Identification of Prognostic Biomarkers for Clear Cell Renal Cell Carcinoma (ccRCC) by Transcriptomics
Ann Clin Lab Sci. 2021 Sep;51(5):597-608.ABSTRACTOBJECTIVE: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of renal malignancies. Our aim was to find the prognostic crux of ccRCC.METHODS: The data for ccRCC was acquired from The Cancer Genome Atlas (TCGA) and the International Genome Consortium (ICGC) database. Weighted gene co-expression network analysis (WGCNA), differentially expressed genes (DEGs), and univariate Cox analysis were applied to classify the gene groups. A Venn diagram was used to find the intersection of the gene groups. The prognostic efficiency was proved by Kaplan-Meier an...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Sihong Zhang Xianglai Xu Yelin Wang Yanjun Zhu Jiajun Wang Hang Wang Jianming Guo Source Type: research

Obesity Is a Risk Factor Associated with < em > H. pylori < /em > -negative MALT Lymphoma of Stomach
CONCLUSION: Obesity leads to a baseline state of chronic inflammation and increased production of pro-inflammatory cytokines that can stimulate the lymphocytes, leading to lymphomatous proliferation. Our study suggests a potential correlation between obesity and the risk of development of primary gastric MALT lymphoma.PMID:34686502 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Brenda Mai Michaelangelo Friscia Shaimaa Elzamly Jaiyeola Thomas-Ogunniyi Amer Wahed Andy Nguyen Zhihong Hu Zhenjian Cai Lei Chen Source Type: research

The Diagnostic and Prognostic Value of LIMK1/2: A Pan-Cancer Analysis
CONCLUSION: The results provide a comprehensive insight into LIMK1 and LIMK2 in multiple cancers and as novel therapeutic targets for cancer treatment.PMID:34686503 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Ju Li Yun Liu Lian Zheng Source Type: research

miR-145-5p Modulates Gefitinib Resistance by Targeting NRAS and MEST in Non-Small Cell Lung Cancer
CONCLUSION: miR-145-5p improves the sensitivity of acquired gefitinib-resistant cells to gefitinib via inhibiting NRAS and MEST expression. The miR 145-5p-NRAS/MEST axis in NSCLC provides insights for the development of a NRAS/MEST targeting therapeutic approach to overcome gefitinib resistance in NSCLC patients.PMID:34686504 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Chuigong Yu Bingqing Li Jinghao Wang Ziyue Zhang Shengjing Li Shixiong Lei Qinhao Wang Source Type: research

Predictive Value of let-7a for Cancer Cell Repopulation between Chemotherapy and Long-Term Survival: A Prospective Study
Ann Clin Lab Sci. 2021 Sep;51(5):638-645.ABSTRACTOBJECTIVE: Repopulation during radiation is a classic theory in radiobiology. The long intervals between cycles of chemotherapy provide better micro-circumstance than radiation for the repopulation of cancer cells.METHODS: Patients with inoperable stage III and stage IV lung cancer were enrolled prospectively. Peripheral blood and tumor tissues were obtained before treatment and each cycle of chemotherapy to detect the serum let-7a expression and Ki-67 index.RESULTS: Fifty-two consecutive consenting patients were enrolled prospectively. The median follow-up was 13 months (ra...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Xueqi Xie Dongdong Du Yan Guan Tong Jin Jinlong Chen Qian Wang Dapeng Li Yinsheng Xie Naifu Liu Peng Xie Source Type: research

The Effect and Potential Mechanism of microRNA-124 on the Biological Behavior of Colon Cancer Cells
Ann Clin Lab Sci. 2021 Sep;51(5):646-653.ABSTRACTOBJECTIVE: We aimed to investigate the expression of microRNA-124 (miR-124) in colon cancer and its biological function in colon cancer cells as well as its underlying mechanism.METHODS: Mimic miR-124 and unrelated sequence were transfected into colon cancer HT29 cells, and a blank control group was established with untreated HT29 cells. The expression of miR-124 in each group was detected by qRT-PCR. CCK-8 assay, cell scratch assay, Transwell assay, and flow cytometry were used to detect the effects of miR-124 on cell growth, invasion, migration, and apoptosis in HT29 cells...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Gang Zhou Source Type: research

