Acute anterior uveitis in spondyloarthritis: a monocentric study of 301 patients.
CONCLUSIONS: Prevalence of uveitis in SpA seems to increase with disease duration and seems more likely to appear with HLA B27 positivity and heel pain. Anti-TNF monoclonal antibodies seemed to be more effective in the reduction of uveitis flares. PMID: 30620268 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study.
CONCLUSIONS: Our findings suggest that US can be used to diagnose/examine subjects in adulthood for pathological changes in the entheses; however, caution should be taken regarding enthesophytes of the quadriceps and Achilles tendon. PMID: 30620269 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Performance of 18F-sodium fluoride positron emission tomography with computed tomography to assess inflammatory and structural sacroiliitis on magnetic resonance imaging in axial spondyloarthritis.
CONCLUSIONS: Abnormal uptake by the SIJ on 18F-NaF PET is more frequent (87.0%) than inflammatory (43.5%) and structural sacroiliitis (65.2%) on MRI in a population of SpA patients. The PET activity score and SUVmax had good correlations with inflammatory sacroiliitis but not with structural lesions on MRI. PMID: 30620270 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Fibroblast-like synoviocytes from fluid and synovial membrane from primary osteoarthritis demonstrate similar production of interleukin 6, and metalloproteinases 1 and 3.
The objective of the study was to compare the production of metalloproteinases (MMP)-1, -3 and interleukin (IL)-6 by fibroblast-like synoviocytes (FLS) derived from synovial fluid (FD-FLS), and FLS derived from synovial tissue (TD-FLS) of patients with primary osteoarthritis (OA). The more accessible FD-FLS could facilitate the study of the role of these cells in OA pathophysiology. METHODS: MMP-1, MMP-3, and IL-6 levels were measured in the supernatant culture at baseline and 22 hours after stimulation with TNF-α and IL-1 β. RESULTS: There was no difference at baseline between MMP-1, MMP-3 and IL-6 prod...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between STAT4 polymorphisms and the risk of juvenile idiopathic arthritis in Han Chinese populations.
CONCLUSIONS: The G allele of rs11893432 was significantly associated with JIA risk, particularly oligoarticular JIA, in Han Chinese populations. SNPs at rs1018981 and rs10931481 were correlated with higher risk of polyarticular JIA. PMID: 30620272 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical peripheral enthesitis in the DESIR prospective longitudinal axial spondyloarthritis cohort.
CONCLUSIONS: This study highlights the high prevalence of peripheral enthesitis in recent onset axial spondyloarthritis, and suggests that in combination with peripheral arthritis, enthesitis might have an impact on the burden of the disease. PMID: 30620273 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System.
Authors: Gokoffski KK, Chatterjee A, Khaderi SK Abstract OBJECTIVES: Giant cell arteritis (GCA) is a vasculitis that affects large and medium sized arteries. The aetiology of GCA is unknown and numerous risk factors have been proposed. In this article, we evaluate the incidence of biopsy-positive GCA in Northern California and assess for seasonal variation. METHODS: We performed a retrospective review based on billing codes of temporal artery biopsies performed at the University of California, Davis from 2003 to 2014. RESULTS: We identified 174 biopsies (119 female, 55 male). Of these, 21 positive biopsies ...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: gout.
This article reviews the new clinical and experimental evidence about gout that emerged in 2017 and in the first half of 2018. PMID: 30620275 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Global metabolomic profiling of human synovial fluid for rheumatoid arthritis biomarkers.
CONCLUSIONS: This study supports the use of global metabolomic profiling by liquid chromatography-mass spectrometry for synovial fluid analysis to provide insight into the aetiology of disease. PMID: 30620276 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Early onset, non-rheumatic, group A streptococcal-associated myocarditis.
CONCLUSIONS: Non-RF GAS myocarditis typically affects healthy young males and represents about 3% of all hospitalised patients with myocarditis. These patients may be mistakenly diagnosed with an acute rheumatic fever or myocardial infarction. The prognosis in generally good following treatment with antibiotics and possibly NSAIDs. PMID: 30620277 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Choline metabolite, trimethylamine N-oxide (TMAO), is associated with inflammation in psoriatic arthritis.
