Angiogenic T cells in primary Sj ögren's syndrome: a double-edged sword?
CONCLUSIONS: In pSS, Tang cells are expanded in peripheral blood and infiltrate MSG. Tang may be novel actors in pSS-related endothelial dysfunction and glandular neo-angiogenesis and inflammation. PMID: 30336792 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 20, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Subclinical but significant liver fibrosis in patients with ANCA-associated vasculitis.
Authors: Lee SW, Kim DY, Ahn SH, Park YB, Han KH, Park JY Abstract OBJECTIVES: We evaluated the laboratory and radiological data on liver and investigate liver fibrosis induced by hepatic manifestation of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) using the aspartate aminotransferase to platelet ratio index (APRI) and an index of fibrosis (FIB-4) in 136 immunosuppressive drug-naïve patients. METHODS: We retrospectively reviewed the medical records of 136 patients with AAV without chronic liver diseases or autoimmune diseases. We collected the laboratory and imaging results. We assessed...
Source: Clinical and Experimental Rheumatology - October 17, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Categorisation of disease severity states in fibromyalgia: a first step to support decision-making in health care policy.
CONCLUSIONS: The FIQR and FAS cut-off points for remission, mild, moderate and high disease severity are valid measures which can be easily applied in daily clinical practice. PMID: 30325304 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 17, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Use of contrast-enhanced magnetic resonance imaging of the pelvis to describe changes at different anatomic sites which are potentially specific for polymyalgia rheumatica.
CONCLUSIONS: The uniformity of the observed pelvic inflammatory pattern detected by contrast-enhanced MRI in PMR patients suggests that it may become relevant for diagnostic purposes. The bilateral involvement of at least 4 extracapsular sites (including the origins of proximal rectus femoris or adductorial muscles) appears to be characteristic of PMR. PMID: 30296970 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Imaging of axial spondyloarthritis. New aspects and differential diagnoses.
Authors: Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M Abstract Axial spondyloarthritis (axSpA) is a chronic rheumatic disease characterised by inflammatory back pain and several other disease manifestations and comorbidities. The 2009 ASAS classification criteria differentiate between the classical ankylosing spondylitis or radiographic axSpA and non-radiographic axSpA based on the presence or absence of definite radiographic changes in the sacroiliac joints. Importantly, back pain in patients with axSpA may well have reasons other than axial inflammation or new bone formation. There are several important di...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Imaging of joints in systemic lupus erythematosus.
Authors: Tani C, Carli L, Stagnaro C, Elefante E, Signorini V, Balestri F, Delle Sedie A, Mosca M Abstract Musculoskeletal symptoms are among the most common manifestations in patients with systemic lupus erythematosus (SLE), being reported in up to 95% of patients; joint and tendon involvement can range from arthralgia to severe deforming arthropathy; while myositis a rare manifestation, comorbid fibromyalgia is reported in up to 40% of SLE patients. All these manifestations have a significant impact on the patients' quality of life, possibly leading to disability and functional impairment in daily living activiti...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Imaging detected tenosynovitis of metacarpophalangeal and wrist joints: an increasingly recognised characteristic of rheumatoid arthritis.
Authors: Niemantsverdriet E, van der Helm-van Mil AHM Abstract Tenosynovitis is traditionally recognised at physical examination in patients with inflammatory rheumatic diseases, such as, e.g. psoriatic arthritis and (longstanding) rheumatoid arthritis (RA). The increasing use of sensitive imaging techniques (ultrasound, magnetic resonance imaging (MRI)) has recently revealed that subclinical tenosynovitis is prevalent in early RA and in patients in different phases of RA development (asymptomatic state, arthralgia, early arthritis). In this review, the recent findings on MRI-detected tenosynovitis and associations...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Update on magnetic resonance imaging and ultrasound in rheumatoid arthritis.
Authors: Baker JF, Conaghan PG, Gandjbakhch F Abstract Rheumatoid arthritis (RA) disease activity often remains difficult to assess and quantify accurately. As a result, numerous measures using various techniques to estimate clinical activity have been developed for clinical research and care. More objective imaging biomarkers for early detection and accurate, quantitative measurement of the disease burden are therefore of interest both for clinical use and for investigational studies. Two widely studied imaging biomarkers are magnetic resonance imaging (MRI) and ultrasound (US), imaging tests that are increasingly...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The use of ultrasound in the management of large-vessel vasculitis: an evolving concept.
