Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice

Conclusions:
These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937

Received: 21 March 2017
Revised: 30 August 2017
Accepted: 05 September 2017
Published: 16 October 2017
Address correspondence to G.E. Crawford, Duke University Box 3382 Medical Center, Durham, NC 27710 USA. Telephone: [phone]. Email: [e-mail]; I. Rusyn, Texas A&M University, 4458 TAMU, College Station, TX 77843 USA. Telephone: [phone]. Email: [e-mail]; T. S. Furey, University of North Carolina, 5022 GMB Chapel Hill, NC 27514 USA. Telephone: [phone]. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP1937).
*These authors contributed equally to this work.
G. Chappell is currently employed by ToxStrategies, Inc., a scientific consulting firm. G. Chappell received no funding from ToxStrategies nor from any of its clients for this project, nor was ToxStrategies or any of its clients involved in the...

Source: EHP Research - October 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research