High prevalence of small intestinal bacterial overgrowth (SIBO) in spondylarthropathy.
Authors: Laroche JM, Kapel N, Benahmed N, Claudepierre P, Chevalier X, Barbot-Trystram L PMID: 33427609 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

TNF- α inhibitors reduce inflammation-induced concentric remodelling, but not diastolic dysfunction in collagen-induced arthritis.
TNF-α inhibitors reduce inflammation-induced concentric remodelling, but not diastolic dysfunction in collagen-induced arthritis. Clin Exp Rheumatol. 2021 Jan 11; Authors: Le Roux R, Mokotedi L, Fourie S, Manilall A, Gunter S, Millen AME Abstract OBJECTIVES: To determine biologic disease-modifying anti-rheumatic drug effects on inflammation-induced cardiac geometry and function changes. METHODS: Male and female Sprague-Dawley rats (n=92) were divided into four groups: control group, collagen-induced arthritis (CIA) group, anti-TNF-α group and anti-IL-6 group. Inflammation was induced by...
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence and clinical association with acro-osteolysis in early systemic sclerosis.
CONCLUSIONS: Acro-osteolysis was common in SSc at the early onset of disease. While the presence of anti-topo I, hand deformity and esophageal involvement were strongly associated with acro-osteolysis, oedematous skin was the protective factor for acro-osteolysis. PMID: 33427611 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Anakinra desensitisation in patients with cryopyrin-associated periodic syndromes.
We describe our experience with anakinra desensitisation in two cases with CAPS who had injection-site related reactions. We also propose a 34-day outpatient desensitisation protocol. PMID: 33427612 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Secukinumab real world drug retention compared to TNF-alpha inhibitors in psoriatic arthritis.
CONCLUSIONS: This multicentre real-world study demonstrated that secukinumab had a drug retention comparable to TNFi. Secukinumab had a better drug retention than TNFi among biologic-experienced patients. IL-17 inhibition is an effective mechanism of action to treat PsA in real life. PMID: 33427613 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Disease activity in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the utility of the SPARCC MRI scoring system for assessment of axial spine involvement.
Authors: Gu Z, Li C, Xu W, Xiang Y, Gao C, Wu N, Zhao Y, Cao Y, Zhang W, Zhang W Abstract OBJECTIVES: The aim of this study is to investigate the relationship between spinal MRI findings with disease activity and other clinical and serological parameters, and to determine the importance of MRI scoring system in evaluating disease activity of SAPHO syndrome. METHODS: Thirty patients with SAPHO syndrome underwent clinical, laboratory and MRI evaluation at baseline, 3 months, 6 months and 1 year. Magnetic resonance images were analysed using modified Spondyloarthritis Research Consortium of Canada (SPARCC) scoring...
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Non-medical switching from reference to biosimilar etanercept - no evidence for nocebo effect: a retrospective analysis of real-life data.
CONCLUSIONS: Systematic switch from reference to biosimilar etanercept was not associated with changes in disease activity or function in. This was independent of information on the switch transmitted to the patients. PMID: 33427615 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Retinal detachment as first manifestation of systemic lupus erythematosus.
Authors: Iaccheri B, Cerquaglia A, Bartoloni E, Cagini C, Fiore T PMID: 33427616 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Postural control and disability in patients with early rheumatoid arthritis.
Authors: De Lorenzis E, Crudo F, Fedele AL, Fiorita A, Bruno D, Paludetti G, Alivernini S, Giraldi L, Picciotti PM, Zoli A, Cadoni G Abstract OBJECTIVES: Rheumatoid arthritis (RA) may affect the postural control through abnormal sensory inputs and impaired motor responses. Sensory Organization Test (SOT) objectively evaluates contribution of different sensorial afferences in postural control. The aim of the study is to assess mechanisms of postural instability and their relations with disability and disease characteristics in an early RA(ERA) cohort. METHODS: The equilibrium scores were assessed in 30 ERA patie...
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Post-hoc analysis of pegloticase pivotal trials in chronic refractory gout: relationship between fluctuations in plasma urate levels and acute flares.
