Does psoriatic axial spondyloarthritis phenotype correlate with imaging morphotype?
CONCLUSIONS: These data suggest that differences between axSpA and p-axSpA extend beyond presence of psoriasis, and include age, SI symmetry, and HLAB27 status. These findings may help explain the morphotype-phenotype relationship across axSpA, similar to those described in older radiographic studies. PMID: 31577217 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 4, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

A novel treatment in the management of genital ulceration in Beh çet's disease.
A novel treatment in the management of genital ulceration in Behçet's disease. Clin Exp Rheumatol. 2019 Oct 02; Authors: Benson RM, Kirwan J, Moots RJ PMID: 31577218 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 4, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Response to Ramon et al.
Authors: Diekhoff T PMID: 31573468 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Antifibrotic efficacy of nintedanib in a cellular model of systemic sclerosis-associated interstitial lung disease.
CONCLUSIONS: Our data demonstrate significant antifibrotic efficacy of nintedanib in SSc-ILD LF suggesting that nintedanib has the potential not only to prevent but also to reverse the increased activity of LF consequently attenuating excessive lung fibrosis observed in SSc-ILD. PMID: 31573469 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Is the T-G-CT-G SNRNP70 haplotype another proof that mixed connective tissue disease is distinct from systemic lupus erythematosus and systemic sclerosis? A novel gene variant in SNRNP70 gene.
CONCLUSIONS: Our results demonstrated that the T-G-CT-G SNRNP70 haplotype is another proof that MCTD may be distinct from SLE and SSc. The novel c.476-252G>A mutation in SNRNP70 gene created a new acceptor splice site and may potentially alert of splicing of the SNRNP70 transcript. PMID: 31573470 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Quality improvement for rheumatoid arthritis care: results from a focus group.
CONCLUSIONS: Themes uncovered in focus group discussions related predominantly to the clinical environment and patient-provider communication. These preliminary results identified the need to incorporate operational aspects of health care delivery into our assessment of the RA patient experience and formed the basis of a RA quality improvement programme targeting medication optimisation. PMID: 31573471 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Is cholecalciferol a potential disease modifying anti-rheumatic drug for the management of rheumatoid arthritis?
Authors: Bellan M, Andreoli L, Nerviani A, Piantoni S, Avanzi GC, Soddu D, Hayden E, Pirisi M, Sainaghi PP Abstract Vitamin D is a pleiotropic molecule with a well-characterised immunomodulatory activity in vitro; however, its potential clinical application in autoimmune conditions has yet to be clarified. Several authors have investigated the use of vitamin D as a disease-modifying anti-rheumatic drug (DMARD) in rheumatoid arthritis (RA), obtaining divergent conclusions. This systematic review summarises and critically analyses the findings of papers assessing the impact of vitamin D supplementation on pain relief...
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Response to 'Diagnostic accuracy of dual energy computed tomography and joint aspiration: a prospective study in patients with suspected gouty arthritis' Notzel et al.
Authors: Ramon A, Schmitt M, Ne R, Maillefert JF, Ornetti P PMID: 31573473 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Does angiotensin and endothelin receptor blockade have an impact on lung function? An analysis from the EUSTAR database.
Authors: Radic M, Becker MO, Distler O, Huscher D, Siegert E, Riemekasten G, EUSTAR group PMID: 31573474 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical features and current treatments of adult-onset Still's disease: a multicentre survey of 517 patients in China.
This study tried to assess the clinical characteristics, laboratory tests, and treatments of Chinese AOSD patients, and make a retrospective analysis. METHODS: We collected from 7 hospitals in China a total of 517 Chinese patients with AOSD who satisfied the Yamaguchi criteria. We retrospectively evaluated their clinical features, laboratory tests, treatments and compared them with published data from different studies. All the data in this study were from medical records and further statistic analyses. RESULTS: We evaluated a total of 517 AOSD patients, 72% female, average age of onset was 37.7; spiking fever, ras...
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

How normal is the enthesis by ultrasound in healthy subjects?
CONCLUSIONS: Our results show a relatively high prevalence of US findings of "active" inflammation at the lower limb entheses in a group of healthy subjects, thus questioning the discriminant power of the OMERACT definitions for the diagnosis of "active" enthesitis. A combination of grey-scale and PD findings at a specific threshold to be defined could improve both the reliability and clinical usefulness of US. PMID: 31573476 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

"There is something you must see": breaking down the remission concept in rheumatoid arthritis from a rheumatologist's perspective.
