The evaluation of disease activity in Sj ögren's syndrome based on the degree of MALT involvement: glandular swelling and cryoglobulinaemia compared to ESSDAI in a cohort study.
CONCLUSIONS: The autoimmune and lymphoproliferative involvement of MALT is the biological substrate of pSS. If this involvement is heavier, as reflected by SG swelling and cryoglobulinaemia, disease activity may be considered higher, and the risk of lymphoma is increased. The current concept and evaluation of activity of pSS, based solely on the ESSDAI, needs revision. PMID: 30156548 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Artificial neural networks help to identify disease subsets and to predict lymphoma in primary Sj ögren's syndrome.
CONCLUSIONS: Our study has shed new light on the possibility of using novel tools to extract hidden, previously unknown and potentially useful information in complex diseases like pSS, facing the challenge of disease phenotyping as a prerequisite for discovering novel specific biomarkers and new therapeutic targets. PMID: 30156549 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of salivary gland histopathology in primary Sj ögren's syndrome: promises and pitfalls.
The role of salivary gland histopathology in primary Sjögren's syndrome: promises and pitfalls. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):222-233 Authors: Kroese FGM, Haacke EA, Bombardieri M Abstract The formation of lymphomononuclear cell infiltrates organising as periductal infiltrates in the salivary glands of patients with primary Sjögren's syndrome (pSS) is one of the hallmarks of the disease. Historically, the clinical role of salivary gland histopathology, most commonly performed on labial salivary gland biopsies, has been confined to the clinical classification and diagnosis o...
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

14th International Symposium on Sj ögren's Syndrome.
14th International Symposium on Sjögren's Syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):241-255 Authors: Baer AN, Akpek EK, Alevizos I, 18-21 April 2018, Washington, DC, USA PMID: 30156551 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Poster presentations.
Authors: PMID: 30156552 [PubMed] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Severe cutaneous hand infection: Mycobacterium marinum in an immunosuppressed patient.
Authors: Argyropoulou OD, Zampeli E, Sipsas NV, Tzioufas AG, Moutsopoulos HM PMID: 30148427 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis?
CONCLUSIONS: Autoantibodies only partially contribute to risk-stratification and clinical subsetting in SSc. The current findings confirm that not all ATA-positive patients have worse prognosis and as such, additional biomarkers are needed to guide clinical follow-up in SSc. PMID: 30148428 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hyper-IgD syndrome in a patient with IgA immunodeficiency.
Authors: Smerla RG, Agrafiotou C, Fragoulis GE PMID: 30148429 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Intra-articular 2.5% polyacrylamide hydrogel for the treatment of knee osteoarthritis: an observational proof-of-concept cohort study.
Authors: Henriksen M, Overgaard A, Hartkopp A, Bliddal H Abstract OBJECTIVES: There is a drought of effective treatments of knee osteoarthritis (OA) and new therapies are needed. The present study has been conducted to establish an initial estimate of effectiveness of intra-articular (IA) injection of a proprietary 2.5% cross-linked polyacrylamide hydrogel (PAAG) for the treatment of knee OA symptoms and signs. METHODS: Patients with knee OA were invited into a prospective open-label cohort study. The patients received up to two IA injections of 3 ml of PAAG 1 month apart. The WOMAC questionnaire was used to es...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study.
CONCLUSIONS: Supervised exercise training did not impair disease status and seemed to be feasible, safe and effective in patients with IMNM. Moreover, exercise training increased aerobic capacity, muscle strength and function, suggesting that this could be a novel potential coadjuvant therapy in IMNM. PMID: 30148431 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A randomised, double-blind, placebo-controlled study assessing the efficacy of high doses of vitamin D on functional disability in patients with rheumatoid arthritis.
Authors: Soubrier M, Lambert C, Combe B, Gaudin P, Thierry T, Sibilia J, Dougados M, Dubost JJ Abstract OBJECTIVES: To evaluate the short-term efficacy of vitamin D (cholecalciferol) supplementation on functional disability in RA patients. METHODS: 1) Patients: RA (ACR 1987 revised criteria) in non-remission (DAS28>2.6) whose treatment was not expected to be changed over a 3-month period following inclusion and presenting with vitD deficits (serum 25OHD
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A combination model to predict relapse and successful conventional DMARDs de-escalation in rheumatoid arthritis patients with sustained clinical remission.
