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The clinical characteristics and therapy response of patients with acquired pure red cell aplasia.
Authors: Fu R, Zhang T, Liu B, Song J, Wang G, Li L, Wang H, Xing L, Wu Y, Guan J, Shao Z Abstract OBJECTIVE: To summarize the clinical characteristics of acquired pure red cell aplasia (PRCA) patients diagnosed in our hospital in the last 10 years. METHOD: The clinical features, immune state and treatment response of acquired PRCA patients diagnosed in our hospital from January 2007 to January 2017 were retrospectively analyzed. RESULTS: The results showed that thymoma (13.21%) and parvovirus B19 (11.32%) were the most common causes for secondary PRCA. Ferritin (Fer) levels and erythropoietin (EPO) levels ...
Source: Hematology - May 16, 2018 Category: Hematology Tags: Hematology Source Type: research

Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis.
CONCLUSION: In conclusion, SRSF2 mutations were significantly related to the shorter OS in patients with MDS which may consider as an adverse prognostic risk factor. Whereas, analysis did not show any prognostic effect on OS of CMML patients with SRSF2 mutations. PMID: 29757120 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 16, 2018 Category: Hematology Tags: Hematology Source Type: research

Characteristics of fibrinolytic disorders in acute promyelocytic leukemia.
CONCLUSIONS: In APL, activated coagulation system activated fibrinolytic system, and increased uPAR levels could contribute to the hyperfibrinolysis. Annexin II might not be involved in the coagulopathy. PMID: 29724147 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study.
CONCLUSION: A high prevalence of iron overload in this patient population in Latin American countries indicates that a better diagnosis and management of iron overload is required in these countries. PMID: 29663858 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Geographical distribution of β-globin gene mutations in Syria.
Conclusions These data will significantly facilitate the population screening, genetic counseling and prenatal diagnosis in Syrian population. PMID: 29637841 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 14, 2018 Category: Hematology Tags: Hematology Source Type: research

Iron deficiency anemia referral to the hematologist. Real-world data from Mexico: the need for targeted teaching in primary care.
Authors: López-García YK, Colunga-Pedraza PR, Tarín-Arzaga L, López Garza MI, Jaime-Pérez JC, Gómez-Almaguer D Abstract OBJECTIVES: To determine the referral patterns and etiology of iron deficiency anemia (IDA) at an academic hematology center in northeast Mexico. METHODS: We included all consecutive outpatients older than 16 years, non-pregnant, with IDA diagnosed in the Hematology Service of the Dr. José E. González University Hospital between January 2012 and May 2017. Appropriate data were collected retrospectively from the electronic medical rec...
Source: Hematology - April 14, 2018 Category: Hematology Tags: Hematology Source Type: research

Mean platelet volume at baseline and immune thrombocytopenia relapse in Chinese newly-diagnosed patients: a retrospective cohort study.
Conclusion The relationship between MPV and ITP relapse is non-linear. MPV is an independent risk factor of ITP relapse when MPV is less than 21 fl. PMID: 29633664 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 12, 2018 Category: Hematology Tags: Hematology Source Type: research

Contrasting co-inheritance of alpha and beta mutations in delta beta thalassemia and hereditary persistence of fetal hemoglobin: a study from India.
CONCLUSION: We found 5/18(27.β) δβ-thalassemia cases with co-inherited alpha 3.7 deletion and 3/18 (16β) cases with IVS 1-5(G-C) mutation. Patients showed features of thalassemia intermedia phenotype among which those with co-inherited IVS 1-5(G-C) mutation showed severe phenotype as compared to those with co-inherited alpha 3.7 deletion. So, we highlight importance of genotyping of patients with δβ thalassemia or HPFH and coinheritance with inherited factors which plays crucial role in clinicopathological profile and setting up prenatal diagnostic protocol. PMID: 29621931 [PubMed - as s...
Source: Hematology - April 7, 2018 Category: Hematology Tags: Hematology Source Type: research

