Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties
AbstractIn the field of bone regenerative medicine, injectable calcium phosphate cements (CPCs) are used for decades in clinics, as bone void fillers. Most often preformed polymers (e.g., hyaluronic acid, collagen, chitosan, cellulose ethers …) are introduced in the CPC formulation to make it injectable and improve its cohesion. Once the cement has hardened, the polymer is simply trapped in the CPC structure and no organic subnetwork is present. By contrast, in this work a CPC was combined with organic monomers that reticulated in sit u so that a continuous biocompatible 3D polymeric subnetwork was formed in the CPC...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 23, 2020 Category: Materials Science Authors: Silvia Stella Ramirez Caballero, Daniel Ferri ‐Angulo, Romain Debret, Fabien Granier, Sébastien Marie, François‐Xavier Lefèvre, Jean‐Michel Bouler, Christelle Despas, Jérôme Sohier, Bruno Bujoli Tags: ORIGINAL RESEARCH REPORT Source Type: research

Production of a novel poly( ɛ‐caprolactone)‐methylcellulose electrospun wound dressing by incorporating bioactive glass and Manuka honey
AbstractWound dressings produced by electrospinning exhibit a fibrous structure close to the one of the extracellular matrix of the skin. In this article, electrospinning was used to fabricate fiber mats based on the well ‐known biopolymers poly(ɛ‐caprolactone) (PCL) and methylcellulose (MC) using benign solvents. The blend fiber mats were cross‐linked using Manuka honey and additionally used as a biodegradable platform to deliver bioactive glass particles. It was hypothesized that a dual therapeutic effect ca n be achieved by combining Manuka honey and bioactive glass. Morphological and chemical examinations confir...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 20, 2020 Category: Materials Science Authors: Katharina Schuhladen, Swathi N. V. Raghu, Liliana Liverani, Zuzana Ne ščáková, Aldo R. Boccaccini Tags: ORIGINAL RESEARCH REPORT Source Type: research

Effects of rotor angle and time after centrifugation on the biological in vitro properties of platelet rich fibrin membranes
This study evaluated the impact of rotor angle and time of storage after centrifugation on the in vitro biological properties of platelet ‐rich fibrin (PRF) membranes. Blood samples (n = 9) were processed with a vertical fixed ‐angle (V) or a swing‐out horizontal (H) centrifuge, with 20–60 min of sample storage after centrifugation. Leukocytes, platelets, and red blood cells were counted, and fibrin architecture was observed by scanning electron microscopy (SEM). The release of FGF2, PDGFbb, VEGF, IL‐6, and IL‐ 1β was measured after incubation on culture media for 7–21 days. Cell co...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 20, 2020 Category: Materials Science Authors: Emanuelle Stellet Louren ço, Gutemberg Gomes Alves, Renata Lima Barbosa, Carolina Nascimento Spiegel, Rafael Coutinho Mello‐Machado, Sarah Al‐Maawi, Shahram Ghanaati, Carlos Fernando Almeida Barros Mourão Tags: ORIGINAL RESEARCH REPORT Source Type: research

Application of a novel thermo ‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release
In conclusion, the new thermo‐sensitive hydrogels with precisely regulated gelling time showed great significance and potential for drug delivery and neoadjuvant chemotherapy. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 17, 2020 Category: Materials Science Authors: Xiaoying Kong, Ruizhi Houzong, Jun Fu, Kai Shao, Lili Wang, Yongchao Ma, Jinsheng Shi Tags: ORIGINAL RESEARCH REPORT Source Type: research

Microneedle ‐based transdermal electrochemical biosensors based on Prussian blue‐gold nanohybrid modified screen‐printed electrodes
We report on the fabrication of a microneedle ‐based electrochemical biosensor for use in transdermal biosensing, which includes a screen‐printed electrode containing a Prussian blue‐gold nanohybrid as the working electrode. The Prussian blue gold nanohybrid is made from polyethylenime (PEI)‐ mediated simultaneous synthesis of Prussian blue (PBNP) and gold nanoparticles (AuNP), which forms a PBNP‐AuNP nanohybrid with a remarkable change in the Prussian blue character. PEI‐protected polycrystalline PBNPs can be synthesized in acidic media from the single precursor potassium ferricyanide [K3Fe(CN)6] at 60 °C....
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 16, 2020 Category: Materials Science Authors: Prem C. Pandey, Govind Pandey, Roger J. Narayan Tags: ORIGINAL RESEARCH REPORT Source Type: research

In vitro degradation profiles and in vivo biomaterial –tissue interactions of microwell array delivery devices
AbstractTo effectively apply microwell array cell delivery devices their biodegradation rate must be tailored towards their intended use and implantation location. Two microwell array devices with distinct degradation profiles, either suitable for the fabrication of retrievable systems in the case of slow degradation, or cell delivery systems capable of extensive remodeling using a fast degrading polymer, were compared in this study. Thin films of a poly(ethylene glycol) ‐poly(butylene terephthalate) (PEOT‐PBT) and a poly(ester urethane) were evaluated for their in vitro degradation profiles over 34 weeks incuba...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 16, 2020 Category: Materials Science Authors: Elahe Hadavi, Rick H.W. Vries, Alexandra M. Smink, Bart Haan, Jeroen Leijten, Leendert W. Schwab, Marcel H.B.J. Karperien, Paul Vos, Pieter J. Dijkstra, Aart A. Apeldoorn Tags: ORIGINAL RESEARCH REPORT Source Type: research

