Male precocious puberty described in literature of the Spanish Golden Age.
We present what is, to our knowledge, the first full description in European literature of male precocious puberty and its consequences in an adult. This case is included in a book of the miscellaneous genre of Spanish Renaissance literature (Jardin de Flores Curiosas) written by Antonio de Torquemada in the sixteenth century. PMID: 32037485 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - February 12, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Detection of thyroiditis on PET/CT imaging: a systematic review.
CONCLUSIONS: Diffuse 18F-FDG thyroid uptake is a relatively rare event commonly due to benign diseases, among which thyroiditis is the most common. The rate of neoplastic disease with diffuse 18F-FDG thyroid uptake is very low. Diffuse 18F-FDG thyroid uptake requires further investigation and clinical evaluation for the correct diagnosis. Currently, cases of diffuse thyroid uptake with non-18F-FDG radiotracer are only anecdotal. PMID: 32037486 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - February 12, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Gender dysphoria in children and adolescents: an overview.
Authors: Skordis N, Kyriakou A, Dror S, Mushailov A, Nicolaides NC Abstract Over the last decade, we have witnessed considerable progress in gender dysphoria (GD) terminology in an attempt to better describe the condition based on certain criteria. The ever-increasing social acceptance and destigmatization of children and adolescents with GD have resulted in an increased number of transgender individuals seeking endocrine care. In addition to terminology and diagnostic criteria, the tremendous progress of genetics and neuroimaging has enabled us to have a deeper understanding of the complex pathogenesis of GD. Alth...
Source: Hormones - February 6, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

An early scientific report on acromegaly: solving an intriguing endocrinological (c)old case?
We present and discuss a late-nineteenth century clinical case described by Professor Taruffi in a scientific paper titled "Scheletro con prosopoectasia e tredici vertebre dorsali" (Skeleton with prosopoectasia and thirteen thoracic vertebrae). Taruffi could not explain the disproportionate skeletal and visceral growth, and the case could therefore be considered an unrecognized case of acromegaly. The anatomopathological specimens and the wax model cited in the paper are currently hosted at the "Luigi Cattaneo" Anatomical Wax Collection of Bologna University; however, some inaccuracies and uncertainties...
Source: Hormones - February 2, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Metabolic and catecholamine response to sympathetic stimulation in early-treated adult male patients with phenylketonuria.
CONCLUSION: PKU itself might not influence stress-induced catecholamine changes. Only strenuous exercise increased blood Phe levels in PKU subjects. PMID: 31993977 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 31, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Selenium involvement in mitochondrial function in thyroid disorders.
Authors: Gheorghiu ML, Badiu C Abstract Selenium (Se), an important oligoelement, is a component of the antioxidant system. Over the last decade, it has been ever more frequently discussed in the context of thyroid disorders. Graves' disease and Hashimoto's thyroiditis, differentiated thyroid cancer, and even endemic goiter may have common triggers that are activated by excess reactive oxygen species (ROS), which are involved in various stages of the pathogenesis of thyroid disorders. Most oxidative events occur in mitochondria, organelles that contain enzymes with Se as a cofactor. Mitochondria are responsible for...
Source: Hormones - January 23, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Bicentennial of the discovery of selenium commemorated at the Museum of Natural History in Athens.
Authors: Duntas LH, Dumont J PMID: 31960359 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 23, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Multiple hormone secretion may indicate worse prognosis in patients with ectopic Cushing's syndrome.
CONCLUSIONS: Multiple hormone secretion, high morning cortisol, higher tumor grade, and diabetes were correlated with shorter OS. Development of ECS in patients with a non-functioning NEN may indicate tumor progression. Multiple hormone secretion should be considered as a bad prognostic sign in ECS patients and should lead to intensified clinical management. PMID: 31950464 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 19, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Pituitary tumors: epidemiology and clinical presentation spectrum.
