Mismatch between the impact of disease perceived by patients and the state of clinical remission assessed by physicians in psoriatic arthritis.
CONCLUSIONS: We found a clear disagreement between the impact of illness perceived by the patient with PsA and clinical remission judged by physicians. Therefore, clinical and treatment decision-making in PsA should be based more on composite indexes (DAPSA) than on the perceptions of treating physicians. PMID: 31994477 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence of cranial involvement in a cohort of Italian patients with chronic non-bacterial osteomyelitis.
CONCLUSIONS: This is the first report of neurocranium involvement in a cohort of patients affected by CNO. In our cohort no patient showed significant signs attributable to cranial involvement. PMID: 31994478 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Performance of the 2016 ACR/EULAR Sj ögren's syndrome classification criteria in patients with secondary Sjögren's syndrome.
CONCLUSIONS: Our study provides further evidence that the 2016 ACR/EULAR criteria are applicable in the setting of secondary SS. PMID: 31994479 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Work participation and sick leave in women with systemic lupus erythematosus and matched controls during and after pregnancy.
Authors: Blomjous BS, Ter Wee MM, Abheiden CNH, Voskuyl AE, de Vries JIP, Bultink IEM PMID: 31994480 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

rs10865331 in 2p15 increases susceptibility to ankylosing spondylitis: a HuGE review and meta-analysis.
Authors: Zhang Z, Deng C, Ma X, Liu X Abstract OBJECTIVES: 2p15 polymorphisms have been reported to increase ankylosing spondylitis (AS) susceptibility in several studies; however, when it comes to whether and how much of this risk exists, the results are inconclusive. The aim of this study is to investigate the correlation between rs10865331 in 2p15 and the risk of AS. METHODS: We conducted a HuGE review and meta-analysis of studies published through September 2019. Studies were identified in PubMed, Scopus, HuGE Navigator, Embase, and Web of Science databases. Odds ratios (ORs) and 95% confidence intervals (C...
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tocilizumab in a patient with newly diagnosed rheumatoid arthritis secondary to checkpoint inhibitor therapy.
Authors: Pirker I, Rubbert-Roth A, von Kempis J, Fehr M, Neumann T PMID: 31994482 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Takayasu's arteritis with familial Mediterranean fever.
Authors: Limon M, Tezcan D, Gülcemal S, Yilmaz S, Nayman A PMID: 31994483 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Salivary gland ultrasound integrated with 2016 ACR/EULAR classification criteria improves the diagnosis of primary Sj ögren's syndrome.
Salivary gland ultrasound integrated with 2016 ACR/EULAR classification criteria improves the diagnosis of primary Sjögren's syndrome. Clin Exp Rheumatol. 2020 Jan 27; Authors: Geng Y, Li B, Deng X, Ji L, Zhang X, Zhang Z Abstract OBJECTIVES: To evaluate the utility of salivary gland ultrasound (SGUS) in the diagnosis of primary Sjögren's syndrome (pSS) singly or integrated with 2016 ACR/EULAR classification criteria. METHODS: Patients with suspected pSS were enrolled in the study. SGUS semi-quantitative scoring was used to assess salivary gland. Clinical characteristics were recorded, in...
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Distribution of the components of the MDA response among patients with psoriatic arthritis with and without an acceptable symptomatic state.
Authors: Queiro R, Pardo E, Charca L PMID: 31994485 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Relationship between lysosomal-associated membrane protein-2 and anti-phosphatidylserine/prothrombin complex antibody in the pathogenesis of cutaneous vasculitis.
CONCLUSIONS: Anti-PS/PT and anti-LAMP-2 antibodies are responsible for independent effector mechanisms in the rats given intravenous injection of cell-free histones. We considered that undetermined factors other than cell-free histones could be required for the induction of cutaneous vasculitis by anti-PS/PT and anti-LAMP-2 antibodies. PMID: 31994486 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Surfactant protein D is associated with 3-month mortality of anti-MDA5 antibody-interstitial lung disease.
Authors: Lyu W, Zhou Y, Zhuang Y, Liu Y, Cao M, Xin X, Wu H, Wang J, Meng F, Cai H, Dai J Abstract OBJECTIVES: To investigate the associations between serum levels of matrix metalloproteinase 7 (MMP7), surfactant protein D (SPD), interleukin 18 (IL-18) and chemokine ligand 18 (CCL18) with dermatomyositis and polymyositis-associated interstitial lung disease (DM/PM-ILD) and evaluate their prognostic values in the disease. METHODS: Seventy-eight patients with multiple disciplinary team diagnosis of DM/PM-ILD were enrolled and classified as anti-melanoma differentiation-associated protein 5 antibody (MDA5)-ILD, an...
