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Innovative PCR without DNA extraction for African sickle cell disease diagnosis.
In this study, we tested the performance of a new molecular diagnostic tests on qualified samples. METHODS: The Human Hb S/C Lamp assay is a new polymerase chain reaction test able to detect HbS, HbC and HbA alleles without DNA extraction, directly on fresh or frozen blood samples, or on dried blood spots (DBS). In this study, we compared the genotyping of 248 blood samples (56 whole blood and 192 DBS) with this LAMP assay to the routine diagnostic methods performed in the genetics lab at the university hospital of Liège. RESULTS: Our results show that the LAMP method can detect HbS and HbC with an accuracy ...
Source: Hematology - September 21, 2017 Category: Hematology Tags: Hematology Source Type: research

Flow cytometric analysis of patients with hereditary spherocytosis - an Indian scenario.
This study was conducted to evaluate the utility of FC-OFT in all newly diagnosed cases of HS, to compare its diagnostic value with conventional OFT and to correlate with clinical disease severity. METHODS: In this study, the percentage of residual red cells (%RRC) was measured using flow cytometer after creating a red cell suspension. Subsequently, this was spiked with deionized water for FC-OFT in all cases of HS (n = 40), healthy subjects (n = 40) and beta-thalassemia traits (BTT) (n = 20). RESULTS: The receiver operator curve analysis defined the optimal cut-offs for FC...
Source: Hematology - September 17, 2017 Category: Hematology Tags: Hematology Source Type: research

Associations between the HLA-A/B/DRB1 polymorphisms and aplastic anemia: evidence from 17 case-control studies.
CONCLUSION: In conclusion, HLA-A/B/DRB1 polymorphisms may play an important role in AA, but higher quality and larger sample studies are needed to confirm. PMID: 28902578 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - September 15, 2017 Category: Hematology Tags: Hematology Source Type: research

High absolute basophil count is a powerful independent predictor of inferior overall survival in patients with primary myelofibrosis.
Authors: Lucijanic M, Livun A, Stoos-Veic T, Pejsa V, Jaksic O, Cicic D, Lucijanic J, Romic Z, Orehovec B, Aralica G, Miletic M, Kusec R Abstract OBJECTIVES: To investigate the clinical and prognostic significance of absolute basophil count (ABC) in patients with primary myelofibrosis (PMF). METHODS: We retrospectively investigated 58 patients with PMF treated in our institution in the period from 2006 to 2017. ABC was obtained in addition to other hematological and clinical parameters. Patients were separated into high and low ABC groups using the Receiver operating characteristic curve analysis. RESULTS: ...
Source: Hematology - September 15, 2017 Category: Hematology Tags: Hematology Source Type: research

Sex chromosome changes in leukemia: cytogenetics and molecular aspects.
CONCLUSION: The presence of these abnormalities can cause genetic instability in BM and result in the development of a malignant clone and progression of the disease. In addition, the evaluation of SCL together with the genes involved in these chromosomes can contribute to predict the disease prognosis as well as monitoring of malignancy. PMID: 28889783 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - September 12, 2017 Category: Hematology Tags: Hematology Source Type: research

The impact of FLT3 mutations on treatment response and survival in Chinese de  novo AML patients.
This study was aimed to analyze the impacts of these mutations on clinical outcomes, and assess the efficacy of different therapeutic regimens (allo-HSCT, sorafenib, or conventional chemotherapy) for AML patients with FLT3 mutations after the standard induction therapy. MATERIALS AND METHODS: We analyzed DNA samples from 158 consecutive de novo AML patients (18-60 years, excluding APL) with FLT3 mutations between July 2010 and October 2015. RESULTS: We found that AML patients with FLT3-TKD mutations have more favorable clinical outcomes than those with FLT3-ITD mutations. We also found that allo-HSCT therapy subgro...
Source: Hematology - September 8, 2017 Category: Hematology Tags: Hematology Source Type: research

