Thyroxine replacement modifies changes in deiodinase and thyroid hormone transporter expression induced by subclinical hypothyroidism in rats.
CONCLUSION: Our results indicate that treatment of SCH should be considered before the appearance of clinical symptoms of hypothyroidism. PMID: 32996026 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - October 1, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The placebo phenomenon and the underlying mechanisms.
Authors: Theodosis-Nobelos P, Filotheidou A, Triantis C Abstract The clinical role of the placebo effect is a topic of increasing interest for the scientific community. Focus is shifting from the inert role of placebos in randomized controlled trials (RCTs) to potential effects in clinical applications, since the phenomenon is thought to be inherent in routine clinical practice, affecting therapy success rates. Mediation of the mind-brain-body relationship involves both psychosocial and neurobiological factors, the interaction of which comprises the placebo mechanisms. Psychosocial factors include environmentally i...
Source: Hormones - September 18, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Effect of estradiol on enzymes of vascular extracellular nucleotide metabolism.
CONCLUSION: We conclude that estradiol inhibits the extracellular degradation of adenosine to inosine, which may be an element of its vascular protective effect, as it will lead to an increase in extracellular adenosine concentration. We can also assume that during the development of the atherosclerotic process, the protective role of estradiol in the regulation of adenosine degradation may be obscured by other pathogenic factors. PMID: 32935303 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 17, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Leucippus, either male or death: a case of sex reversal by divine intervention.
Authors: Markantes GK, Barouti K, Stamou MI, Georgopoulos NA Abstract The concept of metamorphosis (change of form, structure, or substance) is very frequently encountered in Ancient Greek and Roman literature. One of the most striking types of metamorphosis described in many myths is gender transformation, where a man becomes a woman or vice versa. Herein, we present a case of pubertal gender inversion, the marvelous story of the Cretan Leucippus, which not only inspired many ancient writers but also led to the development of a distinct, local, religious cult. A medical interpretation of the myth, whereby we attem...
Source: Hormones - September 17, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A case series of bilateral inferior petrosal sinus sampling with desmopressin in evaluation of ACTH-dependent Cushing's syndrome in Iran.
CONCLUSION: No significant benefits of adding desmopressin to BIPSS were observed. The sensitivity of BIPSS in the diagnosis of CD was high, whereas it has moderate accuracy in tumor lateralization. PMID: 32935305 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - September 17, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Diabetes distress is associated with individualized glycemic control in adults with type 2 diabetes mellitus.
Authors: Theodoropoulou KT, Dimitriadis GD, Tentolouris N, Darviri C, Chrousos GP Abstract PURPOSE: It has been proposed that the negative emotional state of diabetes distress (DD) may exert a detrimental effect on glycemic outcomes of individuals struggling with diabetes-related challenges. Thus far, no study has investigated this association by utilizing individualized treatment targets of patients' glycemic control. Therefore, we sought to identify the potential role of DD in the achievement of individualized glycemic targets (AIGTs) among persons with type 2 diabetes mellitus (T2D). METHODS: This cross-sect...
Source: Hormones - August 28, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical presentation and management of acromegaly in elderly patients.
CONCLUSIONS: Elderly acromegalic patients are not uncommon. Primary medical therapy is a reasonable option and is effectively used, while the rate of surgical success is not reduced. A careful cost-benefit balance is suggested. Disease-specific comorbidities are more prevalent in acromegalic patients with a longer follow-up rather than in those diagnosed aged ≥65 years. PMID: 32840821 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - August 27, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The role of the gut-brain axis in depression: endocrine, neural, and immune pathways.
Authors: Makris AP, Karianaki M, Tsamis KI, Paschou SA Abstract The aim of this article is to summarize the pathways connecting the gut and the brain and to highlight their role in the development of depression as well as their potential use as therapeutic targets. A literature search was conducted in PubMed using relevant keywords and their combinations up to the end of March 2020. Previously seen as a disease pertaining solely to the central nervous system, depression is now perceived as a multifactorial condition that extends beyond neurotransmitter depletion. Central to our understanding of the disease is our c...
Source: Hormones - August 24, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Prevalence of nutritional deficiencies in bariatric surgery candidates and its effect on metabolic status.
