An increased major vessel uptake by 18F-FDG-PET/CT in NIH criteria clinical inactive patients with Takayasu's arteritis.
CONCLUSION: 18FDG-PET/CT appears to be a promising technique for the diagnosis and assessment of disease activity in patients of TAK, even those considered to be inactive by the NIH criteria. However, it needs to be validated in larger groups for cost-effectiveness and sensitivity to change. PMID: 29465347 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased circulating CD14brightCD16+ intermediate monocytes are regulated by TNF- α and IL-6 axis in accordance with disease activity in patients with rheumatoid arthritis.
CONCLUSIONS: We showed that the population of CD14brightCD16+ monocytes significantly decreased with the change of disease activity by key cytokines, IL-6 or TNF-α signal blockade in RA. This result indicates that the proportion of those monocytes is important for reflecting disease activity in RA. PMID: 29465348 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association of depression with socioeconomic status, anticardiolipin antibodies, and organ damage in patients with systemic lupus erythematosus: results from the KORNET registry.
CONCLUSIONS: Our results show that depression is prevalent in patients with SLE and multiple factors are associated with depression in SLE. These data could help guide target programmes for those at high risk of depression in SLE. PMID: 29465349 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The association of endothelial nitric oxide synthase gene single nucleotide polymorphisms with paediatric systemic lupus erythematosus.
CONCLUSIONS: SNP rs1808593 GT genotype is significantly higher than that in the control group, which may indicate that this genotype increases the risk of pSLE, especially in boys, and also this genotype might increase the risk of central nervous system involvement. Therefore, eNOS gene SNP rs1808593 genotype may have an important role in predicting the occurrence of pSLE and central nervous system complications in pSLE. PMID: 29465350 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Increased remodelling of interstitial collagens and basement membrane is suppressed by treatment in patients with rheumatoid arthritis: serological evaluation of a one-year prospective study of 149 Japanese patients.
Authors: Gudmann NS, Hirata S, Karsdal MA, Kubo S, Bay-Jensen AC, Tanaka Y Abstract OBJECTIVES: This prospective study aimed to use serological biomarkers for evaluation of, connective tissue turnover, in a population of 149 Japanese patients with rheumatoid arthritis (RA). It was aimed to investigate how the connective tissue was affected by treatment at follow-up after 1 year (+/- 6 weeks) with either methotrexate (n=23) alone, or in combination with: adalimumab (n=49), tofacitinib (n=27) or tocilizumab (n=50). METHODS: Clinical characteristics were collected and connective tissue turnover, was evaluated by 4...
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Immune response against the coiled coil domain of Sj ögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.
CONCLUSIONS: Our data demonstrate that epitope specificity of anti-Ro52 antibodies plays a critical role in the induction of glandular dysfunction. Clearly, screening Sjögren's syndrome patients for relative levels of Ro52 domain specific antibodies will be more informative for associating anti-Ro52 with clinical measures of the disorder. PMID: 29465352 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum IgG ACPA-IgM RF immune complexes were detected in rheumatoid arthritis patients positive for IgM ACPA.
CONCLUSIONS: In an attempt to detect IgM ACPA, we mostly revealed false positive reactions due to the presence of IgM molecules, which were not specific for citrullinated proteins, and IgG ACPA-IgM RF immune complex. The latter complex had been proposed to play a role in the pathogenesis of RA, and here, for the first time, we have demonstrated its presence in the sera of RA patients. PMID: 29465353 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in American and Israeli rheumatoid arthritis patients.
Authors: Merdler-Rabinowicz R, Hassidim A, Hellou R, Merdler I, Hauser W, Ablin JN Abstract OBJECTIVES: Psychological stress is thought to play a major role in the development and exacerbation of autoimmune diseases in general, as well as in rheumatoid arthritis (RA) in particular. The aims of the current study are to compare retrospective self-reports of childhood maltreatment and lifetime major life/traumatic experiences of American and Israeli RA patients, using standardised instruments, while adjusting for concomitant mental disorders and psychological distress, in order to rule out their part in the subjective...
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts.
CONCLUSIONS: This first report on ARL15 expression in RASF and its likely role in inflammation and metabolic syndromes through a TNF independent pathway, encourages hypothesis-free studies to identify additional pathways underlying RA disease biology. PMID: 29465355 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Does "time heal all wounds" still have a future in osteoarthritis?
Does "time heal all wounds" still have a future in osteoarthritis? Clin Exp Rheumatol. 2018 Feb 15; Authors: Villafañe JH PMID: 29465356 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Molecular recognition patterns of anti-topoisomerase I-antibodies in patients with systemic sclerosis before and after autologous stem cell transplantation.
