The efficacy and adverse events of venetoclax in combination with hypomethylating agents treatment for patients with acute myeloid leukemia and myelodysplastic syndrome: a systematic review and meta-analysis.
CONCLUSIONS: The addition of VEN to HMAs may provide significant clinical benefit for AML/MDS patients, where response rates are better in MDS and ND-AML than in R/R-AML, but attention should be paid to the possible increased risk of febrile neutropenia. PMID: 33191860 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 18, 2020 Category: Hematology Tags: Hematology Source Type: research

Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF- κB signal pathway.
CONCLUSION: PLD1 inhibition can remarkably exert antitumor effects with bortezomib on MM, which is a novel potentially targeting therapeutic agent, especially for drug-resistant MM patients. PMID: 33191863 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 18, 2020 Category: Hematology Tags: Hematology Source Type: research

Diagnostic, prognostic and predictive values of miR-100 and miR-210 in pediatric acute lymphoblastic Leukemia.
CONCLUSION: : miR-100 and miR-210 could be used as potential diagnostic markers for pediatric ALL. miR-100 is a useful prognostic and predictive biomarker for childhood ALL. PMID: 33191875 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 18, 2020 Category: Hematology Tags: Hematology Source Type: research

A novel β-thalassemia variant at HBB:c.14delC (Codon 4, -C) identified via next-generation sequencing.
CONCLUSIONS: We identified a novel frameshift variant of β-thal. NGS has the potential for identifying rare and novel thalassemia variants and broadening the spectrum of thalassemia screening and thus may contribute to effective prevention of thalassemia. PMID: 33191878 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 18, 2020 Category: Hematology Tags: Hematology Source Type: research

Malignancy-associated hemophagocytic lymphohistiocytosis in children: a 10-year experience of a single pediatric hematology center.
Conclusions: The M-HLH children with EBV infection are more likely to have prolonged APTT and more hemophagocytosis in BM. The M-HLH children had a poor prognosis, especially those with prolonged APTT. PMID: 33161882 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 11, 2020 Category: Hematology Tags: Hematology Source Type: research

Etoposide combined with ruxolitinib for refractory hemophagocytic lymphohistiocytosis during pregnancy: a case report and literature review.
In conclusion, this study highlights the challenges and difficulties in the diagnosis and management of patients with HLH during pregnancy. Moreover, this is the first case report of etoposide combined with ruxolitinib in the treatment of patients with refractory secondary HLH during pregnancy. PMID: 33138732 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 5, 2020 Category: Hematology Tags: Hematology Source Type: research

Hematologic predictors of mortality in hospitalized patients with COVID-19: a comparative study.
Authors: Mousavi SA, Rad S, Rostami T, Rostami M, Mousavi SA, Mirhoseini SA, Kiumarsi A Abstract Background: The first cases of proved COVID-19 in Iran were reported in February 2020 and has since rapidly spread worldwide. We aimed to clarify the clinical significance of hematologic parameters alteration in COVID-19. Methods: Different hematologic parameters were measured in 225 hospitalized COVID-19 patients in a tertiary care university hospital, during the peak of COVID-19 outbreak and their association with duration of hospitalization, ICU admission and especially mortality was analyzed. Results: Among a total ...
Source: Hematology - November 1, 2020 Category: Hematology Tags: Hematology Source Type: research

