Correction to: Measurable residual disease after the first consolidation predicts the outcomes of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy.
Abstract In the original publication of the article, the "CNS involvement" in the last row under the column "Total N=50" has been published incorrectly. The correct Table 1 is given in this correction. PMID: 32643074 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - July 8, 2020 Category: Hematology Authors: Henzan H, Takase K, Kamimura T, Mori Y, Yoshimoto G, Iwasaki H, Nagafuji K, Ogawa R, Eto T, Uchida N, Fujisaki T, Kato K, Minami M, Kikushige Y, Akashi K, Miyamoto T, Fukuoka Blood & Marrow Transplantation Group (FBMTG) Tags: Int J Hematol Source Type: research

New insights on patient-related risk factors for venous thromboembolism in patients with solid organ cancers.
In conclusion, chronic pulmonary disease and obesity increase VTE hospitalization risk in patients with and without cancer and the risk decreases in cancer patients with liver disease, CKD or ESRD. PMID: 32632822 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - July 6, 2020 Category: Hematology Authors: Kotecha A, Raghavan D, Yadav SK, A Sule A, Arsene C Tags: Int J Hematol Source Type: research

Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma.
Abstract Duvelisib is a novel dual inhibitor of phosphoinositide-3-kinase (PI3K)-δ and -γ. This single-arm, multicenter phase I study investigated its safety, pharmacokinetics, and preliminary efficacy in Japanese patients with relapsed or refractory lymphoma. Duvelisib was administered orally twice daily at 25 mg in 28-day cycles. Seven patients, comprising 4 with follicular lymphoma (FL), 2 with diffuse large B-cell lymphoma, and 1 with mantle cell lymphoma (MCL) were enrolled. No dose-limiting toxicity occurred in any patient. The most commonly experienced treatment-related adverse events of an...
Source: International Journal of Hematology - July 1, 2020 Category: Hematology Authors: Izutsu K, Kato K, Kiyoi H, Yamamoto G, Shimada K, Akashi K Tags: Int J Hematol Source Type: research

Severe immune thrombocytopenic purpura in critical COVID-19.
We report herein a case of severe immune thrombocytopenic purpura (ITP) in a critical COVID-19 patient. A patient presented a severe episode of immune thrombocytopenia (
Source: International Journal of Hematology - July 1, 2020 Category: Hematology Authors: Lévesque V, Millaire É, Corsilli D, Rioux-Massé B, Carrier FM Tags: Int J Hematol Source Type: research

Demographic characteristics, thromboembolism risk, and treatment patterns for patients with cold agglutinin disease in Japan.
Abstract Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan. Patients with CAD (at least three claims with a CAD diagnosis; Japanese Disease Code 2830009) and non-CAD controls were retrospectively identified (2008-2017) from a large hospital-based administrative claims dataset in Japan. Cohorts were compared using conditional logistic regression. We i...
Source: International Journal of Hematology - June 30, 2020 Category: Hematology Authors: Kamesaki T, Nishimura JI, Wada H, Yu E, Tsao E, Morales J, Kanakura Y Tags: Int J Hematol Source Type: research

Correction to: Histologic transformation of t(11;18)-positive MALT lymphoma presented with aberrant T-cell marker expression.
Abstract M. Nishikori receives honoraria from Eisai and funding from Eisai and Sumitomo Dainippon Pharmaceutical. PMID: 32596795 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 28, 2020 Category: Hematology Authors: Tamura N, Maeda H, Nishikori M, Fujita H, Hishizawa M, Haga H, Takaori-Kondo A Tags: Int J Hematol Source Type: research

Next-generation CAR T cells to overcome current drawbacks.
Abstract As a rapidly emerging treatment in the oncology field, adoptive transfer of autologous, genetically modified chimeric antigen receptor (CAR) T cells has shown striking efficacy and is curative in certain relapsed/refractory patients with hematologic malignancy. This treatment modality of using a "living drug" offers many tantalizing and novel therapeutic strategies for cancer patients whose remaining treatment options may have otherwise been limited. Despite the early success of CAR T cells in hematologic malignancies, many barriers remain for widespread adoption. General barriers include cellul...
Source: International Journal of Hematology - June 27, 2020 Category: Hematology Authors: Lundh S, Maji S, Melenhorst JJ Tags: Int J Hematol Source Type: research

