Efficacy and tolerability of rituximab and reduced-dose cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy for elderly patient with diffuse large B-cell lymphoma.
Authors: Kayamori K, Shono K, Onoda M, Yokota A Abstract OBJECTIVES: Chemoimmunotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with rituximab (R-CHOP) is currently the first-line therapy for diffuse large B-cell lymphoma (DLBCL). However, management of elderly patients is challenging and often requires dose reductions or prolonged treatment intervals. We investigated the proper dose of R-CHOP for them. METHODS: At our institute, for DLBCL patients aged 65-79 and ≥80 years, we had reduced CHOP dose to 5/6 and 7/12, respectively, and retrospectively evaluated the reduced-dos...
Source: Hematology - August 15, 2018 Category: Hematology Tags: Hematology Source Type: research

Association of GSTT1/GSTM1 and ApoE variants with left ventricular diastolic dysfunction in thalassaemia major patients.
CONCLUSIONS: Patients having Glutathione S-transferase M1 allele and Apolipoprotein E E2 allele are predisposed to oxidative stress-induced cardiac injury. PMID: 30095041 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 12, 2018 Category: Hematology Tags: Hematology Source Type: research

A triplex probe-based TaqMan qPCR assay for Calreticulin type I and II mutation detection.
CONCLUSIONS: Triplex probe-based TaqMan qPCR is an accurate and sensitive method for screening ET or PMF patients with type I and II mutations in CALR. PMID: 30080988 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 9, 2018 Category: Hematology Tags: Hematology Source Type: research

miR-29b inhibits the progression of multiple myeloma through downregulating FOXP1.
CONCLUSIONS: miR-29b recedes the progression of MM via downregulating FOXP1, which may provide a potential biological target for MM treatment. PMID: 30068241 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - August 5, 2018 Category: Hematology Tags: Hematology Source Type: research

Common themes and challenges in hemophilia care: a multinational perspective.
DISCUSSION: Differing healthcare reimbursement systems, budgetary constraints, and geographical and cultural factors make it difficult for any country to fully deliver ideal care for people with hemophilia. The SHIELD approach for collaborative care provides illustrative examples of how four key themes can be used to optimize hemophilia care in any setting. ABBREVIATIONS: AHCDC: Association of Hemophilia Clinic Directors of Canada; AICE: Italian Association of Hemophilia Centres; ATHN: American Thrombosis and Hemostasis Network; EAHAD: European Association for Haemophilia and Allied Disorders; EHC: European Hemophilia ...
Source: Hematology - August 5, 2018 Category: Hematology Tags: Hematology Source Type: research

The influence of MTHFR genetic polymorphisms on adverse reactions after methotrexate in patients with hematological malignancies: a meta-analysis.
CONCLUSION: The polymorphism of MTHFR C677T/A1298C may not be an important indicator for the accurate detection of side effects of chemotherapy after using MTX. More relative research is needed. PMID: 30024839 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 20, 2018 Category: Hematology Tags: Hematology Source Type: research

Oxidative stress, antioxidant capacity, biomolecule damage, and inflammation symptoms of sickle cell disease in children.
CONCLUSION: SCD children have high oxidative stress, and conversely, decreased antioxidant activity. Decrease in antioxidant activity might explained the reduction in lipid peroxidation, protein carbonylation and increased inflammation, which in turn intensify the symptoms of SCD in children. PMID: 30010491 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 18, 2018 Category: Hematology Tags: Hematology Source Type: research

Contributions of a regional approach to document hematologic disease in Mexico: a 10-year experience in an open population.
CONCLUSION: Information on hematology diseases derived of regional registries in low-middle income countries is a reasonable alternative to complement and update national registries. PMID: 30010502 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 18, 2018 Category: Hematology Tags: Hematology Source Type: research

