Efficacy and safety of iron chelator for transfusion-dependent patients with myelodysplastic syndrome: a meta-analysis.
Authors: Zhang J, Shi P, Liu J, Li J, Cao Y Abstract To systematically evaluate the efficacy and safety of iron chelators for transfusion-dependent patients with MDS. Thirteen cohort studies with 12,990 patients diagnosed with MDS were included in this study. According to m eta-analysis results transfusion-dependent MDS patients with secondary iron overload had a longer (HR = 0.52, 95%CI = 0.43-0.62, P 
Source: Hematology - September 25, 2019 Category: Hematology Tags: Hematology Source Type: research

Clinical characteristics and prognostic factors in Chinese patients with classical Hodgkin's lymphoma involving extranodal sites: a retrospective single-center.
Conclusion: Extranodal involvement was frequent in Chinese cHL patients, with lung to be the most commonly involved site. Lymphocytopenia was the only independent adverse prognostic factor. PMID: 31537183 [PubMed - in process] (Source: Hematology)
Source: Hematology - September 22, 2019 Category: Hematology Tags: Hematology Source Type: research

Targeting on glycosylation of mutant FLT3 in acute myeloid leukemia.
Conclusions: The abnormal location of FLT3 caused by different glycosylation status leads to the distinguishing signaling pathways. Targeting on FLT3 glycosylation may provide a new perspective for therapeutic strategies. Abbreviations: ABCG2: ATP-binding cassette transporter breast cancer resistance protein; ATF: activating transcription factor; AML: acute myeloid leukemia; CHOP: CCAAT-enhancer-binding protein homologous protein; 2-DG: 2-deoxy-D-glucose; EFS: event free survival; EPO: erythropoietin; EPOR: erythropoietin receptor; ERS: endoplasmic reticulum stress; FLT3: FMS-like tyrosine kinase 3; GPI: glycosylphosphatid...
Source: Hematology - September 21, 2019 Category: Hematology Tags: Hematology Source Type: research

Proteomic tools and new insights for the study of B-cell precursor acute lymphoblastic leukemia.
Authors: Citalan-Madrid AF, Cabral-Pacheco GA, Martinez-de-Villarreal LE, Villarreal-Martinez L, Ibarra-Ramirez M, Garza-Veloz I, Cardenas-Vargas E, Marino-Martinez I, Martinez-Fierro ML Abstract B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a hematological malignancy of immature B-cell precursors, affecting children more often than adults. The etiology of BCP-ALL is still unknown, but environmental factors, sex, race or ethnicity, and genomic alterations influence the development of the disease. Tools based on protein detection, such as flow cytometry, mass spectrometry, mass cytometry and reverse pha...
Source: Hematology - September 15, 2019 Category: Hematology Tags: Hematology Source Type: research

Inhibitor eradication and bleeding management of acquired hemophilia A: a single center experience in China.
This study reports the clinical characteristics and treatment outcomes of a relatively sizable cohort of patients with AHA. Methods: We retrospectively analyzed the characteristics and outcomes of 42 patients with AHA diagnosed in our center from January 2014 through December 2018. Results: The FVIII activity (FVIII: C) was significantly suppressed (median 1.5%; interquartile range [IQR]: 0.9-3.5) by FVIII inhibitor (median 8 BU/mL; IQR: 4.0-16.0). Bypassing agents, PCC or FVIIa, were used in 14 patients for bleeding control without any adverse reaction; and most patients (90.5%, 38/42) were placed on immunosuppressive reg...
Source: Hematology - September 15, 2019 Category: Hematology Tags: Hematology Source Type: research

Yttrium-90 ibritumomab tiuxetan consolidation versus rituximab maintenance therapy after induction chemotherapy in patients with indolent non-Hodgkin lymphoma: a single-institution experience.
CONCLUSION: 90Y-IT consolidation and rituximab maintenance were similar with respect to PFS, OS, and TTNT. However, the features and grades of adverse effects significantly differed. Patient-specific characteristics should be considered when deciding post-remission treatments. PMID: 31496425 [PubMed - in process] (Source: Hematology)
Source: Hematology - September 11, 2019 Category: Hematology Tags: Hematology Source Type: research