Analysis of erythrocyte membrane proteins in patients with hereditary spherocytosis and other types of haemolytic anaemia.
CONCLUSION: Haemolysis in patients with HS occurred because the fragile proteins in erythrocytes (band 3, spectrin, and ankyrin) collapsed due to compression during blood circulation in the spleen. Further, haemolysis in patients with haemoglobinopathy occurred owing to membrane damage due to combined spectrin, band 3 with denatured haemoglobin in the vessel during blood circulation. PMID: 29623813 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 7, 2018 Category: Hematology Tags: Hematology Source Type: research

Humoral immune response of childhood acute lymphoblastic leukemia survivors against the measles, mumps, and rubella vaccination.
CONCLUSION: We suggest the need for booster MMR vaccination, especially for ALL children under the age of 5 years and those who experienced a protracted time interval post-treatment. PMID: 29614919 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 6, 2018 Category: Hematology Tags: Hematology Source Type: research

Sequence typing of human adenoviruses isolated from Polish patients subjected to allogeneic hematopoietic stem cell transplantation - a single center experience.
CONCLUSIONS: The predominance of HAdV-C and common presence of anti-HAdV antibodies in IgG class may strongly suggest that most infections in the present study were reactivations of HAdV persisting into the patient's mucosa-associated lymphoid tissues. Variability of HAdV sequences suggests that cross-infections between patients were very rare. ABBREVIATIONS: GvHD: graft-versus-host disease; HAdV: human adenoviruses; HSCT: hematopoietic stem cell transplantation. PMID: 29591536 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 31, 2018 Category: Hematology Tags: Hematology Source Type: research

Modifying factors of the health belief model associated with missed clinic appointments among individuals with sickle cell disease.
CONCLUSIONS: Our findings demonstrate that modifying components of the Health Belief Model, including age, financial security, health literacy, spirituality, and lacking cues to action like reminders, are important in missed appointments and addressing these factors could improve appointment-keeping for adults and children with SCD. PMID: 29595096 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 31, 2018 Category: Hematology Tags: Hematology Source Type: research

Health-related quality of life before and after hematopoietic stem cell transplant: evidence from a survey in Suzhou, China.
Authors: Liang Y, Wang H, Niu M, Zhu X, Cai J, Wang X Abstract OBJECTIVES: The aim of our longitudinal study was to explore changes in HRQOL over a 6-month period and to identify factors associated with the HRQOL of HSCT recipients. METHOD: Our study comprised 191 HSCT patients; their data were collected before transplantation and at 30, 90, and 180 days posttransplantation. The Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) questionnaire was used to assess HRQOL.We also evaluated the patients' demographic characteristics and clinical histories to determine the relative contributions ...
Source: Hematology - March 30, 2018 Category: Hematology Tags: Hematology Source Type: research

ISH Newsletter.
Authors: PMID: 29576003 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children.
Authors: Sezer RG, Akoğlu HA, Bozaykut A, Özdemir GN Abstract OBJECTIVE: Although, oral replacement for vitamin B12 deficiency has been proved to be effective in adults, it is mainly treated with parenteral therapy. There are only few studies on oral replacement therapy of vitamin B12 with children. Therefore, we aimed to compare the efficacy of oral treatment with intramuscular vitamin B12 injections in pediatric population. METHODS: Children with serum cobalamin concentrations less than 300 pg/mL, were treated either with the parenteral therapy or with oral vitamin B12. The primary and secondary outco...
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Statement of Retraction.
Authors: PMID: 29578377 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Comparative assessment of prophylactic transfusions of platelet concentrates obtained by the PRP or buffy-coat methods, in patients undergoing allogeneic hematopoietic stem cell transplantation.
Authors: Fernández-Muñoz H, Plaza EM, Rivera-Caravaca JM, Candela MJ, Romera M, De Arriba F, Lozano ML, Vicente V, Heras I, Castilla-Llorente C, Rivera J Abstract OBJECTIVES: Whole blood-derived platelet concentrates can be obtained by the platelet-rich plasma (PRP-PCs) or the buffy-coat (BC-PCs) method. Few studies have shown that BC-PCs display lower in vitro platelet activation, but scarce information exists regarding transfusion efficacy. We have performed a retrospective study assessing platelet transfusion in patients undergoing allogeneic hematopoietic cell transplantation (AHCT) in our clinic,...
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Synergistic effects of rmhTRAIL and 17-AAG on the proliferation and apoptosis of multiple myeloma cells.
CONCLUSION: The combined application of rmhTRAIL and 17-AAG revealed favorable synergistic effects in the treatment of MM. PMID: 29566599 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 24, 2018 Category: Hematology Tags: Hematology Source Type: research

