Correction to: Conducting an observational study during an economic crisis: analysis of the treatment and follow-up phase of Greek patients participating in the ExFOS study.
Authors: Aloumanis K, Kapetanos G, Alexandridis T, Drossinos V, Papaioannou N, Greek ExFOS study group Abstract Unfortunately in the original publication, the affiliation of the author N. Papaioannou was incorrectly provided. PMID: 30859430 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - March 14, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

From gut microbiota dysfunction to obesity: could short-chain fatty acids stop this dangerous course?
Authors: Barrea L, Muscogiuri G, Annunziata G, Laudisio D, Pugliese G, Salzano C, Colao A, Savastano S Abstract Study of the interactions between the gut microbiota and brain-gut axis represents a very appealing approach to increasing our knowledge about the mechanisms leading to obesity and obesity-related diseases. The aim of this review is to focus on the effects of short-chain fatty acids (SCFAs), which are the main products of gut microbial fermentation from non-digestible carbohydrates in the colon, on the gut-brain axis. Evidence is accumulating regarding the role of SCFAs in the fine-tuning of the gut-brain...
Source: Hormones - March 8, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Mona Lisa is euthyroid: a modern-day diagnosis.
Authors: Yafi M Abstract Making any medical diagnosis of an individual appearing in an old painting is risky. Throughout history, the famous painting of the Mona Lisa by Leonardo da Vinci has challenged many scientists and physicians to scrutinize this striking and enigmatic female image for the purpose of potentially explaining the woman "behind the smile" and offering a medical diagnosis of her state of health. A recent proposal was that she suffered from severe hypothyroidism and that her asymmetric smile was due to psychomotor retardation. Today, in the twenty-first century, can Mona Lisa get "a ...
Source: Hormones - March 7, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Reviews based on 1st Mediterranean Experts Meeting on the topic "Vitamin D in the prevention of health disparities during adult life".
Reviews based on 1st Mediterranean Experts Meeting on the topic "Vitamin D in the prevention of health disparities during adult life". Hormones (Athens). 2019 Mar 02;: Authors: Kotsa K, Karras S, Zembekakis P Abstract PMID: 30827016 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - March 5, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The effects of acarbose on chemokine and cytokine production in human monocytic THP-1 cells.
CONCLUSION: Our study points to the therapeutic anti-inflammatory potential of acarbose. PMID: 30827017 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - March 5, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A toddler with a novel LEPR mutation.
We present a 3-year-old male patient with severe early-onset obesity whose genetic analysis revealed a homozygous, novel, and pathogenic variant (c.1603+2T>C) in LEPR. PMID: 30778850 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - February 21, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Evaluation of growth and puberty in a child with a novel TBX19 gene mutation and review of the literature.
CONCLUSION: We report a new mutation in the TBX19 gene in a patient with isolated ACTH deficiency. While overgrowth is a known feature of some types of adrenal insufficiencies, including MC2R gene defects and POMC deficiency, it may be a novel feature for TPIT deficiency, as in our patient. PMID: 30747411 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - February 14, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A novel thyroid hormone receptor alpha gene mutation, clinic characteristics, and follow-up findings in a patient with thyroid hormone resistance.
In conclusion, THRA gene mutation should be considered in patients with clinical hypothyroid findings and increased/moderately elevated free T3, decreased/ normal free thyroxine, normal thyroid-stimulating hormone levels, and increased muscle enzymes. PMID: 30747412 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - February 14, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Patients with extra-adrenal malignancies and adrenal lesions have similar rates of subclinical hypercortisolism compared with patients with true adrenal incidentalomas.
Authors: Chrisoulidou A, Rakitzi P, Boudina M, Apostolidou-Kiouti F, Poimenidou E, Papanikolaou A, Devlioti A, Rallis G, Pazaitou-Panayiotou K Abstract OBJECTIVE: During follow-up in cancer patients, adrenal lesions are frequently found by computer tomography imaging. In these patients, the frequency of subclinical Cushing's syndrome (SCS) has not been fully explored. The aim of the present study was to investigate the presence of SCS in cancer patients with adrenal lesions in comparison to patients with true adrenal incidentalomas. DESIGN: We studied 95 patients with adrenal lesions: 57 patients (group A, 20 m...
