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Effects of Omega-3 Fatty Acids Against Chemotherapy-induced Mucositis: A Double-blind Randomized Clinical Trial.
CONCLUSIONS: Omega-3 fatty acids are a safe, effective method for preventing and treating oral mucositis in patients receiving mucotoxic cancer chemotherapy. PMID: 29324423 [PubMed - in process] (Source: Wounds)
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

Larval Therapy for Chronic Cutaneous Ulcers: Historical Review and Future Perspectives.
Authors: Raposio E, Bortolini S, Maistrello L, Grasso DA Abstract Cutaneous ulcers tend to become chronic and have a profound impact on quality of life. These wounds may become infected and lead to greater morbidity and even mortality. In the past, larvae (ie, maggots) of certain common flies (Lucilia sericata and Lucilia cuprina) were considered useful in ulcer management because they only remove necrotic tissue while promoting healthy tissue in the wound bed, thus helping wounds heal faster. Recently, maggots from several other fly species (Calliphora vicina, Calliphora vomitoria, Phormia regina, Chrysomya albice...
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

Comparison of a Saline-coupled Bipolar Sealer Versus Traditional Electrosurgery in a Porcine Model of Chronic Wound Healing.
CONCLUSIONS: Overall, both devices elicited similar progression of healing by 8 weeks. The SCBS produced a deeper thermal effect in a shorter treatment time and improved myofiber regeneration compared with ES and had an equivalent overall course of healing. PMID: 29324425 [PubMed - in process] (Source: Wounds)
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

A Sweet Solution: The Use of Medical-grade Honey on Oral Mucositis in the Pediatric Oncology Patient.
CONCLUSIONS: Leptospermum honey paste proved to be effective in all participating patients. PMID: 29324426 [PubMed - in process] (Source: Wounds)
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

Lemons in the Arizona Sunshine: The Effects of Furocoumarins Leading to Phytophotodermatitis and Burn-like Injuries.
CONCLUSIONS: Burn-like lesions caused by furocoumarins after cutaneous absorption and UV-A exposure are known clinical entities in Arizona. The sequential progression from erythema to blisters equivalent to second-degree burn-like lesions to cutaneous hyperpigmentation is a well-described clinical triad. Meticulous wound care and pain control for the treatment of these burn-like lesions are essential as is the need for the wound care specialist to be well versed on this topic to quickly identify the etiology of the injury, thereby avoiding misdiagnosing the patient with nonaccidental traumatic injuries. PMID: 29324427 ...
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

Malignant Transformation of a Site of Prior Diabetic Foot Ulceration to Verrucous Carcinoma: A Case Report.
Authors: Priesand SJ, Holmes CM Abstract The case of a 62-year-old Caucasian man with type 1 diabetes who developed malignant transformation of an area of prior diabetic foot ulceration (DFU) is reported. He had significant hallux valgus deformity, multiple episodes of healing and breakdown, and eventual transformation to verrucous carcinoma (VC). This case report highlights the malignant transformation of a site of previous DFU to VC, which, to the best of the authors' knowledge, has not yet been described in the literature. There has been little research performed that examines VC in the diabetic population. This...
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

A Pilot Clinical Study of a Safe and Efficient Stool Management System in Patients With Fecal Incontinence.
CONCLUSIONS: This study, along with pilot clinical findings, suggests that this technology minimizes the pressure exerted on the rectal wall. There were significantly fewer forces against the anorectal mucosa compared with the cuff-based catheter during insertion, withdrawal, and accidental expulsion. PMID: 29324429 [PubMed - in process] (Source: Wounds)
Source: Wounds - January 13, 2018 Category: General Medicine Tags: Wounds Source Type: research

