Impaired vagal adaptation to an exercise task in women with gestational diabetes mellitus versus women with uncomplicated pregnancies
Hormones (Athens). 2021 Jul 26. doi: 10.1007/s42000-021-00311-4. Online ahead of print.ABSTRACTPURPOSE: Gestational diabetes mellitus (GDM) is associated with an increased risk for maternal and fetal complications. Patients with GDM have an increased cardiovascular risk in later life. The aim of this study was to investigate cardiac autonomic nervous system (ANS) function at rest and during exercise in women with GDM vs. women with uncomplicated pregnancies.METHODS: Thirty-six normotensive pregnant women (21 with GDM and 15 age- and parity-matched women with an uncomplicated pregnancy) were enrolled in this case-control st...
Source: Hormones - July 26, 2021 Category: Endocrinology Authors: Marieta P Theodorakopoulou Areti Triantafyllou Andreas Zafeiridis Afroditi Κ Boutou Iris Grigoriadou Evangelia Kintiraki Stella Douma Dimitrios G Goulis Konstantina Dipla Source Type: research

A manless adultery: the story of Bassa as related in a Marcus Valerius Martialis' epigram
Hormones (Athens). 2021 Jul 23. doi: 10.1007/s42000-021-00310-5. Online ahead of print.ABSTRACTDuring the Golden Age of the Roman Empire, Rome was transformed into a magnificent city where architecture, the arts, and commerce flourished. An inconceivable amount of wealth was accumulated by a handful of noble families, while the masses starved. In such a context, moral values inevitably decline, while sexual mores are liberalized and ever more veer towards salacity. This reality was elegantly illustrated in short, often sarcastic poems known as epigrams. Herein, we present a case of a woman with enigmatic appearance of the ...
Source: Hormones - July 23, 2021 Category: Endocrinology Authors: Georgios K Markantes Maria I Stamou Konstantina Barouti Danai Georgakopoulou Vasiliki Vasileiou Neoklis A Georgopoulos Source Type: research

Outcomes of transsphenoidal surgery in dopamine agonist-resistant prolactinomas: a retrospective study
In this study, we retrospectively analyzed the outcomes of DA-resistant prolactinoma patients after transsphenoidal surgery (TSS).METHODS: A total of 94 consecutive patients with DA-resistant prolactinomas who underwent TSS were retrospectively enrolled in the present study. Early postoperative remission rate, prolactin (PRL) levels, and recurrence rate were analyzed.RESULTS: Of 94 DA-resistant patients, 47 (50%) achieved early remission 1 week post-surgery, including 41.18% of macroprolactinoma patients and 73.08% of microprolactinoma patients. PRL levels on the first postoperative day were significantly lower than preoperative PRL levels (p
Source: Hormones - July 18, 2021 Category: Endocrinology Authors: Liguang Wei Xialin Wei Source Type: research

Accuracy of the dexamethasone suppression test for the prediction of autonomous cortisol secretion-related comorbidities in adrenal incidentalomas
Hormones (Athens). 2021 Jul 17. doi: 10.1007/s42000-021-00308-z. Online ahead of print.ABSTRACTPURPOSE: The aim of this study was to evaluate the diagnostic accuracy of the 1 mg dexamethasone suppression test (DST) for the prediction of autonomous cortisol secretion (ACS)-related comorbidities in patients with adrenal incidentalomas (AIs).METHODS: This was a retrospective multicenter study. We recruited patients with AI/s ≥ 1 cm, excluding those who, during the study, were found during the extension study of an extra-adrenal cancer, with a known diagnosis of hereditary syndromes characterized by adrenal tumors, those pr...
Source: Hormones - July 17, 2021 Category: Endocrinology Authors: Marta Araujo-Castro Paola Parra Ram írez Cristina Robles L ázaro Rogelio Garc ía Centeno Paola Gracia Gimeno Mariana Tom é Fernández-Ladreda Miguel Antonio Sampedro N úñez M ónica Marazuela H éctor F Escobar-Morreale Pablo Valderrabano Source Type: research

