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Immune dysregulation in primary immune thrombocytopenia patients.
CONCLUSION: ITP patients presented with a high CD4/CD8 ratio and low levels of Tregs and NK cells, suggesting that immune deregulation was involved in the pathogenesis of ITP. The pre-treated immune status of ITP patients may not be related to the curative effect. Tregs significantly increased in the effective group post-treatment, highlighting that the mechanism of restoring Tregs may be involved in the treatment of ITP. However, whether or not the targeted regulation of Tregs is an effective treatment for ITP still requires further studies. PMID: 29409398 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Danazol increases T regulatory cells in patients with aplastic anemia.
Authors: Khurana H, Malhotra P, Sachdeva MU, Varma N, Bose P, Yanamandra U, Varma S, Khadwal A, Lad D, Prakash G Abstract OBJECTIVES: Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to study the role of CD4+ CD25high CD127low FoxP3+ T regulatory cells (T-regs) in the pathophysiology of AA and their response to treatment with Danazol alone or in combination with immunosuppressive treatment (IST). METHODS: T-regs' percentages of 25 acquired idiopathic AA patients and 25 healthy controls who completed study protocol were analyzed by p...
Source: Hematology - February 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients.
CONCLUSION: These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma. ABBREVIATIONS: Mda-7/IL-24: melanoma differentiation associated gene7/interleukin 24; FCM: flow cytometry; Ecog: Eastern Cooperative Oncology Group; IPI: International lymphoma prognosis index. PMID: 29415639 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Eliezer Rachmilewitz (1935-2017).
Authors: PMID: 29400141 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 6, 2018 Category: Hematology Tags: Hematology Source Type: research

Dyspareunia is associated with chronic pain in premenopausal women with sickle cell disease.
CONCLUSION: Dyspareunia is common in women with SCD, and more common in women with SCD and chronic pain. Providers should assess women with SCD for dyspareunia, especially those with a chronic pain syndrome. PMID: 29376481 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 30, 2018 Category: Hematology Tags: Hematology Source Type: research

Corrigendum.
Authors: PMID: 29351728 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 22, 2018 Category: Hematology Tags: Hematology Source Type: research

Expression and role of granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) and granulocyte colony-stimulating factor receptor (G-CSFR) on Ph-positive acute B lymphoblastic leukemia.
CONCLUSION: We demonstrated high expression levels of GM-CSFR and G-CSFR, as well as their promotable role for viability in ph + ALL cells. We further found that rhG-CSF influenced the sensitivity of SUP-B15 cells to TKIs. PMID: 29338593 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Utility of mean sphered cell volume and mean reticulocyte volume for the diagnosis of hereditary spherocytosis.
Authors: Arora RD, Dass J, Maydeo S, Arya V, Kotwal J, Bhargava M Abstract INTRODUCTION: Hereditary spherocytosis (HS) is the most common congenital hemolytic anemia, characterized by anemia, jaundice, and splenomegaly. The diagnosis of HS relies on symptoms of hemolysis, a family history of HS, and a positive laboratory test which is usually the osmotic fragility test (OFT). We conducted a study to assess the utility of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), mean sphered cell volume (MSCV), and mean reticulocyte volume (MRV) in the diagnosis of HS and if these are helpful ...
Source: Hematology - January 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Adjuvant radiotherapy in patients with diffuse large B-cell lymphoma in advanced stage (III/IV) improves the outcome in the rituximab era.
Authors: Avilès A, Nambo MJ, Calva A, Neri N, Cleto S, Silva L Abstract OBJECTIVES: To assess the efficacy and toxicity of adjuvant radiotherapy (RT) in patients with diffuse large B-cell lymphoma (DLBCL) and nodal bulky disease, on complete response, after six cycles of RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone), we began an open-label clinical trial in a large cohort with longer follow-up to evaluate the outcome measured from progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS: Between 2006 and 2010, 258 consecutive patients with DLBCL and n...
Source: Hematology - January 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Prevalence of iron deficiency in a total joint surgery population.
Authors: Waters JH, Johnson P, Yazer MH Abstract BACKGROUND: Iron deficiency without anemia has been associated with decreases in functional work capacity and fatigue. The aim of this study was to determine the prevalence of iron deficiency without anemia in a preoperative cohort of orthopedic patients and to determine if iron deficiency is a condition which warrants inclusion into a prehabilitation program prior to surgery. METHODS: One hundred consecutive patients going through preoperative testing for total joint replacement were enrolled in the study. In addition to the standard preoperative complete blood ...
Source: Hematology - January 12, 2018 Category: Hematology Tags: Hematology Source Type: research

Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?
Authors: Sal E, Yenicesu I, Celik N, Pasaoglu H, Celik B, Pasaoglu OT, Kaya Z, Kocak U, Camurdan O, Bideci A, Cinaz P Abstract OBJECTIVES: Iron deficiency is common in obese children although the underlying mechanism is unclear. The aim of this study was to investigate the associations between iron parameters, leptin, hepcidin and adiponectin levels in obese children. METHODS: A total of 237 children, ranging in age from 5 to 18 years, 180 with primary obesity and 57 healthy children and adolescents, were enrolled. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, leptin, hepcidin...
Source: Hematology - January 12, 2018 Category: Hematology Tags: Hematology Source Type: research

Pathogenicity analysis of variations and prenatal diagnosis in a hereditary coagulation factor XIII deficiency family.
DISCUSSION: We first established the PND procedure with pathogenicity assessment in FXIIID patients. The F13A gene mutations' spectrum of the Chinese Han population was enriched. PMID: 29307277 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

Incidence of Fanconi anaemia in phenotypically normal aplastic anaemia patients in West Bengal.
CONCLUSION: This observation may indicate that stress cytogenetics analysis of phenotypically normal AA patients (≤50 years) is essential for the improvement of the treatment procedure. PMID: 29307285 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

The potential association of CMV-specific CD8+ T lymphocyte reconstitution with the risk of CMV reactivation and persistency in post allogeneic stem cell transplant patients.
CONCLUSION: CMV-specific CD8+ cells can help in categorizing patients into risk groups: (early recovery/low risk) and (delayed recovery/increased risk), this tool may guide clinicians in the selection of patients who may profit from prophylactic antiviral therapy and frequent viral monitoring. PMID: 29313439 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

Thrombopoietin and its receptor expression in pediatric patients with chronic immune thrombocytopenia.
This study aimed to determine whether thrombopoietin (TPO) and its receptor c-mannosylation of the TPO receptor (c-Mpl) have an impact on childhood cITP. METHODS: Sixty-four patients with newly diagnosed ITP (nITP), 64 patients with persistent ITP, 80 patients with cITP, and 64 healthy children (control) were enrolled in this study. Plasma TPO was measured with an ELISA, and c-Mpl was determined by flow cytometry. RESULTS: Plasma TPO levels showed differences among the four groups (p = 0.001). TPO levels in the cITP group were significantly decreased compared to those in the nITP group (p 
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting.
CONCLUSION: In a routine haematological practice, the use of eltrombopag in AA patients was feasible, safe, and associated with very favourable responses. PMID: 29303047 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 7, 2018 Category: Hematology Tags: Hematology Source Type: research

Is there a difference in phenotype between males and females with non-transfusion-dependent thalassemia? A cross-sectional evaluation.
CONCLUSION: This data should be considered in studies with experimental treatments aiming to correct anemia in patients with non-transfusion-dependent thalassemia. It should probably also be taken into account in order to set up different transfusion regimens among genders in transfusion-dependent patients. PMID: 29303050 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 7, 2018 Category: Hematology Tags: Hematology Source Type: research

