Analysis of rare thalassemia caused by HS-40 regulatory site deletion.
Conclusion: The deletion of HS-40 regulatory site reduced expression of α-globin. HS-40 heterozygous deletion manifested as mild anemia, which was of microcytic hypochromic type. When compounded with -α3.7/αα, it manifested as Hb H disease; and when compounded with -SEA/αɑ, it manifested as Hb Bart's fetus. PMID: 32720864 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 29, 2020 Category: Hematology Tags: Hematology Source Type: research

Clinical analysis and literature review of a case with the myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis.
Conclusions: Our report provides a definite conceptual framework for a better understanding of the characteristics of MDS/MPN-RS-T. PMID: 32657243 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 15, 2020 Category: Hematology Tags: Hematology Source Type: research

Vulnerability of sickle cell disease persons to the COVID-19 in sub-Saharan Africa.
Authors: Tonen-Wolyec S, Marini Djang'eing'a R, Kambale-Kombi P, Tshilumba CK, Bélec L, Batina-Agasa S PMID: 32657260 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 15, 2020 Category: Hematology Tags: Hematology Source Type: research

Comprehensive screening for coexisting heterozygous α0-thalassemia in hemoglobin E trait.
Conclusion: Lower cutoff screening values can be used to exclude α0-thalassemia in the Hb E trait yielding a higher specificity in a normal RDW condition. This can save the cost and labor of DNA testing. PMID: 32633642 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 9, 2020 Category: Hematology Tags: Hematology Source Type: research

Expression and clinical significance of phospholipase D1 in de novo acute myeloid leukemia.
Conclusion: PLD1 represented a useful diagnostic marker and prognostic factor for AML. PMID: 32615908 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 5, 2020 Category: Hematology Tags: Hematology Source Type: research

Myeloproliferative neoplasms treated with hydroxyurea, pegylated interferon alpha-2A or ruxolitinib: clinicohematologic responses, quality-of-life changes and safety in the real-world setting.
Authors: Gill H, Leung GMK, Yim R, Lee P, Pang HH, Ip HW, Leung RYY, Li J, Panagiotou G, Ma ESK, Kwong YL Abstract Introduction: Real-world data of responses, quality-of-life (QOL) changes and adverse events in patients with myeloproliferative neoplasms (MPN) on conventional therapy (hydroxyurea ± anagrelide), pegylated interferon alpha-2A (PEG-IFNα-2A) or ruxolitinib are limited. Methods: We prospectively studied MPN patients receiving conventional therapy, PEG-IFNα-2A or ruxolitinib. Next-generation sequencing of 69 myeloid-related genes was performed. Clinicohematologic responses...
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Prognostic significance of Twist, ZEB1 and Slug in peripheral T-cell lymphomas.
Conclusion: ZEB1 and Slug may have potential clinical value for evaluating prognosis in PTCLs. The study size was small and heterogenous, and larger studies are warranted. PMID: 32567520 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

The effect of rat nerve growth factor combined with vitamin B on peripheral neuropathy in multiple myeloma patients.
Authors: Yan M, Li Y, Zeng H, Zhao X, Wu H, Qian W, Guo X Abstract Background: Peripheral neuropathy can induce marked disability and negative effects on quality of life and is the most common therapy-related complication in multiple myeloma patients treated with bortezomib. Currently, there is no useful method to prevent or treat it. So, it is necessary to study the clinical efficacy of rat nerve growth factor combined with vitamin B for the treatment of peripheral neuropathy in multiple myeloma patients. Methods: Sixty multiple myeloma patients who developed peripheral neuropathy after bortezomib-based chemothera...
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

The diagnostic and prognostic value of MRI in central nervous system involvement of acute myeloid leukemia: a retrospective cohort of 84 patients.
Conclusion: MRI manifestation of central infiltration in AML patients has certain characteristic findings, which is helpful to improve the diagnostic efficiency. Prognosis of MRI positive patients is relatively worse than that of MRI negative patients however there is no siginificant difference. PMID: 32567523 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 24, 2020 Category: Hematology Tags: Hematology Source Type: research