Low-intensity Exercise Accelerates Wound Healing in Diabetic Mice.
CONCLUSIONS: In this preliminary investigation, low-intensity exercise accelerated wound healing rates in diabetic mice but high-intensity exercise did not. Future studies should investigate the mechanisms behind this effect and evaluate different intensities of exercise on wound healing in humans with type 2 diabetes. PMID: 29166252 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Hepatitis C Virus: Patients' Risk Factors and Knowledge in an Urban Clinic Providing Wound Care.
CONCLUSIONS: This urban clinic had patients with multiple HCV risk factors; they often lacked HCV screening and/or referral for treatment. Their HCV knowledge was generally low. As a major public health problem that could impact wound healing, wound care practitioners should ask patients about their HCV status, encourage HCV screening and care, and provide HCV information. PMID: 29166253 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds.
Authors: Bohn GA, Schultz GS, Liden BA, Desvigne MN, Lullove EJ, Zilberman I, Regan MB, Ostler M, Edwards K, Arvanitis GM, Hartman JF Abstract Normal wound healing is accomplished through a series of well-coordinated, progressive events with overlapping phases. Chronic wounds are described as not progressing to healing or not being responsive to management in a timely manner. A consensus panel of multidisciplinary wound care professionals was assembled to (1) educate wound care practitioners by identifying key principles of the basic science of chronic wound pathophysiology, highlighting the impact of metalloprotei...
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Chemical Burns Following Massage With Chopped Pulsatilla koreana.
Authors: Song J, Tae S, Joo H, Lee SY, Sung KY Abstract Herbal massage is commonly used for cosmetic and antirheumatic purposes in the Republic of Korea. Cutaneous burns can complicate herbal massages, but this is a very rare occurrence. Pulsatilla koreana, the Korean pasque flower, is a species of the genus Pulsatilla from the Ranunculaceae family. It is a perennial plant native to Korea, where it is used in herbal and folk medicine for its antipyretic, analgesic, anti-inflammatory, astringent, and hemostatic effects. Three cases of burns as a result of herbal massages with Pulsatilla koreana are presented herein ...
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Infection-free Clinical Response Among Patients With Hidradenitis Suppurativa Who Were Treated With Adalimumab: Results from Two Phase 3 Studies.
The objective of this study is to assess the rates of infection-free achievement of hidradenitis suppurativa clinical response (HiSCR) using integrated data from 2 phase 3, placebo-controlled trials, PIONEER I and II. MATERIALS AND METHODS: Analyses from the first 12 weeks of both studies were examined. Patients were randomized to receive adalimumab (ADA) or placebo, and they then were assessed in the clinic at weeks 0, 2, 4, 8, and 12. All reports of an adverse or serious adverse event and infection were classified as treatment-emergent adverse events (TEAEs). The HiSCR was evaluated as the primary endpoint; infection...
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Raoultella planticola: A Rare Cause of Wound Infection.
Authors: Kalaria SS, Elliott K, Combs N, Phillips LG Abstract Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. She was treated successfully with local wound care using dehydrated human amnion/chorion and ...
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Application of a Skin Adhesive to Maintain Seal in Negative Pressure Wound Therapy: Demonstration of a New Technique.
CONCLUSIONS: Maintaining an airtight seal in NPWT is crucial to wound healing. Cyanoacrylate tissue adhesives appear to be a safe and viable option for creating a durable seal in NPWT for wounds in anatomically difficult locations. PMID: 29166258 [PubMed - in process] (Source: Wounds)
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Clinical Outcome of Achilles Tendon Repair Using Viable Intact Cryopreserved Umbilical Tissue Versus Standard of Case.
CONCLUSIONS: Clinical outcomes of this study support the use of vCUT for augmentation of Achilles tendon repair. PMID: 29166259 [PubMed - in process] (Source: Wounds)
Source: Wounds - November 24, 2017 Category: General Medicine Tags: Wounds Source Type: research

Bee or Wasp Sting.
Authors: Hon KL, Leung AKC Abstract While jogging in a local park in Hong Kong, a 55-year-old, previously healthy man was stung on the ventral aspect of his right wrist. The tiny stinger was gently removed with nail cutters and examined under a microscope at 80x magni cation; plucking the stinger is ill- advised as this may inject more venom into the wounded site. Two days after stinging, the microscopic appearance of the stinger con rmed the diagnosis to be from a bee instead of a wasp or other insect. A simple method of con rming the nature of insect stings and an overview of Hymenoptera stings and their manageme...
Source: Wounds - November 11, 2017 Category: General Medicine Tags: Wounds Source Type: research