Effect of exercise intensity and duration on the levels of stress hormones and hypothalamic-pituitary-gonadal axis in adult male rats: an experimental study
CONCLUSION: These results confirmed the effects of different intensities and durations of exercise on sex hormone levels.PMID:34258750 | DOI:10.1007/s42000-021-00303-4 (Source: Hormones)
Source: Hormones - July 14, 2021 Category: Endocrinology Authors: Nazli Khajehnasiri Mehdi Banitalebi Dehkordi Hossein Amini-Khoei Motahareh Sadat Mirhaj Mohammadabadi Reihaneh Sadeghian Source Type: research

Comparison of the effects of medical and surgical treatments in giant prolactinoma: a single-center experience
CONCLUSION: In our study, it was observed that medical therapy was effective and safe in patients with giant prolactinomas. The use of surgical treatment should be limited to prolactinomas with compression or post-resistance to medical treatment in serious cases.PMID:34236607 | DOI:10.1007/s42000-021-00307-0 (Source: Hormones)
Source: Hormones - July 8, 2021 Category: Endocrinology Authors: Soner Cander Ozen Oz Gul Eda Eylemer Elif Gullulu Boz Elif Gunes Bahattin Hakyemez Selcuk Yilmazlar Canan Ersoy Source Type: research

Oxyphil cells in primary hyperparathyroidism: a clinicopathological study
CONCLUSIONS: Our study suggests that phosphocalcic metabolism is not influenced by the presence of a high content of OxC in the parathyroid glands. A high content of OxC seems to be exclusive to pathologic glands and could be related to the deterioration of renal function in patients with PHPT.PMID:34228313 | DOI:10.1007/s42000-021-00305-2 (Source: Hormones)
Source: Hormones - July 6, 2021 Category: Endocrinology Authors: Ángela De la Hoz Rodríguez Jos é Luis Muñoz De Nova Patricia Mu ñoz Hernández Álvaro Valdés de Anca Rosario Serrano Pardo Rodrigo Tovar P érez Elena Mart ín-Pérez Source Type: research

Association of growth hormone deficiency (GHD) with anxiety and depression: experimental data and evidence from GHD children and adolescents
Hormones (Athens). 2021 Jul 1. doi: 10.1007/s42000-021-00306-1. Online ahead of print.ABSTRACTAnxiety and depression are among the commonest emotional problems in children and young adolescents. They are encountered with even higher prevalence in children and adults with growth hormone deficiency (GHD). Alterations in the somatotropic axis, as observed in both GH/IGF1 deficiency and excess, can produce permanent changes in brain tissue structure. The growth hormone/insulin-like growth factor 1 (GH/IGF1) axis seems to exert a regulatory effect on brain function and neurogenesis, especially in the hippocampus, a brain region...
Source: Hormones - July 1, 2021 Category: Endocrinology Authors: Fotini-Heleni Karachaliou Kyriaki Karavanaki Aristofania Simatou Eleni Tsintzou Nikitas S Skarakis Christina Kanaka-Gatenbein Source Type: research

Clinical relevance of tumor consistency in pituitary adenoma
CONCLUSIONS: Preoperative knowledge of PA consistency affords the neurosurgeon substantial benefit, which clearly appears to be relevant to surgical planning, risks, and surgery outcomes. It could also encourage the centralization of these high complexity tumors in reference centers. Further studies may be enhanced by applying standard consistency classification of the PA and analyzing a more extensive and prospective series of fibrous PA.PMID:34148222 | DOI:10.1007/s42000-021-00302-5 (Source: Hormones)
Source: Hormones - June 20, 2021 Category: Endocrinology Authors: Alberto Acitores Cancela V íctor Rodríguez Berrocal H éctor Pian Juan Salvador Mart ínez San Millán Juan Jos é Díez Pedro Iglesias Source Type: research