Mechanical performance and biocompatibility assessment of Zn ‐0.05wt%Mg‐(0.5, 1 wt%) Ag alloys
AbstractZn alloys are emerging as promising degradable biomedical materials due to their tailorable mechanical properties and moderate biodegradable rate, compared with conventional biodegradable metallic materials. Ag, as an effective antibacterial and reinforcing element, was incorporated into Zn ‐0.05Mg alloys. In the present work, the effects of the Ag addition on mechanical, cytotoxic, hemolytic, pyrogenic, histological behaviors of the animal were investigated. The compressive yielding strength is enhanced from 198 MPa for Zn‐0.05Mg alloy up to 224 and 234 MPa for Zn‐0.05Mg‐0 .5Ag and Zn‐0.05M...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 13, 2020 Category: Materials Science Authors: Chi Xiao, Yun Su, Xiaoming Zhu, Weiting Yu, Daping Cui, Xiaowei Wei, Xiuzhi Zhang, Junlei Li, Feng Wang, Yuping Ren, Gaowu Qin, Dewei Zhao Tags: ORIGINAL RESEARCH REPORT Source Type: research

Morphological and chemical analysis of surface interaction of irrigant ‐endosequence root repair material
In conclusion; nitrogen ‐rich compounds produced by chlorhexidine altered the surface morphology of the putty without crystallinity reduction. However, NaOCl reduced the organic fillers that affected its binding to phosphate ions. This reaction affects the chemical properties and perfection of root repair material. The c linicians should be aware of different irrigants to be used after repairing the perforation. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 8, 2020 Category: Materials Science Authors: Sawsan T. Abu Zeid, Ruaa A. Alamoudi, Khalid Merdad Tags: ORIGINAL RESEARCH REPORT Source Type: research

Long ‐term in vivo integrity and safety of 3D‐bioprinted cartilaginous constructs
AbstractLong ‐term stability and biological safety are crucial for translation of 3D‐bioprinting technology into clinical applications. Here, we addressed the long‐term safety and stability issues associated with 3D‐bioprinted constructs comprising a cellulose scaffold and human cells (chondrocytes and s tem cells) over a period of 10 months in nude mice. Our findings showed that increasing unconfined compression strength over time significantly improved the mechanical stability of the cell‐containing constructs relative to cell‐free scaffolds. Additionally, the cell‐free constructs exhibited a mean compressi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 6, 2020 Category: Materials Science Authors: Peter Apelgren, Matteo Amoroso, Karin S äljö, Anders Lindahl, Camilla Brantsing, Linnéa Stridh Orrhult, Kajsa Markstedt, Paul Gatenholm, Lars Kölby Tags: ORIGINAL RESEARCH REPORT Source Type: research

Substrate stiffness effects on SH ‐SY5Y: The dichotomy of morphology and neuronal behavior
AbstractLike many other cell types, neuroblastoma cells are also known to respond to mechanical cues in their microenvironment in vitro. They were shown to have mechanotransduction pathways, which result in enhanced neuronal morphology on stiff substrates. However, in previous studies, the differentiation process was monitored only by morphological parameters. Motivated by the lack of comprehensive studies that investigate the effects of mechanical cues on neuroblastoma differentiation, we used SH ‐SY5Y cells differentiated on polyacrylamide (PA) gels as a model. Cells differentiated on the surface of PA hydrogels with t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 5, 2020 Category: Materials Science Authors: Alp Ozgun, Fatma Zehra Erkoc ‐Biradlı, Osman Bulut, Bora Garipcan Tags: ORIGINAL RESEARCH REPORT Source Type: research

Comparative assessment of the efficiency of various decellularization agents for bone tissue engineering
In conclusion, SLES and, to a lesser degree, SDS 0.5% protocols could efficiently preserve ultrastructure and ECM constituents of decellularized bone tissue and can thus be suggested as nontoxic and safe protocols for bone regeneration. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 5, 2020 Category: Materials Science Authors: Asrin Emami, Tahereh Talaei ‐Khozani, Zahra Vojdani, Nehleh Zarei fard Tags: ORIGINAL RESEARCH REPORT Source Type: research

A convenient approach by using poly ‐(HEMA‐co‐NIPAM)/Cu2+ solution sol–gel transition for wound protection and healing
In this study, a temperature‐sensitive polymer of poly‐(HEMA‐co‐NIPAM) (PHN) was synthesized by free‐radical polymerization, in which the solution quickly underwent a sol–gel transition above 29°C, thus responding to a typical body temperature and facil itating wound sealing. PHN solution incorporated with copper ions (PHN‐Cu) not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis. The in vivo and in vitro experiments showed that the PHN‐Cu had a higher wound closure rate and demonstrated an ability to promote skin tissue angiogene...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 5, 2020 Category: Materials Science Authors: Yansong Wang, Xin Chu, Yu Sun, Peng Teng, Tianzhi Xia, Yisheng Chen Tags: ORIGINAL RESEARCH REPORT Source Type: research

