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High-dose chemotherapy and autologous peripheral blood stem cell transplantation with BCVAC regimen followed by maintenance chemotherapy for children with very high risk acute lymphoblastic leukemia.
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the recommended treatment for children with very high risk acute lymphoblastic leukemia (ALL), but it requires adequate institutional infrastructure, experience, and expertise, especially for alternative donor HSCT. We review our experience with high-dose chemotherapy (HDCT) and autologous peripheral blood stem cell transplantation (APBSCT), followed by post-APBSCT maintenance chemotherapy for children with very high risk ALL. Between August 1997 and November 2012, our institute was not successful with HLA-haploidentical HSCT. Thus, if pati...
Source: International Journal of Hematology - October 20, 2017 Category: Hematology Authors: Hong CR, Kang HJ, Park KD, Shin HY, Ahn HS Tags: Int J Hematol Source Type: research

Collision of metastatic malignant melanoma and acute myelogenous leukemia in the bone marrow.
PMID: 29043550 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 17, 2017 Category: Hematology Authors: Kobayashi N, Shimizu H, Hirato J, Handa H Tags: Int J Hematol Source Type: research

MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.
In this study we found that MAGI-1 expression is decreased in multiple (9 out of 15) human T-cell leukemia cell lines, including adult T-cell leukemia (ATL), T-cell acute lymphoblastic leukemia and chronic T-cell lymphocytic leukemia. The overexpression of MAGI-1 protein in a MAGI-1-low ATL cell line reduced cellular growth. While the overexpression of MAGI-1 protein in a MAGI-1-low ATL cell line reduced the Akt and MEK activities, the knockdown of MAGI-1 in a MAGI-1-high ATL cell line augmented the Akt and MEK activities. Collectively, the findings of the present study suggest that the decreased expression of MAGI-1 in hu...
Source: International Journal of Hematology - October 17, 2017 Category: Hematology Authors: Kozakai T, Takahashi M, Higuchi M, Hara T, Saito K, Tanaka Y, Masuko M, Takizawa J, Sone H, Fujii M Tags: Int J Hematol Source Type: research

Sudden blast phase in chronic myeloid leukemia developed during nilotinib therapy after major molecular response was achieved.
Abstract Sudden blast phase (SBP) is a rare event in which patients with chronic myeloid leukemia (CML) in complete cytogenetic response (CCyR) rapidly progress to the blast phase. Few patients on second-generation tyrosine kinase inhibitors (2nd TKIs) have been reported to develop SBP. Here, we report a 45-year-old man diagnosed with CML in the chronic phase in April 2008 and immediately started on imatinib therapy. He achieved CCyR 12 months after starting imatinib therapy. Imatinib was followed by treatment with the 2nd TKIs nilotinib and dasatinib from January 2011 to yield a better response. He achieved ...
Source: International Journal of Hematology - October 14, 2017 Category: Hematology Authors: Okada Y, Sato K, Kobayashi S, Nagao S, Takano K, Teramoto M, Tachi N, Kawamura T, Horiuchi T, Kato S, Saga R, Maekawa T, Yamamura T, Watanabe J, Kobayashi A, Kimura F Tags: Int J Hematol Source Type: research

Prognostic impact of minimal disseminated disease and immune response to NPM-ALK in Japanese children with ALK-positive anaplastic large cell lymphoma.
Abstract The prognostic impact of minimal disseminated disease (MDD) and anti-anaplastic lymphoma kinase (ALK) antibody titer in children with ALK-positive anaplastic large cell lymphoma (ALCL) was reported by an Italian/German group. Here, we examine their prognostic value in Japanese children with ALK-positive ALCL. We evaluated nucleophosmin (NPM)-ALK transcripts in 60 patients at diagnosis by RT-PCR and real-time PCR (qPCR). The antibody titer was assessed in 35 patients. Fifty-two percent were MDD positive by RT-PCR and 37% had more than 10 copies of NPM-ALK per 10(4) copies of ABL (10NCNs) by qPCR. Fifty-one...
Source: International Journal of Hematology - October 13, 2017 Category: Hematology Authors: Iijima-Yamashita Y, Mori T, Nakazawa A, Fukano R, Takimoto T, Tsurusawa M, Kobayashi R, Horibe K Tags: Int J Hematol Source Type: research

Prospective observational study on the first 51 cases of peripheral blood stem cell transplantation from unrelated donors in Japan.
Abstract The Japan Marrow Donor Program (JMDP) has facilitated unrelated peripheral blood stem cell transplantation (URPBSCT) since 2010. We conducted a prospective multicenter observational study to evaluate the feasibility of such transplantation. Between 2011 and 2014, 51 patients underwent URPBSCT from 8/8 allele-matched donors for hematological malignancies. The median age of the patients was 50 years; 21 had high-risk disease. Myeloablative conditioning regimens were used in 31 patients, and tacrolimus based graft-versus-host disease (GVHD) prophylaxis was used for all patients. The cumulative rate of e...
Source: International Journal of Hematology - October 13, 2017 Category: Hematology Authors: Goto T, Tanaka T, Sawa M, Ueda Y, Ago H, Chiba S, Kanamori H, Nishikawa A, Nougawa M, Ohashi K, Okumura H, Tanimoto M, Fukuda T, Kawashima N, Kato T, Okada K, Nagafuji K, Okamoto SI, Atsuta Y, Hino M, Tanaka J, Miyamura K Tags: Int J Hematol Source Type: research

