Wilms' tumor gene 1 in hematological malignancies: friend or foe?
Hematology. 2023 Dec;28(1):2254557. doi: 10.1080/16078454.2023.2254557.ABSTRACTWilms' tumor gene 1 (WT1) is a transcription and post-translational factor that has a crucial role in the biological and pathological processes of several human malignancies. For hematological malignancies, WT1 overexpression or mutation has been found in leukemia and myelodysplastic syndrome. About 70-90% of acute myeloid leukemia patients showed WT1 overexpression, and 6-15% of patients carried WT1 mutations. WT1 has been widely regarded as a marker for monitoring minimal residual disease in acute myeloid leukemia. Many researchers were intere...
Source: Hematology - September 5, 2023 Category: Hematology Authors: Jie Wu Hui Yan Chunli Xiang Source Type: research
RNA N6 ‑methyladenosine methyltransferase WTAP promotes the differentiation of endothelial progenitor cells
In conclusion, the present study highlighted the involvement of m6A in regulating EPC differentiation, with WTAP acting as a promoter of EPC differentiation.PMID:37602313 | PMC:PMC10433437 | DOI:10.3892/etm.2023.12119 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 21, 2023 Category: General Medicine Authors: Longyun Wu Lili Niu Zhou Yang Qiaoyun Xia Jingyuan Xu Xiaolan Lu Source Type: research