CONCLUSIONS: De-escalation therapy was associated with higher risk of relapse in RA patients with sustained clinical remission. A combination model of DAS28(CRP)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical and quality of life improvements with golimumab or infliximab in a real-life ankylosing spondylitis population: the QUO-VADIS study.
Authors: Van den Bosch F, Flipo RM, Braun J, Vastesaeger N, Kachroo S, Govoni M Abstract OBJECTIVES: The QUO VADIS study evaluated disease activity and health-related quality-of-life (HRQoL) in ankylosing spondylitis (AS) patients treated with golimumab (GLM) or infliximab (IFX, originator) during routine clinical care. METHODS: This prospective observational study followed biologics-naïve AS patients newly treated with GLM or IFX for 6 months. Disease activity (BASDAI, BASFI, ASAS, and ASDAS) and HRQoL improvement (≥5 points of SF-36 Physical Component Summary [PCS] score; PCS response) were measured. ...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Methotrexate did not improve endothelial function in rheumatoid arthritis: a study in rats with adjuvant-induced arthritis.
CONCLUSIONS: Despite a reduction of clinical and biological inflammation, methotrexate did not improve endothelial function in AIA rats. Overall data suggest that mechanisms other than the ED reduction are likely involved, and remain to be elucidated to better understand the cardiovascular benefits of methotrexate in rheumatoid arthritis. PMID: 30148435 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Secukinumab provides rapid and persistent relief in pain and fatigue symptoms in patients with ankylosing spondylitis irrespective of baseline C-reactive protein levels or prior tumour necrosis factor inhibitor therapy: 2-year data from the MEASURE 2 study.
Authors: Deodhar A, Conaghan PG, Kvien TK, Strand V, Sherif B, Porter B, Jugl SM, Gandhi KK, MEASURE 2 study group Abstract OBJECTIVES: To evaluate improvement in pain and fatigue in ankylosing spondylitis (AS) patients treated with secukinumab over 2 years (MEASURE 2 study). METHODS: Patients with active AS were randomised to receive secukinumab 150 mg, 75 mg, or placebo weekly until Week 4, and every 4 weeks thereafter. This post hoc analysis included assessment of spinal and nocturnal back pain, FACIT-Fatigue, and association between pain and either FACIT-Fatigue or ASQoL item 5 (sleep quality) for the appro...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Can switching to abatacept therapy in patients with rheumatoid arthritis on background methotrexate reverse TNF-inhibitor-induced antinuclear autoantibody/double-stranded DNA autoantibody conversion? An analysis of the AMPLE and ATTEST trials.
CONCLUSIONS: ANA/anti-dsDNA seroconversion was more frequent with TNFi than abatacept therapy; TNFi-associated seroconversion decreased after switching from TNFi to abatacept. PMID: 30148437 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical features and risk of recurrence of acute calcium pyrophosphate crystal arthritis.
This study compared the clinical features and recurrence rates of both conditions. METHODS: In this retrospective study, we reviewed 106 patients with acute CPP crystal arthritis (based on the presence of CPP crystals and/or chondrocalcinosis) and 173 patients with gout (based on the presence of monosodium urate crystals). We analysed clinical variables and compared them between the two conditions. We identified factors associated with the recurrence of acute CPP crystal arthritis. RESULTS: Patients with acute CPP crystal arthritis were older (76.5 vs. 62 years, p
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Normal sonoanatomy of small joints in healthy children: changes in cartilage and vascularisation according to age and gender.
Authors: Jousse-Joulin S, Cangemi C, Alavi Z, Gerard S, Nonent M, Bressollette L, De Parscau L, Devauchelle-Pensec V, Saraux A Abstract OBJECTIVES: The metacarpophalangeal (MCP) and metatarsophalangeal (MTP) joints may be involved in juvenile idiopathic arthritis. Our goal was to describe their normal sonoanatomy in healthy children, according to age and gender. METHODS: We studied 41 consecutive healthy children (20 girls, 21 boys; age 2-15 years) divided into four age groups: 2-4 years (n=9), 5-7 years (n=11), 8-12 years (n=12), and 13-15 years (n=9). Longitudinal ultrasound axis of the MCP and MTP joints wer...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Risk of hospitalisation for serious bacterial infections in patients with rheumatoid arthritis treated with biologics. Analysis from the RECord linkage On Rheumatic Disease study of the Italian Society for Rheumatology.
CONCLUSIONS: In RA patients treated with bDMARDs, abatacept was associated with the lowest risk of infections; overall risk was mitigated by concomitant methotrexate and increased by glucocorticoids in a dose-dependent manner. PMID: 30148440 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tocilizumab modulates serum levels of adiponectin and chemerin in patients with rheumatoid arthritis: potential cardiovascular protective role of IL-6 inhibition.
