A 6-year review of acute post-streptococcal glomerulonephritis at a public children ’s hospital in Cape Town, South Africa
ConclusionsChildhood APSGN remains an important health problem in South Africa (SA) with favourable outcomes in most, apart from those with crescentic glomerulonephritis who progressed to kidney failure.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 19, 2024 Category: Urology & Nephrology Source Type: research
Evaluation of the Optimal Duration of Thumb Cupping Therapy for Frozen Shoulder by Thermal Metabolic Imaging
CONCLUSIONS: Through TMI, it is confirmed that thumb cupping therapy with a duration of 10 min contributes to the highest efficacy and safety for patients with FS.PMID:38639621 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Yan Liu Yanli Xia Hongwei Chen Yuanyuan Zhu Chaoju Zhang Source Type: research
Comparative Analysis of Clinical Outcomes: Posterior Cervical Endoscopic Discectomy versus Fenestration Laminectomy Discectomy for Cervical Disc Herniation
CONCLUSION: PCED showed favorable long-term clinical efficacy in the treatment of CDH, with excellent recovery and high safety. Compared to FLD, PCED resulted in reduced intraoperative blood loss, shorter incision length, and faster recovery. It also led to improved pain scores, functional outcomes, and quality of life measures. The absence of postoperative complications further supports the use of PCED as an effective treatment option for CDH.PMID:38639610 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Minhong Zhou Linxia Wang Xixi Xu Lijuan Wang Peifang Wang Source Type: research
A practical guide for the use of apalutamide for non-metastatic castration-resistant prostate cancer in Australia
Asia Pac J Clin Oncol. 2024 Apr 19. doi: 10.1111/ajco.14054. Online ahead of print.ABSTRACTStudies of patients with castrate-resistant prostate cancer at high risk of developing overt metastases but with no current evidence of evaluable disease on computed tomography or bone scan non-metastatic castrate-resistant prostrate cancer have demonstrated increased metastasis-free survival and overall survival following treatment with the next-generation oral anti-androgen apalutamide (in addition to therapies that aim to lower testosterone to castrate levels) or luteinizing hormone-releasing hormone antagonist or surgical castrat...
Source: Clinical Prostate Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Gavin Marx Simon Chowdhury Laurence Krieger Elizabeth Hovey Jeremy Shapiro Ben Tran Thean Hsiang Tan Siobhan Ng Henry H Woo Source Type: research
Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research
Skin Barrier in Atopic Dermatitis
A compromised permeability barrier is a hallmark of atopic dermatitis (AD). Localized to the outermost skin layer, the stratum corneum (SC) is critically dependent on terminal differentiation of epidermal keratinocytes, which transform into protein-rich corneocytes surrounded by extracellular lamellae of unique epidermal lipids, conferring permeability barrier function. These structures are disrupted in AD. A leaky barrier is prone to environmental insult, which in AD elicits type 2 –dominant inflammation, in turn resulting in a vicious cycle further impairing the SC structure. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Authors: Matthias Schmuth, Sonja Eckmann, Verena Moosbrugger-Martinz, Daniela Ortner-Tobider, Stefan Blunder, Thomas Trafoier, Robert Gruber, Peter M. Elias Tags: Atopic Dermatitis Spotlight Source Type: research
Editorial Board
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Source Type: research
Subscription Information
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Source Type: research
Table of Contents
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Source Type: research
Clinical Snippets
Schuler et al penned an in-depth review of atopic dermatitis (AD) to describe the intersection between the genetic features, immunopathogenesis, environmental influences, and relationship to other atopic diseases. Heritability of this disease is as high as 80%, stemming from null sequence variants in the ski n barrier protein FLG as well as other epidermis-related factors. Dysfunction of immune cells (T helper [Th]2 cells, dendritic cells, mast cells, basophils, and keratinocytes) and cytokines (IL-2, IL-4, and IL-13) has also been rigorously explored in AD. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research
Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding
The progress in our understanding of atopic dermatitis (AD) (atopic eczema) in the last 10 years has been remarkable. Nearly half of the scientific papers ever published on AD have been written in the last 10 years. This contribution of knowledge, in parallel with technological and pharmaceutical progress, has transformed our ability to treat some of the most severe forms of AD. Notably, we have seen the advent of biologics such as the anti –IL-4 receptor biologic dupilumab (Simpson et al, 2016), 2 anti–IL-13 agents (tralokinumab [Wollenberg et al, 2021] and lebrikizumab [Silverberg et al, 2023]), and small-molecula...
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Authors: Sara J. Brown, Johann E. Gudjonsson Tags: Editorial Source Type: research
Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin
The epidermis is the body ’s first line of protection against dehydration and pathogens, continually regenerating the outermost protective skin layers throughout life. During both embryonic development and wound healing, epidermal stem and progenitor cells must respond to external stimuli and insults to build, maintain, an d repair the cutaneous barrier. Recent advances in CRISPR-based methods for cell lineage tracing have remarkably expanded the potential for experiments that track stem and progenitor cell proliferation and differentiation over the course of tissue and even organismal development. (Source: Journal of In...
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Authors: Jenny F. Nathans, Jessica L. Ayers, Jay Shendure, Cory L. Simpson Tags: Methods and Techniques for Skin Research Source Type: research
Brrr - Understanding and Identifying Uremic Frost - An Icy Dermatologic Manifestation at the End of Life
1. Identify uremic frost from visual cues.2. Describe the mechanism for development of uremic frost and appropriate management. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Rachel Pallay, John Liantonio Source Type: research
Anoikis patterns via machine learning strategy and experimental verification exhibit distinct prognostic and immune landscapes in melanoma
ConclusionsIn this study, we successfully established a prognostic anoikis-connected signature using machine learning. This model may aid in evaluating patient prognosis, clinical characteristics, and immune treatment modalities for melanoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1571: Current State of Melanoma Therapy and Next Steps: Battling Therapeutic Resistance
Chen
Melanoma is the most aggressive and deadly form of skin cancer due to its high propensity to metastasize to distant organs. Significant progress has been made in the last few decades in melanoma therapeutics, most notably in targeted therapy and immunotherapy. These approaches have greatly improved treatment response outcomes; however, they remain limited in their abilities to hinder disease progression due, in part, to the onset of acquired resistance. In parallel, intrinsic resistance to therapy remains an issue to be resolved. In this review, we summarize currently available therapeutic options for melanoma t...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Fateeva Eddy Chen Tags: Review Source Type: research