CONCLUSIONS: In our cohort, only TMAO, but not TMA, choline, betaine or carnitine, was associated with inflammation in PsA patients, establishing a mechanistic link between TMAO and PsA phenotypes. Future studies will explore the modulation of TMAO and disease severity in PsA. PMID: 30620278 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum lysosomal-associated membrane protein-2 levels are increased in small and medium vessel vasculitis, especially in polyarteritis nodosa.
Authors: Li N, Zhu B, Zhu Q, Heizati M, Wu T, Wang G, Yao X, Luo Q, Liu S, Liu S Abstract OBJECTIVES: Lysosomal-associated membrane protein-2 (LAMP-2) is a highly glycosylated type I glycoprotein ex- pressed on the membranes of neutrophils, endothelial cells and other cells, which are closely linked to subsets of systematic vasculitis. The aim of this study was to investigate whether serum LAMP-2 can be used as a biomarker in small and medium vessel vasculitis (SMVV). METHODS: Serum samples from 39 patients with SMVV (including ANCA-associated vasculitis (AAV) and polyarteritis nodosa (PAN)) confirmed by angiog...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Geriatric syndromes in patients with rheumatoid arthritis: a literature overview.
Authors: Cleutjens FAHM, Boonen AERCH, van Onna MGB Abstract Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease of unknown aetiology which principally affects the small joints of the hands and feet. The incidence of RA increases with age and peaks within the age range of 70 to 79 years. In the ageing population, therefore, it is expected that the number of patients with RA will grow proportionally and more patients will have comorbidities but also so-called geriatric syndromes (GS). GS are clinical and multifactorial conditions in older persons that are associated with poor health outcomes, do no...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Are the cognitive functions of patients with rheumatoid arthritis associated with disease activity, with carotid atherosclerotic changes or with mood disorders such as depression and anxiety?
Authors: Manzo C Abstract PMID: 30620281 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasonographic detection of subclinical enthesitis and synovitis: a possible stratification of psoriatic patients without clinical musculoskeletal involvement.
Authors: Zuliani F, Zabotti A, Errichetti E, Tinazzi I, Zanetti A, Carrara G, Quartuccio L, Sacco S, Giovannini I, Stinco G, De Vita S Abstract OBJECTIVES: To evaluate the prevalence of articular/extra-articular inflammatory lesions and structural damage on ultrasonography in patients suffering from psoriasis as well as to assess possible correlations between ultrasonographic elementary lesions and clinical features. METHODS: Psoriatic patients without musculoskeletal symptoms and healthy controls (HCs) were recruited. All patients received a blinded extended ultrasonographic examination of 42 joints, 12 enthes...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum interleukin-17A level is associated with disease activity of adult patients with dermatomyositis and polymyositis.
Authors: Silva MG, Oba-Shinjo SM, Marie SKN, Shinjo SK Abstract OBJECTIVES: To assess serum interleukin (IL)-17A levels in patients with dermatomyositis (DM) and polymyositis (PM) and correlate them with the demographic, clinical, laboratory and therapeutic data of these diseases. METHODS: This was a cross-sectional, single-centre study that included defined DM and PM patients who were age-, gender- and ethnicity-matched to healthy individuals. Serum IL-17A analysis, as well as analysis for other cytokines (IL-6, TNFα and IFNγ), was performed by multiplex immunoassay. The disease status parameters w...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Analysis of potential determinants for a treat-to-target strategy in psoriatic arthritis patients from a real-world setting.
Authors: Lubrano E, Scriffignano S, De Socio A, Perrotta FM Abstract PMID: 30620284 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pain catastrophising worsens RAPID3 in all rheumatologic conditions.
CONCLUSIONS: Thanks to progress made in RA and SpA treatment, higher RAPID3 scores were mostly observed in other rheumatic conditions, but co-morbidities and pain catastrophising might contribute to floor effects when assessing rheumatic disorders with RAPID3, hindering the recognition of low disease activity in some RA of SpA patients. PMID: 30620285 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Attitudes about principle of autonomy in Hispanic patients from a dynamic early rheumatoid arthritis cohort.
CONCLUSIONS: Hispanic RA patients' sense of autonomy suggests paternalism in the physician-patient relationship. PMID: 30620286 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cysteine-rich protein 61 as a novel biomarker in systemic lupus erythematosus-associated pulmonary arterial hypertension.