Plasma cell myeloma mimicking classical Hodgkin lymphoma in the bone marrow.
PMID: 29027630 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 13, 2017 Category: Hematology Authors: Karner KH, Inamdar KV Tags: Int J Hematol Source Type: research

Fluconazole versus mould-active triazoles for primary antifungal prophylaxis in adult patients with acute lymphoblastic leukemia: clinical outcome and cost-effectiveness analysis.
This study evaluated the clinical and cost-effectiveness of prophylactic use of fluconazole versus mould-active triazoles (voriconazole and posaconazole) in adult patients with acute lymphoblastic leukemia (ALL). A decision analytical model was developed with inputs from a 7-year retrospective study (2009-2016) of 103 consecutive adult patients with ALL who received antifungal prophylaxis. Information on the administration of antifungal agents, clinical outcomes, and costs were collected. One-way sensitivity analyses and probabilistic sensitivity analysis were performed. The mould-active triazoles group was associated with...
Source: International Journal of Hematology - October 13, 2017 Category: Hematology Authors: Wang Y, Xing Y, Chen L, Meng T, Li Y, Xie J, Chen L, Dong Y, Dong W Tags: Int J Hematol Source Type: research

Dasatinib-associated reversible demyelinating peripheral polyneuropathy in a case of chronic myeloid leukemia.
We report a patient with CML who developed acute onset of DPN associated with dasatinib therapy. A 46-year-old Japanese woman was treated with dasatinib for 7 months after the diagnosis of CML and she achieved a major molecular response (MMR). However, dysphagia, hoarseness, and muscle weakness progressively developed over 2 weeks. Nerve conduction studies revealed extensive demyelinating changes. Dasatinib was discontinued and the patient received intravenous immunoglobulin (IVIg), resulting in resolution of the symptoms. However, 1 month after the re-initiation of dasatinib therapy, muscle weakness develop...
Source: International Journal of Hematology - October 13, 2017 Category: Hematology Authors: Ishida T, Akagawa N, Miyata T, Tominaga N, Iizuka T, Higashihara M, Suzuki T, Miyazaki K Tags: Int J Hematol Source Type: research

Prognostic value of genetic mutations in adolescent and young adults with acute myeloid leukemia.
Usui N, Kanamori H, Ito Y, Imai K, Suehiro Y, Kobayashi S, Kitamura K, Sakaida E, Ogawa S, Naoe T, Hayashi Y, Horibe K, Manabe A, Mizutani S, Adachi S, Kiyoi H Abstract Clinical outcomes and the genetic background of acute myeloid leukemia (AML) in adolescent and young adults (AYAs) are known to differ in younger children and older adults. To clarify the impact of genetic mutations on clinical outcomes of AYAs with AML, we analyzed data from the JPLSG AML-05 and JALSG AML201 studies. AYAs aged 15-39 years (n = 103) were included. FLT3-ITD, KIT, CEBPA, NRAS, KRAS, WT1, MLL-PTD, and NPM1 mutations wer...
Source: International Journal of Hematology - October 12, 2017 Category: Hematology Authors: Kuwatsuka Y, Tomizawa D, Kihara R, Nagata Y, Shiba N, Iijima-Yamashita Y, Shimada A, Deguchi T, Miyachi H, Tawa A, Taga T, Kinoshita A, Nakayama H, Kiyokawa N, Saito AM, Koh K, Goto H, Kosaka Y, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Tags: Int J Hematol Source Type: research

Anemia and hypogammaglobulinemia caused by M énétrier's disease.
Anemia and hypogammaglobulinemia caused by Ménétrier's disease. Int J Hematol. 2017 Oct 12;: Authors: Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N PMID: 29027113 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 12, 2017 Category: Hematology Authors: Imataki O, Uchida S, Yokokura S, Uemura M, Kadowaki N Tags: Int J Hematol Source Type: research

Immature platelet fraction (IPF) as a predictive value for thrombopoietic recovery after allogeneic stem cell transplantation.
Abstract We consecutively examined the utility of measurements of percentage of immature platelet fraction (IPF%) and absolute IPF number (A-IPF) in predicting thrombopoietic recovery in 15 adult patients who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT). Four patients were excluded from the evaluation due to insufficient data. Platelet count and IPF were measured by Sysmex XN-1000 (XN), a newer generation analyzer. First, we confirmed that platelet count measured by XN was more accurate than by XE-2100 (XE). IPF measurement was effective to predict the recovery in 7 of the 11 patients ex...
Source: International Journal of Hematology - October 12, 2017 Category: Hematology Authors: Sakuragi M, Hayashi S, Maruyama M, Kiyokawa T, Nagamine K, Fujita J, Maeda T, Kato H, Kashiwagi H, Kanakura Y, Tomiyama Y Tags: Int J Hematol Source Type: research

