A new mechanism in negative pressure wound therapy: interleukin-17 alters chromatin accessibility profiling
In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting re-epithelialization, extracellular matrix (ECM) synthesis and prol...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Shuao Xiao Wenxuan Wang Congying Zhao Pan Ren Liwei Dong Hao Zhang Fuxin Ma Xueyong Li Yongqian Bian Source Type: research
A new mechanism in negative pressure wound therapy: interleukin-17 alters chromatin accessibility profiling
In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting re-epithelialization, extracellular matrix (ECM) synthesis and prol...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Shuao Xiao Wenxuan Wang Congying Zhao Pan Ren Liwei Dong Hao Zhang Fuxin Ma Xueyong Li Yongqian Bian Source Type: research
Clinical course and disease burden of patients with generalized pustular psoriasis in Portugal: a multicenter retrospective cohort study
CONCLUSIONS: Our study demonstrates that GPP is a chronic, debilitating condition associated with systemic involvement, frequent flares, and hospitalizations, despite receiving multiple systemic treatments. Improved disease awareness and new treatments are needed to improve patient care and decrease the burden of the disease.PMID:38684228 | DOI:10.1080/09546634.2024.2345728 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 29, 2024 Category: Dermatology Authors: Tiago Torres Joana Antunes Ana Brasileiro Jo ão Alves Diana Bernardo Jos é Ramos Diogo Sousa Cristina Castro Ana Gusm ão Palmeiro Andr é Aparício Martins Joana Fazendeiro Matos B árbara Vieira Granja Pedro Ponte Gabriela Marques Pinto Paula Quirino Source Type: research
Statement of retraction: evidence-based clinical practice guidelines for the management of psoriasis: systematic review, critical appraisal, and quality assessment with the AGREE II instrument
J Dermatolog Treat. 2024 Dec;35(1):2334685. doi: 10.1080/09546634.2024.2334685. Epub 2024 Apr 29.NO ABSTRACTPMID:38684214 | DOI:10.1080/09546634.2024.2334685 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 29, 2024 Category: Dermatology Source Type: research
Unexpected discovery of renal mass in a patient with granulomatosis with polyangiitis: accidental or inevitable?
Clin Exp Rheumatol. 2024 Apr;42(4):905-913. doi: 10.55563/clinexprheumatol/ql3zzz. Epub 2024 Apr 8.ABSTRACTGranulomatosis with polyangiitis (GPA) is an uncommon disorder that mainly involves the upper and lower respiratory tract and kidney, presenting as sinusitis, saddle nose, otitis media, pulmonary nodule and cavity, rapidly progressive glomerulonephritis. It also affects skin, eye, heart, joint and nervous system. Renal involvement in GPA is commonly manifested as necrotising glomerulonephritis, while renal mass is very rare. We herein present two hospitalised cases with fever, pulmonary cavity and renal mass. Clinical...
Source: Clinical and Experimental Rheumatology - April 29, 2024 Category: Rheumatology Authors: Kunyu Zheng Junyan Qian Nan Jiang Jingmin Zhou Li Wang Fengchun Zhang Source Type: research
The first molecular investigation of Besnoitia besnoiti infections among cattle in Mosul, Iraq
CONCLUSIONS: Findings from this study will serve as baseline data in the epidemiology, prevention, and control of the protozoan among cattle in Iraq.PMID:38683464 | DOI:10.1007/s11033-024-09377-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Wasan Amjad Alobaidii Donea Abdulrazak Abdullah Yahya Natiq Mohammed Alkatab Shahad Abbas Ali Shola David Ola-Fadunsin Fufa Ido Gimba Source Type: research
Silymarin inhibits dermal gelatinolytic activity and reduces cutaneous inflammation
Nat Prod Res. 2024 Apr 29:1-12. doi: 10.1080/14786419.2024.2347452. Online ahead of print.ABSTRACTMilk thistle (Silybum marianum) is well-known for its antioxidant activity due to the presence of silymarin. Albeit some studies show a potential for skin inflammation, its activity against dermal MMP-9 and MMP-2 remains to be studied. Silymarin isolated from an S. marianum herbal extract was tested for gelatinase inhibition in the presence of isolated MMP-9 and in dermal adenocarcinome HaCaT cells. Silymarin was then further tested in vivo, using a cutaneous inflammation mice model mediated by reactive oxygen species. Silymar...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Joana Mota Catarina Faria-Silva Ana Resendes Maria Isabel Santos Manuela Colla Carvalheiro Ana Lima Sandra Sim ões Source Type: research
Use of dynamic tissue system adhesive skin closure device and multi-tissue platform porcine xenograft to achieve primary closure after wide local excision of a melanoma