Authors: Monti S, Águeda AF, Luqmani R Abstract Imaging is increasingly recognised as an essential element in the management of several rheumatologic conditions. Ultrasound is in widespread use as a safe, reproducible, and directly interpretable method for diagnosis and evaluation of arthritis and increasingly of large-vessel vasculitis (LVV). Indeed, the diagnosis and management of LVV are being transformed through the use of imaging. Increasing and more standardised evidence is being produced on the role of colour duplex sonography in the management of LVV. Nonetheless, some controversies and unresolved is...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

MRI in imaging of rheumatic diseases: an overview for clinicians.
This article briefly reviews the technical principle of magnetic resonance and discusses advantages and disadvantages of the technique, with particular attention to rheumatologic imaging. New information is summarised concerning the use of contrast media, dynamic, contrast-enhanced MRI, diffusion-weighted imaging, cartilage imaging and whole-body MRI. PMID: 30296976 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Enthesitis detection by ultrasound: where are we now?
Authors: D'Agostino MA Abstract Over the last 25 years, ultrasound has been used to evaluate involvement at the entheses in spondyloarthritis (SpA) and psoriatic arthritis (PsA). Several studies have been reported indicating its value in detecting active inflammation at entheseal sites using both gray scale and Doppler findings. This review explores the recent literature and appraises the current knowledge and the unmet needs of enthesitis detection by ultrasound in the management of both SpA and PsA. PMID: 30296977 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The peripheral nerves: update on ultrasound and magnetic resonance imaging.
This article focuses on imaging of peripheral nerves by magnetic resonance imaging (MRI) and high-resolution ultrasound (US). The anatomic basis of the peripheral nerve image, common pathologies and clinical value of US and MRI imaging of peripheral nerves are reviewed. PMID: 30296978 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Update on imaging in gout: contrasting and comparing the role of dual-energy computed tomography to traditional diagnostic and monitoring techniques.
Authors: Bayat S, Baraf HSB, Rech J Abstract In this systematic literature review, we update imaging modalities in gout, with a focus on newer technologies, particularly Dual-energy computed tomography (DECT). Conventional radiography (CR), ultrasonography (US), magnetic resonance imaging (MRI), computed tomography (CT) and dual-energy CT (DECT) have been used to evaluate different stages and clinical manifestations of gout and hyperuricaemia. We compare and contrast these modalities across the spectrum of this disease and of clinical scenarios and objectives (1). PMID: 30296979 [PubMed - in process] (Source: C...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Update on imaging in rheumatic diseases.
Authors: Baraliakos X, Braun J, Conaghan PG, Østergaard M, Pincus T PMID: 30296980 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Update on imaging in rheumatic diseases: cartilage.
Authors: Sewerin P, Schleich C, Vordenbäumen S, Ostendorf B Abstract In recent years, the role of articular cartilage for understanding pathogenesis as well as for clinical research has become increasingly important. Whereas previously cartilage could only be assessed invasively, various imaging procedures are available for its evaluation now. Although still widely used, conventional radiography bears significant limitations since it assesses cartilage indirectly by joint space width. Today, the cartilage thickness and structure can be reliably evaluated using ultrasound, although the molecular structure canno...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of imaging in evaluating patients with idiopathic inflammatory myopathies.
CONCLUSIONS: MRI is currently the most useful method capable of demonstrating both inflammatory and post-inflammatory changes in the muscles and surrounding soft tissue. Several studies have documented potential usefulness of other imaging techniques, such as ultrasonography, positron emission tomography, scintigraphy, and dual-energy x-ray absorptiometry. PMID: 30296982 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasonography in gout: utility in diagnosis and monitoring.
This report evaluates the current literature on the use of ultrasonography for diagnosing and monitoring gout. PMID: 30296983 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Recent advances in research imaging of osteoarthritis with focus on MRI, ultrasound and hybrid imaging.