High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity.
We examined the association between serum ferritin (SF) levels and patient-reported functional aspects and symptoms, as measured by the EORTC QLQ-C30, in newly diagnosed patients with myelodysplastic syndromes (MDS). Analysis was conducted on 497 MDS patients who were classified in two groups based on the SF value of 1000 ng/mL. Clinically relevant differences of patient-reported functional and symptom scales were evaluated and classified as small, medium and large, based on established thresholds. Multivariable linear regression analysis was performed to account for potential confounding factors. Patients with SF of&...
Source: International Journal of Hematology - June 25, 2020 Category: Hematology Authors: Caocci G, Vignetti M, Patriarca A, Breccia M, Platzbecker U, Palumbo GA, Stauder R, Cottone F, Petranovic D, Voso MT, Tafuri A, Invernizzi R, Caers J, Luppi M, La Nasa G, Niscola P, Efficace F Tags: Int J Hematol Source Type: research

Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group.
Abstract Programmed death 1 ligand (PD-L1) is an immunomodulatory molecule expressed by cancer cells, and it has been widely demonstrated to inhibit host antitumor responses. The aim of the present study was to identify clinicopathological features associated with PD-L1 expression in the secondary solid cancers of patients after allogeneic hematopoietic stem cell transplantation. In this database of 530 patients who received allo-HSCT between 1990 and 2017, 15 developed solid cancers with a median interval of 3487 days after transplantation. Three patients had 2 different solid cancers. Eighteen solid cancer ...
Source: International Journal of Hematology - June 25, 2020 Category: Hematology Authors: Kasai S, Itonaga H, Niino D, Miyoshi H, Kato T, Imanishi D, Fujioka M, Furumoto T, Sato S, Sawayama Y, Taguchi J, Imaizumi Y, Hata T, Yoshida S, Moriuchi Y, Ohshima K, Miyazaki Y Tags: Int J Hematol Source Type: research

Potential role of Howell-Jolly bodies in identifying functional hyposplenism: a prospective single-institute study.
Abstract Although patients with cancer and immunosuppression are at a risk of functional hyposplenism, how to detect it promptly remains unclear. Since hyposplenism allows erythrocytes with nuclear remnants (Howell-Jolly bodies [HJBs]) to appear in the peripheral blood, HJB detection by a routine microscopic examination may help identify patients with functional hyposplenism. This prospective study was thus performed to determine the underlying diseases in patients who presented with HJBs. Of 100 consecutive patients presenting with HJBs, 73 had a history of splenectomy. The remaining 27 had hematologic cancer (n&...
Source: International Journal of Hematology - June 23, 2020 Category: Hematology Authors: Nakagami Y, Uchino K, Okada H, Suzuki K, Enomoto M, Mizuno S, Yamamoto H, Hanamura I, Nakayama T, Tani H, Takami A Tags: Int J Hematol Source Type: research

Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells.
Abstract Vitamin K2 in the form of menatetrenone has clinical benefits for osteoporosis and cytopenia. Given the dominant role of mesenchymal-osteolineage cells in the regulation of hematopoiesis, we investigated whether menatetrenone alters the hematopoiesis-supportive capability of human bone marrow mesenchymal stromal/stem cells (BM-MSCs). Menatetrenone up-regulated fibronectin protein expression in BM-MSCs without affecting their proliferation and differentiation capabilities. In addition, menatetrenone treatment of BM-MSCs enhanced generation of the CD34+ cell population in co-cultures through acceleration of...
Source: International Journal of Hematology - June 22, 2020 Category: Hematology Authors: Fujishiro A, Iwasa M, Fujii S, Maekawa T, Andoh A, Tohyama K, Takaori-Kondo A, Miura Y Tags: Int J Hematol Source Type: research

Diagnosis of a difficult to differentiate case of early-onset hyperviscosity syndrome caused by IgM type multiple myeloma: a case report.
Abstract Hyperviscosity syndrome (HVS) can cause multiple organ damage if not treated immediately. IgM multiple myeloma (IgM MM) is a very rare form of myeloma with clinical features such as elevated serum IgM, and anemia, that resemble Waldenström macroglobulinemia (WM). Distinguishing between these two diseases is important, but can be a challenging problem. It is well known that MyD88 mutations and t(11;14) translocations are useful for differential diagnosis. We diagnosed HVS in a 29-year-old male with IgM MM. He was treated with triplet therapy, autologous hematopoietic stem cell transplantation, and car...
Source: International Journal of Hematology - June 22, 2020 Category: Hematology Authors: Yoshimura T, Hayashi Y, Shimizu K, Yagi N, Tsutsumi M, Nakaya Y, Fuseya H, Horiuchi M, Yoshida M, Nakao T, Inoue T, Yamane T Tags: Int J Hematol Source Type: research

