Clinical, histologic and prognostic features of clinically amyopathic dermatomyositis
CONCLUSIONS: CADM patients differ in disease onset, autoantibody profiles, joint and lung involvement. While laboratory and instrumental tests have not shown muscle involvement in CADM, many muscle biopsies have shown MHC-I overexpression.PMID:38488091 | DOI:10.55563/clinexprheumatol/kgpnbq (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Francesco Girolamo Margherita Giannini Laura Coladonato Adriana Capuano Marco Capodiferro Dario D'Abbicco Maddalena Ruggieri Mariangela Mastrapasqua Florenzo Iannone Source Type: research

Nailfold capillaroscopy findings of a multicentric multi-ethnic cohort of patients with idiopathic inflammatory myopathies
CONCLUSIONS: NVC abnormalities are related to the diagnosis, clinical features, disease activity, and autoantibodies of patients with IIM.PMID:38488092 | DOI:10.55563/clinexprheumatol/l9gudh (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Jiram Torres-Ruiz Iago Pinal-Fernandez Albert Selva-O'Callaghan Bianca Campbell Sandra Mu ñoz-Braceras Nancy R Mej ía-Domínguez Carlos N úñez-Álvarez Jos é Milisenda Maria Casal-Dom ínguez Katherine Pak Alfredo Guill én-Del-Castillo Ernesto Trall Source Type: research

Mental health in paediatric and adult myositis-related diseases: current state of research, interventions, and future steps from the MIHRA Psychological Impact Scientific Working Group
Clin Exp Rheumatol. 2024 Feb;42(2):413-424. doi: 10.55563/clinexprheumatol/cngdfn. Epub 2024 Mar 14.ABSTRACTPsychological and emotional well-being are critical aspects of overall health for individuals with chronic rheumatologic conditions. Mental health-related literature, however, predominantly focuses on systemic lupus erythematosus or rheumatoid arthritis, with limited emphasis on idiopathic inflammatory myopathies (IIMs). High proportions of those with juvenile myositis report psychological distress at levels warranting mental health referral. Adults with dermatomyositis diagnosed with depression or anxiety do not rec...
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Aviya Lanis Helene Alexanderson Kaveh Ardalan Suzanne Edison Christopher D Graham Ingrid de Groot Latika Gupta Susan Kim Andrea M Knight Linda Kobert Polly Livermore Christian Lood Clarissa Pilkington Malin Regardt Tamar B Rubinstein Susan Shenoi Luke Tur Source Type: research

Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank
CONCLUSIONS: Our study evaluates the performance of real-world identification of anti-synthetase antibodies in a large cohort of multi-national patients with ASSD and controls. Our analysis reinforces the reliability of real-world anti-Jo1 detection methods. In contrast, challenges persist for anti-non-Jo1 identification, particularly anti-PL7 and rarer antibodies such as anti-OJ/KS. Clinicians should exercise caution when interpreting anti-synthetase antibodies, especially when commercial immunoassays test positive for non-anti-Jo1 antibodies.PMID:38488094 | DOI:10.55563/clinexprheumatol/s14zq8 (Source: Clinical and Exper...
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Aravinthan Loganathan Giovanni Zanframundo Akira Yoshida Sara Faghihi-Kashani Iazsmin Bauer Ventura Eduardo Dourado Francisca Bozan Gianluca Sambataro Yasuhiko Yamano Sharon Sangmee Bae Darosa Lim Angela Ceribelli Natasa Isailovic Carlo Selmi Noreen Ferti Source Type: research

Polymyositis is a rare and favourable outcome subtype of idiopathic inflammatory myopathy in Chinese patients
CONCLUSIONS: Strictly defined typical PM is a rare clinical subtype in Chinese IIM patients. Typical PM patients with classical pathology were MSA-negative and responded well to treatment and had a favourable prognosis. It is crucial for clinicians to combine clinical, serological, and pathological features to properly distinguish PM from other IIM subtypes.PMID:38488095 | DOI:10.55563/clinexprheumatol/7v9d2x (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Chao Sun Xiaolan Tian Hongxia Yang Hanbo Yang Shanshan Li Wei Jiang Qinglin Peng Guochun Wang Xin Lu Source Type: research

Subclinical myocardial involvement in a cohort of patients with antisynthetase syndrome
CONCLUSIONS: Subclinical myocardial involvement in ASSD is not rare (32%) although its clinical significance is uncertain. Myocardial oedema (T2) was the most frequent finding, followed by increased T1 and/or ECV values likely signalling interstitial fibrosis. Of note, patients in the acute phase showed elevated T2 values.PMID:38488096 | DOI:10.55563/clinexprheumatol/tgcrtf (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Albert Gil-Vila Gemma Burcet-Rodriguez Ernesto Trallero-Aragu ás Hug Cuellar-Calabria Albert Selva-O'Callaghan Source Type: research