Authors: de Sousa Paredes SC, Mota-Garcia F Abstract BACKGROUND: Nutritional deficiencies are common among obese individuals and constitute one of the main concerns in the bariatric field. The aim of this study was to investigate nutritional status in bariatric surgery candidates, comparing individuals with and without metabolic syndrome (MetS) and to explore possible associations between nutritional and metabolic status. METHODS: Patients accepted for gastric sleeve surgery between 2010 and 2015 were included and anthropometric and metabolic parameters were recorded before surgery. Univariate and multivariate ...
Source: Hormones - August 21, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Behavioral assessment of females with congenital adrenal hyperplasia.
CONCLUSION: Females with CAH had frequent and severe behavioral symptoms. Excess androgenization, which was in part due to suboptimal steroid therapy, was the cause of the behavioral problems. Therefore, early optimization of CAH management should be stressed to prevent psychological consequences. PMID: 32740726 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - August 4, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Improvement of anti-M üllerian hormone and oxidative stress through regular exercise in Chinese women with polycystic ovary syndrome.
CONCLUSIONS: Our findings demonstrated that 12 weeks of aerobic exercise produced beneficial effects on BMI, cardiovascular fitness, AMH, and oxidative stress in PCOS women. Favorable modification of oxidative stress might thus be an effective method for improvement of AMH in these women, which deserves further exploration in the future. PMID: 32725588 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 31, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Triple A (Allgrove) syndrome due to AAAS gene mutation with a rare association of amyotrophy.
CONCLUSION: In any young patient with AI not due to congenital adrenal hyperplasia, Allgrove syndrome should be ruled out. Though mineralocorticoid sparing pattern is classical, it can rarely be involved, as seen in the index case. Various components of the syndrome, as well as amyotrophy and other neurologic features, may present in a metachronous fashion. Hence, a high index of clinical suspicion can aid in early diagnosis and management. PMID: 32700293 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 25, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic.
CONCLUSION: Clinicians should be aware of thyroid manifestations potentially associated with COVID-19. PMID: 32676935 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 19, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Novel mutations of the LHCGR gene in two families with 46,XY DSD causing Leydig cell hypoplasia I.
CONCLUSION: Although the mutations of the LHCGR gene are distributed heterogeneously, without hotspot or recurrent mutations, about one fifth of the reported mutations worldwide have been detected in Arab patients. This is probably due to the high consanguinity rate in these populations, which increases the percentage of autosomal recessive disorders and the homozygous LHCGR gene mutations. PMID: 32666356 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Vitamin D and COVID-19.
Authors: Trovas G, Tournis S Abstract Epidemiological data report that several countries with a high prevalence of hypovitaminosis D may have increased susceptibility to complications and mortality due to COVID-19 infection. These reports, however, have limitations given that they derive from observational studies. Nevertheless, while awaiting more robust data, clinicians should treat patients with vitamin D deficiency irrespective of whether or not it has a link with respiratory infections. PMID: 32666357 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A systematic review and meta-analysis of recent studies reporting hormone levels related to thyroid gland function in migraineurs, until April 2020.
CONCLUSIONS: The results of the current study point to an association between migraine pathogenesis and changing TSH levels in comparison with those of controls. PMID: 32666358 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Iodized table salt consumption among patients with Hashimoto's thyroiditis.
Authors: Mazokopakis EE PMID: 32632886 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 9, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Graves' hyperthyroidism-related pancytopenia: a case report with literature review.
CONCLUSION: Searching in the English literature for previous studies, we identified only 30 cases worldwide to form our database. A demographic as well as clinical, laboratory, and histopathological analysis was performed. In most cases, the recovery of biochemical euthyroidism through the use of ATDs induced the resolution of pancytopenia (at laboratory and histological levels). Our review provides clinical, laboratory, and histopathological features of Graves's hyperthyroidism-related pancytopenia with a view to improving the knowledge of this rare hematological complication and assisting in the decision-making process r...
Source: Hormones - July 9, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Gender difference of association between plasma N-terminal pro-atrial natriuretic peptide and metabolic syndrome.
CONCLUSIONS: There are gender differences in the relationship between NT-proANP and MetS, while an inverse association between plasma NT-proANP and MetS in men suggests that higher levels of NT-proANP may be a protective factor for MetS. PMID: 32617886 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 5, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Correction to: Effect of selenium supplementation on antioxidant markers: a systematic review and meta-analysis of randomized controlled trials.