A phase 1b study of blinatumomab in Japanese children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.
Abstract Novel therapies are needed for children with relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukemia (ALL). Blinatumomab is a bispecific T-cell engager immunotherapy that simultaneously binds to CD3-positive cytotoxic T cells and CD19-positive B cells and redirects the patient's T cells to lyse malignant and normal B cells. We conducted an open-label phase 1b study to determine the safety, pharmacokinetics, efficacy, and recommended dose of blinatumomab in Japanese children with R/R B-cell precursor ALL. Patients received induction blinatumomab for 4 weeks (5 μg/m2/day week 1;...
Source: International Journal of Hematology - June 20, 2020 Category: Hematology Authors: Horibe K, Morris JD, Tuglus CA, Dos Santos C, Kalabus J, Anderson A, Goto H, Ogawa C Tags: Int J Hematol Source Type: research

Comparison of molecular structure and fibrin polymerization between two B β-chain N-terminal region fibrinogen variants, Bβp.G45C and Bβp.R74C.
Comparison of molecular structure and fibrin polymerization between two Bβ-chain N-terminal region fibrinogen variants, Bβp.G45C and Bβp.R74C. Int J Hematol. 2020 Jun 19;: Authors: Kaido T, Yoda M, Kamijo T, Taira C, Higuchi Y, Okumura N Abstract We identified two heterozygous dysfibrinogenemias, Bβp.Gly45Cys (Kyoto VII; K-VII) and Bβp.Arg74Cys (Iida II; I-II). The impairment of polymerization of Bβp.G45C has been well analyzed; however, that of Bβp.R74C has not. Thus, we compared fibrin polymerization between these variants. To determine the structural and functiona...
Source: International Journal of Hematology - June 19, 2020 Category: Hematology Authors: Kaido T, Yoda M, Kamijo T, Taira C, Higuchi Y, Okumura N Tags: Int J Hematol Source Type: research

An interesting case of thrombocytopenia in pregnancy.
PMID: 32557127 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 19, 2020 Category: Hematology Authors: Garcia-Horton A, Chin-Yee I, Lam S Tags: Int J Hematol Source Type: research

Real-world management of infection during chemotherapy for acute leukemia in Japan: from the results of a nationwide questionnaire-based survey by the Japan Adult Leukemia Study Group.
In conclusion, this study clarified the real-world management of infection during intensive chemotherapy for acute leukemia in 2019 and raised future issues in Japan. PMID: 32557124 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 18, 2020 Category: Hematology Authors: Kimura SI, Fujita H, Handa H, Hiramoto N, Hosono N, Minamiguchi H, Takahashi T, Kato H, Ono T, Kanda Y, Kiyoi H, Matsumura I, Miyazaki Y, Japan Adult Leukemia Study Group (JALSG) Tags: Int J Hematol Source Type: research

Pathological findings suggesting vascular endothelial damage in multiple organs in chronic myelogenous leukemia patients on long-term tyrosine kinase inhibitor therapy.
Abstract A 66-year-old man with hypertension was diagnosed with chronic myelogenous leukemia in 1996. Treatment was started with hydroxycarbamide and imatinib 400 mg in 1996 + 6, which was increased to 600 mg. Although he achieved a complete cytogenic response in 1996 + 9, he could not continue imatinib because of edema; the regimen was changed to nilotinib 800 mg in 1996 + 13. After he achieved a molecular response better than 4.5 in 1996 + 19, he was referred to our hospital. His urinalysis had shown urine protein since 1996 + 1...
Source: International Journal of Hematology - June 18, 2020 Category: Hematology Authors: Seki Y, Nagano O, Koda R, Morita S, Hasegawa G Tags: Int J Hematol Source Type: research

Eltrombopag to allow chemotherapy in a patient with MYH9-related inherited thrombocytopenia and pancreatic cancer.
We report the first successful use of eltrombopag to prevent chemotherapy-induced thrombocytopenia in a patient with MHY9-related disorder and pancreatic cancer. Treatment with eltrombopag allowed to attain a safe and stable platelet count for several months sufficient to permit chemotherapy and to allow the patient to undergo endoscopic placement of a biliary stent with no bleeding complications. PMID: 32557126 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 18, 2020 Category: Hematology Authors: Paciullo F, Bury L, Gresele P Tags: Int J Hematol Source Type: research

