Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Posterior perforator tibial artery flaps for soft tissue defects of limbs: a retrospective cohort study
CONCLUSION: Posterior perforator tibial artery flaps have the advantages of relatively simple technique, few damage, few complications and satisfying appearance. It is a good choice for soft tissue defects of limbs.PMID:38678501 | DOI:10.1007/s00068-024-02536-5 (Source: Hand Surgery)
Source: Hand Surgery - April 28, 2024 Category: Surgery Authors: Yiming Lu Bin Wang Tianliang Wang Jiaxiang Gu Hongjun Liu Source Type: research
A Simple and Reliable 2D-Shear Wave Elastography and UltraSound Coefficient Attenuation Parameter Technique in Chronic Liver Diseases
ConclusionA reliable diagnosis of advanced fibrosis and significant steatosis can be obtained with the median of three measurements in different liver portions using SS. The only non-reliable criterion is skin-to-liver distance ≥ 2.4 cm. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 28, 2024 Category: Gastroenterology Source Type: research
Response to Arbache et al. “Comment on “Vulvar lichen sclerosus and vitiligo: Overlap and clinical features”
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 28, 2024 Category: Dermatology Authors: Susie Suh, Alexa Kassels, Kathryn Hinchee Rodriquez, Jessica Shiu, Christina N. Kraus Source Type: research
Intravenous immunoglobulin (IVIg) ameliorates disease in a murine model of anti-laminin 332 mucous membrane pemphigoid
Intravenous immunoglobulin (IVIg) is used to treat mucous membrane pemphigoid (MMP), although its therapeutic effectivity is not sufficiently supported by randomized controlled clinical trials and its mode of action is only insufficiently understood. We have examined the effect of IVIg in a mouse model of anti-laminin 332 MMP and found that IVIg ameliorates both cutaneous and mucosal inflammatory lesions. Our investigation into the modes of action of IVIg in MMP indicated effective antiinflammatory mechanisms beyond the enhanced degradation of IgG mediated through inhibition of the neonatal Fc receptor. (Source: Journal of...
Source: Journal of Investigative Dermatology - April 28, 2024 Category: Dermatology Authors: Sripriya Murthy, Sabrina Patzelt, Axel K ünstner, Hauke Busch, Enno Schmidt, Christian D. Sadik Tags: Original Article Source Type: research
The relationship between religious affiliation and menopause symptoms and attitudes in United States women
Menopause a is key phase in female reproductive health and can result in bothersome symptoms. Natural menopause is defined as the permanent cessation of menstruation due to the loss of follicular activity in the ovaries, typically between the ages of 45 and 58 years [1]. Hot flashes and difficulty sleeping are commonly reported symptoms, and sexual dysfunction is a commonly reported diagnosis by women in this age group [2]. Hot flashes last an average of 7 years after natural menopause, but in some cases longer, and are characterized by a transient r ise in skin temperature and heart rate [2]. (Source: Maturitas)
Source: Maturitas - April 28, 2024 Category: Primary Care Authors: Annika Agarwal, Holly N. Thomas Tags: Original article Source Type: research
Posterior perforator tibial artery flaps for soft tissue defects of limbs: a retrospective cohort study
ConclusionPosterior perforator tibial artery flaps have the advantages of relatively simple technique, few damage, few complications and satisfying appearance. It is a good choice for soft tissue defects of limbs. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - April 28, 2024 Category: Emergency Medicine Source Type: research
The phenomenon of skin contraction in CO2 LASER surgical incisions using superpulse and continuous emission mode – preliminary study
This study suggests that the use of the Continuous mode of LASER emission, regardless of the power used, is associated with a higher level of final skin contraction.Trial registration number and date of registration for prospectively registered trialsProject approval registration number by the Research and Teaching Ethics Committee (CEIE),Faculty of Veterinary Medicine —University of Lisbon (FMV_ULisboa), Lisboa—Portugal, N/Refª 015/2022. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - April 28, 2024 Category: Laser Surgery Source Type: research
A Simple and Reliable 2D-Shear Wave Elastography and UltraSound Coefficient Attenuation Parameter Technique in Chronic Liver Diseases
ConclusionA reliable diagnosis of advanced fibrosis and significant steatosis can be obtained with the median of three measurements in different liver portions using SS. The only non-reliable criterion is skin-to-liver distance ≥ 2.4 cm. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 28, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1725: C-Reactive Protein Is a Potential Prognostic Marker in Patient with Advanced or Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multi-Center Retrospective Study