Association between hospital admissions and healthcare provider communication for individuals with sickle cell disease.
Conclusions: Low ratings of provider communication were associated with more hospitalizations and readmissions in SCD, suggesting the need for interventions targeted at improving patient-provider communication which could decrease hospitalizations for this population. PMID: 32552526 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 21, 2020 Category: Hematology Tags: Hematology Source Type: research

Mutational landscape of patients with acute myeloid leukemia or myelodysplastic syndromes in the context of RUNX1 mutation.
Conclusion: RUNX1-mutated AML and MDS are associated with a different complex co-mutation cluster. Some co-mutations have certain influence on the clinical feature and CR rate in the context of RUNX1 mutation. PMID: 32476595 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 2, 2020 Category: Hematology Tags: Hematology Source Type: research

A multicentre retrospective study of primary breast diffuse large B-cell and high-grade B-cell lymphoma treatment strategies and survival.
Conclusion: Current treatments, including more intensive chemotherapy regimens, achieve good control of the disease. Novel drugs combined with cellular immunotherapy initially show promising therapeutic effects, and more clinical trials are required to confirm these effects further. PMID: 32476626 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 2, 2020 Category: Hematology Tags: Hematology Source Type: research

Increased circulating basic fibroblast growth factor levels in acute myeloid leukemia: a meta-analysis.
Authors: Song MZ, Mao YM, Wu J, Pan HF, Ye QL Abstract Background: Basic fibroblast growth factor (bFGF) plays an important role in the pathogenesis of acute myeloid leukemia (AML). Whether the levels of circulating bFGF are increased or not in untreated AML patients is still not clear. In order to acquire a more definite evaluation, a meta-analysis was performed.Material and methods: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases for possible eligible articles. Forest plot was used to present the combined effect values and 95% confidence...
Source: Hematology - May 23, 2020 Category: Hematology Tags: Hematology Source Type: research

Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era.
Conclusion: Moderate anemia is a common concomitant symptom in CML-CP patients and is associated with high-risk CML, but its occurrence does not affect the survival of CML-CP patients in TKI era. PMID: 32432512 [PubMed - in process] (Source: Hematology)
Source: Hematology - May 22, 2020 Category: Hematology Tags: Hematology Source Type: research

Cytogenetic abnormalities in patients with newly diagnosed multiple myeloma as a secondary primary malignancy: a retrospective study.
Conclusions: RB1 gene deletions appear to be associated with MM that develops as an SPM. PMID: 32345147 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 30, 2020 Category: Hematology Tags: Hematology Source Type: research

Disappearance of monosomy 7 in a patient with aplastic anemia after eltrombopag treatment.
We present the case of a patient with aplastic anemia (AA) who was treated with eltrombopag. To the best of our knowledge, this is the first report of the disappearance of monosomy 7 after eltrombopag treatment. The patient was a 77-year-old woman with intraoral hematoma and purpura who was diagnosed with very severe AA with a normal karyotype. After combination therapy with rabbit antithymocyte globulin, cyclosporin, and granulocyte-colony-stimulating factor (G-CSF), pancytopenia transiently improved. When pancytopenia worsened again, the patient was administered darbepoetin alfa for renal anemia and danazol. Bone marrow ...
Source: Hematology - April 29, 2020 Category: Hematology Tags: Hematology Source Type: research

Identification of potential miRNA-mRNA interaction network in bone marrow T cells of acquired aplastic anemia.
Conclusion: The miRNA-mRNA network in our study show that hsa-mir-34a-5p, hsa-mir-195-5p, and hsa-mir-424-5p may regulate the T cell differentiation and plasticity by targeting histone gene expression and histone modification. PMID: 32338587 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 29, 2020 Category: Hematology Tags: Hematology Source Type: research