The human spleen as the center of the blood defense system.
Abstract Blood-borne infections can develop into sepsis and are therefore a major human health risk. The responsible pathogens thus need to be eliminated rapidly. Intravascular macrophages in the liver and bone marrow (BM) sinuses, and in the red pulp and marginal zone of the spleen, remove the majority of these microorganisms via innate immunity. However, specific antibodies are essential for their complete elimination. Splenic marginal zone B cells simultaneously produce many of the IgM and IgG2 antibodies that target blood-borne pathogens within a few days of infection. Subsequently, follicular B cells of the w...
Source: International Journal of Hematology - June 16, 2020 Category: Hematology Authors: Kashimura M Tags: Int J Hematol Source Type: research

Genomic characterization and prognostication applied to a Brazilian cohort of patients with myelofibrosis.
Abstract Genomic characterization of patients with myeloproliferative neoplasms (MPN) may lead to better diagnostic classification, prognostic assessment, and treatment decisions. These goals are particularly important in myelofibrosis (MF). We performed target Next Generation Sequencing for a panel of 255 genes and Chromosome Microarray Analysis (CMA) in 27 patients with MF. Patients were classified according to genomic findings and we compared the performance of a personalized prognostication system with IPSS, MIPSS70 and MIPSS70 + v2. Twenty-six patients presented mutations: 11.1% had single drive...
Source: International Journal of Hematology - June 13, 2020 Category: Hematology Authors: Nonino A, Campregher PV, de Souza Santos FP, Mazzeu JF, Pereira RW Tags: Int J Hematol Source Type: research

Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator.
Abstract The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) protein family members have cytidine deaminase activity and can induce cytosine to uracil transition in nucleic acid. The main function of APOBEC3 (A3) proteins is to trigger an innate immune response to viral infections. Recent reports have shown that several APOBEC family proteins such as A3B can induce somatic mutations into genomic DNA and thus promote cancer development. However, the role of A3D on somatic mutations is unclear. Here, we identified the alternative splicing of A3D, and investigated each splice variant's subcel...
Source: International Journal of Hematology - June 12, 2020 Category: Hematology Authors: Takei H, Fukuda H, Pan G, Yamazaki H, Matsumoto T, Kazuma Y, Fujii M, Nakayama S, Kobayashi IS, Shindo K, Yamashita R, Shirakawa K, Takaori-Kondo A, Kobayashi SS Tags: Int J Hematol Source Type: research

Vascular events may predict the prognosis of patients with chronic myeloid leukemia.
PMID: 32533516 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2020 Category: Hematology Authors: Ureshino H, Kamachi K Tags: Int J Hematol Source Type: research

A case of human herpesvirus 6 encephalitis following pediatric hematopoietic stem cell transplantation: early diagnosis and treatment matters.
We report a pediatric HSCT recipient who developed late-onset HHV-6 encephalitis without typical radiographic findings. The routine viral infection monitoring protocol contributed to the prompt diagnosis of HHV-6 encephalitis and early therapeutic intervention. The patient was treated successfully without any neurological complications attributable to HHV-6 encephalitis. HHV-6 encephalitis should remain in the differential diagnosis as an important but treatable disease, even for several months after HSCT and even without radiographic findings. Whenever HHV-6 encephalitis is suspected, antivirals should be initiated prompt...
Source: International Journal of Hematology - June 11, 2020 Category: Hematology Authors: Sakamoto A, Yamada M, Tsujimoto SI, Osumi T, Arai K, Tomizawa D, Ishiguro A, Matsumoto K, Imadome KI, Kato M Tags: Int J Hematol Source Type: research

HHV8-positive, EBV-positive Hodgkin lymphoma-like large B cell lymphoma: expanding the spectrum of HHV8 and EBV-associated lymphoproliferative disorders.
We describe the case of a 64-year-old male, without known immunodeficiency, with 1-year-long clinical history of mediastinal and abdominal lymphadenopathies and recurrent pulmonary infections. Histopathological evaluation of a mediastinal lymph node revealed the presence of scattered atypical large cells with Hodgkin and Reed-Sternberg morphology in a background of lymphocytes and extensive areas of fibrosis. The large cells were positive for HHV8 and Epstein-Barr virus (EBV), with a clonal pattern of IGH gene rearrangement. A descriptive diagnosis of "HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lym...
Source: International Journal of Hematology - June 11, 2020 Category: Hematology Authors: Sanchez S, Veloza L, Wang L, López M, López-Guillermo A, Marginet M, Martínez A, Balagué O, Campo E Tags: Int J Hematol Source Type: research