Authors: Hasani M, Djalalinia S, Khazdooz M, Asayesh H, Zarei M, Gorabi AM, Ansari H, Qorbani M, Heshmat R Abstract The original version of this article, published on 10 December 2019 contained a mistake. PMID: 32613535 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 4, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Reproductive health in women with type 2 diabetes mellitus.
Authors: Creţu D, Cernea S, Onea CR, Pop RM Abstract As type 2 diabetes mellitus (T2DM) reaches epidemic proportions in the developed world and the age at diagnosis decreases, more women of reproductive age are being affected. In this article, we provide a synoptic view on potential mechanisms and relevant factors underlying menstrual cycle disorders and fertility issues in women with T2DM. The article discusses the function of the hypothalamic-pituitary-ovarian (HPO) axis, the central role of the hypothalamus in the homeostasis of this system, the central modulators of the axis, and the peripheral metabolic signa...
Source: Hormones - July 4, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Correlation of serum C1q-tumour necrosis factor-related protein 5 levels with metabolic parameters and carotid intima-media thickness in newly diagnosed type 2 diabetes mellitus patients.
CONCLUSION: Serum CTRP5 levels were correlated with cardiometabolic parameters and could therefore be a promising indicator of metabolic status and a possible biomarker of insulin resistance. However, the contradictory results reported in different studies indicate the need for further research to assess the significance of CTRP5 for diagnosis and monitoring of treatment efficacy. PMID: 32594414 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - July 2, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The function of uterine UDP-glucuronosyltransferase 1A8 (UGT1A8) and UDP-glucuronosyltransferase 2B7 (UGT2B7) is involved in endometrial cancer based on estrogen metabolism regulation.
CONCLUSION: These results indicated that UGT1A8 and UGT2B7 may contribute to the estrogen signaling pathway and the pathogenesis of EC. PMID: 32592099 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - June 29, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The timing of fasting leads to different levels of food consumption and PYY3-36 in nocturnal mice.
CONCLUSIONS: These results indicate that mice exhibit distinct food consumption patterns after being presented with a fast at different times of the day. Light exposure also modulates both food consumption after a fast and levels of PYY3-36. PMID: 32572709 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - June 25, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Seven cases of parathyroid carcinoma and review of the literature.
Authors: Apaydın T, Yavuz DG Abstract Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71.4%). Median age at diagnosis was 47 years, and median follow-up duration was 60 months (IQR 29-75). Mean calcium level at diagnosis was 12.7 mg/dL (range, 11.3-13.9), and mean parathormone level was 1115 ng/L (IQR 287-1470). Two patients (28.5%) had a palpable neck mass. Coexisting brown tumor was present in three patients (42.8%), and nephrolithiasis was found in one patien...
Source: Hormones - June 25, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Efficacy of sex hormone-binding globulin on predicting metabolic syndrome in newly diagnosed and untreated patients with polycystic ovary syndrome.
Authors: Fu C, Minjie C, Weichun Z, Huihuang Y, Guishan C, Qingxia H, Xiaoping Y, Lan C, Ping W, Chujia L, Guoshu Y Abstract PURPOSE: The aims of this study were to investigate the correlation of sex hormone-binding globulin (SHBG) and the components of metabolic syndrome (MetS) and explore the ability of SHBG to predict MetS in newly diagnosed and untreated patients with polycystic ovary syndrome (PCOS). METHODS: Ninety-eight newly diagnosed and untreated patients with PCOS and 37 healthy volunteers were recruited. A receiver operating characteristic (ROC) curve was used to explore the best cutoff values of SH...
Source: Hormones - June 22, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Association between HDL-C levels and menopause: a meta-analysis.
CONCLUSION: Unlike increased LDL-C, TC, and TG levels, HDL-C levels in pre- and postmenopausal women were not different in this first meta-analysis of lipid profiles in premenopausal and postmenopausal women. Prospective studies with large populations examining HDL-C levels and functions in women with different menopausal statuses are essential in the future. TRIAL REGISTRATION NUMBER: None. PMID: 32557344 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - June 21, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Relative energy deficiency in sports (RED-S): elucidation of endocrine changes affecting the health of males and females.