Authors: Hayashi D, Roemer FW, Guermazi A Abstract For imaging of osteoarthritis (OA), MRI plays a major role in the research setting, with compositional MRI techniques becoming increasingly more important thanks to their capacity to assess 'premorphologic' biochemical compositional changes of articular and periarticular tissues. Although radiography remains the primary imaging modality in OA clinical trials, known limitations for visualisation of OA features significantly limits the utility of radiography both clinically and in the research arena. Compositional MRI techniques can potentially supplement routine cli...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Magnetic resonance imaging and magnetic resonance angiography in large-vessel vasculitides.
Authors: Guggenberger KV, Bley TA Abstract The role of imaging in diagnosis and monitoring of vasculitides has steadily become more important during the last years. As a result of the technological progress, its low invasiveness and its relatively good diagnostic reliability, magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) are increasingly used in the assessment of vasculitic changes of extra- and intra-cranial arteries. The aim of this review is to outline the significance of different imaging modalities, particularly the significance of MRI/MRA, in the context of large-vessel vasculitide...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of cardiovascular magnetic resonance imaging in rheumatic heart disease.
Authors: Baeßler B, Emrich T Abstract Cardiovascular involvement is a well-known feature of inflammatory rheumatic diseases, although often clinically silent, so early cardiovascular involvement may remain unrecognised. Thus, increased awareness and improved insights into the pathomechanisms of heart disease in the context of inflammatory rheumatic disease has led to an emerging role of cardiovascular magnetic resonance (CMR) as an accurate and non-invasive diagnostic test for detection of early (as well as late) cardiovascular involvement in inflammatory rheumatic disease. The present article will review the...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Overview of musculoskeletal ultrasound for the clinical rheumatologist.
Authors: Hassan S Abstract Within the realm of rheumatology, the field of musculoskeletal ultrasound (MSUS) has grown exponentially over the last few decades. This review, aimed at the clinical rheumatologist, provides a basic overview of the principles of image generation and the commonly used clinical applications of MSUS, while also highlighting its advantages and limitations. In particular, the role of MSUS in the assessment of early and established rheumatoid arthritis, crystalline disease, the spondyloarthropathies and Sjögren's disease is discussed in more detail and by reviewing the pertinent literatur...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Imaging in peripheral and axial psoriatic arthritis: contributions to diagnosis, follow-up, prognosis and knowledge of pathogenesis.
This article provides an overview of current knowledge of different imaging methods in PsA, including current and possible future use in diagnosis, prognosis and clinical management, value in understanding pathogenesis, and latest activities to establish responsive imaging outcome measures. Much research remains to be performed concerning imaging in PsA, particularly on its optimal use in routine clinical care, the clinical consequences of imaging-detected subclinical disease, and specific and sensitive PsA imaging outcome measures. PMID: 30296988 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of 18F-FDG positron emission tomography for the diagnosis of vasculitides.
Authors: Braun J, Baraliakos X, Fruth M Abstract Large-vessel vasculitis is the most common form of primary vasculitis comprising cranial and large-vessel giant cell arteritis, Takayasu's arteritis and idiopathic aortitis. Prompt diagnosis and treatment of large-vessel vasculitis are important to prevent potentially serious emergencies such as visual loss, vascular stenosis and aneurysm formation. Temporal artery biopsy has long been the standard for diagnosing GCA - an invasive technique that lacks sensitivity compared to a clinical diagnosis that relies on a combination of clinical symptoms, elevated serum inflam...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The use of ultrasound for assessing interstitial lung involvement in connective tissue diseases.
Authors: Ferro F, Delle Sedie A Abstract Interstitial lung disease (ILD) is one of the most serious pulmonary complications associated with connective tissue diseases (CTDs), resulting in significant morbidity and mortality. Recently, lung ultrasound examination has appeared as a useful, feasible, non-invasive, radiation-free imaging technique with high sensitivity and specificity for the diagnosis of CTD-associated ILD. In this review, we discuss the literature concerning lung ultrasound findings (B-lines and pleural irregularities) in systemic sclerosis. We also examine the possible utility and potential limitati...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Advances in salivary gland ultrasonography in primary Sj ögren's syndrome.