CONCLUSIONS: Currently, rheumatologists would not accept a domain as more important than others in remission. Our suggestion is, not to generate a universal definition of remission - one that could cover all aspects - but rather to develop definitions of remission for the different settings that could be pondered by the patient's perspective. PMID: 31573477 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Atypical phenotype without fever in a Japanese family with an autosomal dominant transmission of familial Mediterranean fever due to heterozygous MEFV Thr577Asn mutations.
Authors: Endo Y, Koga T, Nakashima M, Mishima H, Yoshiura KI, Kawakami A PMID: 31573478 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Non-invasive digital thermal monitoring and flow-mediated dilation in systemic sclerosis.
In this study, we investigated the cross-sectional correlation of FMD and DTM variables to inform an optimised noninvasive study of SSc endothelial function. A student's T-test was used to compare means of DTM across binary variables. METHODS: Consented SSc registry patients were included in this analysis. The subjects were prepared for FMD and DTM per standardised guidelines. The SSc clinical features were recorded. Spearman's Rank Correlation was used to assess the strength of a relationship FMD and DTM variables. RESULTS: Thirty-four SSc subjects had FMD and DTM performed on the same day. Relative (0.42, p=
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hypogammaglobulinaemia in identical twin sisters with rheumatoid arthritis.
Authors: Krasselt M, Baerwald C, Seifert O PMID: 31573480 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Imbalance between angiogenic and anti-angiogenic factors in sera from patients with large-vessel vasculitis.
CONCLUSIONS: Our overall results demonstrate a circulating molecular profile characterised by a prevailing expression of anti-angiogenic soluble factors. PMID: 31573481 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - October 3, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Erratum - Salonen PH, S äilä H, Salonen JH, Linna M, Helminen M, Kauppi MJ: Pneumonia in children with juvenile idiopathic arthritis in Finland 1999-2014: a nationwide retrospective register linkage study". Clin Exp Rheumatol 2018; 36: 502-7.
Erratum - Salonen PH, Säilä H, Salonen JH, Linna M, Helminen M, Kauppi MJ: Pneumonia in children with juvenile idiopathic arthritis in Finland 1999-2014: a nationwide retrospective register linkage study". Clin Exp Rheumatol 2018; 36: 502-7. Clin Exp Rheumatol. 2019 Sep-Oct;37(5):888 Authors: Salonen PH, Säilä H, Salonen JH, Linna M, Helminen M, Kauppi MJ PMID: 31530347 [PubMed] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 20, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Role of IL-33/ST2 signaling pathway in systemic sclerosis and other fibrotic diseases.
Authors: Xu D, Barbour M, Jiang HR, Mu R Abstract Systemic sclerosis (SSc) is a complex autoimmune disease characterised by fibrosis of the skin and multiple internal organs. Interleukin 33 (IL-33) has recently been investigated as a potential key player in the pathogenesis of SSc and other fibrotic diseases, owing to its effects on tissue fibrosis. Understanding how IL-33 is regulated and how it contributes to the development of fibrosis will be important to elucidate disease pathogenesis and may shed light on new areas for therapeutic development for patients. Here we discuss the recent research progress in our u...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Geoepidemiological big data approach to sarcoidosis: geographical and ethnic determinants.
Authors: Brito-Zerón P, Kostov B, Superville D, Baughman RP, Ramos-Casals M, Autoimmune Big Data Study Group Abstract In sarcoidosis, a rare multiorgan disease of unknown aetiology characterised by non-caseating epitheloid cell granulomas, three geoepidemiological factors are major aetiopathogenic factors: geolocation, ethnicity, and personal environment. Geographically, sarcoidosis is mainly reported in the Northern Hemisphere, with the highest incidence rates uniformly reported in countries located at the highest latitudes. The main geoepidemiological-driven differences across the world are of greater fema...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

QT and QT dispersion intervals in long-standing and moderately active rheumatoid arthritis: results from a multicentre cross-sectional study.
Authors: Erre GL, Piras A, Piga M, Fedele AL, Mangoni AA, Lazzerini PE, Gremese E, Mathieu A, Ferraccioli G, Passiu G, Saba PS, EDRA study group. Abstract OBJECTIVES: To define the prevalence of prolonged QT interval and QT dispersion (QTd) in rheumatoid arthritis (RA) patients and in a control population. METHODS: QT interval corrected by Bazett's formula (QTc) was calculated from standard 12-lead ECGs in 963 subjects free of previous cardiovascular events (646 RA patients and 317 controls strictly matched for age, sex and cardiovascular risk factors). RESULTS: RA patients (59.6±9.6 years, 68.1% fem...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Effects of birth months on rheumatic diseases in South Korea: a nationwide case-control study.