Perceived Concerns of Patients at Risk for Lower Extremity Amputation.
CONCLUSIONS: It is the authors' hope that this investigation provides wound care professionals with information that will benefit their approach to the education and treatment of patients at risk for amputation as well as lead to future investigations into the emotional and psychological state of patients with chronic lower extremity wounds. PMID: 29091033 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Updating the Diabetic Foot Treatment Algorithm: Recommendations on Treatment Using Advanced Medicine and Therapies.
CONCLUSIONS: Treatment for DFUs should start when a possible pre-ulcer is noticed. This prophylactic treatment may reduce development of more severe DFUs. Once a DFU has developed, care should be optimized for both the patient and the wound bed. While these treatment recommendations are focused solely on DFUs, they may be expanded for use in other foot/leg pressure ulcers. PMID: 29091034 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Psychosocial Aspects in Patients With Chronic Leg Ulcers.
Authors: Platsidaki E, Kouris A, Christodoulou C Abstract Chronic leg ulcers persist for> 6 weeks and show no tendency to heal after 3 or more months. They can be distressing to patients, both directly through physical symptoms caused by the disease and indirectly through limitations on work capacity, social activity, and personal hygiene. The quality of life (QoL) of patients with leg ulcers can be impaired by a complex set of aspects. Restrictions in their ability to perform paid employment, handle household duties, and engage in personal hygiene adversely affect patients' QoL. Patients with chronic leg ulcers...
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

A Pilot Study to Evaluate the Effects of Perfusion-decellularized Porcine Hepatic-derived Wound Matrix on Difficult-to-heal Diabetic Foot Ulcers.
CONCLUSIONS: These results suggest that PDPHD-WM may be an appropriate modality to treat difficult-to-heal DFUs, and a larger randomized placebo-controlled trial should be performed to investigate these findings. To the best of the authors' knowledge, this is the first collected data on using PDPHD-WM to treat DFUs. PMID: 29091040 [PubMed - in process] (Source: Wounds)
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Evidence Corner: Nutrition Affects Chronic Wound Outcomes.
Authors: Bolton L PMID: 29091041 [PubMed - in process] (Source: Wounds)
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Editorial Message: Self-Reflection.
Authors: Treadwell T PMID: 29091042 [PubMed - in process] (Source: Wounds)
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Off-label Usage of Absorbable Beads Containing Antibiotics for Prevention of Surgical Site Infections.
Authors: Trujillo JM, Logue ME, Kunkel R, Demas CP Abstract Surgical site infections account for about 17% of all nosocomial infections, second only to urinary tract infections. Antibiotic beads deliver high local antibiotic concentrations and maintain low systemic levels. The authors assessed the efficacy of calcium sulfate absorbable antibiotic beads (CSAAB) in the prevention of surgical site infections (SSIs) for complex wound closures. Patient records from the University of New Mexico Hospital (UNMH; Albuquerque, NM) and Dartmouth-Hitchcock Medical Center (DHMC; Lebanon, NH) were retrospectively analyzed from 2...
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Dispersion Risk Associated With Surgical Debridement Devices.
CONCLUSIONS: Both instruments can be used safely in the proper conditions, but the surgeon needs to be aware of the limitations and risks of spray dispersion. PMID: 29091044 [PubMed - in process] (Source: Wounds)
Source: Wounds - November 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Effects of Keratinocytes Differentiated from Embryonic and Adipogenic Stem Cells on Wound Healing in a Diabetic Mouse Model.
CONCLUSIONS: Keratinocytes derived from ESCs accelerated wound healing in mice with diabetes mellitus. The beneficial effects were evident both histomorphologically and immunohistochemically. Although keratinocytes derived from ADSCs are readily available, such cells did not accelerate wound healing. PMID: 28976339 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - October 5, 2017 Category: General Medicine Tags: Wounds Source Type: research