Source: Hormones - February 11, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Metformin and gut microbiota: their interactions and their impact on diabetes.
Authors: Vallianou NG, Stratigou T, Tsagarakis S Abstract The ratio of human to bacterial cells in the human body (microbiota) is around 1:1. As a result of co-evolution of the host mucosal immune system and the microbiota, both have developed multiple mechanisms to maintain homeostasis. However, dissociations between the composition of the gut microbiota and the human host may play a crucial role in the development of type 2 diabetes. Metformin, the most frequently administered medication to treat patients with type 2 diabetes, has only recently been suggested to alter gut microbiota composition through the increa...
Source: Hormones - February 6, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Patient empowerment and the Mediterranean diet as a possible tool to tackle prediabetes associated with overweight or obesity: a pilot study.
CONCLUSIONS: Implementation of short-term patient empowerment as applied to MD adherence was shown to improve anthropometric and metabolic parameters in prediabetic overweight or obese subjects. This is of considerable importance, given that diet must be the cornerstone of treatment in patients at high risk of developing type 2 diabetes. PMID: 30644069 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 16, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Triple A syndrome: two siblings with a novel mutation in the AAAS gene.
CONCLUSIONS: The unique characteristic of these two cases is the novel mutation in the AAAS gene, which is likely pathogenic. In addition, they showcase the genotype-phenotype variability of the disease, as well as the importance of early identification of the neurologic abnormalities, which can result in early intervention and possibly improved outcomes. PMID: 30612286 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 7, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Reviews based on the 17th "Endorama Meeting".
Reviews based on the 17th "Endorama Meeting". Hormones (Athens). 2018 Dec 07;: Authors: Markou KB, Georgopoulos N Abstract PMID: 30536046 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 13, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The past decade in type 2 diabetes and future challenges.
Authors: Haddad JA, Haddad AN Abstract There is today an exponential increase in prevalence of type 2 diabetes mellitus (T2DM), especially in young people. This downward shift in age of onset of T2DM has been shown by abundant evidence to be due to an increase in obesity among the young, the latter mainly attributable to unhealthy dietary habits and a sedentary lifestyle. It is therefore obvious that the prevention of diabetes rather its treatment is of is paramount importance. In the past decade, because concerns about the safety of antidiabetic agents took precedence over the issue of efficacy, almost all studies...
Source: Hormones - December 9, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Transsphenoidal surgery for pituitary adenomas: early results from a single center.
Authors: Karamouzis I, Caputo M, Mele C, Nuzzo A, Zavattaro M, Car P, Panzarasa G, Prodam F, Marzullo P, Aimaretti G Abstract OBJECTIVE: To evaluate early results of transsphenoidal surgery for pituitary adenomas. DESIGN: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. RESULTS: The majority of patients were male (M/F:...
Source: Hormones - December 7, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Correction to: Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination.
Authors: Sindoni A, Gobitti C, Sulfaro S, Giacomarra V, Borsatti E Abstract The original version of this article unfortunately contained a mistake. The title of this article was rendered incorrectly; the correct title is as follows: Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscles and skin dissemination. PMID: 30515667 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 7, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Guidelines for exercise during normal pregnancy and gestational diabetes: a review of international recommendations.
CONCLUSION: Health professionals must be informed about the correct planning and execution of physical exercise programs so as to safely achieve the maximum effectiveness of exercise-induced health-related benefits in pregnant women. PMID: 30511333 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 6, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Vitamin D basis of Alzheimer's disease: from genetics to biomarkers.
Authors: Dursun E, Gezen-Ak D Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder seen mostly in the elderly population. While to date AD research has focused on either neurochemical disruptions, genetic studies, or the pathological hallmarks, little has been done to establish a novel approach that would encompass all three aspects, one that would overcome the current barriers in AD research and determine the cause of AD and, eventually, discover a treatment. Meanwhile, there have been strong indications in recent years that vitamin D, a secosteroid hormone, and its receptors are fundament...
Source: Hormones - December 1, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Molecular basis of vitamin D action in neurodegeneration: the story of a team perspective.