Long Non-Coding RNA SNHG4 Is a Potential Diagnostic and Prognostic Indicator in Non-Small Cell Lung Cancer
Ann Clin Lab Sci. 2021 Sep;51(5):654-662.ABSTRACTOBJECTIVE: The mortality rate of non-small cell lung cancer ranks first worldwide. The lack of effective and accurate diagnosis contributes to the unfavorable prognosis of non-small cell lung cancer patients since most of them are diagnosed at an advanced stage. In the present study, we aimed to investigate whether LncRNA SNHG4 was implicated in predicting non-small cell lung cancer diagnosis and outcomes.METHODS: We collected 68 unpaired serums and tissues from patients with non-small cell lung cancer and from healthy volunteers. Quantitative real-time polymerase chain reac...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Zhong Li Yimeng Zhuo Jieshi Li Minhui Zhang Ruihua Wang Lijing Lin Source Type: research

UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway
CONCLUSION: The knockdown of UGCG exerted an anti-tumor effect against cervical cancer through the inactivation of the PI3K/AKT pathway.PMID:34686508 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Fenyun Zhang Hao Zhang Source Type: research

Multiple Mutation Detection for Risk Assessment in Patients with Breast Cancer by Using Next-Generation Sequencing
CONCLUSION: This study demonstrates the feasibility of using Ion Torrent sequencing technology for reliably detecting gene mutations in clinical practice for guiding individualized drug therapy or combination therapies for breast cancer.PMID:34686509 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Peng-Fei Liu Zhong-Ling Zhuo Fei Xie Hai-Peng Xian Chang Liu Shu Wang Xiao-Tao Zhao Source Type: research

Alterations in MAdCAM1-Positive Mucosal Capillaries and Integrin a4b7-Positive Lymphocytes in Crohn's Disease Treated with Anti-TNF α Biologics
Ann Clin Lab Sci. 2021 Sep;51(5):678-685.ABSTRACTOBJECTIVE: To elucidate the reasons for the decreased effectiveness of Vedolizumab (VDZ) treatment in patients with Crohn's disease (CD) previously treated (CD-T) with anti-TNF-α biologics.METHODS: Immunohistochemical staining was performed on sections of formalin-fixed paraffin-embedded ileocolonic biopsies using antibodies for the mucosal addressin molecule (MAdCAM-1) and Etrolizumab.RESULTS: The mean number of MAdCAM-1 positive capillaries (MAdCAM-1-C) was 3 in controls, 8.5 in CD, 5.37 in CD-T, 5.7 in ulcerative colitis (UC), and 3.1 in lymphocytic colitis (LC) (p=...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Mamoun Younes Andrew W DuPont Brooks D Cash Atilla Ertan Source Type: research

The Clinical Significance of SIRT3 in COVID-19 Patients: A Single Center Retrospective Analysis
CONCLUSION: Serum SIRT3 levels were associated with the clinical outcome and prognosis of COVID-19 patients. However, SIRT3 is not an independent risk factor for severe COVID-19.PMID:34686511 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Peng Zhang Tingting Zhao Wenjie Zhou Source Type: research

Effects of a Pandemic and Isolation on Alcohol and Psychoactive Medication Use in a Population of Rehabilitation and Pain Patients
CONCLUSION: In summary, these findings demonstrate relatively consistent drug use, with decreased positivity for high-risk drugs and dangerous drug combinations. We speculate that monitoring of these patients mitigates the possibility of drug misuse and potential overdose and is in concordance with the goals of these monitoring programs.PMID:34686512 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Amadeo Pesce Raymond Sundyhanata Dennis Ritz Richard Thomas Gregory Ackerman Katie Bollman Source Type: research