Use of Tigecycline for Diabetic Foot Infections.
Authors: Arda B, Uysal S, Taşbakan M, Şimşir IY, Öztürk M, Ertam İ, Uysal A, Ulusoy S Abstract OBJECTIVE: The aim of this study is to evaluate tigecycline for diabetic foot infections (DFIs). MATERIALS AND METHODS: In this prospective observational study, the investigators included patients who had consultation with the Diabetic Foot Council of Ege University Faculty of Medicine (Izmir, Turkey) between March 2013 and July 2015 and who used tigecycline during their treatment. Treatment success was assessed by design-specific criteria for each evaluation. RESULTS: The study included 105 cases. O...
Source: Wounds - October 5, 2017 Category: General Medicine Tags: Wounds Source Type: research

Preliminary Results of a Topically Applied Bacteria-specific Antibiotic Gel to Improve Wound Healing.
CONCLUSIONS: Although a minor improvement of weekly healing rate was seen for a subset of the wounds, the overall wound closure rate was low. PMID: 28976341 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - October 5, 2017 Category: General Medicine Tags: Wounds Source Type: research

Topical Growth Hormone Accelerates Wound Healing in Mice.
CONCLUSIONS: The GH accelerates the closure of skin wounds by resolving the in- ammatory phase faster, accelerating reepithelialization and collagen deposition, and stimulating angiogenesis. PMID: 28976342 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - October 5, 2017 Category: General Medicine Tags: Wounds Source Type: research

A Novel Topical Wound Therapy Delivery System.
CONCLUSIONS: This delivery system dressing is an effective and safe treatment option for wounds. Advantages include reduced potential of systemic side effects, flexibility in what can be delivered, constant rate of medication delivery, and convenience. PMID: 28933696 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 23, 2017 Category: General Medicine Tags: Wounds Source Type: research

Enhanced Skin Regeneration Using a Novel Amniotic-derived Tissue Graft.
CONCLUSIONS: In sum, this study builds on the amassing literature supporting amniotic tissues for wound repair and demonstrates the importance of tissue processing on the quality of wound healing. PMID: 28933697 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 23, 2017 Category: General Medicine Tags: Wounds Source Type: research

Evidence Corner: Total Hip or Knee Arthroplasty: Improving Infection Risk.
Authors: Bolton L PMID: 28933698 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 23, 2017 Category: General Medicine Tags: Wounds Source Type: research

Pyoderma Gangrenosum: An Uncommon Case Report and Review of the Literature.
CONCLUSION: Although PG is rare, clinicians should suspect it in the presence of purplish wound edges with a necrotic center. Surgical debridement, while necessary in other ulcers, can worsen the condition and should only be applied to self-detachable necrotic plaques. PMID: 28933699 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 23, 2017 Category: General Medicine Tags: Wounds Source Type: research

Identification of Genes Differentially Expressed Between Midgestational and Postnatal Mouse Skin Through Suppression Subtractive Hybridization.
CONCLUSION: Through SSH, 20 differentially expressed genes in the skin of midgestational and postnatal mice were identified. Two novel genes were identified that were uniquely expressed in the midgestational mouse skin. The authors suggest these genes might be involved in the scarless wound healing process. PMID: 28902613 [PubMed] (Source: Wounds)
Source: Wounds - September 15, 2017 Category: General Medicine Tags: Wounds Source Type: research

Traction-assisted Internal Negative Pressure Wound Therapy With Bridging Retention Sutures to Facilitate Staged Closure of High-risk Wounds Under Tension.
CONCLUSION: Traction-assisted internal NPWT provides a safe and effective alternative to reduce wound burden and facilitate definitive closure in cases where delayed reconstruction of high-tension wounds is planned. PMID: 28873059 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - September 7, 2017 Category: General Medicine Tags: Wounds Source Type: research