Real-world analysis of treatment patterns and clinical outcomes in patients with newly diagnosed chronic lymphocytic leukemia from seven Latin American countries.
CONCLUSION: Chlorambucil-based therapy, which has limited benefits, is frequently prescribed in Latin America. Prescribing novel agents for fludarabine-based therapy-ineligible patients with CLL is the need of the hour. Trial registration: ClinicalTrials.gov identifier: NCT02559583. PMID: 33095117 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - October 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Diaphragm ultrasonography in adults with sickle cell anemia: evaluation of morphological and functional aspects.
CONCLUSIONS: This study shows that adults with SCA had normal morphostructural aspects and absence of diaphragm dysfunction. Otherwise, they presented greater movement of the right hemidiaphragm during deep breathing and sniff test maneuvers. Despite the restrictive pattern and the reduction in RMS found in PFTs, the diaphragm of young adults with SCA did not have weakness or paralysis. PMID: 33095119 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - October 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Haploidentical stem cell transplantation vs matched unrelated donor transplantation in adults with hematologic malignancies: a systematic review and meta-analysis.
CONCLUSION: Results of this meta-analysis demonstrates that Haplo-SCT achieves comparable clinical outcomes compared to MUD-SCT in terms of OS, PFS, TRM and RR, but is better than MUD-SCT in terms of decreased aGVHD and cGVHD risk. Haplo-SCT is a valid option for patient needing urgent transplantation. PMID: 33054609 [PubMed - in process] (Source: Hematology)
Source: Hematology - October 20, 2020 Category: Hematology Tags: Hematology Source Type: research

Small PNH clones detected by fluorescent aerolysin predict a faster response to immunosuppressive therapy in patients with severe aplastic anaemia.
Authors: Ren X, Li X, Huo J, You Y, Huang J, Shao Y, Ge M, Huang Z, Zhang J, Wang M, Jin P, Nie N, Zheng Y Abstract Objectives: To clear the obscure conclusion on the prediction value of paroxysmal nocturnal haemoglobinuria (PNH) clones in severe aplastic anaemia (SAA) patients treated with immunosuppressive therapy (IST). Methods: We retrospectively analyzed 219 consecutive SAA patients treated with IST from October 2008 to October 2015 and evaluated the haematological responses to IST. Results: The presence of a PNH clone was detected in 55 (25.1%) patients prior to IST [37/88 by flow cytometry (FCM) and 18/131 b...
Source: Hematology - September 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Eltrombopag, oral immunosuppressant and androgen combination therapy in twelve patients with refractory severe aplastic anemia.
Conclusion: Eltrombopag, oral immunosuppressant and androgen combination therapy in patients with IST-refractory SAA is feasible and could restore multi-lineage hematopoiesis. Thrombosis risk of eltrombopag still needs to be monitored. PMID: 32915111 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - September 13, 2020 Category: Hematology Tags: Hematology Source Type: research

IgG4 plasma cell myeloma without clinical evidence of IgG4-related disease: a report of two cases.
Conclusion: These cases illustrate the importance of performing serum protein electrophoresis in tandem with IgG subclasses to distinguish between polyclonal and monoclonal increases in serum IgG4. The lack of typical IgG4-RD features in these two patients suggests that monoclonal elevation in serum IgG4 alone is insufficient to cause the organ damage characteristic of IgG4-RD. Larger studies of IgG myeloma subtypes are warranted to explore whether IgG1, IgG2, IgG3 and IgG4 myeloma differ in natural history and whether the interference with beta-2 microglobulin is specific to IgG4 monoclonal proteins. PMID: 32893754 [P...
Source: Hematology - September 8, 2020 Category: Hematology Tags: Hematology Source Type: research

Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab.
Conclusion: Overall resource use and costs for BTH are estimated to be lower for PNH patients receiving ravulizumab compared with eculizumab. PMID: 32856539 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 29, 2020 Category: Hematology Tags: Hematology Source Type: research

A novel EPB41 p.Trp704* mutation in a Korean patient with hereditary elliptocytosis: a case report.
Conclusion: The present study confirmed a novel mutation of the EPB41 gene that plays an important role in expanding the mutational distribution in HE-1. It could also be helpful for understanding the correlation between the genotype and phenotype in HE. PMID: 32807033 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 19, 2020 Category: Hematology Tags: Hematology Source Type: research

M élange intéressante: COVID-19, autologous transplants and multiple sclerosis.
Mélange intéressante: COVID-19, autologous transplants and multiple sclerosis. Hematology. 2020 Dec;25(1):320 Authors: Olivares Gazca JC, Gómez Almaguer D, Gale RP, Ruiz Argüelles GJ PMID: 32783598 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 15, 2020 Category: Hematology Tags: Hematology Source Type: research