Engineering HepG2 spheroids with injectable fiber fragments as predictable models for drug metabolism and tumor infiltration
AbstractIn vitro cell and tissue models are playing essential roles in the identification of active pharmaceutical ingredients. Though HepG2 cells have attractive profiles over primary hepatocytes in the availability and viability retention, the expression of metabolizing enzymes is quite low. In the current study, three ‐dimensional (3D) HepG2 spheroids with smaller sizes of 150 μm (3Ds) and bigger sizes of 300 μm (3Db) are engineered using injectable fiber fragments as the substrate. In contrast to two‐dimensional (2D) culture, the enzyme activities for drug metabolisms are restored in 3Ds and the...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 5, 2020 Category: Materials Science Authors: Jiaojun Wei, Dongmei Lei, Maohua Chen, Pan Ran, Xiaohong Li Tags: ORIGINAL RESEARCH REPORT Source Type: research

Foam ‐in‐vein: A review of rheological properties and characterization methods for optimization of sclerosing foams
AbstractVaricose veins are chronic venous defects that affect>20% of the population in developed countries. Among potential treatments, sclerotherapy is one of the most commonly used. It involves endovenous injection of a surfactant solution (or foam) in varicose veins, inducing damage to the endothelial layer and subsequent vessel sclerosis. Treatments have proven to be effective in the short ‐term, however recurrence is reported at rates of up to 64% 5‐year post‐treatment. Thus, once diagnosed with varicosities there is a high probability of a permanently reduced quality of life. Recently, foam sclerotherapy has...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 4, 2020 Category: Materials Science Authors: Alireza Meghdadi, Stephen A. Jones, Venisha A. Patel, Andrew L. Lewis, Timothy M. Millar, Dario Carugo Tags: REVIEW ARTICLE Source Type: research

Antimicrobial efficacy of platinum ‐doped silver nanoparticles
AbstractSilver nanoparticles (AgNPs) have been proposed to combat oral infection due to their efficient ionic silver (Ag+) release. However, concentrations required for antimicrobial efficacy may not be therapeutically viable. In this work, platinum ‐doped silver nanoparticles (Pt‐AgNPs) were explored to evaluate their potential for enhanced Ag+ release, which could lead to enhanced antimicrobial efficacy againstS.aureus,P.aeruginosa, andE.coli. AgNPs doped with 0.5, 1, and 2 mol% platinum (Pt0.5‐AgNPs, Pt1‐AgNPs, and Pt2‐AgNPs) were synthesized by a chemical reduction method. Transmission electron microscopy rev...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 3, 2020 Category: Materials Science Authors: Kan Wongkamhaeng, Junnan Wang, Jeffrey A. Banas, Deborah V. Dawson, Julie A. Holloway, Amanda J. Haes, Isabelle Denry Tags: ORIGINAL RESEARCH REPORT Source Type: research

Effectiveness of strontium ‐doped brushite, bovine‐derived hydroxyapatite and synthetic hydroxyapatite in rabbit sinus augmentation with simultaneous implant installation
In this study, strontium ‐doped brushite (Sr‐DCPD), a new bone substitute, together with bovine‐derived hydroxyapatite (bHA) and synthetic hydroxyapatite (sHA) was used in rabbit maxillary SA with simultaneous implant installation. The sinus space‐keeping capacity, resorption rate, osteoconductivity, and mechanical properties of regenerated bone, were evaluated by micro‐computed tomography (CT), histological analysis, and mechanical testing. Sr‐DCPD exhibited the best osteoconductivity and new bone formation (
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 3, 2020 Category: Materials Science Authors: Da ‐Zhuang Lu, Yan‐Bo Zhang, Wei Dong, Wen‐Juan Bi, Xiao‐Jie Feng, Li‐Ming Wen, Hong Sun, Hui Chen, Lu‐Yang Zang, Meng‐Chun Qi Tags: ORIGINAL RESEARCH REPORT Source Type: research

Microstructural evolution and corrosion behavior of a laser surface modified cast Co –Cr–Mo–C alloy
AbstractA Co –Cr–Mo–C biomedical alloy was processed by investment casting, and its surface was modified using pulsed laser melting. The modified surface underwent rapid solidification, and the exhibited microstructure as well as its corrosion properties were investigated. It was found that the laser surfa ce modified (LSM) Co–Cr–Mo–C alloy possesses enhanced corrosion resistance when compared with the same alloy in the as‐cast condition. Microstructural determinations indicated that the LSM Co–Cr–Mo–C alloy exhibited a lack significant solute segregation and a predom...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 3, 2020 Category: Materials Science Authors: Hamid ‐Reza Erfanian‐Nazif‐Toosi, Mario Rodriguez, Hugo F. López Tags: ORIGINAL RESEARCH REPORT Source Type: research