LncRNA SNHG4 regulates miR-10a/PTEN to inhibit the proliferation of acute myeloid leukemia cells.
Conclusion: In conclusion, SNHG4 may regulate miR-10a/PTEN to inhibit the proliferation of AML cells. PMID: 32319862 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 23, 2020 Category: Hematology Tags: Hematology Source Type: research

Up to half of patients diagnosed with chronic lymphocytic leukemia in M éxico may not require treatment.
Conclusion: CLL seems to be less aggressive in Mexican mestizos than in Caucasians; 43% of patients do not need treatment at all. PMID: 32268849 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 10, 2020 Category: Hematology Tags: Hematology Source Type: research

Economic burden of hemophilia A and B: a case in Iran.
Conclusion: Considering the significant economic burden of hemophilia and in order to reduce the costs, the following suggestions can be offered: provision of clotting factor concentrates domestically in accordance with the world standards, and providing specialized services and care to hemophilia patients in towns. PMID: 32249720 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 8, 2020 Category: Hematology Tags: Hematology Source Type: research

Congenital fibrinogen disorder caused by digenic mutations of the FGA and FGB genes.
Conclusion: This is the first report of digenic variants causing CFD, and these findings may improve understanding of the genetic architecture of CFD. PMID: 32228225 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 3, 2020 Category: Hematology Tags: Hematology Source Type: research

The association between antinuclear antibody and response to rituximab treatment in adult patients with primary immune thrombocytopenia.
Authors: Wang YM, Yu YF, Liu Y, Liu S, Hou M, Liu XG Abstract Background: Antinuclear antibodies (ANAs) can be detected in about 30% of patients with primary immune thrombocytopenia (ITP), yet their relationship with treatment response to rituximab remains elusive.Methods: we retrospectively reviewed the clinical records of hospitalized adult ITP patients who were treated with rituximab from three medical centers across China. Rituximab was given intravenously at 100 mg weekly for 4 weeks, or at a single dose of 375 mg/m2. All included patients had their ANAs tested before rituximab treatment.Results: A total o...
Source: Hematology - March 14, 2020 Category: Hematology Tags: Hematology Source Type: research

Expression of serum BMP6 and hepcidin in cancer-related anemia.
Authors: Cheng Z, Yan M, Lu Y, Pan XT Abstract Objective: To study the function of human bone morphogenetic protein-6 (BMP6) and hepcidin in cancer-related anemia.Methods: The levels of Hemoglobin (Hb), serum C-reactive protein (CRP), BMP6, hepcidin and ferritin (SF) were measured in 115 patients with solid tumors, who were divided into elevated CRP group and normal CRP group, and further divided into anemia subgroup and non-anemia subgroup according to the CRP level.Results: The prevalence of anemia was 53.9% in all patients. In the elevated CRP group, the levels of CRP, hepcidin and SF of the anemia subgroup were...
Source: Hematology - March 11, 2020 Category: Hematology Tags: Hematology Source Type: research

Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients.
This study is planned to investigate the prognostic role of pre-transplant soluble TIM-3 (sTIM-3) levels in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Methods: Pre-transplant serum sTIM-3 levels were measured in 177 allo-HSCT recipients [median age: 36(16-66) years; male/female: 111/66]. Results: Pre-transplant sTIM-3 levels were significantly higher in acute myeloid leukemia (AML) patients compared to acute lymphoblastic leukemia (ALL) patients (p = 0.01). Pre-transplant sTIM-3 levels were significantly lower in patients with abnormal cytogenetics (p = 0.017). Pr...
Source: Hematology - March 11, 2020 Category: Hematology Tags: Hematology Source Type: research

Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction.
Conclusion: These results confirm prior reports and support a mechanistic role for the inhibition of collagen-induced platelet aggregation in bleeding events among susceptible individuals receiving ibrutinib therapy. PMID: 32131714 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 7, 2020 Category: Hematology Tags: Hematology Source Type: research