Authors: Mandell BF, Fields TR, Edwards NL, Yeo AE, Lipsky PE Abstract OBJECTIVES: To determine factors associated with gout flares in subjects treated with pegloticase. METHODS: Gout flares from two randomised controlled trials comparing pegloticase (8 mg every 2 weeks [q2] or monthly [q4]) versus placebo were analysed. Responders had persistent urate lowering (
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

NKG2D ligands in inflammatory joint diseases: analysis in human samples and mouse models.
CONCLUSIONS: sMICA quantification could be an interesting biomarker to identify acute inflammation in RA patients in whom classical markers (i.e. anti-citrullinated protein antibodies, ACPA) are undetectable. PMID: 33427619 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Quality of life and therapeutic management of axial spondyloarthritis patients in Italy: a 12-month prospective observational study.
CONCLUSIONS: We found clinical and HRQoL improvement over 1 year in a large, real-world population of nr-axSpA and AS patients treated with bDMARDs or conventional synthetic DMARDs. PMID: 33427620 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis.
CONCLUSIONS: Autoantibody against PGLYRP-2 was identified as a promising biomarker in RA, especially in early and seronegative patients. PMID: 33427621 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Anti-tumour necrosis factor-alpha response associated with combined CD226 and HLA-DRB1*0404 haplotype in rheumatoid arthritis.
CONCLUSIONS: This study has investigated individual allele associations with reductions in DAS28 across a range of anti-TNFα treatments. A combined predictive model indicates that patients with the HLA-DRB1*0404 allele and without the CD226 rs763361 polymorphism exhibit the largest reduction in DAS28 after anti-TNF-α treatment. PMID: 33427622 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Disease activity at the entheses and joints are correlated in psoriatic arthritis when explored with ultrasound.
Authors: Ayan G, Tinazzi I, Bakirci S, Gazel U, Solmaz D, Kalyoncu U, Aydin SZ Abstract OBJECTIVES: The aim of this study is to explore the link between the severity of the joint and entheses involvement in psoriatic arthritis (PsA) using musculoskeletal ultrasound (US). METHODS: PsA patients from two centres in the Psoriatic Arthritis International Database (PsArt-ID) (n=126) underwent an ultrasound assessment of 46 joints and 12 large entheses. The correlation between joint and enthesitis scores on the US was analysed, in addition to the clinical indices versus the US. RESULTS: Grey-scale (GS) synovitis s...
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Myeloid neoplasms and autoimmune diseases: markers of association.
CONCLUSIONS: A possible common genetic predisposition, the inflammatory bone marrow microenvironment and the activation of theJAK/STAT pathway could be considered as responsible for the observed association between MPNs and ADs. PMID: 33427624 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Dual-energy computed tomography for the detection of sacroiliac joints bone marrow oedema in patients with axial spondyloarthritis.
CONCLUSIONS: DECT VNCa images had good diagnostic performance in the evaluation of the extent of BME in patients with sacroiliitis associated with axial SpA. PMID: 33427625 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Real-world effectiveness of tofacitinib in patients with rheumatoid arthritis: a prospective observational study.
Authors: Shouval A, Lidar M, Reitblat T, Zisman D, Balbir-Gurman A, Mashiach T, Almog R, Elkayam O Abstract OBJECTIVES: Tofacitinib is an approved treatment for rheumatoid arthritis (RA), but data on its use in the "real-world" are limited. We sought to analyse tofacitinib drug survival in the Israeli registry and compare it to other biologic agents. METHODS: We included RA patients treated with tofacitinib, etanercept, golimumab, tocilizumab, or abatacept between 2010-2019. The primary endpoint was event-free survival (EFS), defined as the time from treatment initiation to a treatment failure event f...
Source: Clinical and Experimental Rheumatology - January 13, 2021 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Histone deacetylase 1 is increased in rheumatoid arthritis synovium and promotes synovial cell hyperplasia and synovial inflammation in the collagen-induced arthritis mouse model via the microRNA-124-dependent MARCKS-JAK/STAT axis.
CONCLUSIONS: To sum up, silencing HDAC1 mitigates synovial cell hyperplasia and synovial inflammation in mice with CIA by elevating miR-124 and MARCKS expression, thus highlighting a promising competitive new target for RA treatment. PMID: 33337986 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Gender differences on psychological factors in fibromyalgia: a systematic review on male's experience.