Development of NSAID ‐loaded nano‐composite scaffolds for skin tissue engineering applications
AbstractScar free healing together with pain management is one of the major considerations in full thickness wound healing. Extensive wounds take longer to heal without any clinical intervention and, hence, need natural or artificial extracellular matrix support for quick skin regeneration. To address these issues, medicated 3D porous biomimetic scaffolds were developed with a unique combination of biopolymers, that is, chitosan, sodium alginate, and elastin, supplemented with a non ‐steroidal anti‐inflammatory drug (NSAID). Scaffolds were physically characterized by scanning electron microscopy (SEM), Fourier transfor...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 3, 2020 Category: Materials Science Authors: Mubashra Zehra, Azra Mehmood, Muhammad Yar, Lubna Shahzadi, Sheikh Riazuddin Tags: ORIGINAL RESEARCH REPORT Source Type: research

In vitro and in vivo study on the osseointegration of BCP ‐coated versus uncoated nondegradable thermoplastic polyurethane focal knee resurfacing implants
AbstractFocal knee resurfacing implants (FKRIs) are intended to treat cartilage defects in middle ‐aged patients. Most FKRIs are metal‐based, which hampers follow‐up of the joint using magnetic resonance imaging and potentially leads to damage of the opposing cartilage. The purpose of this study was to develop a nondegradable thermoplastic polyurethane (TPU) FKRI and investigate its osseoi ntegration. Different surface roughness modifications and biphasic calcium phosphate (BCP) coating densities were first tested in vitro on TPU discs. The in vivo osseointegration of BCP‐coated TPU implants was subsequently compar...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 2, 2020 Category: Materials Science Authors: Ralph M. Jeuken, Alex K. Roth, Marloes J.M. Peters, Tim J.M. Welting, Lodewijk W. Rhijn, Jac Koenen, Ruud J.R.W. Peters, Jens C. Thies, Pieter J. Emans Tags: ORIGINAL RESEARCH REPORT Source Type: research

Issue Information
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 108, Issue 6, Page 2379-2385, August 2020. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - July 1, 2020 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Tooth sealing formulation with bacteria ‐killing surface and on‐demand ion release/recharge inhibits early childhood caries key pathogens
AbstractHerein, we investigated a biointeractive tooth sealing material consisted of dimethylaminohexadecyl methacrylate (DMAHDM) and amorphous calcium phosphate nanoparticles (NACPs) to address the above issues simultaneously. Of note, 5% DMAHDM was incorporated into the resin blend, and 20% NACP was added to inorganic filler content of dental formulations intended as dental sealants. The sealing materials were used to seal human extracted teeth. The sealed teeth were subjected to an early childhood caries (ECC) key pathogen (Candida albicans andStreptococcus mutans) biofilm model using a dynamic caries tooth model (CDC r...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 29, 2020 Category: Materials Science Authors: Maria Salem Ibrahim, Abdulrahman A. Balhaddad, Isadora M. Garcia, Eman Hefni, Fabricio M. Collares, Frederico C. Martinho, Michael D. Weir, Hockin H. K. Xu, Mary Anne S. Melo Tags: ORIGINAL RESEARCH REPORT Source Type: research

Acellular matrix hydrogel for repair of the temporomandibular joint disc
AbstractApplication of tissue ‐derived extracellular matrix (ECM) biomaterials in the repair of the temporomandibular joint (TMJ) disc is a promising approach for the treatment of disc abrasion and perforation, particularly for the young patient population. Although decellularized ECM (dECM) scaffolds preserve tissue‐specifi c structures as well as biological and biomechanical properties, they require surgical implantation. To address this issue, we prepared porcine TMJ discs into decellularized ECM with serial detergent and enzyme treatments, and the TMJ disc‐derived ECM was then processed into hydrogels via pepsin ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 29, 2020 Category: Materials Science Authors: Jiadi Liang, Ping Yi, Xiaojin Wang, Futing Huang, Xianghong Luan, Zuodong Zhao, Chang Liu Tags: ORIGINAL RESEARCH REPORT Source Type: research

A comparative study on the physicochemical characteristics of nanoparticles released in vivo from CoCrMo tapers and cement –stem interfaces of total hip replacements
AbstractThe good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions, or cement –stem interfaces can, therefore, have different chemical and mo...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 28, 2020 Category: Materials Science Authors: Alina M. Crainic, Mauro Callisti, Arjen Veelen, Agnes Michalik, James A. Milton, Martin R. Palmer, Richard B. Cook Tags: ORIGINAL RESEARCH REPORT Source Type: research