Cancer-associated myositis before and after the COVID-19 pandemic onset: a changing trend
CONCLUSIONS: There was a significant increase in the incidence of CAM after the COVID-19 pandemic. IIM diagnosis after the COVID-19 pandemic was an independent predictor of CAM.PMID:38488097 | DOI:10.55563/clinexprheumatol/jv9ey8 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Filipa M Costa Raquel Campanilho-Marques Eduardo Dourado Matilde Bandeira Bianca Correia Ana Teresa Melo Fernando Saraiva Sofia C Barreira Jo ão Eurico Fonseca Source Type: research

Anti-SAE dermatomyositis: clinical and histologic characteristics from a monocentric Italian cohort
CONCLUSIONS: Anti-SAE DM represents a disease subset characterised by classic cutaneous involvement often associated with itching, less severe muscle involvement, but potential pulmonary involvement that should always be investigated in these patients.PMID:38488098 | DOI:10.55563/clinexprheumatol/110r0p (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Marco Fornaro Laura Coladonato Margherita Giannini Angelica Napoletano Francesco Girolamo Dario D'Abbicco Maddalena Ruggieri Daniele Vito Andrea Sabella Florenzo Iannone Source Type: research

Idiopathic inflammatory myopathies: one year in review 2023
Clin Exp Rheumatol. 2024 Feb;42(2):213-224. doi: 10.55563/clinexprheumatol/dh5o6c. Epub 2024 Mar 14.ABSTRACTIdiopathic inflammatory myopathies are a group of rare, autoimmune, diseases typically involving striate muscle and also variously affecting several other systems or organs, such as joints, skin, lungs, heart and gastrointestinal tract. IIM are mainly characterised by subacute onset and chronic course and are burdened by significant morbidity and mortality. Despite the rarity of these conditions, several efforts have been undertaken in the last years to better understand their pathogenesis, as well as to achieve a mo...
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Edoardo Conticini Eduardo Dourado Francesca Bottazzi Chiara Cardelli Lorenza Bruno Jens Schmidt Linda Carli Lorenzo Cavagna Simone Barsotti Source Type: research

5th Global Conference on Myositis (GCOM)
Clin Exp Rheumatol. 2024 Feb;42(2):465-582. doi: 10.55563/clinexprheumatol/byxxv1. Epub 2024 Mar 11.NO ABSTRACTPMID:38488100 | DOI:10.55563/clinexprheumatol/byxxv1 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Victoria Werth Erin M Wilfong Andrew L Mammen Chester V Oddis Didem Saygin Vladimir M Liarski Siamak Moghadam-Kia Rohit Aggarwal Dana P Ascherman Source Type: research

Hearing loss in Takayasu's arteritis
CONCLUSIONS: Our study reveals an increased prevalence of hearing loss in TAK. Further research is crucial to uncover the underlying causes.PMID:38489315 | DOI:10.55563/clinexprheumatol/gtd2uv (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Ugur Kimyon Emine Deniz G özen Ebru Karaman Elif Emel G ünay Sinem Nihal Esatoglu Ahmet Atas Emin Karaman Emire Seyahi Source Type: research

Role of TLR7 in the pathogenesis of primary Sj ögren's syndrome
This article explores the mechanisms of TLR7 dysregulation, its involvement in pSS pathogenesis, and prospective therapeutic significance.PMID:38489320 | DOI:10.55563/clinexprheumatol/cmmkod (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Yue Song Wei Zhou Source Type: research

Potential efficacy of T and B lymphocyte-targeted therapies on articular involvement of patients with rheumatoid arthritis and systemic sclerosis overlap syndrome. Results from a 2-centre series of 22 cases
CONCLUSIONS: In patients with RA/SSc overlap syndrome refractory to conventional synthetic-DMARDs, T and B lymphocyte-targeted therapies seem to be a promising therapeutic option to control joint activity.PMID:38489323 | DOI:10.55563/clinexprheumatol/0znf7e (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Nans Lebel Isabelle Marie Julien Grosjean Pauline Brevet Mathilde Leclercq Ana ël Dumont Herv é Levesque Ygal Benhamou Christian Marcelli Thierry Lequerre Olivier Vittecoq Source Type: research

A giant tongue ulcer: don't miss the treatable cause!
Clin Exp Rheumatol. 2024 Mar 13. doi: 10.55563/clinexprheumatol/pfen28. Online ahead of print.NO ABSTRACTPMID:38489341 | DOI:10.55563/clinexprheumatol/pfen28 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Mustafa Erdogan Seckin Bilgic Izzet Fresko Source Type: research

Screening for pulmonary arterial hypertension in patients with systemic sclerosis in the era of new pulmonary arterial hypertension definitions
CONCLUSIONS: With the recent criteria, PAH diagnosis in patients with SSc increased by 1.8-fold. Current algorithms for screening PAH are less sensitive with these revised criteria. Although the ASIG algorithm seems more sensitive, it can still miss the diagnosis. The multimodal/algorithmic approach seems to be the best option for predicting PAH.PMID:38489342 | DOI:10.55563/clinexprheumatol/gzo4r2 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Mustafa Erdogan Burcak Kilickiran Avci Cansu Ebren Yagmur Ersoy Zeki Ongen Gul Ongen Vedat Hamuryudan Gulen Hatemi Source Type: research