Overweight and obesity affect clinical assessment of synovitis in rheumatoid arthritis: comparison of ultrasonography and clinical exam.
CONCLUSIONS: In high BMI RA patients both SJC and DAS28 seem to be undervalued by clinical assessment when compared to US. PMID: 29998844 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Why male patients with Beh çet's disease prone to thrombosis? A rotational thromboelastographic analysis.
Why male patients with Behçet's disease prone to thrombosis? A rotational thromboelastographic analysis. Clin Exp Rheumatol. 2018 Jun 08; Authors: Kara Kivanc B, Gönüllü E, Akay OM, Ertürk A, Bal C, Cansu DÜ, Korkmaz C Abstract OBJECTIVES: To investigate whether there is a difference between male and female patients with Behçet's disease (BD) in terms of hypercoagulability by using modified rotational thromboelastograhic (ROTEM) analysis. METHODS: 126 BD patients (71 male, 55 female; mean age: 41±9 yrs) who met ISSG criteria for BD were included into th...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Relationship between cerebrovascular and valvular manifestations in a Serbian cohort of patients with antiphospholipid syndrome.
CONCLUSIONS: In this cross-section analysis of a large cohort of Serbian APS patients, there was a strong relationship between valvular and cerebrovascular manifestations, suggesting a more cautious approach regarding neurological symptoms, especially in PAPS patients with valvular vegetations present. PMID: 29846156 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Role of serum autoantibodies in blood brain barrier damages in neuropsychiatric systemic lupus erythematosus.
CONCLUSIONS: The data demonstrate that serum anti-Sm antibodies play a most important role in the disruption of BBB in NPSLE. PMID: 29846157 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Peripheral nervous system involvement in systemic lupus erythematosus: a review of the evidence.
Authors: Bortoluzzi A, Silvagni E, Furini F, Piga M, Govoni M Abstract In the past years the peripheral nervous system (PNS) involvement in systemic lupus erythematosus (SLE) has received little attention despite its potential significant impact. The true prevalence of PNS in SLE reported in studies is variable and strongly influenced by American College of Rheumatology (ACR) case definition that includes seven PNS manifestations (acute inflammatory demyelinating polyradiculoneuropathy, autonomic disorder, mononeuropathy, myasthenia gravis, cranial neuropathy, plexopathy and polyneuropathy). Other peripheral manife...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Entheseal involvement in asymptomatic human immunodeficiency virus infected patients: preliminary results of a clinical and ultrasonographic study.
Authors: Ciancio G, Sighinolfi L, Furini F, Segala D, Farina I, Galuppi E, De Stefani E, Simone L, Boccia S, Grilli A, Pazzi P, Libanore M, Contini C, Govoni M Abstract OBJECTIVES: As a strong association between human immunodeficiency virus (HIV) infection and spondyloarthritis (SpA) has been hypothesised, our main objective was to explore by power Doppler ultrasonography (PDUS) the presence of subclinical enthesitis in asymptomatic HIV patients. The presence of subclinical synovitis was also evaluated. METHODS: Consecutive asymptomatic HIV patients were studied and compared with asymptomatic HCV patients and ...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rheumatic diseases and pregnancy: a national survey about practice patterns among rheumatologists and obstetricians.
Authors: Fayad F, Ziade N, Karam GA, Ghaname W, Khamashta M Abstract OBJECTIVES: Management of rheumatic diseases (RD) is often problematic in pregnant patients, hence the need for guideline implementation. This survey-based study aimed to assess beliefs among obstetricians and rheumatologists about managing RD in pregnant Lebanese patients. METHODS: Questionnaires were completed by a representative sample of rheumatologists and obstetricians practicing throughout Lebanon. Collected data included physicians' information, opinion on pregnancy in RD patients, compatible drugs with fertility, pregnancy and breastf...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence and spectrum of symptomatic pulmonary involvement in primary Sj ögren's syndrome.