The role of estradiol in the immune response against COVID-19
Hormones (Athens). 2021 Jun 17. doi: 10.1007/s42000-021-00300-7. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the pathogen agent causing coronavirus disease (COVID)-19, which was declared a global pandemic in 2020. The spike protein of this virus and the angiotensin-converter enzyme (ACE)-2 in host cells in humans play a vital role in infection and in COVID-19 pathogenesis. Estradiol is known to modulate the actions of immune cells, and, therefore, the antiviral mechanisms of these cells could also be modified by this hormone stimulus. Even though estradiol is not considered...
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Adri án Ramírez-de-Arellano Jorge Guti érrez-Franco Erick Sierra-Diaz Ana Laura Pereira-Su árez Source Type: research

Novel presentation of the c.1856A   & gt;  G (p.Asp619Gly) TSHR gene-activating variant: relapsing hyperthyroidism in three subsequent generations manifesting in early childhood and an in vitro functional study
CONCLUSIONS: Unlike Graves' disease, familial non-autoimmune hyperthyroidism cases present with antithyroid drug-dependence. Not ultrasound but positive thyroglobulin serum concentration indicated residual thyroid tissue. Early detection of residual thyroid tissue and radioiodine ablation prevented the subject from experiencing relapsing hyperthyroidism and undergoing unnecessary repeated surgery. Life-long hormone substitution should be adjusted to free thyroxine rather than TSH serum concentrations.PMID:34142359 | DOI:10.1007/s42000-021-00299-x (Source: Hormones)
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Martin Bezdicka Petra Kleiblova Jiri Soucek Marianna Borecka Eva El-Lababidi Daniel Smrz Michal Rataj Zdenek Sumnik Jana Malikova Ondrej Soucek Source Type: research

Sialadenitis as a complication of radioiodine therapy in patients with thyroid cancer: where do we stand?
CONCLUSION: RAI-induced sialadenitis has a major impact on patients' quality of life. Due to the good prognosis of DTC, the reduction of sialadenitis and its prognosis, prevention, and treatment constitute a priority for the overall treatment of these patients. Further studies that will establish a coherent treatment protocol for this condition are necessary.PMID:34143403 | DOI:10.1007/s42000-021-00304-3 (Source: Hormones)
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Marios Adramerinas Dimitrios Andreadis Konstantinos Vahtsevanos Athanasios Poulopoulos Kalliopi Pazaitou-Panayiotou Source Type: research

The role of estradiol in the immune response against COVID-19
Hormones (Athens). 2021 Jun 17. doi: 10.1007/s42000-021-00300-7. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the pathogen agent causing coronavirus disease (COVID)-19, which was declared a global pandemic in 2020. The spike protein of this virus and the angiotensin-converter enzyme (ACE)-2 in host cells in humans play a vital role in infection and in COVID-19 pathogenesis. Estradiol is known to modulate the actions of immune cells, and, therefore, the antiviral mechanisms of these cells could also be modified by this hormone stimulus. Even though estradiol is not considered...
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Adri án Ramírez-de-Arellano Jorge Guti érrez-Franco Erick Sierra-Diaz Ana Laura Pereira-Su árez Source Type: research

Novel presentation of the c.1856A   & gt;  G (p.Asp619Gly) TSHR gene-activating variant: relapsing hyperthyroidism in three subsequent generations manifesting in early childhood and an in vitro functional study
CONCLUSIONS: Unlike Graves' disease, familial non-autoimmune hyperthyroidism cases present with antithyroid drug-dependence. Not ultrasound but positive thyroglobulin serum concentration indicated residual thyroid tissue. Early detection of residual thyroid tissue and radioiodine ablation prevented the subject from experiencing relapsing hyperthyroidism and undergoing unnecessary repeated surgery. Life-long hormone substitution should be adjusted to free thyroxine rather than TSH serum concentrations.PMID:34142359 | DOI:10.1007/s42000-021-00299-x (Source: Hormones)
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Martin Bezdicka Petra Kleiblova Jiri Soucek Marianna Borecka Eva El-Lababidi Daniel Smrz Michal Rataj Zdenek Sumnik Jana Malikova Ondrej Soucek Source Type: research

