Intraplacental Hepatic Heterotopia.
Conclusion: Intraplacental hepatic heterotopia is associated with premature labor. Distinguishing this lesion from maternal and fetal malignancies with similar histopathological presentation has important clinical implications in patient care. PMID: 33399014 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - January 7, 2021 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Vertical Transmission of SARS-CoV-2 from COVID-19 Infected Pregnant Women: A Review on Intrauterine Transmission.
CONCLUSION: There is probable intrauterine transmission of SARS-CoV-2. Few adverse fetal outcomes are associated with COVID-19. PMID: 33356716 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 29, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Localized Placental Mesenchymal Dysplasia in Monochorionic Diamniotic Twin Placenta with Beckwith-Wiedemann Syndrome.
Conclusion: Localized placental mesenchymal dysplasia can occur in monochorionic diamniotic twin placenta with Beckwith-Wiedemann syndrome. Fetal affects may be asymmetric. PMD can be associated with mosaicism monosomy of chromosome 11. PMID: 33356737 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 29, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Maternal and Placental Zinc and Copper Status in Intra-Uterine Growth Restriction.
Authors: Yücel Çelik Ö, Akdas S, Yucel A, Kesikli B, Yazihan N, Uygur D Abstract BACKGROUND AND AIM: Zinc and copper are essential trace elements for cell growth and proliferation. Their deficiency may contribute to intrauterine growth restriction (IUGR). We aimed to determine the zinc and copper status of maternal serum and placenta samples of pregnant women with fetal IUGR and age-matched pregnant women without IUGR. METHOD: Serum and placenta samples obtained from 37 IUGR and 21 healthy pregnant women were analyzed at delivery. RESULTS: Placenta zinc concentrations and placenta zinc/copp...
Source: Fetal and Pediatric Pathology - December 16, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Congenital Sacrococcygeal Neuroblastoma: A Report of Two Cases with Summary of Prior Published Cases.
CONCLUSION: Congenital presacral neuroblastoma should be differentiated from teratomatous lesions, and in general have a good prognosis. PMID: 33307929 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 16, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Annular Indentation of the Ventricles in a Stillborn: A Case Report and Literature Review.
Conclusion: Circumferential indentation of ventricles is distinguished from constrictive pericarditis and other myocardial defects as histologically the three layers of endocardium, myocardium, and pericardium are intact. PMID: 33305650 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 13, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

The Value of BRAF VE1 Immunoexpression in Pediatric Langerhans Cell Histiocytosis.
Conclusions: The proportion of BRAF V600E mutational status was relatively high and related to high-risk LCH. Molecular assays for BRAF mutation detection are preferred in LCH lesions. VE1 is not ready as an alternative option for LCH BRAF testing. PMID: 33295826 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 10, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Combined Placental Maternal Floor Infarction and Cytomegalovirus Placentitis: A Case Report.
Conclusion: VUE is considered to be a maternal anti-fetal immune reaction resembling allograft rejection. We postulate that the viral infection in our case may have triggered this immune response, given that CMV antigens are known to cross react with some human antigens, in particular HLA. The subsequent trophoblastic cell damage could then lead to MFI/MFPD. PMID: 33295828 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 10, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Gestational Outcomes of Pregnant Women with Unilateral Congenital Renal Agenesis.
Authors: Fadiloglu E, Zaim OC, Cagan M, Unal C, Beksac MS Abstract OBJECTIVE: We evaluated if there were more adverse gestational outcomes of pregnant women with unilateral congenital renal agenesis (UCRA). Study design: This single center retrospective case-control study compared maternal complications and neonatal outcomes from 25 women with UCRA to the outcomes of 125 women with two kidneys. Results: UCRA women had lower gestational weeks at birth and higher rates of preterm delivery (p = 0.004 and
Source: Fetal and Pediatric Pathology - December 10, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Detection of Parental Contribution to Molar Genome Leads to Diagnosis of Recurrent Hydatidiform Mole in a Family with NLRP7 Variants.
Conclusion: The genotype study should be obtained for patients of CHM, even in their first pregnancy, followed by genetic screening for maternal-effect variants in those with biparental moles. This strategy will identify patients in their first pregnancy with HM that have a decreased chance for a normal pregnancy, to allow genetic counseling, perhaps utilizing a donor egg. PMID: 33252287 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 3, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

