Association between increased arterial stiffness measured by brachial-ankle pulse wave velocity and cardiovascular events in Takayasu's arteritis patients.
This study aims to investigate the association between arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) and cardiovascular events (CVEs) in patients with Takayasu's arteritis (TAK). METHODS: A total of 240 TAK patients, who underwent baPWV measurement, were included in the study. The primary outcome was CVEs, which was defined as presently or previously diagnosed with myocardial infarction, unstable angina, congestive heart failure, aortic aneurysm/dissection, cerebral infarction/transient ischaemic attack (TIA), or cerebral haemorrhage. RESULTS: A total of 74 (30.8%) patients with CVEs wer...
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of obesity on inflammation and damage in spondyloarthritis: a systematic literature review on body mass index and imaging.
CONCLUSIONS: BMI is linked to both axial and peripheral new bone formation and entheseal inflammation by imaging, as supported by the limited number of studies in the literature. Its effect on the sacroiliac joint and spinal inflammation is not clear as MRI studies are lacking. PMID: 31074718 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sirolimus selectively increases circulating Treg cell numbers and restores the Th17/Treg balance in rheumatoid arthritis patients with low disease activity or in DAS28 remission who previously received conventional disease-modifying anti-rheumatic drugs.
CONCLUSIONS: Sirolimus can favourably expand Treg cells in RA patients with DAS28 ≤3.2, consequently restoring a healthy balance of Th17/Treg cells, which might improve the likelihood of long-term and sustained clinical remission and reduce the probability of disease flare-ups in RA. PMID: 31074719 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.
CONCLUSIONS: Taken together, our findings suggest that high levels of LDL/oxLDL during inflammation, dampen the initiation and chronicity of joint inflammation and cartilage destruction in AIA by regulating macrophage FcγR expression. PMID: 31074720 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Retrospective evaluation of patient profiling and effectiveness of apremilast in an Italian multicentric cohort of psoriatic arthritis patients.
CONCLUSIONS: In our real-life analysis apremilast was mainly used in oligoarticular PsA carrying comorbidities leading to contraindications to biologics. Effectiveness and safety profiles were consistent with clinical trials. PMID: 31074721 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Elevated serum levels of alarmin S100A8/A9 in patients with hand osteoarthritis.
Authors: Addimanda O, Pulsatelli L, Vogl T, Roth J, Mancarella L, Assirelli E, Ramonda R, Fioravanti A, Meliconi R PMID: 31074722 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

HIV-associated vasculitis. Part II: histologic and angiographic diagnostic reconfirmation after an uncontrolled HIV infection and fatal outcome.
Authors: Laurent C, Marçal AL, Prieto-González S, Balagué O, Morales X, Darnell A, Ripoll E, Cid MC, Hernández-Rodríguez J PMID: 31074723 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comments on the giant cell arteritis probability score.
Authors: Ing E, Sambhi G, Torun N, Pagnoux C PMID: 31074724 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Progranulin-autoantibodies in sera of rheumatoid arthritis patients negative for rheumatoid factor and anti-citrullinated peptide antibodies.
CONCLUSIONS: These data suggest that the determination of PGRN-abs in seronegative RA patients may reduce their seronegative status. Further studies are required to evaluate PGRN-abs as a potential diagnostic marker in RA. PMID: 31074725 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Presence of intraepithelial B-lymphocytes is associated with the formation of lymphoepithelial lesions in salivary glands of primary Sj ögren's syndrome patients.
CONCLUSIONS: We conclude there is an association between presence of intraepithelial B-lymphocytes and the formation of LELs in salivary glands of pSS patients. PMID: 31074726 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The influence of immunosuppressants on the non-melanoma skin cancer among patients with systemic lupus erythematosus and primary Sj ögren's syndrome: a nationwide retrospective case-control study in Taiwan.
CONCLUSIONS: The patients with SLE or pSS had significantly increased associations with NMSC, especially those receiving higher cumulative doses of corticosteroids and hydroxychloroquine. PMID: 31074727 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of osteopontin as a candidate biomarker of renal involvement in systemic lupus erythematosus.