Impact of prednisolone dosage in the CHOP regimen for follicular lymphoma: a retrospective study.
In conclusion, the PSL dose adjusted based on body surface area appeared to be appropriate in terms of efficacy and safety. PMID: 32529585 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 11, 2020 Category: Hematology Authors: Ikeda T, Fujiwara SI, Nakajima H, Kawaguchi SI, Toda Y, Ito S, Ochi S, Nagayama T, Mashima K, Umino K, Minakata D, Nakano H, Morita K, Yamasaki R, Kawasaki Y, Ashizawa M, Yamamoto C, Hatano K, Sato K, Oh I, Ohmine K, Muroi K, Kanda Y Tags: Int J Hematol Source Type: research

Elevated C-reactive protein level is associated with poor prognosis in follicular lymphoma patients undergoing rituximab-containing chemotherapy.
Abstract Although follicular lymphoma (FL) is a pathological entity characterized by relatively uniform histological and molecular findings, its clinical course is highly variable. Establishment of therapeutic strategies based on a simple and practical prognostic model is important. C-reactive protein (CRP) is an adverse prognostic marker for various tumors and aggressive lymphomas. However, the significance of serum CRP levels as a prognostic index in low-grade lymphomas, such as FL, has not been thoroughly investigated. We retrospectively analyzed the relationship between serum CRP levels at diagnosis and the pr...
Source: International Journal of Hematology - June 10, 2020 Category: Hematology Authors: Kawaguchi Y, Saito B, Nakata A, Matsui T, Sasaki Y, Shimada S, Abe M, Watanuki M, Baba Y, Murai S, Arai N, Fujiwara S, Kabasawa N, Tsukamoto H, Uto Y, Yanagisawa K, Hattori N, Harada H, Nakamaki T Tags: Int J Hematol Source Type: research

Measurable residual disease after the first consolidation predicts the outcomes of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy.
Abstract We stratified patients with newly diagnosed acute promyelocytic leukemia (APL) according to a white blood cell (WBC) count of ≥ 3 × 109/L (high risk) or 
Source: International Journal of Hematology - June 10, 2020 Category: Hematology Authors: Henzan H, Takase K, Kamimura T, Mori Y, Yoshimoto G, Iwasaki H, Nagafuji K, Ogawa R, Eto T, Uchida N, Fujisaki T, Kato K, Minami M, Kikushige Y, Akashi K, Miyamoto T, Fukuoka Blood & Marrow Transplantation Group (FBMTG) Tags: Int J Hematol Source Type: research

Correlative analysis of overall survival with clinical characteristics in 127 patients with mantle cell lymphoma: a multi-institutional cohort in Taiwan.
Abstract Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma often with extranodal involvement at diagnosis, and yet how this feature correlates with survival awaits elucidation. To address this issue, a correlative analysis between clinical features of 127 MCL patients and their overall survival (OS) was conducted. In this cohort, the median age at MCL diagnosis was 62 years and 81% were males. Eighty-four percent of patients were Ann Arbor stage 4, and 15% were blastoid variants. In patients with gastrointestinal MCL, approximately 40% had gastric involvement. In treatment, CHOP-based induction chem...
Source: International Journal of Hematology - June 9, 2020 Category: Hematology Authors: Wang YH, Yu SC, Ko BS, Yang YT, Yao M, Tang JL, Huang TC Tags: Int J Hematol Source Type: research

Effect of age and comorbidities on the decline of glomerular filtration rate in chronic myeloid leukemia patients discontinuing tyrosine kinase inhibitors.
PMID: 32519172 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 9, 2020 Category: Hematology Authors: Lucijanic M, Krecak I Tags: Int J Hematol Source Type: research

Myelodysplastic syndromes in a pediatric patient with Cri du Chat syndrome with a ring chromosome 5.
Abstract Few hematological complications have previously been reported in association with Cri du Chat syndrome (CdCS). A case of myelodysplastic syndromes (MDS) in a pediatric patient with CdCS is herein presented. A 17-year-old female with CdCS caused by ring chromosome 5 was admitted to the hospital for investigation of a 1-month history of anemia. Based on the morphological findings of bone marrow, the patient was diagnosed with refractory cytopenia with multilineage dysplasia. The risk group was classified as intermediate-1 in the International Prognostic Scoring System (IPSS), and low in the revised IPSS. As...
Source: International Journal of Hematology - June 9, 2020 Category: Hematology Authors: Nozawa A, Ozeki M, Yasue S, Endo S, Kadowaki T, Ohnishi H, Muramatsu H, Hama A, Takahashi Y, Kojima S, Fukao T Tags: Int J Hematol Source Type: research