Serum chitotriosidase: a circulating biomarker in polycythemia vera.
Authors: Krecak I, Gveric-Krecak V, Roncevic P, Basic-Kinda S, Gulin J, Lapic I, Fumic K, Ilic I, Horvat I, Zadro R, Holik H, Coha B, Peran N, Aurer I, Durakovic N Abstract OBJECTIVES: Serum chitotriosidase activity (CHIT1) is a biomarker of macrophage activation with an important role in inflammation-induced tissue remodeling and fibrosis. Macrophages have been described to play a crucial role in regulating pathological erythropoiesis in polycythemia vera (PV). The aim of this study was to evaluate CHIT1 in patients diagnosed with Philadelphia-negative myeloproliferative neoplasms (MPNs). METHODS: Using fluoro...
Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Polymorphisms in the TGF- β1 (rs1982037) and IL-2 (rs2069762, rs4833248) genes are not associated with inhibitor development in Iranian patients with hemophilia A.
CONCLUSIONS: Regarding our results in molecular predisposition for inhibitor development, further studies of effective genetic markers are required as a prerequisite for the development of novel immunogenic therapeutic approaches in the future. PMID: 29993342 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Mitochondrial ferritin expression in erythroid cells from patients with alpha-thalassaemia.
CONCLUSION: These results suggest that the elevation of expression levels of FTMT in the reticulocytes of patients with alpha-thalassaemia may be associated with iron loading and oxidative stress. PMID: 29993346 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Coexisting driver mutations in MPN: clinical and molecular characteristics of a series of 11 patients.
CONCLUSION: Given the emergence of NGS in clinical practice, more similar cases will be identified in the coming years. The optimal treatment strategy for this rare group of patients is uncertain and toxicity of combination treatment may have to be considered. PMID: 29993347 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Frontline nilotinib treatment in Turkish patients with Philadelphia chromosome-positive chronic Myeloid Leukemia in chronic phase: updated results with 2 years of follow-up.
CONCLUSION: Frontline nilotinib treatment provided sustained efficacy, with good tolerability, over 24 months in newly diagnosed CML-CP patients. PMID: 29996726 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Regulatory T cells and CD20+ B cells in pediatric very severe aplastic anemia: possible clinical markers for evaluating the therapeutic efficacy and prognosis.
Authors: Fang J, Lin L, Wang Y, Lin D, Liu C, Sunlong Q, Lin X Abstract OBJECTIVES: To investigate the immune status of children with very severe aplastic anemia (VSAA), and evaluate the frequencies of CD20+ B cells and Regulatory T cells (Tregs) as potential markers for evaluating the therapeutic efficacy and prognosis. METHODS: We systematically analyzed CD20+ B cells and Tregs using Flow Cytometry in 36 children with VSAA (14 newly diagnosed cases and 22 cases in remission after therapy with HDIVIG + r-ATG + CSA). RESULTS: In newly diagnosed VSAA patients, the percentage of CD...
Source: Hematology - July 13, 2018 Category: Hematology Tags: Hematology Source Type: research

PD-1 blockade potentially enhances adoptive cytotoxic T cell potency in a human acute myeloid leukaemia animal model.
CONCLUSIONS: This finding suggested the potential application of PD-1 blockade in AML. The present work demonstrated an excellent synergistic tumour therapeutic effect of PD-1 blockade and CTL therapy compared with either treatment alone. PMID: 29962321 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - July 3, 2018 Category: Hematology Tags: Hematology Source Type: research

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults and adolescents-a life-threatening disease: analysis of 133 cases from a single center.
CONCLUSION: DEP/L-DEP was a good salvage treatment. L-DEP might be a more effective first-line initial regimen than HLH-94/04 regimen for EBV-HLH. Finally, allo-HSCT is an effective radical treatment for EBV-HLH. PMID: 29957156 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 30, 2018 Category: Hematology Tags: Hematology Source Type: research

Expression analysis of Akirin-2, NF κB-p65 and β-catenin proteins in imatinib resistance of chronic myeloid leukemia.
DISCUSSION: We show for the first time that Akirin-2 can be a novel biomarker in imatinib resistance. Targeting Akirin-2, NFκB and β-catenin genes may provide an opportunity to overcome imatinib resistance in CML. PMID: 29945498 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 29, 2018 Category: Hematology Tags: Hematology Source Type: research