'Hybrid' Bronchopulmonary Malformation - Lobar Emphysema and Extra Lobar Sequestration.
Discussion/conclusion: The observations suggest that BPS and ILE may be interim entities in a continuum of abnormal embryogenesis. Such a hybrid malformation has not been hitherto reported. PMID: 33252288 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 3, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Bladder Exstrophy Polyp: An Uncommon Entity in Surgical Pathology.
Conclusion: Bladder exstrophy polyp is a distinct pathologic entity with a combination of various nonspecific findings. Pathologists should be cognizant of the histologic spectrum of this uncommon entity. PMID: 33252291 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 3, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Papillary Endothelial Hyperplasia of Scalp with Bone Erosion: A Case Report with Review of Literature.
Conclusion: Scalp PEH with skull bone defect can affect the pediatric age group. Bone erosion is not stage dependent; it can occur in the early stages. PMID: 33252296 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 3, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Value of Placental Examination in the Diagnostic Evaluation of Stillbirth.
Conclusion: Placental lesions were the main causes of stillbirth and were predominantly of vascular type including chronic villous hypoxia-ischemia and funicular anomalies. PMID: 33263451 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - December 3, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Extraskeletal Ewing's Sarcoma with CD7 Positivity and T-cell Receptor/Immunoglobulin Rearrangement Masquerading as T-lymphoblastic Lymphoma.
Conclusion: In addition to typical genetic alterations, Ewing sarcoma can also express CD7 and TCR/Ig rearrangement, which are not limited to lymphoma. PMID: 33213248 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 22, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Benchmark Examination of Blood Amino Acids Patterns in Phenylketonuria Neonates and Young Children on Phenylalanine-Restricted Dietary Treatment.
Conclusions: Blood amino acid homeostasis is disrupted in phenylketonuria. Although dietary intervention adjusts amino acid homeostasis in the direction of a healthy equilibrium, complete restoration is not achieved. PMID: 33198547 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 19, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Possible Role of TGF- β1, MMP-2, E-CAD, β-Catenin and Antioxidants in Pathogenesis of Placenta Accreta.
Conclusion: These findings suggest that loss of cell-cell adhesion and increased antioxidants level may have a role in PA. PMID: 33172328 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 13, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Giant Anal Fibroepithelial Polyp in a Healthy Teenage Boy: A Case Report and Literature Review.
Conclusions: While literature describes the spectrum of pathology possible in such lesions, often consisting of a mixture of stromal and epithelial components, dilated lymphatics are less common. This giant anal fibroepithelial polyp characterized by edematous stroma and numerous dilated lymphatics is consistent with lymphangioma. To our knowledge, this presentation is novel in this age group with no underlying risk factors. PMID: 33164595 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 12, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Cutaneous B-Cell Pseudolymphoma (Lymphocytoma Cutis) of the Earlobe: A Poorly Recognized Complication of Ear Piercing in Children.
Conclusion: Our report expands the clinico-pathological spectrum of CPL associated with ear piercing by documenting its occurrence in children. PMID: 33150803 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - November 6, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Idiopathic Pericardial Ossification Causing Chronic Constrictive Pericarditis.
CONCLUSION: Idiopathic pericardial ossification can cause CCP in pediatric patients. PMID: 33103518 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 27, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Large Subchorionic Cyst Located at Umbilical Cord Insertion with Vascular Displacing and Intracystic Hemorrhage/Hematoma: A Case Report.
