Evaluating IBD-specific antiglycan antibodies in serum of patients with spondyloarthritis and rheumatoid arthritis: are they really specific?
CONCLUSIONS: Our data fail to show an increased prevalence of anti-glycan antibodies in AS or PsA patients. ACCA were found to be significantly higher in RA patients than in controls, and may serve as an inflammatory biomarker. The present results do not support a role for antiglycan antibodies as biomarkers for spondyloarthritis. PMID: 29998822 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The prevalence and relevance of traditional cardiovascular risk factors in primary Sj ögren's syndrome.
The prevalence and relevance of traditional cardiovascular risk factors in primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 May 30; Authors: Bartoloni E, Alunno A, Valentini V, Valentini E, La Paglia GMC, Leone MC, Cafaro G, Marcucci E, Bonifacio AF, Luccioli F, Gerli R Abstract Accelerated atherosclerosis is a distinct feature of some inflammatory and autoimmune disorders and several specific autoimmune mechanisms and persistent inflammation have been identified to exert a pivotal role in precocious atherosclerotic damage in these disorders. Although increased atherosclerotic risk has been we...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevention of the progressive biochemical cartilage destruction under methotrexate therapy in early rheumatoid arthritis.
CONCLUSIONS: Under MTX therapy, biochemical cartilage integrity remains stable; no further cartilage destruction occurred if patients were treated early in the course of the disease. In addition, six months of MTX therapy triggered an alignment of dGEMRIC index of MCP joints with initially severe synovitis and less severe synovitis in an intra-individual assessment. This underlines the importance of an early treatment in eRA to reduce further cartilage damage of the inflamed joints. PMID: 29998824 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rapid immunoprofiling of cytokines, chemokines and growth factors in patients with active rheumatoid arthritis using Luminex Multiple Analyte Profiling technology for precision medicine.
Authors: Bahlas S, Damiati L, Dandachi N, Sait H, Alsefri M, Pushparaj PN Abstract OBJECTIVES: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown etiology, characterised by symmetric erosive synovitis, leading inevitably to the destruction of cartilage and bone as well as bursa and tendon sheaths of joints. Our aim of this study was to decipher the differential expression of cytokines, chemokines and growth factors in the plasma of RA patients with active disease, using magnetic bead-based Luminex Multiple Analyte Profiling (xMAP) technology, for precision medicine. METHODS: We ob...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Limited efficacy of targeted treatments in Sj ögren's syndrome: why?
Limited efficacy of targeted treatments in Sjögren's syndrome: why? Clin Exp Rheumatol. 2018 Jun 21; Authors: Tzioufas AG, Goules AV PMID: 29998826 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Survival and safety of infliximab bio-original and infliximab biosimilar (CT-P13) in usual rheumatology care.
CONCLUSIONS: IB was well-tolerated and comparable to IO, with no additional safety signals identified. The results suggest superior survival of IB over IO over the first 2 years. PMID: 29998827 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Successful treatment with tofacitinib for renal disorder due to amyloid A amyloidosis and immunoglobulin A nephropathy in a patient with rheumatoid arthritis.
Authors: Watanabe T, Hattori T, Ogawa Y, Jodo S PMID: 29998828 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and safety of mycophenolate mofetil and tacrolimus combination therapy in patients with lupus nephritis: a nationwide multicentre study.
CONCLUSIONS: Our findings suggest that a combined MMF and TAC treatment, with a favourable adverse-event profile, may be a beneficial option for LN patients with inadequate response to either MMF or TAC treatments. PMID: 29998829 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Redundant modulatory effects of proinflammatory cytokines in human osteoblastic cells in vitro.
CONCLUSIONS: Overall, these results suggest that IL-17, TRAIL and TNF-α sustain bone tissue inflammation associated with decrease of calcified component. To do so, they act redundantly each other, to amplify the inflammatory response in the bone. In conclusion, unravelling novel molecular targets within the bone-cytokine network represents a platform for innovative treatment of bone diseases due to immunological diseases such as psoriatic arthritis. PMID: 29998830 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comparison between the efficacy of combination therapy and monotherapy in connective tissue disease associated pulmonary arterial hypertension: a systematic review and meta-analysis.
CONCLUSIONS: Combination therapy targeting PAH may confer preferable therapeutic efficacy compared with monotherapy in patients with CTD-PAH as evidenced by a more remarkable reduction in the risk of clinical worsening and a probable improvement of exercise capacity in these patients. PMID: 29998831 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Does early seronegative arthritis develop into rheumatoid arthritis? A 10-year observational study.
