Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen
CONCLUSION: Patients with less well-matched grafts have a higher incidence of LOHC. Inherent deficiencies in immunity in the context of HLA disparity and more intense pharmacologic immunosuppression after severe acute graft-versus-host disease may contribute to viral activation. Prevention and treatment of LOHC have the potential to prolong long-term survival.PMID:34117990 | DOI:10.1007/s12185-021-03168-w (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Huimin Jiang Liangquan Geng Xiang Wan Kaidi Song Juan Tong Xiaoyu Zhu Baolin Tang Wen Yao Xuhan Zhang Guangyu Sun Lei Zhang Zimin Sun Huilan Liu Source Type: research

Novel variant fibrinogen γp.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment
CONCLUSION: We demonstrated that fibrinogen N-II, γp.C352R was associated with markedly reduced secretion of variant fibrinogen from CHO cells, that fibrin polymerization of purified plasma fibrinogen was only slightly affected, and that fibrinogen N-II produces hypodysfibrinogenemia in plasma.PMID:34117991 | DOI:10.1007/s12185-021-03174-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Masahiro Yoda Takahiro Kaido Tomu Kamijo Chiaki Taira Yumiko Higuchi Shinpei Arai Nobuo Okumura Source Type: research

Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen
CONCLUSION: Patients with less well-matched grafts have a higher incidence of LOHC. Inherent deficiencies in immunity in the context of HLA disparity and more intense pharmacologic immunosuppression after severe acute graft-versus-host disease may contribute to viral activation. Prevention and treatment of LOHC have the potential to prolong long-term survival.PMID:34117990 | DOI:10.1007/s12185-021-03168-w (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Huimin Jiang Liangquan Geng Xiang Wan Kaidi Song Juan Tong Xiaoyu Zhu Baolin Tang Wen Yao Xuhan Zhang Guangyu Sun Lei Zhang Zimin Sun Huilan Liu Source Type: research

Novel variant fibrinogen γp.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment
CONCLUSION: We demonstrated that fibrinogen N-II, γp.C352R was associated with markedly reduced secretion of variant fibrinogen from CHO cells, that fibrin polymerization of purified plasma fibrinogen was only slightly affected, and that fibrinogen N-II produces hypodysfibrinogenemia in plasma.PMID:34117991 | DOI:10.1007/s12185-021-03174-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Masahiro Yoda Takahiro Kaido Tomu Kamijo Chiaki Taira Yumiko Higuchi Shinpei Arai Nobuo Okumura Source Type: research

Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen
CONCLUSION: Patients with less well-matched grafts have a higher incidence of LOHC. Inherent deficiencies in immunity in the context of HLA disparity and more intense pharmacologic immunosuppression after severe acute graft-versus-host disease may contribute to viral activation. Prevention and treatment of LOHC have the potential to prolong long-term survival.PMID:34117990 | DOI:10.1007/s12185-021-03168-w (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Huimin Jiang Liangquan Geng Xiang Wan Kaidi Song Juan Tong Xiaoyu Zhu Baolin Tang Wen Yao Xuhan Zhang Guangyu Sun Lei Zhang Zimin Sun Huilan Liu Source Type: research

Novel variant fibrinogen γp.C352R produced hypodysfibrinogenemia leading to a bleeding episode and failure of infertility treatment
CONCLUSION: We demonstrated that fibrinogen N-II, γp.C352R was associated with markedly reduced secretion of variant fibrinogen from CHO cells, that fibrin polymerization of purified plasma fibrinogen was only slightly affected, and that fibrinogen N-II produces hypodysfibrinogenemia in plasma.PMID:34117991 | DOI:10.1007/s12185-021-03174-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 12, 2021 Category: Hematology Authors: Masahiro Yoda Takahiro Kaido Tomu Kamijo Chiaki Taira Yumiko Higuchi Shinpei Arai Nobuo Okumura Source Type: research

Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation
We present the case of a child with severe HAA who underwent LDLT, and who achieved rapid blood cell recovery with IST combined with romiplostim, a thrombopoietin receptor agonist. In addition, despite having undergone LDLT, the patient had no adverse events such as serious liver dysfunction or thrombosis. This case suggests that IST combined with thrombopoietin receptor agonists may be a promising treatment option for HAA patients undergoing LDLT.PMID:34110619 | DOI:10.1007/s12185-021-03165-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 10, 2021 Category: Hematology Authors: Hiroki Yoshinari Yuta Kawahara Hitomi Niijima Yukiko Oh Yuta Hirata Noriki Okada Yukihiro Sanada Yasuharu Onishi Yasunaru Sakuma Akira Morimoto Source Type: research

Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation
We present the case of a child with severe HAA who underwent LDLT, and who achieved rapid blood cell recovery with IST combined with romiplostim, a thrombopoietin receptor agonist. In addition, despite having undergone LDLT, the patient had no adverse events such as serious liver dysfunction or thrombosis. This case suggests that IST combined with thrombopoietin receptor agonists may be a promising treatment option for HAA patients undergoing LDLT.PMID:34110619 | DOI:10.1007/s12185-021-03165-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 10, 2021 Category: Hematology Authors: Hiroki Yoshinari Yuta Kawahara Hitomi Niijima Yukiko Oh Yuta Hirata Noriki Okada Yukihiro Sanada Yasuharu Onishi Yasunaru Sakuma Akira Morimoto Source Type: research

Rapid blood cell recovery with immunosuppressive therapy combined with romiplostim in a patient with very severe hepatitis-associated aplastic anemia who underwent liver transplantation
We present the case of a child with severe HAA who underwent LDLT, and who achieved rapid blood cell recovery with IST combined with romiplostim, a thrombopoietin receptor agonist. In addition, despite having undergone LDLT, the patient had no adverse events such as serious liver dysfunction or thrombosis. This case suggests that IST combined with thrombopoietin receptor agonists may be a promising treatment option for HAA patients undergoing LDLT.PMID:34110619 | DOI:10.1007/s12185-021-03165-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 10, 2021 Category: Hematology Authors: Hiroki Yoshinari Yuta Kawahara Hitomi Niijima Yukiko Oh Yuta Hirata Noriki Okada Yukihiro Sanada Yasuharu Onishi Yasunaru Sakuma Akira Morimoto Source Type: research

Clinical outcomes of interferon therapy for polycythemia vera and essential thrombocythemia: a systematic review and meta-analysis
Int J Hematol. 2021 Jun 6. doi: 10.1007/s12185-021-03171-1. Online ahead of print.ABSTRACTInterferon therapy has been used in clinical practice for more than three decades to treat polycythemia vera (PV) and essential thrombocythemia (ET). However, there has been no systematic investigation of its expected outcomes and potential risks. We performed a systematic review and single-arm meta-analysis to assess the clinical outcomes (hematological response, molecular response, vascular events, hematological transformation, and adverse events) after interferon therapy for patients with PV and ET. A systematic search identified 3...
Source: International Journal of Hematology - June 6, 2021 Category: Hematology Authors: Wenjing Gu Renchi Yang Zhijian Xiao Lei Zhang Source Type: research

Incidence of venous thromboembolism in patients with solid cancers in Japan: retrospective study of 2735 patients
CONCLUSIONS: In this retrospective study, the incidence of CA-VTE in Japanese patients with cancer was equivalent to that in Western populations. Approximately half of CA-VTE patients were asymptomatic and 6% had normal D-dimer levels, indicating the need for closer attention to occult CA-VTE.PMID:34091877 | DOI:10.1007/s12185-021-03167-x (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 6, 2021 Category: Hematology Authors: Taku Nose Yoshinori Imamura Shinya Ohata Shiro Kimbara Yoshiharu Miyata Yasuko Hyogo Yoshimi Fujishima Yohei Funakoshi Masanori Toyoda Naomi Kiyota Hironobu Minami Source Type: research

Clinical outcomes of interferon therapy for polycythemia vera and essential thrombocythemia: a systematic review and meta-analysis
Int J Hematol. 2021 Jun 6. doi: 10.1007/s12185-021-03171-1. Online ahead of print.ABSTRACTInterferon therapy has been used in clinical practice for more than three decades to treat polycythemia vera (PV) and essential thrombocythemia (ET). However, there has been no systematic investigation of its expected outcomes and potential risks. We performed a systematic review and single-arm meta-analysis to assess the clinical outcomes (hematological response, molecular response, vascular events, hematological transformation, and adverse events) after interferon therapy for patients with PV and ET. A systematic search identified 3...
Source: International Journal of Hematology - June 6, 2021 Category: Hematology Authors: Wenjing Gu Renchi Yang Zhijian Xiao Lei Zhang Source Type: research