Prognostic value of DNMT3A mutations in myelodysplastic syndromes: a meta-analysis.
In this study, we conducted a meta-analysis to determine the prognostic effect of DNMT3A mutations in patients with MDS. Methods: Eligible studies from PubMed, Embase, Web of Science, Clinical Trials and the Cochrane Library were searched. Hazard ratios (HRs) and their 95% confidence intervals (CIs) for overall survival (OS) and leukemia-free survival (LFS) were pooled to assess the effect of DNMT3A mutations on the prognosis in MDS patients. Results: A total of 12 studies with 2236 patients were included in this meta-analysis. The pooled HRs for OS and LFS revealed that MDS patients with DNMT3A mutations had a significant...
Source: Hematology - September 5, 2019 Category: Hematology Tags: Hematology Source Type: research

Risk factors of early death in adult patients with secondary hemophagocytic lymphohistiocytosis: a single-institution study of 171 Chinese patients.
Authors: Zhao Y, Lu D, Ma S, Li L, Zhu J, Zhou, Zheng Y, Yang X, Zhu L, Zhu M, Xie M, Sun J, Ye X, Xie W Abstract Background: Adult secondary hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome characterized by excessive activation of mononuclear-phagocytic system resulting in hyperinflammatory response. To date, the factors influencing early death of HLH are still not fully elucidated. Patients and Methods: We did a retrospective study of 171 adult patients with newly diagnosed HLH at our institution from January 2012 to April 2018. All patients' clinical features, laboratory findin...
Source: Hematology - September 4, 2019 Category: Hematology Tags: Hematology Source Type: research

Expression and CpG island methylation pattern of MMP-2 and MMP-9 genes in patients with congenital factor XIII deficiency and intracranial hemorrhage.
CONCLUSION: Our findings indicated that MMP-9 over-expression might be related to ICH in FXIII deficiency, and gene methylation effectively regulates its expression. Future researches will expand our understanding of the pathogenesis of ICH in congenital FXIII deficiency. PMID: 31469059 [PubMed - in process] (Source: Hematology)
Source: Hematology - September 1, 2019 Category: Hematology Tags: Hematology Source Type: research

The challenges of handling deferasirox in sickle cell disease patients older than 40 years.
Discussion and conclusions: Deferasirox does not appear to be well tolerated in SCD patients older than 40 years, in which complications of the underlying disease are already fully installed. The choice of the ideal iron chelator for this population should include an evaluation of comorbidities and organic dysfunctions, as well as the need to find pharmacogenetic safety markers in this group of patients. PMID: 31434554 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 23, 2019 Category: Hematology Tags: Hematology Source Type: research

Diagnosis and treatment of juvenile myelomonocytic leukemia.
Conclusion: The PLT count, LDH level, HbF level and choice of treatment plan are important for the evaluation of prognosis for children with JMML. Although there is a lack of consistency in terms of donors but the A-3V scheme is relatively stable, so HSCT should be preferred for children with poor prognostic factors. PMID: 31389303 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 9, 2019 Category: Hematology Tags: Hematology Source Type: research

Targeted next-generation sequencing identified a novel ANK1 mutation associated with hereditary spherocytosis in a Chinese family.
Conclusion: The present study confirmed that a novel mutation in ANK1 may be causative of HS, which plays an important role in expanding the mutational spectrum of ANK1 mutations. This may contribute to accurate genetic counselling. And it is helpful for understanding the correlation of the genotype and phenotype. PMID: 31390973 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 9, 2019 Category: Hematology Tags: Hematology Source Type: research

Expression of BTK/p-BTK is different between CD5+ and CD5- B lymphocytes from Autoimmune Hemolytic Anemia/Evans syndromes.
Conclusions: CD5+B lymphocytes are the major B subtype that is activated in AIHA/ES patients and it positively correlates with IgE. PMID: 31392938 [PubMed - in process] (Source: Hematology)
Source: Hematology - August 9, 2019 Category: Hematology Tags: Hematology Source Type: research

