The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease.
Authors: Korman B, Alejo R, Sudhakar D, Hinchcliff M, Agrawal R, Varga J, Marangoni RG PMID: 30183591 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical implications of peripheral new bone formation in psoriatic arthritis: a literature-based review.
Authors: Marchesoni A, Caporali R, Lubrano E Abstract While the destructive changes of peripheral articular damage of psoriatic arthritis (PsA) are extensively studied, the productive modifications have been somewhat neglected. This literature-based study focuses on the clinically relevant aspects of peripheral bone proliferation in PsA. New bone proliferation frequently occurs as juxta-articular and entheseal apposition in PsA patients but also in psoriatic patients without arthritis, the Psoriatic Arthritis Ratingen Score is the only radiographic method to evaluate peri-articular new bone formation, numerous ultr...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A prospective, longitudinal study evaluating the baseline six-minute walk test as an individual reference value in systemic sclerosis patients.
Authors: Vandecasteele E, Melsens K, De Keyser F, De Pauw M, Deschepper E, Decuman S, Piette Y, Thevissen K, Brusselle G, Smith V Abstract OBJECTIVES: Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are the leading causes of death in systemic sclerosis (SSc). Although the six-minute walk test (6MWT) is used for evaluating ILD and PAH, no data are available on the evolution of the six-minute walk distance (6MWD) in SSc patients without ILD and PAH and whether the baseline 6MWD could serve as individual reference value for the management of those who will develop PAH or ILD. METHODS: Pro...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Evaluation of extreme patient-reported outcome in early spondyloarthritis and its impact on the effect of TNF- α blockers treatment.
CONCLUSIONS: Although presence of extreme PRO in this early axSpA setting was not very frequent, patients with extreme PRO were more likely to receive a TNFb and less likely to maintain the treatment at 2 years. Further studies evaluating the specific impact of extreme PRO on TNFb treatment in axSpA are warranted. PMID: 30183594 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and safety of certolizumab pegol in combination with methotrexate in methotrexate-inadequate responder Chinese patients with active rheumatoid arthritis: 24-week results from a randomised, double-blind, placebo-controlled phase 3 study.
Authors: Bi L, Li Y, He L, Xu H, Jiang Z, Wang Y, Li X, Wei W, Gu J, Wang G, Zhang Z, Zhou B, Liu Y, Wu Z, Liu H, He D, Lv Z, Li Z, Zuo X, Dong L, Wu H, Zhang H, Chen H, Bao C, Zhang Z, Zhang M, Song H, Zheng Y, Jiang L, Liu X, Boehnlein M, Dunkel J, Shao J, Harris K, Li Z Abstract OBJECTIVES: To evaluate the efficacy and safety of certolizumab pegol (CZP) in combination with methotrexate (MTX) in Chinese patients with active rheumatoid arthritis (RA) and an inadequate response to MTX. METHODS: This 24-week, phase 3, double-blind, placebo-controlled study was conducted in 30 centres across China. A total of 430...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Epidemiological, pharmacological and sociodemographic characterisation of a population of 386 fibromyalgic patients referred to a tertiary pain centre in Italy.
Authors: Martini A, Schweiger V, Del Balzo G, Sartori G, Parolini M, Chinellato E, Sarzi-Puttini P, Polati E Abstract Fibromyalgia's prevalence in Italy is about 4%. Apart from widespread pain and the three main conditions related to fibromyalgia that are included in its diagnosis (fatigue, unrefreshing sleep and cognitive disorders disturbances), there are a number of minor symptoms that have been associated to fibromyalgia. The current study aimed to characterise fibromyalgic patients referring to a single tertiary pain centre not only for sociodemographic data, but also with special attention on pharmacological ...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tocilizumab and the risk of respiratory adverse events in patients with rheumatoid arthritis: a systematic review and meta-analysis of randomised controlled trials.
