Hyperlipoprotein(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project.
CONCLUSIONS: SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients. PMID: 30789151 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment.
CONCLUSIONS: By targeting both ICOSL and BAFF, AMG 570 has the potential to achieve superior efficacy in treatment of autoimmune diseases such as SLE and rheumatoid arthritis. PMID: 30789152 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Innate lymphoid cells are increased in systemic lupus erythematosus.
Authors: Hou M, Liu S Abstract OBJECTIVES: Innate lymphoid cells (ILCs) are emerging mediators of immunity and accumulation of inflammatory ILC populations can occur in inflammatory-mediated conditions. We aimed to examine the proportion of different subgroups of ILCs in the peripheral blood of patients with systemic lupus erythematosus (SLE) to evaluate the pathogenesis of SLE. METHODS: Peripheral blood mononuclear cells were collected from 51 SLE patients and 26 healthy controls. Subpopulations of ILCs were analysed by flow cytometry. RESULTS: Compared with the control group, ILCs (Lin-CD127+CD45+ cells) ...
Source: Clinical and Experimental Rheumatology - February 24, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ba-Duan-Jin alleviates pain and fibromyalgia-related symptoms in patients with fibromyalgia: results of a randomised controlled trial.
Authors: Jiao J, Russell IJ, Wang W, Wang J, Zhao YY, Jiang Q Abstract OBJECTIVES: Fibromyalgia is a chronic debilitating pain syndrome. There has been growing interest in the development of non-pharmacological therapies. Ba-Duan-Jin is an ancient Chinese exercise for health promotion, yet easy to learn. The purpose of this study is to evaluate the effectiveness of Ba-Duan-Jin in managing fibromyalgia symptoms experienced by Chinese patients. METHODS: In this randomised, usual therapy-controlled study, patients with fibromyalgia practiced Ba-Duan-Jin for one hour, twice a week for 12 weeks. The primary outcome ...
Source: Clinical and Experimental Rheumatology - February 24, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

What are the main barriers to achieve minimal disease activity in psoriatic arthritis in real life?
CONCLUSIONS: The MDA criteria provide an objective target for treatment in trials and clinical practice; however, in real life PROs are the most significant barriers to achieve MDA. The presence of DIP joints disease makes it difficult to reach MDA due to active PROs. PMID: 30767863 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The effect of JAK1/JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib.
Authors: Choy EHS, Miceli-Richard C, González-Gay MA, Sinigaglia L, Schlichting DE, Meszaros G, de la Torre I, Schulze-Koops H Abstract Numerous cytokines have been implicated in the pathogenesis of inflammatory diseases, and their dysregulation is a main feature of rheumatoid arthritis (RA). Cytokines stimulate signal transduction through several intracellular pathways, including Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathways, leading to changes in cell activation, proliferation and survival. Consequently, agents that selectively target elements of the JAK/STAT pathway...
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rate of serious infections in spondyloarthropathy patients treated with anti-tumour necrosis factor drugs: a survey from the Italian registry GISEA.
Authors: Atzeni F, Sarzi-Puttini P, Sebastiani M, Panetta V, Salaffi F, Iannone F, Carletto A, Foti R, Gremese E, Govoni M, Marchesoni A, Favalli E, Gorla R, Ramonda R, Ferraccioli G, Lapadula G, GISEA group. Abstract OBJECTIVES: To determine the incidence of serious infections (SIs) among the spondyloarthropathy (SpA) patients from the "Gruppo Italiano per lo Studio delle Early Arthritis" (GISEA) registry and treated with tumour necrosis factor (TNF) inhibitors (TNFIs), and to identify the factors associated with the development of the infections. METHODS: This observational study on 3321 GISEA-regis...
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical features of thirty-two patients with anti-melanoma differentiation-associated gene 5 antibodies.
CONCLUSIONS: Anti-MDA5 antibodies are closely related to interstitial lung disease (ILD). The presence of both anti-MDA5 and anti-Ro52 antibodies indicates poor prognosis. PMID: 30767866 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

IL-35 prevent bone loss through promotion of bone formation and angiogenesis in rheumatoid arthritis.
CONCLUSIONS: These results suggested that IL-35 promotes bone formation and angiogenesis by fostering osteoblasts proliferation, inhibiting apoptosis and upregulating pro-angiogenic molecules through Th17/IL-17 related-signalling pathway. Our findings extend the current understanding of mechanisms modulating bone formation and angiogenesis in RA. PMID: 30767867 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide.
CONCLUSIONS: Among the csDMARDs, leflunomide can be beneficial in lumbar spine BMD in RA patients with osteoporosis. PMID: 30767868 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study.