Association between sickle cell disease and dental caries: a systematic review and meta-analysis.
Conclusions: The results revealed that compared with non-SCD individuals, patients with SCD did not suffer from worse dental caries. Considering the limitations, further well-designed studies are necessary to reveal the association between SCD and dental caries. PMID: 32783601 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 15, 2020 Category: Hematology Tags: Hematology Source Type: research

Identification of latent core genes and pathways associated with myelodysplastic syndromes based on integrated bioinformatics analysis.
Conclusion: The current study for the first time identified twelve latent indicators and their downstream targets, which might become significant biomarkers for worse clinical characteristics in MDS. PMID: 32772642 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 14, 2020 Category: Hematology Tags: Hematology Source Type: research

The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma.
Conclusion: The cut-offs for kappa/lambda ratio at ≤1/7 or ≥9 for diagnosis of multiple myeloma yielded the highest diagnostic accuracy. The suggested cut-offs could be of potential value in resource-limited laboratories. PMID: 32772824 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 14, 2020 Category: Hematology Tags: Hematology Source Type: research

Analysis of rare thalassemia caused by HS-40 regulatory site deletion.
Conclusion: The deletion of HS-40 regulatory site reduced expression of α-globin. HS-40 heterozygous deletion manifested as mild anemia, which was of microcytic hypochromic type. When compounded with -α3.7/αα, it manifested as Hb H disease; and when compounded with -SEA/αɑ, it manifested as Hb Bart's fetus. PMID: 32720864 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 29, 2020 Category: Hematology Tags: Hematology Source Type: research

Clinical analysis and literature review of a case with the myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis.
Conclusions: Our report provides a definite conceptual framework for a better understanding of the characteristics of MDS/MPN-RS-T. PMID: 32657243 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 15, 2020 Category: Hematology Tags: Hematology Source Type: research

Vulnerability of sickle cell disease persons to the COVID-19 in sub-Saharan Africa.
Authors: Tonen-Wolyec S, Marini Djang'eing'a R, Kambale-Kombi P, Tshilumba CK, Bélec L, Batina-Agasa S PMID: 32657260 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 15, 2020 Category: Hematology Tags: Hematology Source Type: research

Comprehensive screening for coexisting heterozygous α0-thalassemia in hemoglobin E trait.
Conclusion: Lower cutoff screening values can be used to exclude α0-thalassemia in the Hb E trait yielding a higher specificity in a normal RDW condition. This can save the cost and labor of DNA testing. PMID: 32633642 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 9, 2020 Category: Hematology Tags: Hematology Source Type: research

Expression and clinical significance of phospholipase D1 in de novo acute myeloid leukemia.
Conclusion: PLD1 represented a useful diagnostic marker and prognostic factor for AML. PMID: 32615908 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 5, 2020 Category: Hematology Tags: Hematology Source Type: research

Myeloproliferative neoplasms treated with hydroxyurea, pegylated interferon alpha-2A or ruxolitinib: clinicohematologic responses, quality-of-life changes and safety in the real-world setting.
Authors: Gill H, Leung GMK, Yim R, Lee P, Pang HH, Ip HW, Leung RYY, Li J, Panagiotou G, Ma ESK, Kwong YL Abstract Introduction: Real-world data of responses, quality-of-life (QOL) changes and adverse events in patients with myeloproliferative neoplasms (MPN) on conventional therapy (hydroxyurea ± anagrelide), pegylated interferon alpha-2A (PEG-IFNα-2A) or ruxolitinib are limited. Methods: We prospectively studied MPN patients receiving conventional therapy, PEG-IFNα-2A or ruxolitinib. Next-generation sequencing of 69 myeloid-related genes was performed. Clinicohematologic responses...
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Prognostic significance of Twist, ZEB1 and Slug in peripheral T-cell lymphomas.
Conclusion: ZEB1 and Slug may have potential clinical value for evaluating prognosis in PTCLs. The study size was small and heterogenous, and larger studies are warranted. PMID: 32567520 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