CONCLUSIONS: TCZ is able to regulate serum levels of chemerin and adiponectin in RA patients, independently of the disease treatment response, which contributes to explain the CV safety of TCZ. PMID: 30148441 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A misleading case of deficiency of adenosine deaminase 2 (DADA2): the magnifying glass of the scientific knowledge drives the tailored medicine in real life.
Authors: Maccora I, Frongia I, Azzari C, Ricci S, Cimaz R, Simonini G PMID: 30148442 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reduced quality of life impacts knowledge and type of informed consent in rheumatoid arthritis patients.
CONCLUSIONS: Poor quality of life impacts the autonomy of RA patients. PMID: 30148443 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Growth and body mass index in a cohort of patients with juvenile idiopathic arthritis: effects of second line treatments.
CONCLUSIONS: Patients with JIA followed in our centre had a gain of height SDS and lost BMI SDS in 5 years of follow-up. We observed a stable and good pattern of growth in patients treated with DMARDs and an increased growth velocity during biologic treatment. PMID: 30148444 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Immunological signatures in saliva of systemic lupus erythematosus patients: influence of periodontal condition.
CONCLUSIONS: Our findings suggest that long-term therapy with corticoids would contribute with periodontal destruction in SLE patients. Moreover, the increased levels of IL-6, IL-17A and IL-33 in saliva of SLE subjects with CP may signal it as possible inflammatory pathways in this process. PMID: 30148445 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The impact of socioeconomic status on the link between osteoarthritis and the onset of common comorbidities.
Authors: Wilkie R, Kaur K, Hayward RA Abstract OBJECTIVES: The temporal relationship between osteoarthritis and comorbidity is unclear and may vary with socioeconomic status. The aims of this study were to identify if osteoarthritis was associated with onset of common comorbidities, and if the association was moderated by deprivation. METHODS: Prospective cohort study combining questionnaire and medical record data (n=3910). Associations between osteoarthritis and onset of comorbidity at the three-year follow-up were examined using regression models. Interaction terms and stratified analysis were used to examin...
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reciprocal interaction between macrophage migration inhibitory factor and interleukin-8 in gout.
CONCLUSIONS: MIF and IL-8 are highly produced in acute gout. MSU crystals induced MIF production in monocytes and IL-8 production in neutrophils with a reciprocal interaction between the two cytokines. PMID: 30148447 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 28, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2018: ultrasonography in rheumatoid arthritis and psoriatic arthritis.
Authors: Zabotti A, Mandl P, Zampogna G, Dejaco C, Iagnocco A Abstract Ultrasound is playing an increasingly important role in the differential diagnosis and monitoring of rheumatoid arthritis (RA) and psoriatic arthritis (PsA). This technique is more sensitive and specific than clinical examination to detect active synovitis, and the identification of specific synovitis patterns enable differentiation of PsA from RA and other entities. Ultrasound verified inflammation changes along with clinical improvement during therapy, and ultrasound was shown to predict future clinical and structural outcomes thus complementi...
Source: Clinical and Experimental Rheumatology - August 1, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Erratum corrige: "Autologous peripheral blood haematopoietic stem cell transplantation for systemic lupus erythematosus:the observation of long-term outcomes in a Chinese centre". C. Cao et al.
Erratum corrige: "Autologous peripheral blood haematopoietic stem cell transplantation for systemic lupus erythematosus:the observation of long-term outcomes in a Chinese centre". C. Cao et al. Clin Exp Rheumatol. 2018 Jul-Aug;36(4):688 Authors: Cao C, Wang M, Sun J, Peng X, Liu Q, Huang L, Chai Y, Lai K, Chen P, Liu Q, Li Q, Peng Y, Xiong H, Zhang J, Chen M, Zeng K PMID: 30058528 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 1, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Evaluating IBD-specific antiglycan antibodies in serum of patients with spondyloarthritis and rheumatoid arthritis: are they really specific?
CONCLUSIONS: Our data fail to show an increased prevalence of anti-glycan antibodies in AS or PsA patients. ACCA were found to be significantly higher in RA patients than in controls, and may serve as an inflammatory biomarker. The present results do not support a role for antiglycan antibodies as biomarkers for spondyloarthritis. PMID: 29998822 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The prevalence and relevance of traditional cardiovascular risk factors in primary Sj ögren's syndrome.