Evaluation of hypercoagulability with rotational thromboelastometry in children with iron deficiency anemia.
This study conforms to ethical standards, has been approved by the appropriate Institutional Review Board. RESULTS: Hemoglobin, serum iron, transferrin saturation and ferritin levels were lower in the IDA group than in the control group (p  0.05). The EXTEM and INTEM MCF in the IDA group was higher than in the control group, while the INTEM CFT and rate of ML60% were lower than in the control group (p 
Source: Hematology - March 20, 2018 Category: Hematology Tags: Hematology Source Type: research

Calreticulin mutation analysis in non-mutated Janus kinase 2 essential thrombocythemia patients in Chiang Mai University: analysis of three methods and clinical correlations.
CONCLUSIONS: The prevalence of CALR mutation in JAK2V617F-negative ET in this study is 35.7%. HRM is an effective method of detecting CALR mutation and is a more advantageous method of screening for CALR mutation. PMID: 29521158 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 11, 2018 Category: Hematology Tags: Hematology Source Type: research

Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates.
CONCLUSIONS: This study showed that the values of haematological parameters, especially haematocrit, Hb, MCV, MCH, MCHC and red blood cell distribution width (RDW), are lower in patients with IDA, especially when associated with α-thal and therefore it may be useful to discriminate between the different types of microcytic anaemia. PMID: 29521164 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 11, 2018 Category: Hematology Tags: Hematology Source Type: research

Impact on acute myeloid leukemia relapse in granulocyte colony-stimulating factor application: a meta-analysis.
DISCUSSION: Treatment with chemotherapy plus G-CSF appears to provide better survival and treatment responses compared with chemotherapy alone, particularly for patients with previously untreated AML. ABBREVIATIONS: AML, acute myeloid leukemia; CI, confidence interval; CR, complete remission; DFS, disease-free survival; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor; HR, hazard ratio; MDS, myelodysplastic syndrome; OR, odds ratio; OS, overall survival; RCTs, randomized control trials; RR, relative risk. PMID: 29516766 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 10, 2018 Category: Hematology Tags: Hematology Source Type: research

The prognostic impact of long noncoding RNA HOTAIR in leukemia and lymphoma: a meta-analysis.
CONCLUSION: HOTAIR played an important prognostic role in leukemia and lymphoma and might serve as a potential target for therapeutic intervention in those patients. PMID: 29513085 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 8, 2018 Category: Hematology Tags: Hematology Source Type: research

Cell proliferation and inhibition of apoptosis are related to c-Kit activation in leukaemic lymphoblasts.
CONCLUSION: These results suggest that, in leukaemic lymphoblasts, c-Kit triggers a signalling pathway with proliferative and anti-apoptotic effects; information to this effect has not yet been reported in the literature. PMID: 29495952 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 4, 2018 Category: Hematology Tags: Hematology Source Type: research

Multidrug resistance 1 (MDR1/ABCB1) gene polymorphism (rs1045642 C   >  T) and susceptibility to multiple myeloma: a systematic review and meta-analysis.
CONCLUSION: This meta-analysis suggests that the MDR1 C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed. PMID: 29495954 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 4, 2018 Category: Hematology Tags: Hematology Source Type: research