Advances in salivary gland ultrasonography in primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 Sep-Oct;36 Suppl 114(5):159-164 Authors: Luciano N, Ferro F, Bombardieri S, Baldini C Abstract Salivary gland ultrasonography (US) has recently been re-discovered as a useful tool to assess salivary gland involvement in primary Sjögren's syndrome (SS). In this review, we discuss US of the major salivary glands in the diagnosis of primary SS and analyse the possible added value of inclusion in classification criteria. We review the literature concerning associations between US of the major saliva...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Functional MRI in rheumatic diseases with a focus on fibromyalgia.
Authors: Pamfil C, Choy EHS Abstract Pain is the most common symptom in rheumatic diseases. However, the severity of pain does not correlate with pathology. The lack of an objective test for pain results in clinicians consider pain in patients with fibromyalgia as psychological. Research over the last two decade using functional neuroimaging especially functional MRI scan have demonstrated objectively that patients with fibromyalgia were not malingering. Pain processing is complex and multiple regions of the brain are involved. One consistent finding is decrease activity in regions of the brain involved in pain inh...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Current imaging techniques in osteoporosis.
Authors: Carey JJ, Buehring B Abstract Osteoporosis is a global pandemic affecting children, men and women of all ages and ethnicities. Millions of people suffer fragility fractures each year around the world as a result of this bone disease, which can have devastating consequences for them, including permanent disability and death. Many fractures are preventable by identifying people at high risk for fracture and falls, and diagnosing those who already have osteoporosis, before they fracture. Rheumatologists commonly encounter people with fragile bones, either as an isolated entity, or a co-morbidity to their unde...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Successful use of rituximab in granulomatosis with polyangiitis with aortic inflammation.
We present the case of a 34-year-old male diagnosed with GPA after presenting with sinus and eye inflammation and the ensuing investigation revealed large vessel involvement that remarkably improved after 6 months of treatment with the combination of rituximab infusions, methotrexate and corticosteroids. PMID: 30299239 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antinuclear antibodies in the general population: positive association with inflammatory and vascular biomarkers but not traditional cardiovascular risk factors.
We examined associations of ANA with traditional cardiovascular risk factors, inflammatory mediators, and vascular biomarkers in the Dallas Heart Study - a large, representative multiethnic population-based cohort. Plasma ANA were measured by enzyme linked immunosorbent assay in 3,488 Dallas Heart Study participants aged 30 to 65 years who do not have known rheumatologic disease. Associations of ANA with demographic characteristics, cardiovascular risk factors, and biomarkers were assessed using univariable and multivariable linear regression. RESULTS: Factors independently associated with higher ANA include female sex...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy of tocilizumab monotherapy after response to combined tocilizumab and methotrexate in patients with rheumatoid arthritis: the randomised JUST-ACT study.
CONCLUSIONS: In MTX non-responder patients achieving LDA with TCZ+MTX, switching to TCZ monotherapy is non-inferior to continuing the combination. PMID: 30299241 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Inflammation and cardiovascular disease in familial Mediterranean fever. An analysis of hospital admissions for acute cardiovascular event.
CONCLUSIONS: In FMF patients treated with colchicine, CVD is not associated with FMF-related inflammation. PMID: 30299242 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Why are Beh çet's disease patients always exhausted?
CONCLUSIONS: A better understanding of these complex clinical and biochemical interactions between α-MSH, VIP and IL-6 might lead to the development of novel approaches to manage fatigue and sleep disorders as well as disease activity in BD patients. PMID: 30299243 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Short-term clinical worsening is a clear predictor for worsening at 2 years in established knee and hip osteoarthritis.
CONCLUSIONS: Our findings suggest that re-assessment of symptoms after optimised non-surgical treatment could be meaningful in clinical decision making for TJR. Furthermore, this information could be used to identify subgroups of patients potentially eligible for novel and advanced treatment options. PMID: 30299244 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Epidemiological characteristics of psoriatic arthritis.
Authors: Migkos MP, Somarakis GP, Markatseli TE, Voulgari PV, Drosos AA Abstract Psoriatic arthritis (PsA) is a specific form of inflammatory arthritis associated with skin psoriasis. PsA makes part of a heterogeneous group of arthritides called the spondyloarthropathies. Several studies regarding the prevalence and incidence of PsA have been published during the last decades, showing a considerable variation of the disease occurrence among different populations. The purpose of this review is to discuss recent observations of epidemiological features for PsA patients. Thus, the literature was reviewed until May 201...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Implication of CXCL5 (epithelial neutrophil-activating peptide 78) in the development of insulin resistance in patients with rheumatoid arthritis.