TAK1 inhibition ameliorates survival from graft-versus-host disease in an allogeneic murine marrow transplantation model.
Abstract Acute graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic cell transplantation (allo-HCT). Majority of the current immunosuppressive strategies targeting donor T cells to prevent or treat acute GVHD are only partially effective, and often require escalated immunosuppressive therapy. Recent studies have revealed that activation of antigen-presenting cells in the proinflammatory milieu is important for the priming and promotion of GVHD. This activation is mediated by innate immune signaling pathways, which therefore potentially represent new tar...
Source: International Journal of Hematology - October 12, 2017 Category: Hematology Authors: Kobayashi A, Kobayashi S, Miyai K, Osawa Y, Horiuchi T, Kato S, Maekawa T, Yamamura T, Watanabe J, Sato K, Tsuda H, Kimura F Tags: Int J Hematol Source Type: research

Correction to: JSH guideline for tumors of hematopoietic and lymphoid tissues-lukemia: 4. Chronic myelogenous leukemia (CML)/myeloproliferative neoplasms (MPN).
Abstract In the original publication of this article, the "Acknowledgements" was not included and it is given below for your reading. PMID: 29027146 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - October 12, 2017 Category: Hematology Authors: Usui N Tags: Int J Hematol Source Type: research

Increased mean platelet volume (MPV) is an independent predictor of inferior survival in patients with primary and secondary myelofibrosis.
Abstract Neoplastic megakaryopoiesis is a dominant feature of Philadelphia-chromosome-negative myeloproliferative neoplasms (Ph- MPNs), and elevated mean-platelet-volume (MPV) is a common finding in these diseases. The clinical and prognostic significances of MPV in patients with primary (PMF) and secondary myelofibrosis (SMF) have not been reported. We retrospectively analyzed 87 patients with myelofibrosis (66 with PMF, 21 with SMF) treated at our institution. MPV was recorded in addition to other hematological and clinical parameters. MPV was elevated in both PMF and SMF patients in comparison to controls, wher...
Source: International Journal of Hematology - October 11, 2017 Category: Hematology Authors: Lucijanic M, Mitrovic Z, Cicic D, Prka Z, Pejsa V, Livun A, Stoos-Veic T, Romic Z, Zivkovic M, Lucijanic I, Fabris Z, Kusec R Tags: Int J Hematol Source Type: research

Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue.
Abstract Doxorubicin (Dox) is an effective anticancer drug with known activity against a wide spectrum of malignancies, hematologic malignancies in particular. Despite extensive clinical use, the mechanisms of its side effects and negative action on normal cells remain under study. The aim of this study was to investigate the effect of Dox on cultured human mesenchymal stem cells (MSCs) derived from menstrual blood (eMSCs), bone marrow (BMSCs) and adipose tissue (AMSCs). Dox treatment in high doses decreased the survival of MSCs in a dose-dependent manner. Clinically relevant low doses of Dox induced premature sen...
Source: International Journal of Hematology - October 11, 2017 Category: Hematology Authors: Kozhukharova I, Zemelko V, Kovaleva Z, Alekseenko L, Lyublinskaya O, Nikolsky N Tags: Int J Hematol Source Type: research

Analysis of five cases of human herpesvirus-6 myelitis among 121 cord blood transplantations.
Abstract Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. The major symptom identified in all five patients was superficial pain or pruritus linked to segmental levels of the spinal cord. Other identified symptoms were fever or low-grade fever in all five patients, autonomic nerve disorder in four patients, bladder and rectal disturbance in two patients, and extrapyramidal disorder in t...
Source: International Journal of Hematology - October 11, 2017 Category: Hematology Authors: Ueki T, Hoshi K, Hiroshima Y, Sumi M, Ichikawa N, Ogata M, Satou T, Fukuda T, Kobayashi H Tags: Int J Hematol Source Type: research