Source: Clinical and Experimental Rheumatology - January 30, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Safety of surgery in patients with rheumatoid arthritis treated with tocilizumab: data from the French (REGistry -RoAcTEmra) Regate registry.
CONCLUSIONS: In RA patients treated with TCZ in perfusion, the rate of surgical complications was low: 8.6%. The median time between surgery and last infusion was relatively short according to half-life of TCZ but did not influence the rate of postoperative complications. PMID: 31969215 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Differential performance of nailfold video capillaroscopic parameteres in the diagnosis and prognosis of systemic sclerosis.
CONCLUSIONS: Dilatation score performs best of all semi-quantitative NVC parameters in diagnosing SSc. In addition, our study confirms earlier reports that worse capillaroscopy pattern at baseline correlates with higher likelihood for adverse prognosis. PMID: 31969216 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Acute rheumatic fever prophylaxis in high-income countries: clinical observations from an Italian multicentre, retrospective study.
CONCLUSIONS: Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm our data in a larger population. PMID: 31969217 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility.
CONCLUSIONS: TLR3 is overexpressed in SLE skin lesions and amplifies apoptotic and inflammatory responses to UV-irradiation in antigen-presenting cells in vitro. However, TLR3 SNPs do not impact susceptibility to the development of the disease. PMID: 31969218 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Characteristics and risk factors of pulmonary embolism in patients with systemic lupus erythematosus: a case control study.
This study was conducted to explore the characteristics and risk factors of PE in SLE patients. METHODS: Using the Hospital Information System of Peking Union Medical College Hospital, we conducted a case-control study in SLE patients complicated with PE from January 2012 to December 2018 as the case group, and age-, sex-, and entry-time-matched SLE patients without PE at the ratio of 1:3 as the control group. We explored the risk factors of PE in SLE patients using multivariate logistic regression analyses. RESULTS: A total of 90 cases confirmed with PE from 6994 hospitalised SLE patients were identified and 257 m...
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rheumatoid factor-producing CD21low anergic clonal B-cells in essential mixed cryoglobulinaemia: a model for autoantigen-driven pathogenesis of infectious and non-infectious cryoglobulinaemias.
CONCLUSIONS: Our findings suggest a common pathogenetic mechanism in EMC, HCV-MC and primary Sjögren's syndrome, consisting of autoantigen-driven clonal expansion and exhaustion of selected RF-producing B-cells. The more massive clonal expansion in HCV-MC may be due to co-stimulatory signals provided by the virus. PMID: 31969220 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Contribution of Th2-like Treg cells to the pathogenesis of Takayasu's arteritis.
Authors: Gao N, Cui W, Zhao LM, Li TT, Zhang JH, Pan LL Abstract OBJECTIVES: Takayasu's arteritis (TAK) involves inflammatory vasculitis of large vessels and mainly affects the aorta and its major branches. Abnormal immunity may play a vital role in TAK pathogenesis. Regulatory T cells (Treg cells) are important for peripheral tolerance, but under certain conditions Treg cells can differentiate into Th-like cells that have lost immune suppressive function and promote the development of autoimmune diseases. The role of Th-like Treg cells in TAK is unclear and this study aims to investigate the function of Th-like Tr...
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Survival of patient with giant cell arteritis: a controversial issue.
CONCLUSIONS: Epidemiologic studies varied considerably in the reported outcomes of GCA patients: some found that the overall survival was similar to that of the general population while others reported increased mortality in GCA or in subgroups of GCA patients. PMID: 31969222 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serodiscordant patients with systemic sclerosis: when antibody does not correspond to skin involvement.
CONCLUSIONS: In our cohort, the prevalence of serodiscordant SSc patients was low. They differed from their counterparts in some clinical manifestations. The management of patients with SSc should be guided by both serology and cutaneous subtype. PMID: 31969223 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Takayasu's arteritis: associated inflammatory diseases.
CONCLUSIONS: TAK does co-occur with IBD, AS and less frequently with BS in about 1/5 of the patients, at least in a hospital setting. There is no clear temporal pattern. The high prevalence of inflammatory back pain in the dorsal spine in TAK needs further scrutiny. PMID: 31969224 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comparative study between two European inception cohorts of patients with early systemic lupus erythematosus.