Authors: Araujo-Castro M, Berrocal VR, Pascual-Corrales E Abstract Pituitary tumors (PTs) are a heterogeneous group of lesions of the central nervous system that are usually benign. Most of them occur sporadically, but 5% can do so within family syndromes, usually at a young age. There are differences by sex, age, race, and genetic factors in the prevalence of different tumor cell types and clinical presentation. Functioning-PTs (FPTs) are usually diagnosed earlier than non-functioning PTs (NFPTs). However, this depends on the PT type. Headaches and visual disturbances are the most frequent mass-effect symptoms, bu...
Source: Hormones - January 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The effects of postnatal exposure of endocrine disruptors on testicular function: a systematic review and a meta-analysis.
Authors: Bliatka D, Nigdelis MP, Chatzimeletiou K, Mastorakos G, Lymperi S, Goulis DG Abstract BACKGROUND: Despite many epidemiological studies having been conducted, the impact of postnatal exposure of endocrine disruptors (EDs) on testicular function remains a controversial issue. AIM: To systematically review the literature and perform a quantitative synthesis to evaluate the effect of EDs on testicular function. MATERIALS AND METHODS: A comprehensive search was conducted in the MEDLINE, Scopus, and CENTRAL databases. Eligible for the systematic review were observational (cross-sectional and cohort) stud...
Source: Hormones - January 13, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Correction to: A year in type 2 diabetes mellitus: 2018 review based on the Endorama lecture.
Authors: Paschou SA, Alexandrides T Abstract The original version of this article, published on 26 November 2019, contained a mistake. An author's name was misspelled. PMID: 31919676 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 11, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The measurement of vitamin D metabolites: part I-metabolism of vitamin D and the measurement of 25-hydroxyvitamin D.
Authors: Makris K, Sempos C, Cavalier E Abstract It has been more than 80 years since the discovery of vitamin D and its ability to cure rickets in children. Vitamin D is a secosteroid and comes in two distinct forms, vitamin D2 and vitamin D3. During the last 40 years, the synthesis and metabolism of vitamin D were elucidated and more than 50 metabolites of vitamin D have been discovered, though commercial measurement procedures have been developed for only a few of them. The clinical significance of vitamin D in calcium and phosphorus homeostasis is well appreciated. However, recent epidemiological data...
Source: Hormones - January 11, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Correction to: Reduced Foxo3a, FoxL2, and p27 mRNA expression in human ovarian tissue in premature ovarian insufficiency.
Authors: Thanatsis N, Kaponis A, Koika V, Georgopoulos NA, Decavalas GO Abstract The original version of this article, published 21 October 2019, unfortunately contained a mistake. The presentation of Fig. 1 was incorrect. The corrected figure is given below. PMID: 31912384 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - January 10, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Association between vitamin D and endometriosis: a systematic review.
CONCLUSIONS: This is a systematic attempt to collect, evaluate, and present the known data on the association between vit D and endometriosis. Given the heterogeneity and the diversity of the present studies, more research is required to elucidate the association between vit D and endometriosis. PMID: 31863346 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 22, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Salt intake in mineralocorticoid receptor antagonist-treated primary aldosteronism: foe or ally?
Authors: Fountoulakis S, Papanastasiou L, Voulgaris N, Kounadi T, Markou A, Chrousos GP, Piaditis G Abstract Mild hyperkalemia is a common side effect of mineralocorticoid receptor antagonist (MRA) treatment of patients with primary aldosteronism (PA), which can be worsened by instructions to minimize salt intake. Our objective was to evaluate the effect of salt consumption on serum potassium levels and mean, mean minimal, and mean maximal systolic and diastolic blood pressure (BP) in MRA-treated hyperkalemic PA patients under relative salt restriction. Seventeen consecutive mildly hyperkalemic MRA-treated PA patie...
Source: Hormones - December 22, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Does exercise-induced apelin affect sarcopenia? A systematic review and meta-analysis.
CONCLUSION: Further studies are needed to clarify in greater detail the effect of resistance exercise on apelin levels, including data on frequency, type, intensity, and time of aerobic exercise, to compare their effects on sarcopenia and cognitive disorders. PMID: 31853817 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 21, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Bone health care in women with breast cancer.