Decreased levels of Th17 cells are associated with invasion fungal infections after allogeneic hematopoietic stem cell transplantation.
CONCLUSIONS: These findings supported that Th17 cells may be involved in the immune pathology of IFIs after allo-HSCT. PMID: 28880742 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - September 8, 2017 Category: Hematology Tags: Hematology Source Type: research

The impact of Fc gamma receptor IIa and IIIa gene polymorphisms on the therapeutic response of rituximab in Egyptian adult immune thrombocytopenic purpura.
CONCLUSION: The higher platelet count achieved early is predictive for a better response to rituximab later. FCγRIIA polymorphisms did not significantly influence response to rituximab in ITP. PMID: 28856973 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - September 1, 2017 Category: Hematology Tags: Hematology Source Type: research

Challenges in the management of sickle cell disease during pregnancy in Senegal, West Africa.
Authors: Faye BF, Kouame KB, Seck M, Diouf AA, Gadji M, Dieng N, Touré SA, Sall A, Toure AO, Diop S Abstract OBJECTIVES: The aim of this study was to evaluate the maternal and fetal complications in pregnant patients with sickle cell disease (SCD) and find risk factors of stillbirth. METHOD: We conducted a prospective study in pregnant women with SCD. Demographic characteristics, maternal and fetal morbi-mortality, and outcome of pregnancies were described. Risk factors of fetal loss were evaluated by comparing the parameters of the pregnancies that led to a live birth with those interrupted. RESULTS...
Source: Hematology - August 29, 2017 Category: Hematology Tags: Hematology Source Type: research

Human platelet antigen 1, 2 and 5 gene polymorphisms in Egyptians and their potential association with susceptibility to immune thrombocytopenic purpura in Egyptian patients.
CONCLUSION: HPA 2b are 2.37 times more likely to develop ITP compared to those without this allele. The relatively high allele frequency of the HPA-1b in the Egyptian population suggests that this ethnic group has a higher risk of alloimmunization. PMID: 28823219 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 22, 2017 Category: Hematology Tags: Hematology Source Type: research

Can biomarkers of coagulation, platelet activation, and inflammation predict mortality in patients with hematological malignancies?
This study is a prospective observational cohort study; Hypercoagulability and inflammatory biomarkers including:(1) Coagulation and fibrinolysis activation Markers (D-dimer, Fibrinogen, Antithrombin, plasminogen activator inhibitor 1 [PAI-1]);(2) Endothelium and platelet activation Markers (von Willebrand Factor [vWF], soluble P-selectin); and (3) Inflammation Markers (Tumor necrosis factor alpha [TNF-α], Interleukin-6 [IL-6]) were assayed on a group of 171 patients with hematological malignancies at time of diagnosis. They have been followed up for an average period of 416.8 days with an endpoint of mortality. ...
Source: Hematology - August 22, 2017 Category: Hematology Tags: Hematology Source Type: research

Double vs. single cord blood transplantation in adolescent and adult hematological malignancies with heavier body weight ( ≥50 kg).
CONCLUSIONS: For adolescent and adult hematological malignancies with heavier body weight (≥50kg), double-unit CBT has an inferior clinical outcome when compared with single-unit CBT having a sufficient cell dose. Double-unit CBT should only reserve for patients who need an urgent transplant but lacking of a related or unrelated donor and without an adequately dosed single CB. PMID: 28795658 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 12, 2017 Category: Hematology Tags: Hematology Source Type: research

Interaction between Hb E and Hb Yala (HBB:c.129delT); a novel frameshift beta globin gene mutation, resulting in Hemoglobin E/ β(0) thalassemia.
CONCLUSION: This report has provided evidence that genotype-phenotype correlation in thalassemia syndromes is highly complex and a correct clinical severity classification of thalassemia should be mainly based on clinical evaluation. PMID: 28768465 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 6, 2017 Category: Hematology Tags: Hematology Source Type: research

Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD.
CONCLUSIONS: Assessment of T-cell differentiation stages in malignant T lymphoblasts would be important in choosing treatment strategies for adult patients with T-LBL. PMID: 28778131 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 6, 2017 Category: Hematology Tags: Hematology Source Type: research