Authors: Prevete I, Espinosa G, Bellisai F, Bortoluzzi A, Conti F, Fredi M, Fonseca-Aizpuru EM, García de Viedma V, González-García A, González-León R, Iaccarino L, Iannone F, Marín-Ballvé A, Mitjavila F, Pallarés L, Piga M, Ríos-Garcés R, Suárez S, Tani C, Zanetti A, Ruiz-Irastorza G, Sebastiani GD, Gruppo di Studio SIR sul Lupus Eritematoso Sistemico di recente insorgenza-Early Lupus and Registro Español de pacientes con Lupus Eritematoso Sistémico (RELES), Autoimmune Diseases Study Group (GEAS) Abstract OBJECTIVES: To comp...
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Risk of non-Hodgkin's lymphoma and thyroid cancer in primary Sj ögren's syndrome measured using the Korean Health Insurance Claims Database.
CONCLUSIONS: Although pSS is associated with a higher risk of developing NHL, the risk of NHL appears to have decreased compared with that in previous studies. Our study suggests that the risk of NHL or thyroid cancer with SS is not higher than that reported in previous studies. PMID: 31969226 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum CXCL10 levels are associated with better responses to abatacept treatment of rheumatoid arthritis.
CONCLUSIONS: ABT treatment significantly affected IFN-γ and CXCL10 cytokine levels in vitro. In addition, serum CXCL10 levels were associated with better responses in ABT treatment. PMID: 31969227 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Biological DMARD efficacy in psoriatic arthritis: a systematic literature review and meta-analysis on articular, enthesitis, dactylitis, skin and functional outcomes.
CONCLUSIONS: All bDMARDs showed higher ACR20 response rates and better HAQ-DI mean reduction compared to placebo. This meta-analysis highlights the variability of bDMARD efficacy on ACR50/70, PASI75/90 and enthesitis or dactylitis response rates. Head-to-head studies are needed to draw definitive conclusions on potential efficacy-related differences between bDMARDs in PsA. PMID: 31969228 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Disease Activity in Psoriatic Arthritis Index and Psoriatic Arthritis Impact of Disease Questionnaire: correlation and sensitivity to change in a real clinical setting.
Authors: Pardo E, Charca L, Alonso S, Alperi M, Arboleya L, Queiro R Abstract OBJECTIVES: The performance of many outcome measures for psoriatic arthritis (PsA) is almost unknown in real clinical practice. Our objective was to study the correlation and sensitivity to change of the Disease Activity in Psoriatic Arthritis (DAPSA) index and the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire in a real practice setting. METHODS: This was a prospective, open, non-controlled study that included 60 consecutive patients with PsA treated with ustekinumab. Most had been previously treated with one or more bio...
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Recommendations in clinical practice guidelines on gout: systematic review and consistency analysis.
Authors: Yu Y, Wang D, Zhou Q, Wang C, Ma X, Gao Y, Song X, Xiao S, Wang Q, Zeng X, Estill J, Qian Z, Chen Y Abstract OBJECTIVES: To compare and analyse the recommendations from clinical practice guidelines (CPGs) on gout worldwide, examine the consistency across CPGs, and provide suggestions to develop and update gout guidelines. METHODS: We conducted systematic searches in MEDLINE, CBM, GIN, NICE, NGC, WHO, SIGN, DynaMed, UpToDate, and Best Practice databases, from their inception to August 2019 to identify and select CPGs related to gout. We used the search terms "gout", "hyperuricaemia" ...
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The potential role of leflunomide in inhibiting vascular fibrosis by down-regulating type-II macrophages in Takayasu's arteritis.
CONCLUSIONS: LEF could potentially reduce vascular fibrosis by down-regulating the number and function of M2, which, eventually, could alleviate inflammatory fibrosis of aortic lesions in TAK patients. PMID: 31969231 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comparable effects of traditional cardiovascular risk factors on subclinical atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis.
CONCLUSIONS: The influence of traditional cardiovascular risk factors on cIMT and carotid plaque is similar in RA and SLE. PMID: 31969232 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 25, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Mortality rate of patients with giant cell arteritis as isolated inflammation or fever of unknown origin, typo or sensational?
Authors: Gilutz H PMID: 31928588 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence of fibromyalgia and associated factors in Spain.