Extranasal extranodal NK/T-cell lymphoma associated with systemic lupus erythematosus.
We present the case of a 68-year-old-woman, who had been diagnosed with systemic lupus erythematosus (SLE) 28 years back and was treated with various immunosuppressive agents including steroids, cyclophosphamide, and tacrolimus. She presented with a progressively worsening swelling of the right thigh for the last few months. Radiological examination revealed an intramuscular bulky tumor without any other lesions and the biopsy results led to a diagnosis of extranodal NK/T-cell lymphoma, nasal type (ENKL). Concurrent chemoradiotherapy resulted in a complete response, which has been sustained for more than 2 years ...
Source: International Journal of Hematology - June 8, 2020 Category: Hematology Authors: Ichikawa S, Fukuhara N, Shirai T, Ishii T, Ichinohasama R, Harigae H Tags: Int J Hematol Source Type: research

Chronic kidney disease could be a risk factor for thrombosis in essential thrombocythemia and polycythemia vera.
Abstract Chronic kidney disease (CKD) is a well-known risk factor for venous thromboembolism and cardiovascular (CV) disease development in the general population, but its role in thrombotic risk in essential thrombocythemia (ET) and polycythemia vera (PV) remains poorly understood. This retrospective multicenter study analyzed clinical correlations and the potential impact of CKD on thrombosis development in ET and PV patients. We included 167 patients (76 ET and 91 PV); 25.7% had CKD at diagnosis, defined as estimated glomerular filtration rate (eGFR) 
Source: International Journal of Hematology - June 8, 2020 Category: Hematology Authors: Krečak I, Holik H, Martina MP, Zekanović I, Coha B, Gverić-Krečak V Tags: Int J Hematol Source Type: research

Clinical features and outcomes of adult Langerhans cell histiocytosis: a single-center experience.
Abstract Langerhans cell histiocytosis (LCH) is a clonally expanding neoplasm characterized by the accumulation of CD1a + CD207 + myeloid dendritic cells. As LCH is a rare disease and is presumed to mainly affect children, the clinical features and treatment outcomes of adult LCH have been poorly documented. We retrospectively reviewed 53 adult patients with LCH who were referred to the Institute of Medical Science, the University of Tokyo from 2005 to 2018. The median age at diagnosis was 42 years with a slight female predominance (57%). The time between onset and diagnosis varied...
Source: International Journal of Hematology - June 8, 2020 Category: Hematology Authors: Kobayashi M, Ando S, Kawamata T, Makiyama J, Yokoyama K, Imai Y, Tojo A Tags: Int J Hematol Source Type: research

Testicular plasmacytoma in a patient with relapsed multiple myeloma.
PMID: 32514930 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 8, 2020 Category: Hematology Authors: Pilalas D, Savopoulos C, Vakalopoulos I, Miliaras D, Lefkopoulos A, Kaiafa GD Tags: Int J Hematol Source Type: research

Diffuse alveolar hemorrhage during induction therapy for acute myeloid leukemia with inv(16)(p13.1q22).
PMID: 32506319 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 6, 2020 Category: Hematology Authors: Kanaya M, Kondo T Tags: Int J Hematol Source Type: research

Diffuse follicular lymphoma variant with a typical diagnostic pattern and an unusually aggressive clinical presentation.
We describe the case of an 80-year-old female diagnosed with diffuse FL variant, presented with a classic diagnostic pattern and an unusual aggressive clinical onset. PMID: 32506320 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 6, 2020 Category: Hematology Authors: Martín-Moro F, Marquet-Palomanes J, Piris-Villaespesa M, Lopez-Jiménez J, García-Cosío M Tags: Int J Hematol Source Type: research

The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse.
Abstract We evaluated the impact of FLT3-ITD, NPM1 mutations, and double mutant CEBPa (dmCEBPa) on overall survival (OS) after relapse in patients with cytogenetically intermediate-risk acute myeloid leukemia (AML) who were treated with chemotherapy alone in the first remission (CR1). Patients aged 16-65 years diagnosed with cytogenetically intermediate-risk AML, and who achieved CR1 were included. We retrospectively analyzed FLT3-ITD, NPM1 mutations and CEBPa using samples obtained at diagnosis, which therefore did not affect the therapeutic decisions. Among 235 patients who had achieved CR1, 152 relapsed, a...
Source: International Journal of Hematology - June 3, 2020 Category: Hematology Authors: Kurosawa S, Yamaguchi H, Yamaguchi T, Fukunaga K, Yui S, Kanamori H, Usuki K, Uoshima N, Yanada M, Takeuchi J, Mizuno I, Kanda J, Okamura H, Yano S, Tashiro H, Shindo T, Chiba S, Tomiyama J, Inokuchi K, Fukuda T Tags: Int J Hematol Source Type: research