Stigma and illness uncertainty: adding to the burden of sickle cell disease.
CONCLUSION: The study highlights socioeconomic factors to be significant to the stigma and illness uncertainty experiences in SCD. Efforts by healthcare workers to reduce patient illness uncertainty may have additional impact, reducing their stigma. PMID: 28766464 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 3, 2017 Category: Hematology Tags: Hematology Source Type: research

Epidemiologic study of major complications in adolescent and adult patients with thalassemia in Northeastern Thailand: the E-SAAN study phase I.
CONCLUSION: Nearly half of the patients in this cohort had disease-related complications. Splenectomy and advanced age were important factors for complication involvement. Early screening for the complications may reduce the morbidity and mortality in patients with thalassemia. PMID: 28759343 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 2, 2017 Category: Hematology Tags: Hematology Source Type: research

Congenital prothrombin defects: they are not only associated with bleeding but also with thrombosis: a new classification is needed.
CONCLUSIONS: These observations have required a reclassification of prothrombin defects. To the Type I and Type II defects, a Type III has to be added characterized by the absence of bleeding and the presence of venous thrombosis. It is not clear yet if this special variant of Type II defect is limited to the Arg596 mutations or if other residues may be involved. PMID: 28762299 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 2, 2017 Category: Hematology Tags: Hematology Source Type: research

Microsatellite Instability and Promoter Hypermethylation of DNA repair genes in Hematologic Malignancies: a forthcoming direction toward diagnostics.
CONCLUSION: The presence of specific microsatellite marker hyper-mutability and consistent promoter hypermethylation in leukemia or lymphoma can be considered as a part of routine diagnostic test in clinical laboratories. PMID: 28728506 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 23, 2017 Category: Hematology Tags: Hematology Source Type: research

Thalidomide has a significant effect in patients with thalassemia intermedia.
CONCLUSION: Thalidomide had a significant effect in patients with thalassemia intermedia. Further studies of a larger scale and more rigorous design are warranted. PMID: 28718348 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 20, 2017 Category: Hematology Tags: Hematology Source Type: research

Characteristics of bone marrow cell dysplasia and its effectiveness in diagnosing myelodysplastic syndrome.
CONCLUSION: Four specific dysplastic types possess higher diagnostic efficacy for the diagnosis of MDS. Though the dysplastic rate over 10% in any hematopoietic cell lineage presents a lower FPR, it is possibly considered to lower the diagnostic threshold of MDS if a specific dysplastic type with higher diagnostic efficacy presents. PMID: 28675126 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 6, 2017 Category: Hematology Tags: Hematology Source Type: research

Pretransplant serum FT3 levels in recipients predict early non-relapse mortality after myeloablative allogeneic haematopoietic cell transplantation from matched sibling donors.
CONCLUSION: A low FT3 level before conditioning may be a useful predictive biomarker for higher early NRM among patients undergoing myeloablative sibling transplantation. PMID: 28651453 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 29, 2017 Category: Hematology Tags: Hematology Source Type: research

Neurocognitive dysfunction in children with β thalassemia major: psychometric, neurophysiologic and radiologic evaluation.
CONCLUSION: β-TM is associated with neurocognitive impairment that can be assessed by psychometric, neurophysiologic and radiologic tests. The role of hemosiderosis and iron chelation therapy on cognitive functioning still need more research. ABBREVIATIONS: β-TM: beta thalassemia major; DFO: Dysferal; DFP: Deferiprone; DFX: Deferasirox; WISC: Wechsler Intelligence Scale for Children; VIQ: verbal IQ; PIQ: performance IQ; TIQ: total IQ; BVRT: Benton Visual Retention Test; WCST: Wisconsin Card Sort Test; MRS: Magnetic resonant spectroscopy; NAA/Cr ratio: N-acetylaspartate to creatine ratio. PMID: 28621205 [P...
Source: Hematology - June 19, 2017 Category: Hematology Tags: Hematology Source Type: research