CONCLUSIONS: The prevalence of FM in adults in Spain barely changed between 2000 and 2016 and it is similar to that observed in Europe as a whole. PMID: 31928589 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Differentiation between neurosarcoidosis and primary central nervous system vasculitis based on demographic, cerebrospinal and imaging features.
CONCLUSIONS: These findings suggest that MRI can be an efficient tool in distinguishing PACNS from NS. A follow-up study with a larger sample size would be required to validate our results. PMID: 31928590 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Oropharyngeal swallowing functions are impaired in patients with scleroderma.
Authors: Eyigor S, Sezgin B, Kuntman BD, Karabulut G, Zihni Yargucu F, Ozturk K, Kirazli T PMID: 31928591 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Analysis of mortality in patients with giant cell arteritis presenting with isolated inflammation or fever of unknown origin.
Authors: de Boysson H, Aouba A PMID: 31928592 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tofacitinib for the treatment of refractory Takayasu's arteritis: description of 2 cases.
Authors: Palermo A, Marvisi C, Casali M, Pipitone N, Muratore F, Salvarani C PMID: 31928593 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Emotional regulation processes: influence on pain and disability in fibromyalgia patients.
CONCLUSIONS: FM patients need to be trained in strategies for regulating their emotions, in order to achieve a reduction in negative mood states, as well as their impact in pain and disability. PMID: 31928594 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 15, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Phenotypic variability including Beh çet's disease-like manifestations in DADA2 patients due to a homozygous c.973-2A > G splice site mutation.
CONCLUSIONS: We describe three families with the same homozygous splice site mutation in ADA2 and observed a novel combination of manifestations resembling Behçet's disease. This further expands the range of phenotypes caused by ADA2 mutations, although no complete genotype-phenotype association could be determined. Even without active disease, the risk of stroke should be addressed in making decisions regarding treatment of DADA2 patients. PMID: 31856934 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Oral ulcer activity assessment with the composite index according to different treatment modalities in Beh çet's syndrome: a multicentre study.
Oral ulcer activity assessment with the composite index according to different treatment modalities in Behçet's syndrome: a multicentre study. Clin Exp Rheumatol. 2019 Nov-Dec;37 Suppl 121(6):98-104 Authors: Mumcu G, Karacayli Ü, Yay M, Aksoy A, Taş MN, Armağan B, Sari A, Bozca BC, Tekgöz E, Karadağ DT, Badak SÖ, Tecer D, Bes C, Şahin A, Erken E, Cefle A, Çinar M, Yilmaz S, Alpsoy E, Şenel S, Bilge ŞY, Kaşifoğlu T, Karadağ Ö, Aksu K, Keser G, Alibaz-Öner F, Inanç N, Ergun T, Direskeneli H Abstract OBJECTIVES: The aim of this multicentre study was t...
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Circulating endothelial cells in Beh çet's disease: is there a relationship with vascular involvement?
CONCLUSIONS: CEC, EPC, aCEC and rCEC may have role in the assessment of vascular involvement in BD. Longitudinal studies would be needed to identify the utility of these cells for the follow up and risk stratification of BD patients with vascular involvement for recurrences or identify BD patients at risk of vascular involvement. PMID: 31856936 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Biosimilar infliximab for Beh çet's syndrome: a case series.
CONCLUSIONS: Our limited experience showed that bio-IFX may be a safe and effective alternative for patients with BS, refractory to conventional immunosuppressives. PMID: 31856937 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Outcome of invasive procedures for venous thrombosis in Beh çet's syndrome: case series and systematic literature review.
CONCLUSIONS: Endovascular and surgical interventions seemed to be unsuccessful because of recurrent infectious and vascular complications in 22 (53.6%) of 41 patients with venous thrombosis. The indication of these procedures is controversial. Their economic burden on the healthcare system must be considered. PMID: 31856938 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2019: Beh çet's syndrome.
One year in review 2019: Behçet's syndrome. Clin Exp Rheumatol. 2019 Nov-Dec;37 Suppl 121(6):3-17 Authors: Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V Abstract Several epidemiologic studies report on the prevalence of Behçet's syndrome (BS) and demographic and clinical findings in patients from different countries and ethnicities. Although these studies point out geographic differences in disease course, methodologic differences make it difficult to compare the results of these studies. Recent data suggest that neutrophil extracellular trap levels are elevated in patients with ...
