Roles of autophagy in rheumatoid arthritis
Clin Exp Rheumatol. 2022 Sep 22. doi: 10.55563/clinexprheumatol/exg1ic. Online ahead of print.ABSTRACTAutophagy, a vital mechanism restricted in tissues, exerts its cytoprotective role through the degradation mechanism of damaged or aging organelles, harmful protein aggregates and intracellular pathogens, followed by energy furnishment. However, dysfunctional autophagy is associated with the development of autoimmune diseases such as rheumatoid arthritis (RA). In pathological conditions, autophagy may be involved in the maturation, survival and proliferation of various immune and non-immune cells and plays a key role in th...
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Jia-Tong Ding Fen-Fang Hong Shu-Long Yang Source Type: research

Race, ethnicity and patient-reported outcomes in childhood-onset systemic lupus erythematosus
CONCLUSIONS: In this multiethnic paediatric lupus cohort, PROMIS global health was lower when compared with the general paediatric US population. Moreover, PROMIS global health, pain interference, and physical function mobility did not vary across races/ethnicities.PMID:36135940 | DOI:10.55563/clinexprheumatol/tn0x4k (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: R Ezequiel Borgia Matthew J Gurka Stephanie L Filipp Melissa Elder Michelle Cardel Natalie J Shiff CARRA Registry Investigators Source Type: research

Prognostic value of right atrial stiffness in systemic sclerosis
CONCLUSIONS: RA stiffness is associated with all-cause mortality in SSc patients without PAH independent of and incremental to the RV longitudinal systolic function. It may be proposed as non-invasive marker for identifying patients with high mortality risk.PMID:36135944 | DOI:10.55563/clinexprheumatol/3vdmeh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Ágnes Nógrádi Zsuzsanna Varga M áté Hajdu L ászló Czirják Andr ás Komócsi R éka Faludi Source Type: research

Reactogenicity, safety and disease flares following BNT162b2 mRNA COVID-19 vaccine in patients with chronic immune-inflammatory arthritis treated with biological and targeted synthetic disease-modifying anti-rheumatic drugs
CONCLUSIONS: The safety of mRNA COVID-19 vaccination in arthritis patients on treatment with b/tsDMARDs is reassuring. In a regimen of peri-vaccine drug interruption, transient flares of the disease more commonly occur in association with active arthritis and use of shorter half-life drugs. Most flares do not require treatment escalation or change.PMID:36135948 | DOI:10.55563/clinexprheumatol/0ltj1i (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Ludovico De Stefano Silvia Balduzzi Laura Bogliolo Bernardo D'Onofrio Michele di Lernia Eleonora Mauric Alessandra Milanesi Fabio Brandolino Clarissa Rocca Sofia Chiricolo Antonio Manzo Carlomaurizio Montecucco Serena Bugatti Source Type: research

Tacrolimus therapy in primary Sj ögren's syndrome with refractory immune thrombocytopenia: a retrospective study
CONCLUSIONS: TAC is effective and well tolerated by pSS patients with RITP, and the mechanism underlying the effect of TAC in these patients may be related to reduced Th1 cytokine expression.PMID:36135951 | DOI:10.55563/clinexprheumatol/5c7l01 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Rong Xu Qing Yan Yan Gong Cheng-Sen Cai Jian Wu Xin-Yu Yuan Xian-Ming Long Source Type: research

Incidence of autoantibodies related to systemic autoimmunity in patients with severe COVID-19 admitted to the intensive care unit
CONCLUSIONS: Patients with severe COVID-19 express AAbs more commonly compared to controls. No correlation was found between AAbs and disease outcome.PMID:36135957 | DOI:10.55563/clinexprheumatol/2remcx (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Kleopatra Bitzogli Edison Jahaj Athanasios-Dimitrios Bakasis Efstathia K Kapsogeorgou Andreas V Goules Ioanna Stergiou Vasilis Pezoulas Christina Antoniadou Panagiotis Skendros Konstantinos Ritis Dimitrios I Fotiadis Anastasia Kotanidou Athanasios G Tziou Source Type: research

Systemic sclerosis: one year in review 2022
Clin Exp Rheumatol. 2022 Sep 21. doi: 10.55563/clinexprheumatol/3401fl. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy, immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into the pathogenesis, organ involvement and treatment of this severe disease are published in the scientific community.In this review we report an overview of some of the most relevant contributions published in 2021.PMID:36135958 | DOI:10.55563/clinexprheumatol/3401fl (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Gemma Lepri Martina Orlandi Marco Di Battista Gianmarco De Mattia Mattia Da Rio Veronica Codullo Serena Guiducci Alessandra Della Rossa Source Type: research

Roles of autophagy in rheumatoid arthritis
Clin Exp Rheumatol. 2022 Sep 22. doi: 10.55563/clinexprheumatol/exg1ic. Online ahead of print.ABSTRACTAutophagy, a vital mechanism restricted in tissues, exerts its cytoprotective role through the degradation mechanism of damaged or aging organelles, harmful protein aggregates and intracellular pathogens, followed by energy furnishment. However, dysfunctional autophagy is associated with the development of autoimmune diseases such as rheumatoid arthritis (RA). In pathological conditions, autophagy may be involved in the maturation, survival and proliferation of various immune and non-immune cells and plays a key role in th...
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Jia-Tong Ding Fen-Fang Hong Shu-Long Yang Source Type: research