Detection of < em > Aspergillus < /em > DNA in BALF by Real-time PCR and Galactomannan Antigen for the Early Diagnosis of Chronic Pulmonary Aspergillosis
In this study, we assessed the clinical value of BALF GM and PCR detection in diagnosing CPA.METHODS: The diagnostic criteria of this study were based on the 2015 ESCMID/ERS guidelines for CPA. Seventy-nine patients with CPA and 74 non-CPA patients were enrolled. Aspergillus DNA in BALF was detected in the patients with CPA.RESULTS: The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of BALF PCR in the CPA group were 87.18%, 89.80%, 87.18%, 89.80%, and 0.89 (95% CI 0.82-0.95), respectively (P
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Feng Ye Peiling Zeng Zhengtu Li Chunmei Tang Wenkuan Liu Danhong Su Yangqing Zhan Shaoqiang Li Source Type: research

MicroRNAs in Fetal Umbilical Cord Blood as a Prenatal Screening Tool for Congenital Heart Disease
This study aimed to evaluate the predicted performance of miRNAs in fetal umbilical cord blood for detecting congenital heart disease (CHD).METHODS: In this retrospective cohort study, a total of 60 pregnant women (involving 30 fetuses with CHD and 30 normal fetuses requiring induction of labor) were included. Umbilical cord blood was collected for miRNA measurement. Expression levels of the miRNAs were detected by qRT-PCR. The predictive accuracy of miRNA was assessed by constructing a receiver operating characteristic (ROC) curve and evaluated by calculating the area under the curve (AUC). The point biserial correlation ...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Dexuan Kong Huidong Li Chenchun Ren Weiwei Yang Zhikun Zhang Source Type: research

Predictive Value of the Serum Matrix Metalloproteinase-9 Level on Hepatic Encephalopathy in Patients with Chronic Liver Disease
Ann Clin Lab Sci. 2021 Sep;51(5):713-720.ABSTRACTBACKGROUND: Early diagnosis of hepatic encephalopathy (HE) in chronic liver disease (CLD) is difficult clinically.OBJECTIVE: The aim of this study was to evaluate whether serum matrix metalloproteinase-9 (MMP-9) levels could identify early HE in patients with CLD.METHODS: Serum MMP-9 levels in 1,187 patients with CLD were measured at baseline. A total of 1,187 patients with CLD were followed for a mean of 48 months (range: 4-50). The association between MMP-9 and the risk of HE was evaluated by logistic regression analysis and Cox regression analysis.RESULTS: Patients with h...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Lixian Wei Chen Shao Leilei Luo Hongmei He Shuyan Xv Lingling Shi Song Qiu Haoran Gu Chen Zhu Jian Chen Zhaolian Bian Cuihua Lu Source Type: research

The Value of High-Sensitivity C-reactive Protein in Evaluating Myocardial Damage and the Prognosis in Children with Mycoplasmal Pneumonia
Ann Clin Lab Sci. 2021 Sep;51(5):721-725.ABSTRACTOBJECTIVE: To investigate the value of high-sensitivity C-reactive protein (hs-CRP) in evaluating the myocardial damage and prognosis in children with mycoplasmal pneumonia.MATERIALS: A total of 150 children with mycoplasmal pneumonia were selected. According to their serum creatine kinase isoenzyme (CK-MB) level, they were divided into 72 cases of the myocardial damage group and 78 cases of the non-myocardial damage group. Eighty healthy children undergoing physical examination were selected as the control group. The electrocardiography results and serum CK-MB and hs-CRP le...
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Meimei Lai Tao Ai Shuzhe Yang Yongqiong Wei Yao Deng Xia Yu Lei Zhang Source Type: research