CONCLUSIONS: Reactivity towards topo-I-epitopes is heterogeneous in SSc, but peptide 39 (aa647-671) may be another immunodominant epitope besides the published epitope aa489-573. Antibody reactivity to this peptide 39 was higher in group 2- than in group 1-patients. Peptide recognition pattern did not change after aSCT. PMID: 29465357 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Bickerstaff brainstem encephalitis in a patient with ankylosing spondylitis on tumour necrosis factor-alpha inhibitor.
Authors: Kim M, Kim MJ, Suh YS, Kim HO, Lee SI, Cheon YH PMID: 29465358 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Socio-economic inequalities in occurrence and health care costs in rheumatic and musculoskeletal diseases: results from a Spanish population-based study including 1.9 million persons.
CONCLUSIONS: Socio-economic deprivation is associated with increased occurrence of all RMDs, and in most cases more deprived patients incur higher health care costs. PMID: 29465359 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum soluble interleukin-2 receptor is a useful biomarker for disease activity but not for differential diagnosis in IgG4-related disease and primary Sj ögren's syndrome adults from a defined population.
Serum soluble interleukin-2 receptor is a useful biomarker for disease activity but not for differential diagnosis in IgG4-related disease and primary Sjögren's syndrome adults from a defined population. Clin Exp Rheumatol. 2018 Feb 15; Authors: Akiyama M, Sasaki T, Kaneko Y, Yasuoka H, Suzuki K, Yamaoka K, Takeuchi T Abstract OBJECTIVES: To identify biomarkers for disease activity in IgG4-related disease (IgG4-RD) and primary Sjögren's syndrome (pSS). METHODS: Forty-three consecutive treatment-naïve patients with IgG4-RD, 62 patients with pSS, and 5 patients with sicca syndrome were...
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Superior oblique myositis causing acquired Brown's syndrome as the first manifestation of primary Sj ögren's syndrome.
Superior oblique myositis causing acquired Brown's syndrome as the first manifestation of primary Sjögren's syndrome. Clin Exp Rheumatol. 2018 Feb 14; Authors: Moon JS, Shin SY PMID: 29465361 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Development of systemic sclerosis in transgender females: a case series and review of the literature.
CONCLUSIONS: This case series suggests that the hormonal modification as part of gender transition may be relevant in development of SSc. No further conclusions can be drawn on the continuation or not of HT. PMID: 29465362 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Inhibitory effect and mechanism of 1,25-dihydroxy vitamin D3 on RANKL expression in fibroblast-like synoviocytes and osteoclast-like cell formation induced by IL-22 in rheumatoid arthritis.
Authors: Wen H, Liu Y, Li J, Wei D, Liu D, Zhao F Abstract OBJECTIVES: To explore the inhibitory effect and mechanism of 1,25-dihydroxy vitamin D3 (l,25(OH)2D3) on receptor activator of nuclear factor-κB ligand (RANKL) expression in fibroblast-like synoviocytes (FLSs) and osteoclastogenesis induced by interleukin (IL)-22 in patients with rheumatoid arthritis (RA). METHODS: Fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLSs) were cultured and stimulated for RANKL expression with IL-22 in the absence or presence of various concentrations of l,25(OH)2D3, and JAK-2 inhibitor or p38 ...
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Autologous fat transfer in the successful treatment of upper limb linear morphoea.
Authors: Mura S, Fin A, Parodi PC, Denton CP, Howell KJ, Rampino Cordaro E PMID: 29465364 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Polyarteritis nodosa revisited: a review of historical approaches, subphenotypes and a research agenda.
Authors: Karadag O, Jayne DJ Abstract Polyarteritis nodosa (PAN) is a rare form of primary systemic vasculitis with heterogeneous presentations, treatments and disease course. Historical approaches to classification and diagnostic terminology are reviewed. Since differentiation of PAN from microscopic polyangiitis (MPA) and other ANCA vasculitides by the Chapel Hill conference statements, and with hepatitis associated PAN defined as a secondary vasculitis, the phenotyping and subclassification of PAN has received little attention. Monogenic disorders similar to PAN have been described (familial Mediterranean fever,...
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cancer development in Korean patients with ANCA-associated vasculitis: a single centre study.
CONCLUSIONS: The risk of cancer is low in Korean patients with AAV. PMID: 29465366 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Proprotein convertase enzyme FURIN is upregulated in primary Sj ögren's syndrome.
CONCLUSIONS: The proprotein convertase FURIN is significantly upregulated in pSS. Elevated FURIN levels associate with high levels of the Th1 type cytokine IFN-γ and long duration of dry eye symptoms. Patients with high FURIN levels show signs of lower disease activity suggesting that FURIN might have a protective role in pSS. PMID: 29465367 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Comparative effectiveness of glucosamine, chondroitin, acetaminophen or celecoxib for the treatment of knee and/or hip osteoarthritis: a network meta-analysis.