Authors: Dipla K, Kraemer RR, Constantini NW, Hackney AC Abstract The purpose of this review is to present a different perspective of the relative energy deficiency syndrome, to improve understanding of associated endocrine alterations, and to highlight the need for further research in this area. The term "female athlete triad" was coined over 25 years ago to describe three interrelated components: disordered eating, menstrual dysfunction, and low bone mass. The syndrome's etiology is attributed to energy intake deficiency relative to energy expenditure required for health, function, and daily living...
Source: Hormones - June 21, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Estrogen and bones after menopause: a reappraisal of data and future perspectives.
Authors: Anagnostis P, Bosdou JK, Vaitsi K, Goulis DG, Lambrinoudaki I Abstract Menopausal hormone therapy (MHT) is effective in preventing menopause-related bone loss and decreasing vertebral, non-vertebral and hip fracture risk. MHT contains estrogens that exert both antiosteoclastic and osteoanabolic effects. These effects are dose-dependent, as even ultra-low doses preserve or increase bone mineral density. The transdermal route of administration is effective on cancellous and cortical bone, although fracture data are still lacking. Hormone replacement therapy is the treatment of choice to preserve skeletal hea...
Source: Hormones - June 12, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Consumers' attitude toward dietary supplements and functional food: a prospective survey in a Greek population sample.
CONCLUSION: Our findings provide valuable data concerning active Greek consumers' attitudes toward these relative new products, which could be extended to other Mediterranean and South European populations. PMID: 32504223 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - June 8, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Type 2 diabetes mellitus management in patients with chronic kidney disease: an update.
Authors: Kleinaki Z, Kapnisi S, Theodorelou-Charitou SA, Nikas IP, Paschou SA Abstract Diabetes mellitus (DM) is a chronic multisystem disease. Diabetic nephropathy (DN) is one of its significant microvascular complications, associated with increased morbidity and mortality. The aim of this article is to review the literature regarding the latest advances in the management of type 2 DM (T2DM) in patients with chronic kidney disease (CKD). We initially refer to the screening guidelines, the diagnostic tests used, the need for novel biomarkers in DN, the recent advances in high-risk patient identification, the recomm...
Source: Hormones - June 6, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Onset of Marine-Lenhart syndrome and Graves' ophthalmopathy in a female patient treated with alemtuzumab for multiple sclerosis.
CONCLUSION: We present a case of Graves' disease with active, moderate-to-severe Graves' ophthalmopathy in a patient with pre-existing AFTN presenting with a coexisting, rare case of Marine-Lenhart syndrome associated with immune reconstitution after alemtuzumab treatment. PMID: 32500462 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - June 6, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Relationship of thyroid dysfunction with cardiovascular diseases: updated review on heart failure progression.
Authors: Abdel-Moneim A, Gaber AM, Gouda S, Osama A, Othman SI, Allam G Abstract Heart disease remains the leading cause of death globally. Heart failure (HF) is a clinical syndrome that results from impairment of the ability of the ventricle to fill with or eject blood. Over the past two decades, accumulated evidence has revealed the contribution of thyroid hormones to cardiovascular (CV) events, exerting their action through genomic and non-genomic pathways within the cardiomyocytes. The pivotal role of thyroid hormones in maintaining cardiac homeostasis has been observed in previous investigations which suggest ...
Source: Hormones - June 5, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Psycho-neuro-endocrino-immunologic issues in multiple sclerosis: a critical review of clinical and therapeutic implications.
Authors: Anagnostouli M, Markoglou N, Chrousos G Abstract Multiple sclerosis (MS) is a multifactorial, chronic, immune-mediated, and neurodegenerative disease, having a well-known hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Several hormones have a great impact in the immune dysregulation, psychology, and cognitive status of patients with MS, as also in the fertility and response to treatment. In this comprehensive review, as an introduction, we mention basic data concerning MS: epidemiology, genetics, immunogenetics, epigenetics, pathophysiology, and neuroimmunology. Hormonal components of the disease ca...
Source: Hormones - June 5, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Sexual dysfunction in polycystic ovary syndrome: a systematic review and meta-analysis.