CONCLUSIONS: Approximately one fifth of a large cohort of pSS patients presented chronic respiratory symptoms. Small airway disease was the most commonly recognized pulmonary disorder among symptomatic pSS patients, followed by xerotrachea and interstitial lung disease. PMID: 29846161 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Appropriate cardiovascular disease risk assessment in systemic lupus erythematosus may be lacking in rheumatology practice.
CONCLUSIONS: CV risk assessment and preventative measures were inconsistent when rheumatologists monitored SLE patients, indicating a care gap. Improved communication between rheumatologists and family physicians with respect to elevated CVD risk in SLE is needed. PMID: 29846162 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Expression profile of long noncoding RNAs in children with systemic lupus erythematosus: a microarray analysis.
CONCLUSIONS: We firstly characterised the expression profiles of lncRNA and mRNA in children with SLE and propose herein their possible roles in the pathogenesis of SLE. These results provide novel insights into the mechanisms of SLE pathogenesis and may serve as diagnostic biomarkers for SLE therapy. PMID: 29846163 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sj ögren's syndrome: disease activity indexes! Do they make us better clinicians or technicians?
Sjögren's syndrome: disease activity indexes! Do they make us better clinicians or technicians? Clin Exp Rheumatol. 2018 May 25; Authors: Moutsopoulos HM, Skopouli FN PMID: 29846164 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Risk factors of relapse following glucocorticoid tapering in IgG4-related disease.
CONCLUSIONS: Higher levels of serum IgG4 at baseline were associated with relapse in IgG4-RD. Re-elevation of serum IgG4 levels during GC treatment reflected disease relapse. PMID: 29846165 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Vitamin D deficiency in connective tissue disease-associated interstitial  lung disease.
Vitamin D deficiency in connective tissue disease-associated interstitial lung disease. Clin Exp Rheumatol. 2018 May 24; Authors: Deng M, Tang L, Huang D, Wang Z, Chen J Abstract OBJECTIVES: To determine and compare the prevalence of vitamin D deficiency in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). METHODS: The level of vitamin D was determined by the serum levels of 1,25(OH)2D3. We evaluated 144 patients in our study, including 53 subjects in the CTD-ILD group and 91 subjects in the CTD group without ILD. CTD was diagnosed following the Ameri...
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Systemic lupus erythematosus in PubMed: a review of the articles published in 2016.
Authors: Jiménez Alonso J, Vargas Hitos JA, Zamora Pasadas M, Navarrete Navarrete N, Jáimez L, Sabio JM PMID: 29846167 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

IgG4-related disease: features and treatment response in a multi-ethnic cohort in Singapore.
CONCLUSIONS: Pancreatitis, lymphoadenopathy and cholangitis were the commonest manifestations in Asians with IgG4-RD. All patients responded to glucocorticoid therapy by 3 months, two-thirds required maintenance therapy with glucocorticoids, and one-quarter developed relapse of disease. PMID: 29846168 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: novelties in the treatment of rheumatoid arthritis.
Authors: Bortoluzzi A, Furini F, Generali E, Silvagni E, Luciano N, Scirè CA Abstract The current approach to treatment of rheumatoid arthritis (RA) includes early and aggressive intervention aiming to reach early and persistent low disease activity and remission. New drugs have improved the therapeutic armamentarium of rheumatologists, providing new options for patients. Beyond these innovations, new evidence has improved the safety of therapies and provided tools for the optimisation of long-term management of RA. This paper reviews the most relevant studies published over the last year in the field of tre...
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Subclinical aortitis after starting nivolumab in a patient with metastatic melanoma. A case of drug-associated aortitis?
Authors: Loricera J, Hernández JL, García-Castaño A, Martínez-Rodríguez I, González-Gay MÁ, Blanco R PMID: 29799390 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Manifestation of granulomatosis with polyangiitis in head and neck.
