Trends in employment and hospitalisation in patients with Sj ögren's syndrome 1996-2016: results from the German National database.
Trends in employment and hospitalisation in patients with Sjögren's syndrome 1996-2016: results from the German National database. Clin Exp Rheumatol. 2019 Jul 03; Authors: Callhoff J, Thiele K, Dörner T, Zink A, Richter JG, Henes J, Albrecht K Abstract OBJECTIVES: To assess trends in treatments and outcomes in patients with primary Sjögren's syndrome (pSS), focusing on employment, hospitalisation and medical treatment in the past two decades. METHODS: From 1996 to 2016, approximately 300 patients with pSS were annually documented in the National Database of the German Collaborative ...
Source: Clinical and Experimental Rheumatology - July 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

MiR-451 suppresses inflammatory responses in ankylosing spondylitis by targeting macrophage migration inhibitory factor.
CONCLUSIONS: The MIF level was elevated in AS patients with greater radiographic damage and overexpression of miR-451 suppressed the MIF and inflammatory cytokine levels. These findings suggest miR-451/MIF may be a novel therapeutic target in the treatment of AS. PMID: 31287414 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - July 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Management of maternal antiphospholipid syndrome.
Authors: Fernandes MA, Gerardi MC, Andreoli L, Tincani A Abstract Antiphospholipid syndrome (APS) is a systemic autoimmune disease which manifests as thrombotic and/or obstetric adverse events, mediated by persistent circulating antiphospholipid antibodies (aPL) detected by means of three tests: lupus anticoagulant, anticardiolipin and anti β2-glycoprotein I antibodies. It can be isolated or associated with other autoimmune rheumatic diseases. During pregnancy, patients with APS have a higher risk of obstetric complications and a higher thrombotic risk due to the pregnancy itself. Therefore, a preconception co...
Source: Clinical and Experimental Rheumatology - July 11, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Microbiota stratification identifies disease-specific alterations in neuro-Beh çet's disease and multiple sclerosis.
CONCLUSIONS: Patient cohort stratification may be needed to facilitate identification of common microbiota community shifts for causation testing in disease. PMID: 31172918 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

MicroRNA differential expression shared between rheumatoid arthritis and acute myocardial infarction: an exploratory study.
Authors: Paredes S, Taverner D, Ferré R, Alegret JM, Masana L, Vallvé JC PMID: 31172919 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Use of synthetic and biological DMARDs in patients with enteropathic spondyloarthritis: a combined gastro-rheumatological approach.
Authors: Chimenti MS, Conigliaro P, Triggianese P, Canofari C, Cedola F, Onali S, Calabrese E, Romeo S, Neri B, De Cristofaro E, Biancone L, Perricone R Abstract OBJECTIVES: The aim of this 2-year prospective study was to assess the diagnostic and therapeutic effect of a combined gastro-rheumatological approach in enteropathic spondyloarthritis (eSpA) patients. METHODS: Inflammatory bowel disease (IBD) patients with joint pain were referred by IBD-dedicated gastroenterologists to a dedicated rheumatologist. At baseline and at 3, 6, 12, 24 months, the following parameters were recorded: clinical and biochemical ...
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Humanin prevents undesired apoptosis of chondrocytes without interfering with the anti-inflammatory effect of dexamethasone in collagen-induced arthritis.
CONCLUSIONS: Our results suggest that the combination of HNG and GCs may provide a new treatment strategy in conditions of chronic inflammation, which could potentially prevent bone growth impairment. PMID: 31172921 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comparing the clinical profile of adults and children with Beh çet's syndrome in the UK.
This study compares the clinical features of adult and juvenile onset Behçet's Syndrome (JBS) in a UK population. METHODS: Two clinical databases of BS patients were compared. The JBS database was collected at the Great Ormond Street Hospital for Children, London (n=46). The adult database was collected at the Hammersmith Hospital, London (n=560). RESULTS: Oro-genital aphthosis had high prevalence in both the JBS and the adult cohort (oral: 97.8% vs. 96.6%, genital: 73.9% vs. 75.7%). The JBS cohort was more likely to have gastrointestinal involvement (21.7% vs. 4.5%, p
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Review of major endocrine abnormalities in patients with systemic lupus erythematosus.