Treatment-free remission after thrombopoietin receptor agonist discontinuation in patients with newly diagnosed immune thrombocytopenia: an observational retrospective analysis in real-world clinical practice.
In conclusion, patients with newly diagnosed ITP who achieve sustained response should consider discontinuation of TPO-RAs. PMID: 32476083 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 31, 2020 Category: Hematology Authors: Iino M, Sakamoto Y, Sato T Tags: Int J Hematol Source Type: research

Secondary hemophagocytic lymphohistiocytosis, HScore and COVID-19.
PMID: 32474804 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 30, 2020 Category: Hematology Authors: Loscocco GG Tags: Int J Hematol Source Type: research

T-cell posttransplant lymphoproliferative disorders after allogeneic hematopoietic cell transplantation.
Abstract Posttransplant lymphoproliferative disorder (PTLD) after allogeneic hematopoietic cell transplantation (HCT) is usually donor derived, associated with Epstein-Barr virus (EBV), and of B-cell origin. T-cell PTLD (T-PTLD) after allogeneic HCT is extremely rare. Four of 1015 (0.39%) allogeneic HCT patients were diagnosed with T-PTLD; peripheral T-cell lymphoma-not otherwise specified, anaplastic large cell lymphoma, monomorphic T-cell PTLD and polymorphic PTLD with chronic active EBV infection-like symptoms. Three of the four patients developed T-PTLD within 6 months after HCT from HLA-mismatched unrela...
Source: International Journal of Hematology - May 29, 2020 Category: Hematology Authors: Kuno M, Ito A, Maeshima AM, Taniguchi H, Tanaka T, Inamoto Y, Kurosawa S, Kim SW, Fukuda T Tags: Int J Hematol Source Type: research

Reply to the letter by Gaetano Loscocco, Secondary hemophagocytic lymphohistiocytosis, HScore and COVID-19.
PMID: 32468178 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 28, 2020 Category: Hematology Authors: Takami A Tags: Int J Hematol Source Type: research

Busulfan clearance does not predict the development of hepatic veno-occlusive disease in patients undergoing hematopoietic stem cell transplantation.
Abstract Hepatic veno-occlusive disease (VOD) is a life-threatening complication following hematopoietic stem cell transplant (HSCT). Busulfan has a narrow therapeutic index and its concentration was found to correlate with VOD. Our primary objective was to assess the association between busulfan clearance and VOD in HSCT patients. In this retrospective analysis, we included patients who received their HSCT between 2003 and 2014 and followed at Sultan Qaboos University Hospital. All patients who received dose-targeted busulfan-containing conditioning were included. Target steady-state concentration (Css) was ...
Source: International Journal of Hematology - May 28, 2020 Category: Hematology Authors: Salman B, Al-Khabori M, Al-Huneini M, Al-Rawas A, Dennison D, Al-Za'abi M Tags: Int J Hematol Source Type: research

Computed tomography-defined sarcopenia: prognostic predictor of nonrelapse mortality after allogeneic hematopoietic stem cell transplantation: a multicenter retrospective study.
Abstract We analyzed clinical cutoffs for defining computed tomography (CT) methods for sarcopenia and examined the prognostic value of CT for allogeneic hematopoietic stem cell transplantation (allo-HCST) outcomes of patients with myeloid malignancy. One hundred twenty-five adult patients with acute myeloid leukemia and myelodysplastic syndrome who underwent first allo-HSCT between 2000 and 2017 were included. Sarcopenia was assessed using CT-based skeletal muscle index (SMI) and mean muscle attenuation at L3. A statistical difference in SMI was confirmed between sarcopenia (n = 52) and nonsarcopeni...
Source: International Journal of Hematology - May 25, 2020 Category: Hematology Authors: Ando T, Fujisawa S, Teshigawara H, Matsumura A, Sakuma T, Suzuki T, Teranaka H, Ogusa E, Ishii Y, Miyashita K, Takahashi H, Nakajima Y, Miyazaki T, Hagihara M, Matsumoto K, Yamazaki E, Nakajima H Tags: Int J Hematol Source Type: research

Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study.
Abstract Autologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age ≥ 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age ≥ 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to AS...
Source: International Journal of Hematology - May 25, 2020 Category: Hematology Authors: Jung J, Choi YS, Lee JH, Lee WS, Kim SH, Park Y, Lee SS, Do YR, Jo JC, Lee JJ, Kim JS, Shin HJ, Shin DY, Yoon SS, Min CK, Kim K, Eom HS, Korean Multiple Myeloma Working Party (KMMWP) Tags: Int J Hematol Source Type: research

