Can α-synuclein oligomers in skin biopsies predict the worsening of cognition in Parkinson’s disease? A single-center longitudinal cohort study
Background: Proximity ligation assay (PLA) has been employed to detect α-synuclein oligomers within synaptic terminals of autonomic fibers in skin biopsies from Parkinson’s disease (PD) patients. Whether this biomarker can track the progression of PD features is still unknown. We investigated whether the PLA score can predict the future worsening of cognitive functi on in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Contaldi, S. Mazzetti, M. Basellini, A. Colombo, V. Cereda, V. Ferri, I.U. Isaias, D. Calandrella, G. Cappelletti, G. Pezzoli Source Type: research
Let us not conflate burn risk and race onto patients with atopic dermatitis
In this issue of the Annals of Allergy, Asthma& Immunology, Alexis et al1 evaluated the efficacy and safety of abrocitinib by race, ethnicity, and Fitzpatrick skin types (FST). This analysis included pooled data from 945 patients older than 12 years who received abrocitinib 200 mg, abrocitinib 100 mg, or placebo from 3 double-blind placebo-controlled atopic dermatitis (AD) trials.1 Race and ethnicity were self-reported. Only data from White (n = 628), Asian (n = 204), and Black (n = 83) patients were analyzed because of low numbers of other racial subgroups, including multiracial patients and those who did not self-report ...
Source: Annals of Allergy, Asthma and Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Kanwaljit K. Brar Tags: Editorial Source Type: research
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
This study could possibly lead to new psoriasis treatments.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. (Source: Experimental and Molecular Medicine)
Source: Experimental and Molecular Medicine - May 1, 2024 Category: Molecular Biology Authors: Hee Joo Kim Jinsun Jang Kunhee Na Eun-Hui Lee Hyeon-Jung Gu Yoon Hee Lim Seul-A Joo Seung Eun Baek Joo-Young Roh Han-Joo Maeng Yun Hak Kim Young-Jae Lee Byung-Chul Oh YunJae Jung Source Type: research
A case report of Hyper ‐IgD syndrome in a 5‐year‐old girl with recurrent fever, skin rash, and arthralgia; novel MVK mutation (C.298G > A)
This report highlights the broad clinical phenotype of MVK and the need for increased awareness among healthcare professionals regarding its clinical presentation and management. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 30, 2024 Category: General Medicine Authors: Pooneh Tabibi,
Reza Shiari,
Shabnam Hajiani Ghotb Abadi Tags: CASE REPORT Source Type: research
A Multifunctional Herb ‐Derived Glycopeptide Hydrogel for Chronic Wound Healing
This research aimed to build a herb-derived versatile glycopeptide hydrogel as a promising dressing to promote chronic wound repair. AbstractChronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus-responsive glycopeptide hydrogel constructed by oxidizedBletilla striata polysaccharide (OBSP), gallic acid-grafted ε-Polylysine (PLY-GA), and pae...
Source: Small - April 30, 2024 Category: Nanotechnology Authors: Xinyi Zhang,
Ye Wu,
Heng Gong,
Yan Xiong,
Yu Chen,
Lin Li,
Biao Zhi,
Saiqun Lv,
Tao Peng,
Hui Zhang Tags: Research Article Source Type: research
Promoting clinical research in community-based practice: Threats and opportunities
Ann Dermatol Venereol. 2024 Apr 29;151(2):103272. doi: 10.1016/j.annder.2024.103272. Online ahead of print.NO ABSTRACTPMID:38688174 | DOI:10.1016/j.annder.2024.103272 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 30, 2024 Category: Dermatology Authors: F Poizeau A Maruani D Staumont-Sall é N Jouan S Ly M Schollhammer M Reverte C Dibao-Dina T-A Duong B Matard D Penso-Assathiany A Dupuy M Carriot J-F Se ï F Corgibet B Guillot S Barbarot S Leducq A Bertolotti J Tannous G Chaby D Jullien E P épin G Qu é Source Type: research
Influence of type of vehicle on dermal penetration efficacy of hydrophilic, amphiphilic, lipophilic model drugs