Incidence of venous thromboembolism in patients with solid cancers in Japan: retrospective study of 2735 patients
CONCLUSIONS: In this retrospective study, the incidence of CA-VTE in Japanese patients with cancer was equivalent to that in Western populations. Approximately half of CA-VTE patients were asymptomatic and 6% had normal D-dimer levels, indicating the need for closer attention to occult CA-VTE.PMID:34091877 | DOI:10.1007/s12185-021-03167-x (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 6, 2021 Category: Hematology Authors: Taku Nose Yoshinori Imamura Shinya Ohata Shiro Kimbara Yoshiharu Miyata Yasuko Hyogo Yoshimi Fujishima Yohei Funakoshi Masanori Toyoda Naomi Kiyota Hironobu Minami Source Type: research

Clinical outcomes of interferon therapy for polycythemia vera and essential thrombocythemia: a systematic review and meta-analysis
Int J Hematol. 2021 Jun 6. doi: 10.1007/s12185-021-03171-1. Online ahead of print.ABSTRACTInterferon therapy has been used in clinical practice for more than three decades to treat polycythemia vera (PV) and essential thrombocythemia (ET). However, there has been no systematic investigation of its expected outcomes and potential risks. We performed a systematic review and single-arm meta-analysis to assess the clinical outcomes (hematological response, molecular response, vascular events, hematological transformation, and adverse events) after interferon therapy for patients with PV and ET. A systematic search identified 3...
Source: International Journal of Hematology - June 6, 2021 Category: Hematology Authors: Wenjing Gu Renchi Yang Zhijian Xiao Lei Zhang Source Type: research

Incidence of venous thromboembolism in patients with solid cancers in Japan: retrospective study of 2735 patients
CONCLUSIONS: In this retrospective study, the incidence of CA-VTE in Japanese patients with cancer was equivalent to that in Western populations. Approximately half of CA-VTE patients were asymptomatic and 6% had normal D-dimer levels, indicating the need for closer attention to occult CA-VTE.PMID:34091877 | DOI:10.1007/s12185-021-03167-x (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 6, 2021 Category: Hematology Authors: Taku Nose Yoshinori Imamura Shinya Ohata Shiro Kimbara Yoshiharu Miyata Yasuko Hyogo Yoshimi Fujishima Yohei Funakoshi Masanori Toyoda Naomi Kiyota Hironobu Minami Source Type: research

Prognostic impact of the dosage of methotrexate combined with tacrolimus for graft-versus-host disease prophylaxis after cord blood transplantation
Int J Hematol. 2021 Jun 4. doi: 10.1007/s12185-021-03161-3. Online ahead of print.ABSTRACTThe optimal dosage of methotrexate (MTX) for graft-versus-host disease (GVHD) prophylaxis after cord blood transplantation (CBT) has not been well elucidated. Therefore, we conducted a retrospective study comparing a mini-MTX group (5 mg/m2 on day 1, 3 and 6) to a short-MTX group (10 mg/m2 on day 1 and 7 mg/m2 on day 3 and 6) after CBT. Sixty-three patients were classified as the mini-MTX group and 20 as the short-MTX group. The median time and cumulative incidence of neutrophil engraftment did not vary between the two groups. The cum...
Source: International Journal of Hematology - June 4, 2021 Category: Hematology Authors: Miwa Adachi Daisuke Yokota Hiroya Hirata Katsumi Koyauchi Satoshi Dohtan Shinichiro Oka Nami Sakamoto Masamitsu Takaba Tomonari Takemura Yasuyuki Nagata Kensuke Naito Takaaki Ono Source Type: research