Durable Cord Blood Cell Engraftment in a Patient with Severe Aplastic Anemia after a Matched Sibling Bone Marrow Transplantation and an Unrelated Cord Blood Transplantation
CONCLUSION: This study provides evidence that UCB-derived HSCs have a higher capacity for hematopoietic reconstitution, suggesting that UCB plus an HLA-matched sibling donor is a good alternative for older patients with SAA.PMID:34686517 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Zhong-Ling Wei Lai-Quan Huang Yi-Zhi Jiang Jia-Wei Yan Na-Na Wang Dong-Ping Huang Source Type: research

Intracellular Adhesion Molecule-1 (ICAM-1) Levels in Convalescent COVID-19 Serum: A Case Report
CONCLUSIONS: ICAM-1 levels in serum from a recovered COVID-19 patient were highest 5 weeks after the initial COVID-19 diagnosis. The presence of high levels of soluble markers such as ICAM-1, as measured by the anti-ICAM-1 antibody, may be due to their increased shedding from the cell surface. ICAM-1 may also be a prognostic indicator for late complications or sequelae due to COVD-19 infection.PMID:34686518 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Tamar A Smith-Norowitz Jeffrey Loeffler Yitzchok M Norowitz Stephan Kohlhoff Source Type: research

Clinical Performance of a Gene-Based Machine Learning Classifier in Assessing Risk of Developing OUD in Subjects Taking Oral Opioids: A Prospective Observational Study
CONCLUSION: This study demonstrates an ML classifier may provide additional objective information regarding a patient's risk of developing OUD. This information may enable subjects and healthcare providers to make more informed decisions when considering the use of oral opioids.PMID:34452883 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Keri Donaldson David Cardamone Michael Genovese Joseph Garbely Laurence Demers Source Type: research

A Brief History, the Progress in the Variants of Therapies against Metastatic Neoplasms, and the Role of Pathologists
Ann Clin Lab Sci. 2021 Jul;51(4):461-469.ABSTRACTChemotherapy originated in the early 1960s. The initial chemotherapeutic agents focused on blocking metabolic pathways and found substantial success in certain types of tumors, but they are generally considered toxic to all normal and tumor cells, and they have significant side effects. As more scientific studies began to identify many new, specific targets and mutations, along with a multitude of growth pathways in tumor cells, new agents targeting cell growth pathways began to emerge in the late 1990s and early 2000s. In 2003, a method called morphoproteomics was developed...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Kevin J Zhang Zhenhong Qu Ping L Zhang Robert E Brown Source Type: research

Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1
This study was conducted to explore the effects of Ese-3 on clinical prognosis in skin cancer and the functions of HaCaT cells.MATERIALS AND METHODS: Gene expression and clinical data were collected from The Cancer Genome Atlas (TCGA), The Genotype-Tissue Expression (GTEx), and three GSE datasets (GSE15605, GSE46517, and GSE114445). Comparison of data between groups was performed by Student's t-test and chi square test. Survival analysis was performed using log-rank test. Univariate and multivariate analyses were performed using Cox proportional hazards models. Enrichment analysis was used to predict Ese-3 related function...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Chao Zhang Junqiang Li Yongdong Guo Ronglin Wang Lei Hua Dongxue Gan Liaoliao Zhu Peixiang Ma Jing Yang Hong Li Shanshan Li Yang Song Haichuan Su Source Type: research

Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1
CONCLUSION: Down-regulation of HBXIP reduced Lin28B-mediated NRP-1 to suppress NSCLC cell growth and enhance anti-tumor immunity.PMID:34452886 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lulu Wang Mao Sun Xing Lin Yongyang Lei Zhe Yin Wei Zhou Source Type: research