Authors: Gezen-Ak D, Dursun E Abstract Vitamin D, a secosteroid hormone, has, over the years, mainly been known for its classic role in the maintenance of calcium homeostasis of the human body. However, there is increasing understanding that vitamin D contributes to the regulation of Ca2+ homeostasis, especially via voltage-gated calcium channels, in another major organ that uses calcium, the brain. Almost 30 years ago, the role of dysregulation in the aging brain and in Alzheimer's disease (AD) gave rise to the Ca2+ hypothesis of brain aging and dementia. We thus made calcium homeostasis the starting point of...
Source: Hormones - December 1, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The relationship between urotensin II and insulin resistance in women with gestational diabetes mellitus.
Authors: Calan M, Arkan T, Kume T, Bayraktar F Abstract AIM: Urotensin II (UII), a pluripotent vasoactive peptide, plays a crucial role in development of insulin resistance. Gestational diabetes mellitus (GDM) is a metabolic disorder associated with insulin resistance. The aims of the current study were to compare UII levels in women with or without GDM and to investigate the relationship between UII and insulin resistance in women with GDM. METHODS: A total of 84 women were recruited in this case-control study (42 women with GDM and 42 age- and body mass index (BMI)-matched pregnant women without GDM as contro...
Source: Hormones - November 26, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Noggin levels in nonalcoholic fatty liver disease: the effect of vitamin E treatment.
Authors: Polyzos SA, Kountouras J, Anastasilakis AD, Makras P, Hawa G, Sonnleitner L, Missbichler A, Doulberis M, Katsinelos P, Terpos E Abstract AIM: The evaluation of (a) noggin levels in patients with simple steatosis (SS) vs. nonalcoholic steatohepatitis (NASH) vs. controls, and (b) the effect of combined spironolactone plus vitamin E vs. vitamin E monotherapy on noggin levels in biopsy-proven patients with nonalcoholic fatty liver disease (NAFLD). METHODS: In the case-control study, 15 patients with SS, 16 with NASH, and 24 controls were included. In the randomized controlled trial, NAFLD patients were ass...
Source: Hormones - November 24, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Precocious or early puberty in patients with combined pituitary hormone deficiency due to POU1F1 gene mutation: case report and review of possible mechanisms.
Authors: Baş F, Abalı ZY, Toksoy G, Poyrazoğlu Ş, Bundak R, Güleç Ç, Uyguner ZO, Darendeliler F Abstract Central precocious puberty (CPP) or early puberty (EP) is a rare entity in combined pituitary hormone deficiency (CPHD), the latter caused by mutations in pituitary transcription factor genes. The early onset of puberty in two patients with CPHD with POU1F1 gene mutation was evaluated. A 3-month-old boy was diagnosed with central hypothyroidism, and L-thyroxine was commenced. He was referred for the evaluation of short stature at 20 months of age. Anthropometric evaluation revealed se...
Source: Hormones - November 23, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Adiponectin and vitamin D-binding protein concentrations are independently associated in apparently healthy women but not men: a validation cohort.
Authors: Karras SN, Polyzos SΑ, Tsekmekidou X, Gerou S, Gavana E, Papageorgiou V, Kotsa K Abstract PMID: 30456750 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 21, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

An update on adrenal endocrinology: significant discoveries in the last 10  years and where the field is heading in the next decade.
An update on adrenal endocrinology: significant discoveries in the last 10 years and where the field is heading in the next decade. Hormones (Athens). 2018 Nov 19;: Authors: Kamilaris CDC, Stratakis CA Abstract The last 10 years have produced an amazing number of significant discoveries in the field of adrenal endocrinology. The development of the adrenal gland was linked to specific molecules. Cortisol-producing lesions were associated mostly with defects of the cyclic AMP (cAMP) signaling pathway, whereas aldosterone-producing lesions were found to be the result of defects in aldosterone bi...
Source: Hormones - November 21, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Conducting an observational study during an economic crisis: analysis of the treatment and follow-up phase of Greek patients participating in the ExFOS study.
CONCLUSIONS: ExFOS reproduces the outcomes of EFOS, with a 6.5-year time interval between studies, in comparable cohorts of osteoporotic patients. Data should be interpreted in the context of observational study data collection, although summary statistics computed at each time point may overstate drug effect. PMID: 30430458 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 17, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A decade in female reproduction: an endocrine view of the past and into the future.