Prognostic impact of the dosage of methotrexate combined with tacrolimus for graft-versus-host disease prophylaxis after cord blood transplantation
Int J Hematol. 2021 Jun 4. doi: 10.1007/s12185-021-03161-3. Online ahead of print.ABSTRACTThe optimal dosage of methotrexate (MTX) for graft-versus-host disease (GVHD) prophylaxis after cord blood transplantation (CBT) has not been well elucidated. Therefore, we conducted a retrospective study comparing a mini-MTX group (5 mg/m2 on day 1, 3 and 6) to a short-MTX group (10 mg/m2 on day 1 and 7 mg/m2 on day 3 and 6) after CBT. Sixty-three patients were classified as the mini-MTX group and 20 as the short-MTX group. The median time and cumulative incidence of neutrophil engraftment did not vary between the two groups. The cum...
Source: International Journal of Hematology - June 4, 2021 Category: Hematology Authors: Miwa Adachi Daisuke Yokota Hiroya Hirata Katsumi Koyauchi Satoshi Dohtan Shinichiro Oka Nami Sakamoto Masamitsu Takaba Tomonari Takemura Yasuyuki Nagata Kensuke Naito Takaaki Ono Source Type: research

Prognostic impact of the dosage of methotrexate combined with tacrolimus for graft-versus-host disease prophylaxis after cord blood transplantation
Int J Hematol. 2021 Jun 4. doi: 10.1007/s12185-021-03161-3. Online ahead of print.ABSTRACTThe optimal dosage of methotrexate (MTX) for graft-versus-host disease (GVHD) prophylaxis after cord blood transplantation (CBT) has not been well elucidated. Therefore, we conducted a retrospective study comparing a mini-MTX group (5 mg/m2 on day 1, 3 and 6) to a short-MTX group (10 mg/m2 on day 1 and 7 mg/m2 on day 3 and 6) after CBT. Sixty-three patients were classified as the mini-MTX group and 20 as the short-MTX group. The median time and cumulative incidence of neutrophil engraftment did not vary between the two groups. The cum...
Source: International Journal of Hematology - June 4, 2021 Category: Hematology Authors: Miwa Adachi Daisuke Yokota Hiroya Hirata Katsumi Koyauchi Satoshi Dohtan Shinichiro Oka Nami Sakamoto Masamitsu Takaba Tomonari Takemura Yasuyuki Nagata Kensuke Naito Takaaki Ono Source Type: research

Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan
This study emphasizes the need to consider sex and age in the clinical use of reference intervals of RBC parameters.PMID:34080169 | DOI:10.1007/s12185-021-03166-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 3, 2021 Category: Hematology Authors: Akiyoshi Takami Shinichiro Watanabe Yoshikazu Yamamoto Hiroshi Kondo Yukiharu Bamba Masahiko Ohata Seiji Mishima Hiroshi Kubota Akihiko Nishiura Reiko Miura Miyuki Iwagami Katsumi Higashi Yutaka Yatomi Kaoru Tohyama Japanese Society for Laboratory Hematol Source Type: research

Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan
This study emphasizes the need to consider sex and age in the clinical use of reference intervals of RBC parameters.PMID:34080169 | DOI:10.1007/s12185-021-03166-y (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 3, 2021 Category: Hematology Authors: Akiyoshi Takami Shinichiro Watanabe Yoshikazu Yamamoto Hiroshi Kondo Yukiharu Bamba Masahiko Ohata Seiji Mishima Hiroshi Kubota Akihiko Nishiura Reiko Miura Miyuki Iwagami Katsumi Higashi Yutaka Yatomi Kaoru Tohyama Japanese Society for Laboratory Hematol Source Type: research

Sarcoma-like appearance but pathologic Hodgkin lymphoma
Int J Hematol. 2021 May 31. doi: 10.1007/s12185-021-03169-9. Online ahead of print.NO ABSTRACTPMID:34059996 | DOI:10.1007/s12185-021-03169-9 (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 1, 2021 Category: Hematology Authors: Sakiko Harada Jun Ando Miki Ando Yoko Azusawa Tomonori Ochiai Yoshinori Hashimoto Yusuke Hirasawa Norio Komatsu Source Type: research

Correction to: Patient's age and D ‑dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Jun 1. doi: 10.1007/s12185-021-03170-2. Online ahead of print.NO ABSTRACTPMID:34061294 | DOI:10.1007/s12185-021-03170-2 (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 1, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Sarcoma-like appearance but pathologic Hodgkin lymphoma
Int J Hematol. 2021 May 31. doi: 10.1007/s12185-021-03169-9. Online ahead of print.NO ABSTRACTPMID:34059996 | DOI:10.1007/s12185-021-03169-9 (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 1, 2021 Category: Hematology Authors: Sakiko Harada Jun Ando Miki Ando Yoko Azusawa Tomonori Ochiai Yoshinori Hashimoto Yusuke Hirasawa Norio Komatsu Source Type: research