CONCLUSIONS: Our meta-analysis did not reveal an increase in the risk of non-infectious respiratory AEs in adult patients with RA who were treated with TCZ compared with other csDMARDs and bDMARDs in RCTs. PMID: 30183597 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Altered mRNA expression levels of vaspin and adiponectin in peripheral blood mononuclear cells of systemic lupus erythematosus patients.
This study aimed to evaluate the mRNA expression levels of vaspin, adiponectin and adrenomedullin in peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as well as their clinical associations. METHODS: A total of 46 SLE patients and 51 normal controls were recruited. The three adipokines expression levels in PBMCs from SLE patients were measured by qRT-PCR, and their associations with major clinical and laboratory parameters of SLE patients were also analysed. RESULTS: Compared with normal controls, vaspin expression level in PBMCs was significantly decreased (p
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

From VEDOSS to established systemic sclerosis diagnosis according to ACR/EULAR 2013 classification criteria: a French-Italian capillaroscopic survey.
CONCLUSIONS: We describe NC findings in VEDOSS patients, identifying those suggesting a progression into established disease. These findings must be regarded as possible predictive risk factor to develop SSc and can also be of relevance in the detection of those cases with a faster development. Thus NC seems to have a diagnostic and prognostic role in VEDOSS cases. PMID: 30183599 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Validation of the Italian version of proposed GRAPPA flare questionnaire for patients with psoriatic arthritis.
Authors: Scriffignano S, Perrotta FM, De Socio A, Altobelli A, Sessa P, Scrivo R, Valesini G, Lubrano E Abstract OBJECTIVES: The aim of the present study was to validate an Italian version of the GRAPPA flare instrument to identify patients with psoriatic arthritis (PsA) with a possible disease flare. METHODS: This was a cross-sectional study enrolling consecutively PsA patients classified with CASPAR criteria. Inclusion criteria were: age ≥18 years and stable treatment (at least six months of follow-up) with conventional synthetic or biological DMARDs. The flare questionnaire was administered at baseline an...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Crystallising the role of adrenocorticotrophic hormone in the management of acute gout: a review.
CONCLUSIONS: ACTH is a fast acting, efficacious and well-tolerated option for patients with acute gout when traditional therapies have failed or are contraindicated. However, large, carefully designed, randomised controlled trials are required to confirm these findings. PMID: 30183601 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rheum4U: Development and testing of a web-based tool for improving the quality of care for patients with rheumatoid arthritis.
CONCLUSIONS: Rheum4U highlights the benefits of a web-based tool for clinical care, quality improvement and research in the clinic and this study provides valuable information to inform full platform implementation. PMID: 30183602 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Determinants of health-related quality of life in a multinational systemic sclerosis inception cohort.
CONCLUSIONS: Our study provides estimates of HRQoL in a large inception SSc cohort and provides evidence that individual patient data analysis is valid in the INSYNC dataset. PMID: 30183603 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Associations between interleukin-10 gene polymorphisms and systemic lupus erythematosus risk: a meta-analysis with trial sequential analysis.
CONCLUSIONS: Our study suggests that the IL10-1082A/G polymorphism is a risk factor in systemic lupus erythematosus. A decreased risk of SLE in the IL10-819C/T and IL10-592C/A polymorphisms in subgroups was also observed, but further rigorously studies are needed to confirm these results. PMID: 30183604 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Impact of a lung ultrasound course for rheumatology specialists (IMPACT-2).
Authors: Gasho CJ, Torralba KD, Chooljian DM, Cohen A, Dinh VA Abstract OBJECTIVES: Lung ultrasound (LUS) plays an increasing role in diagnosis and monitoring of interstitial lung disease (ILD). Connective tissue disorders (CTD) frequently cause ILD, and often presents symptomatically after irreversible fibrosis has ensued. As point-of-care musculoskeletal ultrasound (US) is commonly utilised by rheumatologists, translating this US expertise towards LUS places the rheumatologist in a position to screen for ILD. However, a standardised curriculum for the rheumatology community is lacking. The aim of this study is to...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between non-dipper hypertension and vitamin D deficiency in women with systemic lupus erythematosus.
