Up-regulation of lncRNA WT1-AS ameliorates A β-stimulated neuronal injury through modulation of miR-186-5p/CCND2 axis in Alzheimer's disease
Cell Mol Biol (Noisy-le-grand). 2024 Jan 31;70(1):200-206. doi: 10.14715/cmb/2024.70.1.27.ABSTRACTAs a common neurodegenerative disorder, Alzheimer's disease (AD) seriously threatens human life. Long non-coding RNAs (lncRNAs) exhibit essential functions in AD development. Nevertheless, the detailed effects and possible mechanisms of lncRNA Wilms tumor 1 Antisense RNA (WT1-AS) in AD are largely unknown. In our studies, a total of 30 serum samples from AD patients were collected, and WT1-AS expressions were detected through qRT-PCR analysis. Additionally, an in vitro AD model was constructed by treating Aβ1-42 in human neur...
Source: Cellular and Molecular Biology - February 19, 2024 Category: Molecular Biology Authors: Yun Tang Xiaojiu Zhang Shihui Wang Lu Liu Qing Wang Yufeng Liu Yadong Yu Qijin Zhai Source Type: research
Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury
Eur J Pharm Biopharm. 2024 Feb 15:114218. doi: 10.1016/j.ejpb.2024.114218. Online ahead of print.ABSTRACTMyocardial ischemia/reperfusion (MI/R) injury is the primary cause of postischemicheartfailure. The increased expression of Thioredoxin-interacting protein (TXNIP) has been implicated in MI/R injury, although the detailed mechanism remains incompletely understood. In the present study, we observed the up-regulation of the m6A mRNA methylation complex component Wilms' tumor 1-associating protein (WTAP) in MI/R mice, which led to the m6A modification of TXNIP mRNA and an increase in mRNA abundance. Knock-down of WTAP resu...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 17, 2024 Category: Drugs & Pharmacology Authors: Tao Yin Ning Wang Fang Jia Yuchao Wu Lei Gao Jing Zhang Rongrong Hou Source Type: research
Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury
Eur J Pharm Biopharm. 2024 Feb 15:114218. doi: 10.1016/j.ejpb.2024.114218. Online ahead of print.ABSTRACTMyocardial ischemia/reperfusion (MI/R) injury is the primary cause of postischemicheartfailure. The increased expression of Thioredoxin-interacting protein (TXNIP) has been implicated in MI/R injury, although the detailed mechanism remains incompletely understood. In the present study, we observed the up-regulation of the m6A mRNA methylation complex component Wilms' tumor 1-associating protein (WTAP) in MI/R mice, which led to the m6A modification of TXNIP mRNA and an increase in mRNA abundance. Knock-down of WTAP resu...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 17, 2024 Category: Drugs & Pharmacology Authors: Tao Yin Ning Wang Fang Jia Yuchao Wu Lei Gao Jing Zhang Rongrong Hou Source Type: research
Radiomics in differential diagnosis of Wilms tumor and neuroblastoma with adrenal location in children
ConclusionIn conclusion, the CT-based clinic-radiologic-radiomics combined model could noninvasively predict WT or NB preoperatively. Notably, that model correctly predicted two patients, which none of the radiologists could correctly predict. This model may serve as a noninvasive preoperative predictor of NB/WT differentiation in CT, which should be further validated in large prospective models.Clinical relevance statementCT-based clinic-radiologic-radiomics combined model could noninvasively predict Wilms tumor or neuroblastoma preoperatively.Key Points•CT radiomics features can predict Wilms tumor or neuroblastoma fro...
Source: European Radiology - February 5, 2024 Category: Radiology Source Type: research
Impact of Wilms Tumor (WT1) Mutation on Relapse and Overall Survival in Acute Myeloid Leukemia Patients Following Allogenic Stem Cell Transplantation
Wilms tumor mutations (WT)-1 are associated with inferior survival in acute myeloid leukemia (AML); but not considered a high-risk genetic category in the European LeukemiaNet (ELN) guidelines. We compared post-allogeneic stem cell transplant (alloSCT) outcomes of WT1mut AML patients with a known poor prognostic category – TP53mut AML. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Vedavyas Gannamani, Anmol Baranwal, Kimberly J. Langer, Mohamed A. Kharfan-Dabaja, Ernesto Ayala, Vivek Roy, James Foran, Hemant Murthy, Madiha Iqbal, Jeanne Palmer, Lisa Z Sproat, Saurabh Chhabra, Nandita Khera, Mehrdad Hefazi, Abhishek Mangaonkar, Mark Tags: 138 Source Type: research
Mechanism of LncRNA FTX regulates nephroblastoma progression through MiR-215-5p/PI3K/AKT axis
Nephroblastoma, also more commonly known as Wilms tumor (WT), is a common childhood malignancy that connects tumorigenesis and organ development in the kidney. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - January 27, 2024 Category: Urology & Nephrology Authors: Li Wang, Qin Huang, Hui Li, Haisha Li, Xiangyun Wang, Xin Tan Source Type: research
Differentiation Potential of Hypodifferentiated Subsets of Nephrogenic Rests and Its Relationship to Prognosis in Wilms Tumor
Conclusions These findings may inform oncogenesis of WT and interventions directed toward poor prognosis in WT children of anaplastic histology or relapse.PMID:38217324 | DOI:10.1080/15513815.2024.2303081 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - January 13, 2024 Category: Pathology Authors: Maolin Liu Jiandong Lu Chengjun Yu Jie Zhao Ling Wang Yang Hu Long Chen Rong Han Yan Liu Miao Sun Guanghui Wei Shengde Wu Source Type: research
Downregulation of Wtap causes dilated cardiomyopathy and heart failure
In this study, we identified Wilms' tumor 1-associating protein (WTAP, a key regulatory protein of the m6A RNA methyltransferase complex) as a key regulator of heart function and cardiac diseases. WTAP is associated with heart development, and its expression is downregulated in both human and mice with heart failure. Cardiomyocyte-specific knockout of Wtap (Wtap-CKO) induces dilated cardiomyopathy, heart failure and neonatal death. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - January 13, 2024 Category: Cytology Authors: Lei Shi, Xinzhi Li, Meiwei Zhang, Cong Qin, Zhiguo Zhang, Zheng Chen Source Type: research