Correction to: Patient's age and D ‑dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Jun 1. doi: 10.1007/s12185-021-03170-2. Online ahead of print.NO ABSTRACTPMID:34061294 | DOI:10.1007/s12185-021-03170-2 (Source: International Journal of Hematology)
Source: International Journal of Hematology - June 1, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Acquired hypofibrinogenemia in a patient with multiple myeloma
We report a case of acquired hypofibrinogenemia with multiple myeloma presenting λ-type IgG monoclonal protein. The patient had anemia and renal deficiency, and also developed bleeding tendency due to severe coagulopathy. Her fibrinogen level was under the detectable limits in a functional assay. Enzyme-linked immunosorbent assay (ELISA) and immunoblotting analysis results were consistent with functional assay results, and deficiency patterns observed in cross-mixing tests for PT and aPTT confirmed the diagnosis of hypofibrinogenemia. To determine the cause of hypofibrinogenemia, we purified the patient's immunoglob...
Source: International Journal of Hematology - May 31, 2021 Category: Hematology Authors: Shojiro Inano Yuki Oku Akiko Aiba Naoto Kawasaki Yoshio Okamoto Naoki Yuhi Sho Shibata Yoko Takiuchi Sumie Tabata Toshiyuki Kitano Source Type: research

Acquired hypofibrinogenemia in a patient with multiple myeloma
We report a case of acquired hypofibrinogenemia with multiple myeloma presenting λ-type IgG monoclonal protein. The patient had anemia and renal deficiency, and also developed bleeding tendency due to severe coagulopathy. Her fibrinogen level was under the detectable limits in a functional assay. Enzyme-linked immunosorbent assay (ELISA) and immunoblotting analysis results were consistent with functional assay results, and deficiency patterns observed in cross-mixing tests for PT and aPTT confirmed the diagnosis of hypofibrinogenemia. To determine the cause of hypofibrinogenemia, we purified the patient's immunoglob...
Source: International Journal of Hematology - May 31, 2021 Category: Hematology Authors: Shojiro Inano Yuki Oku Akiko Aiba Naoto Kawasaki Yoshio Okamoto Naoki Yuhi Sho Shibata Yoko Takiuchi Sumie Tabata Toshiyuki Kitano Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Evaluation of beta-2 microglobulin, erythropoietin and tobacco use in polycythemic cases
Int J Hematol. 2021 May 22. doi: 10.1007/s12185-021-03164-0. Online ahead of print.ABSTRACTIn the 2016 WHO classification, hemoglobin and hematocrit thresholds for diagnosing polycythemia vera (PV) have been lowered, increasing the number of consultations for polycythemia investigations. In PV, beta-2 microglobulin (B2m) levels are reportedly increased, whereas erythropoietin (EPO) levels are usually low. Most secondary polycythemia cases (SP) are caused by tobacco use. We decided to analyze the relevance of these three parameters in all patients seen for polycythemia investigations to help differentiate PV from SP cases. ...
Source: International Journal of Hematology - May 22, 2021 Category: Hematology Authors: Kristell Mahe Francis Couturaud H élène Kerspern Aur élie Chauveau Jean-Christophe Ianotto Source Type: research

Asian population may have a lower incidence of hip osteonecrosis in childhood acute lymphoblastic leukemia
Int J Hematol. 2021 May 18. doi: 10.1007/s12185-021-03163-1. Online ahead of print.ABSTRACTOsteonecrosis (ON), a long-term complication of acute lymphoblastic leukemia (ALL) treatment affects patients' quality of life. Although the incidence of any ON, including asymptomatic, was 21.7% among children with ALL in the U.S., the actual incidence and risk factors in Asia remain unknown. For over 11 years, we performed hip magnetic resonance imaging (MRI) screening to detect asymptomatic ON while initiating maintenance chemotherapy in newly diagnosed children with ALL. Overall, 164 of 175 patients underwent hip MRI screening. T...
Source: International Journal of Hematology - May 19, 2021 Category: Hematology Authors: Yuki Arakawa Satoshi Masutani Koichi Oshima Yuichi Mitani Makiko Mori Kohei Fukuoka Koichi Moriwaki Motohiro Kato Katsuaki Taira Yutaka Tanami Atsuko Nakazawa Katsuyoshi Koh Source Type: research