Conclusions: Our study provides real-world data showing that enfortumab vedotin prolonged survival in Asian patients similar to the EV-301 trial. Additionally, the C-reactive protein level might be considered a prognostic marker of enfortumab vedotin therapy in such patients. (Source: Cancers)
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Toshiharu Morikawa Taku Naiki Yosuke Sugiyama Aya Naiki-Ito Takashi Nagai Toshiki Etani Keitaro Iida Teruki Isobe Yusuke Noda Nobuhiko Shimizu Maria Aoki Masakazu Gonda Rika Banno Hiroki Kubota Ryosuke Ando Yukihiro Umemoto Noriyasu Kawai Takahiro Yasui Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1713: Ex Vivo Confocal Laser Scanning Microscopy in Rare Skin Diseases
This study highlights the potential of ex vivo confocal laser scanning microscopy as a promising adjunct to conventional dermatohistopathology for the early and precise identification of rare dermatological disorders. (Source: Cancers)
Source: Cancers - April 28, 2024 Category: Cancer & Oncology Authors: Luis Messner Maximilian Deu ßing Michaela Maurer Lisa Buttgereit Lara St ärr Lars E. French Daniela Hartmann Tags: Article Source Type: research
The crystallization properties of antifreeze GelMA hydrogel and its application in cryopreservation of tissue ‐engineered skin constructs
AbstractGelatin methacrylate (GelMA) hydrogels are expected to be ideal skin tissue engineering dressings for a wide range of clinical treatments. Herein, we report the preparation of GelMA or antifreeze GelMA hydrogel sheets with different GelMA concentrations, crosslinking times, and cryoprotectant (CPA) concentrations. The crystallization properties of GelMA or antifreeze GelMA hydrogel sheets were studied by cryomicroscopy and differential scanning calorimetry (DSC). It was found that the growth of ice crystals was slower when GelMA hydrogel concentration was more than 7%. The 10% DMSO-7% GelMA hydrogel sheets crosslin...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - April 27, 2024 Category: Materials Science Authors: Jia Tan,
Jiahui Li,
Xinli Zhou Tags: RESEARCH ARTICLE Source Type: research
Ethnobotanical Significance, Phytopharmacology, and Toxicological Profile of Limonia acidissima L. (Rutaceae): A Review
Comb Chem High Throughput Screen. 2024 Apr 25. doi: 10.2174/0113862073285538240417051928. Online ahead of print.ABSTRACTMedicinal plants play a crucial role in traditional medicine, where they are extensively employed by traditional physicians for treating a wide array of ailments. Limonia acidissima (Linn), commonly known as the Wood apple and belonging to the Rutaceae family, is widely cultivated in countries, such as Pakistan, India, and Sri Lanka. The various parts of Limonia acidissima, including its roots, leaves, fruits, stem, and even the whole plant, have been traditionally used in the treatment of numerous condit...
Source: Combinatorial Chemistry and High Throughput Screening - April 27, 2024 Category: Chemistry Authors: Satyajit Mohanty Ashok Pattnaik Source Type: research
The Effect of Preprocedural Low-Dose Ketamine for Pain and Anxiety in Patients during Thoracic Epidural Catheterization
Conclusions: A preprocedural LDK (0.15 mg/kg) can effectively prevent anxiety and pain experienced by patients during the TEC procedure. Administration of LDK may provide a more comfortable procedure process without causing ketamine-induced side effects (hemodynamic, respiratory, and psychological).PMID:38674325 | PMC:PMC11052147 | DOI:10.3390/medicina60040679 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Onur K üçük Esra Sar ı Musa Zengin G ülay Ülger Fatma Öztürk Yalçın Ramazan Baldemir Mehtap Tun ç Ali Alag öz Source Type: research
Exosomes and Signaling Nanovesicles from the Nanofiltration of Preconditioned Adipose Tissue with Skin-B < sup > ® < /sup > in Tissue Regeneration and Antiaging: A Clinical Study and Case Report
Conclusions: This retrospective clinical evaluation study allowed us to consider the results obtained with this method for the treatment of dermal wrinkles and facial tissue furrows as excellent. The method is safe and an innovative regenerative therapy as a powerful and viable alternative to skin regeneration therapies, antiaging therapies, and chronic inflammatory diseases because it lacks the inflammatory component produced by cellular debris and fibrous sprouts and because it can exclude the mesenchymal cellular component by reducing multiple inflammatory cytokine levels.PMID:38674316 | PMC:PMC11051917 | DOI:10.3390/me...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Fabiano Svolacchia Lorenzo Svolacchia Patrizia Falabella Carmen Scieuzo Rosanna Salvia Fabiana Giglio Alessia Catalano Carmela Saturnino Pierpaolo Di Lascio Giuseppe Guarro Giusy Carmen Imbriani Giuseppe Ferraro Federica Giuzio Source Type: research