Octamer-binding transcription factor 4 correlates with complex karyotype, FLT3-ITD mutation and poorer risk stratification, and predicts unfavourable prognosis in patients with acute myeloid leukaemia.
Authors: Xiang Y, Zhou X Abstract OBJECTIVE: To investigate the correlation of octamer-binding transcription factor 4 (OCT4) expression with clinicopathological features and its predictive value for treatment response as well as survival profiles in de novo acute myeloid leukaemia (AML) patients. METHOD: One hundred fifty-two de novo AML patients and 52 non-hematologic malignancy patients were recruited in this prospective cohort study. OCT4 expression was determined in bone marrow sample collected before treatment. Complete response (CR), event free survival (EFS) and overall survival (OS) were evaluated. ...
Source: Hematology - June 29, 2018 Category: Hematology Tags: Hematology Source Type: research

The relationship between gene polymorphism of MTRR A66G and lower extremity deep venous thrombosis.
CONCLUSIONS: The gene polymorphism of MTRR A66G may not be an independent genetic risk factor in DVT in China. PMID: 29927730 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 23, 2018 Category: Hematology Tags: Hematology Source Type: research

Hyperferritinemia: causes and significance in a general hospital.
CONCLUSION: Hyperferritinemia is associated with both etiology and the number of underlying causes. PMID: 29914346 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 20, 2018 Category: Hematology Tags: Hematology Source Type: research

Roles of the bone marrow niche in hematopoiesis, leukemogenesis, and chemotherapy resistance in acute myeloid leukemia.
CONCLUSIONS: Interactions between leukemia cells and the bone marrow niche influence hematopoiesis, leukemogenesis, and chemotherapy resistance in AML and require ongoing study. Understanding the mechanisms that underlie these interactions will help identify rational niche-targeting therapies to improve treatment outcomes in AML patients. PMID: 29902132 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 16, 2018 Category: Hematology Tags: Hematology Source Type: research

Impact of interleukin 6 promoter polymorphisms (-174 G   >  C, -572 G  >  C and -597 G  >  A) on plasma IL-6 levels and their influence on the development of DVT: a study from India.
CONCLUSION: Our study emphasizes the importance of -572G > C polymorphism in increasing IL-6 levels, thereby showing its significant role in DVT in India. IL-6 -174G > C and -597G > A were neither associated with raised plasma IL-6 levels nor with thrombotic risk. Thus -572G > C polymorphism detection may be one of the connecting links between IL-6 and thrombotic risk in Indian DVT patients. PMID: 29890913 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Effects of nitric oxide donor S-nitrosoglutathione on apoptosis of apheresis platelets.
CONCLUSION: These data suggest that the addition of a certain dose of GSNO as a NO donor during platelet storage could inhibit platelet apoptosis and reduce platelet storage lesion (PSL) to a certain extent. PMID: 29890936 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Acute myeloid leukemia carrying ETV6 mutations: biologic and clinical features.
DISCUSSION: Future researches are needed to explain how ETV6 mutations act within the microenvironment of leukemic cells and how it affects the progression of leukaemia. PMID: 29894279 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 13, 2018 Category: Hematology Tags: Hematology Source Type: research

Synchronous dual hematological malignancies: new or underreported entity?
CONCLUSION: SDHMs are not uncommon and should be suspected in situations presenting with unusual or unexpected findings. PMID: 29874974 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - June 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Predictive factors of daily opioid use and quality of life in adults with sickle cell disease.
Authors: Karafin MS, Singavi A, Hussain J, Wandersee N, Heinrich T, Hurley RW, Zhang L, Simpson P, Field JJ Abstract OBJECTIVES: In adults with sickle cell disease (SCD), pain often necessitates opioid use. Few studies have examined the relationship between opioid use and health-related quality of life (HRQOL) in adults with SCD. We tested the hypothesis that higher doses of opioids are associated with worse HRQOL. METHODS: A cross-sectional cohort study was performed in adults with SCD who completed standardized and validated HRQOL questionnaires: Patient Health Questionnaire-15 (PHQ-15), Patient Health Questi...
Source: Hematology - June 5, 2018 Category: Hematology Tags: Hematology Source Type: research