Bilateral anterior cerebral artery occlusion following CD19- and BCMA-targeted chimeric antigen receptor T-cell therapy for a myeloma patient
We reported a 73-year-old female MM patient who received CD19- and BCMA-targeted CAR-T for refractory disease. Her disease responded to CAR-T therapy, but she developed neurological symptoms following CRS. Cranial CT and MRI demonstrated multiple cerebral infarctions and bilateral anterior cerebral artery (ACA) occlusion. We suggest that cerebral infarction other than CAR-T-related neurotoxicity is the underlying cause of abnormal neuropsychological symptoms, and diagnostic imaging tests should be actively performed to exclude ischemic cerebrovascular events.PMID:34009622 | PMC:PMC8131494 | DOI:10.1007/s12185-021-03160-4 (...
Source: International Journal of Hematology - May 19, 2021 Category: Hematology Authors: Li-Xia Wang Xian-Qiu Yu Jiang Cao Yi-Long Lu Ming Luo Fang Lei Yu Tang Xiao-Ming Fei Source Type: research

Asian population may have a lower incidence of hip osteonecrosis in childhood acute lymphoblastic leukemia
Int J Hematol. 2021 May 18. doi: 10.1007/s12185-021-03163-1. Online ahead of print.ABSTRACTOsteonecrosis (ON), a long-term complication of acute lymphoblastic leukemia (ALL) treatment affects patients' quality of life. Although the incidence of any ON, including asymptomatic, was 21.7% among children with ALL in the U.S., the actual incidence and risk factors in Asia remain unknown. For over 11 years, we performed hip magnetic resonance imaging (MRI) screening to detect asymptomatic ON while initiating maintenance chemotherapy in newly diagnosed children with ALL. Overall, 164 of 175 patients underwent hip MRI screening. T...
Source: International Journal of Hematology - May 19, 2021 Category: Hematology Authors: Yuki Arakawa Satoshi Masutani Koichi Oshima Yuichi Mitani Makiko Mori Kohei Fukuoka Koichi Moriwaki Motohiro Kato Katsuaki Taira Yutaka Tanami Atsuko Nakazawa Katsuyoshi Koh Source Type: research

Bilateral anterior cerebral artery occlusion following CD19- and BCMA-targeted chimeric antigen receptor T-cell therapy for a myeloma patient
We reported a 73-year-old female MM patient who received CD19- and BCMA-targeted CAR-T for refractory disease. Her disease responded to CAR-T therapy, but she developed neurological symptoms following CRS. Cranial CT and MRI demonstrated multiple cerebral infarctions and bilateral anterior cerebral artery (ACA) occlusion. We suggest that cerebral infarction other than CAR-T-related neurotoxicity is the underlying cause of abnormal neuropsychological symptoms, and diagnostic imaging tests should be actively performed to exclude ischemic cerebrovascular events.PMID:34009622 | PMC:PMC8131494 | DOI:10.1007/s12185-021-03160-4 (...
Source: International Journal of Hematology - May 19, 2021 Category: Hematology Authors: Li-Xia Wang Xian-Qiu Yu Jiang Cao Yi-Long Lu Ming Luo Fang Lei Yu Tang Xiao-Ming Fei Source Type: research

Asian population may have a lower incidence of hip osteonecrosis in childhood acute lymphoblastic leukemia
Int J Hematol. 2021 May 18. doi: 10.1007/s12185-021-03163-1. Online ahead of print.ABSTRACTOsteonecrosis (ON), a long-term complication of acute lymphoblastic leukemia (ALL) treatment affects patients' quality of life. Although the incidence of any ON, including asymptomatic, was 21.7% among children with ALL in the U.S., the actual incidence and risk factors in Asia remain unknown. For over 11 years, we performed hip magnetic resonance imaging (MRI) screening to detect asymptomatic ON while initiating maintenance chemotherapy in newly diagnosed children with ALL. Overall, 164 of 175 patients underwent hip MRI screening. T...
Source: International Journal of Hematology - May 19, 2021 Category: Hematology Authors: Yuki Arakawa Satoshi Masutani Koichi Oshima Yuichi Mitani Makiko Mori Kohei Fukuoka Koichi Moriwaki Motohiro Kato Katsuaki Taira Yutaka Tanami Atsuko Nakazawa Katsuyoshi Koh Source Type: research