A patient with oxaliplatin immune-induced syndrome (OIIS) who also developed leucovorin and palonosetron-associated thrombocytopenia.
We report a case of an 83 year old man who developed oxaliplatin immune-induced syndrome (OIIS) after his 19th cycle of FOLFOX (5FU, leucovorin, oxaliplatin). When oxaliplatin was omitted from his next cycle of chemotherapy he continues to show signs of drug-induced immune thrombocytopenia (DITP) and was found to have drug-dependent, platelet-reactive antibodies (DDPA) to leucovorin and palonosetron as well as oxaliplatin. METHODS: The patient was admitted for monitoring but required no transfusions and thrombocytopenia resolved without treatment during his first admission. Drug-dependent antibody testing was performed...
Source: Hematology - December 31, 2017 Category: Hematology Tags: Hematology Source Type: research

Thromboembolism following cesarean section: a retrospective study.
DISCUSSION: Hypertension and the presence of varicose veins were associated with TE following CS. Larger cohort analyses are required to confirm these associations so that risk scores incorporating these characteristics may accurately predict the occurrence of TE. PMID: 29264952 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 23, 2017 Category: Hematology Tags: Hematology Source Type: research

Balancing relapses versus cognitive impairment in primary central nervous system lymphoma: a single-center experience.
CONCLUSION: The low-dose WBRT consolidation is associated with lower PCNSL relapses with only mild neurocognitive toxicity. PMID: 29256330 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 21, 2017 Category: Hematology Tags: Hematology Source Type: research

The clinical significance of FLT3 ITD mutation on the prognosis of adult acute promyelocytic leukemia.
CONCLUSIONS: The results suggested that FLT3 ITD mutations could become an indicator of poor prognosis of APL, and these patients should receive more intensive therapy according to current guidelines. PMID: 29251252 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 20, 2017 Category: Hematology Tags: Hematology Source Type: research

Understanding of the significance and health implications of asplenia in a cohort of patients with haemaglobinopathy: possible benefits of a spleen registry.
CONCLUSION: This study examined knowledge and attitudes about splenectomy in a cohort of haemoglobinopathy patients in an Australian tertiary referral centre. The majority had good or fair knowledge with a strong association of some elements of post-splenectomy care with being placed on a spleen registry and having received targeted education. Implementation of systematic approaches by medical staff is likely to be the main benefit of a clinical registry approach in this setting. PMID: 29237357 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 15, 2017 Category: Hematology Tags: Hematology Source Type: research

Clinical characteristics and outcome of childhood acute promyelocitic leukemia (APL) in Saudi Arabia: a multicenter SAPHOS leukemia group study.
CONCLUSIONS: Access to modern care is likely to be a critical factor in successful and comparable outcomes of childhood APL across the globe. In the present study, utilizing a cytarabine-containing protocol improved outcome of high-risk pediatric patients with APL. PMID: 29212418 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 8, 2017 Category: Hematology Tags: Hematology Source Type: research

Antineoplastic chemotherapy in Jehovah's Witness patients with acute myelogenous leukemia refusing blood products - a matched pair analysis.
CONCLUSION: Reduced dose chemotherapy without transfusion support in JW suffering from AML is associated with a lower rate of remission, high mortality by severe anemia and very low chances for long-term remissions. Less hematotoxic treatment options including hypomethylating agents or molecular targeted therapies with intensive consolidation after improvement of bone marrow function are promising for these patients but need further investigation. PMID: 29212421 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 8, 2017 Category: Hematology Tags: Hematology Source Type: research

Protein-protein interaction networks and different clustering analysis in Burkitt's lymphoma.
CONCLUSION: In this study, the use of combined algorithms to analyse gene interactions provides a new perspective for network-based analysis. The results of this study reveal new insights into the molecular mechanisms underlying BL, which may be novel therapeutic targets for disease management and may provide a bioinformatic basis for the further understanding of BL. PMID: 29189103 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - December 4, 2017 Category: Hematology Tags: Hematology Source Type: research

Announcement.
Authors: PMID: 29173124 [PubMed - in process] (Source: Hematology)
Source: Hematology - November 28, 2017 Category: Hematology Tags: Hematology Source Type: research

Prognostic impact of CD200 and CD56 expression in adult acute lymphoblastic leukemia patients.
CONCLUSIONS: CD200(+) and/or CD56(+) positive expression in B-ALL patients at diagnosis is a poor prognostic biomarker. Identification of CD200(+) and CD56(+) expression at diagnosis is recommended for a better stratification of adult B-ALL patients. PMID: 29161980 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 24, 2017 Category: Hematology Tags: Hematology Source Type: research

Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major.
Authors: Kalbassi S, Younesi MR, Asgary V Abstract BACKGROUND: Regarding the importance of oral and dental health in patients with hemoglobinopathies and also due to the different results of different studies in this background, in patients with beta thalassemia (BTM) and sickle cell disease (SCD), this study aimed to evaluate and compare the oral and dental manifestations of patients with BTM and SCD. MATERIAL AND METHODS: In this cross-sectional study during the years 2014-2017, a total of 175 patients (with documented BTM or SCD attending to Tehran, Mashhad, Isfahan, and Tabriz cities central hospitals) were...
Source: Hematology - November 24, 2017 Category: Hematology Tags: Hematology Source Type: research

A structure-function analysis in patients with prekallikrein deficiency.
CONCLUSIONS: Despite the paucity of cases, it was established that the majority of mutations involved the catalytic domain. It is auspicable that future reports of patients with this disorder should include molecular studies. This would certainly contribute to the understanding of the contact phase of blood coagulation. PMID: 29165051 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 24, 2017 Category: Hematology Tags: Hematology Source Type: research

Blood transfusion versus hydroxyurea in beta-thalassemia in Iran: a cost-effectiveness study.
CONCLUSION: The results showed that the cost effectiveness of using hydroxyurea was more than that of blood transfusion. Therefore, it is recommended that the use of hydroxyurea in the treatment of patients with beta-thalassemia intermedia would become the first priority, and more basic and supplementary insurance coverage for treating such patients using hydroxyurea should be considered. PMID: 29157136 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 23, 2017 Category: Hematology Tags: Hematology Source Type: research

Modulation of hepcidin expression by normal control and beta0-thalassemia/Hb E erythroblasts.
CONCLUSION: The in vitro cell system developed here allows further investigation into the processes mediating erythroid cell suppression of liver hepcidin expression in both normal and pathological states. PMID: 29157161 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 23, 2017 Category: Hematology Tags: Hematology Source Type: research

β(S) globin gene haplotype and the stroke risk among Egyptian children with sickle cell disease.
β(S) globin gene haplotype and the stroke risk among Egyptian children with sickle cell disease. Hematology. 2017 Nov 20;:1-6 Authors: Abou-Elew HH, Youssry I, Hefny S, Hashem RH, Fouad N, Zayed RA Abstract BACKGROUND AND AIM OF WORK: Sickle cell disease (SCD) is an inherited disease of the beta globin gene. The β(S) globin gene haplotypes are Senegal, Benin, Bantu, Cameroon, Arab-Indian and atypical haplotypes. In SCD, stroke is a life-threatening event in both adults and children. In light of paucity of studies on β(S) globin gene haplotypes in Egypt, we aimed to determine β(S) gl...
Source: Hematology - November 23, 2017 Category: Hematology Tags: Hematology Source Type: research

Co-inheritance of HBB:c.-106G   >  C, a rare single nucleotide variation at position -56 relative to transcription initiation site, with other known mutations in the globin clusters.
Conclusion This is another example of rare or new nucleotide variations whose identification and characterization is crucial in order to carry out appropriate genetic counselling to a potential risk couple. PMID: 29157184 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 23, 2017 Category: Hematology Tags: Hematology Source Type: research

Repression of oxidative phosphorylation sensitizes leukemia cell lines to cytarabine.
CONCLUSION: Our results suggest a new property of CAPE, which is oxphos repression, and a presumptive link between altered metabolism and drug resistance. PMID: 29139328 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 17, 2017 Category: Hematology Tags: Hematology Source Type: research

TGF- β1 and CXCL12 modulate proliferation and chemotherapy sensitivity of acute myeloid leukemia cells co-cultured with multipotent mesenchymal stromal cells.
CONCLUSION: These findings suggest a strong supporting affinity between MSCs and AML cells within the leukemic niche, where TGF-β1 and CXCL12 pathways play an important role. PMID: 29140182 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 17, 2017 Category: Hematology Tags: Hematology Source Type: research