Preliminary investigation about the expression of tubulin in platelets from patients with iron deficiency anemia and thrombocytosis.
CONCLUSION: Some patients with IDA are accompanied by thrombocytosis, from which the expression of α-tubulin and β-tubulin within platelets reduced obviously compared with those with normal platelet counts and healthy controls respectively. It is implied that downregulation of tubulin probably is a part of the pathogenesis leading to increased platelet counts in IDA. PMID: 29499633 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 4, 2018 Category: Hematology Tags: Hematology Source Type: research

Novel mutation (R192C) in CYB5R3 gene causing NADH-cytochrome b5 reductase deficiency in eight Indian patients associated with autosomal recessive congenital methemoglobinemia type-I.
DISCUSSION: Eight index cases from four unrelated families were referred for the cause of cyanosis. All patients showed mild to moderate cyanosis without mental retardation or any neurologic abnormalities. The methemoglobin levels were in the range of 11.5-22.41% with 50-70% reduction in CYTB5R activity. Spectroscopic analysis of the hemolysate showed normal peaks suggesting the absence of Hb-M. Molecular characterization showed a novel homozygous mutation p.Arg192Cys in CYB5R3 gene is an evolutionarily conserved position located in exon 7 in all eight index cases. The substitution of Cys is located on the interface of two...
Source: Hematology - March 1, 2018 Category: Hematology Tags: Hematology Source Type: research

Association of human platelet antigen polymorphisms with platelet count and mean platelet volume.
CONCLUSIONS: This study demonstrates that HPA-2, -5 and -15 polymorphisms are associated with the platelet count while HPA-5 polymorphism is associated with MPV. This finding will further our understanding of the association of HPA polymorphisms with platelet-related diseases. PMID: 29486655 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 1, 2018 Category: Hematology Tags: Hematology Source Type: research

Clinical outcomes of myeloid/lymphoid neoplasms with fibroblast growth factor receptor-1 (FGFR1) rearrangement.
CONCLUSION: The further accumulation of clinical data is needed to determine the optimal therapeutic approach for these neoplasms. PMID: 29486661 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 1, 2018 Category: Hematology Tags: Hematology Source Type: research

Outcomes with frontline nilotinib treatment in Turkish patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase.
CONCLUSION: These results support the use of nilotinib 300 mg twice daily as a standard-of-care treatment option for patients with newly diagnosed CML-CP with low and intermediate risk. PMID: 29486663 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 1, 2018 Category: Hematology Tags: Hematology Source Type: research

Renal involvement in paroxysmal nocturnal hemoglobinuria: an update on clinical features, pathophysiology and treatment.
CONCLUSION: Understanding the difficult but at the same time impressive mechanisms behind PNH remains a challenge for treating physicians. PMID: 29486674 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 1, 2018 Category: Hematology Tags: Hematology Source Type: research

Erratum.
Authors: PMID: 29471729 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 25, 2018 Category: Hematology Tags: Hematology Source Type: research

Mometasone furoate inhibits growth of acute leukemia cells in childhood by regulating PI3K signaling pathway.
CONCLUSION: This study reveals that MF can inhibit proliferation and invasion/migration and induce apoptosis in Childhood ALL cells, which may be regulated by Phosphatidylinositol 3-kinase signaling pathway. These results suggest MF may be a potential new drug target for clinical ALL treatment. PMID: 29421985 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 11, 2018 Category: Hematology Tags: Hematology Source Type: research