The objective is to provide a sound pathophysiological background along with evidence-based and practical recommendations for physicians managing such women. PMID: 31853818 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 21, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Premature ovarian insufficiency in adolescence: a chance for early diagnosis?
Authors: Michala L, Stefanaki K, Loutradis D Abstract Premature ovarian insufficiency (POI) is typically diagnosed when amenorrhea is combined with high gonadotrophins and hypoestrogenemia in a woman under 40 years of age, although, more rarely, POI can develop in adolescence and present with delayed puberty or amenorrhea, depending on the timing of follicular depletion or insult to the ovary. In a proportion of girls, the diagnosis may be made at an early stage of POI, presenting with abnormal uterine bleeding, when some follicular function is still retained. The natural history of POI in this group of patients is...
Source: Hormones - December 14, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Diagnosis, treatment, and survival analysis of adrenocortical carcinomas: a multicentric study.
CONCLUSION: This study reinforces the dismal prognosis of ACC, the need for long-term follow-up, and tumor stage as the most important survival predictor. Reviewing medical records in such rare conditions is an opportunity to identify insufficiencies and to improve medical care. PMID: 31823340 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 13, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The other view: the trace element selenium as a micronutrient in thyroid disease, diabetes, and beyond.
Authors: Schomburg L Abstract Antibiotics are provided for infections caused by bacteria, and statins help to control hypercholesterolemia. When hungry, you need to eat, and when you are deficient in a particular nutrient, the diet should be chosen wisely to provide what is missing. In the matter of providing the essential trace element selenium (Se), there are two different but partly overlapping views on its nature and requirements. Some consider it a medication that should be given to a subset of more or less well-defined (thyroid) patients only, in order to alleviate symptoms, to improve the course of the disea...
Source: Hormones - December 13, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: The findings showed that Se supplementation might reduce oxidative stress by increasing TAC and GPX levels and decreasing serum MDA, both of which are crucial factors for reduction of oxidative stress. PMID: 31820398 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - December 11, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Iodine nutrition in pregnant and breastfeeding women: sufficiency, deficiency, and supplementation.
Authors: Delshad H, Azizi F Abstract Iodine is a micronutrient used by the thyroid gland to produce thyroid hormones, which manage different aspects of body metabolism. Humans depend on exogenous sources of iodine to maintain the normal concentration of thyroid hormones. Pregnancy alters iodine turnover and is associated with significant changes in thyroid function. Daily iodine requirement during pregnancy increases to 250 μg, compared with 150 μg for nonpregnant women. According to recent guidelines of scientific organizations, to improve maternal thyroid status and to prevent child neurocognitive...
Source: Hormones - November 30, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood.
CONCLUSIONS: Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses. PMID: 31768940 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 28, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A novel K224T missense mutation in a patient with MEN1 syndrome.
Authors: Tolin J, Reid L, Somer RA, Morgan FH PMID: 31760587 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 25, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Obese boys with low concentrations of high-density lipoprotein cholesterol are at greater risk of hepatosteatosis.
CONCLUSION: Gender, BMI, and HDL were found to be predictors of steatosis. Male patients with low HDL and high BMI are at greater risk of steatosis and should be carefully examined for the presence of NAFLD. PMID: 31754954 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 24, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Online health information-seeking behavior by endocrinology patients.
Authors: Kyriacou A, Sherratt C Abstract PURPOSE: Given that the Internet is important for health-related information (HRI) and the fact that online health information (OHI)-seeking behavior has never been studied in endocrinology, we set out to examine how and why the Internet is utilized for HRI, the frequency of such activity, its impact, future information needs, and the effect of language. METHODS: A mainly quantitative, embedded mixed-methods study was performed, employing a questionnaire survey. We included 312 patients (78.4% response rate). RESULTS: OHI-seeking was reported by 175 patients (56.1%),...
Source: Hormones - November 23, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The impact of thyroid diseases starting from birth on reproductive function.
