Does Zika Virus Cause Microcephaly – Applying the Bradford Hill Viewpoints

This study included more recent evidence compared to the previous one. The Bradford-Hill Viewpoints are used in public health to determine causation of diseases.11 Systematic application of the viewpoints can assist with analysing a possible causal relationship. Additional studies to assess the risk of microcephaly in affected pregnant mothers are ongoing.12 In this study we applied the Bradford-Hill viewpoints to investigate the association between Zika virus and Microcephaly. Method Using the Bradford Hills nine viewpoints we analysed data from a 2013 outbreak in French Polynesia and the 2015 Brazilian outbreak to establish a causal link between Zika virus and microcephaly. We searched major databases including PubMed, Medline and Embase from 2000 onwards using search words, such as Zika virus, Microcephaly and Flavivirus. We also searched news reports and grey literature for information on the outbreaks. We examined historical studies and previous data and also we compared historical rates of microcephaly prior to the Zika virus outbreak. Available data and studies were used to determine whether each of the nine Bradford Hill viewpoints were fulfilled. For strength of association, we sought studies which calculated measures of association for Zika virus and microcephaly. Where the calculation was not done, but suitable data available, we calculated a measure of association. We utilised data from a prospective cohort study conducted in Brazil “Zika virus infection ...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research

Related Links:

Passive measles immunity waned quickly, and most infants were no longer protected from measles by age 3 months, a study found; US experts say the age of vaccination should remain the same.Medscape Medical News
Source: Medscape Pulmonary Medicine Headlines - Category: Respiratory Medicine Tags: Infectious Diseases News Source Type: news
Journal of Medicinal Food, Ahead of Print.
Source: Journal of Medicinal Food - Category: Nutrition Authors: Source Type: research
Authors: Afsharpooyan S, Mohammadian T Abstract Helicobacter pylori infection occurs throughout the world between countries and races. A seroprevalence study of H. pylori infection in the occurrence of atherosclerosis (ASc) has been considered to be the main cause of cardiovascular diseases (CVDs) in part of Iran. From 600 volunteers, 97 serum samples were selected and tested for the presence of H. pylori infection. Positive and negative H. pylori infection samples were then selected for Chlamydia pneumonia and cytomegalovirus infection. Their serum levels for high-sensitive C-reactive protein (hs-CRP) and IL-6 tit...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Public health officials are investigating an E. coli outbreak that has infected at least 17 people in eight states, the US Centers for Disease Control and Prevention announced Wednesday.
Source: - Health - Category: Consumer Health News Source Type: news
Artificial intelligence is already widely entrenched in healthcare industry, so the question should not be, "Will AI happen or not?" said David Houlding, CISSP, CIPP, principal healthcare lead, at Microsoft, in an interview with MD+DI. “It's very much 'What tasks will AI help with, and what will it do and what will it not do?’ ” he continued. “I think we're still learning some of that, but it's largely a proven technology, not just for healthcare providers but for payers, for pharmaceuticals, for life sciencesâ&#...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
CONCLUSIONS The nude mouse orthotopic liver transplantation model of human HCC was shown to be a reliable model that has the potential for future research on the pathogenesis and progression of HCC and studies on drug development. PMID: 31736477 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Marques B, Couto J, Lemos MC, Rodrigues F Abstract Juxtaglomerular tumours are rare causes of secondary hypertension. They typically present with difficult-to-manage hypertension, hypokalemia, hyperreninemia and secondary hyperaldosteronism. The authors describe a clinical case of a 45 years old female patient, with personal history of difficult-to-manage hypertension and hypokalemia since age 35, medicated with four types of anti-hypertensive agents. An analytical study was performed, which revealed secondary hyperaldosteronism [aldosterone 44.3 ng/dL (4 - 28 ng/dL), renin> 1000 mIU/mL (4.4 - 46.2 mIU/...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Re: Musings on malaria morbidity and mortality after the new Mosquirix® vaccine. Ghana Med J. 2019 Sep;53(3):252-253 Authors: Asante KP, Malm K, Darko DM, Koram KA PMID: 31741498 [PubMed - in process]
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
Researchers at San Diego State University are developing a glassy carbon electrode...Read more on AuntMinnie.comRelated Reading: MEG helmet enables 3D functional brain imaging in kids 7T MRI opens door to detailed brain images 3T MRI feasible for deep brain stimulation patients Stretchable MRI coils on the horizon for MSK imaging Novel MRI scanner fits extremity imaging like a glove
Source: Headlines - Category: Radiology Source Type: news
Employing multiple artificial intelligence (AI) algorithms to attack a task...Read more on AuntMinnie.comRelated Reading: Practical Considerations of AI: Part 6 -- Ready, fire, aim Deep-learning algorithm bolsters lung cancer detection AI needs robust clinical evaluation in healthcare Deep-learning model characterizes PET/CT findings Can AI find brain hemorrhage as well as radiologists?
Source: Headlines - Category: Radiology Source Type: news
More News: African Health | AIDS Vaccine | Alcoholism | American Health | Amniocentesis | Autoimmune Disease | Babies | Brain | Chemistry | Cytomegalovirus | Databases & Libraries | Dengue Fever | Encephalitis | Environmental Health | Epidemics | Epidemiology | Erythema Infectiosum | Genetics | Girls | Hemorrhagic Stroke | Herpes | History of Medicine | HIV AIDS | Hospitals | International Medicine & Public Health | Men | Molecular Biology | Neurology | Outbreaks | Panama Health | Parvovirus | PET Scan | Pregnancy | Rubella | Rubella Vaccine | Stem Cell Therapy | Stem Cells | Study | Toxicology | Ultrasound | Vaccines | Veterinary Vaccinations | West Nile Virus | Women | Zika Virus