MiR-643 Functions as a Potential Tumor Suppressor in Gastric Cancer by Inhibiting Cell Proliferation and Invasion < em > via < /em > Targeting TXNDC9
CONCLUSION: miR-643 functions as a potential tumor suppressor in gastric cancer by inhibiting cell viability, colony formation, migration, and invasion via targeting TXNDC9, which provides a novel target for the diagnostic treatment of gastric cancer.PMID:34452887 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Yingxin Wu Huaping Ye Bo Peng Hongmei Jiang Qian Tang Yanjun Liu Juanli Xi Silu Chen Source Type: research

N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF- α Expressions
Ann Clin Lab Sci. 2021 Jul;51(4):503-511.ABSTRACTOBJECTIVE: To compare the e!cacy and functional outcomes of dl-3-n-Butylphthalide (NBP) and human urinary kallidinogenase (HUK) on ischemic stroke patients and to determine their effects on serum tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF).METHODS: A prospective study was conducted on 57 ischemic stroke patients. Functional outcomes were assessed by the National Institute Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the activities of daily living score (ADL), whereas TNF-α and VEGF expressions were measur...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Yijing Guo Idriss Ali Abdoulaye Fei Liu Jiamin Wang Xiuxiu Tian Dafan Yu Kai Le Source Type: research

Association of IL28 B and IL10 Polymorphism with HCV Infection and Direct Antiviral Treatment
This study's findings indicate an independent association of SVR with high basal viral load (P=0.005) and an HCV genotype other than 3 (P=0.001). Patients with viral load log10>6.5 IU/mL required more days to reach an undetectable viral RNA load. The results of the genetic analysis showed a significant association of rs8103142 genotype CC (P
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Kashaf Junaid Hidayat Rasool Ata Ul Mustafa Hasan Ejaz Abdullah Alsrhani Humaira Yasmeen Sonia Younas Abualgasim Elgaili Abdalla Khalid Omer Abdalla Abosalif Sanaa Samir Mohamed Hamam Source Type: research

Fractionated Irradiation Enhances Invasion and Migration by Inducing Epithelial-Mesenchymal Transition and Stemness-Like Properties in A549 Cells
CONCLUSION: Fractionated irradiation could promote epithelial-mesenchymal transition and enhance the migration, invasion, and stemness-like properties in A549 cells, elucidating the possible radioresistance mechanisms of the cancer cells.PMID:34452890 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lisheng Liu Ming Shang Xingguo Song Cong Zhang Wei Guo Source Type: research

Interleukin 2 Ameliorates Autoimmune Neuroinflammation by Modulating the Balance of T Helper 17 Cells and Regulatory T Cells in Mouse
CONCLUSION: Low-dose IL-2 is a potential therapeutic strategy for EAE and MS.PMID:34452891 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Jiannan Li Zhan Zhang Shuang Du Qi Guo Source Type: research

Pandemic-Associated Trends in Measurement of HbA1c in Children with Diabetes Mellitus and Validation of Dried Blood Spot as an Alternative Sample Matrix
CONCLUSION: DBS measurement of HbA1c presents a viable alternative to routine in-person laboratory monitoring of DM.PMID:34452892 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Emily R Garnett Brandy Recio Joanna Jung Estella Tam Sridevi Devaraj Source Type: research

Comparison of < em > Mycoplasma pneumoniae < /em > IgM and IgE Antibody Levels in Asthmatic and Non-Asthmatic Adults
CONCLUSION: IgM M. pneumoniae Abs may play an important role in non-asthma and persist for months after acute infection. IgE M. pneumoniae Abs may play a less important role in both groups.PMID:34452893 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Tamar A Smith-Norowitz Jeffrey Loeffler Yvonne Huang Yitzchok M Norowitz Rauno Joks Stephan Kohlhoff Source Type: research

Factor VIIa-AT Complex Is an Independent Prognostic Marker of Disseminated Intravascular Coagulation
CONCLUSION: The factor VIIa-AT complex reflects the severity of DIC and is an independent prognostic factor of DIC. Our findings hint at the potential of the factor VIIa-AT complex to be used as a complementary marker to well-established biomarkers such as AT.PMID:34452894 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Joon Hee Lee JaYoon Gu Hyun Kyung Kim Source Type: research