Comparison of fluorine-18 fluorodeoxyglucose positron emission tomography with gallium-67 scintigraphy in the initial clinical staging of diffuse large B-cell lymphoma.
In this study, we retrospectively compared staging and treatment outcomes of newly diagnosed diffuse large B-cell lymphoma (DLBCL) assessed by PET (n = 153) or gallium-67 scintigraphy (Ga) (n = 95). In total, Ga upstaged two (2.1%) of 95 patients, whereas PET upstaged 13 (8.5%) of 153 patients. Bone/bone marrow (15 vs. 4%, P = 0.01) and muscle lesion (5 vs. 0%, P = 0.03) were identified more frequently in the PET group than in the Ga group. The estimated 3-year overall and progression-free survival rates did not differ significantly in the two groups at any stage. However, patients w...
Source: International Journal of Hematology - October 9, 2017 Category: Hematology Authors: Sakurai M, Toyama T, Kikuchi T, Kato J, Shimizu T, Koda Y, Karigane D, Yamane Y, Abe R, Yamazaki R, Nakazato T, Nakahara T, Jinzaki M, Okamoto S, Mori T Tags: Int J Hematol Source Type: research

Quantification of Wilms' tumor 1 mRNA by digital polymerase chain reaction.
Abstract Wilms' tumor 1 (WT1) is overexpressed in various hematopoietic tumors and widely used as a marker of minimal residual disease. WT1 mRNA has been analyzed using quantitative real-time polymerase chain reaction (real-time PCR). In the present study, we analyzed 40 peripheral blood and bone marrow samples obtained from cases of acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome at Sapporo Medical University Hospital from April 2012 to January 2015. We performed quantification of WT1 was performed using QuantStudio 3D Digital PCR System (Thermo Fisher Scientific‎) and compa...
Source: International Journal of Hematology - October 9, 2017 Category: Hematology Authors: Koizumi Y, Furuya D, Endo T, Asanuma K, Yanagihara N, Takahashi S Tags: Int J Hematol Source Type: research

Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis.
Abstract Ruxolitinib, a potent JAK1/JAK2 inhibitor, improved splenomegaly and myelofibrosis-associated symptoms and prolonged survival compared with placebo and best available therapy in the phase 3 COMFORT studies. Although cytopenias were the most common adverse events associated with ruxolitinib treatment, a COMFORT-I analysis showed that they were managed effectively with dose modifications, without a negative impact on the efficacy of ruxolitinib. Subsequently, studies A2202 and AJP01 showed that ruxolitinib is an effective treatment for Japanese patients with myelofibrosis. We conducted a pooled analysis of ...
Source: International Journal of Hematology - October 6, 2017 Category: Hematology Authors: Kirito K, Okamoto S, Ohishi K, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Oritani K, Akashi K, Okada H, Amagasaki T, Suzuki K, Yonezu T, Komatsu N Tags: Int J Hematol Source Type: research

Ruxolitinib is effective and safe in Japanese patients with hydroxyurea-resistant or hydroxyurea-intolerant polycythemia vera with splenomegaly.
We report findings from a subgroup analysis of Japanese patients in RESPONSE (n = 18). The composite response rate (hematocrit control and spleen response) was higher in patients receiving ruxolitinib (50.0%) than in those receiving BAT (8.3%). A total of 50.0% of patients randomized to ruxolitinib achieved a spleen response vs 8.3% of those receiving BAT; 100 and 33.3% of patients in the respective groups achieved hematocrit control, with mean hematocrit in ruxolitinib-treated patients remaining stable at
Source: International Journal of Hematology - September 27, 2017 Category: Hematology Authors: Kirito K, Suzuki K, Miyamura K, Takeuchi M, Handa H, Okamoto S, Gadbaw B, Yamauchi K, Amagasaki T, Ito K, Hino M Tags: Int J Hematol Source Type: research

Persistent changes in circulating white blood cell populations after splenectomy.
Abstract The effect of splenectomy on the incidence of infections and thromboembolisms has been investigated thoroughly. Nevertheless, the long-term effects of splenectomy on immunological profile and circulating blood counts have not been described before. To study such long-term effects, we analysed several parameters in splenectomised trauma patients and compared the results of this group ("otherwise healthy patients") to patients with a specific underlying disease. We measured platelet count, leukocytes and differential, lymphocyte subsets, serum levels of immunoglobulins, and complement pathways in ...
Source: International Journal of Hematology - September 26, 2017 Category: Hematology Authors: Rab MAE, Meerveld-Eggink A, van Velzen-Blad H, van Loon D, Rijkers GT, de Weerdt O Tags: Int J Hematol Source Type: research

JSH guideline for tumors of hematopoietic and lymphoid tissues-lukemia: 4. Chronic myelogenous leukemia (CML)/myeloproliferative neoplasms (MPN).
PMID: 28936634 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - September 21, 2017 Category: Hematology Authors: Usui N Tags: Int J Hematol Source Type: research

Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study.
The objective of this prospective clinical trial (JALSG-STIM213, UMIN000011971) was to evaluate treatment-free remission (TFR) rates after discontinuation of imatinib in chronic myeloid leukemia (CML). CML patients who received imatinib treatment for at least 3 years and sustained deep molecular response for at least 2 years were eligible. Molecular recurrence was defined as loss of major molecular response (MMR). Of the 68 eligible patients, 38.2% were women, the median age was 55.0 years, and the median duration of imatinib treatment was 97.5 months. The 12-month TFR rate was 67.6%. Patients who lost ...
Source: International Journal of Hematology - September 19, 2017 Category: Hematology Authors: Takahashi N, Tauchi T, Kitamura K, Miyamura K, Saburi Y, Hatta Y, Miyata Y, Kobayashi S, Usuki K, Matsumura I, Minami Y, Usui N, Fukuda T, Takada S, Ishikawa M, Fujimaki K, Gomyo H, Sasaki O, Ohishi K, Miyake T, Imai K, Suzushima H, Mitsui H, Togitani K, Tags: Int J Hematol Source Type: research

Distribution of malignant lymphomas in the anterior mediastinum: a single-institution study of 76 cases in Japan, 1997-2016.
Abstract We analyzed the distribution of tumors and lymphomas of the anterior mediastinum diagnosed between 1997 and 2016 at the National Cancer Center Hospital, Japan. The median age of 283 patients with anterior mediastinal tumors was 48 (range 6-84) years, and 143 (51%) were male. The incidence of tumors was as follows: thymoma, 34%; thymic carcinoma, 16%; primary mediastinal large B-cell lymphoma (PMBL), 13%; germ cell tumors, 10%; classical Hodgkin lymphoma (CHL), 9%; thymic cyst, 7%; metastatic tumors, 3%; T lymphoblastic leukemia/lymphoma (T-LBL), 2%; other lymphomas, 3%; and others, 3%. Of the newly diagno...
Source: International Journal of Hematology - September 18, 2017 Category: Hematology Authors: Maeshima AM, Taniguchi H, Suzuki T, Yuda S, Toyoda K, Yamauchi N, Makita S, Fukuhara S, Munakata W, Maruyama D, Kobayashi Y, Tobinai K Tags: Int J Hematol Source Type: research

Phase I study of panobinostat and 5-azacitidine in Japanese patients with myelodysplastic syndrome or chronic myelomonocytic leukemia.
Abstract The current therapy for high-risk myelodysplastic syndrome (MDS) involves repeated cycles of the DNA demethylating agent 5-azacitidine (5-Aza), but combination treatments have been proposed to improve patient outcomes. We performed a phase Ib study to investigate the safety and tolerability of 5-Aza (75 mg/m(2)) combined with the histone deacetylase inhibitor panobinostat (PAN) in adult Japanese patients with MDS or chronic myelomonocytic leukemia (CMML). Eleven patients were enrolled; five received 20 mg PAN + 5-Aza and six received 30 mg PAN + 5-Aza. All patients in th...
Source: International Journal of Hematology - September 13, 2017 Category: Hematology Authors: Kobayashi Y, Munakata W, Ogura M, Uchida T, Taniwaki M, Kobayashi T, Shimada F, Yonemura M, Matsuoka F, Tajima T, Yakushijin K, Minami H Tags: Int J Hematol Source Type: research

Effect of rituximab on primary central nervous system lymphoma: a meta-analysis.
Abstract The effect of rituximab on primary central nervous system lymphoma (PCNSL) is controversial. We performed this meta-analysis to assess the efficacy of treatment with or without rituximab for PCNSL. We first conducted a search for qualified studies using PubMed, the Cochrane Library, and the Web of Science. The meta-analysis was conducted to compare odds ratios (ORs) with the corresponding 95% confidence interval (95% CI) for complete remission (CR) rate, progression-free survival (PFS), and overall survival (OS) using Review Manager 5.0. We included two randomized clinical trials and six retrospective stu...
Source: International Journal of Hematology - September 12, 2017 Category: Hematology Authors: Song Y, Wen Y, Xue W, Zhang Y, Zhang M Tags: Int J Hematol Source Type: research

The infiltration of classical Hodgkin lymphoma cells into pleural effusion.
PMID: 28900852 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - September 12, 2017 Category: Hematology Authors: Kito M, Munakata W, Ono K, Maeshima AM, Matsushita H Tags: Int J Hematol Source Type: research

Modified immunosuppressive therapy with porcine antilymphocyte globulin plus delayed cyclosporine A in children with severe aplastic anemia.
Abstract Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less expensive and more effective than rabbit ATG, is widely used. We sought to evaluate the efficacy and safety profile of modified IST with p-ALG plus delayed CsA at day 21 in 50 SAA children. Eighteen SAA patients who progressed from nonsevere aplastic anemia (NSAA) were classified as SAA-II; the ...
Source: International Journal of Hematology - September 12, 2017 Category: Hematology Authors: Cui Q, Sha P, Chen H, Shen H, Qin L, Li Z, Wu T, Wang Z Tags: Int J Hematol Source Type: research