The safety of modern intravenous iron infusions in patients with rheumatoid arthritis - a review of the literature.
Conclusion: We find significant evidence of safety and efficacy in more recent studies of larger cohorts of patients using newer, less immunogenic iron preparations. PMID: 32114962 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 4, 2020 Category: Hematology Tags: Hematology Source Type: research

WT1 overexpression predicted good outcomes in adult B-cell acute lymphoblastic leukemia patients receiving chemotherapy.
Conclusion: Therefore, testing for WT1 expression at the time of diagnosis may predict outcomes in adult B-ALL patients who receive only chemotherapy and who do not have the BCR-ABL fusion gene or KMT2A rearrangements. Allo-HSCT may improve the prognosis of patients with low WT1 transcript levels. PMID: 32122281 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 4, 2020 Category: Hematology Tags: Hematology Source Type: research

A novel compound heterozygous mutation in DGKE in a Chinese patient causes atypical hemolytic uremic syndrome.
Conclusions: Our study further expands the spectrum of the sequence variants reported in the DGKE gene and also indicates that different races may have different DGKE variants. Moreover, the altered structures and conformations, caused by DGKE mutations, disrupt the binding of DGKE with its partners, and leading to the occurrence of aHUS. PMID: 32091318 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 26, 2020 Category: Hematology Tags: Hematology Source Type: research

Physical exercise is safe and feasible in thrombocytopenic patients with hematologic malignancies: a narrative review.
Authors: Morishita S, Nakano J, Fu JB, Tsuji T Abstract Many studies have reported that physical exercise can improve the levels of function, quality of life (QoL), and fatigue in patients with hematologic malignancies. However, exercises should be prescribed with caution in patients with thrombocytopenia to prevent exercise-related bleeding. Some studies have suggested threshold platelet counts at which physical exercise can safely be performed. Herein, we review the current literature to determine the platelet count thresholds and types of physical exercise that may be prescribed to reduce the risk of exercise-re...
Source: Hematology - February 22, 2020 Category: Hematology Tags: Hematology Source Type: research

Students' knowledge on sickle cell disease in Kisangani, Democratic Republic of the Congo.
This study highlighted that the Kisangani university students' knowledge regarding SCD is poor and needs to be improved; education programs and motivational campaigns to be enhanced. PMID: 32070266 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 20, 2020 Category: Hematology Tags: Hematology Source Type: research

The relationship between interferon-gamma (INF- γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis.
The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis. Hematology. 2020 Dec;25(1):85-90 Authors: Deng S, Lin S, Shen J, Zeng Y Abstract Objective: This meta-analysis was designed to investigate the association between interferon-gamma (IFN-γ) polymorphisms and occurrence risk of aplastic anemia.Methods: Literature search was conducted in PubMed, Embase and Cochrane Library up to April 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by R 3.12.Results: Total five st...
Source: Hematology - February 19, 2020 Category: Hematology Tags: Hematology Source Type: research

The target hemoglobin content values of reticulocytes for efficient anemia improvement are achieved by low ferritin levels and moderate transferrin saturation: a retrospective observational study.
Conclusion: Therefore, controlling hepcidin levels to within approximately 20-70 ng/mL may prevent iron deficiency and reduced Hb synthesis, and may thus facilitate effective iron utilization in hematopoiesis. PMID: 32009585 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 6, 2020 Category: Hematology Tags: Hematology Source Type: research

Clinical features and prognosis of normal karyotype acute myeloid leukemia pediatric patients with WT1 mutations: an analysis based on TCGA database.
Authors: Xu J, Zhang Y, Hu J, Ren Y, Wang H Abstract Objectives: To explore the clinical features and prognosis of normal karyotype acute myeloid leukemia (NK-AML) pediatric patients with WT1 mutations.Methods: The clinical data and prognostic information of 220 NK-AML pediatric patients were selected from target-AML project of The Cancer Genome Atlas (TCGA) database. Survival analyses were performed for NK-AML pediatric patients with different combinations of mutations.Results: We found that 28(12.7%) NK-AML patients harbored WT1 mutations. The positive rate of FLT3-ITD in the WT1-mutated group was higher than tha...
Source: Hematology - February 6, 2020 Category: Hematology Tags: Hematology Source Type: research