CONCLUSIONS: Vitamin D deficiency may contribute to the development of a non-dipper pattern in patients with SLE. PMID: 30183606 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Real-world experience with tofacitinib for treatment of rheumatoid arthritis.
Authors: Caporali R, Zavaglia D Abstract OBJECTIVES: Oral targeted synthetic disease-modifying anti-rheumatic drugs (DMARDs), including the Janus kinase inhibitors tofacitinib and baricitinib, are the latest addition to the therapeutic options for rheumatoid arthritis (RA). Tofacitinib 5 mg, twice daily, is approved for treatment, with or without methotrexate, of moderate to severe active RA in adults not adequately responding to, or not tolerating one or more DMARDs. In this narrative review we aimed to provide an overview of the real-world evidence for tofacitinib in RA. METHODS: The literature was reviewed u...
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antineutrophil cytoplasmic antibody and/or antiglomerular basement membrane antibody associated crescentic glomerulonephritis in combination with IgG4-related tubulointerstitial nephritis.
CONCLUSIONS: IgG4-TIN concurrent with anti-GBM glomerulonephritis and positivity in serum has more severe clinical features and a worse renal prognosis than IgG4-TIN coexistent with AVV. PMID: 30183608 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 7, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: Sj ögren's syndrome.
One year in review 2018: Sjögren's syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):14-26 Authors: Argyropoulou OD, Valentini E, Ferro F, Leone MC, Cafaro G, Bartoloni E, Baldini C Abstract Sjögren's syndrome is a complex and potentially disabling slow progressive, systemic disorder. During the last twelve months several original and important contributions have been published on the pathogenesis, diagnosis and therapy of the disease. This review, following the others of this series is aimed at summarising some of the most significant studies that have been recently published. Regar...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Autoantibodies to ox-LDL in Sj ögren's syndrome: are they atheroprotective?
CONCLUSIONS: These findings suggest that antibodies to ox-LDL, possibly resulting from B cell hyperactivity, might exert a protective role in the development of atherosclerosis among primary SS patients. PMID: 30156537 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Do I sound dry? Comparative voice analysis of primary Sj ögren's syndrome.
CONCLUSIONS: Patients with pSS had higher VHI score, which was associated with low quality of life and longer disease duration was associated with increased noise in pSS patients. The likelihood of voice problems should be addressed with pSS patients, and vocal hygiene education will be important in those patients. PMID: 30156538 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

How immunological profile drives clinical phenotype of primary Sj ögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).
How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project). Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):102-112 Authors: Brito-Zerón P, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Mandl T, Seror R, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Armagan B, Kruize AA, Kwok SK, Kvarnström M, Praprotnik S, Sène D, Bartoloni E, Solans R, Rischmueller M, Suzuki Y, Isenberg DA, Valim V, Wiland P, Nordmark G, Fraile G, Bootsma H, Nakamura T, Giacomelli R, ...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sj ögren's syndrome.
CONCLUSIONS: Overall, this study indicates that ACA-positive/and ACA-negative pSS patients apparently present a similar risk for lymphoproliferative complications as suggested indirectly by the analogies between the two groups observed at the histopathology level. PMID: 30156540 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Highlights of the 14th International Symposium in Sj ögren's Syndrome.
Highlights of the 14th International Symposium in Sjögren's Syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):3-13 Authors: Bombardieri M, Baldini C, Alevizos I, Akpek E, Baer AN PMID: 30156541 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Imaging in primary Sj ögren's syndrome: the 'obsolete and the new'.
Imaging in primary Sjögren's syndrome: the 'obsolete and the new'. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):215-221 Authors: Baldini C, Zabotti A, Filipovic N, Vukicevic A, Luciano N, Ferro F, Lorenzon M, De Vita S Abstract Primary Sjögren's syndrome (pSS) is a complex systemic autoimmune disease primarily characterised by a focal chronic inflammation of glandular parenchyma, with chronic and persistent involvement of major salivary gland remaining a key element of the disease. Indeed, classification criteria proposed for pSS have always included items for histological and/or imaging ...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Patient-reported change of sensibility and pain after parotid and labial gland biopsy applied for primary Sj ögren's syndrome diagnostics: one-year follow-up study.