Phenylboronic acid ‐functionalized F127‐oligochitosan conjugate micelles for doxorubicin encapsulation
AbstractDoxorubicin shows good anticancer activity, but poor pharmacokinetic property and high organ toxicity restrict its clinical application. The synthesized phenylboronic acid ‐modified F127‐chitosan conjugate was used to prepare doxorubicin‐loaded micelles through dialysis method. The physicochemical properties of the doxorubicin‐loaded micelles were characterized. These micelles were further evaluated for in vitro release/cytotoxicity, in vivo activity/biosafety , and pharmacokinetic studies. in vitro release experiment demonstrated that the release of doxorubicin from drug‐loaded micelles was pH‐dependen...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 24, 2020 Category: Materials Science Authors: Runliang Feng, Wanqiu Wang, Li Zhu, Hongmei Xu, Shiyu Chen, Zhimei Song Tags: ORIGINAL RESEARCH REPORT Source Type: research

Handling and performance characteristics of a new small caliber radiopaque embolic microsphere
AbstractThe in vitro and in vivo handling and performance characteristics of a small caliber radiopaque embolic microsphere, 40 –90 μm DC Bead LUMI™ (LUMI40‐90), were studied. Microsphere drug loading and elution and effects on size, suspension, and microcatheter delivery were evaluated using established in vitro methodologies. In vivo evaluations of vascular penetration (rabbit renal artery embolization), long‐ term biocompatibility and X‐ray imaging properties, pharmacokinetics and local tissue effects of both doxorubicin (Dox) and irinotecan (Iri) loaded microspheres (swine hepatic art...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 23, 2020 Category: Materials Science Authors: Andrew L. Lewis, Marcus Caine, Pedro Garcia, Koorosh Ashrafi, Yiqing Tang, Lorcan Hinchcliffe, Wei Guo, Zainab Bascal, Hugh Kilpatrick, Sean L. Willis Tags: ORIGINAL RESEARCH REPORT Source Type: research

Fracture toughness of zirconia with a nanometer size notch fabricated using focused ion beam milling
This study was to investigate an alternative method to produce nanometer‐sized notches, which are less than the average grain size of 3Y‐TZP, during the preparation of single‐edge V‐notched beam specimens and report the resulting fracture toughness valu e.MethodsWe present a method using focused ion beam (FIB) milling to fabricate nanometer ‐sized notches in 3Y‐TZP. The notch tip is
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 20, 2020 Category: Materials Science Authors: Yifeng Liao, Max Gruber, Henry Lukic, Si Chen, Spiro Megremis Tags: ORIGINAL RESEARCH REPORT Source Type: research

New cross ‐linkable poly[bis(octafluoropentoxy) phosphazene] biomaterials: Synthesis, surface characterization, bacterial adhesion, and plasma coagulation responses
In this study, we synthesized cross‐linkable OFPs (X‐OFPs) with the different degrees of cross‐l inking in an effort to improve the mechanical properties. The results showed that the surface chemistry and surface topography of X‐OFPs do not change significantly, but the surface mechanical stiffness increased after cross‐linking. Atomic force microscopic phase images showed that the polymer phase separation structures changed due to cross‐linking. Experiments with three bacterial strains:Staphylococcal epidermidis, Staphylococcal aureus, andPseudomonas aeruginosa showed that bacterial adhesion was significantly ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 18, 2020 Category: Materials Science Authors: Li ‐Chong Xu, Chen Chen, Jieru Zhu, Meixian Tang, Andy Chen, Harry R. Allcock, Christopher A. Siedlecki Tags: ORIGINAL RESEARCH REPORT Source Type: research

Calcium sulfate ‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation
We report here on novel modified g lass polyalkenoate cements (mGPCs) containing 1, 5 and 15 wt% calcium sulfate (CaSO4) and how the modified cements' properties compare to those of PMMA used in rTKA. CaSO4 is incorporated into the mGPC to improve both osteoconductivity and bioresorbability. The results confirm that the incorporation of CaSO4 into mGPCs decreases the setting time and increases release of therapeutic ions such as Ca2+ and Zn2+ over 30  days of maturation in deionized (DI) water. Moreover, the compressive strength for 5 and 15 wt% CaSO4 addition increased to over 30  MPa after 30&...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 17, 2020 Category: Materials Science Authors: Leyla Hasandoost, Adel Alhalawani, Omar Rodriguez, Alireza Rahimnejad Yazdi, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler Tags: ORIGINAL RESEARCH REPORT Source Type: research

A metallic biomaterial tribocorrosion model linking fretting mechanics, currents, and potentials: Model development and experimental comparison
This study presents a theoretical approach to predict currents and voltages over time utilizing the concepts of heredity integrals, area‐dependent surface impedance, contact mechanics and the hig h field physics of oxide repassivation. Two heredity integrals are presented relating, first, the sliding mechanics and oxide film repassivation physics to the current, and second, relating the electrode potential to the current using impedance concepts. Current–potential–time responses to contr olled fretting conditions were measured across a fretting frequency from 0.2 to 10 Hz and compared to theoretical results. ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 14, 2020 Category: Materials Science Authors: Jeremy L. Gilbert, Dongkai Zhu Tags: ORIGINAL RESEARCH REPORT Source Type: research