Authors: Spinelli FR, Garufi C, Truglia S, Pacucci VA, Morello F, Miranda F, Perricone C, Ceccarelli F, Valesini G, Conti F Abstract OBJECTIVES: Kidney biopsy is the gold standard for the diagnosis of lupus nephritis (LN). Conventional biomarkers of disease activity or renal function, such as complement levels, anti-dsDNA, serum creatinine, urinary sediment and proteinuria, do not have a sensitive diagnostic and prognostic value, therefore new biomarkers are needed to help predict or monitor LN. Osteopontin (OPN) is a pro-inflammatory molecule detectable in serum and renal tissue. The aim of this study was to evalu...
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and adverse effects of methotrexate compared with azathioprine in the antisynthetase syndrome.
CONCLUSIONS: AZA and MTX showed similar efficacy and adverse events in patients with ASyS. Pneumonitis is a rare but important event in patients receiving MTX. PMID: 31074729 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Health-related quality of life, illness perception, coping strategies and the distribution of dependency in autoinflammatory diseases.
Authors: Cipolletta S, Giudici L, Punzi L, Galozzi P, Sfriso P PMID: 31025921 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Interleukin-6 expression in inflamed and non-inflamed temporal arteries from patients with giant cell arteritis.
CONCLUSIONS: Interleukin-6 expression does not increase the sensitivity of temporal artery biopsy in patients with giant cell arteritis who have morphologically uninflamed arteries. PMID: 31025922 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Adiponectin promotes fibroblast-like synoviocytes producing IL-6 to enhance T follicular helper cells response in rheumatoid arthritis.
CONCLUSIONS: Our study demonstrated that AD-stimulated RA FLSs promote Tfh cell generation, which is mainly mediated by the secretion of soluble factor IL-6. This finding reveals a novel mechanism for AD in RA pathogenesis. PMID: 31025923 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Primary efficacy of netakimab, a novel interleukin-17 inhibitor, in the treatment of active ankylosing spondylitis in adults.
CONCLUSIONS: The data obtained demonstrate the efficacy and favourable safety profile of NTK in active AS. Clinical development of NTK will be continued in a phase 3 trial aimed to evaluate the efficacy of 1-year treatment with NTK 120 mg in patients with AS. PMID: 31025924 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Different drug survival of first line tumour necrosis factor inhibitors in radiographic and non-radiographic axial spondyloarthritis: a multicentre retrospective survey.
CONCLUSIONS: Effectiveness of TNFi, seems to be lower in nr-axSpA patients than in those with r-axSpA. In addition obesity and functional disability negatively impact the persistence on first line TNFi in axSpA patients in real life setting. PMID: 31025925 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

FGF23-Klotho axis in patients with rheumatoid arthritis.
Authors: Alvarez-Cienfuegos A, Cantero-Nieto L, Garcia-Gomez JA, Robledo G, González-Gay MA, Ortego-Centeno N Abstract OBJECTIVES: We aimed to compare serum Klotho and fibroblast growth factor-23 (FGF-23) levels between rheumatoid arthritis (RA) patients and healthy controls. Possible association between FGF-23 and soluble Klotho with different characteristic of the disease as well as their potential role as surrogate markers of cardiovascular disease (CVD) were studied. METHODS: Sixty-three patients with RA recruited at Vega-Baja Hospital, Orihuela (Spain) from November 2016 to May 2018 and sixty-five a...
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Low-dose computed tomography as diagnostic tool in calcium pyrophosphate deposition disease arthropathy: focus on ligamentous calcifications of the wrist.
Authors: Ziegeler K, Diekhoff T, Hermann S, Hamm B, Hermann KGA Abstract OBJECTIVES: To identify specific morphologic features of calcium pyrophosphate deposition disease (pseudogout, CPPD) manifestations of the wrist as detected using low-dose CT-scans. METHODS: In this retrospective study 46 patients with arthritis of the wrist were included. All patients underwent a low dose CT scan of both wrists on a 320-row detector in volume scan mode. Individual radiation exposure was recorded for all patients. Two blinded raters independently evaluated osteoarthritis, cysts, erosions, calcifications (cartilage and liga...