CONCLUSIONS: The data of the largest monocentric study presented here demonstrate a frequent ENT-involvement in GPA patients. Rhinological and ontological manifestations are most common. PMID: 29799391 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Highlights of the 2nd EUVAS Vasculitis Course.
Authors: Emmi G, Salvarani C, Prisco D, Jayne DRW, Vaglio A PMID: 29799392 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Distribution patterns of 18F-fluorodeoxyglucose in large vessels of Takayasu's and giant cell arteritis using positron emission tomography.
Authors: Soriano A, Pazzola G, Boiardi L, Casali M, Muratore F, Pipitone N, Catanoso M, Aldigeri R, Cimino L, Versari A, Salvarani C Abstract OBJECTIVES: To compare patterns of vascular involvement using 18F-fluorodeoxyglucose-positron emission tomography computed tomography (FDG PET/CT) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK). METHODS: A total of 130 consecutive 18F-FDG PET/CT scans performed during the disease course for evaluating disease activity in 15 GCA and 13 TAK patients were retrospectively examined by two nuclear physicians blinded to clinical data. Standardised upt...
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rate of infections in severe necrotising vasculitis patients treated with cyclophosphamide induction therapy: a meta-analysis.
CONCLUSIONS: The rate of severe infections and infection related mortality in patients with severe necrotising vasculitis treated with CYC + GC induction therapy is high. PMID: 29799394 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: systemic vasculitis.
Authors: Elefante E, Bond M, Monti S, Lepri G, Cavallaro E, Felicetti M, Calabresi E, Posarelli C, Talarico R, Quartuccio L, Baldini C Abstract Systemic vasculitis are heterogeneous, complex and disabling disorders. Following the previous annual reviews of this series, this paper gives a brief overview on current knowledge about recent literature on small- and large-vessel systemic vasculitis, with a specific focus on pathogenetic and clinical aspects, novel possible disease-related biomarkers and current and future therapies that are in the pipeline. PMID: 29799395 [PubMed - in process] (Source: Clinical and E...
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Circulating CD4+CD8+ double-positive T-cells display features of innate and adaptive immune function in granulomatosis with polyangiitis.
CONCLUSIONS: Employing a combined phenotypic and transcriptomic approach we disclosed a Th1/Th17 phenotype as well as innate and adaptive functions of CD4+CD8+ double-positive T-cells in GPA. PMID: 29799396 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Parasympathetic activity increases with digital microvascular damage and vascular endothelial growth factor in systemic sclerosis.
Authors: Gigante A, Margiotta D, Navarini L, Liberatori M, Barbano B, Tubani L, Afeltra A, Rosato E Abstract OBJECTIVES: The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF). METHODS: Twenty-seven SSc patients ...
Source: Clinical and Experimental Rheumatology - May 23, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Venous thrombosis and relapses in patients with Beh çet's disease. Descriptive analysis from Spanish network of Behçet's disease (REGEB cohort).
CONCLUSIONS: We identified factors related with venous involvement in patients included in the REGEB cohort. PMID: 29745871 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Effects of autonomic dysfunction on exercise tolerance in systemic sclerosis patients without clinical and instrumental evidence of cardiac and pulmonary involvement.
CONCLUSIONS: In SSc patients without cardiopulmonary involvement AD is associated with better exercise tolerance and cardiac function during physical effort. Further studies are needed to confirm these results. PMID: 29745872 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Do antimalarials protect against damage accrual in primary Sj ögren's syndrome? Results from a Latin-American retrospective cohort.
Do antimalarials protect against damage accrual in primary Sjögren's syndrome? Results from a Latin-American retrospective cohort. Clin Exp Rheumatol. 2018 Apr 19; Authors: Hernández-Molina G, Valim V, Secco A, Atisha-Fregoso Y, Guerra E, Adrover M, Lage Santos AJ, Catalán-Pellet A Abstract OBJECTIVES: To assess the use of antimalarials and to evaluate their association with damage accrual in a Latino-American cohort of patients with primary Sjögren's syndrome (pSS). METHODS: We included 377 patients attending three tertiary referral centers from: Argentina (n=110), Brazil (...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Strong correlation between cancer progression and anti-transcription intermediary factor 1 γ antibodies in dermatomyositis patients.