CONCLUSIONS: Patient-reported post-operative change of sensibility and pain in the area of the parotid and labial gland biopsy are minor and comparable. Parotid and labial gland biopsies are diagnostic techniques well tolerated by patients suspected with pSS. PMID: 30156543 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Phenotyping Sj ögren's syndrome: towards a personalised management of the disease.
Phenotyping Sjögren's syndrome: towards a personalised management of the disease. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):198-209 Authors: Brito-Zerón P, Retamozo S, Ramos-Casals M Abstract Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The disease overwhelmingly affects women around 30-60 years old, and more than 95% of patients present with oral and/or ocular dryness, although they may also develop a wide number of organ-specific systemic manifestations. The variable presentation is often linked to the influence of multiple ...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Discrepancy between subjective symptoms, objective measures and disease activity indexes: the lesson of primary Sj ögren's syndrome.
Discrepancy between subjective symptoms, objective measures and disease activity indexes: the lesson of primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):210-214 Authors: Alunno A, Bartoloni E, Valentini V, La Paglia GMC, Valentini E, Leone MC, Marcucci E, Cafaro G, Bonifacio AF, Luccioli F, Gerli R Abstract Mucosal dryness is a key clinical feature in primary Sjögren's syndrome (pSS) and its assessment relies on both objective measurement of residual secretion and subjective symptoms reported by patients. However, while the objective assessment and grading of gland...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Severe, life-threatening phenotype of primary Sj ögren's syndrome: clinical characterisation and outcomes in 1580 patients (GEAS-SS Registry).
Severe, life-threatening phenotype of primary Sjögren's syndrome: clinical characterisation and outcomes in 1580 patients (GEAS-SS Registry). Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):121-129 Authors: Flores-Chávez A, Kostov B, Solans R, Fraile G, Maure B, Feijoo-Massó C, Rascón FJ, Pérez-Alvarez R, Zamora-Pasadas M, García-Pérez A, Lopez-Dupla M, Duarte-Millán MÁ, Ripoll M, Fonseca-Aizpuru E, Guisado-Vasco P, Pinilla B, de-la-Red G, Chamorro AJ, Morcillo C, Fanlo P, Soto-Cárdenas MJ, Retamozo S, Ramos-Casals M, Brito-Zerón P, GE...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Decrease in the ratio of polyreactive IgG titers with IgG concentration is associated with long-term complications of primary Sj ögren's syndrome.
Decrease in the ratio of polyreactive IgG titers with IgG concentration is associated with long-term complications of primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):239-240 Authors: Argyropoulou OD, Gunti S, Kapsogeorgou EK, Notkins AL, Tzioufas AG PMID: 30156547 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The evaluation of disease activity in Sj ögren's syndrome based on the degree of MALT involvement: glandular swelling and cryoglobulinaemia compared to ESSDAI in a cohort study.
CONCLUSIONS: The autoimmune and lymphoproliferative involvement of MALT is the biological substrate of pSS. If this involvement is heavier, as reflected by SG swelling and cryoglobulinaemia, disease activity may be considered higher, and the risk of lymphoma is increased. The current concept and evaluation of activity of pSS, based solely on the ESSDAI, needs revision. PMID: 30156548 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Artificial neural networks help to identify disease subsets and to predict lymphoma in primary Sj ögren's syndrome.
CONCLUSIONS: Our study has shed new light on the possibility of using novel tools to extract hidden, previously unknown and potentially useful information in complex diseases like pSS, facing the challenge of disease phenotyping as a prerequisite for discovering novel specific biomarkers and new therapeutic targets. PMID: 30156549 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of salivary gland histopathology in primary Sj ögren's syndrome: promises and pitfalls.