The Diagnostic Value of New Additional Antiphospholipid Antibodies in Antiphospholipid Syndrome
Ann Clin Lab Sci. 2021 Jul;51(4):552-556.ABSTRACTBACKGROUND: The antiphospholipid syndrome (APS) is an autoimmune disease that is characterized by thrombosis and/or pregnancy failure and associated with the presence of all or at least one of three standard antibodies (anti-phospholipid (aPL) antibodies, including lupus anticoagulant (LA), anti-cardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI)). A growing body of evidence recommends adding additional aPL antibodies, such as anti-phosphatidylserine (aPS), anti-prothrombin (aPT), and anti-annexin A5 (aAA5), to conventional laboratory tests (revised Sapporo ...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Haitham Khogeer Shatha Altahan Ali Alrehaily Aamir Sheikh Khalid Awartani Murad Al-Kaff Saleh Saleh Hazzaa Alzahrani Areej Alfattani Tarek Owaidah Source Type: research

Serum Albumin to Creatinine Ratio as Predictor for 30-Day All-Cause Mortality in Patients with < em > Clostridium Di!cile- < /em > Associated Diarrhea
CONCLUSION: In this study, it was found that a sACR≤3.4 could predict the 30-day all-cause mortality in patients with CDAD.PMID:34452896 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: William Nseir Jihad Njidat Amir Amara Avi Peretz Hazem Kahatib Amir Mari Mahmud Mahamid Raymond Farah Source Type: research

Sysmex UF-5000 Automatic Urine Sediment Analyzer Can Improve the Accuracy of Epithelial Cell Detection
CONCLUSION: The parameters of the two instruments tested have shown high accuracy, consistency, coincidence rate, and low negative predictive value for RBC and WBC, which has ensured that UF-5000 and UF-1000i meet the clinical requirements for urine tests for disease screening. For the samples with poor consistency and false-positive factors, a conventional microscopic examination should be applied to verify the accuracy of the instrument detection.PMID:34452897 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Yabin Chen Zhishan Zhang Zhenzhong Lin Yibo Wu Yuan Zhao Gangqiang Wang Jing Jing Source Type: research

A Case Report of Fetal Thrombotic Vasculopathy in a COVID Placenta
In conclusion, this case of FTV in the placenta of a patient with COVID-19 is a significant finding, as it can be critical to clinicians in the management of prenatal care for expecting mothers during this pandemic.This case was presented at the annual meeting of the Association of Clinical Scientists (ACS) on May 13, 2021.PMID:34452898 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Brenda Mai Mesk Alrais Amanda Tchakarov Source Type: research

Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic Diagnosis of a Unique Multiclonal Neoplasm
CONCLUSION: This case affirms the histopathologic approach to evaluating composite tumors, as established by the International Neuroblastoma Pathology Classification (INPC) model for ganglioneuroblastoma, nodular tumors. Also, when both components are metastatic, this case demonstrates that composite tumors can be diagnosed by the evaluation of metastatic lesions alone. Finally, it supports the addition of composite neuroblastoma to a future version of the INPC.PMID:34452899 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Justin L Kurtz Hiroyuki Shimada Florette K Hazard Source Type: research

< em > Short Communication: < /em > Stability of Glucose Levels in Serum and Plasma
Ann Clin Lab Sci. 2021 Jul;51(4):580-583.NO ABSTRACTPMID:34452900 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Shabnam Seydafkan Jeremy Minkowitz Geling Li Michael Cabanero Zhenglong Wang Huiying Wang Herol Alexis Ikram Eid Matthew R Pincus Source Type: research