Authors: Macut D, Milutinović DV, Rašić-Marković A, Nestorov J, Bjekić-Macut J, Stanojlović O Abstract Over the last decade, huge achievements have been made in the fields of neurophysiology, molecular endocrinology, and biochemistry, as well as in the successful translation of clinical research into diseases into clinical practice. As regards female reproduction, most of the advances made in this area were achieved in gonadal axis regulation, regulation of behavior through sex steroids, reproductive genetics, preservation of ovarian reproductive function, steroid profiling, and metabolic and overall re...
Source: Hormones - November 14, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Unusual presentation of recurrent papillary thyroid microcarcinoma with neck muscle and skin metastasis.
Authors: Sindoni A, Gobitti C, Sulfaro S, Giacomarra V, Borsatti E Abstract PMID: 30415409 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 13, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

SOCS3 as a future target to treat metabolic disorders.
Authors: Pedroso JAB, Ramos-Lobo AM, Donato J Abstract The suppressors of cytokine signaling (SOCS) are a group of eight proteins responsible for preventing excessive cytokine signaling. Among this protein family, SOCS3 has received special attention. SOCS3 expression is important to control certain allergy autoimmune diseases. Furthermore, SOCS3 expression is elevated in obesity and it is involved in the inhibition of leptin and insulin signaling, two important hormones involved in the control of energy metabolism. Therefore, increased SOCS3 expression in obese individuals is associated with several metabolic diso...
Source: Hormones - November 11, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Medical therapy for non-functioning pituitary tumors-a critical approach.
Authors: Tampourlou M, Karapanou O, Vassiliadi DA, Tsagarakis S Abstract Non-functioning pituitary adenomas (NFPAs) are the second most common variant of pituitary tumors. When symptomatic, primary therapy is surgery. Recurrence rates are high. Since many NFPAs express dopamine and somatostatin receptors, medical therapy has been used after surgery in order to prevent recurrence. So far, dopamine agonists have been more widely tested with some promise when introduced immediately after surgery but with less efficacy when introduced later upon tumor regrowth. Currently, the role of medical therapy to prevent tumor re...
Source: Hormones - October 30, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Metabolic syndrome: joint diagnostic criteria and links with comorbidities.
Authors: Katsiki N, Doumas M, Athyros V Abstract PMID: 30368688 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 30, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Prolactin, prolactin disorders, and dopamine agonists during pregnancy.
Authors: Levin G, Rottenstreich A Abstract Pituitary disorders, and especially prolactinomas, are not common among pregnant women, though they tend to occur during a woman's years of fertility. The majority of prolactinoma patients present with infertility and menstruation dysfunction; however, prolactinomas are associated with potentially significant morbidity if they remain unrecognized and untreated. Herein, we survey the role of prolactin and prolactinomas in pregnancy while also outlining the therapeutic approach to prolactinoma during pregnancy. The current literature on the impact of dopamine agonists during...
Source: Hormones - October 21, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Review of mobile applications for optimizing the follow-up care of patients with diabetes.
CONCLUSIONS: The current smartphone applications for DM are characterized by a limited number of participants, a small number of parameters, and a lack of standardization. PMID: 30317460 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 15, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A decade of thyroidology.
Authors: Perros P Abstract Significant scientific progress has been achieved in the past decade in thyroidology driven by scholarly enquiry, unmet patient needs, and investment by the pharmaceutical and diagnostics industry. In this review, nine publications have been selected for their impact in pushing the frontiers of knowledge and understanding. They include new perspectives in the diagnosis, pathophysiology, epidemiology and management of thyroid cancer, understanding of thyroid hormone physiology, and new treatments for Graves' orbitopathy. PMID: 30306416 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 13, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Pediatric endocrinology: an overview of the last decade.
Authors: Ibáñez L, Barouti K, Markantes GK, Armeni AK, Georgopoulos NA Abstract Over the past decade, considerable progress has been made in the field of pediatric endocrinology. However, there is still a long way to go regarding the exploration of novel avenues, such as epigenetics, the changing views on the pathophysiology and derived therapy of specific disorders, and the prevention of prevalent diseases. The next decade will hopefully bring the consolidation of most of those achievements and the development of new pathways for further progress. PMID: 30293227 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 8, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Early life stress and trauma: developmental neuroendocrine aspects of prolonged stress system dysregulation.