The prevalence and relevance of traditional cardiovascular risk factors in primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 May 30; Authors: Bartoloni E, Alunno A, Valentini V, Valentini E, La Paglia GMC, Leone MC, Cafaro G, Marcucci E, Bonifacio AF, Luccioli F, Gerli R Abstract Accelerated atherosclerosis is a distinct feature of some inflammatory and autoimmune disorders and several specific autoimmune mechanisms and persistent inflammation have been identified to exert a pivotal role in precocious atherosclerotic damage in these disorders. Although increased atherosclerotic risk has been we...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevention of the progressive biochemical cartilage destruction under methotrexate therapy in early rheumatoid arthritis.
CONCLUSIONS: Under MTX therapy, biochemical cartilage integrity remains stable; no further cartilage destruction occurred if patients were treated early in the course of the disease. In addition, six months of MTX therapy triggered an alignment of dGEMRIC index of MCP joints with initially severe synovitis and less severe synovitis in an intra-individual assessment. This underlines the importance of an early treatment in eRA to reduce further cartilage damage of the inflamed joints. PMID: 29998824 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rapid immunoprofiling of cytokines, chemokines and growth factors in patients with active rheumatoid arthritis using Luminex Multiple Analyte Profiling technology for precision medicine.
Authors: Bahlas S, Damiati L, Dandachi N, Sait H, Alsefri M, Pushparaj PN Abstract OBJECTIVES: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease of unknown etiology, characterised by symmetric erosive synovitis, leading inevitably to the destruction of cartilage and bone as well as bursa and tendon sheaths of joints. Our aim of this study was to decipher the differential expression of cytokines, chemokines and growth factors in the plasma of RA patients with active disease, using magnetic bead-based Luminex Multiple Analyte Profiling (xMAP) technology, for precision medicine. METHODS: We ob...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Limited efficacy of targeted treatments in Sj ögren's syndrome: why?
Limited efficacy of targeted treatments in Sjögren's syndrome: why? Clin Exp Rheumatol. 2018 Jun 21; Authors: Tzioufas AG, Goules AV PMID: 29998826 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Survival and safety of infliximab bio-original and infliximab biosimilar (CT-P13) in usual rheumatology care.
CONCLUSIONS: IB was well-tolerated and comparable to IO, with no additional safety signals identified. The results suggest superior survival of IB over IO over the first 2 years. PMID: 29998827 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Successful treatment with tofacitinib for renal disorder due to amyloid A amyloidosis and immunoglobulin A nephropathy in a patient with rheumatoid arthritis.
Authors: Watanabe T, Hattori T, Ogawa Y, Jodo S PMID: 29998828 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and safety of mycophenolate mofetil and tacrolimus combination therapy in patients with lupus nephritis: a nationwide multicentre study.
CONCLUSIONS: Our findings suggest that a combined MMF and TAC treatment, with a favourable adverse-event profile, may be a beneficial option for LN patients with inadequate response to either MMF or TAC treatments. PMID: 29998829 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Redundant modulatory effects of proinflammatory cytokines in human osteoblastic cells in vitro.
CONCLUSIONS: Overall, these results suggest that IL-17, TRAIL and TNF-α sustain bone tissue inflammation associated with decrease of calcified component. To do so, they act redundantly each other, to amplify the inflammatory response in the bone. In conclusion, unravelling novel molecular targets within the bone-cytokine network represents a platform for innovative treatment of bone diseases due to immunological diseases such as psoriatic arthritis. PMID: 29998830 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comparison between the efficacy of combination therapy and monotherapy in connective tissue disease associated pulmonary arterial hypertension: a systematic review and meta-analysis.
CONCLUSIONS: Combination therapy targeting PAH may confer preferable therapeutic efficacy compared with monotherapy in patients with CTD-PAH as evidenced by a more remarkable reduction in the risk of clinical worsening and a probable improvement of exercise capacity in these patients. PMID: 29998831 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Does early seronegative arthritis develop into rheumatoid arthritis? A 10-year observational study.
CONCLUSIONS: Over a 10-year follow-up period, reclassification revealed significant heterogeneity in the diagnosis of seronegative RA. Therefore, seronegative arthritis should not be studied as a homogenous entity. PMID: 29998832 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients.
CONCLUSIONS: Our results suggest that exposure to specific pathogenic periodontal bacteria influences disease activity in SLE patients. These findings provide a rationale for assessing and improving periodontal health in SLE patients, as an adjunct to lupus therapies. PMID: 29998833 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical characteristics and mortality rate of the Thai elderly onset systemic sclerosis.