< em > Technical Note: < /em > Glycolic Acid Exacerbates the Analytical Performance of Lactate Assay
In this study, we evaluated the analytical interference of glycolic acid on several lactate assays that use lactate oxidase and dehydrogenase. Herein, we tested the effect of different concentrations of glycolic acid (0.01-46mM) on the lactate assay by using central lab and point of care (POCT) analyzers: Radiometer ABL 800, Beckman AU480, Roche Cobas c502, and Abbott i-STAT. Glycolic acid concentrations as low as 0.12mM resulted in a ≥20% positive bias in lactate assay on the ABL 800 and a concentration of approximately 0.23mM resulted in>20% on the Roche Cobas c502 and Abbott i-STAT. A significant lactate gap is fo...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Darcy Rohr Mahesheema Ali Source Type: research

< em > Letter to the Editor: < /em > Morphoproteomics Confirms the Expression of Fatty Acid Synthase (FAS) in Reactive Alveolar Pneumocytes in a COVID-19 Victim: Biological and Therapeutic Implications
Ann Clin Lab Sci. 2021 Jul;51(4):587-588.NO ABSTRACTPMID:34452902 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Robert E Brown Source Type: research

< em > Letter to the Editor: < /em > Necrotizing Suppurative Dermatitis Caused by < em > Massilia oculi < /em > in an Immunocompromised Patient
Ann Clin Lab Sci. 2021 Jul;51(4):589-591.NO ABSTRACTPMID:34452903 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Jin-Hong Kim Yangsoon Lee Source Type: research

Clinical Performance of a Gene-Based Machine Learning Classifier in Assessing Risk of Developing OUD in Subjects Taking Oral Opioids: A Prospective Observational Study
CONCLUSION: This study demonstrates an ML classifier may provide additional objective information regarding a patient's risk of developing OUD. This information may enable subjects and healthcare providers to make more informed decisions when considering the use of oral opioids.PMID:34452883 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Keri Donaldson David Cardamone Michael Genovese Joseph Garbely Laurence Demers Source Type: research

A Brief History, the Progress in the Variants of Therapies against Metastatic Neoplasms, and the Role of Pathologists
Ann Clin Lab Sci. 2021 Jul;51(4):461-469.ABSTRACTChemotherapy originated in the early 1960s. The initial chemotherapeutic agents focused on blocking metabolic pathways and found substantial success in certain types of tumors, but they are generally considered toxic to all normal and tumor cells, and they have significant side effects. As more scientific studies began to identify many new, specific targets and mutations, along with a multitude of growth pathways in tumor cells, new agents targeting cell growth pathways began to emerge in the late 1990s and early 2000s. In 2003, a method called morphoproteomics was developed...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Kevin J Zhang Zhenhong Qu Ping L Zhang Robert E Brown Source Type: research

Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1
This study was conducted to explore the effects of Ese-3 on clinical prognosis in skin cancer and the functions of HaCaT cells.MATERIALS AND METHODS: Gene expression and clinical data were collected from The Cancer Genome Atlas (TCGA), The Genotype-Tissue Expression (GTEx), and three GSE datasets (GSE15605, GSE46517, and GSE114445). Comparison of data between groups was performed by Student's t-test and chi square test. Survival analysis was performed using log-rank test. Univariate and multivariate analyses were performed using Cox proportional hazards models. Enrichment analysis was used to predict Ese-3 related function...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Chao Zhang Junqiang Li Yongdong Guo Ronglin Wang Lei Hua Dongxue Gan Liaoliao Zhu Peixiang Ma Jing Yang Hong Li Shanshan Li Yang Song Haichuan Su Source Type: research

Down-Regulation of HBXIP Inhibits Non-Small Cell Lung Cancer Growth and Enhances the Anti-Tumor Immunity of Mice by Reducing NRP-1
CONCLUSION: Down-regulation of HBXIP reduced Lin28B-mediated NRP-1 to suppress NSCLC cell growth and enhance anti-tumor immunity.PMID:34452886 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lulu Wang Mao Sun Xing Lin Yongyang Lei Zhe Yin Wei Zhou Source Type: research