CONCLUSIONS: We report concomitant endocrine disease in 7.76 % of our 708 SLE cohort followed, for almost 40 years, at UCLH. These patients have increased liability to develop a second endocrine disease, but overall there is no difference in terms of mortality between SLE patients with or without an endocrinopathy. It is important to capture endocrine diseases in SLE as the symptoms they cause may mimic SLE features, but require quite distinct treatment. PMID: 31172923 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Differential serum levels of interleukin-37 in patients with tumour necrosis factor receptor-associated periodic syndrome (TRAPS).
Authors: Lucherini OM, Vitale A, Obici L, Sota J, Frediani B, Merlini G, Rigante D, Cantarini L PMID: 31172924 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The effect of gender on methotrexate prescription attitudes in Italian rheumatoid arthritis patients: the MARI study.
CONCLUSIONS: In Italy, prescription patterns of MTX do not differ between genders. However, women seem to be at higher risk of adverse events leading to MTX modifications. PMID: 31172925 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Correlation between capillaroscopic classifications and severity in systemic sclerosis: results from SCLEROCAP study at inclusion.
CONCLUSIONS: The correlations found between capillaroscopy and severity of SSc are promising before the ongoing prospective study definitively assesses whether capillaroscopy staging predicts complications of SSc. Only two capillaroscopic patterns seem useful: one involving many giant capillaries and haemorrhages and the other with severe capillary loss. PMID: 31172926 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased intra-articular granzyme M may trigger local IFN- λ1/IL-29 response in rheumatoid arthritis.
CONCLUSIONS: These data indicate that GrM levels are increased in RA synovial fluid and that GrM can stimulate proinflammatory IL-29 release from fibroblasts, suggesting a role of GrM in the pathogenesis of RA. PMID: 31172927 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Mechanics of early biventricular impairment in systemic sclerosis and the effects of peripheral arterial haemodynamics.
CONCLUSIONS: Speckle-tracking echocardiography demonstrates the mechanics of RV early impairment in SSc that develops and progresses independently from the concomitant LV impairment, which, in turn, may be influenced by peripheral microvascular abnormalities in the absence of macrovascular damage. PMID: 31172928 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 9, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ocular ischaemic complications in giant cell arteritis: CHADS2-score predicts risk of permanent visual impairment.
CONCLUSIONS: The risk of PVL secondary to GCA increases with age but is lower in patients presenting with constitutional symptoms and/or exhibiting axillary artery involvement. The CHADS2-score may help to discriminate patients with low vs. high risk of PVL. PMID: 31162028 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The different clinical patterns of giant cell arteritis.
Authors: de Boysson H, Liozon E, Ly KH, Dumont A, Delmas C, Aouba A Abstract OBJECTIVES: To estimate the frequency of different clinical patterns in giant-cell arteritis (GCA) at onset. METHODS: All GCA patients consecutively followed-up in two referral centers for GCA with a biopsy-proven diagnosis and/or large-vessel vasculitis (LVV) demonstrated on imaging were analysed. RESULTS: We analysed the initial clinical presentation of 693 patients with a median age of 75 [48-94] years and including 486 (70%) women. We identified four different clinical patterns: isolated cranial GCA (in 80%), symptomatic LVV wi...
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Acetylcholinesterase-associated inflammation in patients with giant cell arteritis. Evaluation by histology and 11C-donepezil PET/CT.
CONCLUSIONS: AChE is highly expressed in the inflamed vessel wall of patients with GCA. Although, 11C-donepezil PET/CT showed no vascular uptake in the FDG PET/CT verified LV-GCA patients, histological findings raise the possibility that AChE can be used in the development of new diagnostic and disease monitoring tools for GCA. PMID: 31162030 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cost-effectiveness of rituximab versus azathioprine for maintenance treatment in antineutrophil cytoplasmic antibody-associated vasculitis.
CONCLUSIONS: Maintenance treatment by rituximab could be cost-effective for preventing relapses in patients with AAV. PMID: 31162031 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cytokine expression in temporal arteries: comparative analysis between patients with biopsy-positive giant cell arteritis, biopsy-negative giant cell arteritis and biopsy-negative without arteritis.
Authors: Grossman C, Yassin N, Avivi C, Bornstein G, Ben-Zvi I, Barshack I Abstract OBJECTIVES: To investigate whether expression of pro-inflammatory cytokines in the temporal artery may aid in differentiating biopsy-negative giant cell arteritis (GCA) patients from those with a negative biopsy without arteritis. METHODS: We investigated cytokine expression in temporal artery biopsy (TAB) of 54 consecutive patients: 17 with biopsy-positive GCA, 17 with biopsy-negative GCA, and 20 biopsy-negative without arteritis. We compared the expression rate of the following cytokines among these 3 groups of patients: inter...