The clinical values of dysregulated DNA methylation and demethylation intermediates in acute lymphoblastic leukemia.
Conclusion: This study described a novel role for global methylation and demethylation intermediates in ALL detection and prognosis, and provided new clue to distinguish high-risk patients and improve the curative effect on ALL patients. PMID: 31315520 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma.
Conclusion: Our findings suggest that overexpression of IgD and IgDR is an abnormal activation state in DLBCL. PMID: 31315540 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Analysis of gene mutation characteristics in patients with chronic neutrophilic leukaemia.
Conclusion and Discussion: CSF3R mutation is the main tumorigenic mutation in CNL, in which CSF3R T618I mutation is the main mutation, and an extremely small number of CNL patients may be caused by JAK2 V617F mutation. SETBP1 and ASXL1 are the most common concomitant mutations in CNL with CSF3R mutation, and SETBP1 and CSF3R T618Imutations may have a certain correlation. PMID: 31315541 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Pathogenesis of aplastic anemia.
Authors: Wang L, Liu H Abstract Aplastic anemia (AA) is a rare and life-threatening bone marrow failure (BMF) that results in peripheral blood cytopenia and reduced bone marrow hematopoietic cell proliferation. The symptoms are similar to myelofibrosis, myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) making diagnosis of AA complicated. The pathogenesis of AA is complex and its mechanism needs to be deciphered on an individualized basis. This review summarizes several contributions made in trying to understand AA pathogenesis in recent years which may be helpful for the development of personalized t...
Source: Hematology - July 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Minimal residual disease may be an early prognostic indicator for newly diagnosed acute myeloid leukemia patients induced by decitabine-based chemotherapy.
Conclusions: Decitabine-based chemotherapy may be a suitable therapeutic alternative for newly diagnosed AML patients who are unfit for intensive chemotherapy. An advanced age (≥ 60 years) and higher MRD (≥ 1.34%) were considered adverse prognostic factors. PMID: 31315553 [PubMed - in process] (Source: Hematology)
Source: Hematology - July 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Ficolled bone marrow is superior to bone marrow buffy coat for detection of minimal residual disease in multiple myeloma.
Authors: Bai Y, Chim CS Abstract OBJECTIVE: Buffy coat and ficoll of bone marrow (BM) are viable options for the study of minimal residual disease (MRD) in multiple myeloma (MM). As yet, there is no data about the superiority of either sample types. Herein, we aimed to address this issue. METHODS: Forty pairs of ficolled BMs and BM buffy coats of 19 MM patients were studied for MRD by allele-specific oligonucleotide real-time quantitative PCR, with patient-specific primers/probes whenever appropriate. RESULTS: There were 41 pairs of MRD data for comparison analysis due to one patient with biclonal disease...
Source: Hematology - July 12, 2019 Category: Hematology Tags: Hematology Source Type: research

Association of diabetes mellitus with non-Hodgkin lymphoma risk: a meta-analysis of cohort studies.
Authors: Xu J, Wang T Abstract Background: Diabetes mellitus (DM) is considered to be a risk factor in the prognosis of many types of cancer, but the effect of DM on the risk of non-Hodgkin lymphoma (NHL) is still under dispute. We performed this study to examine the association between DM and subsequent NHL risk. Methods: A systematically search had been performed in PubMed, EmBase, and the Cochrane Library to identify eligible studies from inception to September 2018. Results: Thirteen cohort studies were included, with a total of 9024761 participants. The results showed that DM was associated with an increased r...
Source: Hematology - July 3, 2019 Category: Hematology Tags: Hematology Source Type: research

RETRACTED ARTICLE: Retraction.
Authors: PMID: 31251119 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 30, 2019 Category: Hematology Tags: Hematology Source Type: research