Investigation of the differences between the Tibetan and Han populations in the hemoglobin-oxygen affinity of red blood cells and in the adaptation to high-altitude environments.
CONCLUSIONS: The change of P50 could be a feature of the adaptation to the plateau and to avoid altitude sickness, such as high-altitude polycythemia and dyspnea. PMID: 29130390 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 14, 2017 Category: Hematology Tags: Hematology Source Type: research

Corrigendum.
Authors: PMID: 29130398 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 14, 2017 Category: Hematology Tags: Hematology Source Type: research

Corrigendum.
Authors: PMID: 29115182 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 10, 2017 Category: Hematology Tags: Hematology Source Type: research

Identification of a de novo ANK1 mutation in a Chinese family with hereditary spherocytosis.
DISCUSSION: Our finding suggested that a de novo nonsense mutation in ANK1 may be causative to HS which plays an important role in supplementing the mutational spectrum of the ANK1 and explaining the mechanism of HS. Our study also indicated that WES can be an effective and accurate diagnostic tool in the discovery of causative mutations in genetic heterogeneous Mendelian disorders. PMID: 29099659 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 4, 2017 Category: Hematology Tags: Hematology Source Type: research

Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies.
CONCLUSION: Our results suggest that both preterm and postterm infants have an elevated risk of developing AML. In addition, postterm birth increased the risk of childhood leukemia and ALL in cohort studies. However, more studies are warranted to validate these results and explore the biologic mechanisms underlying these relationships. PMID: 29099685 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 4, 2017 Category: Hematology Tags: Hematology Source Type: research

Involvement of oncogenic tyrosine kinase NPM-ALK in trifluoperazine-induced cell cycle arrest and apoptosis in ALK(+) anaplastic large cell lymphoma.
CONCLUSIONS: Our results demonstrate for the first time that TFP is capable of inducing degradation and inhibition of kinase activity of NPM-ALK, as well as the increased level of phospho-NPM-ALK, leading to the inhibition of cell growth in ALK(+) ALCL cells. TFP may have a potential to be utilized to treat this aggressive lymphoma. PMID: 29086626 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - November 1, 2017 Category: Hematology Tags: Hematology Source Type: research

Elevated plasma asymmetric dimethylarginine levels in children with beta-thalassemia major may be an early marker for endothelial dysfunction.
In this study, we aimed to investigate circulating ADMA concentrations in children with beta-thalassemia major. METHODS: Thirty-one beta-thalassemia major children aged between 4 and 16 year old and age, gender-matched 36 healthy controls were enrolled in the study. Plasma ADMA was measured along with the soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), P-selectin, and Pentraxin-3. RESULTS: Age, gender and body mass index were similar in two groups. Plasma ADMA, sVCAM-1, and sICAM-1 measurements were significantly higher in beta-thalassemia major pa...
Source: Hematology - November 1, 2017 Category: Hematology Tags: Hematology Source Type: research

Anthropometric measurements in children having transfusion-dependent beta thalassemia.
Authors: Moiz B, Habib A, Sawani S, Raheem A, Hasan B, Gangwani M Abstract OBJECTIVES: The aim of this study was to determine the anthropometric measurements in transfusion-dependent β-thalassemia children in Pakistan. The secondary aim was to correlate serum ferritin with the physical growth. METHODS: We enrolled 367 children (aged 5-17 years) with transfusion-dependent beta-thalassemia major in the study. Anthropometric measurements, serum ferritin levels, and pre-transfusion hemoglobin levels were measured. Serum ferritin was correlated with the height z-score for age. RESULTS: Laboratory evaluation...
Source: Hematology - November 1, 2017 Category: Hematology Tags: Hematology Source Type: research