Concentration ‐dependent effects of latex F1‐protein fraction incorporated into deproteinized bovine bone and biphasic calcium phosphate on the repair of critical‐size bone defects
In this study, we investigated the concentration ‐dependent effects of F1 (0.01%, 0.025%, 0.05%, and 0.1%) incorporated into deproteinized bovine bone (DBB) and porous biphasic calcium phosphate (pBCP), on the repair of rat calvarial critical‐size bone defects (CSBD). The defects were analyzed by 3D‐microtomography and 2D‐histomorphometry at 12 weeks postsurgery. The binding efficiency of F1 to pBCP (96.3 ± 1.4%) was higher than that to DBB (67.7 ± 3.3%). In vivo analysis showed a higher bone volume (BV) gain in all defects treated with DBB (except in 0.1% of F1) and pBCP (except ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 14, 2020 Category: Materials Science Authors: Suelen Paini, Ana Carolina Cestari Bighetti, Tania Mary Cestari, Ricardo Vinicius Nunes Arantes, Paula Sanches Santos, Ever Elias Mena ‐Laura, Gustavo Pompermaier Garlet, Rumio Taga, Gerson Francisco Assis Tags: ORIGINAL RESEARCH REPORT Source Type: research

Structural phase formation and in vitro bioactivity evaluations of strontium phosphosilicate for orthopedic applications
AbstractStructural features of apatites make them one of the most promising candidates for bone tissue regenerative applications. The unique structure and availability of mobile Metal ion as well as other components help interaction with biological fluids and can promote as well as stimulate bone regeneration with correct components. The present study focusses on Strontium phosphosilicate, an apatite analogue to Calcium phosphate ‐based HAP only loaded with better composition replacing Calcium with stimulatory Strontium and co‐existent Silicate alongside phosphate both known to stimulate osteogenesis. Bulk particles we...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 12, 2020 Category: Materials Science Authors: Chetan, Uthirapathy Vijayalakshmi Tags: ORIGINAL RESEARCH REPORT Source Type: research

Development of novel surface coating composed of MDPB and MPC with dual functionality of antibacterial activity and protein repellency
AbstractResin ‐based reconstructive/restorative materials with antibacterial effects are potentially useful for preventing dental and oral diseases. To this end, the immobilization of an antibacterial component on the surface of a resin by incorporating polymerizable bactericide such as a quaternary ammonium co mpound‐monomer 12‐methacryloyloxydodecylpyridinium bromide (MDPB) is an effective technique. However, the effectiveness of immobilized bactericide is reduced by salivary protein coverage. We address this issue by utilizing 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymer, which exhibits protein repelle...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 10, 2020 Category: Materials Science Authors: Pasiree Thongthai, Haruaki Kitagawa, Ranna Kitagawa, Nanako Hirose, Susita Noree, Yasuhiko Iwasaki, Satoshi Imazato Tags: ORIGINAL RESEARCH REPORT Source Type: research

Decellularized muscle ‐derived hydrogels support in vitro cardiac microtissue fabrication
In conclusion, it might be imperative to use decellularized tissue of muscle origins in combination with naturally derived vascular tissues to generate in vitro vascularized human cardiac microtissues. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 10, 2020 Category: Materials Science Authors: Sarah Rajabi, Nasser Aghdami, Fahimeh Varzideh, Melika Parchehbaf ‐Kashani, Fatemeh Nobakht Lahrood Tags: ORIGINAL RESEARCH REPORT Source Type: research

Tuftelin ‐derived peptide facilitates remineralization of initial enamel caries in vitro
In this study, we designed a tuftelin ‐derived peptide (TDP) and tested its effects on hydroxyapatite crystallization and remineralization of initial enamel carious lesions in vitro. Using circular dichroism spectroscopy, we found that TDP contained 36.1% β‐sheets and β‐turns, which could be influenced by calcium ions. We verifi ed the ability of TDP to crystallize hydroxyapatite using transmission electron microscopy and its ability to bind to the enamel surface and hydroxyapatite using confocal laser scanning microscopy and Langmuir adsorption isotherms (K = 881.56,N = 1.41  × 10&minus...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 10, 2020 Category: Materials Science Authors: Longjiang Ding, Sili Han, Xiu Peng, Kun Wang, Sainan Zheng, Haoran Li, Yumei Niu, Wei Li, Linglin Zhang Tags: ORIGINAL RESEARCH REPORT Source Type: research

Retraction: Zhang, Y, Ou, Y, Guo, J, Huang, X. Ultrasound ‐triggered breast tumor sonodynamic therapy through hematoporphyrin monomethyl ether‐loaded liposome. J Biomed Mater Res. 2020; 108B: 948–957
Journal of Biomedical Materials Research Part B: Applied Biomaterials, EarlyView. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 7, 2020 Category: Materials Science Tags: Retraction Source Type: research