CONCLUSIONS: CXCL5 is not related to IR in RA patients. Therefore, the mechanisms leading to IR in patients with RA may be different from those in the general population. PMID: 30299246 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence of sicca syndrome in the Peruvian population.
CONCLUSIONS: The results of this study show the prevalence of SS in the Peruvian population and serve to strengthen the health strategies of rheumatology, ophthalmology, and oral health to improve the diagnosis, treatment, follow-up of the disease, and the quality of life of patients with SS. PMID: 30299247 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum calprotectin as a marker of clinical and ultrasound-detected synovitis in early psoriatic and rheumatoid arthritis: results from a cross-sectional retrospective study.
CONCLUSIONS: In early PsA, serum calprotectin correlates with US measures of disease activity. Our results provide preliminary evidence for the application of this biomarker in early PsA. PMID: 30299248 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Does the cognitive index of the symptom severity scale (SSS) evaluate cognition? Data from subjective and objective cognitive measures in fibromyalgia.
CONCLUSIONS: No significant relationship was found between FM patients' subjective appraisal of cognitive deficit and objective cognitive scores on all computerised subtests. However, subjective appraisal of cognitive impairment was found to be strongly and significantly related to patients' functional ability. Therefore, we suggest reconsidering the definition of this index score (SSS-Cog) and propose developing novel and more accurately defined tools in order to measure cognitive impairment in FM patients, for both diagnostic and epidemiological purposes. PMID: 30299249 [PubMed - as supplied by publisher] (Source: Cl...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased interleukin-22 levels in lupus nephritis and its associated with disease severity: a study in both patients and lupus-like mice model.
CONCLUSIONS: Our results suggest that IL-22 as a pathogenic cytokine might be a potential target for treatment of lupus nephritis. PMID: 30299250 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical and genetic characteristics of ankylosing spondylitis patients with peripheral arthritis at disease onset.
Authors: Polo Y La Borda J, Szczypiorska M, Bartolomé N, Campos J, Flores-Robles BJ, Sanz J, Fernández-Espartero C, Clavaguera T, Andrus RF, Artieda M, Tejedor D, Martínez A, Mulero J, Isasi CM, Andréu JL, Sánchez A Abstract OBJECTIVES: The aim of this study was to assess the clinical and genetic characteristics associated with the presence of peripheral arthritis (PA) at disease onset in patients with ankylosing spondylitis (AS). METHODS: 456 Spanish AS patients, diagnosed according to the modified New York Criteria, who had at least ten years of follow-up since initial disea...
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association of a polymosrphism of the Fc γ-receptor 2A (FCGR2A) gene with chronic periaortitis.
CONCLUSIONS: In the largest candidate gene approach study performed so far in CP, we demonstrated an association for CP with a gene hallmark of autoimmunity. The association appears restricted to typical cases of CP without increase of IgG4 levels. PMID: 30299252 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 10, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: systemic lupus erythematosus.
Authors: Di Battista M, Marcucci E, Elefante E, Tripoli A, Governato G, Zucchi D, Tani C, Alunno A Abstract Systemic lupus erythematosus (SLE) is a systemic autoimmune condition characterised by a wide spectrum of clinical manifestations, partly related to the disease itself, but also linked to its comorbidities and drugs adverse reactions. Following the previous annual reviews, we focused on new insights in SLE clinical features, pathogenic pathways, biomarkers of specific organ involvement and therapeutic strategies. We finally concentrated on SLE aspects that could significantly influence patients' quality of li...
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Erratum corrige: "Increased expression of interferon- λ in minor salivary glands of patients with primary Sjögren's syndrome and its synergic effect with interferon-α on salivary gland epithelial cells". Y.-J. Ha et al.
Erratum corrige: "Increased expression of interferon-λ in minor salivary glands of patients with primary Sjögren's syndrome and its synergic effect with interferon-α on salivary gland epithelial cells". Y.-J. Ha et al. Clin Exp Rheumatol. 2018 Sep-Oct;36(5):936 Authors: Ha YJ, Choi YS, Kang EH, Chung JH, Cha S, Song YW, Lee YJ PMID: 30272544 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinically relevant redifferentiation of fibroblast-like chondrocytes into functional chondrocytes by the low molecular weight fraction of human serum albumin.