This study aims to identify the clinical characteristics of cancers in anti-ΤΙF1γ antibody-positive adult patients with DM. METHODS: This retrospective analysis covered 160 adult DM patients who visited Nagoya University Hospital or collaborating medical centres between 2003 and 2016. Anti-TIF1γ antibody and other myositis-specific autoantibodies were detected by ELISA. Based on a review of medical charts, the cancers were staged according to the TNM Classification of Malignant Tumours of the Union for International Cancer Control and were divided into the two groups of "advanced" or &quo...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Interstitial lung disease in patients with mixed connective tissue disease: pilot study on predictors of lung involvement.
Authors: Narula N, Narula T, Mira-Avendano I, Wang B, Abril A Abstract OBJECTIVES: Mixed connective tissue disease (MCTD) is an immune-mediated systemic disorder characterised by serum autoantibodies against U1-ribonucleoprotein and diverse multisystemic clinical manifestations. Approximately 50% of patients with MCTD develop a radiologic pattern of interstitial lung disease (ILD). Our single centre, cross-sectional study sought to identify clinical and serologic associations of ILD in patients with MCTD which may serve as predictors of lung disease and prognosis. METHODS: Patients who met validated criteria fo...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The presence of staphylococcal superantigens in nasal swabs and correlation with activity of granulomatosis with polyangiitis in own material.
Authors: Fijołek J, Wiatr E, Petroniec V, Augustynowicz-Kopec E, Bednarek M, Gawryluk D, Martusewicz-Boros MM, Modrzewska K, Radzikowska E, Roszkowski-Sliz K Abstract OBJECTIVES: Nasal carriage of Staphylococcus aureus and its superantigens (SAg) seem to be a risk factor disease exacerbation in granulomatosis with polyangiitis (GPA). We investigated the association between the presence of SAg in nasal swabs and activity of disease in GPA patients also taking into account correlation with an antimicrobial treatment. METHODS: In a prospective study of a total of 150 GPA patients hospitalised in the period 2009-2...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A case of giant cell arteritis mimicking vertebral dissection on contrast-enhanced magnetic resonance angiography.
Authors: Yashima A, Yamashita H, Yamada S, Noguchi T, Takahashi Y, Kaneko H PMID: 29745877 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Should over-treatment of axial spondyloarthritis with biologics remain a concern after the issue of the new ASAS criteria? Data from REGISPONSERBIO (Spanish Register of Biological Therapy in Spondyloarthritides).
Authors: Moreno M, Gratacós J, Navarro-Compán V, de Miguel E, Font P, Clavaguera T, Linares LF, Joven B, Juanola X, and the Regisponserbio group. Abstract OBJECTIVES: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria. METHODS: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment s...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tapering tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective study.
Authors: Hacioglu A, Hatemi G, Esatoglu SN, Hamuryudan V PMID: 29745879 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of auditory evoked potentials and otoacoustic emissions in early detection of hearing abnormalities in Beh çet's disease patients. A case control study.
CONCLUSIONS: Being one of the autoimmune inner ear diseases (AIED), BD has a definite hearing impairment, even in the presence of normal hearing sensitivity, as evidenced by PTA. BD patients had a sub-clinical cochlear pathology which was not affected by disease activity or different organ affection. DPOAE (S/N ratio) proved to be a sensitive test in detecting minimal changes in cochlear pathology and the latencies of CAEPs (tone and speech) measures were considered as sensitive indicators (100%) of early detection of hearing impairment in BD patients. PMID: 29745880 [PubMed - as supplied by publisher] (Source: Clinica...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Catastrophic multiple arterial dissections revealing concomitant polyarteritis nodosa and vascular Elhers-Danlos syndrome.