Poly ‐L‐lactide scaffolds with super pores obtained by freeze‐extraction method
AbstractA nonplanar polylactide scaffold to be used in tissue engineering was obtained by freeze ‐extraction method. Properties of the scaffold were modified by adding Eudragit® E100. The impact of the modification on morphology, porosity and pore size, mass absorbability, mechanical properties was determined. Scanning electron microscopy (SEM), hydrostatic weighing test, static compression test was used to this end. The chemical composition of the scaffold was defined based on infrared spectroscopy (FTIR) and energy‐dispersive X‐ray spectroscopy (EDX). Biocompatibility was confirmed by quantitative tests and mic...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 5, 2020 Category: Materials Science Authors: Monika Budnicka, Dorota Ko łbuk, Paweł Ruśkowski, Agnieszka Gadomska‐Gajadhur Tags: ORIGINAL RESEARCH REPORT Source Type: research

In vitro estimation of reduction in strength and wear resistance of UHMWPE for joint prostheses due to lipid ‐induced degradation
In this study, lipid‐induced degradation was simulated by SQ absorption and subsequent accelerated aging, and its influence on the strength and wear resistance of UHMWP E was investigated using wear, fatigue crack growth, and delamination testing. Lipid‐induced degradation was found to have little impact on fatigue crack growth rates and delamination resistance. These results were consistent with previous reports that lipid‐induced degradation is localized near the surface. However, we also found that lipid‐induced degradation increased the wear rate of both non‐crosslinked and crosslinked UHMWPE by a factor of 2...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 3, 2020 Category: Materials Science Authors: Hideyuki Sakoda, Yoshihiro Okamoto, Yuji Haishima Tags: ORIGINAL RESEARCH REPORT Source Type: research

Crosslinking of gum ‐based composite scaffolds for enhanced strength and stability: A comparative study between sodium trimetaphosphate and glutaraldehyde
In conclusion, STMP serves as a better crosslinker in comparison to GA and can be used in the fabrication of scaffolds for bone tissue engineering. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 3, 2020 Category: Materials Science Authors: Mugdha Makrand Joglekar, Devlina Ghosh, Dhivyaa Anandan, Puja Yatham, Rahul Dev Jayant, N. Arunai Nambiraj, Amit Kumar Jaiswal Tags: ORIGINAL RESEARCH REPORT Source Type: research

Alteration of structural and mechanical properties of the temporomandibular joint disc following elastase digestion
This study attempts to characterize the structural–functional contribution of elastin in the temporomandibular joint disc. Using elastase, we selectively perturbed the e lastin fiber network in porcine temporomandibular joint discs and investigated the structural, compositional, and mechanical regional changes through: (a) analysis of collagen and elastin fibers by immunolabeling and transmission electron microscopy; (b) quantitative analysis of collagen tortuosity, cell shape, and disc volume; (c) biochemical quantification of collagen, glycosaminoglycan and elastin content; and (d) cyclic compression test. Followin...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 1, 2020 Category: Materials Science Authors: Sepanta Fazaeli, Fereshteh Mirahmadi, Vincent Everts, Theodoor H. Smit, Jan H. Koolstra, Samaneh Ghazanfari Tags: ORIGINAL RESEARCH REPORT Source Type: research

Novel degradation flow ‐through chamber for in vitro biomaterial characterization
AbstractThe characterization of degradation of biodegradable materials for tissue regeneration is classically carried out in three steps: in vitro degradation analysis, in vitro cell culture, and in vivo animal experiments. Each step involves an increasing complexity and should serve a more sophisticated material selection, which serves as an orientation to clinical studies and the final application in patients. Recently, the usefulness of degradation analyses is being discussed. In this context, the aim of this work is to increase the importance of in vitro degradation analysis by using flowing media to move closer to the...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 30, 2020 Category: Materials Science Authors: Benjamin Kruppke, Jonas Wei ß, Sina Rößler, Christiane Heinemann, Thomas Hanke Tags: ORIGINAL RESEARCH REPORT Source Type: research

CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining
AbstractImplants like meshes for the reinforcement of tissues implement the formation of a persistent inflammation with an ambient fibrotic reaction. In the inflammatory infiltrate several distinct cell types have been identified, but CD68+ macrophages are supposed to be most important. To investigate the collaboration among the various cell types within the infiltrate we performed at explanted meshes from humans double fluorescence staining with CD68 as a constant marker and a variety of other antibodies as the second marker. The list of second markers includes lymphocytes (CD3, CD4, CD8, CD16, CD56, FoxP3, and CD11b) ste...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 30, 2020 Category: Materials Science Authors: Uwe Klinge, Axel Dievernich, Rene Tolba, Bernd Klosterhalfen, Luke Davies Tags: ORIGINAL RESEARCH REPORT Source Type: research