The role of salivary gland histopathology in primary Sjögren's syndrome: promises and pitfalls. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):222-233 Authors: Kroese FGM, Haacke EA, Bombardieri M Abstract The formation of lymphomononuclear cell infiltrates organising as periductal infiltrates in the salivary glands of patients with primary Sjögren's syndrome (pSS) is one of the hallmarks of the disease. Historically, the clinical role of salivary gland histopathology, most commonly performed on labial salivary gland biopsies, has been confined to the clinical classification and diagnosis o...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

14th International Symposium on Sj ögren's Syndrome.
14th International Symposium on Sjögren's Syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):241-255 Authors: Baer AN, Akpek EK, Alevizos I, 18-21 April 2018, Washington, DC, USA PMID: 30156551 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Poster presentations.
Authors: PMID: 30156552 [PubMed] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Severe cutaneous hand infection: Mycobacterium marinum in an immunosuppressed patient.
Authors: Argyropoulou OD, Zampeli E, Sipsas NV, Tzioufas AG, Moutsopoulos HM PMID: 30148427 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis?
CONCLUSIONS: Autoantibodies only partially contribute to risk-stratification and clinical subsetting in SSc. The current findings confirm that not all ATA-positive patients have worse prognosis and as such, additional biomarkers are needed to guide clinical follow-up in SSc. PMID: 30148428 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hyper-IgD syndrome in a patient with IgA immunodeficiency.
Authors: Smerla RG, Agrafiotou C, Fragoulis GE PMID: 30148429 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Intra-articular 2.5% polyacrylamide hydrogel for the treatment of knee osteoarthritis: an observational proof-of-concept cohort study.
Authors: Henriksen M, Overgaard A, Hartkopp A, Bliddal H Abstract OBJECTIVES: There is a drought of effective treatments of knee osteoarthritis (OA) and new therapies are needed. The present study has been conducted to establish an initial estimate of effectiveness of intra-articular (IA) injection of a proprietary 2.5% cross-linked polyacrylamide hydrogel (PAAG) for the treatment of knee OA symptoms and signs. METHODS: Patients with knee OA were invited into a prospective open-label cohort study. The patients received up to two IA injections of 3 ml of PAAG 1 month apart. The WOMAC questionnaire was used to es...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study.
CONCLUSIONS: Supervised exercise training did not impair disease status and seemed to be feasible, safe and effective in patients with IMNM. Moreover, exercise training increased aerobic capacity, muscle strength and function, suggesting that this could be a novel potential coadjuvant therapy in IMNM. PMID: 30148431 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A randomised, double-blind, placebo-controlled study assessing the efficacy of high doses of vitamin D on functional disability in patients with rheumatoid arthritis.
Authors: Soubrier M, Lambert C, Combe B, Gaudin P, Thierry T, Sibilia J, Dougados M, Dubost JJ Abstract OBJECTIVES: To evaluate the short-term efficacy of vitamin D (cholecalciferol) supplementation on functional disability in RA patients. METHODS: 1) Patients: RA (ACR 1987 revised criteria) in non-remission (DAS28>2.6) whose treatment was not expected to be changed over a 3-month period following inclusion and presenting with vitD deficits (serum 25OHD
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A combination model to predict relapse and successful conventional DMARDs de-escalation in rheumatoid arthritis patients with sustained clinical remission.
CONCLUSIONS: De-escalation therapy was associated with higher risk of relapse in RA patients with sustained clinical remission. A combination model of DAS28(CRP)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical and quality of life improvements with golimumab or infliximab in a real-life ankylosing spondylitis population: the QUO-VADIS study.
Authors: Van den Bosch F, Flipo RM, Braun J, Vastesaeger N, Kachroo S, Govoni M Abstract OBJECTIVES: The QUO VADIS study evaluated disease activity and health-related quality-of-life (HRQoL) in ankylosing spondylitis (AS) patients treated with golimumab (GLM) or infliximab (IFX, originator) during routine clinical care. METHODS: This prospective observational study followed biologics-naïve AS patients newly treated with GLM or IFX for 6 months. Disease activity (BASDAI, BASFI, ASAS, and ASDAS) and HRQoL improvement (≥5 points of SF-36 Physical Component Summary [PCS] score; PCS response) were measured. ...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Methotrexate did not improve endothelial function in rheumatoid arthritis: a study in rats with adjuvant-induced arthritis.