Sensorineural hearing loss in children with sickle cell anemia and its association with endothelial dysfunction.
DISCUSSION: SNHL is a common complication in SCA; furthermore, this study identified a significant association between ED and SNHL. Damage to the vascular endothelium because of inflammation in SCA reduced blood flow in the inner ear. Thus, this circulatory disorder culminates in vaso-occlusive process and induces auditory disorders, such as SNHL. PMID: 29806800 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 30, 2018 Category: Hematology Tags: Hematology Source Type: research

Screening of prognostic risk microRNAs for acute myeloid leukemia.
This study aimed to investigate the risk miRNAs (microRNAs) for AML (acute myeloid leukemia) prognosis and related regulatory mechanisms. METHODS: MiRNA and gene expression data, as well as clinical data of 176 patients were first downloaded from TCGA. Then miRNAs and genes significantly affecting the survival time based on KM survival curve were identified using Log Rank test. Next, COX proportional-hazard regression analysis was performed to screen the risk miRNAs (P-value 1 or
Source: Hematology - May 24, 2018 Category: Hematology Tags: Hematology Source Type: research

The clinical characteristics and therapy response of patients with acquired pure red cell aplasia.
Authors: Fu R, Zhang T, Liu B, Song J, Wang G, Li L, Wang H, Xing L, Wu Y, Guan J, Shao Z Abstract OBJECTIVE: To summarize the clinical characteristics of acquired pure red cell aplasia (PRCA) patients diagnosed in our hospital in the last 10 years. METHOD: The clinical features, immune state and treatment response of acquired PRCA patients diagnosed in our hospital from January 2007 to January 2017 were retrospectively analyzed. RESULTS: The results showed that thymoma (13.21%) and parvovirus B19 (11.32%) were the most common causes for secondary PRCA. Ferritin (Fer) levels and erythropoietin (EPO) levels ...
Source: Hematology - May 16, 2018 Category: Hematology Tags: Hematology Source Type: research

Prognostic significance of SRSF2 mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia: a meta-analysis.
CONCLUSION: In conclusion, SRSF2 mutations were significantly related to the shorter OS in patients with MDS which may consider as an adverse prognostic risk factor. Whereas, analysis did not show any prognostic effect on OS of CMML patients with SRSF2 mutations. PMID: 29757120 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 16, 2018 Category: Hematology Tags: Hematology Source Type: research

Characteristics of fibrinolytic disorders in acute promyelocytic leukemia.
CONCLUSIONS: In APL, activated coagulation system activated fibrinolytic system, and increased uPAR levels could contribute to the hyperfibrinolysis. Annexin II might not be involved in the coagulopathy. PMID: 29724147 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - May 9, 2018 Category: Hematology Tags: Hematology Source Type: research

Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study.
CONCLUSION: A high prevalence of iron overload in this patient population in Latin American countries indicates that a better diagnosis and management of iron overload is required in these countries. PMID: 29663858 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 19, 2018 Category: Hematology Tags: Hematology Source Type: research

Geographical distribution of β-globin gene mutations in Syria.
Conclusions These data will significantly facilitate the population screening, genetic counseling and prenatal diagnosis in Syrian population. PMID: 29637841 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 14, 2018 Category: Hematology Tags: Hematology Source Type: research

Iron deficiency anemia referral to the hematologist. Real-world data from Mexico: the need for targeted teaching in primary care.
Authors: López-García YK, Colunga-Pedraza PR, Tarín-Arzaga L, López Garza MI, Jaime-Pérez JC, Gómez-Almaguer D Abstract OBJECTIVES: To determine the referral patterns and etiology of iron deficiency anemia (IDA) at an academic hematology center in northeast Mexico. METHODS: We included all consecutive outpatients older than 16 years, non-pregnant, with IDA diagnosed in the Hematology Service of the Dr. José E. González University Hospital between January 2012 and May 2017. Appropriate data were collected retrospectively from the electronic medical rec...
Source: Hematology - April 14, 2018 Category: Hematology Tags: Hematology Source Type: research