Authors: Li C, Zhao Y, Zuo Y, Zhou Y, Zhang F, Liu S, Zhu Q, Chen J, Zhang W, Xu W, Gu Z, Li L, Li F, Tao W, Cao Y, Sun X, Jing H, Chen H, Zhang S, Dong Z, Liu J, Shi X, Hao W, Qiu G, Zhang W, Wu N, Wu Z Abstract OBJECTIVES: To evaluate the clinical efficacy of bisphosphonates treatment for spinal bone marrow oedema (BME) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. METHODS: SAPHO syndrome patients presenting to Peking Union Medical College Hospital from 2015 to 2016 were recruited. Patients were administered pamidronate disodium 1 mg/kg/d intravenously, for 3 days,...
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A probability score to aid the diagnosis of suspected giant cell arteritis.
CONCLUSIONS: The GCA Probability Score is a promising and feasible tool for risk stratification of patients referred by general practitioners with suspected GCA. In a fast track clinic setting this aids exclusion of GCA in low probability cases and confirmation of disease in high probability disease. Refinement and subsequent external validation of this score is required. PMID: 30767870 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Adult-onset Still's disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse.
Authors: Takakuwa Y, Hanaoka H, Kiyokawa T, Iida H, Ishimori K, Uekusa T, Yamada H, Kawahata K Abstract OBJECTIVES: Adult-onset Still's disease (AOSD) is an inflammatory disorder characterised by sustained fevers, arthritis, and skin involvement. Interstitial lung disease (ILD) is a rare manifestation, and its clinical characteristics have yet to be determined. METHODS: We sought to examine the clinical characteristics of AOSD-associated ILD. We retrospectively investigated 78 patients diagnosed as AOSD. ILD was diagnosed based on chest high-resolution computed tomography (HRCT). Clinical characteristics were c...
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Anti-myeloperoxidase antibody positivity in patients without primary systemic vasculitis.
CONCLUSIONS: The high incidence of MPO-ANCA positivity in patients with non-vasculitic conditions highlights the need for careful clinical correlation and confirmatory tissue diagnosis. PMID: 30767872 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical features of systemic sclerosis patients with anti-RNA polymerase III antibody in a single centre in Spain.
Authors: Callejas-Moraga EL, Guillén-Del-Castillo A, Marín-Sánchez AM, Roca-Herrera M, Balada E, Tolosa-Vilella C, Fonollosa-Pla V, Simeón-Aznar CP Abstract OBJECTIVES: To evaluate the clinical features and survival of patients with positive anti-RNA polymerase III (anti-RNAP III) in a Spanish single centre. METHODS: We analysed 221 patients with SSc according to LeRoy and Medsger criteria. Twenty-six patients with positivity for anti-RNAP III antibodies were compared with 195 negative patients. Epidemiological, clinical, immunological features and survival were analysed. RESULTS...
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.
CONCLUSIONS: Ex-vivo inhibition of cytokine production by bDMARDs is unable to help prediction of treatment response to bDMARDs in RA. PMID: 30767874 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.
CONCLUSIONS: Neutrophil-derived LTF may play a role as an endogenous ligand for TLR4 expressed on RASFs. NFAT5-NF-κB enhanceosome might regulate the expressions of LTF-TLR4-responsive genes in RASFs. PMID: 30767875 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Metabolites of C-reactive protein and vimentin are associated with disease activity of axial spondyloarthritis.
Authors: Siebuhr AS, Hušaková M, Forejtová S, Zegzulková K, Tomčik M, Urbanová M, Grobelná K, Gatterová J, Bay-Jensen AC, Pavelka K Abstract OBJECTIVES: Non-radiographic (nr-axSpA) and radiographic (AS) forms of axial spondyloarthritis (axSpA) share clinical features, but have different radiographic patterns. Radiographic progression is not associated with the current disease activity biomarkers. We investigated a matrix metalloproteinase mediated metabolite of C-reactive protein (CRPM) and two biomarkers of citrullinated vimentin (VICM and anti-MCV) as novel biomar...
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The mortality rate and causes of death among juvenile idiopathic arthritis patients in Finland.
Authors: Kyllönen MS, Kautiainen H, Puolakka K, Vähäsalo P Abstract OBJECTIVES: To explore mortality rates and causes of death in juvenile idiopathic arthritis (JIA) patients in Finland compared with the general population. METHODS: All incident patients with JIA (age
Source: Clinical and Experimental Rheumatology - February 17, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia and is modulated by hyperbaric oxygen therapy.