Bilateral anterior cerebral artery occlusion following CD19- and BCMA-targeted chimeric antigen receptor T-cell therapy for a myeloma patient
We reported a 73-year-old female MM patient who received CD19- and BCMA-targeted CAR-T for refractory disease. Her disease responded to CAR-T therapy, but she developed neurological symptoms following CRS. Cranial CT and MRI demonstrated multiple cerebral infarctions and bilateral anterior cerebral artery (ACA) occlusion. We suggest that cerebral infarction other than CAR-T-related neurotoxicity is the underlying cause of abnormal neuropsychological symptoms, and diagnostic imaging tests should be actively performed to exclude ischemic cerebrovascular events.PMID:34009622 | DOI:10.1007/s12185-021-03160-4 (Source: Internati...
Source: International Journal of Hematology - May 19, 2021 Category: Hematology Authors: Li-Xia Wang Xian-Qiu Yu Jiang Cao Yi-Long Lu Ming Luo Fang Lei Yu Tang Xiao-Ming Fei Source Type: research

Expression of activated integrin β7 in multiple myeloma patients
In this study, we performed flow cytometry analysis of the expression of activated integrin β7 in bone marrow cells from 137 symptomatic MM patients. In 60/137 (44%) MM patients, activated integrin β7 was detected in most MM cells (> 80% of MM cells were in the positive gate). Activated integrin β7 was highly expressed in MM cells even in heavily treated patients. It also showed high expression in many CD38lo/-CD138-CD19+B cells, which reportedly include clonotypic B cells, in the bone marrow of MM patients. Taken together, these results suggest that CAR T-cell therapy targeting activated integrin β7...
Source: International Journal of Hematology - May 17, 2021 Category: Hematology Authors: Naoki Hosen Satoshi Yoshihara Hiroyuki Takamatsu Masaki Ri Yasuyuki Nagata Hiroshi Kosugi Yoshimitsu Shimomura Ichiro Hanamura Shigeo Fuji Koichiro Minauchi Junya Kuroda Rikio Suzuki Noriko Nishimura Nobuhiko Uoshima Hirohisa Nakamae Yawara Kawano Ishikaz Source Type: research

Expression of activated integrin β7 in multiple myeloma patients
In this study, we performed flow cytometry analysis of the expression of activated integrin β7 in bone marrow cells from 137 symptomatic MM patients. In 60/137 (44%) MM patients, activated integrin β7 was detected in most MM cells (> 80% of MM cells were in the positive gate). Activated integrin β7 was highly expressed in MM cells even in heavily treated patients. It also showed high expression in many CD38lo/-CD138-CD19+B cells, which reportedly include clonotypic B cells, in the bone marrow of MM patients. Taken together, these results suggest that CAR T-cell therapy targeting activated integrin β7...
Source: International Journal of Hematology - May 17, 2021 Category: Hematology Authors: Naoki Hosen Satoshi Yoshihara Hiroyuki Takamatsu Masaki Ri Yasuyuki Nagata Hiroshi Kosugi Yoshimitsu Shimomura Ichiro Hanamura Shigeo Fuji Koichiro Minauchi Junya Kuroda Rikio Suzuki Noriko Nishimura Nobuhiko Uoshima Hirohisa Nakamae Yawara Kawano Ishikaz Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research

Patient's age and D-dimer levels predict the prognosis in patients with TAFRO syndrome
Int J Hematol. 2021 Apr 30:1-10. doi: 10.1007/s12185-021-03159-x. Online ahead of print.ABSTRACTTo identify prognostic factors for TAFRO syndrome, a rare inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. Data of patients with TAFRO syndrome were extracted from a Japanese patient registry. Patients were divided into groups according to the clinical and laboratory parameters at initial presentation. Cut-off values for the laboratory parameters were determined using receiver operating characteristic curve analysis and by ...
Source: International Journal of Hematology - April 30, 2021 Category: Hematology Authors: Hiroshi Kawabata Shino Fujimoto Tomoyuki Sakai Hiroto Yanagisawa Toshio Kitawaki Kenji Nara Masao Hagihara Hiroshi Yamamoto Masakuni Tanimizu Chikako Kato Tomoki Origuchi Kazutaka Sunami Yoshitaka Sunami Taro Masunari Nobuhiko Nakamura Masanori Kobayashi Source Type: research