Authors: Krassas GE, Markou KB Abstract The aim of this review is to provide relevant information regarding the impact of thyroid disease, starting from birth and mainly concerning hyperthyroidism and hypothyroidism, on reproduction. Hyperthyroidism occurs much less commonly in children than hypothyroidism, with Graves' disease (GD) being the most common cause of thyrotoxicosis in children. Children born with neonatal GD have no defects in the reproductive system that could be related to hyperthyroidism. Current treatment options include antithyroid drugs (ATD), surgery, and radioactive iodine (RAI). In males, norm...
Source: Hormones - November 18, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Role of the small proteoglycan bikunin in human reproduction.
CONCLUSIONS: Because of its pleiotropic roles in several reproductive events and its association with some life-threatening pathological conditions of pregnancy, bikunin may represent a non-invasive marker for improving follow-up and early diagnosis. Studies showing its usefulness as a drug for reducing the risk of preterm delivery and improving neonatal outcomes have yielded interesting results that deserve to be investigated through further research. PMID: 31728877 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 17, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Improvement of metabolic control after 3-month use of real-time continuous glucose monitoring in patients with type 1 diabetes: a multicenter study in Greece.
Authors: Eleftheriadou I, Didangelos T, Pappas AC, Anastasiou E, Vasilopoulos C, Zoupas C, Manes C, Tsatsoulis A, Benroubi M, Pangalos E, Thomakos P, Gerasimidi-Vazeou A, Tentolouris N Abstract PURPOSE: To assess the efficacy of a real-time continuous glucose monitoring (RT-CGM) system added to insulin pump therapy for 3 months, in sub-optimally controlled adults with type 1 diabetes mellitus (T1D). METHODS: This was a prospective, multicenter, non-randomized, post-market release study. A total of 43 adult patients with T1D on insulin pump therapy and inadequate glycemic control (HbA1c> 7.0%) participated in...
Source: Hormones - November 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Challenges and perspectives of selenium supplementation in Graves' disease and orbitopathy.
CONCLUSIONS: Additional randomized clinical trials with clinically relevant endpoints are urgently needed to further aid in clinical decision-making, including better stratification of Graves' disease patients, who are most likely to benefit from Se supplementation. PMID: 31721133 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Glucose metabolism disorders in patients with adrenal gland disorders: pathophysiology and management.
Authors: Ioakim KJ, Sydney GI, Paschou SA Abstract The aim of this review is to explore and discuss disorders of glucose metabolism that can arise in individuals with adrenal gland disorders, as well as to enumerate the available therapeutic treatments for these while considering their benefits and drawbacks. Hyperfunctioning adrenal glands, as in hypercortisolism, hyperaldosteronism, and malignancy, or hypofunctioning of adrenal glands, as in adrenal insufficiency, can lead to carbohydrate metabolism dysregulation with subsequent glucometabolic repercussions, either hyperglycemia or hypoglycemia. Glycemic disorder...
Source: Hormones - November 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Acidophil stem cell pituitary adenoma: a case report and literature review.
We present the case of 33-year-old woman with a history of amenorrhea, galactorrhea, elevated prolactin levels, and pituitary tumor. Despite suppression of prolactin levels with cabergoline, the pituitary tumor continued to increase in size and the patient developed clinical symptoms and biochemistry consistent with the diagnosis of acromegaly due to acidophilic stem cell adenoma, an extremely rare subtype of mixed growth hormone/prolactin adenoma, which behaves more aggressively and has a lower surgical cure rate compared to the pure GH-secreting adenoma. The patient had in vitro fertilization 2 years after the successful...
Source: Hormones - November 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Pregnancy, thyroid, and the potential use of selenium.
Authors: Hubalewska-Dydejczyk A, Duntas L, Gilis-Januszewska A Abstract The management of pregnant women is a major concern of health care around the world. There is growing evidence regarding the influence of selenium (Se) on pregnancy and fetus outcomes. However, due to as yet insufficient evidence, lack of measurable markers to assess the effect of Se supplementation on the human metabolism, and Se's narrow therapeutic index, the majority of experts and the current guidelines published by several scientific societies do not recommend the use of Se in pregnancy and in women of childbearing age. Further research b...
Source: Hormones - November 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Is MGMT the best marker to predict response of temozolomide in aggressive pituitary tumors? Alternative markers and prospective treatment modalities.