CONCLUSIONS: FM patients show a Th1 signature and the activation of this subset is modulated by HBOT. PMID: 30747094 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of patient organisation in fibromyalgia and related syndromes.
Authors: Gur S, Ablin JN Abstract PMID: 30747095 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Fibromyalgia syndrome: under-, over- and misdiagnosis.
Authors: Häuser W, Sarzi-Puttini P, Fitzcharles MA Abstract Fibromyalgia syndrome (FM) is an enigma. During the past three decades, with the gradual acceptance of the validity of FM, it is variously under-, over and misdiagnosed. Evidence-based interdisciplinary guidelines have suggested a comprehensive clinical assessment to avoid this diagnostic conundrum. Every patient with chronic pain should be screened for chronic widespread pain (pain in four of five body regions) (CWP). Those with CWP should be screened for presence of additional major symptoms of FM: unrefreshed sleep and fatigue. A complete medical (...
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2019: fibromyalgia.
Authors: Atzeni F, Talotta R, Masala IF, Giacomelli C, Conversano C, Nucera V, Lucchino B, Iannuccelli C, Di Franco M, Bazzichi L Abstract Fibromyalgia is characterised by chronic pain, fatigue and functional symptoms. Its aetiopathogenesis is still a matter of debate, but various pharmacological and non-pharmacological therapies are currently available for its treatment. We review the literature concerning the most recent findings related to the aetiopathogenesis, diagnosis, clinical aspects and treatment of FM published between January 2018 and January 2019. PMID: 30747097 [PubMed - in process] (Source: Clini...
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Fibromyalgia and the concept of resilience.
Authors: Casale R, Sarzi-Puttini P, Botto R, Alciati A, Batticciotto A, Marotto D, Torta R Abstract The concept of resilience varies according to the context in which it is used. Resilience is broadly defined as a protective factor that makes people less vulnerable to future adverse life events, in this implying the previous occurrence of an adverse event that has to be confronted before individual equilibrium can be restored. This definition can be applied to fibromyalgia and other chronic pain situations. Resilience is profoundly related to reaction to acute or chronic stress, and is therefore involved in the str...
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hyperbaric oxygen treatment of fibromyalgia: a prospective observational clinical study.
CONCLUSIONS: These findings support the view that HBOT is an effective, rapid and safe means of treating various symptoms of FM. PMID: 30747099 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: looking inside muscles by means of surface electromyography.
CONCLUSIONS: HBOT did not improve muscle strength or change muscle fibre content, but improved the ability of the central motor command to generate the same effort (MVC) with fewer recruited fibres. Our sEMG findings underlined a modified central mechanism related to fibre type recruitment order, thus suggesting that muscle fatigue is not primarily a muscular problem, as also demonstrated by other authors with different methods. PMID: 30747100 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A psychoeducational intervention is a treatment for fibromyalgia syndrome.
Authors: Conversano C, Poli A, Ciacchini R, Hitchcott P, Bazzichi L, Gemignani A Abstract Although the mechanisms underlying fibromyalgia are not yet clear, many attempts have been made to implement pharmacological therapy and help patients manage its psychological and physical symptoms. Recent evidence has shown that an interdisciplinary multidimensional approach encompassing psychological factors, emotion regulation strategies and education on illness is more effective in improving quality of life, both in the short- and long-term, than usual treatments alone. The purpose of this review is to provide an updated o...
Source: Clinical and Experimental Rheumatology - February 14, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Current and early life weight and associations with mortality in rheumatoid arthritis.
This study evaluated the impact of weight early in life and weight loss on mortality in patients with RA. METHODS: Patients with RA (age>40 years) were active participants in a prospective clinical registry with up to 17 years of follow-up. Current and age-30 body mass index (BMI) were determined from self-report of height and weight from semi-annual questionnaires. Mortality was assessed from National Death Index. Risks of obesity reported from both early in life and at enrolment in the registry were evaluated using Cox proportional hazards models. RESULTS: Among 12,679 participants (80% female), there were 1,5...
Source: Clinical and Experimental Rheumatology - February 7, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy of anti-tumour necrosis factor- α monoclonal antibodies in patients with non-infectious anterior uveitis.
Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis. Clin Exp Rheumatol. 2019 Jan 18; Authors: Fabiani C, Vitale A, Rigante D, Emmi G, Lopalco G, Sota J, Vannozzi L, Guerriero S, Bitossi A, Orlando I, Franceschini R, Frediani B, Galeazzi M, Iannone F, Tosi GM, Cantarini L Abstract OBJECTIVES: To assess the efficacy of monoclonal anti-tumour necrosis factor (TNF)-α agents in patients with anterior uveitis (AU) in terms of decrease of recurrences, variation of visual acuity and steroid sparing effect and to identify any demographic,...