Immune dysregulation in primary immune thrombocytopenia patients.
CONCLUSION: ITP patients presented with a high CD4/CD8 ratio and low levels of Tregs and NK cells, suggesting that immune deregulation was involved in the pathogenesis of ITP. The pre-treated immune status of ITP patients may not be related to the curative effect. Tregs significantly increased in the effective group post-treatment, highlighting that the mechanism of restoring Tregs may be involved in the treatment of ITP. However, whether or not the targeted regulation of Tregs is an effective treatment for ITP still requires further studies. PMID: 29409398 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Danazol increases T regulatory cells in patients with aplastic anemia.
Authors: Khurana H, Malhotra P, Sachdeva MU, Varma N, Bose P, Yanamandra U, Varma S, Khadwal A, Lad D, Prakash G Abstract OBJECTIVES: Danazol is an attenuated androgen and is used in the treatment of aplastic anemia (AA) in resource constraint settings. We chose to study the role of CD4+ CD25high CD127low FoxP3+ T regulatory cells (T-regs) in the pathophysiology of AA and their response to treatment with Danazol alone or in combination with immunosuppressive treatment (IST). METHODS: T-regs' percentages of 25 acquired idiopathic AA patients and 25 healthy controls who completed study protocol were analyzed by p...
Source: Hematology - February 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Low expression of Mda-7/IL-24 and high expression of C-myb in tumour tissues are predictors of poor prognosis for Burkitt lymphoma patients.
CONCLUSION: These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma. ABBREVIATIONS: Mda-7/IL-24: melanoma differentiation associated gene7/interleukin 24; FCM: flow cytometry; Ecog: Eastern Cooperative Oncology Group; IPI: International lymphoma prognosis index. PMID: 29415639 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Eliezer Rachmilewitz (1935-2017).
Authors: PMID: 29400141 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - February 6, 2018 Category: Hematology Tags: Hematology Source Type: research

Dyspareunia is associated with chronic pain in premenopausal women with sickle cell disease.
CONCLUSION: Dyspareunia is common in women with SCD, and more common in women with SCD and chronic pain. Providers should assess women with SCD for dyspareunia, especially those with a chronic pain syndrome. PMID: 29376481 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 30, 2018 Category: Hematology Tags: Hematology Source Type: research

Corrigendum.
Authors: PMID: 29351728 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 22, 2018 Category: Hematology Tags: Hematology Source Type: research

Expression and role of granulocyte macrophage colony-stimulating factor receptor (GM-CSFR) and granulocyte colony-stimulating factor receptor (G-CSFR) on Ph-positive acute B lymphoblastic leukemia.
CONCLUSION: We demonstrated high expression levels of GM-CSFR and G-CSFR, as well as their promotable role for viability in ph + ALL cells. We further found that rhG-CSF influenced the sensitivity of SUP-B15 cells to TKIs. PMID: 29338593 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Utility of mean sphered cell volume and mean reticulocyte volume for the diagnosis of hereditary spherocytosis.
Authors: Arora RD, Dass J, Maydeo S, Arya V, Kotwal J, Bhargava M Abstract INTRODUCTION: Hereditary spherocytosis (HS) is the most common congenital hemolytic anemia, characterized by anemia, jaundice, and splenomegaly. The diagnosis of HS relies on symptoms of hemolysis, a family history of HS, and a positive laboratory test which is usually the osmotic fragility test (OFT). We conducted a study to assess the utility of mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), mean sphered cell volume (MSCV), and mean reticulocyte volume (MRV) in the diagnosis of HS and if these are helpful ...
Source: Hematology - January 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Adjuvant radiotherapy in patients with diffuse large B-cell lymphoma in advanced stage (III/IV) improves the outcome in the rituximab era.
Authors: Avilès A, Nambo MJ, Calva A, Neri N, Cleto S, Silva L Abstract OBJECTIVES: To assess the efficacy and toxicity of adjuvant radiotherapy (RT) in patients with diffuse large B-cell lymphoma (DLBCL) and nodal bulky disease, on complete response, after six cycles of RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone), we began an open-label clinical trial in a large cohort with longer follow-up to evaluate the outcome measured from progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS: Between 2006 and 2010, 258 consecutive patients with DLBCL and n...
Source: Hematology - January 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Prevalence of iron deficiency in a total joint surgery population.
Authors: Waters JH, Johnson P, Yazer MH Abstract BACKGROUND: Iron deficiency without anemia has been associated with decreases in functional work capacity and fatigue. The aim of this study was to determine the prevalence of iron deficiency without anemia in a preoperative cohort of orthopedic patients and to determine if iron deficiency is a condition which warrants inclusion into a prehabilitation program prior to surgery. METHODS: One hundred consecutive patients going through preoperative testing for total joint replacement were enrolled in the study. In addition to the standard preoperative complete blood ...
Source: Hematology - January 12, 2018 Category: Hematology Tags: Hematology Source Type: research