Mean platelet volume at baseline and immune thrombocytopenia relapse in Chinese newly-diagnosed patients: a retrospective cohort study.
Conclusion The relationship between MPV and ITP relapse is non-linear. MPV is an independent risk factor of ITP relapse when MPV is less than 21 fl. PMID: 29633664 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 12, 2018 Category: Hematology Tags: Hematology Source Type: research

Contrasting co-inheritance of alpha and beta mutations in delta beta thalassemia and hereditary persistence of fetal hemoglobin: a study from India.
CONCLUSION: We found 5/18(27.β) δβ-thalassemia cases with co-inherited alpha 3.7 deletion and 3/18 (16β) cases with IVS 1-5(G-C) mutation. Patients showed features of thalassemia intermedia phenotype among which those with co-inherited IVS 1-5(G-C) mutation showed severe phenotype as compared to those with co-inherited alpha 3.7 deletion. So, we highlight importance of genotyping of patients with δβ thalassemia or HPFH and coinheritance with inherited factors which plays crucial role in clinicopathological profile and setting up prenatal diagnostic protocol. PMID: 29621931 [PubMed - as s...
Source: Hematology - April 7, 2018 Category: Hematology Tags: Hematology Source Type: research

Analysis of erythrocyte membrane proteins in patients with hereditary spherocytosis and other types of haemolytic anaemia.
CONCLUSION: Haemolysis in patients with HS occurred because the fragile proteins in erythrocytes (band 3, spectrin, and ankyrin) collapsed due to compression during blood circulation in the spleen. Further, haemolysis in patients with haemoglobinopathy occurred owing to membrane damage due to combined spectrin, band 3 with denatured haemoglobin in the vessel during blood circulation. PMID: 29623813 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 7, 2018 Category: Hematology Tags: Hematology Source Type: research

Humoral immune response of childhood acute lymphoblastic leukemia survivors against the measles, mumps, and rubella vaccination.
CONCLUSION: We suggest the need for booster MMR vaccination, especially for ALL children under the age of 5 years and those who experienced a protracted time interval post-treatment. PMID: 29614919 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - April 6, 2018 Category: Hematology Tags: Hematology Source Type: research

Sequence typing of human adenoviruses isolated from Polish patients subjected to allogeneic hematopoietic stem cell transplantation - a single center experience.
CONCLUSIONS: The predominance of HAdV-C and common presence of anti-HAdV antibodies in IgG class may strongly suggest that most infections in the present study were reactivations of HAdV persisting into the patient's mucosa-associated lymphoid tissues. Variability of HAdV sequences suggests that cross-infections between patients were very rare. ABBREVIATIONS: GvHD: graft-versus-host disease; HAdV: human adenoviruses; HSCT: hematopoietic stem cell transplantation. PMID: 29591536 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 31, 2018 Category: Hematology Tags: Hematology Source Type: research

Modifying factors of the health belief model associated with missed clinic appointments among individuals with sickle cell disease.
CONCLUSIONS: Our findings demonstrate that modifying components of the Health Belief Model, including age, financial security, health literacy, spirituality, and lacking cues to action like reminders, are important in missed appointments and addressing these factors could improve appointment-keeping for adults and children with SCD. PMID: 29595096 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 31, 2018 Category: Hematology Tags: Hematology Source Type: research

Health-related quality of life before and after hematopoietic stem cell transplant: evidence from a survey in Suzhou, China.
Authors: Liang Y, Wang H, Niu M, Zhu X, Cai J, Wang X Abstract OBJECTIVES: The aim of our longitudinal study was to explore changes in HRQOL over a 6-month period and to identify factors associated with the HRQOL of HSCT recipients. METHOD: Our study comprised 191 HSCT patients; their data were collected before transplantation and at 30, 90, and 180 days posttransplantation. The Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) questionnaire was used to assess HRQOL.We also evaluated the patients' demographic characteristics and clinical histories to determine the relative contributions ...
Source: Hematology - March 30, 2018 Category: Hematology Tags: Hematology Source Type: research