Source: Clinical and Experimental Rheumatology - February 7, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

S100A11 (calgizzarin) is released by circulating mononuclear cells and its elevated plasma levels distinguish systemic lupus erythematosus patients from healthy individuals.
Authors: Cerezo LA, Šumová B, Hulejová H, Štorkánová H, Szczuková L, Tomčík M, Bečvář R, Pavelka K, Vencovský J, Závada J, Šenolt L Abstract PMID: 30719969 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 7, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased expression levels of Fc γRIIB on naïve and double-negative memory B cells in patients with systemic sclerosis.
Increased expression levels of FcγRIIB on naïve and double-negative memory B cells in patients with systemic sclerosis. Clin Exp Rheumatol. 2019 Jan 17; Authors: Yagi-Numata N, Matsushita T, Takehara K, Hamaguchi Y Abstract OBJECTIVES: In systemic sclerosis (SSc), B cell hyperactivation and abnormality are considered to play an important role in the disease pathophysiology. We aimed to clarify if the abnormal activation of B cells involves inhibitory FcγRIIB on B cells in SSc patients. METHODS: Blood samples were collected from 76 SSc patients (38 limited cutaneous SSc and 38 diffu...
Source: Clinical and Experimental Rheumatology - February 7, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum cytokine and chemokine levels in patients with eosinophilic granulomatosis with polyangiitis, hypereosinophilic syndrome, or eosinophilic asthma.
Authors: Pagnoux C, Nair P, Xi Y, Khalidi NA, Carette S, Cuthbertson D, Grayson PC, Koening CL, Langford CA, McAlear CA, Moreland LW, Monach PA, Seo P, Specks U, Sreih AG, Ytterberg SR, Tyrrell PN, Merkel PA, Vasculitis Clinical Research Consortium Abstract OBJECTIVES: The pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) remains poorly understood, and may overlap with eosinophilic asthma and primary hypereosinophilic syndrome (HES). The aim of this study was to analyse a panel of serum cytokines and chemokines as markers of disease activity in patients with these conditions. METHODS: The lev...
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Insulin resistance vary across connective tissue diseases patients: comparison between rheumatoid arthritis, systemic lupus erythematosus and systemic sclerosis.
Authors: Kotyla PJ Abstract PMID: 30652676 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Effects of glucocorticoids on B-cell subpopulations in patients with IgG4-related disease.
CONCLUSIONS: The efficacy of glucocorticoids in IgG4-RD is associated with selective effects on different B-cell subpopulations. Further studies are warranted to fully understand possible perturbations of the naïve and memory B-cell compartments in patients with IgG4-RD. PMID: 30652677 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Evaluation of salivary and plasma microRNA expression in patients with Sj ögren's syndrome, and correlations with clinical and ultrasonographic outcomes.
CONCLUSIONS: Our data show that salivary mi146a may represent a marker of the disease, and that the expression of salivary miR17, 18a and 146b may be altered in patients with pSS, and associated with worse ultrasound and ESSPRI scores and anti-La/SSB positivity. PMID: 30652678 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

High prevalence of fibromyalgia among Israeli school teachers.
CONCLUSIONS: Fibromyalgia symptoms are highly prevalent among Israeli school teachers, and may be related to stress encountered in the classroom. These results are relevant both for physicians treating individuals involved in educational careers as well as for educators and decision-makers involved in planning and managing educational strategies. PMID: 30652679 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Brain responses to other people's pain in fibromyalgia: a magnetoencephalography (MEG) study.
CONCLUSIONS: Consistent with previous findings, healthy participants displayed stronger alpha desynchronisation for pain pictures, indicating automatic disinhibition of the sensorimotor cortices in response to the observation of pain in others. We found evidence for a deficient modulation of sensorimotor cortex in FM patients. The lack of differential response suggests that they perceived relatively neutral pictures as potentially painful, at least in this setting. Our findings suggest that defective top-down regulation may play a role in the pathogenesis of FM. PMID: 30652680 [PubMed - as supplied by publisher] (Sourc...
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6.
CONCLUSIONS: The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc. PMID: 30652681 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Occurrence and aetiology of gastrointestinal perforation in patients with vasculitis.