Revisiting beta thalassemia intermedia: past, present, and future prospects.
CONCLUSION: TI is not a mild disease. The interplay of three hallmark pathophysiologic factors (ineffective erythropoiesis, chronic anemia, and iron overload) leads to the clinical presentations seen in TI. New treatment modalities are currently being investigated to broaden the options available for TI management. PMID: 28589785 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 9, 2017 Category: Hematology Tags: Hematology Source Type: research

Safety and efficacy of Ofatumumab in chronic lymphocytic leukemia: a systematic review and meta-analysis.
DISCUSSION: Our analysis showed PFS was statistically significantly improved with Ofatumumab-based treatments (including Ofatumumab alone, Ofatumumab plus chemotherapy) for CLL compared with observation or chemotherapy-based regimen groups. Ofatumumab had no statistically significant improvement on the OS of patients with CLL. The Ofatumumab-based therapy could generally decrease the risk of adverse effects except infusion-related reaction and infections. PMID: 28580841 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 7, 2017 Category: Hematology Tags: Hematology Source Type: research

Relapse of childhood acute lymphoblastic leukemia and outcomes at a reference center in Latin America: organomegaly at diagnosis is a significant clinical predictor.
CONCLUSION: A high rate of very early, CNS, and BM relapse with a considerably low 5-year OS requiring reassessment of therapy was documented. Organomegaly at diagnosis was a highly significant clinical predictor for relapse. PMID: 28580844 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 7, 2017 Category: Hematology Tags: Hematology Source Type: research

Interferon- γ mediates the immunosuppression of bone marrow mesenchymal stem cells on T-lymphocytes in vitro.
CONCLUSIONS: Human MSCs constitutively expressed immunosuppressive levels of PGE2, HGF and TGF-β1. The proinflammatory cytokine IFN-γ exhibited synergistic effects with MSCs on immunosuppression, possibly by up-regulating PGE2, HGF and TGF-β1 in MSCs and inducting MSCs expression of IDO, involved in tryptophan catabolism. PMID: 28581352 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 7, 2017 Category: Hematology Tags: Hematology Source Type: research

Positron emission tomography computed tomography features of monomorphic epitheliotropic intestinal T-cell lymphoma.
CONCLUSION: These findings showed that in contrast to classical enteropathy-associated T-cell lymphoma, where the small bowel is the exclusive primary site (owing to its origin from coeliac disease) and distant metastases even during relapse are exceptional, MEITL might on presentation and during relapse involve any part of the gut, and metastasize to multiple extra-intestinal sites. PMID: 28581364 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 7, 2017 Category: Hematology Tags: Hematology Source Type: research

Monoclonal B-cell lymphocytosis in blood donors in Turkey.
CONCLUSION: Large population-based studies and standardized laboratory methods are needed to determine the potential risk factors of progression to CLL, including molecular markers and genetic profile. PMID: 28583051 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 7, 2017 Category: Hematology Tags: Hematology Source Type: research

The role of bone marrow microenvironment in platelet production and their implications for the treatment of thrombocytopenic diseases.
CONCLUSIONS: Further definition of the role of bone marrow microenvironment in platelet generation may deepen our understanding of the underlying mechanisms as well as provide new therapeutic targets for thrombocytopenic diseases. PMID: 28569613 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 3, 2017 Category: Hematology Tags: Hematology Source Type: research

Clinical characteristics, molecular profile and outcomes of myeloid sarcoma: a single institution experience over 13 years.
Authors: Kaur V, Swami A, Alapat D, Abdallah AO, Motwani P, Hutchins LF, Jethava Y Abstract BACKGROUND: Myeloid sarcoma (MS) is characterized by extramedullary infiltration by immature myeloid cells. Owing to rarity of this disease, the clinical features and overall outcomes are yet to be clarified. OBJECTIVE: To define clinical characteristics, epidemiology, pathologic findings, treatment options and outcomes in MS. METHODS: We conducted a retrospective review of 23 patients diagnosed with MS at our institute over a period of 13 years (2002-2015). RESULTS: MS presented mostly as a manifestation of rela...
Source: Hematology - June 3, 2017 Category: Hematology Tags: Hematology Source Type: research