CONCLUSIONS: Despite a reduction of clinical and biological inflammation, methotrexate did not improve endothelial function in AIA rats. Overall data suggest that mechanisms other than the ED reduction are likely involved, and remain to be elucidated to better understand the cardiovascular benefits of methotrexate in rheumatoid arthritis. PMID: 30148435 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Secukinumab provides rapid and persistent relief in pain and fatigue symptoms in patients with ankylosing spondylitis irrespective of baseline C-reactive protein levels or prior tumour necrosis factor inhibitor therapy: 2-year data from the MEASURE 2 study.
Authors: Deodhar A, Conaghan PG, Kvien TK, Strand V, Sherif B, Porter B, Jugl SM, Gandhi KK, MEASURE 2 study group Abstract OBJECTIVES: To evaluate improvement in pain and fatigue in ankylosing spondylitis (AS) patients treated with secukinumab over 2 years (MEASURE 2 study). METHODS: Patients with active AS were randomised to receive secukinumab 150 mg, 75 mg, or placebo weekly until Week 4, and every 4 weeks thereafter. This post hoc analysis included assessment of spinal and nocturnal back pain, FACIT-Fatigue, and association between pain and either FACIT-Fatigue or ASQoL item 5 (sleep quality) for the appro...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Can switching to abatacept therapy in patients with rheumatoid arthritis on background methotrexate reverse TNF-inhibitor-induced antinuclear autoantibody/double-stranded DNA autoantibody conversion? An analysis of the AMPLE and ATTEST trials.
CONCLUSIONS: ANA/anti-dsDNA seroconversion was more frequent with TNFi than abatacept therapy; TNFi-associated seroconversion decreased after switching from TNFi to abatacept. PMID: 30148437 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical features and risk of recurrence of acute calcium pyrophosphate crystal arthritis.
This study compared the clinical features and recurrence rates of both conditions. METHODS: In this retrospective study, we reviewed 106 patients with acute CPP crystal arthritis (based on the presence of CPP crystals and/or chondrocalcinosis) and 173 patients with gout (based on the presence of monosodium urate crystals). We analysed clinical variables and compared them between the two conditions. We identified factors associated with the recurrence of acute CPP crystal arthritis. RESULTS: Patients with acute CPP crystal arthritis were older (76.5 vs. 62 years, p
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Normal sonoanatomy of small joints in healthy children: changes in cartilage and vascularisation according to age and gender.
Authors: Jousse-Joulin S, Cangemi C, Alavi Z, Gerard S, Nonent M, Bressollette L, De Parscau L, Devauchelle-Pensec V, Saraux A Abstract OBJECTIVES: The metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints may be involved in juvenile idiopathic arthritis. Our goal was to describe their normal sonoanatomy in healthy children, according to age and gender. METHODS: We studied 41 consecutive healthy children (20 girls, 21 boys; age 2-15 years) divided into four age groups: 2-4 years (n=9), 5-7 years (n=11), 8-12 years (n=12), and 13-15 years (n=9). Longitudinal ultrasound axis of the MCP and MTP joints wer...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Risk of hospitalisation for serious bacterial infections in patients with rheumatoid arthritis treated with biologics. Analysis from the RECord linkage On Rheumatic Disease study of the Italian Society for Rheumatology.
CONCLUSIONS: In RA patients treated with bDMARDs, abatacept was associated with the lowest risk of infections; overall risk was mitigated by concomitant methotrexate and increased by glucocorticoids in a dose-dependent manner. PMID: 30148440 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tocilizumab modulates serum levels of adiponectin and chemerin in patients with rheumatoid arthritis: potential cardiovascular protective role of IL-6 inhibition.
CONCLUSIONS: TCZ is able to regulate serum levels of chemerin and adiponectin in RA patients, independently of the disease treatment response, which contributes to explain the CV safety of TCZ. PMID: 30148441 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research