CONCLUSIONS: Plasma Cyr61 level was significantly higher in SLE-PAH patients. Elevated circulating Cyr61 is a useful biomarker for identifying PAH in SLE, and it may serve as a promising indicator of prognosis in SLE-PAH. PMID: 30620287 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Interstitial lung pathology: should we test for autoantibodies to cellular antigens?
Authors: Serelis J, Athanasakos A, Skopouli FN, Moutsopoulos HM Abstract PMID: 30620288 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rituximab induces a lasting, non-cumulative remodelling of the B-cell compartment.
CONCLUSIONS: Rituximab induces a long-term reshape of the B-cell compartment while multiple cycles of rituximab do not induce cumulative effects on B-cell subpopulations. Transitional B-cells seem to be associated with higher disease activity, although further studies are needed to determine if they can be used as a biomarker to predict the need for rituximab retreatment. PMID: 30620289 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tacrolimus combined with corticosteroids effectively improved the outcome of a cohort of patients with immune-mediated necrotising myopathy.
Authors: Feng F, Li Y, Ji S, Wang Q, Bu B Abstract OBJECTIVES: To assess the efficacy and safety of tacrolimus in combination with corticosteroids in patients with immune-mediated necrotising myopathy. METHODS: The medical records of 20 hospitalised patients with immune-mediated necrotising myopathy (IMNM) who had received tacrolimus combined with oral prednisone from January 2014 to August 2017 were retrospectively reviewed. The recruited patients were shifted to the combined therapy because they failed to respond well to monotherapy with oral prednisone. The clinical efficacy during an average follow-up of 21...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Incidence of first cardiovascular event in Spanish patients with inflammatory rheumatic diseases: prospective data from the CARMA project.
CONCLUSIONS: Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older as well as having a long disease duration increase the risk of CVE in patients with CIRD. PMID: 30620291 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Correlation between quantitative and semiquantitative magnetic resonance imaging and histopathology findings in dermatomyositis.
Authors: Milisenda JC, Collado MV, Pinal-Fernandez I, Hormaza Jaramillo A, Faruch Bilfeld M, Cano MD, García AI, Tomás X, Grau JM Abstract OBJECTIVES: The aim of this study was to compare muscle biopsy findings, as well as clinical and analytical features, with those of magnetic resonance imaging (MRI) studies of muscle in patients with dermatomyositis. METHODS: All patients from the Longitudinal Myopathy Cohort of the Hospital Clínic de Barcelona were prospectively included in the study from 2009 to 2016. MRI images of muscle and fascial oedema were compared with muscle pathology results u...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Fibromyalgia in patients with rheumatoid arthritis. A 10-year follow-up study, results from the Oslo Rheumatoid Arthritis Register.
CONCLUSIONS: RA-FM was associated with significantly higher levels of cross-sectional and longitudinal RA disease activity. FM should be considered in patients with RA not reaching remission. PMID: 30620293 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Effect of Sinovial High-Low ® injections in trapeziometacarpal osteoarthritis.
Effect of Sinovial High-Low® injections in trapeziometacarpal osteoarthritis. Clin Exp Rheumatol. 2018 Dec 20; Authors: Bartoloni E, Luccioli F, La Paglia GMC, Cafaro G, Marcucci E, Gerli R Abstract PMID: 30620294 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Real world use of secukinumab for treatment of axial spondyloarthritis and psoriatic arthritis: nationwide results from the ATTRA registry.
Authors: Mann HF, Závada J, Šenolt L, Bubová K, Nekvindová L, Křístková Z, Horák P, Vencovský J, Pavelka K, and the ATTRA Registry Abstract PMID: 30620295 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Performance characteristics and predictors of temporal artery ultrasound for the diagnosis of giant cell arteritis in routine clinical practice in a prospective cohort.
Authors: Conway R, O'Neill L, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Killeen RP, Heffernan EJ, Molloy ES Abstract OBJECTIVES: The diagnosis of giant cell arteritis (GCA) is primarily a clinical one. Temporal artery (TA) ultrasound (US) has been proposed as a new diagnostic tool. We aimed to assess the performance characteristics of TA US in routine clinical practice. METHODS: All patients presenting with suspected GCA to our institution are recruited to a prospective registry. Patients who had both a TA US and biopsy (TAB) performed at the time of presentation were included in the current study. The perfor...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between fever pattern and clinical manifestations of adult-onset Still's disease: unbiased analysis using hierarchical clustering.