CONCLUSIONS: Over a 10-year follow-up period, reclassification revealed significant heterogeneity in the diagnosis of seronegative RA. Therefore, seronegative arthritis should not be studied as a homogenous entity. PMID: 29998832 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients.
CONCLUSIONS: Our results suggest that exposure to specific pathogenic periodontal bacteria influences disease activity in SLE patients. These findings provide a rationale for assessing and improving periodontal health in SLE patients, as an adjunct to lupus therapies. PMID: 29998833 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical characteristics and mortality rate of the Thai elderly onset systemic sclerosis.
CONCLUSIONS: Myopathy and limitation of physical activity were frequently found among elderly onset SSc over against pulmonary involvement than in adult onset SSc. Mortality of elderly onset SSc was 5.7 times higher, and median survival was 11 years shorter, than adult onset SSc. PMID: 29998834 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The majority of patients with psoriatic arthritis are not eligible for randomised clinical trials.
CONCLUSIONS: Our results demonstrate that two thirds of patients with PsA in Iceland who are treated with TNFi would not have qualified for the randomised clinical trials performed leading up to the registration of the medications. Further studies with regards to whether outcomes are different between those who met the inclusion criteria and those who did not remain to be performed. PMID: 29998835 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Quantification of skin stiffness in patients with systemic sclerosis using real-time shear wave elastography: a preliminary study.
Authors: Yang Y, Yan F, Wang L, Xiang X, Tang Y, Li Q, Xiaoyan L Abstract OBJECTIVES: To assess the diagnostic value of shear wave elastography (SWE) quantification in patients with systemic sclerosis (SSc) and healthy controls. METHODS: Skin elastic modulus (E) values and thicknesses were measured at 6 skin sites between the SSc (n=37) and control (n=37) groups. Thickness and E values were converted into T- and E-scores, to allow skin thickness and stiffness of different regions to be quantified based on a single standard. T- and E-scores were compared with the modified Rodnan skin score (mRSS). RESULTS: E...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reduction of peripheral natural killer cells in patients with SAPHO syndrome.
Authors: Xu D, Liu X, Lu C, Luo J, Wang C, Gao C, Xie J, Li X Abstract OBJECTIVES: Little is known about the roles of peripheral immune cell subsets in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. Up to now, just a few studies have focused on this issue. We aimed to analyse the distribution and phenotype of T cell subsets and natural killer (NK) cells in the peripheral blood of patients with SAPHO syndrome. METHODS: The proportion and absolute counts of circulating immune cells were assessed in 19 patients diagnosed as SAPHO syndrome and 19 healthy controls. CD4+T cell subsets were a...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Down-regulation of serum miR-151a-3p is associated with renal tissue activity in class IV lupus nephritis.
Authors: Xiao H, Wei N, Su M, Xiong Z Abstract OBJECTIVES: The aim of this study was to explore the value of serum miRNA for evaluating renal tissue activity in patients with class IV lupus nephritis (LN). METHODS: First, we used a microRNA array to identify miRNAs differentially expressed between class IV LN patients and healthy volunteers (n=4/group). Then, we analysed the association between these identified miRNAs and renal tissue activity in class IV LN patients. Finally, to validate the results, 20 class IV LN patients (confirmed by renal biopsy) and 20 healthy control volunteers were further studied. ...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Paediatric Beh çet's disease in Iran: report of 204 cases.
CONCLUSIONS: The clinical spectrum of PED-BD in Iran in this study was similar to that of other reports; however, genital ulcers, skin lesions (notably erythema nodosum), and gastrointestinal involvement were noticed to occur less frequently, while ocular lesions were more frequent and more severe compared to other reports. PMID: 29998839 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

What is metacarpophalangeal joint swelling in psoriatic arthritis? Ultrasound findings and reliability assessment.
CONCLUSIONS: Our study identifies that both IAS and PTI cause MCPj swelling, where PTI is almost as frequent as IAS as a cause of swelling. The reliability of PTI is at least as good as for IAS. PMID: 29998840 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Short-term costs associated with non-medical switching in autoimmune conditions.
CONCLUSIONS: Originator-to-biosimilar NMS in stable patients with autoimmune conditions could result in considerable switching costs for both providers and payers. PMID: 29998841 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasound detection of subclinical synovitis in rheumatoid arthritis patients in clinical remission: a new reduced-joint assessment in 3 target joints.