Improvement of the hematologic toxicities of ruxolitinib in patients with MPN-associated myelofibrosis using a combination of thalidomide, stanozolol and prednisone.
Authors: Duan M, Zhou D Abstract Objective: Anemia and thrombocytopenia are the most frequently reported adverse events of ruxolitinib in patients with MPN-associated myelofibrosis (MPN-MF). Although thalidomide, androgens and prednisone have previously demonstrated improvements in myelofibrosis-associated anemia, it is unclear whether these drugs are effective in patients taking ruxolitinib. Method: We conducted a retrospective cohort study to evaluate the efficacy and tolerability of combination therapy with low dose thalidomide, stanozolol and prednisone (TSP) in patients with IPSS intermediate-2 or high-risk my...
Source: Hematology - June 29, 2019 Category: Hematology Tags: Hematology Source Type: research

Use of decitabine for patients with refractory or relapsed acute myeloid leukemia: a systematic review and meta-analysis.
Conclusion: Decitabine in combination with chemotherapy or molecular therapy has shown efficacious properties in refractory or relapsed AML patients. PMID: 31242832 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 29, 2019 Category: Hematology Tags: Hematology Source Type: research

Clinical outcomes of immunosuppressive therapy for severe aplastic anemia patients with absolute neutrophil count of zero.
Conclusion: Adult SAA patients with ANC = 0 had a very poor prognosis and new therapeutic regimens may result in better outcome for these patients. PMID: 31221029 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 23, 2019 Category: Hematology Tags: Hematology Source Type: research

A systematic review and meta-analysis of the efficacy and adverse events of azacitidine-plus-lenalidomide treatment for patients with acute myeloid leukemia, myelodysplastic syndromes and chronic myelomonocytic leukemia 1.
CONCLUSIONS: The current study may serve as a preliminary data to suggest that the addition of LEN may offer incremental benefit to patients with high-risk MDS, AML and CMML. However, randomized-controlled studies that directly compare the efficacy and adverse events of AZA-plus-LEN regimen versus AZA monotherapy are still needed. PMID: 31221030 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 23, 2019 Category: Hematology Tags: Hematology Source Type: research

Transcriptome analysis identifies key regulators and networks in Acute myeloid leukemia.
CONCLUSION: Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML. PMID: 31210592 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Wilms' tumor 1 mRNA expression: a good tool for differentiating between myelodysplastic syndrome and aplastic anemia in children?
Conclusion: WT1 expression might be useful for distinguishing between myelodysplastic syndrome and aplastic anemia in children. PMID: 31210595 [PubMed - in process] (Source: Hematology)
Source: Hematology - June 20, 2019 Category: Hematology Tags: Hematology Source Type: research

The imbalance between regulatory memory B cells reveals possible pathogenesis involvement in pediatric immune thrombocytopenia.
In this study, the balance of these subsets was investigated in pediatric immune thrombocytopenia (ITP) patients, and the frequencies of Bregs and Bmems before and after first-line therapy were measured. Methods: Forty-nine pediatric ITP patients and 19 normal controls were enrolled in this study. The total CD19+ B cells, Bregs and Bmems in the peripheral blood (PB) of all cases were measured by flow cytometry. Results: We found higher frequencies of total CD19+ B cells and Bmems in newly diagnosed ITP patients than those in normal controls (p 
Source: Hematology - June 2, 2019 Category: Hematology Tags: Hematology Source Type: research

Interactions of unstable hemoglobin Rush with thalassemia and hemoglobin E result in thalassemia intermedia.
Conclusions: Unstable Hb Rush interacting with β-thalassemia result in thalassemia intermedia phenotypes, which demonstrated the clinical significance of Hb Rush and new insights into complex mechanism of clinical heterogeneity of thalassemia. PMID: 31124399 [PubMed - in process] (Source: Hematology)
Source: Hematology - May 28, 2019 Category: Hematology Tags: Hematology Source Type: research

