Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank

CONCLUSIONS: Our study evaluates the performance of real-world identification of anti-synthetase antibodies in a large cohort of multi-national patients with ASSD and controls. Our analysis reinforces the reliability of real-world anti-Jo1 detection methods. In contrast, challenges persist for anti-non-Jo1 identification, particularly anti-PL7 and rarer antibodies such as anti-OJ/KS. Clinicians should exercise caution when interpreting anti-synthetase antibodies, especially when commercial immunoassays test positive for non-anti-Jo1 antibodies.PMID:38488094 | DOI:10.55563/clinexprheumatol/s14zq8

Source: Clinical and Experimental Rheumatology - March 15, 2024 Category: Rheumatology Authors: Aravinthan Loganathan Giovanni Zanframundo Akira Yoshida Sara Faghihi-Kashani Iazsmin Bauer Ventura Eduardo Dourado Francisca Bozan Gianluca Sambataro Yasuhiko Yamano Sharon Sangmee Bae Darosa Lim Angela Ceribelli Natasa Isailovic Carlo Selmi Noreen Ferti Source Type: research