CONCLUSIONS: The US scan of 3 target joints showed a high sensitivity in detecting subclinical active synovitis in RA patients in clinical remission and can be feasible in the routine assessment of these patients. PMID: 29998842 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Duration of anti-TNF treatment in vascular Beh çet's disease: better to prolong treatment?
Duration of anti-TNF treatment in vascular Behçet's disease: better to prolong treatment? Clin Exp Rheumatol. 2018 May 31; Authors: Atas N, Babaoglu H, Varan O, Tufan A PMID: 29998843 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Overweight and obesity affect clinical assessment of synovitis in rheumatoid arthritis: comparison of ultrasonography and clinical exam.
CONCLUSIONS: In high BMI RA patients both SJC and DAS28 seem to be undervalued by clinical assessment when compared to US. PMID: 29998844 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Why male patients with Beh çet's disease prone to thrombosis? A rotational thromboelastographic analysis.
Why male patients with Behçet's disease prone to thrombosis? A rotational thromboelastographic analysis. Clin Exp Rheumatol. 2018 Jun 08; Authors: Kara Kivanc B, Gönüllü E, Akay OM, Ertürk A, Bal C, Cansu DÜ, Korkmaz C Abstract OBJECTIVES: To investigate whether there is a difference between male and female patients with Behçet's disease (BD) in terms of hypercoagulability by using modified rotational thromboelastograhic (ROTEM) analysis. METHODS: 126 BD patients (71 male, 55 female; mean age: 41±9 yrs) who met ISSG criteria for BD were included into th...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Relationship between cerebrovascular and valvular manifestations in a Serbian cohort of patients with antiphospholipid syndrome.
CONCLUSIONS: In this cross-section analysis of a large cohort of Serbian APS patients, there was a strong relationship between valvular and cerebrovascular manifestations, suggesting a more cautious approach regarding neurological symptoms, especially in PAPS patients with valvular vegetations present. PMID: 29846156 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Role of serum autoantibodies in blood brain barrier damages in neuropsychiatric systemic lupus erythematosus.
CONCLUSIONS: The data demonstrate that serum anti-Sm antibodies play a most important role in the disruption of BBB in NPSLE. PMID: 29846157 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Peripheral nervous system involvement in systemic lupus erythematosus: a review of the evidence.
Authors: Bortoluzzi A, Silvagni E, Furini F, Piga M, Govoni M Abstract In the past years the peripheral nervous system (PNS) involvement in systemic lupus erythematosus (SLE) has received little attention despite its potential significant impact. The true prevalence of PNS in SLE reported in studies is variable and strongly influenced by American College of Rheumatology (ACR) case definition that includes seven PNS manifestations (acute inflammatory demyelinating polyradiculoneuropathy, autonomic disorder, mononeuropathy, myasthenia gravis, cranial neuropathy, plexopathy and polyneuropathy). Other peripheral manife...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Entheseal involvement in asymptomatic human immunodeficiency virus infected patients: preliminary results of a clinical and ultrasonographic study.
Authors: Ciancio G, Sighinolfi L, Furini F, Segala D, Farina I, Galuppi E, De Stefani E, Simone L, Boccia S, Grilli A, Pazzi P, Libanore M, Contini C, Govoni M Abstract OBJECTIVES: As a strong association between human immunodeficiency virus (HIV) infection and spondyloarthritis (SpA) has been hypothesised, our main objective was to explore by power Doppler ultrasonography (PDUS) the presence of subclinical enthesitis in asymptomatic HIV patients. The presence of subclinical synovitis was also evaluated. METHODS: Consecutive asymptomatic HIV patients were studied and compared with asymptomatic HCV patients and ...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rheumatic diseases and pregnancy: a national survey about practice patterns among rheumatologists and obstetricians.
Authors: Fayad F, Ziade N, Karam GA, Ghaname W, Khamashta M Abstract OBJECTIVES: Management of rheumatic diseases (RD) is often problematic in pregnant patients, hence the need for guideline implementation. This survey-based study aimed to assess beliefs among obstetricians and rheumatologists about managing RD in pregnant Lebanese patients. METHODS: Questionnaires were completed by a representative sample of rheumatologists and obstetricians practicing throughout Lebanon. Collected data included physicians' information, opinion on pregnancy in RD patients, compatible drugs with fertility, pregnancy and breastf...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence and spectrum of symptomatic pulmonary involvement in primary Sj ögren's syndrome.