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Abdominal adipose tissue predicts major cardiovascular events in systemic necrotising vasculitides.
CONCLUSIONS: Abdominal visceral adipose tissue is a reliable surrogate marker of CV risk and predicts incident MCVEs in SNV patients. Abdominal adipose tissue should be probably evaluated routinely in these patients to assess CV risk. PMID: 31162033 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2019: vasculitis.
Authors: Monti S, Bond M, Felicetti M, Cavallaro E, Posarelli C, Elefante E, Ferro F, Talarico R, Quartuccio L, Baldini C Abstract Systemic vasculitis are disabling complex disorders potentially involving any organ and system. Tremendous efforts have been made recently in this field with novel insights into pathogenesis and new therapy in the pipeline. Following the previous annual reviews of this one year in review series, in this paper we provide a critical digest of the most recent literature regarding pathogenesis, clinical manifestations and therapy, with the ultimate aim of addressing whether the existing dat...
Source: Clinical and Experimental Rheumatology - June 6, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Clinical features of patients with systemic lupus erythematosus according to health-related quality of life, entity of pain, fatigue and depression: a cluster analysis.
CONCLUSIONS: Identification of clusters of patients according to HRQoL levels could be useful to improve SLE management, aiming at personalised medicine. PMID: 31140392 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Identifying a marked inflammation mediated cardiac dysfunction during the development of arthritis in collagen-induced arthritis mice.
CONCLUSIONS: Joint inflammation is associated with an obvious cardiac dysfunction and enhanced inflammation infiltration and inflammatory cytokine production in cardiomyocytes and cardiac fibroblasts during CIA development. Our data provide the direct evidence that inflammation contributes to the development of cardiac diseases in RA patients. PMID: 31140393 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2019: novelties in the treatment of rheumatoid arthritis.
Authors: Silvagni E, Di Battista M, Bonifacio AF, Zucchi D, Governato G, Scirè CA Abstract The current treatment approach in rheumatoid arthritis (RA) follows a stepwise management, starting from early introduction of conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs), moving to biological (b) DMARDs and targeted synthetic (ts) DMARDs. In the last few years, new drugs with different mechanisms of action have demonstrated their efficacy in treating such a disabling condition, and their approval, along with other more "experienced" treatments, has established their effectiven...
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Red cell distribution width correlates with fatigue levels in a diverse group of patients with systemic lupus erythematosus irrespective of anaemia status.
Authors: Wincup C, Parnell C, Cleanthous S, Tejera Segura B, Nguyen MH, Bryant K, O'Neill SG, Richards T, Rahman A Abstract OBJECTIVES: Fatigue remains a debilitating feature of systemic lupus erythematosus (SLE). Although in some cases this may be the result of intercurrent fibromyalgia, mood disorder or untreated metabolic syndrome, in many cases the cause is unclear. The aim of this study was to investigate the relationship between fatigue and red cell distribution width (RDW), a measure of variability in erythrocyte size and volume. METHODS: A total of 225 patients were recruited from three clinics in Engla...
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

CD74 is a T cell antigen in spondyloarthritis.
CONCLUSIONS: CD74 is a T cell antigen in SpA, eliciting Th1 and Th17 responses, which may be relevant in disease pathogenesis. Recognition of the highly immunogenic amino acid residues of CD74 may contribute to our understanding of autoimmune responses of T helper cells in SpA. PMID: 31140396 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Demographic and clinical differences between ankylosing spondylitis and non-radiographic axial spondyloarthritis: results from a multicentre retrospective study in the Lazio region of Italy.
Authors: Chimenti MS, Conigliaro P, Navarini L, Martina FM, Peluso G, Birra D, Sessa P, Anzidei M, Scolieri P, Bruzzese V, Santoboni G, Cardello P, Gremese E, Afeltra A, Valesini G, Sebastiani GD, Perricone R, Scrivo R Abstract OBJECTIVES: Axial spondyloarthritides (axSpA) are a group of disorders that share similar pathogenetic mechanisms and clinical picture. The aim of this retrospective multicentric study was to evaluate demographic and clinical differences between ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA) patients. METHODS: Patients from 7 rheumatological centres in the Lazio region...
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

An intense physical rehabilitation program determines pain relief and improves the global quality of life in patients with fibromyalgia.
CONCLUSIONS: According to our results, an intense physical rehabilitation program could be considered a promising essential step in the management of FM patients. PMID: 31140398 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reactive arthritis: current treatment challenges and future perspectives.