CONCLUSION: The results of this patient's case indicate that DTS adhesive skin closure device should be considered as an additional option for the closure of large defects following wide local excision in the management of melanoma.PMID:38684122 (Source: Wounds)
Source: Wounds - April 29, 2024 Category: General Medicine Authors: Jad F Zeitouni Reagan Collins Patricia Arledge Yana Puckett Catherine F Ronaghan Source Type: research
Cutaneous Crohn disease presenting as "knife-edged" ulcers: a case report
CONCLUSIONS: This case supports the inclusion of CCD in the differential diagnosis in patients with knife-edged granulomatous skin lesions in intertriginous locations. This clinical condition may present in the setting of no or limited GI symptoms. The management of CCD and a proposed treatment algorithm are also presented.PMID:38684123 (Source: Wounds)
Source: Wounds - April 29, 2024 Category: General Medicine Authors: Melissa A Nickles Saman S Karimi Heidi Kurn Marylee Braniecki Anne Polick Itishree Trivedi Nadera Sweiss Igor A Altman Source Type: research
The Observatoire en Ville des Plaies ExSudatives (VIPES) study: insight into the patient characteristics, epidemiology, previous management, and features of wounds treated in the French community setting
CONCLUSIONS: The VIPES study highlights that wounds can be complex and that community care practices in France warrant improvement. Practical and up-to-date wound management recommendations are needed.PMID:38684125 (Source: Wounds)
Source: Wounds - April 29, 2024 Category: General Medicine Authors: Pascal Vasseur Nayla Ayoub Christine Juhel Romain Schueller Adoraci ón Pegalajar-Jurado Florence Armstrong Source Type: research
Novel foam dressing with through holes and negative pressure wound therapy with instillation and dwell time: a retrospective cohort study
CONCLUSION: ROCF-CC dressings were a useful tool in assisting wound bed preparation and reducing time to skin graft closure in this series of complex VLUs.PMID:38684120 (Source: Wounds)
Source: Wounds - April 29, 2024 Category: General Medicine Authors: Carlotta Scarpa Martina Grigatti Sandro Rizzato Alberto Crema Vincenzo Vindigni Franco Bassetto Source Type: research
Lactic Acid Chemical Peeling in Skin Disorders
Clin Cosmet Investig Dermatol. 2024 Apr 23;17:901-909. doi: 10.2147/CCID.S455700. eCollection 2024.ABSTRACTLactic acid is the most widely occurring natural organic acid in nature. It not only exhibits mild and safe properties but also possesses multiple physiological activities, such as antibacterial effects, immune regulation, and promotion of wound healing, making it one of the most popular chemical peeling agents. Chemical peels are commonly used in the field of aesthetic dermatology as a non-invasive therapeutic approach. This research aims to provide valuable references for clinical dermatologists by summarizing the c...
Source: Clinical, Cosmetic and Investigational Dermatology - April 29, 2024 Category: Dermatology Authors: Xiaoyue Feng Jianli Shang Zhengping Gu Xingyi Luo Yong Chen Youting Liu Source Type: research
Managing Severe Postburn Wrist Flexion Contracture by Proximal Row Carpectomy and Abdominal Interpolation Flap
Conclusion Proximal row carpectomy shortens the length of the wrist, resurfaces the wrist joint, and provides a release in tendons and other soft tissues. Together with soft tissue transfer, this technique can be used for severe wrist flexion contractures.PMID:38681246 | PMC:PMC11046275 | DOI:10.1177/22925503221107213 (Source: Hand Surgery)
Source: Hand Surgery - April 29, 2024 Category: Surgery Authors: Berrak Karatan Kamil Yamak Source Type: research
Skin reactions associated with glucose monitoring devices
Ir Med J. 2024 Apr 25;117(4):942.NO ABSTRACTPMID:38682671 (Source: Ir Med J)
Source: Ir Med J - April 29, 2024 Category: General Medicine Authors: P Finnegan E Porter J Bourke Source Type: research
Human herpesvirus type 6 in patients with systemic lupus erythematosus
CONCLUSION: Although patients with SLE had a higher prevalence of HHV-6 compared with healthy people, there is no strong link between HHV-6 infection and SLE. Future research is necessary because this data does not support the hypothesis that human herpesvirus 6 plays a role in the pathogenesis of SLE.PMID:38682068 | PMC:PMC11055447 | DOI:10.18502/ijm.v16i1.14883 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Mohammad Shayestehpour Elnaz Vatani Batool Zamani Ahmad Piroozmand Shaghayegh Yazdani Kamal Esalatmanesh Zahrasadat Fateminasab Source Type: research