ISH Newsletter.
Authors: PMID: 29576003 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children.
Authors: Sezer RG, Akoğlu HA, Bozaykut A, Özdemir GN Abstract OBJECTIVE: Although, oral replacement for vitamin B12 deficiency has been proved to be effective in adults, it is mainly treated with parenteral therapy. There are only few studies on oral replacement therapy of vitamin B12 with children. Therefore, we aimed to compare the efficacy of oral treatment with intramuscular vitamin B12 injections in pediatric population. METHODS: Children with serum cobalamin concentrations less than 300 pg/mL, were treated either with the parenteral therapy or with oral vitamin B12. The primary and secondary outco...
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Statement of Retraction.
Authors: PMID: 29578377 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Comparative assessment of prophylactic transfusions of platelet concentrates obtained by the PRP or buffy-coat methods, in patients undergoing allogeneic hematopoietic stem cell transplantation.
Authors: Fernández-Muñoz H, Plaza EM, Rivera-Caravaca JM, Candela MJ, Romera M, De Arriba F, Lozano ML, Vicente V, Heras I, Castilla-Llorente C, Rivera J Abstract OBJECTIVES: Whole blood-derived platelet concentrates can be obtained by the platelet-rich plasma (PRP-PCs) or the buffy-coat (BC-PCs) method. Few studies have shown that BC-PCs display lower in vitro platelet activation, but scarce information exists regarding transfusion efficacy. We have performed a retrospective study assessing platelet transfusion in patients undergoing allogeneic hematopoietic cell transplantation (AHCT) in our clinic,...
Source: Hematology - March 28, 2018 Category: Hematology Tags: Hematology Source Type: research

Synergistic effects of rmhTRAIL and 17-AAG on the proliferation and apoptosis of multiple myeloma cells.
CONCLUSION: The combined application of rmhTRAIL and 17-AAG revealed favorable synergistic effects in the treatment of MM. PMID: 29566599 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 24, 2018 Category: Hematology Tags: Hematology Source Type: research

Evaluation of hypercoagulability with rotational thromboelastometry in children with iron deficiency anemia.
This study conforms to ethical standards, has been approved by the appropriate Institutional Review Board. RESULTS: Hemoglobin, serum iron, transferrin saturation and ferritin levels were lower in the IDA group than in the control group (p  0.05). The EXTEM and INTEM MCF in the IDA group was higher than in the control group, while the INTEM CFT and rate of ML60% were lower than in the control group (p 
Source: Hematology - March 20, 2018 Category: Hematology Tags: Hematology Source Type: research

Calreticulin mutation analysis in non-mutated Janus kinase 2 essential thrombocythemia patients in Chiang Mai University: analysis of three methods and clinical correlations.
CONCLUSIONS: The prevalence of CALR mutation in JAK2V617F-negative ET in this study is 35.7%. HRM is an effective method of detecting CALR mutation and is a more advantageous method of screening for CALR mutation. PMID: 29521158 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 11, 2018 Category: Hematology Tags: Hematology Source Type: research

Causes of microcytic anaemia and evaluation of conventional laboratory parameters in the differentiation of erythrocytic microcytosis in blood donors candidates.
CONCLUSIONS: This study showed that the values of haematological parameters, especially haematocrit, Hb, MCV, MCH, MCHC and red blood cell distribution width (RDW), are lower in patients with IDA, especially when associated with α-thal and therefore it may be useful to discriminate between the different types of microcytic anaemia. PMID: 29521164 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 11, 2018 Category: Hematology Tags: Hematology Source Type: research

Impact on acute myeloid leukemia relapse in granulocyte colony-stimulating factor application: a meta-analysis.
DISCUSSION: Treatment with chemotherapy plus G-CSF appears to provide better survival and treatment responses compared with chemotherapy alone, particularly for patients with previously untreated AML. ABBREVIATIONS: AML, acute myeloid leukemia; CI, confidence interval; CR, complete remission; DFS, disease-free survival; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte macrophage colony-stimulating factor; HR, hazard ratio; MDS, myelodysplastic syndrome; OR, odds ratio; OS, overall survival; RCTs, randomized control trials; RR, relative risk. PMID: 29516766 [PubMed - as supplied by publisher] (Source: Hematology)
Source: Hematology - March 10, 2018 Category: Hematology Tags: Hematology Source Type: research