Splenectomy vs. rituximab as a second-line therapy in immune thrombocytopenic purpura: a single center experience.
Abstract Immune thrombocytopenic purpura (ITP) is a common hematological disease treated primarily by corticosteroids. The aim of the present study was to compare response rate between patients, underwent splenectomy vs. rituximab as second-line therapy. Adult patients diagnosed with ITP who did not respond to corticosteroids or relapsed during the period 1990-2014 were included in a quasi-experimental study. Categorical variables were compared using Fisher exact test. Response to treatment was compared using logistic regression. Data were analyzed using SAS V9.2. One-hundred and forty-three patients with ITP were...
Source: International Journal of Hematology - September 11, 2017 Category: Hematology Authors: Al Askar AS, Shaheen NA, Al Zahrani M, Al Otaibi MG, Al Qahtani BS, Ahmed F, Al Zughaibi M, Kamran I, Mendoza MA, Khan A Tags: Int J Hematol Source Type: research

Megakaryoblastic transformation of therapy-related myeloid neoplasms with concomitant MYC amplification on double minute chromosomes.
PMID: 28884443 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - September 7, 2017 Category: Hematology Authors: Yamamoto K, Yakushijin K, Inui Y, Kawamoto S, Kajimoto K, Hayashi Y, Matsuoka H, Minami H Tags: Int J Hematol Source Type: research

Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction.
This study examined relationships between valproate (VPA) and platelet count and immature platelet fraction (IPF). We compared the platelet count and IPF among three groups of children: those treated with VPA, those treated with other antiepileptic drugs (AEDs), and a reference group. IPF was measured using flow cytometry, and absolute immature platelet count (A-IPC) was calculated. The platelet count was significantly lower in the VPA group than in other AED and reference groups. In all groups, IPF was negatively correlated with platelet count. IPF was significantly higher in the VPA group than in the reference group, whe...
Source: International Journal of Hematology - September 6, 2017 Category: Hematology Authors: Kurahashi H, Takami A, Murotani K, Numoto S, Okumura A Tags: Int J Hematol Source Type: research

Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma.
This study provides the first evidence for the association of IKZF1 variants with DLBCL outcome. PMID: 28879630 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - September 6, 2017 Category: Hematology Authors: Bielska M, Borowiec M, Jesionek-Kupnicka D, Braun M, Bojo M, Pastorczak A, Kalinka-Warzocha E, Prochorec-Sobieszek M, Robak T, Warzocha K, Młynarski W, Lech-Marańda E Tags: Int J Hematol Source Type: research

Eltrombopag for thrombocytopenia in patients with advanced solid tumors receiving gemcitabine-based chemotherapy: a randomized, placebo-controlled phase 2 study.
Abstract In this phase 2 study, patients with solid tumors receiving gemcitabine monotherapy or gemcitabine plus cisplatin/carboplatin were randomized 2:1 to eltrombopag 100 mg (n = 52) or placebo (n = 23) for 5 days before and after chemotherapy was started. The primary endpoint was prechemotherapy (Day 1) platelet count across ≤6 cycles. Prechemotherapy platelet counts were numerically higher with eltrombopag than placebo. Frequencies of grades 3/4 thrombocytopenia were lower with eltrombopag in both the combination therapy (77 vs. 100%) and monotherapy (36 vs. 42%) groups. Propo...
Source: International Journal of Hematology - September 1, 2017 Category: Hematology Authors: Winer ES, Safran H, Karaszewska B, Bauer S, Khan D, Doerfel S, Burgess P, Kalambakas S, Mostafa Kamel Y, Forget F Tags: Int J Hematol Source Type: research

Autologous hematopoietic stem cell transplantation may improve long-term outcomes in patients with newly diagnosed extranodal natural killer/T-cell lymphoma, nasal type: a retrospective controlled study in a single center.
Abstract Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare disease with a poor prognosis. The long-term effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on ENKTL has been reported occasionally but needs further investigation. In this retrospective study from a single center, 20 ENKTL patients who received induction chemotherapy followed by auto-HSCT ± involved-field radiotherapy (IFRT) ± additional chemotherapy were enrolled as a study group. Another 60 fit ENKTL patients who received induction chemotherapy ± IFRT ...
Source: International Journal of Hematology - August 30, 2017 Category: Hematology Authors: Wang J, Wei L, Ye J, Yang L, Li X, Cong J, Yao N, Cui X, Wu Y, Ding J, Zhang L Tags: Int J Hematol Source Type: research

JSH guideline for tumors of hematopoietic and lymphoid tissues: leukemia: 2. Acute promyelocytic leukemia (APL).
PMID: 28856623 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 30, 2017 Category: Hematology Authors: Asou N, Fujita H, Shinagawa K Tags: Int J Hematol Source Type: research