Conclusion: Recognition of large subchorionic cysts close to or at the PCIS in a growth restricted fetus with subsequent expedited delivery may avoid a fatal event. PMID: 33103529 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 27, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Clinical Features, Autoantibodies, and Outcome of Neonatal Lupus Erythematosus.
Conclusions: Anti-SSA and anti-SSB are associated with cardiac and cutaneous manifestations in NLE. Most children with NLE have excellent outcomes with symptom resolution by one year. Complete congenital heart block may persist. PMID: 33103534 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 27, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Infantile Inflammatory Myofibroblastic Tumor of Spleen.
Conclusions: IMT can arise in an infant spleen. PMID: 33095087 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 24, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Decrease in Hospitalizations and Increase in Deaths during the Covid-19 Epidemic in a Pediatric Hospital, Yaounde-Cameroon and Prediction for the Coming Months.
Conclusion: The COVID-19 pandemic was marked by drop in hospitalizations and paradoxically, an increase in child mortality. These deaths were probably due not to SARS-Cov-2 infection, but rather due to the usual illnesses whose management was delayed, a probable consequence of the confinement. PMID: 33078968 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 22, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Evaluation of Fetal Serum Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Fetal Distress.
Conclusion: The thiol-disulfide homeostasis shifts toward the oxidant direction during the FD pathogenesis and the increased IMA levels may be the best indicator of an underlying non-acute ischemic condition. PMID: 33063566 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 20, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Tricuspid Valve Dysplasia at Fetal Autopsy.
Conclusion: The difficulties in differentiating Ebstein anomaly from tricuspid valve dysplasia due to inherent limitations in fetal imaging can be resolved by fetal autopsy. Valvular dysplasia will not have apical displacement of the valve leaflets. PMID: 33063582 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 20, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Differential Activation of Immune Effector Processes in Mature Compared to Immature Sacrococcygeal Teratomas.
Conclusion: The broad repertoire of histological elements in SCTs reflects differences in transcriptional regulation rather than differences in gene copy numbers. A paucity of immune response in immature SCTs may be a factor contributing to their uninhibited growth. PMID: 33063585 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 20, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women.
Conclusion: Placentas from SARS-CoV-2-positive women do not demonstrate a specific pathological pattern. Pregnancy complicated with COVID-19 during the 3rd trimester does not have a demonstrable effect on placental structure and pathology. PMID: 33040615 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 14, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Pseudo-Roberts Syndrome: An Entity or Not?
Conclusion: Given the various skeletal anomalies found on autopsy and imaging evaluations, at least phenotypically, our case appeared to conform into Roberts syndrome spectrum. Since the infant did not have the mutation associated with this disorder, this infant could be labeled as the first report of a pseudo-Roberts syndrome because many of his phenotypic anomalies are characteristic of Roberts syndrome in absence of the ESCO2 gene mutation. PMID: 33026893 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 9, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Effect of the Prenatal Exposure of Khat on the Skeleton of Developing Rabbit Embryo: Morphometric and Gross Anatomical Study.
Conclusion: These findings support the teratogenic effect of the khat on the developing rabbit fetus. PMID: 33026921 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - October 9, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Choroid Plexus Carcinoma with Hyaline Globules: An Uncommon Histological Finding.
Conclusion: CPC can occasionally show AFP immune-positive hyaline globules. PMID: 32969735 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - September 26, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