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased frequency of obstructive sleep apnea syndrome in Beh çet's syndrome patients with superior vena cava syndrome.
Increased frequency of obstructive sleep apnea syndrome in Behçet's syndrome patients with superior vena cava syndrome. Clin Exp Rheumatol. 2019 Nov-Dec;37 Suppl 121(6):132-136 Authors: Gokturk A, Esatoglu SN, Atahan E, Hamuryudan V, Yazici H, Seyahi E Abstract OBJECTIVES: Superior vena cava syndrome (SVCS) is a medical emergency which can also be seen in Behçet's syndrome (BS). Having noted that BS patients with SVCS frequently complained of sleep disturbances, snoring and sleep apnea, suggesting obstructive sleep apnea (OSA), we formally surveyed the risk for OSA among BS patients. ...
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Induction of ocular Beh çet's disease remission after short-term treatment with infliximab: a case series of 11 patients with a follow-up from 4 to 16 years.
CONCLUSIONS: Successful short-term infliximab treatment combined with conventional immunosuppressives for BD-associated sight-threatening uveitis may lead to remission for many years thereafter. This observation may suggest that infliximab as a first-line therapy should be promptly administered to every patient with ocular BD for rapid remission of ocular inflammation and preservation of visual acuity. PMID: 31856941 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sixth-month remission as a predictor for twelve-month remission in polymyalgia rheumatica.
Authors: Birra D, Bosello SL, Peluso G, Zoli A Abstract OBJECTIVES: To investigate clinical and laboratory prognostic factors of remission after one year of follow-up in patients with polymyalgia rheumatica (PMR) treated with low-dose prednisone. METHODS: In this observational study, in a monocentric Italian Rheumatology Unit, we enrolled eighty-one consecutive PMR patients. Clinical and laboratory tests were performed every 3 months. Clinical remission was defined as the lack of symptoms, while laboratory remission was defined as erythrocyte sedimentation rate ≤40 mm/h and C-reactive protein (CRP) ≤0.5 m...
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between musculoskeletal ultrasonography and bone remodelling markers and its role in disease monitoring of gout and hyperuricaemia.
Authors: Zou Y, Fei Y, Gao H, Xie LF, Zhong YC, Yang QZ, Wang DL, Zhang XW Abstract OBJECTIVES: To evaluate associations between bone destruction markers and musculoskeletal ultrasonography (MU) findings in patients with gout and hyperuricaemia and clarify the role of MU in treatment responsiveness. METHODS: One-hundred and fifty patients with gout and 100 patients with hyperuricaemia were divided into five groups according to MU manifestations. Circulating Dickkopf-1 (DKK-1) and receptor activator of nuclear factor-κB ligand (RANKL) levels were measured. Thirty patients from the gout group and 10 from th...
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reply to: Bone marrow oedema on sacroiliac/spine MRI: is it really a sign of objective inflammation warranting treatment?
Authors: Baraliakos X, Anderson JK PMID: 31858959 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Consideration of coping strategies for patients suffering from systemic lupus erythematosus: reflection for a personalised practice of patient education.
CONCLUSIONS: Patients' knowledge is not the only parameter to consider for a personalised educational therapy: psychological parameters such as coping must also be considered to ensure the best possible quality of life. For educational therapy purposes, it is important not to group patients with the same coping style; heterogenous groups will enable patients to share their experiences and learn from the coping strategies of others. PMID: 31858960 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Fingerprinting of anti-alpha enolase antibodies in systemic sclerosis.
CONCLUSIONS: Anti-alpha enolase antibodies are very frequent in SSc but are not associated with clinical or serological features of the disease. Further studies on larger cohorts of patients are necessary to define their possible contribution in defining specific subsets of the disease. PMID: 31858961 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between autoantibody level and disease activity in rheumatoid arthritis is dependent on baseline inflammation.
Authors: Pongratz G, Frieser R, Brinks R, Schneider M, Hartung W, Fleck M, Ehrenstein B Abstract OBJECTIVES: It is still controversial whether autoantibody (AAb) serum levels have a value for response monitoring in rheumatoid arthritis (RA). Therefore, we retrospectively investigated a real-life outpatient RA cohort to determine which factors are associated with change in serum AAb levels and RA disease activity. The primary goal of the study was to determine predictors for changes in DAS28 and autoantibodies over time and identify traits of non-rituximab treated patients, which would define strong association of d...
Source: Clinical and Experimental Rheumatology - December 22, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research