Sialadenitis as a complication of radioiodine therapy in patients with thyroid cancer: where do we stand?
CONCLUSION: RAI-induced sialadenitis has a major impact on patients' quality of life. Due to the good prognosis of DTC, the reduction of sialadenitis and its prognosis, prevention, and treatment constitute a priority for the overall treatment of these patients. Further studies that will establish a coherent treatment protocol for this condition are necessary.PMID:34143403 | DOI:10.1007/s42000-021-00304-3 (Source: Hormones)
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Marios Adramerinas Dimitrios Andreadis Konstantinos Vahtsevanos Athanasios Poulopoulos Kalliopi Pazaitou-Panayiotou Source Type: research

The role of estradiol in the immune response against COVID-19
Hormones (Athens). 2021 Jun 17. doi: 10.1007/s42000-021-00300-7. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the pathogen agent causing coronavirus disease (COVID)-19, which was declared a global pandemic in 2020. The spike protein of this virus and the angiotensin-converter enzyme (ACE)-2 in host cells in humans play a vital role in infection and in COVID-19 pathogenesis. Estradiol is known to modulate the actions of immune cells, and, therefore, the antiviral mechanisms of these cells could also be modified by this hormone stimulus. Even though estradiol is not considered...
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Adri án Ramírez-de-Arellano Jorge Guti érrez-Franco Erick Sierra-Diaz Ana Laura Pereira-Su árez Source Type: research

Novel presentation of the c.1856A   & gt;  G (p.Asp619Gly) TSHR gene-activating variant: relapsing hyperthyroidism in three subsequent generations manifesting in early childhood and an in vitro functional study
CONCLUSIONS: Unlike Graves' disease, familial non-autoimmune hyperthyroidism cases present with antithyroid drug-dependence. Not ultrasound but positive thyroglobulin serum concentration indicated residual thyroid tissue. Early detection of residual thyroid tissue and radioiodine ablation prevented the subject from experiencing relapsing hyperthyroidism and undergoing unnecessary repeated surgery. Life-long hormone substitution should be adjusted to free thyroxine rather than TSH serum concentrations.PMID:34142359 | DOI:10.1007/s42000-021-00299-x (Source: Hormones)
Source: Hormones - June 18, 2021 Category: Endocrinology Authors: Martin Bezdicka Petra Kleiblova Jiri Soucek Marianna Borecka Eva El-Lababidi Daniel Smrz Michal Rataj Zdenek Sumnik Jana Malikova Ondrej Soucek Source Type: research

Anthropometric indicators of insulin resistance
Hormones (Athens). 2021 Jun 13. doi: 10.1007/s42000-021-00296-0. Online ahead of print.ABSTRACTDuring recent years, there have been numerous published reports associating increased circumferences of certain regions of the human body with insulin resistance or increased risk of cardiovascular disease. In the present review, we summarize the findings and conclusions of some of these publications.PMID:34120324 | DOI:10.1007/s42000-021-00296-0 (Source: Hormones)
Source: Hormones - June 13, 2021 Category: Endocrinology Authors: Antonis Polymeris Peter D Papapetrou Source Type: research

Effect of sex hormones on human voice physiology: from childhood to senescence
Hormones (Athens). 2021 May 28. doi: 10.1007/s42000-021-00298-y. Online ahead of print.ABSTRACTThe aim of the present literature review is to describe the influence of sex hormones on the human voice in physiological conditions. As a secondary sexual organ, the larynx is affected by sex hormones and may change considerably over the lifespan. In the current review, sex hormone-related voice modifications occurring during childhood, puberty, the menstrual cycle, pregnancy and senescence are described. The roles of sex hormones (including gonadotropins, testosterone, estrogen, androstenedione, dehydroepiandrosterone, and dehy...
Source: Hormones - May 28, 2021 Category: Endocrinology Authors: Virginia Zamponi Rossella Mazzilli Fernando Mazzilli Marco Fantini Source Type: research