CONCLUSIONS: Given the effectiveness of these non-steroidal anti-inflammatory drugs and symptomatic slow-acting drugs, oral celecoxib is more effective than placebo on relieving pain and improving physical function, followed by the combination of glucosamine and chondroitin. Acetaminophen is likely the least efficacious intervention option. This information, accompanied by the tolerability and economic costs of the included treatments, would be conducive to making decisions for clinicians. PMID: 29465368 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Altered gene expression profiles of histone lysine methyltransferases and demethylases in rheumatoid arthritis synovial fibroblasts.
CONCLUSIONS: The study findings suggest that the HKM-modifying enzymes are involved in the alteration of HKM, which results in changes in the gene expression of RASFs. PMID: 29465369 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The initial predictors of death in 153 patients with ANCA-associated vasculitis in a single Korean centre.
CONCLUSIONS: The overall mortality rate was 9.2% and 10-year cumulative patient survival rate was 92.8%. At diagnosis, FFS (2009) ≥ 2 and DAH were independent predictors of death during the follow-up in Korean patients with MPA, GPA and EGPA. PMID: 29465370 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Long-term effects of the new direct antiviral agents (DAAs) therapy for HCV-related mixed cryoglobulinaemia: a multicentre open-label study.
CONCLUSIONS: DAA therapy is safe and effective to eradicate HCV in MC, but seems associated with satisfactory clinical response in mild or moderate cryoglobulinaemic vasculitis and no response in B-NHL. PMID: 29465371 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tocilizumab for the treatment of patients with rheumatoid arthritis and interstitial lung diseases: a case series.
Authors: Manfredi A, Sebastiani M, Cassone G, Colaci M, Sandri G, Ferri C PMID: 29465372 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Anti-alpha-enolase antibodies in Beh çet's disease: a marker of mucocutaneous and articular disease activity?
Anti-alpha-enolase antibodies in Behçet's disease: a marker of mucocutaneous and articular disease activity? Clin Exp Rheumatol. 2018 Feb 07; Authors: Prado LL, Goncalves CR, Viana VT, Saad CGS, Bonfa E Abstract OBJECTIVES: To assess IgM anti-alpha-enolase antibodies (AAEA) in systemic Behçet's disease (BD) and its possible association with clinical manifestations and disease activity. METHODS: Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy contro...
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

No specific imaging pattern can help differentiate IgG4-related disease from idiopathic retroperitoneal fibrosis: 18 histologically proven cases.
CONCLUSIONS: After ruling out all known causes of RPF, retroperitoneal biopsy is still necessary to ascertain the diagnosis of IgG4-RD-RPF. No specific pattern can be used to distinguish between IgG4-RD-RPF and iRFP. PMID: 29465374 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Pauci-immune crescentic glomerulonephritis in a patient with B-lymphocyte poly/autoreactivity.
Authors: Moutsopoulos HM, Gakiopoulou H PMID: 29465375 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Efficient detection of pulmonary arterial hypertension using serum haptoglobin level and cardiac MRI in patients with connective tissue diseases: a pilot study.
Authors: Nakamura H, Kato M, Nogochi A, Ohira H, Tsujino I, Atsumi T PMID: 29465376 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 24, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Disease activity and dropout in young persons with juvenile idiopathic arthritis in transition of care: a longitudinal observational study.
CONCLUSIONS: The process of transition in JIA is not associated with an increase in disease activity, however, this period carries a risk for drop out especially in patients with low disease activity. PMID: 29461957 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 21, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Gout in Duke Federico of Montefeltro (1422-1482): a new pearl of the Italian Renaissance.
Authors: Fornaciari A, Giuffra V, Armocida E, Caramella D, Rühli FJ, Galassi FM Abstract The article examines the truthfulness of historical accounts claiming that Renaissance Duke Federico of Montefeltro (1422-1482) suffered from gout. By direct paleopathological assessment of the skeletal remains and by the philological investigation of historical and documental sources, primarily a 1461 handwritten letter by the Duke himself to his personal physician, a description of the symptoms and Renaissance therapy is offered and a final diagnosis of gout is formulated. The Duke's handwritten letter offers a rare test...
Source: Clinical and Experimental Rheumatology - February 21, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

One year in review 2017: spondyloarthritis.
Authors: Terenzi R, Monti S, Tesei G, Carli L Abstract The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority of people with this disease have either psoriatic arthritis or axial spondyloarthritis, which includes ankylosing spondylitis. Less common subgroups are enteropathic SpA, which is associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis), reactive arth...
Source: Clinical and Experimental Rheumatology - February 21, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

An overview of pathways encoding nociception.
Authors: Woller SA, Eddinger KA, Corr M, Yaksh TL PMID: 29461960 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 21, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Long-term continuation of methotrexate therapy in giant cell arteritis patients in clinical practice.