CONCLUSIONS: Seasonal variations in infectious agents, sun exposure, and food ingestion during gestation or early infancy seem to explain the association between birth month/season and development of rheumatic diseases. PMID: 31498065 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Spondyloarthritis: not only enthesitis.
Authors: Azzolin I, Massazza G, Iagnocco A Abstract Spondyloarthritis represents a heterogeneous group of inflammatory diseases that share common genetic, clinical and radiological features. Those diseases are characterised by inflammation in the spine and in the peripheral joints. Enthesitis is considered a pathological hallmark of the spondyloarthritis group of conditions but there are also many other relevant clinical manifestations. The aim of this article is to present an overview on articular and extra-articular manifestations and comorbidities associated with spondyloarthritis. PMID: 31498066 [PubMed - a...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Evolution of one systemic rheumatic disease into another: scleroderma evolving to eosinophilic fasciitis with myositis.
Authors: Zampeli E, Pantelidaki A, Moutsopoulos HM PMID: 31498067 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased serum levels of microfibrillar-associated protein 4 (MFAP4) are not associated with clinical synovitis in rheumatoid arthritis but may reflect underlying cardiovascular comorbidity.
Authors: Issa SF, Lindegaard HM, Lorenzen T, Junker K, Christensen AF, Hørslev-Petersen K, Holmskov U, Sorensen GL, Junker P Abstract OBJECTIVES: To study circulating MFAP4 in rheumatoid arthritis (RA) and its associations with clinical phenotype. METHODS: Early RA (ERA): 47 patients with newly diagnosed, treatment naïve RA were included. Serum MFAP4, clinical and laboratory disease variables were recorded serially during 12 months of intensive synovitis suppressive treatment. Long-standing RA (LRA): 317 patients participated, all receiving DMARD treatment. Disease activity, autoantibody status, ext...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The effect of certolizumab drug concentration and anti-drug antibodies on TNF neutralisation.
CONCLUSIONS: Anti-certolizumab antibodies were detected in a large proportion of patients, but in most cases where ADAs were detected, certolizumab was also present in high concentrations, directly correlating with in vitro neutralising capacity. These results indicate that measurement of certolizumab drug levels, rather than ADAs, have direct clinical significance. PMID: 31498069 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

IL-34 modulates rheumatoid synovial fibroblasts proliferation and migration via ERK/AKT signalling pathway.
CONCLUSIONS: Our data add novel insights into the pathogenesis of RA and we suggest that IL-34 plays a dominant role in controlling migration and proliferation of sFLS. Consequently, therapeutic strategies targeting IL-34 could be a potent therapy for RA. PMID: 31498070 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Early development of new cardiovascular risk factors in the systemic vasculitides.
Authors: Monti S, Robson J, Klersy C, Kraven A, Montecucco C, Watts R, Merkel PA, Luqmani R Abstract OBJECTIVES: To analyse the frequency and predictors of new-onset cardiovascular (CV) risk factors in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and giant cell arteritis (GCA). METHODS: We analysed the frequency and predictors of new-onset hypertension and/or diabetes mellitus (HTN/DM) amongst patients with AAV or GCA recruited in the Diagnostic and Classification of Vasculitis (DCVAS) study. Patients with pre-existing HTN/DM were excluded. RESULTS: We included 873 pat...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Variation in the synovial fluid metabolome according to disease activity of rheumatoid arthritis.
CONCLUSIONS: We found the SF metabolic alterations in RA patients according to disease activity by using GC/TOF MS and identified 12 candidate metabolic biomarkers that may well reflect the disease activity of RA. SF metabolomic approaches based on GC/TOF MS might provide additional information relating to monitoring disease activity in RA. PMID: 31498072 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reliability, construct validity and responsiveness to change of the PROMIS-29 in systemic sclerosis-associated interstitial lung disease.
CONCLUSIONS: PROMIS-29 has adequate reliability and construct validity for evaluation in SSc-ILD. It has moderate-to-large correlations with other PROs. The PROMIS-29 domains were not found to change over time in this cohort, likely due to stable nature of the observational cohort. PMID: 31498073 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Predictors of drug retention and treatment response in axial spondyloarthritis patients treated with certolizumab: real-life results from the HURBIO registry.