CONCLUSIONS: Myopathy and limitation of physical activity were frequently found among elderly onset SSc over against pulmonary involvement than in adult onset SSc. Mortality of elderly onset SSc was 5.7 times higher, and median survival was 11 years shorter, than adult onset SSc. PMID: 29998834 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The majority of patients with psoriatic arthritis are not eligible for randomised clinical trials.
CONCLUSIONS: Our results demonstrate that two thirds of patients with PsA in Iceland who are treated with TNFi would not have qualified for the randomised clinical trials performed leading up to the registration of the medications. Further studies with regards to whether outcomes are different between those who met the inclusion criteria and those who did not remain to be performed. PMID: 29998835 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Quantification of skin stiffness in patients with systemic sclerosis using real-time shear wave elastography: a preliminary study.
Authors: Yang Y, Yan F, Wang L, Xiang X, Tang Y, Li Q, Xiaoyan L Abstract OBJECTIVES: To assess the diagnostic value of shear wave elastography (SWE) quantification in patients with systemic sclerosis (SSc) and healthy controls. METHODS: Skin elastic modulus (E) values and thicknesses were measured at 6 skin sites between the SSc (n=37) and control (n=37) groups. Thickness and E values were converted into T- and E-scores, to allow skin thickness and stiffness of different regions to be quantified based on a single standard. T- and E-scores were compared with the modified Rodnan skin score (mRSS). RESULTS: E...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reduction of peripheral natural killer cells in patients with SAPHO syndrome.
Authors: Xu D, Liu X, Lu C, Luo J, Wang C, Gao C, Xie J, Li X Abstract OBJECTIVES: Little is known about the roles of peripheral immune cell subsets in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. Up to now, just a few studies have focused on this issue. We aimed to analyse the distribution and phenotype of T cell subsets and natural killer (NK) cells in the peripheral blood of patients with SAPHO syndrome. METHODS: The proportion and absolute counts of circulating immune cells were assessed in 19 patients diagnosed as SAPHO syndrome and 19 healthy controls. CD4+T cell subsets were a...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Down-regulation of serum miR-151a-3p is associated with renal tissue activity in class IV lupus nephritis.
Authors: Xiao H, Wei N, Su M, Xiong Z Abstract OBJECTIVES: The aim of this study was to explore the value of serum miRNA for evaluating renal tissue activity in patients with class IV lupus nephritis (LN). METHODS: First, we used a microRNA array to identify miRNAs differentially expressed between class IV LN patients and healthy volunteers (n=4/group). Then, we analysed the association between these identified miRNAs and renal tissue activity in class IV LN patients. Finally, to validate the results, 20 class IV LN patients (confirmed by renal biopsy) and 20 healthy control volunteers were further studied. ...
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Paediatric Beh çet's disease in Iran: report of 204 cases.
CONCLUSIONS: The clinical spectrum of PED-BD in Iran in this study was similar to that of other reports; however, genital ulcers, skin lesions (notably erythema nodosum), and gastrointestinal involvement were noticed to occur less frequently, while ocular lesions were more frequent and more severe compared to other reports. PMID: 29998839 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

What is metacarpophalangeal joint swelling in psoriatic arthritis? Ultrasound findings and reliability assessment.
CONCLUSIONS: Our study identifies that both IAS and PTI cause MCPj swelling, where PTI is almost as frequent as IAS as a cause of swelling. The reliability of PTI is at least as good as for IAS. PMID: 29998840 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Short-term costs associated with non-medical switching in autoimmune conditions.
CONCLUSIONS: Originator-to-biosimilar NMS in stable patients with autoimmune conditions could result in considerable switching costs for both providers and payers. PMID: 29998841 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasound detection of subclinical synovitis in rheumatoid arthritis patients in clinical remission: a new reduced-joint assessment in 3 target joints.
CONCLUSIONS: The US scan of 3 target joints showed a high sensitivity in detecting subclinical active synovitis in RA patients in clinical remission and can be feasible in the routine assessment of these patients. PMID: 29998842 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Duration of anti-TNF treatment in vascular Beh çet's disease: better to prolong treatment?
Duration of anti-TNF treatment in vascular Behçet's disease: better to prolong treatment? Clin Exp Rheumatol. 2018 May 31; Authors: Atas N, Babaoglu H, Varan O, Tufan A PMID: 29998843 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 14, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research