The effect of rat nerve growth factor combined with vitamin B on peripheral neuropathy in multiple myeloma patients.
Authors: Yan M, Li Y, Zeng H, Zhao X, Wu H, Qian W, Guo X Abstract Background: Peripheral neuropathy can induce marked disability and negative effects on quality of life and is the most common therapy-related complication in multiple myeloma patients treated with bortezomib. Currently, there is no useful method to prevent or treat it. So, it is necessary to study the clinical efficacy of rat nerve growth factor combined with vitamin B for the treatment of peripheral neuropathy in multiple myeloma patients. Methods: Sixty multiple myeloma patients who developed peripheral neuropathy after bortezomib-based chemothera...
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

The diagnostic and prognostic value of MRI in central nervous system involvement of acute myeloid leukemia: a retrospective cohort of 84 patients.
Conclusion: MRI manifestation of central infiltration in AML patients has certain characteristic findings, which is helpful to improve the diagnostic efficiency. Prognosis of MRI positive patients is relatively worse than that of MRI negative patients however there is no siginificant difference. PMID: 32567523 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Association between hospital admissions and healthcare provider communication for individuals with sickle cell disease.
Conclusions: Low ratings of provider communication were associated with more hospitalizations and readmissions in SCD, suggesting the need for interventions targeted at improving patient-provider communication which could decrease hospitalizations for this population. PMID: 32552526 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 21, 2020 Category: Hematology Tags: Hematology Source Type: research

Mutational landscape of patients with acute myeloid leukemia or myelodysplastic syndromes in the context of RUNX1 mutation.
Conclusion: RUNX1-mutated AML and MDS are associated with a different complex co-mutation cluster. Some co-mutations have certain influence on the clinical feature and CR rate in the context of RUNX1 mutation. PMID: 32476595 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 2, 2020 Category: Hematology Tags: Hematology Source Type: research

A multicentre retrospective study of primary breast diffuse large B-cell and high-grade B-cell lymphoma treatment strategies and survival.
Conclusion: Current treatments, including more intensive chemotherapy regimens, achieve good control of the disease. Novel drugs combined with cellular immunotherapy initially show promising therapeutic effects, and more clinical trials are required to confirm these effects further. PMID: 32476626 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 2, 2020 Category: Hematology Tags: Hematology Source Type: research

Increased circulating basic fibroblast growth factor levels in acute myeloid leukemia: a meta-analysis.
Authors: Song MZ, Mao YM, Wu J, Pan HF, Ye QL Abstract Background: Basic fibroblast growth factor (bFGF) plays an important role in the pathogenesis of acute myeloid leukemia (AML). Whether the levels of circulating bFGF are increased or not in untreated AML patients is still not clear. In order to acquire a more definite evaluation, a meta-analysis was performed.Material and methods: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for possible eligible articles. Forest plot was used to present the combined effect values and 95% confidence...
Source: Hematology - May 23, 2020 Category: Hematology Tags: Hematology Source Type: research

Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era.
Conclusion: Moderate anemia is a common concomitant symptom in CML-CP patients and is associated with high-risk CML, but its occurrence does not affect the survival of CML-CP patients in TKI era. PMID: 32432512 [PubMed - in process] (Source: Hematology)
Source: Hematology - May 22, 2020 Category: Hematology Tags: Hematology Source Type: research

Cytogenetic abnormalities in patients with newly diagnosed multiple myeloma as a secondary primary malignancy: a retrospective study.
Conclusions: RB1 gene deletions appear to be associated with MM that develops as an SPM. PMID: 32345147 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 30, 2020 Category: Hematology Tags: Hematology Source Type: research