CONCLUSIONS: Approximately one fifth of a large cohort of pSS patients presented chronic respiratory symptoms. Small airway disease was the most commonly recognized pulmonary disorder among symptomatic pSS patients, followed by xerotrachea and interstitial lung disease. PMID: 29846161 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Appropriate cardiovascular disease risk assessment in systemic lupus erythematosus may be lacking in rheumatology practice.
CONCLUSIONS: CV risk assessment and preventative measures were inconsistent when rheumatologists monitored SLE patients, indicating a care gap. Improved communication between rheumatologists and family physicians with respect to elevated CVD risk in SLE is needed. PMID: 29846162 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Expression profile of long noncoding RNAs in children with systemic lupus erythematosus: a microarray analysis.
CONCLUSIONS: We firstly characterised the expression profiles of lncRNA and mRNA in children with SLE and propose herein their possible roles in the pathogenesis of SLE. These results provide novel insights into the mechanisms of SLE pathogenesis and may serve as diagnostic biomarkers for SLE therapy. PMID: 29846163 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sj ögren's syndrome: disease activity indexes! Do they make us better clinicians or technicians?
Sjögren's syndrome: disease activity indexes! Do they make us better clinicians or technicians? Clin Exp Rheumatol. 2018 May 25; Authors: Moutsopoulos HM, Skopouli FN PMID: 29846164 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Risk factors of relapse following glucocorticoid tapering in IgG4-related disease.
CONCLUSIONS: Higher levels of serum IgG4 at baseline were associated with relapse in IgG4-RD. Re-elevation of serum IgG4 levels during GC treatment reflected disease relapse. PMID: 29846165 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Vitamin D deficiency in connective tissue disease-associated interstitial  lung disease.
Vitamin D deficiency in connective tissue disease-associated interstitial lung disease. Clin Exp Rheumatol. 2018 May 24; Authors: Deng M, Tang L, Huang D, Wang Z, Chen J Abstract OBJECTIVES: To determine and compare the prevalence of vitamin D deficiency in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). METHODS: The level of vitamin D was determined by the serum levels of 1,25(OH)2D3. We evaluated 144 patients in our study, including 53 subjects in the CTD-ILD group and 91 subjects in the CTD group without ILD. CTD was diagnosed following the Ameri...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Systemic lupus erythematosus in PubMed: a review of the articles published in 2016.
Authors: Jiménez Alonso J, Vargas Hitos JA, Zamora Pasadas M, Navarrete Navarrete N, Jáimez L, Sabio JM PMID: 29846167 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

IgG4-related disease: features and treatment response in a multi-ethnic cohort in Singapore.
CONCLUSIONS: Pancreatitis, lymphoadenopathy and cholangitis were the commonest manifestations in Asians with IgG4-RD. All patients responded to glucocorticoid therapy by 3 months, two-thirds required maintenance therapy with glucocorticoids, and one-quarter developed relapse of disease. PMID: 29846168 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: novelties in the treatment of rheumatoid arthritis.
Authors: Bortoluzzi A, Furini F, Generali E, Silvagni E, Luciano N, Scirè CA Abstract The current approach to treatment of rheumatoid arthritis (RA) includes early and aggressive intervention aiming to reach early and persistent low disease activity and remission. New drugs have improved the therapeutic armamentarium of rheumatologists, providing new options for patients. Beyond these innovations, new evidence has improved the safety of therapies and provided tools for the optimisation of long-term management of RA. This paper reviews the most relevant studies published over the last year in the field of tre...
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Subclinical aortitis after starting nivolumab in a patient with metastatic melanoma. A case of drug-associated aortitis?
Authors: Loricera J, Hernández JL, García-Castaño A, Martínez-Rodríguez I, González-Gay MÁ, Blanco R PMID: 29799390 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Manifestation of granulomatosis with polyangiitis in head and neck.
CONCLUSIONS: The data of the largest monocentric study presented here demonstrate a frequent ENT-involvement in GPA patients. Rhinological and ontological manifestations are most common. PMID: 29799391 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Highlights of the 2nd EUVAS Vasculitis Course.