Recent trends in practice patterns and comparisons between immunoglobulin and corticosteroid in pediatric immune thrombocytopenia.
Abstract The clinical benefits and practice patterns of different pharmacologic regimes in acute pediatric immune thrombocytopenia (ITP) remain unclear in Japan. Using a national inpatient database, we analyzed recent trends in practice patterns for acute pediatric ITP, and compared risks of 6-month readmission, total hospitalization costs, and lengths of hospital stay between ITP children treated with intravenous immunoglobulin (IVIG) and corticosteroid, using inverse probability weighting analyses. From 2010 to 2014, the proportions of IVIG use increased from 43.4 to 66.0% (P trend 
Source: International Journal of Hematology - August 28, 2017 Category: Hematology Authors: Okubo Y, Michihata N, Morisaki N, Hangai M, Matsui H, Fushimi K, Yasunaga H Tags: Int J Hematol Source Type: research

Toxicological effects of fludarabine and treosulfan conditioning before allogeneic stem-cell transplantation.
This study shows that early regimen-related toxicity after HSCT was low despite similar marrow toxicities compared to myeloablative regimens. PMID: 28849374 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 28, 2017 Category: Hematology Authors: Remberger M, Törlen J, Serafi IE, Garming-Legert K, Björklund A, Ljungman P, Sundin M, Hassan M, Mattsson J Tags: Int J Hematol Source Type: research

Imbalanced expression of polycistronic miRNA in acute myeloid leukemia.
Abstract miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines. Interestingly, the expression of miR-1 and EVI1, which binds to the promoter of the miR...
Source: International Journal of Hematology - August 22, 2017 Category: Hematology Authors: Kotaki R, Higuchi H, Ogiya D, Katahira Y, Kurosaki N, Yukihira N, Ogata J, Yamamoto H, Mohamad Alba S, Azhim A, Kitajima T, Inoue S, Morishita K, Ono K, Koyama-Nasu R, Kotani A Tags: Int J Hematol Source Type: research

Infectious complications in multiple myeloma receiving autologous stem cell transplantation in the past 10  years.
In conclusion, infection was the main cause of in-hospital mortality in patients who underwent autoSCT. Bacteremia was the most common type of microbiologically confirmed infection, and was associated with higher beta-2 microglobulin levels and previous bortezomib treatment. PMID: 28825207 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 20, 2017 Category: Hematology Authors: Park H, Youk J, Kim HR, Koh Y, Kwon JH, Yoon SS, Park S, Choe PG, Kim NJ, Oh MD, Park WB, Kim I Tags: Int J Hematol Source Type: research

Risk factors in patients undergoing haploidentical hematopoietic stem cell transplantation for high-risk childhood acute leukemia.
Abstract In the present study, we sought to analyze the risk factors following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in children with high-risk acute leukemia. We retrospectively reviewed data from 73 children with high-risk leukemia. Univariate and multivariate analyses were performed to evaluate relationships between variables and patient outcomes. The mean time for neutrophil engraftment was significantly shorter in children given a graft with a higher number of nucleated cells (>10.13 × 108/kg vs ≤10.13 × 108/kg: 13.79 ± 2.73 ...
Source: International Journal of Hematology - August 20, 2017 Category: Hematology Authors: Han DM, Zheng XL, Ding L, Yan HM, Wang ZD, Xue M, Zhu L, Liu J, Wang HX Tags: Int J Hematol Source Type: research

Successful management of a hydropic fetus with severe anemia and thrombocytopenia caused by anti-CD36 antibody.
This report suggests that intrauterine transfusions with compatible RBC and CD36null platelets are useful in preventing the deleterious clinical effects of anti-CD36-mediated severe FNAIT. PMID: 28815406 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 16, 2017 Category: Hematology Authors: Xu X, Li L, Xia W, Ding H, Chen D, Liu J, Deng J, Chen Y, He Z, Wang J, Shao Y, Santoso S, Ye X, Fang Q Tags: Int J Hematol Source Type: research

Efficacy and safety of a 4-factor prothrombin complex concentrate for rapid vitamin K antagonist reversal in Japanese patients presenting with major bleeding or requiring urgent surgical or invasive procedures: a prospective, open-label, single-arm phase 3b study.
Abstract Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; Beriplex(®)/Kcentra(®)) was shown in two large randomized controlled, international phase 3b trials to be an effective alternative to plasma for urgent VKA reversal. In the present prospective, open-label, single-arm phase 3b trial, we evaluate the efficacy and safety of 4F-PCC in Japanese patients. Eleven patients [international normalized ratio (INR) ≥2] requiring rapid VKA reversal owing to major bleeding (n =&nbs...
Source: International Journal of Hematology - August 16, 2017 Category: Hematology Authors: Kushimoto S, Fukuoka T, Kimura A, Toyoda K, Brainsky A, Harman A, Chung T, Yasaka M Tags: Int J Hematol Source Type: research