Disappearance of monosomy 7 in a patient with aplastic anemia after eltrombopag treatment.
We present the case of a patient with aplastic anemia (AA) who was treated with eltrombopag. To the best of our knowledge, this is the first report of the disappearance of monosomy 7 after eltrombopag treatment. The patient was a 77-year-old woman with intraoral hematoma and purpura who was diagnosed with very severe AA with a normal karyotype. After combination therapy with rabbit antithymocyte globulin, cyclosporin, and granulocyte-colony-stimulating factor (G-CSF), pancytopenia transiently improved. When pancytopenia worsened again, the patient was administered darbepoetin alfa for renal anemia and danazol. Bone marrow ...
Source: Hematology - April 29, 2020 Category: Hematology Tags: Hematology Source Type: research

Identification of potential miRNA-mRNA interaction network in bone marrow T cells of acquired aplastic anemia.
Conclusion: The miRNA-mRNA network in our study show that hsa-mir-34a-5p, hsa-mir-195-5p, and hsa-mir-424-5p may regulate the T cell differentiation and plasticity by targeting histone gene expression and histone modification. PMID: 32338587 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 29, 2020 Category: Hematology Tags: Hematology Source Type: research

LncRNA SNHG4 regulates miR-10a/PTEN to inhibit the proliferation of acute myeloid leukemia cells.
Conclusion: In conclusion, SNHG4 may regulate miR-10a/PTEN to inhibit the proliferation of AML cells. PMID: 32319862 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 23, 2020 Category: Hematology Tags: Hematology Source Type: research

Up to half of patients diagnosed with chronic lymphocytic leukemia in M éxico may not require treatment.
Conclusion: CLL seems to be less aggressive in Mexican mestizos than in Caucasians; 43% of patients do not need treatment at all. PMID: 32268849 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 10, 2020 Category: Hematology Tags: Hematology Source Type: research

Economic burden of hemophilia A and B: a case in Iran.
Conclusion: Considering the significant economic burden of hemophilia and in order to reduce the costs, the following suggestions can be offered: provision of clotting factor concentrates domestically in accordance with the world standards, and providing specialized services and care to hemophilia patients in towns. PMID: 32249720 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 7, 2020 Category: Hematology Tags: Hematology Source Type: research

Congenital fibrinogen disorder caused by digenic mutations of the FGA and FGB genes.
Conclusion: This is the first report of digenic variants causing CFD, and these findings may improve understanding of the genetic architecture of CFD. PMID: 32228225 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 3, 2020 Category: Hematology Tags: Hematology Source Type: research

The association between antinuclear antibody and response to rituximab treatment in adult patients with primary immune thrombocytopenia.
Authors: Wang YM, Yu YF, Liu Y, Liu S, Hou M, Liu XG Abstract Background: Antinuclear antibodies (ANAs) can be detected in about 30% of patients with primary immune thrombocytopenia (ITP), yet their relationship with treatment response to rituximab remains elusive.Methods: we retrospectively reviewed the clinical records of hospitalized adult ITP patients who were treated with rituximab from three medical centers across China. Rituximab was given intravenously at 100 mg weekly for 4 weeks, or at a single dose of 375 mg/m2. All included patients had their ANAs tested before rituximab treatment.Results: A total o...
Source: Hematology - March 14, 2020 Category: Hematology Tags: Hematology Source Type: research

Expression of serum BMP6 and hepcidin in cancer-related anemia.
Authors: Cheng Z, Yan M, Lu Y, Pan XT Abstract Objective: To study the function of human bone morphogenetic protein-6 (BMP6) and hepcidin in cancer-related anemia.Methods: The levels of Hemoglobin (Hb), serum C-reactive protein (CRP), BMP6, hepcidin and ferritin (SF) were measured in 115 patients with solid tumors, who were divided into elevated CRP group and normal CRP group, and further divided into anemia subgroup and non-anemia subgroup according to the CRP level.Results: The prevalence of anemia was 53.9% in all patients. In the elevated CRP group, the levels of CRP, hepcidin and SF of the anemia subgroup were...
Source: Hematology - March 11, 2020 Category: Hematology Tags: Hematology Source Type: research

Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients.
This study is planned to investigate the prognostic role of pre-transplant soluble TIM-3 (sTIM-3) levels in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Methods: Pre-transplant serum sTIM-3 levels were measured in 177 allo-HSCT recipients [median age: 36(16-66) years; male/female: 111/66]. Results: Pre-transplant sTIM-3 levels were significantly higher in acute myeloid leukemia (AML) patients compared to acute lymphoblastic leukemia (ALL) patients (p = 0.01). Pre-transplant sTIM-3 levels were significantly lower in patients with abnormal cytogenetics (p = 0.017). Pr...
Source: Hematology - March 11, 2020 Category: Hematology Tags: Hematology Source Type: research

Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction.
Conclusion: These results confirm prior reports and support a mechanistic role for the inhibition of collagen-induced platelet aggregation in bleeding events among susceptible individuals receiving ibrutinib therapy. PMID: 32131714 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 7, 2020 Category: Hematology Tags: Hematology Source Type: research

The safety of modern intravenous iron infusions in patients with rheumatoid arthritis - a review of the literature.
Conclusion: We find significant evidence of safety and efficacy in more recent studies of larger cohorts of patients using newer, less immunogenic iron preparations. PMID: 32114962 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 4, 2020 Category: Hematology Tags: Hematology Source Type: research

WT1 overexpression predicted good outcomes in adult B-cell acute lymphoblastic leukemia patients receiving chemotherapy.
Conclusion: Therefore, testing for WT1 expression at the time of diagnosis may predict outcomes in adult B-ALL patients who receive only chemotherapy and who do not have the BCR-ABL fusion gene or KMT2A rearrangements. Allo-HSCT may improve the prognosis of patients with low WT1 transcript levels. PMID: 32122281 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 4, 2020 Category: Hematology Tags: Hematology Source Type: research

A novel compound heterozygous mutation in DGKE in a Chinese patient causes atypical hemolytic uremic syndrome.
Conclusions: Our study further expands the spectrum of the sequence variants reported in the DGKE gene and also indicates that different races may have different DGKE variants. Moreover, the altered structures and conformations, caused by DGKE mutations, disrupt the binding of DGKE with its partners, and leading to the occurrence of aHUS. PMID: 32091318 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 26, 2020 Category: Hematology Tags: Hematology Source Type: research

Physical exercise is safe and feasible in thrombocytopenic patients with hematologic malignancies: a narrative review.
Authors: Morishita S, Nakano J, Fu JB, Tsuji T Abstract Many studies have reported that physical exercise can improve the levels of function, quality of life (QoL), and fatigue in patients with hematologic malignancies. However, exercises should be prescribed with caution in patients with thrombocytopenia to prevent exercise-related bleeding. Some studies have suggested threshold platelet counts at which physical exercise can safely be performed. Herein, we review the current literature to determine the platelet count thresholds and types of physical exercise that may be prescribed to reduce the risk of exercise-re...
Source: Hematology - February 22, 2020 Category: Hematology Tags: Hematology Source Type: research

Students' knowledge on sickle cell disease in Kisangani, Democratic Republic of the Congo.
This study highlighted that the Kisangani university students' knowledge regarding SCD is poor and needs to be improved; education programs and motivational campaigns to be enhanced. PMID: 32070266 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 20, 2020 Category: Hematology Tags: Hematology Source Type: research

The relationship between interferon-gamma (INF- γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis.
The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis. Hematology. 2020 Dec;25(1):85-90 Authors: Deng S, Lin S, Shen J, Zeng Y Abstract Objective: This meta-analysis was designed to investigate the association between interferon-gamma (IFN-γ) polymorphisms and occurrence risk of aplastic anemia.Methods: Literature search was conducted in PubMed, Embase and Cochrane Library up to April 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by R 3.12.Results: Total five st...
Source: Hematology - February 19, 2020 Category: Hematology Tags: Hematology Source Type: research