Authors: Hausburg MA, Frederick ED, McNair P, Schwappach J, Banton KL, Roshon M, Lieser MJ, Acuna DL, Banerjee RR, Bar-Or D Abstract OBJECTIVES: Traumatic joint injury induces chondrocyte dysfunction and progressive breakdown of articular cartilage, leading to post-traumatic osteoarthritis (PTOA). In this condition, dysfunctional fibroblast-like chondrocytes (FLCs) no longer express proteins required for cartilage maintenance, such as SOX9 and collagen-type II (COL2). Interleukin-6 (IL-6) has been demonstrated to downregulate expression of these two critical proteins in chondrocytes, and increased IL-6 levels have ...
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The challenge of pet therapy in systemic sclerosis: evidence for an impact on pain, anxiety, neuroticism and social interaction.
Authors: Fiori G, Marzi T, Bartoli F, Bruni C, Ciceroni C, Palomba M, Zolferino M, Corsi E, Galimberti M, Moggi Pignone A, Viggiano MP, Guiducci S, Calamai M, Matucci-Cerinic M Abstract OBJECTIVES: The aim of our study was to evaluate the effect of animal-assisted intervention (AAI), a complementary support to traditional therapies focused on the interaction between animals and human beings, in improving psychological trait, anxiety and pain in a cohort of systemic sclerosis (SSc) patients. METHODS: 42 SSc patients, undergoing iloprost intravenous infusion, were divided in three groups: 1) 14 patients submitted...
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Gender differences in early systemic sclerosis patients: a report from the EULAR scleroderma trials and research group (EUSTAR) database.
Authors: Carreira PE, Carmona L, Joven BE, Loza E, Andreu JL, Riemekasten G, Vettori S, Balbir-Gurman A, Airò P, Walker UA, Damjanov N, Matucci-Cerinic M, Ananieva LP, Rednic S, Czirják L, Distler O, Farge D, Hesselstrand R, Corrado A, Caramaschi P, Tikly M, Allanore Y, and the EUSTAR co-authors Abstract OBJECTIVES: To describe differences in clinical presentation between men and women in a large group of patients with early (
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Simultaneous inhibition of c-Abl and Src kinases abrogates the exaggerated expression of profibrotic genes in cultured systemic sclerosis dermal fibroblasts.
CONCLUSIONS: Simultaneous inhibition of c-Abl and Src kinases with Bosutinib abrogates the exaggerated expression of genes encoding fibrillar collagens, fibronectin, and TGF-β-responsive genes and reduces type I collagen, fibronectin and α-SMA production by SSc dermal fibroblasts in vitro. Bosutinib also abrogates TGF- β-induced transition of normal fibroblasts to activated myofibroblasts. These results indicate that inhibition of c-Abl and Src kinases activity may be an effective disease modifying antifibrotic therapeutic intervention for SSc. PMID: 30277861 [PubMed - in process] (Source: Clinical and ...
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial.
CONCLUSIONS: In this small trial we did not observe any effect of blocking IL-1 on clinical skin disease or biomarkers of IL-1 activity. PMID: 30277862 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Usefulness of six-minute walk test in systemic sclerosis.
Authors: Rizzi M, Radovanovic D, Santus P, Airoldi A, Frassanito F, Vanni S, Cristiano A, Sarzi-Puttini P, Atzeni F Abstract The 6-minute walk test (6MWT) is a standardised, feasible and reliable measure of sub-maximal exercise capacity that has never been fully validated in systemic sclerosis (SSc). A variety of data suggest that many non-pulmonary aspects of SSc contribute to the test results, thus blunting the ability of the 6MWT to measure changes in lung function. Sources of variability are a training effect, technician experience, subject encouragement, medication, other activities on day of testing, decondit...
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Combination therapy with rituximab and mycophenolate mofetil in systemic sclerosis. A single-centre case series study.
CONCLUSIONS: Despite preliminary results and limited to a small number of patients, our data suggest that therapy with RTX and MMF is well tolerated, safe, and potentially effective for cutaneous and pulmonary involvement in SSc. PMID: 30277864 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research