Authors: Bilgin E, Farisoğulları B, Armağan B, Sarı A, Yardımcı GK, Bölek EÇ, Kılıç L, Akdoğan A, Bilgen ŞA, Karadağ Ö, Ertenli Aİ, Kiraz S, Kalyoncu U Abstract OBJECTIVES: To assess the real-life retention rate of certolizumab and factors related to retention of certolizumab. METHODS: We analysed all patients who received at least 1 dose of certolizumab and were registered in the HURBIO database. Patients with at least 1 control visit were included in efficacy analysis. Drug retention rates were calculated using the Kaplan-Meier method and predictors of drug retention was de...
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reply to J. Gao's commentary on: Aromatic hydrocarbon receptor provides a link between smoking and rheumatoid arthritis in peripheral blood mononuclear cells.
Authors: Cheng L, Qian L PMID: 31498075 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Late-onset protracted febrile myalgia syndrome successfully treated with colchicine owing to heterozygous MEFV exon 2 variants.
Authors: Endo Y, Koga T, Furukawa K, Sumiyoshi R, Ichinose K, Kawakami A PMID: 31498076 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Italian recommendations for influenza and pneumococcal vaccination in adult patients with autoimmune rheumatic diseases.
CONCLUSIONS: Influenza and pneumococcus vaccinations are effective and safe in patients with ARDs. More efforts should be made to translate the accumulated evidence into practice. PMID: 31498077 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Aromatic hydrocarbon receptor provides a link between smoking and rheumatoid arthritis in peripheral blood mononuclear cells: a commentary.
Authors: Zhou L, Wang J, Gao J PMID: 31498078 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - September 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sj ögren's syndrome towards precision medicine: the challenge of harmonisation and integration of cohorts.
Sjögren's syndrome towards precision medicine: the challenge of harmonisation and integration of cohorts. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):175-184 Authors: Goules AV, Exarchos TP, Pezoulas VC, Kourou KD, Venetsanopoulou AI, De Vita S, Fotiadis DI, Tzioufas AG Abstract Primary Sjögren's syndrome (pSS) is a chronic, systemic autoimmune disease with diverse clinical picture and outcome. The disease affects primarily middle-aged females and involves the exocrine glands leading to dry mouth and eyes. When the disease extends beyond the exocrine glands (systemic form), certain extra...
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Systemic manifestations of primary Sj ögren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients.
Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):97-106 Authors: Retamozo S, Acar-Denizli N, Rasmussen A, Horváth IF, Baldini C, Priori R, Sandhya P, Hernandez-Molina G, Armagan B, Praprotnik S, Kvarnstrom M, Gerli R, Sebastian A, Solans R, Rischmueller M, Pasoto SG, Valim V, Nordmark G, Kruize A, Nakamura H, Hofauer B, Giacomelli R, Fernandes Moça Trevisani V, Devauchelle-Pensec V, Atzeni F, Gheita TA, Consani-Fe...
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Autoimmune epithelitis beyond the exocrine glands: an unusual case of anti-Ro/La and Scl-70 lymphocytic interstitial pneumonia.
CONCLUSIONS: This case with LIP and disease-specific autoantibodies for pSS and SSc teaches the complexity and overlapping nature of both diseases, extending from autoimmune epithelitis with ectopic germinal centres to fibrosis-related SSc. It points out the significance of the affected tissue biopsy, which may uncover the different disease phenotypes. To this end, treatment with anti-CD20, acting at the crossroads of the pathogenetic mechanisms of both diseases may serve as a first choice therapy. PMID: 31464665 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Assessment of major salivary gland ultrasonography in Sj ögren's syndrome. A comparison between bedside and post-examination evaluations.
CONCLUSIONS: Our study indicates a trend favouring longitudinal video of the parotid gland as preferred projection, gland and storage format. PMID: 31464666 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sj ögren's syndrome is not a risk factor for periodontal disease: a systematic review.
CONCLUSIONS: No significant differences in the GI, PI, CAL, and PPD were observed in patients with SS compared to controls. These results indicate that there is no evidence of a higher risk for periodontal disease in patients with SS, while SS patients are more susceptible to caries compared to non-SS patients. PMID: 31464667 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Thymic stromal lymphopoietin expression from benign lymphoproliferation to malignant B-cell lymphoma in primary Sj ögren's syndrome.
CONCLUSIONS: TSLP progressively increases from benign to malignant B-cell lymphoproliferation in pSS. The salivary epithelium expresses TSLP but, with the progression of lymphoproliferation, the B-cells may represent the major source of TSLP, in its long inducible isoform. A possible pathogenetic role of TSLP is herein hypothesised in pSS for the first time. Further analyses on TSLP, also as a biomarker of pSS and related lymphoproliferation, are worthwhile. PMID: 31464668 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The Big Data Sj ögren Consortium: a project for a new data science era.