Distribution of sickle cell disease and assessment of risk factors based on transcranial Doppler values in the Gulf region.
Authors: Wali Y, Kini V, Yassin MA Abstract Background/Objective: Stroke is a potentially fatal complication of sickle cell disease (SCD). Transcranial Doppler (TCD) is useful at identifying increased risk of stroke in children with SCD and vasospasm after subarachnoid hemorrhage. The main aim of this study was to determine the proportion of patients with SCD in the Gulf region who are at a high risk of stroke, as determined by TCD.Methods: This multicenter (Oman, Qatar, and UAE), descriptive, cross-sectional study in patients (aged 2-16 years) with SCD included a baseline visit, 1 follow-up visit for patients with...
Source: Hematology - January 29, 2020 Category: Hematology Tags: Hematology Source Type: research

Direct oral anticoagulants for thromboprophylaxis in ambulatory patients with cancer.
Authors: Wang Y, Wang M, Ni Y, Liang Z Abstract Background: Venous thromboembolism (VTE) is a common complication in cancer patients. We aim to evaluate the effect and safety of direct oral anticoagulants (DOACs) as primary prophylaxis in ambulatory cancer patients.Methods: We conducted a literature search in PubMed, EMBASE and ClinicalTrials for studies that evaluated DOACs for thromboprophylaxis in cancer patients. RevMan 5.3 software was used for this meta-analysis.Results: Three randomized controlled trials (RCTs) with a total of 1465 patients were pooled in the meta-analysis. DOACs significantly reduced the sy...
Source: Hematology - January 29, 2020 Category: Hematology Tags: Hematology Source Type: research

Donor CMV-specific cytotoxic T lymphocytes successfully treated drug-resistant cytomegalovirus encephalitis after allogeneic hematopoietic stem cell transplantation.
Conclusions: The intravenous/intratheca administration of donor CMV-specific CTLs may be a safe and effective treatment for CMV encephalitis, especially for patients who suffered from drug-resistant CMV infection. PMID: 31906810 [PubMed - in process] (Source: Hematology)
Source: Hematology - January 9, 2020 Category: Hematology Tags: Hematology Source Type: research

Epidemiology of aplastic anemia: a study of 1324 cases.
Conclusion: Younger age, male predominance and higher consanguinity point toward genetic factors in AA etiology among the South Asian population. PMID: 31906834 [PubMed - in process] (Source: Hematology)
Source: Hematology - January 9, 2020 Category: Hematology Tags: Hematology Source Type: research

Investigation on glucocorticoid receptors within platelets from adult patients with immune thrombocytopenia.
Authors: Yung KC, Xu CW, Zhang ZW, Yu WJ, Li Q, Xu XR, Han YF, Wang XJ, Yin J Abstract Objective: The expression of glucocorticoid receptors within platelets from newly diagnosed Immune Thrombocytopenia (ITP) patients in the adult was investigated.Methods: GR expression in platelets from newly diagnosed ITP patients and healthy controls was measured using flow cytometry. Subsequently, platelets RNA and proteins were isolated and used for confirming the flow cytometry results by using RT-qPCR and ELISA.Results: Flow cytometry showed that the percentages of platelets expressing GRα and GRβ from ITP patient...
Source: Hematology - January 7, 2020 Category: Hematology Tags: Hematology Source Type: research

A sporadic MYH9-related disease in a Chinese boy with p.A95T mutation.
Authors: Zhang W, Lian X, Sun Y, Hao J PMID: 31888422 [PubMed - in process] (Source: Hematology)
Source: Hematology - January 2, 2020 Category: Hematology Tags: Hematology Source Type: research