Cardiovascular events during carfilzomib therapy for relapsed myeloma: practical management aspects from two case studies.
CONCLUSION: Carfilzomib has a favorable benefit-risk profile in MM; adopting proactive practices can assist in the prevention, early detection, and management of carfilzomib-associated cardiovascular events, which may allow for continuation of therapy with this effective agent. PMID: 28545322 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 28, 2017 Category: Hematology Tags: Hematology Source Type: research

Pre-transplantation thymic function is associated with the risk of acute graft versus host disease and cytomegalovirus viremia after allogeneic hematopoietic stem cell transplantation.
Authors: Yang X, Sun Y, Zhang S, Yang H, Wei J, He Y, Yang D, Jiang E, Han M, Qin X, Feng S Abstract OBJECTIVES: To analyze the kinetics of T-cell subsets and thymic function reconstitution after allogeneic hematopoietic stem cell transplantation (AHSCT); to determine whether sjTREC (signal joint TCR rearrangement excision circle) and CD31-positive recent thymic emigrant (CD31 + RTE) are correlated with acute graft versus host disease (aGVHD) or CMV (cytomegalovirus) viremia after AHSCT. METHODS: Forty-nine patients who underwent AHSCT in our institution were prospectively enrolled. Periphery bloo...
Source: Hematology - May 24, 2017 Category: Hematology Tags: Hematology Source Type: research

Kidney injury in infants and children with iron-deficiency anemia before and after iron treatment.
CONCLUSION: Subclinical kidney injury was found in infants and children with IDA. This injury was completely reversible in older children with IDA and partially reversible in infants with IDA after iron therapy. Higher urinary levels of kidney injury molecules in IDA infants after iron treatment are suggestive of more sensitivity of these infants to oxidative stress caused by iron therapy or may be due to the immaturity of the kidney and more damage caused by IDA which may require more time to recover. PMID: 28506129 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 20, 2017 Category: Hematology Tags: Hematology Source Type: research

Combined chemotherapy for acute promyelocytic leukemia: a meta-analysis.
CONCLUSION: Combined chemotherapy for APL is associated with 90% CR, 14.4% relapse rate, 86% 5-year OS, and 75% 5-year DFS. Induction with ATRA-DNR-ATO is found better than other combinations with respect to CR and relapse rates. Initial leukocyte count may affect prognosis. PMID: 28480800 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 11, 2017 Category: Hematology Tags: Hematology Source Type: research

Hepatitis B reactivation in patients receiving targeted therapies.
CONCLUSION: HBV reactivation may occur in patients receiving monoclonal antibodies and TKIs, even with resolved HBV infection status. Although the exact mechanism of TKI-induced HBV reactivation remains unclear, off-target immunological effects of TKI may play an important role in contributing to HBV reactivation. PMID: 28485688 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 11, 2017 Category: Hematology Tags: Hematology Source Type: research

Analysis of clinical characteristics and prognostic factors of multiple myeloma: a retrospective single-center study of 787 cases.
CONCLUSION: The MM patients in China are relatively younger, have higher rate on stage III according to D-S system. Older age, high serum calcium, high LDH, high percentage of abnormal plasma cells in bone marrow were highly related to poor prognosis. PMID: 28463078 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 5, 2017 Category: Hematology Tags: Hematology Source Type: research

The effects of a data driven maximum surgical blood ordering schedule on preoperative blood ordering practices.
This study compared blood ordering and utilization during the period when the MSBOS was created by achieving consensus between the blood bank and the various surgical specialties, and after the introduction of an MSBOS created by using department-specific red blood cell (RBC) transfusion data (data driven MSBOS, dMSBOS). METHODS: The dMSBOS was created by analyzing 12 months of RBC transfusion data for each procedure across a regional health system. Pre-transfusion testing and the RBC crossmatch:transfusion (C:T) ratios at 8 of the hospitals were compared between the 12 month period before the dMSBOS was introduced, an...
Source: Hematology - April 28, 2017 Category: Hematology Tags: Hematology Source Type: research