Authors: Lucchino B, Spinelli FR, Perricone C, Valesini G, Di Franco M Abstract Reactive arthritis is a group of inflammatory joint diseases triggered by a previous infection, often associated with extra-articular features. The clinical course and consequently the treatment are complicated by the variability of the disease evolution in the single patient. In some patients, the disease assumes a chronic and destructing course, requiring the introduction of therapy. However, the role of antibiotic treatment of the triggering infection as well as the role of the currently available disease-modifying anti-rheumatic dru...
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Features of repeated muscle biopsies and phenotypes of monocytes in paired blood samples and clinical long-term response to treatment in patients with idiopathic inflammatory myopathy: a pilot study.
Authors: Tang Q, Gheorghe KR, Zhang XM, Lindroos E, Alexanderson H, Wick C, Bruton M, Fernandes-Cerqueira C, Harris RA, Nennesmo I, Lundberg IE Abstract OBJECTIVES: In a pilot study we aimed to identify biomarkers in repeated muscle biopsies and paired blood samples, taken before and after conventional immunosuppressive therapy, in order to predict long-term therapeutic response in patients with idiopathic inflammatory myopathies (IIM). METHODS: Muscle biopsies were selected from 13 new onset patients, six responders and seven non-responders. Repeated muscle biopsies after a median of 11 months follow-up were a...
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prevalence of calcium pyrophosphate deposition disease in a cohort of patients diagnosed with seronegative rheumatoid arthritis.
CONCLUSIONS: CPPD disease can mimic seronegative RA at baseline and is important in the differential diagnosis of seronegative arthritis at baseline and during follow-up. The prevalence of CPPD patients in our early seronegative RA patients was 3.9%, the percentage was 7.0% among patients ≥60 years at baseline. PMID: 31140401 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 30, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pattern of muscle involvement in inclusion body myositis: a sonographic study.
Authors: Albayda J, Christopher-Stine L, Bingham Iii CO, Paik JJ, Tiniakou E, Billings S, Uy OM, Burlina P PMID: 31111821 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 23, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Lung consolidation and mediastinal lymphadenopathy in patients with early anti-citrullinated protein antibody-positive rheumatoid arthritis.
Authors: Endo Y, Koga T, Tsutsui S, Ashizawa K, Kawashiri SY, Kawakami A PMID: 31111822 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 23, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2019: pathogenesis of rheumatoid arthritis.
Authors: Croia C, Bursi R, Sutera D, Petrelli F, Alunno A, Puxeddu I Abstract Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease influenced by both genetic and environmental factors. Over the last few years, particular attention has been given to novel genes and to the close interaction between genetic factors and epigenetic mechanisms. Research has also focused on the influence of environmental factors on disease development, and on new mechanisms of the innate and adaptive immune system that can influence the different stages of RA. However, there are still several aspects of the disease that ...
Source: Clinical and Experimental Rheumatology - May 23, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between increased arterial stiffness measured by brachial-ankle pulse wave velocity and cardiovascular events in Takayasu's arteritis patients.
This study aims to investigate the association between arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) and cardiovascular events (CVEs) in patients with Takayasu's arteritis (TAK). METHODS: A total of 240 TAK patients, who underwent baPWV measurement, were included in the study. The primary outcome was CVEs, which was defined as presently or previously diagnosed with myocardial infarction, unstable angina, congestive heart failure, aortic aneurysm/dissection, cerebral infarction/transient ischaemic attack (TIA), or cerebral haemorrhage. RESULTS: A total of 74 (30.8%) patients with CVEs wer...
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of obesity on inflammation and damage in spondyloarthritis: a systematic literature review on body mass index and imaging.
CONCLUSIONS: BMI is linked to both axial and peripheral new bone formation and entheseal inflammation by imaging, as supported by the limited number of studies in the literature. Its effect on the sacroiliac joint and spinal inflammation is not clear as MRI studies are lacking. PMID: 31074718 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Sirolimus selectively increases circulating Treg cell numbers and restores the Th17/Treg balance in rheumatoid arthritis patients with low disease activity or in DAS28 remission who previously received conventional disease-modifying anti-rheumatic drugs.
CONCLUSIONS: Sirolimus can favourably expand Treg cells in RA patients with DAS28 ≤3.2, consequently restoring a healthy balance of Th17/Treg cells, which might improve the likelihood of long-term and sustained clinical remission and reduce the probability of disease flare-ups in RA. PMID: 31074719 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

High LDL-C levels attenuate onset of inflammation and cartilage destruction in antigen-induced arthritis.