Anemia in centenarians: prevalence and association with kidney function.
The objective of this study was to determine the prevalence of anemia and examine the relationship between anemia and a decline in kidney function in Chinese centenarians.Methods: We conducted a population-based cross-sectional study of a sample of 1002 Chinese centenarians (180 men and 822 women) from 2014 to 2016. Anemia was defined as a hemoglobin level of
Source: Hematology - December 23, 2019 Category: Hematology Tags: Hematology Source Type: research

Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency.
Conclusion: These results warrant further investigation into the efficacy of rVIIa-FP to control and prevent bleeding in patients with FVII deficiency. PMID: 31852380 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 21, 2019 Category: Hematology Tags: Hematology Source Type: research

Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients.
Conclusion: Iron overload can increase EPO resistance and the expression of SOCS1, inhibit the expression of STAT5 and BCL2L1. ICT could allivation of EPO resistance. PMID: 31838956 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 18, 2019 Category: Hematology Tags: Hematology Source Type: research

T-lymphocyte subsets and Th1/Th2 cytokines in convalescent patients with Epstein-Barr virus-associated aplastic anemia.
Conclusions: EBV-DNA copy number in AA patients was higher than in normal controls. Both AA and EBV infection may cause changes in the levels of T-lymphocyte subsets. We recommend monitoring the changes in the immune function and EBV infection simultaneously in AA patients, especially following immunosuppressive therapy. PMID: 31842718 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 18, 2019 Category: Hematology Tags: Hematology Source Type: research

ISH Newsletter.
Authors: PMID: 31793404 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Frequency of iron deficiency anemia in pregnant and non-pregnant women suffering from restless legs syndrome.
This study also included a control group of 231 age-compatible non-pregnant women. Women who met the international criteria for diagnosing the syndrome filled in a sociodemographic questionnaire.Results. A statistically significant association between the existence of iron deficiency anemia and RLS in the sample of the examined women was proven (p 
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Disordered bone metabolism in hereditary spherocytosis patients.
Conclusion: Hereditary spherocytosis patients should be followed closely in terms of development, puberty, bone health as they are in other hemolytic anemias. Nutritional recommendations, vitamin D supplementation, physical activity should be advised to protect bone health. PMID: 31793406 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Multivariate logistic analysis of predictors of response to immunosuppressive therapy in children with aplastic anemia: a double-center study.
CONCLUSION: Duration of AA, ANC and decreased ALC rate after IST might predict the response to IST, among which the rate of decreased ALC after IST is the most important predictive factor. PMID: 31793407 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Adjuvant radiotherapy and chemotherapy in early-stage diffuse large B cell lymphoma of head and neck with extranodal involvement.
Conclusion: The addition of RT to CT resulted in longer OS in patients with limited stage head and neck DLBCL with extranodal involvement. PMID: 31793408 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

New data on FII, FV, FIX and thrombomodulin defects: blood keeps clotting in normal and in peculiar ways.
Conclusions: these new coagulation defects have great implications in the clinical and laboratory approach to the coagulation disorders. They have demonstrated that a prothrombin defect may be associated with thrombosis, that a mild bleeding tendency may occur despite normal Factor V levels and that high levels of plasmatic thrombomodulin may be associated with mild bleeding. PMID: 31793409 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Association between tumor necrosis factor alpha gene polymorphisms and multiple myeloma risk: an updated meta-analysis.
CONCLUSION: Our findings indicate that the 'TT vs. CC' and 'TT vs. CC + TC' of TNFα-857 C/T are correlated with MM risk. TNFα-857 C/T may be a risk factor for MM development. There is no association between TNFα-238/-308 polymorphisms and MM risk. PMID: 31793411 [PubMed - in process] (Source: Hematology)
Source: Hematology - December 4, 2019 Category: Hematology Tags: Hematology Source Type: research