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum IgG4 elevation in SAPHO syndrome: does it unmask a disease activity marker?
Authors: Li C, Xiang Y, Wu X, Cao Y, Zhao Y, Sun X, Wu N, Zhang W Abstract OBJECTIVES: SAPHO syndrome is a rare inflammatory disorder with multiple phenotypes, including synovitis, acne, pustulosis, hyperostosis, and osteitis. IgG4 is a subclass of immunoglobulin G, and the elevation of IgG4 has been found in different autoimmune diseases. In the present study, we explored the clinical significance of serum IgG4 levels in patients with SAPHO syndrome. METHODS: Fifty-two patients who met the classification criteria of SAPHO syndrome were included in this study. Clinical data and disease activity markers were col...
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Results from an American pilot survey among Scleroderma Clinical Trials Consortium members on capillaroscopy use and how to best implement nailfold capillaroscopy training.
Authors: Snow MH, Saketkoo LA, Frech TM, Stever JR, Lebedoff N, Herrick AL, Cutolo M, Smith V PMID: 31025929 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Early and late responses in patients with rheumatoid arthritis who were conventional synthetic disease-modifying anti-rheumatic drug inadequate responders and were treated with tocilizumab or switched to rituximab: an open-label phase 3 trial (MIRAI).
CONCLUSIONS: Early response to tocilizumab was observed in 42.8% of patients. Half of early partial responders benefitted from continuing tocilizumab. Switching non-responders to rituximab seems feasible. No new safety signals were observed in patients treated with tocilizumab or switched to rituximab. PMID: 31025930 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Present and novel biologic drugs in primary Sj ögren's syndrome.
Present and novel biologic drugs in primary Sjögren's syndrome. Clin Exp Rheumatol. 2019 Apr 26; Authors: Fasano S, Isenberg DA Abstract Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by xerostomia and xerophthalmia. In at least one-third of patients, the disease may be complicated by extraglandular involvement. Due to the lack of evidence-based recommendations, current therapeutic options for pSS are mainly empirical, often reflecting their use in other autoimmune diseases. Nevertheless, recent advances in the understanding of pathogenic pathways in pSS encou...
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A new avenue in the pathogenesis of systemic sclerosis: the molecular interface between the endothelial and the nervous systems.
Authors: Romano E, Rosa I, Fioretto BS, Guiducci S, Manetti M, Matucci-Cerinic M Abstract Systemic sclerosis (SSc) is a connective tissue disorder characterised by immune dysregulation, endothelial cell dysfunction followed by defective vascular repair and neovascularization and progressive tissue fibrosis of the skin and internal organs, whose pathophysiology remains to be fully elucidated. Perturbed neuroendothelial control mechanisms comprising either endothelial cell or peripheral nerve fiber impairment are supposed to play an important role in the onset of Raynaud's phenomenon and development of microvascular ...
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Patients' experiences with Beh çet's syndrome: structured interviews among patients with different types of organ involvement.
CONCLUSIONS: Patients with BS identified several domains, including physical functioning, psychological state, and social identity that are significantly modulated by the symptoms of BS. Those are inter-related with physical symptoms, reflecting the multi-system character of BS, and impair patients' function impacting on psychological and social identities. This work advances an understanding of BS, and will be useful in developing patient-oriented outcome measures for use in studying BS. PMID: 31025933 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cigarette smoking and clinical response to certolizumab pegol treatment in Hungarian, Czech, and Slovak patients with rheumatoid arthritis: 104-week data from the CIMDORA prospective, non-interventional study.
CONCLUSIONS: After 104 weeks of CZP treatment, patients demonstrated similar DAS28(ESR) improvements, irrespective of smoking history. PMID: 30963993 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 10, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Genetic markers associated with clinical and radiographic response in adalimumab plus methotrexate-treated rheumatoid arthritis patients in OPTIMA.
CONCLUSIONS: This pharmacogenetic analysis identified genetic components that contribute to clinical responses to anti-rheumatic therapy. PMID: 30963994 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 10, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Faecal microbiota transplantation for Clostridium difficile infection resulting in a decrease in psoriatic arthritis disease activity.