Eur J Pharm Biopharm. 2024 Apr 27:114305. doi: 10.1016/j.ejpb.2024.114305. Online ahead of print.ABSTRACTThe influence of the vehicle on the dermal penetration efficacy of three different active ingredient (AI) surrogates (hydrophilic, amphiphilic, lipophilic model drugs), that were incorporated into these vehicles, was investigated with the ex vivo porcine ear model, which allowed to assess time and space resolved dermal penetration profiles of the AI. Fifteen different vehicles, including classical vehicles (hydrogel, oleogel, o/w cream, w/o ointment, amphiphilic cream) and innovative vehicles were included into the stud...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 30, 2024 Category: Drugs & Pharmacology Authors: Vasudha Kaushik Wolfgang Schatton Cornelia M Keck Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Clinical Breast Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
Factors Influencing Iatrogenic Skin Injury in Neonates and Nursing Strategies
CONCLUSION: Length of stay, orotracheal intubation use, and gastric tube use are independent risk factors for iatrogenic skin injury in neonates. Hospital stays and unnecessary use of orotracheal intubation and gastric tube should be reduced in future clinical management. Attention should be paid to strengthening skin observation and care, keeping skin dry and clean, and preventing iatrogenic skin injury.PMID:38687850 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Huifang Deng Chunhua Li Nuo Yu Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Clinical Genitourinary Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
Concomitant Moderate to Severe Cutaneous Lesions Have Marked Impact on Quality of Life in Patients with Active Systemic Lupus Erythematosus: A Cross-Sectional Insight from Two Phase 3 Randomised Clinical Trials in Adults
Br J Dermatol. 2024 Apr 30:ljae183. doi: 10.1093/bjd/ljae183. Online ahead of print.NO ABSTRACTPMID:38687872 | DOI:10.1093/bjd/ljae183 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 30, 2024 Category: Dermatology Authors: Mischa J Mallbris Bochao Jia Youna Zhao J Michelle Kahlenberg Johann E Gudjonsson Source Type: research
In vitro study of cold atmospheric plasma-activated liquids inhibits malignant melanoma by affecting macrophage polarization through the ROS/JAK2/STAT1 pathway
This study illustrates that PAL therapy is an effective tumor immunotherapy and expands the scope of tumor immunotherapy. Furthermore, these findings establish a theoretical foundation for potential clinical applications of PAL.PMID:38688171 | DOI:10.1016/j.biopha.2024.116657 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Shiyun Zhou Xingyu Yang Miaomiao Ren Yongshuang Qi Yiwen Mao Chunjun Yang Source Type: research
Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
In conclusion, these findings declare that VV polyphenolic fractions, particularly VVF1, could be promising safe anti-HCC agents.PMID:38688169 | DOI:10.1016/j.biopha.2024.116638 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Nadia Z Shaban Walaa A Hegazy Marwa M Abu-Serie Iman M Talaat Olfat M Awad Noha H Habashy Source Type: research
Age group-specific changes in keratinocyte cancer treatment rates in Australia, 2012- 2021: a retrospective cohort study based on MBS claims data
CONCLUSIONS: Rates of MBS-subsidised treatment for keratinocyte cancers increased during 2012-2019, but BCC/SCC treatment rates declined among younger Australians, who have probably been exposed to less sunlight than earlier generations because of public health interventions and population-wide lifestyle changes related to technology use.PMID:38685827 | DOI:10.5694/mja2.52293 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - April 30, 2024 Category: General Medicine Authors: Catherine M Olsen Nirmala Pandeya Rachel E Neale David C Whiteman Source Type: research
Wound Healing Activity of Topical Herbal Gels Containing Barringtonia acutangula Fruit Extract: In silico and In vivo Studies
Chem Biodivers. 2024 Apr 30:e202400147. doi: 10.1002/cbdv.202400147. Online ahead of print.ABSTRACTThe current study describes the efficacy of B. acutangula fruit extract in wound healing via incorporation within topical gels. B. acutangula fruit extract was produced by solvent extraction method. The bioactive extract was incorporated within Carbopol 940-based topical gels, which were applied topically over the excision and incision wounds. The change in healing process was observed till 20 days. The percentages of closure of excision wound area were 92.89% and 93.43%, when treated with topical herbal gels containing B. ac...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Kumari Priyanka Rudra Narayan Sahoo Ashirbad Nanda Satish Kanhar Chandan Das Abhijit Sahu Pradeep Kumar Naik Amit Kumar Nayak Source Type: research
