category: Pathology Authors: Seyed Mahdi Hosseiniyan Khatibi Yalda Rahbar Saadat Seyyedeh Mina Hejazian Simin Sharifi Mohammadreza Ardalan Mohammad Teshnehlab Sepideh Zununi Vahed Saeed Pirmoradi Source Type: research
Anthropometric Outcomes in Survivors of Pediatric Solid Tumors
Nutr Cancer. 2023 Aug 6:1-8. doi: 10.1080/01635581.2023.2242104. Online ahead of print.ABSTRACTNutritional status is an important aspect of childhood cancer, with a bearing on the disease and subsequent survivorship. We sought to evaluate the long-term anthropometric outcomes in a cohort of pediatric solid tumor survivors treated between 1994 and 2016. Anthropometry was noted at the time of presentation, after completion of therapy, and at the last follow-up. The z-scores for weight-for-age, height-for-age, and BMI-for-age were calculated using WHO growth charts for ages <5 years and the Indian Academy of Pediatrics gro...
Source: Nutrition and Cancer - August 7, 2023 Category: Cancer & Oncology Authors: Mehak Sehgal Vishesh Jain Sandeep Agarwala Anjan Dhua Prabudh Goel Devendra Kumar Yadav Sameer Bakhshi Mani Kalaivani Source Type: research
Decoding the Possible Molecular Mechanisms in Pediatric Wilms Tumor and Rhabdoid Tumor of the Kidney through Machine Learning Approaches
Conclusion: The application of the machine learning methods could identify mRNA/miRNA patterns to discriminate WT from RT. The identified miRNAs/mRNAs panels could offer novel insights into the underlying molecular mechanisms that are responsible for the initiation and development of these cancers. They may provide further insight into the pathogenesis, prognosis, diagnosis, and molecular-targeted therapy in pediatric renal tumors.PMID:37548233 | DOI:10.1080/15513815.2023.2242979 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 7, 2023 Category: Pathology Authors: Seyed Mahdi Hosseiniyan Khatibi Yalda Rahbar Saadat Seyyedeh Mina Hejazian Simin Sharifi Mohammadreza Ardalan Mohammad Teshnehlab Sepideh Zununi Vahed Saeed Pirmoradi Source Type: research