Authors: Emmi G, Salvarani C, Prisco D, Jayne DRW, Vaglio A PMID: 29799392 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Distribution patterns of 18F-fluorodeoxyglucose in large vessels of Takayasu's and giant cell arteritis using positron emission tomography.
Authors: Soriano A, Pazzola G, Boiardi L, Casali M, Muratore F, Pipitone N, Catanoso M, Aldigeri R, Cimino L, Versari A, Salvarani C Abstract OBJECTIVES: To compare patterns of vascular involvement using 18F-fluorodeoxyglucose-positron emission tomography computed tomography (FDG PET/CT) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK). METHODS: A total of 130 consecutive 18F-FDG PET/CT scans performed during the disease course for evaluating disease activity in 15 GCA and 13 TAK patients were retrospectively examined by two nuclear physicians blinded to clinical data. Standardised upt...
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rate of infections in severe necrotising vasculitis patients treated with cyclophosphamide induction therapy: a meta-analysis.
CONCLUSIONS: The rate of severe infections and infection related mortality in patients with severe necrotising vasculitis treated with CYC + GC induction therapy is high. PMID: 29799394 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: systemic vasculitis.
Authors: Elefante E, Bond M, Monti S, Lepri G, Cavallaro E, Felicetti M, Calabresi E, Posarelli C, Talarico R, Quartuccio L, Baldini C Abstract Systemic vasculitis are heterogeneous, complex and disabling disorders. Following the previous annual reviews of this series, this paper gives a brief overview on current knowledge about recent literature on small- and large-vessel systemic vasculitis, with a specific focus on pathogenetic and clinical aspects, novel possible disease-related biomarkers and current and future therapies that are in the pipeline. PMID: 29799395 [PubMed - in process] (Source: Clinical and E...
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Circulating CD4+CD8+ double-positive T-cells display features of innate and adaptive immune function in granulomatosis with polyangiitis.
CONCLUSIONS: Employing a combined phenotypic and transcriptomic approach we disclosed a Th1/Th17 phenotype as well as innate and adaptive functions of CD4+CD8+ double-positive T-cells in GPA. PMID: 29799396 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Parasympathetic activity increases with digital microvascular damage and vascular endothelial growth factor in systemic sclerosis.
Authors: Gigante A, Margiotta D, Navarini L, Liberatori M, Barbano B, Tubani L, Afeltra A, Rosato E Abstract OBJECTIVES: The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF). METHODS: Twenty-seven SSc patients ...
Source: Clinical and Experimental Rheumatology - May 23, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Venous thrombosis and relapses in patients with Beh çet's disease. Descriptive analysis from Spanish network of Behçet's disease (REGEB cohort).
CONCLUSIONS: We identified factors related with venous involvement in patients included in the REGEB cohort. PMID: 29745871 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Effects of autonomic dysfunction on exercise tolerance in systemic sclerosis patients without clinical and instrumental evidence of cardiac and pulmonary involvement.
CONCLUSIONS: In SSc patients without cardiopulmonary involvement AD is associated with better exercise tolerance and cardiac function during physical effort. Further studies are needed to confirm these results. PMID: 29745872 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Do antimalarials protect against damage accrual in primary Sj ögren's syndrome? Results from a Latin-American retrospective cohort.
Do antimalarials protect against damage accrual in primary Sjögren's syndrome? Results from a Latin-American retrospective cohort. Clin Exp Rheumatol. 2018 Apr 19; Authors: Hernández-Molina G, Valim V, Secco A, Atisha-Fregoso Y, Guerra E, Adrover M, Lage Santos AJ, Catalán-Pellet A Abstract OBJECTIVES: To assess the use of antimalarials and to evaluate their association with damage accrual in a Latino-American cohort of patients with primary Sjögren's syndrome (pSS). METHODS: We included 377 patients attending three tertiary referral centers from: Argentina (n=110), Brazil (...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Strong correlation between cancer progression and anti-transcription intermediary factor 1 γ antibodies in dermatomyositis patients.
This study aims to identify the clinical characteristics of cancers in anti-ΤΙF1γ antibody-positive adult patients with DM. METHODS: This retrospective analysis covered 160 adult DM patients who visited Nagoya University Hospital or collaborating medical centres between 2003 and 2016. Anti-TIF1γ antibody and other myositis-specific autoantibodies were detected by ELISA. Based on a review of medical charts, the cancers were staged according to the TNM Classification of Malignant Tumours of the Union for International Cancer Control and were divided into the two groups of "advanced" or &quo...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research