High Expression of WT1 and Low Expression of p53 in Archived Blocks of Children with Wilms Tumor in South Western Uganda
(Source: Cancer Management and Research)
Source: Cancer Management and Research - March 6, 2024 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor- β receptor type 2 axis
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):143-149. doi: 10.14715/cmb/2024.70.2.20.ABSTRACTTo explore the action and mechanism in which circular RNA (circRNA) mitofusin 2 (MFN2) repressed the malignant proliferation of Wilms tumor (WT) via modulating microRNA (miR)-372-3p/transforming growth factor-β receptor type 2 (TGFBR2) axis. CircRNA MFN2 was distinctly elevated in the tissues and cells of WT patients, while miR-372-3p was silenced in the tissues and cells of WT. Test of TGFBR2, PCNA and Bax was implemented. Transfection with si-circRNA MFN2 or miR-372-3p-mimic restrained cancer cell advancement and the number...
Source: Mol Biol Cell - March 2, 2024 Category: Molecular Biology Authors: Maolin Xiao Xiaofeng Pu Wei Tong Xiao Xiao Source Type: research
Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor- β receptor type 2 axis
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):143-149. doi: 10.14715/cmb/2024.70.2.20.ABSTRACTTo explore the action and mechanism in which circular RNA (circRNA) mitofusin 2 (MFN2) repressed the malignant proliferation of Wilms tumor (WT) via modulating microRNA (miR)-372-3p/transforming growth factor-β receptor type 2 (TGFBR2) axis. CircRNA MFN2 was distinctly elevated in the tissues and cells of WT patients, while miR-372-3p was silenced in the tissues and cells of WT. Test of TGFBR2, PCNA and Bax was implemented. Transfection with si-circRNA MFN2 or miR-372-3p-mimic restrained cancer cell advancement and the number...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Maolin Xiao Xiaofeng Pu Wei Tong Xiao Xiao Source Type: research
Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor- β receptor type 2 axis
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):143-149. doi: 10.14715/cmb/2024.70.2.20.ABSTRACTTo explore the action and mechanism in which circular RNA (circRNA) mitofusin 2 (MFN2) repressed the malignant proliferation of Wilms tumor (WT) via modulating microRNA (miR)-372-3p/transforming growth factor-β receptor type 2 (TGFBR2) axis. CircRNA MFN2 was distinctly elevated in the tissues and cells of WT patients, while miR-372-3p was silenced in the tissues and cells of WT. Test of TGFBR2, PCNA and Bax was implemented. Transfection with si-circRNA MFN2 or miR-372-3p-mimic restrained cancer cell advancement and the number...
Source: Mol Biol Cell - March 2, 2024 Category: Molecular Biology Authors: Maolin Xiao Xiaofeng Pu Wei Tong Xiao Xiao Source Type: research
Prognostic role of primary tumor size in Wilms tumor
Oncol Lett. 2024 Feb 19;27(4):164. doi: 10.3892/ol.2024.14297. eCollection 2024 Apr.ABSTRACTWilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the optimal cut-off value of primary tumor size. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Mei...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Kai Li Ke Zhang Hexing Yuan Caibin Fan Source Type: research
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination
CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.PMID:38427208 | DOI:10.1007/s12185-024-03723-1 (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 1, 2024 Category: Hematology Authors: Tatsuya Suwabe Yasuhiko Shibasaki Suguru Tamura Takayuki Katagiri Kyoko Fuse Tori Ida-Kurasaki Takashi Ushiki Hirohito Sone Miwako Narita Masayoshi Masuko Source Type: research
Prognostic role of primary tumor size in Wilms tumor
Oncol Lett. 2024 Feb 19;27(4):164. doi: 10.3892/ol.2024.14297. eCollection 2024 Apr.ABSTRACTWilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the optimal cut-off value of primary tumor size. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Mei...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Kai Li Ke Zhang Hexing Yuan Caibin Fan Source Type: research
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination
CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.PMID:38427208 | DOI:10.1007/s12185-024-03723-1 (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 1, 2024 Category: Hematology Authors: Tatsuya Suwabe Yasuhiko Shibasaki Suguru Tamura Takayuki Katagiri Kyoko Fuse Tori Ida-Kurasaki Takashi Ushiki Hirohito Sone Miwako Narita Masayoshi Masuko Source Type: research
Prognostic role of primary tumor size in Wilms tumor
Oncol Lett. 2024 Feb 19;27(4):164. doi: 10.3892/ol.2024.14297. eCollection 2024 Apr.ABSTRACTWilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the optimal cut-off value of primary tumor size. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Mei...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Kai Li Ke Zhang Hexing Yuan Caibin Fan Source Type: research
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination
CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.PMID:38427208 | DOI:10.1007/s12185-024-03723-1 (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 1, 2024 Category: Hematology Authors: Tatsuya Suwabe Yasuhiko Shibasaki Suguru Tamura Takayuki Katagiri Kyoko Fuse Tori Ida-Kurasaki Takashi Ushiki Hirohito Sone Miwako Narita Masayoshi Masuko Source Type: research
Prognostic role of primary tumor size in Wilms tumor
Oncol Lett. 2024 Feb 19;27(4):164. doi: 10.3892/ol.2024.14297. eCollection 2024 Apr.ABSTRACTWilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the optimal cut-off value of primary tumor size. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Mei...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Kai Li Ke Zhang Hexing Yuan Caibin Fan Source Type: research
Decade-long WT1-specific CTLs induced by WT1 peptide vaccination
CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.PMID:38427208 | DOI:10.1007/s12185-024-03723-1 (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 1, 2024 Category: Hematology Authors: Tatsuya Suwabe Yasuhiko Shibasaki Suguru Tamura Takayuki Katagiri Kyoko Fuse Tori Ida-Kurasaki Takashi Ushiki Hirohito Sone Miwako Narita Masayoshi Masuko Source Type: research
Prognostic role of primary tumor size in Wilms tumor
Oncol Lett. 2024 Feb 19;27(4):164. doi: 10.3892/ol.2024.14297. eCollection 2024 Apr.ABSTRACTWilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the optimal cut-off value of primary tumor size. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Mei...
Source: Oncology Letters - March 1, 2024 Category: Cancer & Oncology Authors: Kai Li Ke Zhang Hexing Yuan Caibin Fan Source Type: research
Identification and Validation of Lipid Metabolism Gene FASN-Associated miRNA in Wilms Tumor
This study intends to explore the role of miRNA in the lipid metabolism and development of Wilms tumor (WT) by detecting and analyzing the differences in the expression profiles of miRNAs between the tumor and adjacent normal tissue. Gene detection was performed in tumor tissues and adjacent normal tissues of three cases of WT to screen differentially expressed miRNAs (DEMs). According to our previous research, FASN, which participates in the lipid metabolism pathway, may be a target of WT. The starBase database was used to predict FASN-targeted miRNAs. The above two groups of miRNAs were intersected to obtain FASN-targete...
Source: Biochemical Genetics - February 28, 2024 Category: Genetics & Stem Cells Authors: Xiaoqing Wang Xiao Li Lin Tan Fengjun Zhang Jing Zhang Xu Zhao Yongfei Zhang Guoqiang Du Wei Liu Source Type: research
Identification and Validation of Lipid Metabolism Gene FASN-Associated miRNA in Wilms Tumor
This study intends to explore the role of miRNA in the lipid metabolism and development of Wilms tumor (WT) by detecting and analyzing the differences in the expression profiles of miRNAs between the tumor and adjacent normal tissue. Gene detection was performed in tumor tissues and adjacent normal tissues of three cases of WT to screen differentially expressed miRNAs (DEMs). According to our previous research, FASN, which participates in the lipid metabolism pathway, may be a target of WT. The starBase database was used to predict FASN-targeted miRNAs. The above two groups of miRNAs were intersected to obtain FASN-targete...
Source: Biochemical Genetics - February 28, 2024 Category: Genetics & Stem Cells Authors: Xiaoqing Wang Xiao Li Lin Tan Fengjun Zhang Jing Zhang Xu Zhao Yongfei Zhang Guoqiang Du Wei Liu Source Type: research