Time course of peripheral blood count recovery during induction chemotherapy for childhood acute lymphoblastic leukemia.
Authors: Grunnan JD, Rosthøj S Abstract Introduction: Children with newly diagnosed acute lymphoblastic leukemia (ALL) present with low peripheral blood counts caused by bone marrow replacement. The recovery of counts during induction chemotherapy is not well described. Material and methods: Records for 63 children with ALL were reviewed. Peripheral hematology blood counts during five weeks of induction chemotherapy were extracted, and the time to partial recovery with safe counts and complete recovery with normal counts in the three cell lines determined. The number of red cell and platelet transfusions, th...
Source: Hematology - May 28, 2019 Category: Hematology Tags: Hematology Source Type: research

Upfront autologous hematopoietic stem cell transplantation in patients with high-risk stage III to IV Hodgkin lymphoma: a multicenter retrospective cohort study.
CONCLUSION: The use of ASCT as a first-line consolidation treatment could improve outcome of patients with advanced-stage high risk HL whose interim PET/CT was positive. PMID: 31081725 [PubMed - in process] (Source: Hematology)
Source: Hematology - May 14, 2019 Category: Hematology Tags: Hematology Source Type: research

Clonal evolution in a chronic neutrophilic leukemia patient.
We present a male patient who presented peripheral blood leukocytosis. On the basis of his morphological appearances and molecular findings he was determined to have a diagnosis of chronic neutrophilic leukemia. At a follow-up at 7 months, in addition to the CSF3R c.2373G > A (p.W791*) truncated mutation, another CSF3R mutation appeared as c.1853C > T(p.T618I). Discussion and conclusion: We present the first patient with a diagnosis of chronic neutrophilic leukemia with a c.2373G > A (p.W791*) truncated mutation of CSF3R. These findings elucidate a novel paradigm of CNL pa...
Source: Hematology - May 13, 2019 Category: Hematology Tags: Hematology Source Type: research

Advances in the treatment and prognosis of anaplastic lymphoma kinase negative anaplastic large cell lymphoma.
Authors: Wang X, Wu J, Zhang M Abstract Anaplastic lymphoma kinase negative anaplastic large cell lymphoma (ALK- ALCL) is a definite entity in the WHO 2016 Classification that represents 2-3% of non-Hodgkin lymphoma (NHL) and 12% of T-cell NHL cases. ALK- ALCL lacks ALK protein expression, but expresses CD30 and has morphologic features similar to ALK positive anaplastic large cell lymphoma (ALK+ ALCL). Some studies indicate that ALK- ALCL and ALK+ ALCL possess different molecular and genetic characteristics. Besides, ALK- ALCL is worse than ALK+ ALCL in terms of treatment outcome, prognosis, and long-term survival...
Source: Hematology - May 11, 2019 Category: Hematology Tags: Hematology Source Type: research

Clinicopathologic significance and therapeutic implication of de novo CD5+ diffuse large B-cell lymphoma.
CONCLUSION: CD5+ DLBCL patients have the distinctive clinical and biological features, they should be provided with clinic individualized treatment and important pathways with therapeutic implications should be underscored. PMID: 31072235 [PubMed - in process] (Source: Hematology)
Source: Hematology - May 11, 2019 Category: Hematology Tags: Hematology Source Type: research

ISH Newsletter.
Authors: PMID: 30994051 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 18, 2019 Category: Hematology Tags: Hematology Source Type: research

Beta-thalassemia: renal complications and mechanisms: a narrative review.
CONCLUSION: Kidney disease may develop through progressive renal tubular and glomerular damage; thus, its early recognition is important in order to prevent and/or reverse deterioration. This review will provide an insight on the involved mechanisms implicated in kidney disease in thalassemic patients and will discuss the updates on diagnosis and prevention of renal complications in thalassemia. PMID: 30947625 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 7, 2019 Category: Hematology Tags: Hematology Source Type: research