Impact of estimated glomerular filtration rate based on plasma cystatin C and serum creatinine levels before allogeneic hematopoietic cell transplantation.
Authors: Wada H, Kanda J, Akahoshi Y, Nakano H, Ugai T, Yamasaki R, Ishihara Y, Kawamura K, Sakamoto K, Ashizawa M, Sato M, Terasako-Saito K, Kimura SI, Kikuchi M, Nakasone H, Yamazaki R, Kako S, Tanihara A, Nishida J, Kanda Y Abstract BACKGROUND: No standard method for measuring renal function has been established in allogeneic hematopoietic cell transplantation (allo-HCT). METHODS: We retrospectively analyzed 80 patients with hematological diseases who underwent allo-HCT at our center. We assessed renal function using creatinine clearance (Ccr), estimated glomerular filtration rate (eGFR) based on creatinine ...
Source: Hematology - November 1, 2017 Category: Hematology Tags: Hematology Source Type: research

Serum ferritin is a different predictor from transfusion history for allogeneic transplantation outcome in patients with severe aplastic anemia.
Authors: Zhang X, Shi Y, Huang Y, Zhang G, He Y, Jiang E, Wei J, Yang D, Ma Q, Zhang R, Zhai W, Feng S, Han M Abstract OBJECTIVES: Severe aplastic anemia (SAA) patients receive more red blood cell (RBC) transfusions as supportive management. We aim to clarify the associations between transfusion history or pre-transplantation serum ferritin (SF) and the overall survival of allogeneic hematopoietic stem cell transplantation (allo-HSCT) among SAA patients. MATERIAL AND METHODS: We retrospectively investigated 96 SAA patients undergoing allo-HSCT, and grouped them according to pre-transplantation duration. Pre-tra...
Source: Hematology - October 21, 2017 Category: Hematology Tags: Hematology Source Type: research

Estrogen receptor beta expression and prognosis of diffuse large B cell lymphoma.
CONCLUSION: ERβ1 protein expression represented opposite prognostic factors in nodal vs. extra-nodal DLBCL. PMID: 29032728 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - October 18, 2017 Category: Hematology Tags: Hematology Source Type: research

Tolerability and safety of the intravenous immunoglobulin octagam( ®) 10% in patients with immune thrombocytopenia: a post-authorisation safety analysis of two non-interventional phase IV trials.
CONCLUSIONS: Routine clinical use of octagam(®) 10% was safe and well tolerated, with no unexpected safety issues, in patients with ITP. The two studies from which data were taken are registered with the International Standard Randomised Controlled Trial Number Registry, numbers ISRCTN58800347 and ISRCTN02245668. PMID: 29020871 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - October 14, 2017 Category: Hematology Tags: Hematology Source Type: research

Knockdown of REG γ inhibits the proliferation and migration and promotes the apoptosis of multiple myeloma cells by downregulating NF-κB signal pathway.
This study aimed to evaluate the effects of REGγ knockdown on the proliferation, apoptosis and migration of multiple myeloma (MM) cells, and reveal the potential regulatory mechanisms. METHODS: The expression of REGγ on myeloma cells of 28 MM patients was detected by Western blot. shRNA-REGγ-1 and shRNA-REGγ-2 were constructed to downregulate REGγ in RPMI-8226 cells. The proliferation, apoptosis and migration of transfected cells were analyzed by Cell Counting Kit 8 (CCK8), flow cytometry and transwell chamber, respectively. The expression of phosphorylated p65 (p-p65), p65, NF-kappa-B inh...
Source: Hematology - October 14, 2017 Category: Hematology Tags: Hematology Source Type: research

The potential association of tumor necrosis factor- βeta (252 G/A) cytokine gene polymorphism with immune thrombocytopenic purpura among Egyptian children.
CONCLUSION: The risk of developing ITP was not related to the studied polymorphism. PMID: 29020887 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - October 14, 2017 Category: Hematology Tags: Hematology Source Type: research

Recommendations on the use of ruxolitinib for the treatment of myelofibrosis.
CONCLUSION: With the aim to optimize the treatment of MF patients, the Belgian regulation for ruxolitinib should be revised in terms of reimbursement criteria, dose titration, stopping rules, and patient follow-up. PMID: 29022420 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - October 14, 2017 Category: Hematology Tags: Hematology Source Type: research