CONCLUSIONS: FM male patients consider their masculine identity as inefficiently re-negotiated after symptoms' onset. FM males tend to endure pain for longer periods of time than females before seeking for treatment; bodily symptoms are prevalent with a compromised exploration of feelings about FM. Unfortunately, there is still paucity of evidence on clinical characterisation and treatment options when FM occurs in males. Moreover, no studies addressed the issue of the psychopharmacological/non-pharmacological management of males with FM and comorbid psychiatric syndromes. PMID: 33337987 [PubMed - as supplied by publis...
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Evaluating renal outcome of ANCA-associated renal vasculitis: comparative study of two histopathological scoring systems.
Authors: An XN, Wei ZN, Yao XY, Xu J, Qian WT, Pan XX, Shen PY, Shi H, Zhang W, Chen XN, Chen N, Chen YX Abstract OBJECTIVES: Renal risk score (RRS) and chronicity score (CS) are both newly proposed tools to predict end stage renal disease (ESRD) which could be applicable in antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis patients. Their predictive value has not been fully studied and compared. METHODS: 252 patients with newly biopsy-proven ANCA-associated renal vasculitis were retrospectively studied at the Department of Nephrology, Ruijin Hospital, China. Patients were evaluated with RR...
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

18-FDG PET for large vessel vasculitis diagnosis and follow-up.
CONCLUSIONS: The results confirm the role of 18-FDG PET as a powerful tool in the evaluation of LVV, both at the time of diagnosis and during monitoring. Furthermore, the data confirm that GCA and TAK are part of the same disease spectrum. PMID: 33337989 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Naturalistic 6-month antidepressants follow-up in patients with fibromyalgia: impact on somatic and mood spectrum symptoms.
CONCLUSIONS: Our results corroborate previous findings on the role of antidepressant drugs in the management not only of MDD symptoms, but also of the painful component of FM. FM patients should be investigated for Mood Spectrum symptomatology considering its prominent role on the manifestations of the disorder and treatment outcome. PMID: 33337990 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association of anti-RNA polymerase III antibody with silicone breast implants rupture in a multicentre series of Italian patients with systemic sclerosis.
CONCLUSIONS: In this study we demonstrated a link between SBI rupture and induction of anti-RNAP3+ SSc; further studies are needed to better define the characteristics of this syndrome and the possible effects of SBI removal and immunosuppressive treatment. PMID: 33337991 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Effectiveness and safety of baricitinib in rheumatoid arthritis: a monocentric, longitudinal, real-life experience.
We report the first real-life experience with baricitinib in a monocentric cohort of unselected RA patients. METHODS: We enrolled consecutive RA patients starting baricitinib. At baseline and after 4, 12, 24 and 48 weeks we assessed the disease activity by composite indices (SDAI, CDAI and DAS28CRP) and ultrasonography, and we recorded any adverse events. The primary endpoint was the percentage of patients achieving SDAI remission at week 4. RESULTS: We enrolled 59 patients [(F:M = 50:9, median age 58.1 years (IQR 12.8), median disease duration 144 (IQR 150) months] treated with baricitinib in combination with a cs...
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Adult Autism Subthreshold spectrum correlates to Post-traumatic Stress Disorder spectrum in patients with fibromyalgia.
CONCLUSIONS: These results highlight the clinical relevance of autistic traits in FM patients with PTSD. In this regard, we may claim a potential role of abnormal processing of sensory input and deficits in non-verbal communication in explaining this association. PMID: 33337993 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Occurrence and predictive factors of high blood pressure, type 2 diabetes, and metabolic syndrome in rheumatoid arthritis: findings from a 3-year, multicentre, prospective, observational study.
CONCLUSIONS: An increased incidence of HBP, T2D, and MetS was observed in assessed participants, prospectively followed-up. Furthermore, the analysis of predictive factors suggested that the rheumatoid pro-inflammatory process could increase the occurrence of these comorbidities. Conversely, metabolic and cardiovascular benefits of maintaining remission as well as of therapy with HCQ were reported. PMID: 33337994 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rheumatoid factor and anti-citrullinated peptide antibodies in the general population: hepatitis B and C virus association and 15-year-risk of rheumatoid arthritis.
CONCLUSIONS: Our data in a large cohort from an unselected general population confirm a higher risk of RA development associated with ACPA compared to RF. HBV exposure correlates with RF but not with ACPA positivity. PMID: 33337995 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Genetic heterogeneity in Chinese children with systemic lupus erythematosus.