Authors: Selvanderan SP, Goldblatt F, Nguyen NQ, Costello SP PMID: 30943129 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A complex pattern of autonomic dysfunction in familial Mediterranean fever. Results from a controlled cross-sectional study.
Authors: Moog P, Valda K, Eren OE, Rauschel V, Kossegg SJ, Bachmann Q, Schmaderer C, Straube A, Schulze-Koops H, Witt M Abstract OBJECTIVES: Autonomic dysfunction (AD) has been described in various chronic inflammatory diseases. Studies of AD in patients with familial Mediterranean fever (FMF) are inconclusive. We aimed to assess AD in a cohort of FMF patients. METHODS: Signs and symptoms of AD were investigated in patients with FMF and compared to age and gender matched healthy controls. Symptoms of AD were assessed by COMPASS-31, a validated questionnaire to evaluate orthostatic, vasomotor, secretomotor, gast...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Vascular stiffness: influencing factors on carotid-femoral pulse wave velocity in systemic lupus erythematosus.
Authors: Stortz M, Triantafyllias K, Schwarting A, Weinmann-Menke J Abstract OBJECTIVES: Patients with systemic lupus erythematosus (SLE) are under increased risk for cardiovascular events (CVE) and mortality. Aortic stiffness, as measured by carotid-femoral pulse wave velocity (cfPWV), has been shown to predict CVE and mortality in the general population. The aim of the present study was to examine the factors associated with cfPWV in patients with SLE and to determine differences of SLE patients in comparison to healthy controls. METHODS: 125 patients with SLE and 104 controls were included. Demographic, medi...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Study on the association of serum pentraxin-3 and lysosomal-associated membrane protein-2 levels with disease activity in Chinese Takayasu's arteritis patients.
Authors: Chen Z, Hu C, Sun F, Li J, Yang Y, Tian X, Zeng X Abstract OBJECTIVES: To evaluate the association between disease activity and serum levels of pentraxin-3 (PTX-3) and lysosomal-associated membrane protein-2 (LAMP-2) as well as the acute reactants in Chinese Takayasu's arteritis (TAK) patients. METHODS: The serum PTX-3 and LAMP-2 levels were tested in 98 TAK patients and 40 age- and gender-matched healthy controls. The disease activity of these TAK patients was assessed according to the National Institute of Health (NIH) and Abatacept in giant cell arteritis and Takayasu's arteritis (AGATA) criteria, r...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and safety of certolizumab pegol and golimumab in the treatment of non-infectious uveitis.
CONCLUSIONS: GOL and CZP represent effective and safe treatment choices for patients with uveitis also when unsuccessfully treated with other anti-TNF-α drugs, permitting a significant reduction in the frequency of ocular flares and preserving visual function with a good long-term retention rate. PMID: 30943133 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Systemic lupus erythematosus is a risk factor for atrial fibrillation: a nation-wide, population-based study.
Authors: Lim SY, Bae EH, Han KD, Jung JH, Choi HS, Kim CS, Ma SK, Kim SW Abstract OBJECTIVES: Cardiac involvement is present in more than half of the patients with systemic lupus erythematosus (SLE). However, large-scale studies on the prevalence of atrial fibrillation (AF) in this disease do not exist. We aimed to investigate the incidence and clinical significance of AF in SLE. METHODS: Patients with SLE (n=21,143; mean age, 41.8±13.13 years; female, 90.38%) without previous AF were selected from the Korean National Health Insurance Service National Sample Cohort database between 2008 and 2014. Age-and...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Are antibodies against La (SSB) no longer useful for the diagnosis of Sj ögren's syndrome?
Are antibodies against La (SSB) no longer useful for the diagnosis of Sjögren's syndrome? Clin Exp Rheumatol. 2019 Apr 02; Authors: Spoerl D, Roux-Lombard P PMID: 30943135 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Role of cannabinoid receptor 2 in mediating interleukin-1 β-induced inflammation in rheumatoid arthritis synovial fibroblasts.