A Novel Method for Observing Tumor Margin in Hepatoblastoma Based on Microstructure 3D Reconstruction.
Conclusions: Microstructure 3 D reconstruction is feasible for observing the pathological structure of the HB tumor margin. PMID: 32969743 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - September 26, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

FoxM1 Regulates Proliferation and Apoptosis of Human Neuroblastoma Cell through PI3K/AKT Pathway.
Conclusion: FoxM1 knockdown inhibited NB cell proliferation and induced apoptosis through inhibiting activation of PI3K and AKT. PMID: 32901528 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - September 11, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Monochorionic Twin Discordance for Horseshoe Lung and Tricuspid Atresia.
Conclusion: The discordance of anomalies in this monochorionic twin suggests that a postzygotic mutation, epigenetic change, or environmental factors may be responsible for these malformations. PMID: 32886556 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - September 6, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

The Giant Infantile Fibrosarcoma of Fetal Oropharynx and Anterior Neck.
Conclusion: IFS may arise as early as 24 weeks of gestation. In this case, an EXIT procedure allowed postpartum diagnosis with subsequent treatment. PMID: 32835576 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 25, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

First Trimester Prenatal Diagnosis of a Conotruncal Anomaly Using Spatiotemporal Image Correlation Imaging Confirmed by Conventional Autopsy.
Conclusion: Four-dimensional STIC imaging provides incremental benefits in evaluation of fetal cardiac anomalies, and confirmation by autopsy findings allows further refinement of the diagnosis. PMID: 32815432 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 22, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Penile Agenesis with Urethrorectal Fistula and Vesicoureteral Reflux.
Conclusion: Penile agenesis is a complex genital abnormality. It can be associated with urinary malformations that should be systematically investigated. PMID: 32787699 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 15, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Rectal Inflammatory Myoglandular Polyp with Osseous Metaplasia in a Child.
Conclusion: Benign osseous metaplasia can be found in IMGP. PMID: 32772867 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 14, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Large Congenital Epulis: A Neonatal Tumour with Striking Appearance, but Simple Management.
Conclusion: A large congenital epulis, though worrisome to parents, can be satisfactorily managed by surgical excision and has a good prognosis. PMID: 32779496 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - August 14, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Fetal & Pediatric Pathology.
Conclusions: Although the clinical significance is unclear, this second case of CC with septate gallbladder and ectopic pancreas highlights the embryologic association of these abnormalities. PMID: 32723208 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 31, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Letter Regarding "Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)".
Letter Regarding "Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)". Fetal Pediatr Pathol. 2020 Jul 28;:1-3 Authors: Bradford T PMID: 32720537 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 29, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Tunical Gliomatosis: An Uncommon Histological Entity.
Conclusion: Tunica vaginalis gliomatosis can occur in the setting of a retroperitoneal extragonadal congenital immature teratoma. PMID: 32720553 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 29, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Utility of Chromosomal Microarray in Children with Unexplained Developmental Delay/Intellectual Disability.
Conclusions: In our study, 20.9% of children with GDD/ID showed pCNVs on CMA. Cardiac defect alongside GDD/ID, emerged as the single strongest phenotype associated with pCNVs. CMA also provided vital information in previously karyotyped patients. PMID: 32701375 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 25, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Hepatic and Adrenocortical Choristomas in the Placenta.
Authors: Schaumann N, Hussein K Abstract BACKGROUND: Hepatic and adrenocortical choristomas are unusual findings in the placenta. This meta-analysis includes our own case report and 23 previously reported cases. We searched for patterns of associated placental, fetal and maternal aberrations in order to determine whether these choristomas are clinically relevant. Case report: In our case, abortion was induced due to fetal central nervous system and renal malformations. In the placenta a hepatic choristoma (
Source: Fetal and Pediatric Pathology - July 23, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

The Effect of Antenatal Steroid Therapy on Early Inflammation Markers and Leukocyte Counts in Premature Infants.
CONCLUSION: Consistent with the literature data, AST was associated with reduced neutrophil count but did not affect the other inflammatory markers studied. PMID: 32677483 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 19, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Association of +1923C   >  T, -1112C  >  T and +2044A  >  G Polymorphisms in IL-13 Gene with Susceptibility to Pediatric Asthma: A Systematic Review and Meta-Analysis.
Conclusions: Our pooled data indicated that IL-13 + 1923 C > T, -1112 C > T and +2044 A > G polymorphisms were correlated with risk of pediatric asthma. PMID: 32643534 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 11, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Pediatric Hypersensitivity Pneumonitis: Clinicopathologic Characteristics of Two Cases with Fungal Triggers.
Conclusions: A diagnosis of HP should be considered in pediatric lung biopsies with granulomatous interstitial and peribronchial inflammation, if infectious etiologies are excluded. Integration of clinical, radiological, and laboratory findings can facilitate a timely diagnosis. PMID: 32619123 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 5, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Coexistence of Three Different Mutations in a Male Infant: neurofibromatosis Type 1, Progressive Familial Intrahepatic Cholestasis Type 2 and LPIN3.
CONCLUSION: Our case illustrates the complexities of multiple genetic mutations in a child. PMID: 32597698 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 2, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Sex-Cord Tumor with Annular Tubules with Unusual Morphology in an Infant with Peutz-Jeghers Syndrome.
Conclusion: SCTAT can occur as young as six months of age in PJS, and may show histologic overlap with lipid-rich Sertoli cell tumors. PMID: 32609034 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 2, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research

Mosaic Trisomy 12: Prenatal Diagnosis at Amniocentesis and Molecular Genetic Analysis on Fetal Tissues.
Conclusion: We report a new case of mosaic trisomy 12 with non-lethal morphological findings not previously described. Although prenatal ultrasound may be negative, genetic counseling should consider minor abnormalities and widespread presence of trisomic cell lines in various internal organs. PMID: 32609035 [PubMed - as supplied by publisher] (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - July 2, 2020 Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research