CONCLUSIONS: We revealed a significant fraction of monogenic SLE aetiologies using WES (12/52, 23.1%). WES should perform in patients with very early onset SLE (14), family history of autoimmune disease, primary immunodeficiency disease and renal and haematological involvement. PMID: 33337996 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

An unusual presentation of giant cell arteritis in a middle-aged woman.
Authors: Zampeli E, Anagnostopoulos C, Moutsopoulos HM PMID: 33337997 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Galectin-3-binding protein is a novel predictor of venous thromboembolism in systemic lupus erythematosus.
CONCLUSIONS: Our study identifies serum G3BP as a novel predictor of VTE in SLE. Further studies are needed to understand the role of G3BP in VTE and translate this into clinical practice. PMID: 33337998 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Validation of the EULAR/ACR 2017 idiopathic inflammatory myopathy classification criteria in juvenile dermatomyositis patients.
CONCLUSIONS: The new EULAR/ACR criteria performed favourably in our JDM cohort especially with the probability cut-off of>62%. PMID: 33337999 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Infection versus cardiovascular disease as leading causes of hospitalisations and associated mortality in vasculitis in the U.S.: a national study.
CONCLUSIONS: Infections replaced cardio-pulmonary disease among the top 5 causes for non-primary vasculitis hospitalisations and associated in-hospital mortality in people with vasculitis over time. Studies should examine modifiable factors associated with infection in vasculitis and design interventions to reduce this burden. PMID: 33338000 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and safety of baricitinib in 446 patients with rheumatoid arthritis: a real-life multicentre study.
CONCLUSIONS: Real-life data confirm the efficacy and safety profiles of baricitinib in patients with RA and provide evidence that drug survival is higher in bDMARDs-naïve and seropositive patients. PMID: 33338001 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Good pain, bad pain: illness perception and physician attitudes towards rheumatoid arthritis and fibromyalgia patients.
Authors: Aloush V, Niv D, Ablin JN, Yaish I, Elkayam O, Elkana O Abstract OBJECTIVES: Rheumatoid arthritis (RA) and fibromyalgia syndrome (FM) are common diagnoses encountered in rheumatology practice, but do not enjoy the same status. We aimed to examine physician's illness perceptions regarding these two rheumatologic disorders and to evaluate how they correlate with their relationship with these patients. METHODS: Forty-five rheumatologists were enrolled in the study. Demographic data were registered. Measures collected included the Brief Illness Perception Questionnaire (BIPQ) and the Difficult Doctor- Pati...
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A new focus on thyrosine kinases inhibitors in eosinophilic granulomatosis with polyangiitis.
Authors: Triggianese P, D'Antonio A, Conigliaro P, Buccisano F, Fonti GL, Chimenti MS, Perricone R PMID: 33338003 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Assessment of glucocorticoid tapering in large vessel and anti-neutrophil cytoplasmic antibody-associated vasculitides.
Authors: Mendel A, Ennis D, Carette S, Pagnoux C Abstract OBJECTIVES: Glucocorticoids (GC) remain integral to large vessel vasculitis (LVV) and ANCA-associated vasculitis (AAV) treatment. We aimed to assess real-world GC tapering trajectories among patients referred for LVV or AAV and identify factors associated with 'delayed' tapering. METHODS: Patients first assessed at a vasculitis clinic July 2017-August 2019 for LVV or AAV and taking GC were included. Delayed tapering was defined as prednisone>10 mg above target based on tapering recommendations (2010 British Society of Rheumatology Guidelines for Giant...
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Incidence of COVID-19 in an Italian cohort of patients with systemic lupus erythematosus: an observational survey.
Authors: Fasano S, Ciccia F PMID: 33338005 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Methotrexate in Italian patients wiTh Rheumatoid Arthritis (MITRA study): an observational study about the use of methotrexate in early RA patients and the adherence to the EULAR 2013 recommendations. A project of the Italian Society for Rheumatology.
CONCLUSIONS: Diagnostic delay in RA patients continues to be longer than expected. The choice of low disease activity as a target is still very frequent and tight control does not seem to be based on disease activity. This paper offers a realistic and detailed picture of the clinical practice among Italian rheumatologists. PMID: 33338006 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Could the increasing concerns regarding the post-COVID-19 symptoms cause Kawasaki disease to be under-diagnosed?