Authors: Kontogeorgos G, Thodou E PMID: 31721137 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Comment on the systematic review and meta-analysis titled "Gestational diabetes and the risk of cardiovascular disease in women".
Comment on the systematic review and meta-analysis titled "Gestational diabetes and the risk of cardiovascular disease in women". Hormones (Athens). 2019 Nov 12;: Authors: Paschou SA, Sydney GI, Ioakim KJ, Kotsa K, Goulis DG PMID: 31713724 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 14, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Evidence for a manifold role of selenium in infertility.
Authors: Mintziori G, Mousiolis A, Duntas LH, Goulis DG Abstract This review aimed to assess the evidence from observational and interventional studies in humans and animals regarding the role of selenium (Se) in male and female infertility. As oxidative stress can seriously impair male, and possibly also female, reproductive functions, it can be speculated that the antioxidant properties of Se could constitute one of the pathways by which this element is involved in fertility. Specifically, there are strong indications that Se influences the growth, maturation, and replication of oocytes, though the precise mechan...
Source: Hormones - November 10, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The role of cellular senescence in diabetes mellitus and osteoporosis: molecular pathways and potential interventions.
Authors: Giovos G, Yavropoulou MP, Yovos JG Abstract The improving effectiveness of health care leads inevitably to a rapid increase in the elderly population worldwide. At advanced ages, however, people experience chronic disabilities, which significantly increase the social and economic burden while curtailing survival, independence, and quality of life of the aging population. As aging is a multifactorial process, apart from genetic predisposition, other environmental factors, such as chronic sterile inflammation and cellular senescence, contribute as crucial participants and have been targeted to reverse their ...
Source: Hormones - November 10, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Pediatric growth hormone therapy in Greece: analysis of the Hellenic cohort of the GeNeSIS study.
CONCLUSIONS: In the Greek cohort of GeNeSIS, GHD is the most frequent indication for GH treatment, followed by TS. While the latter is diagnosed somewhat earlier, GH treatment is not as efficacious as for patients with GHD. No major safety issues were reported during follow-up. The results, which are in accordance with the international literature, should be interpreted in the context of observational studies. PMID: 31696446 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 8, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Increased circulating levels of irisin are associated with cardiovascular risk factors in subjects with acromegaly.
CONCLUSIONS: Elevated irisin levels in acromegalic subjects were associated with cIMT and EFT, suggesting that irisin is a surrogate marker for cardiovascular risk in acromegalic subjects. PMID: 31696447 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - November 8, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Neck mass and tracheostomy in a young lady depicted by Piero di Cosimo.
Authors: Grau JJ, Caballero M, Garrido C, Canalda S, Trilla A Abstract Among surgical procedures currently in use, tracheostomy has a particularly long history. The first written description of the procedure is due to Brasavola, and dates from 1546. Piero di Cosimo (1462-1522) was an early Renaissance painter who painted a work traditionally known as Cephalus and Procris or The Death of Procris (1495-1500). In this painting, a vertical tracheostomy can be observed in a young woman lying on the ground. A giant mass can be seen in the lower left neck with superficial venous vessels, suggesting a thyroid malignancy. T...
Source: Hormones - November 8, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Potential clinical variants detected in mitochondrial DNA D-loop hypervariable region I of patients with non-alcoholic steatohepatitis.
CONCLUSION: These findings suggest that NASH may be associated with D-loop nucleotide variations and that microRNA-based in vitro and/or in vivo studies may be developed by targeting the D-loop variants. PMID: 31656024 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 29, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Reduced Foxo3a, FoxL2, and p27 mRNA expression in human ovarian tissue in premature ovarian insufficiency.
CONCLUSIONS: Our findings suggest a possible role of Foxo3a, FoxL2, and p27 in the pathogenesis of human POI, which may prove to be of great diagnostic-therapeutic value. Further larger studies are needed to identify a similar pattern for AMH, PTEN, and AMHR2 and to investigate gene expression at a protein level. PMID: 31637660 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 24, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Portrait of the Countess Anastasia Spini (1842): acromegaly in art.