CONCLUSIONS: Hierarchical clustering identified three distinct fever patterns in patients with AOSD. Higher BT was associated with wider variations in diurnal temperature, higher risk of developing MAS, more intense treatment, and longer time to clinical remission, suggesting that fever pattern is a prognostic factor for AOSD. PMID: 30582502 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Epidemiological profile of non-infectious uveitis from the rheumatologist's perspective: a survey from two tertiary referral centres in Italy.
Authors: Lopalco G, Venerito V, Sota J, Rigante D, Guerriero S, Orlando I, Franceschini R, Favale R, Lapadula G, Castelli B, Frediani B, Galeazzi M, La Torre F, Iannone F, Tosi GM, Fabiani C, Cantarini L Abstract OBJECTIVES: To describe the epidemiology of non-infectious uveitis (NIU) in two tertiary referral rheumatology units in Central and Southern Italy. METHODS: Two hundred and seventy-eight consecutive NIU patients (417 eyes) evaluated between January 2016 and January 2017 were enrolled. Collected data were analysed in accordance with the primary anatomic site of inflammation, clinical course, and lateral...
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Faecal but not serum calprotectin levels look promising in predicting active disease in Beh çet's syndrome patients with gastrointestinal involvement.
CONCLUSIONS: FC, but not serum calprotectin seems to be a useful non-invasive tool for assessing disease activity in GIBS. Whether the presence of oral ulcers can cause false positive results remains to be studied. PMID: 30582504 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Concurrent chronic recurrent multifocal osteomyelitis and familial Mediterranean fever. A case report.
Authors: Lee JJY, Stimec J, Cameron B, Laxer RM Abstract PMID: 30582505 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Chronic non-bacterial osteomyelitis coexistent with familial Mediterranean fever.
Authors: Gezgin Yildirim D, Bedir Demirağ T, Akdulum İ, Yılmaz G, Bakkaloğlu S Abstract PMID: 30582506 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum immunoglobulin D levels in patients with Beh çet's disease according to different clinical manifestations.
CONCLUSIONS: Serum IgD levels are significantly increased in BD patients, especially among patients with active mucocutaneous manifestations, suggesting a possible role of IgD in BD pathogenesis and in the onset of mucosal and skin lesions. PMID: 30582507 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Echocardiographic findings of cardiovascular involvement in Beh çet's disease and post-operative complications after cardiac surgery.
CONCLUSIONS: The most common echocardiographic feature of cardiovascular involvement in BD is severe aortic regurgitation with prolapse of aortic cusps, vegetation-like mobile lesions, an echo-free space mimicking aortic root abscess or aortic aneurysm formation. Accurate preoperative diagnosis of BD is beneficial to the choice of immunosuppressive therapy before and after surgery, which is likely to reduce postoperative complications especially for patients with severe lesions. PMID: 30582508 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

18th International Conference on Beh çet's Disease.
18th International Conference on Behçet's Disease. Clin Exp Rheumatol. 2018 Nov-Dec;36 Suppl 115(6):152 Authors: van Laar JAM, van Hagen M Abstract PMID: 30582509 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Poster sessions.
Authors: Abstract PMID: 30582510 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Brain glucose consumption abnormalities in neuro-Beh çet's disease: a preliminary 18F-FDG PET/CT study.
Brain glucose consumption abnormalities in neuro-Behçet's disease: a preliminary 18F-FDG PET/CT study. Clin Exp Rheumatol. 2018 Nov-Dec;36 Suppl 115(6):148-149 Authors: D'Angelo S, Chiaravalloti A, Ursini F, Barbagallo G, Gilio M, Leccese P, De Giorgio R, Di Giorgio E, Schillaci O Abstract PMID: 30582511 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

New insights into Beh çet's disease in Ireland: the Midwest cohort study.
CONCLUSIONS: The prevalence of BD in Ireland is higher than previously reported with a significant proportion experiencing laryngeal destruction. There are many similarities as well as several differences in the epidemiology of BD by country and indeed within countries. We fully advocate the need for national and international collaborative efforts in order to further understand the complex aetiology and immunopathology of BD in order to improve the clinical, physical, psychological wellbeing of patients. PMID: 30582512 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Beh çet's syndrome and psychiatric involvement: is it a primary or secondary feature of the disease?