Authors: Agorastos A, Pervanidou P, Chrousos GP, Kolaitis G Abstract Experience of early life stress (ELS) and trauma is highly prevalent in the general population and has a high public health impact, as it can trigger a health-related risk cascade and lead to impaired homeostatic balance and elevated cacostatic load even decades later. The prolonged neuropsychobiological impact of ELS can, thus, be conceptualized as a common developmental risk factor for disease associated with increased physical and mental morbidity in later life. ELS during critical periods of brain development with elevated neuroplasticity coul...
Source: Hormones - October 5, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Non-adenomatous sellar lesions: single-centre 10-year experience.
CONCLUSIONS: Although rare, non-adenomatous sellar lesions may be associated with significant causes of morbidity, such as hypopituitarism and visual defects, per se or due to the various treatment modalities employed. Moreover, since the lesions are difficult to distinguish from adenomas, these patients require a careful multidisciplinary approach. PMID: 30284206 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 5, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Iodine intake and chronic autoimmune thyroiditis: a comparative study between coastal and mainland regions in Greece.
Authors: Giassa Τ, Mamali I, Gaki Ε, Kaltsas G, Kouraklis G, Markou ΚΒ, Karatzas T Abstract INTRODUCTION: The purpose of this study was to evaluate the relationship between iodine intake and autoimmune thyroiditis in Chios, an island located in the North East Aegean Sea, in comparison to mainland regions in South Western Greece (SWG). MATERIALS AND METHODS: Urine iodine concentration (UIC), thyroid function (serum TSH, thyroid autoantibodies: anti-TPO and anti-Tg), and thyroid U/S were assessed in 200 subjects (150 females and 50 males) from Chios and 322 subjects (255 females and 67 male...
Source: Hormones - October 1, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Asymptomatic and normocalcemic hyperparathyroidism, the silent attack: a combo-endocrinology overview.
Authors: Anastasilakis DA, Makras P, Polyzos SA, Anastasilakis AD, Part of the COMBO ENDO TEAM: 2017 Abstract Asymptomatic primary hyperparathyroidism (PHPT) and the new variant of PHPT, normocalcemic PHPT, are considered by many physicians as mild, innocuous forms of disease, requiring nothing more than monitoring. Although this may be true in some cases in which the disease does not progress or cause complications, deterioration with more or less severe manifestations may occur. In the present review, we discuss the existing evidence of both the classic (skeletal and renal) and non-classic (cardiovascular, gastro...
Source: Hormones - September 28, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Unilateral renal agenesis as an early marker for genetic screening in Kallmann syndrome.
Authors: Stamou MI, Plummer L, Galli-Tsinopoulou A, Stergidou D, Koika V, Georgopoulos NA PMID: 30255480 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 28, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Growth hormone axis in patients with chronic kidney disease.
Authors: Paschou SΑ, Kanaka-Gantenbein C, Chrousos GP, Vryonidou A PMID: 30255481 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 28, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review.
Authors: Grammatiki M, Karras S, Kotsa K Abstract Diabetes mellitus, a metabolic disorder associated with chronic complications, is traditionally classified into two main subtypes. Type 1 diabetes mellitus (T1DM) results from gradual pancreatic islet β cell autoimmune destruction, extending over months or years. Type 2 diabetes mellitus (T2DM) is a heterogeneous disorder, with both insulin resistance and impairment in insulin secretion contributing to its pathogenesis. Vitamin D is a fat-soluble vitamin with an established role in calcium metabolism. Recently, several studies have provided evidence suggesting ...
Source: Hormones - September 28, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Further data corroborating a pituitary contribution to the genesis of the Cyclopean myth.
Authors: Varotto E, Armocida E PMID: 30229481 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 21, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Lipids: a personal view of the past decade.
Authors: Katsiki N, Mikhailidis DP Abstract The past decade has witnessed considerable progress in the field of lipids. New drugs have been "rapidly" developed and some of these drugs have already been evaluated in event-based large trials. This evidence has led to the guidelines recommending new, more aggressive treatment goals for low-density lipoprotein cholesterol (LDL-C) levels. Although LDL-C remains the principal goal for cardiovascular disease (CVD) risk reduction, there has also been considerable interest in other lipid variables, such as high-density lipoprotein cholesterol, triglycerides, and l...