Acquired hemophilia A: a review of recent data and new therapeutic options.
CONCLUSION: The optimal management of AHA should be multidisciplinary and requires a close collaboration between physicians from various specialties. PMID: 28441921 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 28, 2017 Category: Hematology Tags: Hematology Source Type: research

A child with severe iron-deficiency anemia and a complex TMPRSS6 genotype.
CONCLUSION: The proband was symptomatic for IRIDA during a critical phase of growth and development, but we did not find a clearly causative genotype. A long-term result, improving stably patient's Hb levels, was obtained only after liposomal iron supplementation. Children may be at greater risk for iron deficiency and the degree of anemia as well as the response to the iron supplements varies markedly patient to patient. Here, we show the importance of comprehensive study of these patients in order to collect useful information about genotype-phenotype association of genes involved in iron metabolism. PMID: 28447549 [...
Source: Hematology - April 28, 2017 Category: Hematology Tags: Hematology Source Type: research

Characteristics and management of primary and other immune thrombocytopenias: Spanish registry study.
CONCLUSIONS: Characteristics of Spanish ITP patients are comparable to those from other countries. Although a high response rate to first-line treatments is observed, at 1 year, the disease persists in around one quarter of patients. Overall therapeutic management in Spain conforms to current recommendations, except for an excessive duration of corticosteroids therapy. PMID: 28415913 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 20, 2017 Category: Hematology Tags: Hematology Source Type: research

Elevation of CD16(+)CD56(+) NK-cells and down-regulation of serum interleukin-21 (IL-21) and IL-1 α after splenectomy in relapsed hemophagocytic lymphohistiocytosis of unknown cause.
Elevation of CD16(+)CD56(+) NK-cells and down-regulation of serum interleukin-21 (IL-21) and IL-1α after splenectomy in relapsed hemophagocytic lymphohistiocytosis of unknown cause. Hematology. 2017 Apr 15;:1-7 Authors: Wang J, Han W, Gao Z, Wang Y, Wu L, Zhang J, Lai W, Wang Z Abstract OBJECTIVES: Encouraging progress has been made in application of splenectomy in the treatment of relapsed hemophagocytic lymphohistiocytosis (HLH) of unknown cause. The aim was to determine the roles of lymphocyte subpopulations and inflammatory cytokines in splenectomy. METHODS: We retrospectively analyzed ch...
Source: Hematology - April 18, 2017 Category: Hematology Tags: Hematology Source Type: research

Prognostic value of the soluble interleukin-2 receptor level after patients with follicular lymphoma achieve a response to R-CHOP.
Authors: Umino K, Fujiwara SI, Ikeda T, Toda Y, Ito S, Mashima K, Minakata D, Nakano H, Yamasaki R, Kawasaki Y, Sugimoto M, Yamamoto C, Ashizawa M, Hatano K, Sato K, Oh I, Ohmine K, Muroi K, Kanda Y Abstract OBJECTIVES: Follicular lymphoma (FL) is a clinically and biologically heterogeneous disease. Therefore, it is important to identify factors that can predict its clinical outcome. METHODS: We retrospectively evaluated the usefulness of soluble interleukin-2 receptor (sIL-2R) levels after R-CHOP (posttreatment sIL-2R) in 72 patients with newly diagnosed FL who had either a complete response (CR) or partial re...
Source: Hematology - April 18, 2017 Category: Hematology Tags: Hematology Source Type: research

Clinical and hematological relevance of JAK2 V617F and CALR mutations in BCR-ABL-negative ET patients.
CONCLUSION: We reported the frequency of JAK2 V617F, MPL W515L/K, and CALR mutations in Thai patients with ET. Clinical and hematological phenotypes of patients were associated with JAK2 and CALR mutation statuses. The combination of laboratory testing for the detection of JAK2, CALR, and MPL mutations is necessary to improve the diagnosis and classification of BCR-ABL1-negative MPN. PMID: 28406068 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 15, 2017 Category: Hematology Tags: Hematology Source Type: research

Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with β-thalassemia.
CONCLUSION: Speckle tracking echocardiography could be used as a feasible method for evaluating subclinical myocardial dysfunction in patients with thalassemia major. Echocardiography, using GLS, could predict clinically silent myocardial dysfunction independent of CMR (T2 * value) and extension of iron deposition. Our study also puts forward other causes such as chronic tissue hypoxia resulting from chronic anemia as a root cause and initiating factor for subsequent injury by the iron deposition. Speckle tracking can recognize the cardiac involvement in really early stages. PMID: 28399703 [PubMed - as supplied by publ...
Source: Hematology - April 14, 2017 Category: Hematology Tags: Hematology Source Type: research

Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
CONCLUSION AND DISCUSSION: Our data support a role for ADAM12 in NHL cell proliferation, adhesion, and drug resistance, and it may pave the way for a novel therapeutic approach for CAM-DR in NHL. PMID: 28395594 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 12, 2017 Category: Hematology Tags: Hematology Source Type: research

Clinical usefulness of FDG-PET/CT for the evaluation of various types of adult T-cell leukemia.
CONCLUSION: FDG-PET/CT findings could be useful for clinically grading ATL. PMID: 28397608 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 12, 2017 Category: Hematology Tags: Hematology Source Type: research

Transforming growth factor 15 increased in severe aplastic anemia patients.
In this study, we investigated the level of GDF-15 and other indexes of iron metabolism in SAA patients to explore the correlation with GDF-15 and iron overload in SAA. METHODS: The levels of serum GDF-15, hepcidin (Hepc), and erythropoietin (EPO) were determined by ELISA. The levels of serum iron (SI), ferritin, TIBC, and transferrin saturation (TS) were measured by an auto analyzer. Iron staining of bone marrow cells was used for testing extracellular and intracellular iron. RESULTS: The GDF-15 level in the experimental group was higher than that of the case-control group and normal control group (all p 
Source: Hematology - April 8, 2017 Category: Hematology Tags: Hematology Source Type: research

Predictive parameters for imatinib failure in patients with chronic myeloid leukemia.
Authors: Lekovic D, Gotic M, Milic N, Zivojinovic B, Jovanovic J, Colovic N, Milosevic V, Bogdanovic A Abstract OBJECTIVE: Until recently, imatinib was the standard first-line treatment in chronic myeloid leukemia (CML). The inclusion of nilotinib and dasatinib as first-line options in CML raised a debate on treatment selection. The aim of our study was to analyze predictive parameters for imatinib response as the first-line treatment of CML patients. METHODS: The study included 168 consecutive patients with chronic phase Philadelphia-positive CML who were diagnosed and treated with Imatinib 400 mg once daily...
Source: Hematology - March 23, 2017 Category: Hematology Tags: Hematology Source Type: research

ADAMTSL5 and CDH11: putative epigenetic markers for therapeutic resistance in acute lymphoblastic leukemia.
Authors: Abdullah M, Choo CW, Alias H, Abdul Rahman EJ, Ibrahim HM, Jamal R, Hussin NH Abstract BACKGROUND AND OBJECTIVES: DNA hypermethylation has been linked to poor treatment outcome in childhood acute lymphoblastic leukemia (ALL). Genes differentially methylated in the chemoresponsive pre-B-ALL compared to chemoresistant pre-B-ALL cases provide potential prognostic markers. METHODS: DNA methylation profiles of five B-ALL childhood patients who achieved morphological complete remission (chemoresponsive) and five B-ALL patients who did not (chemoresistant) after induction treatments as well as four normal con...
Source: Hematology - March 18, 2017 Category: Hematology Tags: Hematology Source Type: research

Assessment of Th17/Treg cells and Th cytokines in an improved immune thrombocytopenia mouse model.
CONCLUSION: Our data suggest that the improved passive ITP mouse model does not mimic the autoimmune inflammatory process of human ITP. Compared with human ITP, this model has a similar change in frequency of Treg cells, which may directly or indirectly result from antibody-mediated platelet destruction due to attenuated release of TGF-β. PMID: 28300523 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 18, 2017 Category: Hematology Tags: Hematology Source Type: research