Possible role of low-dose etoposide therapy for hemophagocytic lymphohistiocytosis by COVID-19.
PMID: 32399895 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 12, 2020 Category: Hematology Authors: Takami A Tags: Int J Hematol Source Type: research

Real-world, retrospective study evaluating thromboembolic events, associated risk factors, and health-care resource utilization in Japanese patients with polycythemia vera.
Abstract In this retrospective, real-world study, we used medical claims data to evaluate the incidence of thromboembolic events (TEs), time to TE, associated risk factors, and health-care resource utilization (HRU) in Japanese patients with polycythemia vera (PV; N = 606) from April 1, 2008, to August 31, 2015. Baseline characteristics of interest included median age, 67.0 years; previous TEs, 11.6%; cardiovascular conditions (CVCs), 45.7%; and ≥ 3 risk factors, 17.8%. Overall, 100 patients experienced TEs (118 events) at a rate of 8.15/100 person-years [TE-free survival rate, ...
Source: International Journal of Hematology - May 11, 2020 Category: Hematology Authors: Komatsu N, Jun G, Yonezu T, Ohashi Y Tags: Int J Hematol Source Type: research

Functional characterization of a germline ETV6 variant associated with inherited thrombocytopenia, acute lymphoblastic leukemia, and salivary gland carcinoma in childhood.
We present a patient with short stature who was initially diagnosed with chronic immune thrombocytopenia. Subsequently, the patient developed acute lymphoblastic leukemia, followed by mammary analog secretory carcinoma. Sequencing analysis identified an ETV6 c.641C > T (p.Pro214Leu) germline variant. The variant protein exhibited attenuated nuclear localization, increased protein degradation, and reduced transcription repression function. Our findings suggest that the ETV6 gene should be sequenced in patients with inherited thrombocytopenia and malignancy, and emphasize the importance of careful follow-up ...
Source: International Journal of Hematology - May 4, 2020 Category: Hematology Authors: Yoshino H, Nishiyama Y, Kamma H, Chiba T, Fujiwara M, Karaho T, Kogashiwa Y, Morio T, Yan K, Bessho F, Takagi M Tags: Int J Hematol Source Type: research

JSH practical guidelines for hematological malignancies, 2018: I. Leukemia-2. Acute promyelocytic leukemia (APL).
PMID: 32347422 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - April 28, 2020 Category: Hematology Authors: Fujita H, Ishikawa Y, Yokoyama Y Tags: Int J Hematol Source Type: research

Persistent hypogammaglobulinemia due to immunoglobulin class switch impairment by peri-transplant rituximab therapy.
Abstract Post-transplant lymphoproliferative disorder (PTLD) is one of the most serious complications of allogeneic hematopoietic stem cell transplantation (HSCT). Rituximab is effective for PTLD; however, rituximab can produce adverse effects, including hypogammaglobulinemia. Here, we present the case of an 18-year-old female with refractory cytopenia of childhood who developed persistent selective hypogammaglobulinemia with low immunoglobulin G (IgG) 2 and IgG4 levels and monoclonal protein after rituximab therapy against probable PTLD. Despite B-cell recovery, the serum IgG levels gradually declined, reaching 
Source: International Journal of Hematology - April 27, 2020 Category: Hematology Authors: Mizuhara K, Fujii N, Meguri Y, Takahashi T, Aoe M, Nakamura M, Seike K, Sando Y, Fujii K, Abe M, Sumii Y, Urata T, Fujiwara Y, Saeki K, Asada N, Ennishi D, Nishimori H, Matsuoka KI, Maeda Y Tags: Int J Hematol Source Type: research

Characterization of hereditary factor XI deficiency in Taiwanese patients: identification of three novel and two common mutations.
Abstract Hereditary coagulation factor XI (FXI) deficiency is a rare bleeding disorder, but information on FXI deficiency in Taiwanese patients remains scarce. We evaluated clinical and genetic features of severe FXI deficiency patients in Taiwan. We collected clinical information and performed coagulation laboratory tests and genetic studies in ten unrelated Taiwanese families with severe FXI deficiency. FXI coagulation activity was assayed using a one-stage method. FXI antigen was determined using enzyme-linked immunosorbent assay. Underlying genetic mutations were evaluated using direct sequencing methods. Ten ...
Source: International Journal of Hematology - April 24, 2020 Category: Hematology Authors: Lin HY, Lin CY, Hung MH, Kuo SF, Lin JS, Shen MC Tags: Int J Hematol Source Type: research