CONCLUSIONS: Overall, our results indicate for the first time that CB2 mediates IL-1β-induced signalling pathways in RASFs and may serve as a potential target to manage pain and inflammation in RA. PMID: 30943136 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cardiometabolic risk and subclinical vascular damage assessment in idiopathic inflammatory myopathies: a challenge for the clinician.
Authors: Barsotti S, Saponaro C, Gaggini M, Talarico R, Bianchini E, Di Lascio N, Ferrari C, Buzzigoli E, Mosca M, Gastaldelli A, Neri R, Morales MA Abstract OBJECTIVES: A high prevalence of cardiovascular disease (CVD), not fully explained by the prevalence of traditional risk factors only, is reported in patients with idiopathic inflammatory myopathies (IIMs). Thus, we investigated if novel markers of CVD risk, like carotid diameter and advanced glycated end products, can better predict increased CVD risk in IIM patients. METHODS: We studied 43 consecutive patients diagnosed with IIM. All the patients underwe...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pain and bone damage in rheumatoid arthritis: role of leukotriene B4.
Authors: Zheng LX, Li KX, Hong FF, Yang SL Abstract Rheumatoid arthritis is a chronic autoimmune disease characterised by unbearable joint pain as well as bone and cartilage destruction. Although RA development is greatly controlled, the pain and bone damage failed to be relieved and managed. Leukotriene B4 (LTB4) has been proved to play an essential role in the induction of pain and bone damage. The nerve injury of RA can promote the production of LTB4, which act on their receptors, leading to the increased release of pro-inflammatory cytokines and ROS to reduce neuron viability and pain threshold. Moreover, LTB4-...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antidrug antibody detection for adalimumab depends on the type of assay used: an experimental approach to help clinicians interpret diagnostic data.
CONCLUSIONS: The majority of AS patients had detectable ADA against adalimumab in the ARIA. The ARIA detects more ADA compared to the less drug tolerant ABT and bridging ELISA. The clinical relevance depends on the impact on the bio-availability of the drug. A drug level measurement therefore helps to interpret ADA data regardless of type of assay used. PMID: 30943139 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Aortic angiosarcoma masquerading as inflammatory aortitis.
Authors: Boustani M, Dion J, Benali K, Sigal-Cinqualbre A, Crahes M, Alsac JM, Revel MP, Mouthon L, Le Jeunne C, Régent A PMID: 30943140 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

High cardiovascular risk in mixed connective tissue disease: evaluation of macrovascular involvement and its predictors by aortic pulse wave velocity.
Authors: Triantafyllias K, de Blasi M, Lütgendorf F, Cavagna L, Stortz M, Weinmann-Menke J, Konstantinides S, Galle PR, Schwarting A Abstract OBJECTIVES: Macrovascular involvement and cardiovascular (CV) risk has not been sufficiently studied in mixed connective tissue disease (MCTD). In particular, the gold standard assessment method of aortic stiffness carotid-femoral pulse wave velocity (cfPWV) has never been evaluated in patients with this disease. The aims of the present study were therefore to examine cfPWV in MCTD and to evaluate its associations with MCTD-associated markers and traditional CV risk fact...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Risk of congenital anomalies in infants born to women with autoimmune disease using biologics before or during pregnancy: a population-based cohort study.
CONCLUSIONS: These population-based data suggest that the use of biologics before and during pregnancy is not associated with an increased risk of congenital anomalies. PMID: 30943142 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases.
Authors: Lamot L, Niemietz I, Brown KL Abstract Type I interferons (IFN) are a class of inducible and protective cytokines best known for immune defence against viruses and intracellular bacteria. Inappropriate stimulation or defective negative regulation of type I IFN expression however can lead to persistent type I IFN activity with detrimental effects. This is particularly relevant for a class of monogenic autoinflammatory diseases ("type I interferonopathies"), along with many other complex rheumatic diseases such as systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), r...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

When chest pain is not "just" Tietze's syndrome: a case of non-Hodgkin's lymphoma.