Authors: Fogacci F, Borghi C, Cicero AFG PMID: 31630371 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 22, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A year in type 2 diabetes mellitus: 2018 review based on the Endorama lecture.
Authors: Paschou SΑ, Alexandrides T Abstract The aim of this article is to review and present the most important studies published in the field of type 2 diabetes mellitus (T2DM) during 2018. These studies were presented in a lecture given on this topic at the Endorama Meeting in Patras, Greece, in January 2019. In order to identify the most important and relevant articles, a search in the English language was conducted in PubMed for publications up to the end of December 2018, with special attention paid to publications in high impact factor journals. The highlights of the main Diabetes Meetings [ADA (Americ...
Source: Hormones - October 22, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Asporin levels are low in patients with nonalcoholic fatty liver disease and increase after vitamin E treatment.
Authors: Polyzos SA, Hawa G, Jungwirth T, Karabouta Z, Kountouras J PMID: 31628635 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 21, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The relationship between estimated glomerular filtration rate and urine m/creatinine ratio and parathyroid hormone in elderly Koreans.
This study aimed to assess the relationship between estimated glomerular filtration rate (eGFR), urine microalbumin/creatinine ratio (uACR), and parathyroid hormone (PTH) levels in elderly Korean men and women. Data were analyzed from 2880 adults (1262 men and 1618 women) aged ≥ 50 years from the Fifth Korean National Health and Nutrition Examination Survey V-2 (KNHANES V-2). In men, after adjusting for related variables, the odds ratios (ORs) of the high PTH levels (PTH> 78.0 ng/L) were significantly higher in the decreased eGFR group [eGFR
Source: Hormones - October 19, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Decreased adipocyte glucose transporter 4 (GLUT4) and aquaglyceroporin-7 (AQP7) in adults with morbid obesity: possible early markers of metabolic dysfunction.
CONCLUSIONS: Decreased 37 kDa (presented in this study as a novel isoform) and 34 kDa isoforms of AQP7 in MOW and MODM may cause reduced lipolysis, enhancement of adipocyte hypertrophy, and impairment of insulin, signaling possibly reflected by low GLUT4 expression. This may potentially cause systemic IR, since decreased adipose GLUT4 expression may affect whole-body insulin sensitivity, increasing the risk for DM2. Furthermore, decreased subcutaneous AQP7 34 kDa could represent an early marker of IR. PMID: 31588962 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 9, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Neurocognitive impairment in type 2 diabetes mellitus.
Authors: Karvani M, Simos P, Stavrakaki S, Kapoukranidou D Abstract There is emerging evidence that cognitive impairment could be a diabetes mellitus-related complication. It has been suggested that diabetic people are at increased risk of cognitive decline, since the metabolic and vascular disturbances of the disease affect brain function. Additionally, prolonged exposure to olther potential detrimental factors leads to irreversible cognitive decrements over time due to the aging process. Neurocognitive impairment signifies decreased performance in cognitive domains such as verbal and nonverbal memory, both immedi...
Source: Hormones - September 17, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Swimming modifies the effect of noise stress on the HPG axis of male rats.
CONCLUSIONS: Long-term exposure to noise is known to have a negative impact on male sex hormones, while submaximal swimming exercise is likely to reduce these effects and improve HPG axis hormones. PMID: 31515712 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 15, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Selenium and selenoprotein P in nonalcoholic fatty liver disease.
Authors: Polyzos SA, Kountouras J, Goulas A, Duntas L Abstract Conflicting data link nonalcoholic fatty liver disease (NAFLD), a disease with no currently approved treatment, with selenium (Se) and selenoprotein P (SELENOP), a glycoprotein synthesized and primarily secreted by the hepatocytes, functioning as a Se transporter from the liver to other tissues. This review aims to summarize the evidence between Se, SELENOP, and NAFLD, which may hopefully clarify whether current data on Se and SELENOP in NAFLD warrant further investigation for their diagnostic and therapeutic potential. Most, albeit not all, experimenta...
Source: Hormones - September 8, 2019 Category: Endocrinology Tags: Hormones (Athens) Source Type: research