Race, ethnicity and patient-reported outcomes in childhood-onset systemic lupus erythematosus
CONCLUSIONS: In this multiethnic paediatric lupus cohort, PROMIS global health was lower when compared with the general paediatric US population. Moreover, PROMIS global health, pain interference, and physical function mobility did not vary across races/ethnicities.PMID:36135940 | DOI:10.55563/clinexprheumatol/tn0x4k (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: R Ezequiel Borgia Matthew J Gurka Stephanie L Filipp Melissa Elder Michelle Cardel Natalie J Shiff CARRA Registry Investigators Source Type: research

Prognostic value of right atrial stiffness in systemic sclerosis
CONCLUSIONS: RA stiffness is associated with all-cause mortality in SSc patients without PAH independent of and incremental to the RV longitudinal systolic function. It may be proposed as non-invasive marker for identifying patients with high mortality risk.PMID:36135944 | DOI:10.55563/clinexprheumatol/3vdmeh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Ágnes Nógrádi Zsuzsanna Varga M áté Hajdu L ászló Czirják Andr ás Komócsi R éka Faludi Source Type: research

Reactogenicity, safety and disease flares following BNT162b2 mRNA COVID-19 vaccine in patients with chronic immune-inflammatory arthritis treated with biological and targeted synthetic disease-modifying anti-rheumatic drugs
CONCLUSIONS: The safety of mRNA COVID-19 vaccination in arthritis patients on treatment with b/tsDMARDs is reassuring. In a regimen of peri-vaccine drug interruption, transient flares of the disease more commonly occur in association with active arthritis and use of shorter half-life drugs. Most flares do not require treatment escalation or change.PMID:36135948 | DOI:10.55563/clinexprheumatol/0ltj1i (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Ludovico De Stefano Silvia Balduzzi Laura Bogliolo Bernardo D'Onofrio Michele di Lernia Eleonora Mauric Alessandra Milanesi Fabio Brandolino Clarissa Rocca Sofia Chiricolo Antonio Manzo Carlomaurizio Montecucco Serena Bugatti Source Type: research

Tacrolimus therapy in primary Sj ögren's syndrome with refractory immune thrombocytopenia: a retrospective study
CONCLUSIONS: TAC is effective and well tolerated by pSS patients with RITP, and the mechanism underlying the effect of TAC in these patients may be related to reduced Th1 cytokine expression.PMID:36135951 | DOI:10.55563/clinexprheumatol/5c7l01 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Rong Xu Qing Yan Yan Gong Cheng-Sen Cai Jian Wu Xin-Yu Yuan Xian-Ming Long Source Type: research

Incidence of autoantibodies related to systemic autoimmunity in patients with severe COVID-19 admitted to the intensive care unit
CONCLUSIONS: Patients with severe COVID-19 express AAbs more commonly compared to controls. No correlation was found between AAbs and disease outcome.PMID:36135957 | DOI:10.55563/clinexprheumatol/2remcx (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Kleopatra Bitzogli Edison Jahaj Athanasios-Dimitrios Bakasis Efstathia K Kapsogeorgou Andreas V Goules Ioanna Stergiou Vasilis Pezoulas Christina Antoniadou Panagiotis Skendros Konstantinos Ritis Dimitrios I Fotiadis Anastasia Kotanidou Athanasios G Tziou Source Type: research

Systemic sclerosis: one year in review 2022
Clin Exp Rheumatol. 2022 Sep 21. doi: 10.55563/clinexprheumatol/3401fl. Online ahead of print.ABSTRACTSystemic sclerosis (SSc) is an autoimmune disease characterised by microvasculopathy, immune dysregulation, and skin and visceral organ fibrosis. Every year novel insights into the pathogenesis, organ involvement and treatment of this severe disease are published in the scientific community.In this review we report an overview of some of the most relevant contributions published in 2021.PMID:36135958 | DOI:10.55563/clinexprheumatol/3401fl (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Gemma Lepri Martina Orlandi Marco Di Battista Gianmarco De Mattia Mattia Da Rio Veronica Codullo Serena Guiducci Alessandra Della Rossa Source Type: research

Roles of autophagy in rheumatoid arthritis
Clin Exp Rheumatol. 2022 Sep 22. doi: 10.55563/clinexprheumatol/exg1ic. Online ahead of print.ABSTRACTAutophagy, a vital mechanism restricted in tissues, exerts its cytoprotective role through the degradation mechanism of damaged or aging organelles, harmful protein aggregates and intracellular pathogens, followed by energy furnishment. However, dysfunctional autophagy is associated with the development of autoimmune diseases such as rheumatoid arthritis (RA). In pathological conditions, autophagy may be involved in the maturation, survival and proliferation of various immune and non-immune cells and plays a key role in th...
Source: Clinical and Experimental Rheumatology - September 22, 2022 Category: Rheumatology Authors: Jia-Tong Ding Fen-Fang Hong Shu-Long Yang Source Type: research