MiR-643 Functions as a Potential Tumor Suppressor in Gastric Cancer by Inhibiting Cell Proliferation and Invasion < em > via < /em > Targeting TXNDC9
CONCLUSION: miR-643 functions as a potential tumor suppressor in gastric cancer by inhibiting cell viability, colony formation, migration, and invasion via targeting TXNDC9, which provides a novel target for the diagnostic treatment of gastric cancer.PMID:34452887 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Yingxin Wu Huaping Ye Bo Peng Hongmei Jiang Qian Tang Yanjun Liu Juanli Xi Silu Chen Source Type: research

N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF- α Expressions
Ann Clin Lab Sci. 2021 Jul;51(4):503-511.ABSTRACTOBJECTIVE: To compare the e!cacy and functional outcomes of dl-3-n-Butylphthalide (NBP) and human urinary kallidinogenase (HUK) on ischemic stroke patients and to determine their effects on serum tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF).METHODS: A prospective study was conducted on 57 ischemic stroke patients. Functional outcomes were assessed by the National Institute Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the activities of daily living score (ADL), whereas TNF-α and VEGF expressions were measur...
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Yijing Guo Idriss Ali Abdoulaye Fei Liu Jiamin Wang Xiuxiu Tian Dafan Yu Kai Le Source Type: research

Association of IL28 B and IL10 Polymorphism with HCV Infection and Direct Antiviral Treatment
This study's findings indicate an independent association of SVR with high basal viral load (P=0.005) and an HCV genotype other than 3 (P=0.001). Patients with viral load log10>6.5 IU/mL required more days to reach an undetectable viral RNA load. The results of the genetic analysis showed a significant association of rs8103142 genotype CC (P
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Kashaf Junaid Hidayat Rasool Ata Ul Mustafa Hasan Ejaz Abdullah Alsrhani Humaira Yasmeen Sonia Younas Abualgasim Elgaili Abdalla Khalid Omer Abdalla Abosalif Sanaa Samir Mohamed Hamam Source Type: research

Fractionated Irradiation Enhances Invasion and Migration by Inducing Epithelial-Mesenchymal Transition and Stemness-Like Properties in A549 Cells
CONCLUSION: Fractionated irradiation could promote epithelial-mesenchymal transition and enhance the migration, invasion, and stemness-like properties in A549 cells, elucidating the possible radioresistance mechanisms of the cancer cells.PMID:34452890 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Lisheng Liu Ming Shang Xingguo Song Cong Zhang Wei Guo Source Type: research

Interleukin 2 Ameliorates Autoimmune Neuroinflammation by Modulating the Balance of T Helper 17 Cells and Regulatory T Cells in Mouse
CONCLUSION: Low-dose IL-2 is a potential therapeutic strategy for EAE and MS.PMID:34452891 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Jiannan Li Zhan Zhang Shuang Du Qi Guo Source Type: research

Pandemic-Associated Trends in Measurement of HbA1c in Children with Diabetes Mellitus and Validation of Dried Blood Spot as an Alternative Sample Matrix
CONCLUSION: DBS measurement of HbA1c presents a viable alternative to routine in-person laboratory monitoring of DM.PMID:34452892 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Emily R Garnett Brandy Recio Joanna Jung Estella Tam Sridevi Devaraj Source Type: research

Comparison of < em > Mycoplasma pneumoniae < /em > IgM and IgE Antibody Levels in Asthmatic and Non-Asthmatic Adults
CONCLUSION: IgM M. pneumoniae Abs may play an important role in non-asthma and persist for months after acute infection. IgE M. pneumoniae Abs may play a less important role in both groups.PMID:34452893 (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - August 28, 2021 Category: Laboratory Medicine Authors: Tamar A Smith-Norowitz Jeffrey Loeffler Yvonne Huang Yitzchok M Norowitz Rauno Joks Stephan Kohlhoff Source Type: research