Availability of angiography and therapeutic embolization for the treatment of acute bleeding in patients with hemophilia.
Abstract Clotting factor replacement therapy alone is often inadequate for acute bleeding in hemophilia patients, and surgery for such patients poses significant clinical challenges. Arterial angiographic intervention is used to control bleeding in local blood vessels. In the present study, we examined the clinical course and prognosis of hemophilia patients with bleeding who had undergone angiography, and evaluated the validity of diagnostic angiography and therapeutic embolization in these patients. Angiography was performed in five hemophilia patients, who experienced bleeding that was difficult to control even...
Source: International Journal of Hematology - August 16, 2017 Category: Hematology Authors: Kim MJ, Oh JY, Park YS Tags: Int J Hematol Source Type: research

Effect of sertraline on complications and survival after hematopoietic stem-cell transplantation, a double-blind, placebo-controlled clinical study.
This study provides evidence that sertraline positively influences engraftment time, readmission, and mortality after HSCT. PMID: 28815419 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 16, 2017 Category: Hematology Authors: Tavakoli-Ardakani M, Kheshti R, Maryam M Tags: Int J Hematol Source Type: research

NKG2D gene polymorphisms are associated with disease control of chronic myeloid leukemia by dasatinib.
Abstract A recent study reported that treatment-free remission (TFR) of chronic myeloid leukemia (CML) after dasatinib (Das) treatment was significantly associated with natural killer (NK) cell proliferation in the peripheral blood. However, biomarkers to predict lymphocytosis or successful TFR are not well characterized. In order to clarify individual differences in NK cell responses among patients treated with Das, we retrospectively analyzed the association between polymorphisms in the natural killer group 2D receptor [NKG2D; also known as killer cell lectin like receptor K1 (KLRK1)] gene and clinical outcomes ...
Source: International Journal of Hematology - August 9, 2017 Category: Hematology Authors: Hara R, Onizuka M, Matsusita E, Kikkawa E, Nakamura Y, Matsushita H, Ohgiya D, Murayama H, Machida S, Ohmachi K, Shirasugi Y, Ogawa Y, Kawada H, Ando K Tags: Int J Hematol Source Type: research

High-resolution melting analysis for prenatal diagnosis of beta-thalassemia in northern Thailand.
Abstract High-resolution melting (HRM) analysis is a rapid mutation analysis which assesses the pattern of reduction of fluorescence signal after subjecting the amplified PCR product with saturated fluorescence dye to an increasing temperature. We used HRM analysis for prenatal diagnosis of beta-thalassemia disease in northern Thailand. Five PCR-HRM protocols were used to detect point mutations in five different segments of the beta-globin gene, and one protocol to detect the 3.4 kb beta-globin deletion. We sought to characterize the mutations in carriers and to enable prenatal diagnosis in 126 couples at ris...
Source: International Journal of Hematology - August 8, 2017 Category: Hematology Authors: Charoenkwan P, Sirichotiyakul S, Phusua A, Suanta S, Fanhchaksai K, Sae-Tung R, Sanguansermsri T Tags: Int J Hematol Source Type: research

Achievement of the longest survival of paraneoplastic pemphigus with bronchiolitis obliterans associated with follicular lymphoma using R-CHOP chemotherapy.
Abstract Paraneoplastic pemphigus (PNP) is a rare, fatal, paraneoplastic autoimmune mucocutaneous blistering disease, commonly associated with lymphoproliferative disorders, including malignant lymphomas. Lymphoproliferative disorders associated with PNP are sometimes associated with a serious lung complication, bronchiolitis obliterans (BO). Due to its rarity, guidelines for the management of PNP have not been established. Furthermore, most patients die within 1 year. Here we report the successful treatment of lymphoma-associated PNP and BO using R-CHOP chemotherapy. A 53-year-old Japanese man was admitted t...
Source: International Journal of Hematology - August 8, 2017 Category: Hematology Authors: Lee S, Yamauchi T, Ishii N, Hashimoto T, Kinoshita K, Imamura S, Kamiya K Tags: Int J Hematol Source Type: research

JSH guideline for tumors of hematopoietic and lymphoid tissues: leukemia 1. Acute myeloid leukemia (AML).
PMID: 28786079 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)
Source: International Journal of Hematology - August 7, 2017 Category: Hematology Authors: Miyawaki S Tags: Int J Hematol Source Type: research

Hydroxyurea for hemoglobin E/ β-thalassemia: a systematic review and meta-analysis.
Hydroxyurea for hemoglobin E/β-thalassemia: a systematic review and meta-analysis. Int J Hematol. 2017 Aug 07;: Authors: Algiraigri AH, Kassam A Abstract Hemoglobin E-beta thalassemia (Hb E/β-thalassemia) is a distinct, yet common, type of β-thalassemia, in which the patient co-inherits a β-thalassemia allele from one parent, and a structural variant, Hb E, from the other parent. This co-inheritance leads to remarkable clinical heterogeneity, varying degrees of chronic anemia, and a wide spectrum of complications due to ineffective erythropoiesis and iron overload. Hydroxyurea (HU)...
Source: International Journal of Hematology - August 7, 2017 Category: Hematology Authors: Algiraigri AH, Kassam A Tags: Int J Hematol Source Type: research