Authors: Leon L, Rodriguez-Rodriguez L, Freites D, Arietti L, Morado I, Vadillo C, Lamas JR, Fernandez B, Jover JA, Abasolo L PMID: 29461961 [PubMed - in process] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - February 21, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Reduction or cessation of antiviral agents in hepatitis B virus carriers treated with biologic agents.
Authors: Ghang B, Lee D, Hwang I, Lee CK, Yoo B, Kim YG PMID: 29352838 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The new frontier of imaging: the micron.
Authors: Aringhieri G, Vitali S, Rossi P, Caramella D PMID: 29352839 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Serum aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1), a novel disease activity predictive biomarker of systemic lupus erythematosus.
Authors: Ahn SS, Hong SH, Park Y, Jung SM, Song JJ, Park YB, Lee SW, Park SG Abstract OBJECTIVES: Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) has been reported to have pro-inflammatory properties. The aim of this study was to evaluate the clinical significance of serum AIMP1 in patients with systemic lupus erythematosus (SLE). METHODS: Serum levels of AIMP1 were measured in 160 patients with SLE using a human AIMP1 ELISA kit. Eighty patients were classified as active SLE (SLEDAI-2K ≥ 5), and 80 patients were classified as stable SLE. Correlation between serum AIMP1, SLE d...
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Predict rheumatoid arthritis conversion from undifferentiated arthritis with dynamic contrast-enhanced MRI and laboratory indexes.
Authors: Lei X, Li H, Zhan Y, Qu J Abstract OBJECTIVES: To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). METHODS: A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis. RESULTS: Wash-in rate and anti-cyclic citrullinated peptide (ant...
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Amylin in the insulin resistance of patients with rheumatoid arthritis.
CONCLUSIONS: IR in RA does not appear to be mediated by amylin. This would imply that the mechanisms associated with IR in RA patients differ from those at work in type 2 diabetes. PMID: 29352842 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Tocilizumab after a first-line with anti-TNF in rheumatoid arthritis: a cost-consequence analysis in the Italian setting.
The objective of this study was a health economic assessment in Italy. METHODS: The study was conducted using a pharmacoeconomic model with a 3-year time horizon. Effectiveness was measured as days gained in low disease activity (LDA; DAS28-ESR
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Hypoalbuminaemia in antineutrophil cytoplasmic antibody-associated vasculitis: incidence and significance.
The objective of this study was to investigate the significance of hypoalbuminaemia in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: Data of 117 AAV patients were analysed retrospectively. The relationship between hypoalbuminaemia and disease severity were studied. The influence of albumin on the pathogenetic role of ANCA was investigated in vitro. RESULTS: Among all patients, 52 had light hypoalbuminaemia (30g/L
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Rapidly progressive glomerulonephritis caused by overlap syndrome of IgG4-related tubulointerstitial nephritis and myeloperoxidase-antineutrophil cytoplasmic antibody-associated necrotising glomerulonephritis.
Authors: Watanabe T, Kanda M, Fukaya S, Ogawa Y, Akikawa K PMID: 29352845 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The Janus kinase inhibitor tofacitinib inhibits TNF- α-induced gliostatin expression in rheumatoid fibroblast-like synoviocytes.
CONCLUSIONS: JAK/STAT activation plays a pivotal role in TNF-α-mediated GLS up-regulation in RA. Suppression of GLS expression in FLSs has been suggested to be one of the mechanisms through which tofacitinib exerts its anti-inflammatory effects. PMID: 29352846 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Switching to biosimilar infliximab: real world data in patients with severe inflammatory arthritis.
Authors: Holroyd CR, Parker LM, Bennett S, Zarroug J, Underhill C, Davidson B, Armstrong R, Harvey NC, Dennison E, Cooper C, Edwards CJ PMID: 29352847 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Association between perceived level of stress, clinical characteristics and psychopathological symptoms in women with systemic lupus erythematosus.
CONCLUSIONS: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting. PMID: 29352848 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Impact of vasculitis on employment and income.
CONCLUSIONS: Due to their vasculitis, patients frequently suffer substantial limitations in work and productivity, and personal income loss. PMID: 29352849 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Ultrasound to detect involvement of vertebral artery in giant cell arteritis.
Authors: Gehlen M, Schaefer N, Schwarz-Eywill M, Maier A PMID: 29352850 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Prostate cancer-associated polyarteritis nodosa: improvement of clinical manifestations after prostatectomy.
Authors: Watanabe T, Kanda M, Kikuchi K PMID: 29352851 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Associations between the SLC22A12 gene and gout susceptibility: a meta-analysis.
CONCLUSIONS: The rs475688 polymorphism is associated with gout susceptibility. The correlation between rs3825016 polymorphism of SLC22A12 and hyperuricaemia susceptibility is possible. PMID: 29352852 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - January 22, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research