When chest pain is not "just" Tietze's syndrome: a case of non-Hodgkin's lymphoma. Clin Exp Rheumatol. 2019 Apr 02; Authors: Cipolletta E, Di Matteo A, Incorvaia A, Di Carlo M, Filippucci E, Grassi W PMID: 30943144 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Observational study on the QUality of life of Italian Axial SpondyloARthritis patients (QUASAR): baseline data.
CONCLUSIONS: QUASAR is the first Italian prospective study that comprehensively evaluated a large axSpA patient sample in a real-world setting. This interim analysis at baseline confirmed that i) patients with AS and nr-axSpA have similar QoL and disease burden, ii) nearly all axSpA patients receive treatment, and iii) bDMARDs and NSAIDs, overall, yield better disease activity and QoL. PMID: 30943145 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Adherence in rheumatoid arthritis patients assessed with a validated Italian version of the 5-item Compliance Questionnaire for Rheumatology.
Authors: Ometto F, Raffeiner B, Azzolina D, Botsios C, Astorri D, Friso L, Favero M, Done DJ, Gregori D, Doria A Abstract OBJECTIVES: The 5-item Compliance Questionnaire for Rheumatology (CQR5) proved reliability and validity in respect of identification of patients likely to be high adherers (HAs) to anti-rheumatic treatment, or low adherers (LAs), i.e. taking
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

IL-6 and TGF- β gene polymorphisms, their serum levels, as well as HLA profile, in patients with systemic lupus erythematosus.
IL-6 and TGF-β gene polymorphisms, their serum levels, as well as HLA profile, in patients with systemic lupus erythematosus. Clin Exp Rheumatol. 2019 Mar 18; Authors: Paradowska-Gorycka A, Roszak M, Stypinska B, Lutkowska A, Walczyk M, Olesinska M, Wajda A, Piotrowski P, Puszczewicz M, Majewski D, Jagodzinski PP Abstract OBJECTIVES: The aim of the study was to explore whether TGF-β and IL-6 gene polymorphisms may be associated with SLE and assess the frequency of HLA-DRB1 alleles in Polish systemic lupus erythematosus (SLE) patients. METHODS: 216 SLE patients and 552 healthy individuals ...
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pilot study: non-steroidal anti-inflammatory drugs attenuate active inflammatory sacroiliac joint lesions in patients with early axial spondyloarthritis.
Authors: Min HK, Cho H, Park SH PMID: 30943148 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 5, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: psoriatic arthritis.
Authors: Calabresi E, Monti S, Governato G, Carli L Abstract Spondyloarthritis (SpA) is an inflammatory condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features that genetically tend to be associated with the major histocompatibility complex class 1 antigen, HLA-B27, and in which both peripheral and axial joints might be affected. In addition to arthritis, the typical musculoskeletal manifestations are enthesitis and dactylitis. Extraarticular manifestations such as acute anterior uveitis (AAU), psoriasis (PsO) and inflammatory bowel disease (IBD) are al...
Source: Clinical and Experimental Rheumatology - March 24, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Erratum corrige: "Peripheral CD4+CD28null T-cells as predictors of damage in systemic lupus erythematosus patients". M.F. Ugarte-Gil et al.
Erratum corrige: "Peripheral CD4+CD28null T-cells as predictors of damage in systemic lupus erythematosus patients". M.F. Ugarte-Gil et al. Clin Exp Rheumatol. 2019 Mar-Apr;37(2):345 Authors: Ugarte-Gil MF, Sánchez-Zúñiga C, Gamboa-Cardenas RV, Aliaga-Zamudio M, Zevallos F, Mosqueira-Riveros A, Medina-Chinchón M, Tineo-Pozo G, Elera-Fitzcarrald C, Pimentel-Quiroz V, Sarmiento-Velasquez O, Reátegui-Sokolova C, Cucho-Venegas JM, Alfaro-Lozano J, Rodriguez-Bellido Z, Pastor-Asurza CA, Alarcón GS, Perich-Campos R PMID: 30900549 [PubMed - in process] (Source: ...
Source: Clinical and Experimental Rheumatology - March 24, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research