Authors: Haslak F, Karagozlu F, Yildiz M, Adrovic A, Dedeoglu R, Kasapcopur O PMID: 33338007 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between mortality and cytomegalovirus reactivation during remission induction therapy in patients with rheumatic diseases.
Authors: Ota Y, Kaneko Y, Takeuchi T Abstract OBJECTIVES: To elucidate the characteristics of patients with rheumatic diseases with cytomegalovirus (CMV) reactivation. METHODS: In our study, we consecutively reviewed patients with rheumatic diseases who received remission induction therapy in our institution from January 2012 to March 2016 and enrolled the patients who were evaluated about CMV infection. CMV reactivation was characterised by the detection of polymorphonuclear leukocytes with CMV pp65. The characteristics and clinical courses of the patients with CMV reactivation were compared to those without C...
Source: Clinical and Experimental Rheumatology - December 19, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The possession of exon 2 or exon 3 variants in the MEFV gene promotes inflammasome activation in Japanese patients with familial Mediterranean fever with a heterozygous exon 10 mutation.
Authors: Endo Y, Koga T, Hara K, Furukawa K, Agematsu K, Yachie A, Masumoto J, Migita K, Kawakami A Abstract OBJECTIVES: The modification and pathogenesis of MEFV exon 2 or 3 variants in familial Mediterranean fever (FMF) remains unclear. We compared the clinical and laboratory characteristics between the coexistence and noncoexistence of MEFV exon 2 or 3 variants in patients with FMF that had a heterozygous MEFV exon 10 mutation. METHODS: We excluded patients with FMF that had two MEFV exon 10 mutations in one or more alleles and/or MEFV mutations in exons other than in exons 2, 3, or 10. Finally, we reviewed ...
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Left ventricular pseudoaneurysm revealing a Beh çet's disease: a case report.
Left ventricular pseudoaneurysm revealing a Behçet's disease: a case report. Clin Exp Rheumatol. 2020 Sep-Oct;38 Suppl 127(5):127-128 Authors: Lapébie FX, Robin G, Adoue D, Bura-Rivière A, Marcheix B PMID: 33331266 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Is the country of living important in the phenotypic expression of E148Q mutation? The Armenian experience.
Authors: Atoyan S, Hayrapetyan H, Yeghiazaryan A, Ben-Chetrit E, Sarkisian T PMID: 33331267 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Apremilast in refractory orogenital ulcers and other manifestations of Beh çet's disease. A national multicentre study of 51 cases in clinical practice.
CONCLUSIONS: APR yielded a rapid and maintained improvement of refractory mucocutaneous ulcers of BD, even in patients refractory to several systemic drugs including biologic therapy. PMID: 33331268 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

First report of MEFV gene duplication in a patient with familial Mediterranean fever.
Authors: Mechin D, Durinikova A, Boursier G, André M, Touitou I, Sarrabay G PMID: 33331269 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Alteration of oral flora in Mongolian patients with Beh çet's disease: a multicentre study.
CONCLUSIONS: The reduced proportions of the S24-7 family and symbiotic Akkermansia species may be key phenomena in the oral flora of patients with BD. PMID: 33331270 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2020: Beh çet's syndrome.
One year in review 2020: Behçet's syndrome. Clin Exp Rheumatol. 2020 Sep-Oct;38 Suppl 127(5):3-10 Authors: Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V Abstract Behçet's syndrome is a variable vessel vasculitis with multi-system involvement that shows important heterogeneity among patients regarding demographic features, organ manifestations, frequency and severity of relapses, disease course, response to treatment and prognosis. This heterogeneity has made it difficult to interpret and compare the results of studies, to standardise disease assessment and to develop management s...
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Attacks of TNF-receptor associated periodic syndrome are associated with higher inflammatory markers than familial Mediterranean fever.
Authors: Ducharme-Bénard S, Steichen O, Savey L, Hentgen V, Aouba A, Grateau G, Georgin-Lavialle S PMID: 33331272 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia and is modulated by hyperbaric oxygen therapy.
Authors: Guggino G, Schinocca C, Lo Pizzo M, Di Liberto D, Garbo D, Raimondo S, Alessandro R, Brighina F, Ruscitti P, Giacomelli R, Sireci G, Triolo G, Casale R, Sarzi-Puttini P, Dieli F PMID: 33275092 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - December 5, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research