Compound heterozygous mutations Glu502Lys and Met527Thr of the FXII gene in a patient with factor XII deficiency.
CONCLUSION: We detected two missense mutations Glu502Lys and Met527Thr in the catalytic domain of the proband, of which Met527Thr was first reported in the world. Our findings suggest that the double mutations in the FXII gene were the causing reasons for the decreased FXII:C and FXII:Ag. These results not only enriched the F12 mutation database in this condition, but also helped to identify the genetic defects of FXII in China. PMID: 30929639 [PubMed - in process] (Source: Hematology)
Source: Hematology - April 3, 2019 Category: Hematology Tags: Hematology Source Type: research

Clinical characteristics and prognostic factors of primary extranodal classical Hodgkin lymphoma: a retrospective study.
Authors: Yang M, Ping L, Liu W, Xie Y, Aliya, Liu Y, Nuersulitan R, Zhu J, Wu M, Song Y Abstract OBJECTIVES: To analyze the clinical characteristics and prognosis of primary extranodal classical Hodgkin lymphoma (PE-cHL). METHODS: Clinical features and outcomes of 22 PE-cHL patients who received initial chemotherapy January 2008 to January 2018 were analyzed retrospectively, and compared with 274 primary nodal Hodgkin lymphoma (PN-cHL) patients treated in the same period. RESULTS: With a median follow-up period of 42 months, compared with 274 PN-cHL patients, no significant difference of overall response ra...
Source: Hematology - March 31, 2019 Category: Hematology Tags: Hematology Source Type: research

Abnormalities of quantities and functions of CD56bright natural killer cells in non-severe aplastic Anemia.
In this study, we analyzed the quantitative and functional changes of CD56bright NK cells in peripheral blood of patients with NSAA by using Flow Cytometry (FCM) before and after immunosuppressive therapy (IST). The expressions of activating receptor (NKG2D, NKp46, NKp44), inhibitory receptor (NKG2A, CD158a, CD158b) and perforin and granzyme B were detected by FCM. IL-2 and IL-18 levels in serum were detected by ELISA. The correlation between these parameters and clinical indicators of patients were evaluated. RESULTS: We found that the percentage of CD56bright NK cells in newly diagnosed NSAA patients was higher than ...
Source: Hematology - March 27, 2019 Category: Hematology Tags: Hematology Source Type: research

Etiology and clinico-hematological profile of pancytopenia: experience of a Mexican Tertiary Care Center and review of the literature.
CONCLUSION: The sociocultural context in which the patients develop helps narrowing the possible etiology of pancytopenia, and therefore hasten the diagnostic process. Of all the studies available, bone marrow aspiration seems the most useful. PMID: 30890036 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 22, 2019 Category: Hematology Tags: Hematology Source Type: research

Serum platelet factor 4 is a promising predictor in newly diagnosed patients with multiple myeloma treated with thalidomide and VAD regimens.
CONCLUSIONS: We speculate serum PF4 is a promising response and prognostic factor in newly diagnosed MM treated with thalidomide and VAD regimens. PMID: 30890040 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 22, 2019 Category: Hematology Tags: Hematology Source Type: research

Soluble programmed death-ligand 1 are highly expressed in peripheral T-cell lymphoma: a biomarker for prognosis.
Authors: Shen H, Ji Y, Zhou D, Zhang Y, Wang W, Sun J, Zhang W Abstract PURPOSE: To investigate the role of soluble programmed cell death ligand 1 (sPD-L1) protein in plasma of patients with Peripheral T-cell lymphoma (PTCL). METHODS: In total, 80 patients with newly diagnosed PTCL and 75 healthy controls were enrolled. Levels of sPD-L1 were measured by ELISA at diagnosis and after 3-8 courses of chemotherapy. The expression of PD-L1 in tumor tissues from nine PTCL patients was also detected. RESULTS: sPD-L1 was higher in PTCL patients at diagnosis compared to healthy subjects (P 
Source: Hematology - March 22, 2019 Category: Hematology Tags: Hematology Source Type: research