CONCLUSIONS: Taken together, our findings suggest that high levels of LDL/oxLDL during inflammation, dampen the initiation and chronicity of joint inflammation and cartilage destruction in AIA by regulating macrophage FcγR expression. PMID: 31074720 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Retrospective evaluation of patient profiling and effectiveness of apremilast in an Italian multicentric cohort of psoriatic arthritis patients.
CONCLUSIONS: In our real-life analysis apremilast was mainly used in oligoarticular PsA carrying comorbidities leading to contraindications to biologics. Effectiveness and safety profiles were consistent with clinical trials. PMID: 31074721 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Elevated serum levels of alarmin S100A8/A9 in patients with hand osteoarthritis.
Authors: Addimanda O, Pulsatelli L, Vogl T, Roth J, Mancarella L, Assirelli E, Ramonda R, Fioravanti A, Meliconi R PMID: 31074722 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

HIV-associated vasculitis. Part II: histologic and angiographic diagnostic reconfirmation after an uncontrolled HIV infection and fatal outcome.
Authors: Laurent C, Marçal AL, Prieto-González S, Balagué O, Morales X, Darnell A, Ripoll E, Cid MC, Hernández-Rodríguez J PMID: 31074723 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comments on the giant cell arteritis probability score.
Authors: Ing E, Sambhi G, Torun N, Pagnoux C PMID: 31074724 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Progranulin-autoantibodies in sera of rheumatoid arthritis patients negative for rheumatoid factor and anti-citrullinated peptide antibodies.
CONCLUSIONS: These data suggest that the determination of PGRN-abs in seronegative RA patients may reduce their seronegative status. Further studies are required to evaluate PGRN-abs as a potential diagnostic marker in RA. PMID: 31074725 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Presence of intraepithelial B-lymphocytes is associated with the formation of lymphoepithelial lesions in salivary glands of primary Sj ögren's syndrome patients.
CONCLUSIONS: We conclude there is an association between presence of intraepithelial B-lymphocytes and the formation of LELs in salivary glands of pSS patients. PMID: 31074726 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The influence of immunosuppressants on the non-melanoma skin cancer among patients with systemic lupus erythematosus and primary Sj ögren's syndrome: a nationwide retrospective case-control study in Taiwan.
CONCLUSIONS: The patients with SLE or pSS had significantly increased associations with NMSC, especially those receiving higher cumulative doses of corticosteroids and hydroxychloroquine. PMID: 31074727 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The role of osteopontin as a candidate biomarker of renal involvement in systemic lupus erythematosus.
Authors: Spinelli FR, Garufi C, Truglia S, Pacucci VA, Morello F, Miranda F, Perricone C, Ceccarelli F, Valesini G, Conti F Abstract OBJECTIVES: Kidney biopsy is the gold standard for the diagnosis of lupus nephritis (LN). Conventional biomarkers of disease activity or renal function, such as complement levels, anti-dsDNA, serum creatinine, urinary sediment and proteinuria, do not have a sensitive diagnostic and prognostic value, therefore new biomarkers are needed to help predict or monitor LN. Osteopontin (OPN) is a pro-inflammatory molecule detectable in serum and renal tissue. The aim of this study was to evalu...
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficacy and adverse effects of methotrexate compared with azathioprine in the antisynthetase syndrome.
CONCLUSIONS: AZA and MTX showed similar efficacy and adverse events in patients with ASyS. Pneumonitis is a rare but important event in patients receiving MTX. PMID: 31074729 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 12, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Health-related quality of life, illness perception, coping strategies and the distribution of dependency in autoinflammatory diseases.
Authors: Cipolletta S, Giudici L, Punzi L, Galozzi P, Sfriso P PMID: 31025921 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Interleukin-6 expression in inflamed and non-inflamed temporal arteries from patients with giant cell arteritis.
CONCLUSIONS: Interleukin-6 expression does not increase the sensitivity of temporal artery biopsy in patients with giant cell arteritis who have morphologically uninflamed arteries. PMID: 31025922 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Adiponectin promotes fibroblast-like synoviocytes producing IL-6 to enhance T follicular helper cells response in rheumatoid arthritis.
CONCLUSIONS: Our study demonstrated that AD-stimulated RA FLSs promote Tfh cell generation, which is mainly mediated by the secretion of soluble factor IL-6. This finding reveals a novel mechanism for AD in RA pathogenesis. PMID: 31025923 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 27, 2019 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research