CONCLUSIONS: Small bowel location and longer abdominal pain duration may help distinguish vasculitis-induced bowel perforation from other etiologies. Overall mortality in patients with vasculitis and bowel perforation is increased, highlighting the importance of prompt diagnosis and management. PMID: 30652682 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 19, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Acute anterior uveitis in spondyloarthritis: a monocentric study of 301 patients.
CONCLUSIONS: Prevalence of uveitis in SpA seems to increase with disease duration and seems more likely to appear with HLA B27 positivity and heel pain. Anti-TNF monoclonal antibodies seemed to be more effective in the reduction of uveitis flares. PMID: 30620268 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study.
CONCLUSIONS: Our findings suggest that US can be used to diagnose/examine subjects in adulthood for pathological changes in the entheses; however, caution should be taken regarding enthesophytes of the quadriceps and Achilles tendon. PMID: 30620269 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Performance of 18F-sodium fluoride positron emission tomography with computed tomography to assess inflammatory and structural sacroiliitis on magnetic resonance imaging in axial spondyloarthritis.
CONCLUSIONS: Abnormal uptake by the SIJ on 18F-NaF PET is more frequent (87.0%) than inflammatory (43.5%) and structural sacroiliitis (65.2%) on MRI in a population of SpA patients. The PET activity score and SUVmax had good correlations with inflammatory sacroiliitis but not with structural lesions on MRI. PMID: 30620270 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Fibroblast-like synoviocytes from fluid and synovial membrane from primary osteoarthritis demonstrate similar production of interleukin 6, and metalloproteinases 1 and 3.
The objective of the study was to compare the production of metalloproteinases (MMP)-1, -3 and interleukin (IL)-6 by fibroblast-like synoviocytes (FLS) derived from synovial fluid (FD-FLS), and FLS derived from synovial tissue (TD-FLS) of patients with primary osteoarthritis (OA). The more accessible FD-FLS could facilitate the study of the role of these cells in OA pathophysiology. METHODS: MMP-1, MMP-3, and IL-6 levels were measured in the supernatant culture at baseline and 22 hours after stimulation with TNF-α and IL-1 β. RESULTS: There was no difference at baseline between MMP-1, MMP-3 and IL-6 prod...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between STAT4 polymorphisms and the risk of juvenile idiopathic arthritis in Han Chinese populations.
CONCLUSIONS: The G allele of rs11893432 was significantly associated with JIA risk, particularly oligoarticular JIA, in Han Chinese populations. SNPs at rs1018981 and rs10931481 were correlated with higher risk of polyarticular JIA. PMID: 30620272 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical peripheral enthesitis in the DESIR prospective longitudinal axial spondyloarthritis cohort.
CONCLUSIONS: This study highlights the high prevalence of peripheral enthesitis in recent onset axial spondyloarthritis, and suggests that in combination with peripheral arthritis, enthesitis might have an impact on the burden of the disease. PMID: 30620273 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System.
Authors: Gokoffski KK, Chatterjee A, Khaderi SK Abstract OBJECTIVES: Giant cell arteritis (GCA) is a vasculitis that affects large and medium sized arteries. The aetiology of GCA is unknown and numerous risk factors have been proposed. In this article, we evaluate the incidence of biopsy-positive GCA in Northern California and assess for seasonal variation. METHODS: We performed a retrospective review based on billing codes of temporal artery biopsies performed at the University of California, Davis from 2003 to 2014. RESULTS: We identified 174 biopsies (119 female, 55 male). Of these, 21 positive biopsies ...
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: gout.
This article reviews the new clinical and experimental evidence about gout that emerged in 2017 and in the first half of 2018. PMID: 30620275 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Global metabolomic profiling of human synovial fluid for rheumatoid arthritis biomarkers.
CONCLUSIONS: This study supports the use of global metabolomic profiling by liquid chromatography-mass spectrometry for synovial fluid analysis to provide insight into the aetiology of disease. PMID: 30620276 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Early onset, non-rheumatic, group A streptococcal-associated myocarditis.
CONCLUSIONS: Non-RF GAS myocarditis typically affects healthy young males and represents about 3% of all hospitalised patients with myocarditis. These patients may be mistakenly diagnosed with an acute rheumatic fever or myocardial infarction. The prognosis in generally good following treatment with antibiotics and possibly NSAIDs. PMID: 30620277 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Choline metabolite, trimethylamine N-oxide (TMAO), is associated with inflammation in psoriatic arthritis.
CONCLUSIONS: In our cohort, only TMAO, but not TMA, choline, betaine or carnitine, was associated with inflammation in PsA patients, establishing a mechanistic link between TMAO and PsA phenotypes. Future studies will explore the modulation of TMAO and disease severity in PsA. PMID: 30620278 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research