Diagnostic and therapeutic splenectomy for splenic lymphomas: analysis of the National Cancer Data Base.
Authors: Fallah J, Olszewski AJ Abstract OBJECTIVES: To examine the use of splenectomy, chemotherapy, and subsequent overall survival (OS) in contemporary patients with splenic lymphomas. METHODS: We analyzed records of 6450 patients with various splenic lymphomas recorded in the National Cancer Data Base (2004-2013). Survival was compared using Mantel-Byer test to account for guarantee-time bias, stratified by age, sex, comorbidities, and lymphoma stage. RESULTS: Splenectomy rate was overall 58%, and varied from 49% in splenic marginal zone (SMZL) to 77% in follicular lymphoma (FL). It significantly decrea...
Source: Hematology - March 21, 2019 Category: Hematology Tags: Hematology Source Type: research

Intrathecal dose intensification by CNS status at diagnosis in the treatment of children with acute lymphoblastic leukemia.
CONCLUSIONS: ITM intensification during induction was associated with elimination of CNS recurrence in patients with CNS2 disease and childhood ALL. Controlled studies are needed to confirm this observation. PMID: 30885098 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 21, 2019 Category: Hematology Tags: Hematology Source Type: research

Outcomes of unplanned tyrosine kinase inhibitor discontinuation in patients with chronic myeloid leukemia: retrospective analysis of real-world experience in a single institution.
CONCLUSION: TKI was safely discontinued in clinical practice and yielded TFR rates similar to those observed in previous clinical trials, regardless of reason. Achievement of TFR significantly impacts patients' quality of life and should be considered in clinical practice. PMID: 30880635 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Efficacy of levofloxacin as an antibacterial prophylaxis for acute leukemia patients receiving intensive chemotherapy: a systematic review and  meta-analysis.
Efficacy of levofloxacin as an antibacterial prophylaxis for acute leukemia patients receiving intensive chemotherapy: a systematic review and meta-analysis. Hematology. 2019 Dec;24(1):362-368 Authors: Owattanapanich W, Chayakulkeeree M Abstract OBJECTIVES: The incidence of febrile neutropenia (FN) in acute leukemia patients following induction or consolidation chemotherapy is high. Several clinical practice guidelines recommend the use of a fluoroquinolone prophylaxis to prevent bacterial infection in patients being prone to prolonged profound neutropenia. METHODS: This systematic review and ...
Source: Hematology - March 20, 2019 Category: Hematology Tags: Hematology Source Type: research

Correction.
Authors: PMID: 30849295 [PubMed - in process] (Source: Hematology)
Source: Hematology - March 10, 2019 Category: Hematology Tags: Hematology Source Type: research

Correction.
Authors: PMID: 30806184 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 28, 2019 Category: Hematology Tags: Hematology Source Type: research

Clinical variability and molecular characterization of Hbs/G γ (Aγδβ)0-thal and Hbs/HPFH in Indian sickle cell disease patients: AIIMS experience.
CONCLUSION: This study highlights the importance of understanding the complex patho-physiology of compound heterozygous cases of HbS/HPFH and HbS/δβ thalassemia, as these infrequent conditions lead to change in phenotype and clinical severity of the disease. Insight into more such cases will open the window to better analyze the disease pathogenesis in these rare compound heterozygous conditions, as this will be beneficial to formulate proper management protocol in these patients. PMID: 30777489 [PubMed - in process] (Source: Hematology)
Source: Hematology - February 21, 2019 Category: Hematology Tags: Hematology Source Type: research

Minimal residual disease level predicts outcome in adults with Ph-negative B-precursor acute lymphoblastic leukemia.
This study evaluated outcomes of patients with B-cell precursor ALL with MRD of ≥10-4 Methods: Study population was from ALL study groups in Europe managed in national study protocols 2000-2014. MRD was measured by polymerase chain reaction or flow cytometry. Patients were age ≥15 years at initial ALL diagnosis. Patients were excluded if exposed to blinatumomab within 18 months of baseline or prior alloHSCT. RESULTS: Of 272 patients in CR1, baseline MRD was ≥10-1, 10-2 to
Source: Hematology - February 15, 2019 Category: Hematology Tags: Hematology Source Type: research