The Big Data Sjögren Consortium: a project for a new data science era. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):19-23 Authors: Acar-Denizli N, Kostov B, Ramos-Casals M, Sjögren Big Data Consortium PMID: 31464669 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sicca/Sj ögren's syndrome triggered by PD-1/PD-L1 checkpoint inhibitors. Data from the International ImmunoCancer Registry (ICIR).
CONCLUSIONS: Patients with Sjögren's syndrome triggered by ICI display a very specific profile different from that reported in idiopathic primary SS, including more frequent occurrence in men, a higher mean age, a predominant immunonegative serological profile, and a notable development of organ-specific autoimmune involvement in spite of the poor immunological profile. The close association found between sicca/Sjögren's syndrome and primarily PD-1 blockade requires further specific investigation. PMID: 31464670 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Current limitations and ongoing initiatives to evaluate the activity, damage and outcome of primary Sj ögren's syndrome.
Current limitations and ongoing initiatives to evaluate the activity, damage and outcome of primary Sjögren's syndrome. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):24-26 Authors: De Vita S, Zabotti A, Gandolfo S PMID: 31464671 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The necessity of novel biomarkers in primary Sj ögren's syndrome.
The necessity of novel biomarkers in primary Sjögren's syndrome. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):16-18 Authors: Tzioufas AG, Goules AV PMID: 31464672 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Renal involvement in primary Sj ögren's syndrome: natural history and treatment outcome.
CONCLUSIONS: Interstitial nephritis follows a slow course and does not improve with systemic immunosuppression while GN has a favourable treatment response in those with MPGN pathology. PMID: 31464673 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Genetics in Sj ögren's syndrome: where we are and where we go.
Genetics in Sjögren's syndrome: where we are and where we go. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):234-239 Authors: Harris VM, Scofield RH, Sivils KL Abstract Sjögren's syndrome is a complex autoimmune disease that involves dysregulation of immune responses that preferentially target exocrine glands. Systemic manifestations vary and may involve nearly every organ system. Genetic studies to date are in their infancy relative to other autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, each with more than 100 genetic associations now established. Howev...
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2019: Sj ögren's syndrome.
One year in review 2019: Sjögren's syndrome. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):3-15 Authors: Cafaro G, Croia C, Argyropoulou OD, Leone MC, Orlandi M, Finamore F, Cecchettini A, Ferro F, Baldini C, Bartoloni E Abstract Primary Sjögren's syndrome (pSS) is a complex and heterogeneous disorder characterised by a wide spectrum of glandular and extra-glandular features. Novel insights into disease pathogenesis and the discovery of novel biomarkers are allowing us to characterise the disease not only phenotypically on the basis of clinical presentation, but also on the basis of the en...
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The kaleidoscope of neurological manifestations in primary Sj ögren's syndrome.
The kaleidoscope of neurological manifestations in primary Sjögren's syndrome. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):192-198 Authors: Alunno A, Carubbi F, Bartoloni E, Cipriani P, Giacomelli R, Gerli R Abstract Neurologic involvement is a common extraglandular manifestation of primary Sjögren's syndrome (pSS), is varied and can be divided anatomically into 3 categories: central nervous system, peripheral neuropathies and autonomous nervous system manifestations. According to different study cohorts, neurological manifestations can occur in 18-45% of pSS patients, with the periphera...
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Double anti-B cell and anti-BAFF targeting for the treatment of primary Sj ögren's syndrome.
Double anti-B cell and anti-BAFF targeting for the treatment of primary Sjögren's syndrome. Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):199-208 Authors: Gandolfo S, De Vita S Abstract Primary Sjögren's syndrome (pSS) is an autoimmune connective tissue disease characterised by an enhanced lymphoproliferative status, with a greater risk of hesitating in malignant lymphoma. The pathological hallmark of pSS is the mucosa-associated lymphoid tissue (MALT) arising in chronically inflamed tissues, mainly in salivary glands (SG), where inflammation, autoimmunity and lymphoproliferation coexist. ...
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Application of artificial neural network analysis in the evaluation of cardiovascular risk in primary Sj ögren's syndrome: a novel pathogenetic scenario?
CONCLUSIONS: This study represents the first application of ANNs to the analysis of factors contributing to CV events in pSS. When compared to AHC, ANNs had the advantage of better stratifying CV risk in pSS, opening new avenues for planning specific interventions to prevent long-term CV complications in pSS patients. PMID: 31464678 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - August 31, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research