CONCLUSIONS: The study demonstrated a high frequency of psychiatric disorders in BS patients, peculiarly represented by bipolar disorders. The presence of this involvement, independently from the organ involvement, and strictly related to the disease activity, seems to suggest that neuro-psycho-BS may represent an intrinsic aspect of BS. PMID: 30582513 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Highlights of the 18th International Conference on Beh çet's syndrome.
Highlights of the 18th International Conference on Behçet's syndrome. Clin Exp Rheumatol. 2018 Nov-Dec;36 Suppl 115(6):3-12 Authors: Esatoglu SN, Kutlubay Z, Hatemi G Abstract PMID: 30582514 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Oral presentations.
Authors: Abstract PMID: 30582515 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: Beh çet's syndrome.
One year in review 2018: Behçet's syndrome. Clin Exp Rheumatol. 2018 Nov-Dec;36 Suppl 115(6):13-27 Authors: Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V Abstract New epidemiologic studies from Poland, Jordan, Algeria, Taiwan and Korea highlight the geographic differences in incidence, prevalence and clinical features of Behçet's syndrome (BS). A study from Austria comparing clinical manifestations of their BS patients with different countries of origin suggest that environmental factors may be important in the disease phenotype of BS. New genetic association studies dealing with...
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Potential role of pyrin, the protein mutated in familial Mediterranean fever, during inflammatory cell migration.
In this study, we examined the possible role of pyrin during inflammatory cell migration in neutrophils. We generated a cell migration assay with neutrophils and primary neutrophils from patients. We also knocked down pyrin expression using siRNA and then performed cell migration assay. We showed co-localisation of pyrin and F-actin at the leading edge during inflammatory cell migration. In pyrin knocked down cells, we identified a significant decrease in neutrophil migration. In addition, we demonstrated a dramatic increase in migration in the neutrophils of FMF patients compared with a healthy control group. These data t...
Source: Clinical and Experimental Rheumatology - December 26, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The effect of biologic agents on bone homeostasis in chronic inflammatory rheumatic diseases.
Authors: Di Munno O, Ferro F Abstract Osteoporosis (OP) and increased fracture risk are widely observed comorbidities in chronic inflammatory rheumatic diseases (CIRDs). Improved knowledge of the immune/inflammatory pathways, which characterise the pathophysiology of rheumatoid arthritis (RA) and seronegative spondyloarthropathies (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), have provided the link between inflammation and bone loss, via a complex network of bone cells, T and B cells, pro-inflammatory cytokines such as TNF-α, IL1, IL6, IL17, IL23, costimulator molecules, signalling...
Source: Clinical and Experimental Rheumatology - December 19, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tryptophan metabolism in rheumatoid arthritis is associated with rheumatoid factor and predicts joint pathology evaluated by the Rheumatoid Arthritis MRI Score (RAMRIS).
CONCLUSIONS: This study supports the hypothesis that tryptophan and its metabolites can be used as biomarkers predicting radiologic outcome and discriminate between RA and OA patients. Overall, our results strengthen the notion that tryptophan metabolism is closely linked to RA disease mechanisms. PMID: 30557125 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cognitive-behavioural and social factors do not predict recurrent secondary healthcare use in patients with fibromyalgia: a longitudinal study.
CONCLUSIONS: Our results suggest that the existence of comorbidities as communicated by the patient is the strongest warning signal for recurrent secondary healthcare use in FM. There seems no value in using cognitive-behavioural and social factors for early identification of patients with FM at risk for recurrent secondary healthcare use. PMID: 30557126 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Radiologist-rheumatologist multidisciplinary approach in the management of axial spondyloarthritis: a Delphi consensus statement.
CONCLUSIONS: This Delphi consensus statement provides an aid to rheumatologists and radiologists for the diagnosis and monitoring of axial-SpA. PMID: 30557127 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ixekizumab improves patient-reported outcomes in patients with active psoriatic arthritis and inadequate response to tumour necrosis factor inhibitors: SPIRIT-P2 results to 52 weeks.
CONCLUSIONS: In patients with PsA and an IR or intolerance to TNFi, ixekizumab significantly improved disease activity, skin symptoms, HRQOL, and work productivity to 52 weeks. PMID: 30557128 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research