A Retrospective Crossover Study of the Use of Aseptically Processed Placental Membrane in the Treatment of Chronic Diabetic Foot Ulcers.
CONCLUSION: The results of this crossover study support the conclusions of the original RCT, which determined that aseptically processed dHACA is an effective means to treat recalcitrant DFUs. Further studies, including comparative clinical trials, may offer additional information on this unique aseptically processed graft in the healing of indolent wounds. PMID: 28873060 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - September 7, 2017 Category: General Medicine Tags: Wounds Source Type: research

Clostridial Collagenase for the Management of Diabetic Foot Ulcers: Results of Four Randomized Controlled Trials.
CONCLUSIONS: Active CCO therapy was associated with a nonstatistically greater reduction in wound size than any of the passive or mechanical SC modalities at end of treatment. This was statistically significant when used in conjunction with sharp debridement and for slow healing ulcers, larger sized wounds, or plantar surface wounds. PMID: 28862974 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

G Protein-coupled Receptors and Proopiomelanocortin Expression After Light Emitting Diode Irradiation in Diabetic Wound Healing.
CONCLUSIONS: These lights activate the expression of GPR class A gene, which receives photons and transfers this signal to other downstream pathways inside the cell, specifically to the POMC gene, which will recover the wound-healing process to the normal stage. PMID: 28862975 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Sarcoidosis and Wound Healing After Cellulitis of the Lower Limb: Is Methotrexate Responsible for Skin Graft Failure?
Authors: Gaucher S, Nicolas C, Piveteau O, Philippe HJ, Blanche P Abstract The authors report the case of a 53-year-old man with diffuse cutaneous and mediastinal pulmonary sarcoidosis and well-controlled steroid-induced diabetes. He was hospitalized for cellulitis of his left leg. His standard treatment for sarcoidosis consisted of prednisone and methotrexate. Prednisone was stopped at his admission. He received antibiotics for 4 weeks to treat the cellulitis. In parallel, the leg wound was treated with daily silver sulfadiazine applications until necrosis removal, then by skin autografting. Four successive proced...
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Healing Rate of Chronic and Subacute Lower Extremity Ulcers Treated With Contact Ultrasound Followed by Noncontact Ultrasound Therapy: The VIP Ultrasound Protocol.
CONCLUSIONS: Both groups benefited from the VIP Protocol, which promoted wound closure or wound bed preparation for graft. The results seem to favor an earlier start of the protocol for best outcomes and indicate that contact and noncontact ultrasound therapies are not exclusionary but rather complementary. PMID: 28862977 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Editorial Message: Sometimes It Just Has to Be Done!
Authors: Treadwell T PMID: 28862978 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Negative Pressure Wound Therapy for a Giant Wound Secondary to Malignancy-induced Necrotizing Fasciitis: Case Report and Review of the Literature.
CONCLUSIONS: Rapid diagnosis of NF is critical to guide surgical management and administration of antibiotics. It is important to be mindful of the origin of certain necrotizing infections, and clinicians should have a greater index of suspicion for NF when assessing skin infections in unwell patients with concomitant bowel perforation secondary to gastrointestinal malignancy. PMID: 28862979 [PubMed - in process] (Source: Wounds)
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Management of Chronic Wounds: Diagnosis, Preparation, Treatment, and Follow-up.
Authors: Gupta S, Andersen C, Black J, de Leon J, Fife C, Lantis Ii JC, Niezgoda J, Snyder R, Sumpio B, Tettelbach W, Treadwell T, Weir D, Silverman RP Abstract Management of chronic wounds remains challenging in terms of prevalence and complexity. Considerable progress has been made in understanding the science of wound healing during the past decade, sparking volumes of publications and the development of hundreds of dressing and therapy options. There is a need for a simpli ed overview of evidence-based criteria to assist in the accurate diagnosis and appropriate management of chronic wounds in all care settings...
Source: Wounds - September 3, 2017 Category: General Medicine Tags: Wounds Source Type: research