Authors: Loh HH, Yee A, Loh HS, Kanagasundram S, Francis B, Lim LL Abstract PURPOSE: Polycystic ovarian syndrome (PCOS) is a common disorder characterized by clinical or biochemical hyperandrogenism and ovulary dysfunction. Female sexual dysfunction (FSD) adversely affects quality of life and interpersonal relationships. We aimed to compare the prevalence of FSD in women with and without PCOS. METHODS: We pooled data from 28 observational studies involving 6256 women. Apart from the total prevalence of FSD, subgroup analyses based on different PCOS diagnostic criteria and obesity status (body mass index [BMI]&t...
Source: Hormones - May 30, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Insulin resistance, androgens, and lipids are gradually improved in an age-dependent manner in lean women with polycystic ovary syndrome: insights from a large Caucasian cohort.
Authors: Livadas S, Macut D, Bothou C, Kuliczkowska-Płaksej J, Vryonidou A, Bjekic-Macut J, Mouslech Z, Milewicz A, Panidis D Abstract PURPOSE: Polycystic ovary syndrome (PCOS), considered a lifelong condition, manifests mainly as a cluster of hyperandrogenic symptoms during the early reproductive years, with the affected woman gradually developing an adverse cardiometabolic profile over the years. However, some data point to the possibility of differences in the evolution of PCOS according to a woman's weight. The aim of the present study was to evaluate the metabolic and hormonal profiles of women with PCOS over...
Source: Hormones - May 27, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical practice guidelines on diabetes mellitus and pregnancy: ΙI. Gestational diabetes mellitus.
Clinical practice guidelines on diabetes mellitus and pregnancy: ΙI. Gestational diabetes mellitus. Hormones (Athens). 2020 May 25;: Authors: Anastasiou E, Farmakidis G, Gerede A, Goulis DG, Koukkou E, Kourtis A, Mamopoulos A, Papadimitriou K, Papadopoulos V, Stefos T Abstract Gestational diabetes mellitus (GDM) is the most common metabolic disease of pregnancy and is associated with several perinatal complications. GDM is defined as diabetes diagnosed in the second or third trimester of pregnancy that was not clearly overt diabetes prior to gestation. In Europe, in 2016, the prevalence of GDM was...
Source: Hormones - May 27, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Is there an association between serum 25(OH)D3 and mental well-being in patients with type 2 diabetes? Results from a cohort study in primary care.
CONCLUSION: We found an inverse association between 25(OH)D3 and mental health in patients with T2D at baseline. We found no association between 25(OH)D3 and vitality after adjustment. Future studies are needed to determine the association between vitamin D and mental well-being in patients with T2D. PMID: 32440752 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - May 23, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical practice guidelines on diabetes mellitus and pregnancy: Ι. Pre-existing type 1 and type 2 diabetes mellitus.
Clinical practice guidelines on diabetes mellitus and pregnancy: Ι. Pre-existing type 1 and type 2 diabetes mellitus. Hormones (Athens). 2020 May 15;: Authors: Anastasiou E, Farmakidis G, Gerede A, Goulis DG, Koukkou E, Kourtis A, Mamopoulos A, Papadimitriou K, Papadopoulos V, Stefos T Abstract Women with type 1 (T1DM) or type 2 diabetes (T2DM) diagnosed prior to pregnancy are classified as having pre-existing diabetes mellitus (DM). The prevalence of hyperglycemia in pregnancy has been estimated at 17% globally and 5.4% in Europe, differences existing among racial and ethnic groups, following the...
Source: Hormones - May 19, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

A closer look at NIFTP.
Authors: Dhanushika T, Priyani AAH, Ranaweera MEM, Ranaweera GG, de Silva MVC, Dassanayake RS Abstract Despite the rise in the incidence of papillary thyroid carcinoma (PTC) during the last 30 years, the mortality rate due to PTC has remained static. One reason for this phenomenon is the indolent nature of some of the tumors that are diagnosed as PTC. A subgroup of tumors, which often exhibited such indolent behavior, was encapsulated/well-circumscribed follicular lesions that showed PTC nuclear features. Despite their indolent behavior, these tumors were managed as was any other PTC, often with total thyroide...
Source: Hormones - May 19, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Large adrenal ganglioneuroma: A rare entity with atypical radiological characteristics.
Authors: Boutzios G, Papaoiconomou E, Karatza E, Dimitroulis D PMID: 32415649 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - May 19, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Prevention strategies for type 1 diabetes: a story of promising efforts and unmet expectations.