Authors: Caudrelier L, Pugnet G, Astudillo L, Delbrel X, Bura Riviere A, Sailler L PMID: 29745881 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The adenosinergic system: a potential player in the pathogenesis of ANCA-associated vasculitis?
Authors: Kling L, Krämer BK, Yard BA, Kälsch AI Abstract Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially lethal autoimmune disease whose pathology comprises disturbed T cell differentiation and functionality accompanied by dysfunctional autoreactive immunoglobulin development, culminating in destructive innate immune response as well. Purines, adenine nucleotides and adenosine in particular, have been elucidated as potent extracellular mediators for fine adjustment of these pivotal processes establishing human immunity. Therefore, the extracellular purinergic microe...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence and characteristics associated with dactylitis in patients with early spondyloarthritis: results from the ESPeranza cohort.
Authors: Tévar-Sánchez MI, Navarro-Compán V, Aznar JJ, Linares LF, Castro MC, De Miguel E, ESPERANZA Group. Abstract OBJECTIVES: Dactylitis is a typical feature of psoriatic arthritis. However, dactylitis was included as a spondyloarthritis (SpA) feature for both (axial and peripheral) of the ASAS classification criteria, but data about its prevalence are scarce, especially in patients with a recent onset of the disease. Our objective was to determine the prevalence and characteristics associated with dactylitis in patients with early SpA. METHODS: A baseline dataset from the ESPeranza coho...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis.
Authors: Gudmann NS, Junker P, Juhl P, Thudium CS, Siebuhr AS, Byrjalsen I, Karsdal MA, Bay-Jensen AC Abstract OBJECTIVES: The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting pathobiologic processes. Type IV collagen is an abundant protein of basement membranes, but is also present in the intercellular matrix of the synovial lining layer. We aimed to investigate the association of type IV collagen turnover with RA disease activity, response to IL-6 inhibition and radiographic progression. METHODS: C4M, a s...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Explorative analyses of protein biomarkers in patients with early rheumatoid arthritis achieving sustained drug-free remission after treatment with tocilizumab- or methotrexate-based strategies: from transcriptomics to proteomics.
CONCLUSIONS: Multiple proteins were associated with achieving sDFR and several biological pathways corresponded, mainly in the methotrexate arm, with our previous transcriptomic findings potentially providing further insights into gene expression and protein translation in newly diagnosed RA patients. PMID: 29745885 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Primary myelofibrosis but not autoimmune myelofibrosis accompanied by Sj ögren's syndrome and primary biliary cirrhosis in a patient with trisomy 8 mosaic: a case report and literature review.
Primary myelofibrosis but not autoimmune myelofibrosis accompanied by Sjögren's syndrome and primary biliary cirrhosis in a patient with trisomy 8 mosaic: a case report and literature review. Clin Exp Rheumatol. 2018 May 10; Authors: Lu C, Wu X, Wen H, Gao H, Wang C, Yang B, Liang Z, Gao C, Li X Abstract Bone marrow fibrosis has been found to be associated with autoimmune disorders, and autoimmune myelofibrosis (AIMF) has been defined. Primary myelofibrosis (PMF), a clonal myeloproliferative disorder, should be distinguished from AIMF which has a good response to steroids, as the former has a high...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Successful treatment of a patient with both systemic lupus erythematosus and progressive hepatitis C using immunosuppressive therapy and interferon beta.
Authors: Sugimori Y, Yamashita H, Yorifuji H, Takahashi Y, Kaneko H, Mimori A PMID: 29745887 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Survival of connective tissue disease associated pulmonary arterial hypertension.
Authors: Luppino Assad AP, Gavilanes Oleas F, Alves JL, Dos Santos Fernandes CJC, Sampaio-Barros PD, Souza R PMID: 29745888 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Potentially traumatic events, PTSD and post-traumatic stress spectrum in patients with fibromyalgia.