Source: Hormones - September 21, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Vitamin D and health in the Mediterranean countries.
Authors: Grant WB Abstract Vitamin D, traditionally well known for its role in maintaining optimal health through its contribution to calcium metabolism and skeletal health, has received increased attention over the past two decades, with considerable focus being placed on its nonskeletal benefits. This paper is a narrative review of the nonskeletal health benefits of vitamin D, of particular interest to inhabitants of Mediterranean countries, namely, autism, cancer, cardiovascular disease, chronic obstructive pulmonary disease, dental caries, diabetes mellitus, erectile dysfunction, hypertension, metabolic syndrom...
Source: Hormones - September 15, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Thyroid-stimulating hormone is not the primary regulator of thyroid development in euthyroid children and adolescents living in an iodine-replete area.
Authors: Michalaki MA, Mamali I, Tsekouras A, Vlassopoulou B, Anastasiou E, Koukkou EG, Vagenakis AG, Sakellaropoulos G, Georgopoulos NA, Rashitov M, Azizov B, Ismailov S, Markou KB Abstract OBJECTIVES: It is known that there are multiple factors which can affect thyroid gland development during childhood and adolescence. Our aim was to investigate this issue by examining the relationships between age, sex, several anthropometric parameters, pubertal status, thyroid function tests, and iodine intake status with thyroid volume (TV) in children and adolescents. STUDY DESIGN: This was a cross-sectional field study...
Source: Hormones - September 5, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links.
Authors: Zafar U, Khaliq S, Ahmad HU, Manzoor S, Lone KP Abstract Metabolic syndrome (MetS), today a major global public health problem, is a cluster of clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension, insulin resistance, and dyslipidemias. These MetS-related traits significantly increase the risk of type 2 diabetes mellitus, adverse cardiac events, stroke, and hepatic steatosis. The pathogenesis of MetS is multifactorial, with the interplay of environmental, nutritional, and genetic factors. Chronic low-grade inflammation together with visceral adipose tissue, adipocyte ...
Source: Hormones - September 3, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Gonadotropin-releasing hormone (GnRH) deficiency under treatment: psychological and sexual functioning impacts.
CONCLUSIONS: Our study is the first to investigate psychological and sexual functioning impacts in patients with GnRH deficiency under hormonal replacement therapy. However, larger studies are needed so as to add further empirical evidence. PMID: 30168087 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 1, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Stem cell therapy in erectile dysfunction: science fiction or realistic treatment option?
Authors: Vakalopoulos I, Memmos D, Mykoniatis I, Toutziaris C, Dimitriadis G Abstract Stem cell therapy has become a subject of great interest to researchers worldwide. One of the medical conditions being studied for possible treatment with the use of stem cells is erectile dysfunction, and particularly organic and post-radical prostatectomy erectile dysfunction. However, is stem cell therapy a viable treatment option for erectile dysfunction? The current body of literature provides a wide array of clinical trials performed on animal models simulating different types of human erectile dysfunction. Unfortunately, on...
Source: Hormones - August 24, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Significant effect of group education in patients with diabetes type 1.
Authors: Mouslech Z, Somali M, Sarantis L, Christos D, Alexandra C, Maria P, Mastorakos G, Savopoulos C, Hatzitolios AI Abstract OBJECTIVE: Type 1 diabetes mellitus (T1DM) constitutes a real challenge in everyday practice for both physicians and patients. Due to the complexity of the disease and its unpredictable nature, structured education and training programs are nowadays implemented that ensure active patient involvement and self-care behaviors to achieve adequate glycemic control, prevent diabetic complications, and improve the quality of life of patients. These programs provide patients with the necessary kn...
Source: Hormones - August 18, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The effectiveness of a health promotion and stress-management intervention program in a sample of obese children and adolescents.
CONCLUSIONS: The present study supports the effectiveness of stress management intervention programs on waist-hip ratio reduction. Further research is required to investigate biomarkers able to predict and evaluate the effectiveness of stress management intervention programs. PMID: 30099726 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - August 15, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research