Authors: Kanta A, Lyka E, Koufakis T, Zebekakis P, Kotsa K Abstract A number of studies have investigated primary and secondary prevention strategies for type 1 diabetes (T1D), since early interventions might improve long-term outcomes through the amelioration of immune processes and the preservation of beta-cell mass. Primary prevention trials focus on genetically at-risk individuals prior to the appearance of autoimmunity, whereas secondary prevention trials aim to halt the progression of complete beta-cell destruction in subjects with established islet autoimmunity (IA). Different approaches have been tested so ...
Source: Hormones - May 19, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The use of computed tomography as a first-line imaging modality in patients with primary hyperparathyroidism.
Authors: de Jong MC, Jamal K, Morley S, Beale T, Chung T, Jawad S, Hurel S, Simpson H, Srirangalingam U, Baldeweg SE, Rozalén García V, Otero S, Shawky M, Abdel-Aziz TE, Kurzawinski TR Abstract BACKGROUND: The success of minimally invasive parathyroidectomy (MIP) relies on accurate localization of the abnormal parathyroid glands. Concordant findings on ultrasound (US) and 99mTc-scintigraphy (sestamibi) are currently considered the 'gold standard'. Computed tomography (CT) has also recently been used in preoperative planning. We sought to assess the accuracy of CT for localization of abnormal parathyro...
Source: Hormones - May 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

AMY1 diploid copy number among end-stage renal disease patients.
CONCLUSIONS: AMY1-odd diploid CN appears to be associated with selected adiposity variables among hemodialysis patients. However, more research is needed to verify this finding in this population with known increased cardiovascular risk. PMID: 32405930 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - May 16, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Thyroid hormones and the mechanisms of adaptation to cold.
Authors: Tsibulnikov S, Maslov L, Voronkov N, Oeltgen P Abstract The thyroid gland plays a crucial role in the regulation of metabolism, oxygen consumption, and the release of energy in the form of heat to maintain the body. Even at rest, these processes are sensitive to changes in thyroid function. This means that along with the adrenergic system, thyroid function determines the organism's ability to adapt to cold. Cold adaptation causes deiodination of thyroxine (T4) and thus promotes an increase in blood triiodothyronine (T3) levels in humans and animals. Triiodothyronine is an inductor of iodothyronine deiodina...
Source: Hormones - May 15, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Adrenal-sparing surgery: current concepts on a theme from the past.
Discussion of these controversial topics represents an attempt to define the role of partial adrenalectomy in modern adrenal surgery. PMID: 32388629 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - May 12, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical features and therapeutic outcomes of patients with acromegaly in Saudi Arabia: a retrospective analysis.
CONCLUSIONS: Our findings highlight the need for a national acromegaly registry to enable early identification, evaluation, and selection of the best therapeutic approaches to improve the outcome and remission rate of the disease. PMID: 32388630 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - May 12, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Trends in the epidemiology of thyroid diseases in Bulgaria since the year 2000-a review of the literature.
Authors: Boyanov MA Abstract This review attempts to summarize data on the prevalence of thyroid pathology in the Bulgarian population over a period of 20 years. Thyroid dysfunction was studied in two population-based studies (2006 and 2012). In the first, hypothyroidism was found in 6.3% and hyperthyroidism in 3.7% of the participants. The second study found overt and subclinical hypothyroidism in 3.2% and 4.5%, respectively, of females, and in 1.1% and 2% of males. TPOAb levels were elevated in 23% of females and in 9.6% of males. Nodules were found using ultrasound (US) in 23.4% of the participants in the 2...
Source: Hormones - April 26, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

The regulation of serum resistin levels in metabolically healthy and unhealthy obese individuals.
CONCLUSION: Circulating resistin was higher in MUO compared with MHO. The increased secretion of resistin by the greater number of neutrophils in the former may have contributed to this regulation. PMID: 32328905 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - April 26, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Langerhans cell histiocytosis of the thyroid together with papillary thyroid carcinoma.
Authors: Ozisik H, Yurekli BS, Demir D, Ertan Y, Simsir IY, Ozdemir M, Erdogan M, Cetinkalp S, Ozgen G, Saygili F PMID: 32314308 [PubMed - as supplied by publisher] (Source: Hormones)
Source: Hormones - April 23, 2020 Category: Endocrinology Tags: Hormones (Athens) Source Type: research