CONCLUSIONS: The results of the study show that fibromyalgic patients with PTSD report more potentially traumatic events, avoidance symptoms, numbing, arousal, maladaptive coping and personality characteristics compared to patients with partial or without PTSD; these results could indicate that loss and/or trauma events represent a risk factor for the development of symptoms of FM in genetically predisposed individuals. PMID: 29745889 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pattern of muscle involvement in inclusion body myositis: a sonographic study.
CONCLUSIONS: Ultrasonography can aid in the assessment of IBM by displaying an increased echointensity in characteristically involved muscles, particularly when combined with assessments for asymmetry and echotexture. PMID: 29745890 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Helicobacter pylori infection in systemic sclerosis: a systematic review and meta-analysis of observational studies.
Authors: Yong WC, Upala S, Sanguankeo A Abstract OBJECTIVES: It has been proposed that Helicobacter pylori (H.pylori) infection causes several extra-gastrointestinal disorders. However, the role of H.pylori infection in the pathogenesis of systemic sclerosis (SSc) is still debatable. This meta-analysis is aimed at exploring the association between SSc and H.pylori infection. METHODS: A comprehensive search of the MEDLINE and EMBASE databases was performed from inception through February 2018. The inclusion criterion was observational studies evaluating H.pylori infection in SSc. The pooled odds ratio (OR) of H....
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Peripheral CD4+CD28null T-cells as predictors of damage in  systemic lupus erythematosus patients.
CONCLUSIONS: In SLE patients, CD4+CD28null T-cells predict the occurrence of new lung damage, independently of other risk factors but not of overall damage or damage on other domains. PMID: 29745892 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cell therapies for refractory rheumatoid arthritis.
Authors: Liu R, Zhao P, Tan W, Zhang M Abstract Rheumatoid arthritis (RA), an autoimmune disease, is characterised by a persistent synovitis in the joints and systemic inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and disease-modifying antirheumatic drugs (DMARDs) are widely used to treat RA patients. However, a portion of patients still have inadequate response to traditional medications. Recently, cell-based therapies have become the focus, attracting more attention due to their potential for remission induction. Several immune-regulatory cell types, such as haematopoietic stem cel...
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between dietary and metabolic factors and IgM antibodies to phosphorylcholine and malondialdehyde in patients with systemic lupus erythematosus and population-based matched controls.
CONCLUSIONS: Some dietary and metabolic factors were associated with IgM anti-PC and anti-MDA, though it is not clear whether the associations also represent causation. PMID: 29745894 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Updated overview of molecular pathways involved in the most common monogenic autoinflammatory diseases.
Authors: Lucherini OM, Rigante D, Sota J, Fabiani C, Obici L, Cattalini M, Gattorno M, Cantarini L Abstract An apparently unprovoked recurrent inflammation is the quintessential hallmark of autoinflammatory diseases (AIDs), a large and heterogeneous group of disorders in which there is poor regulation of the innate immune system with no clearly demonstrated autoimmune machinery involvement. Innate immunity pathways are diverse and our understanding of their molecular composition and function is continuously expanding. The impaired immune responses we observe in monogenic AIDs, mostly in the hereditary periodic feve...
Source: Clinical and Experimental Rheumatology - May 11, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Overview of fever of unknown origin in adult and paediatric patients.
Authors: Attard L, Tadolini M, De Rose DU, Cattalini M Abstract Fever of unknown origin (FUO) can be caused by a wide group of diseases, and can include both benign and serious conditions. Since the first definition of FUO in the early 1960's, several updates to the definition, diagnostic and therapeutic approaches have been proposed. This review outlines a case report of an elderly Italian male patient with high fever and migrating arthralgia who underwent many procedures and treatments before a final diagnosis of Adult-onset Still's disease was achieved. This case report highlights the difficulties in diagnosing ...
Source: Clinical and Experimental Rheumatology - May 11, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research