Negative Pressure Wound Therapy for Patients With Complex Abdominal Wounds.
CONCLUSIONS: By providing suf cient drainage, NPWT effectively removed wound fluid and infectious material. The reduced edema helped lower intra-abdominal pressure, reduce the risk of abdominal compartment syndrome and infection, and improve patient prognosis. PMID: 28759427 [PubMed - in process] (Source: Wounds)
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Negative Pressure Wound Therapy for Patients With Complex Abdominal Wounds.
CONCLUSION: On the basis of this study, the authors determined that axonge might have potential for use in wound healing. PMID: 28759428 [PubMed - in process] (Source: Wounds)
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Serial Surgical Debridement of Common Pressure Injuries in the Nursing Home Setting: Outcomes and Findings.
CONCLUSION: Traditional bedside debridement provides excellent results in reducing the square surface area for a majority of wounds. Whether used alone or as an adjunct to any treatment plan, the use of surgical sharp equipment aids in achieving good wound healing and advancing the rate of wound closure. Although wound healing requires many components, sharp debridement can effectively remove devitalized tissue and is a proven significant component to advancing wound closure. PMID: 28759429 [PubMed - in process] (Source: Wounds)
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Squamous Cell Carcinoma Arising in a Chronic, Nonhealing Diabetic Foot Ulcer.
CONCLUSION: Clinicians should consider a diagnosis of SCC in any chronic, nonhealing DFU. Early surgical resection of a chronic, nonhealing DFU may prevent development of SCC in an ulcer. PMID: 28759430 [PubMed - in process] (Source: Wounds)
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Venous Ulcers Treated With a Hyaluronic Acid Extracellular Matrix and Compression Therapy: Interim Analysis of a Randomized Controlled Trial.
CONCLUSION: Clinicians should consider a diagnosis of SCC in any chronic, nonhealing DFU. Early surgical resection of a chronic, nonhealing DFU may prevent development of SCC in an ulcer. PMID: 28759431 [PubMed - in process] (Source: Wounds)
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Previous Atorvastatin Treatment and Risk of Diabetic Foot Infection in Adult Patients: A Case-control Study.
CONCLUSION: Prior therapy with atorvastatin considerably reduces the onset of DFIs. In addition to other effects, statins may be useful in preventing DFIs. PMID: 28762948 [PubMed - as supplied by publisher] (Source: Wounds)
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Laser Doppler Flowmetry and Transcutaneous Oximetry in Chronic Skin Ulcers: A Comparative Evaluation.
Authors: Raposio E, Bertozzi N, Moretti R, Grignaffini E, Grieco MP Abstract INTRODUCTION/OBJECTIVE: Laser Doppler Flowmetry (LDF) and transcutaneous oximetry (TcpO2) are established methods for investigating cutaneous perfusion. To date, no study previously performed has compared data obtained from these 2 methodologies in cases of chronic cutaneous ulcers. MATERIALS AND METHODS: Laser Doppler Flowmetry and TcpO2 were performed in 25 consecutive outpatients with chronic lower limb ulcers (group A, experimental; 9 women and 16 men; mean age 67 years [range, 52-81 years]) and 25 age- and sex-matched healthy cont...
Source: Wounds - August 2, 2017 Category: General Medicine Tags: Wounds Source Type: research

Negative Pressure Wound Therapy with Instillation: Review of Evidence and Recommendations.
Authors: Kim PJ, Attinger CE, Crist BD, Gabriel A, Galiano RD, Gupta S, Lantis Ii JC, Lavery L, Lipsky BA, Teot L Abstract Negative pressure wound therapy with instillation (NPWTi) and dwell time is an adjunctive treatment modality for selected complex wounds. Because of the greater amount of research now available, a multidisciplinary expert panel comprising the fields of podiatry, plastic and general surgery, burn treatment, infectious diseases, and orthopedics was convened on July 11, 2015, to produce a summary of the data and recommendations on the use of NPWTi. The panel members each reviewed available publish...
Source: Wounds - July 13, 2017 Category: General Medicine Tags: Wounds Source Type: research