Relationship between obesity and iron deficiency anemia: is there a role of hepcidin?
Authors: Sal E, Yenicesu I, Celik N, Pasaoglu H, Celik B, Pasaoglu OT, Kaya Z, Kocak U, Camurdan O, Bideci A, Cinaz P Abstract OBJECTIVES: Iron deficiency is common in obese children although the underlying mechanism is unclear. The aim of this study was to investigate the associations between iron parameters, leptin, hepcidin and adiponectin levels in obese children. METHODS: A total of 237 children, ranging in age from 5 to 18 years, 180 with primary obesity and 57 healthy children and adolescents, were enrolled. Complete blood count, serum iron levels, iron-binding capacity, ferritin levels, leptin, hepcidin...
Source: Hematology - January 12, 2018 Category: Hematology Tags: Hematology Source Type: research

Pathogenicity analysis of variations and prenatal diagnosis in a hereditary coagulation factor XIII deficiency family.
DISCUSSION: We first established the PND procedure with pathogenicity assessment in FXIIID patients. The F13A gene mutations' spectrum of the Chinese Han population was enriched. PMID: 29307277 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

Incidence of Fanconi anaemia in phenotypically normal aplastic anaemia patients in West Bengal.
CONCLUSION: This observation may indicate that stress cytogenetics analysis of phenotypically normal AA patients (≤50 years) is essential for the improvement of the treatment procedure. PMID: 29307285 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

The potential association of CMV-specific CD8+ T lymphocyte reconstitution with the risk of CMV reactivation and persistency in post allogeneic stem cell transplant patients.
CONCLUSION: CMV-specific CD8+ cells can help in categorizing patients into risk groups: (early recovery/low risk) and (delayed recovery/increased risk), this tool may guide clinicians in the selection of patients who may profit from prophylactic antiviral therapy and frequent viral monitoring. PMID: 29313439 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

Thrombopoietin and its receptor expression in pediatric patients with chronic immune thrombocytopenia.
This study aimed to determine whether thrombopoietin (TPO) and its receptor c-mannosylation of the TPO receptor (c-Mpl) have an impact on childhood cITP. METHODS: Sixty-four patients with newly diagnosed ITP (nITP), 64 patients with persistent ITP, 80 patients with cITP, and 64 healthy children (control) were enrolled in this study. Plasma TPO was measured with an ELISA, and c-Mpl was determined by flow cytometry. RESULTS: Plasma TPO levels showed differences among the four groups (p = 0.001). TPO levels in the cITP group were significantly decreased compared to those in the nITP group (p 
Source: Hematology - January 10, 2018 Category: Hematology Tags: Hematology Source Type: research

Eltrombopag in the management of aplastic anaemia: real-world experience in a non-trial setting.
CONCLUSION: In a routine haematological practice, the use of eltrombopag in AA patients was feasible, safe, and associated with very favourable responses. PMID: 29303047 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 7, 2018 Category: Hematology Tags: Hematology Source Type: research

Is there a difference in phenotype between males and females with non-transfusion-dependent thalassemia? A cross-sectional evaluation.
CONCLUSION: This data should be considered in studies with experimental treatments aiming to correct anemia in patients with non-transfusion-dependent thalassemia. It should probably also be taken into account in order to set up different transfusion regimens among genders in transfusion-dependent patients. PMID: 29303050 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - January 7, 2018 Category: Hematology Tags: Hematology Source Type: research