Physical and biological properties of blend ‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study
AbstractDual ‐pump electrospinning of antibacterial N‐decyl‐N, N‐dimethyl‐1‐decanaminium‐chloride (DDAC)‐loaded polycaprolactone (PCL) nanofibers, and chitosan (CS)/polyethylene‐oxide (PEO)‐based wound dressings with hydrophilic and hydrophobic properties to eliminate and absorb pathogenic ba cteria from wound surface besides antibacterial action and to support wound healing and accelerate its process. Physicochemical properties of the prepared nanofibrous mat as well as antibacterial, cytotoxicity, and cell compatibility were studied. The full‐thickness excisional wound healing proper ties up to 3&th...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 27, 2020 Category: Materials Science Authors: Mahdi Zafari, Milad Mansouri, Shadi Omidghaemi, Amid Yazdani, Samiramis Pourmotabed, Ali Hasanpour Dehkordi, Hamed Nosrati, Majid Validi, Esmaeel Sharifi Tags: ORIGINAL RESEARCH REPORT Source Type: research

Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care
This study addresses the in vitrobiologic effects of a clinically available dehydrated amniotic membrane allograft (DAMA). The broad mechanism of action results from DAMA's biologic composition that leads to stimulation of cell migration cell proliferation, and reduction of pro ‐inflammatory cytokines. Results show that DAMA possesses growth factors and cytokines such as EGF, FGF, PDGFs, VEGF, TGF‐β, IL‐8, and TIMPs 1 and 2. Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the re duction of pro‐inflammatory cytokines IL‐1...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 26, 2020 Category: Materials Science Authors: Marc C. Moore, Paul P. Bonvallet, Sita M. Damaraju, Heli N. Modi, Ankur Gandhi, Peter S. McFetridge Tags: ORIGINAL RESEARCH REPORT Source Type: research

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective
AbstractIn recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting ‐edge technology, including minimally invasive and organ‐preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bl eeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for eff...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 26, 2020 Category: Materials Science Authors: Margarida Pacheco, Alexandre A. Barros, Ivo M. Aroso, Riccardo Autorino, Est êvão Lima, Joana M. Silva, Rui L. Reis Tags: REVIEW ARTICLE Source Type: research

Microarray analysis reveals that lncRNA PWRN1 ‐209 promotes human bone marrow mesenchymal stem cell osteogenic differentiation on microtopography titanium surface in vitro
AbstractSandblasted, large ‐grit, and acid‐etched (SLA) titanium (Ti) with microtopography is currently one of the most widely used implant materials to accelerate osseointegration. Numerous long noncoding RNAs (lncRNAs) have been involved in bone remodeling, with their role in osseointegration, and the underlying mechani sms remain largely unclear. Here, microarrays of human bone marrow mesenchymal stem cells (hBMSCs) were used to identify differentially expressed lncRNAs during early cell differentiation stages (0–7 days) on SLA Ti and polished Ti surfaces. The function of lncRNAs in the osteogenic diffe...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 24, 2020 Category: Materials Science Authors: Mingyue Wang, Xiyuan Ge, Yan Zheng, Chenxi Wang, Yu Zhang, Ye Lin Tags: ORIGINAL RESEARCH REPORT Source Type: research

Detrusor bioengineering using a cell ‐enriched compressed collagen hydrogel
ConclusionCompressed collagen possesses an adequate regenerative potential to promote regeneration of bladder wall tissue in vivo. Seeded with a combination of pADSC and SMC this may well be the first step towards a functional bladder reconstruction especially in patients suffering of end ‐stage bladder diseases. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 18, 2020 Category: Materials Science Authors: Jakub Smolar, Daniele De Nardo, Ernst Reichmann, Rita Gobet, Daniel Eberli, Maya Horst Tags: ORIGINAL RESEARCH REPORT Source Type: research

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter
This study indicated that the Cu‐bearing chitosan coating could endow th e vascular implant interventional device anticoagulation and anti‐infection functions, which has excellent potential for clinical application. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 18, 2020 Category: Materials Science Authors: Lirong Wang, Deniz E. Eri şen, Ke Yang, Bingchun Zhang, Hongyu Guan, Shanshan Chen Tags: ORIGINAL RESEARCH REPORT Source Type: research

Comparison of the formation, adipogenic maturation, and retention of human adipose ‐derived stem cell spheroids in scaffold‐free culture techniques
AbstractWhile three ‐dimensional spheroids outperform traditional two‐dimensional monolayer culture for human adipose‐derived stem cells (hASCs), there is not a consensus on the most successful method for enhancing their adipogenic differentiation and minimizing the loss of physiologically relevant, fatty spheroi ds during culture. To this end, we compared three culture methods, namely, elastin‐like polypeptide‐polyethyleneimine (ELP‐PEI) coated surfaces, ultra‐low attachment static culture, and suspension culture for their ability to form and retain productive hASC spheroids. The ELP‐PEI coatings used the ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 12, 2020 Category: Materials Science Authors: Sarah J. Fitzgerald, Jared S. Cobb, Amol V. Janorkar Tags: ORIGINAL RESEARCH REPORT Source Type: research

Comparison of the electrochemical behavior of CoCrWNi, CoCrFeNiMo, and CoNiCrMo alloys
AbstractNumerous studies have examined the electrochemical behavior of Co ‐28Cr‐6Mo and Co‐35Ni‐20Cr‐10Mo in simulated physiological solutions. However, two other CoCr alloys—Co‐20Cr‐15W‐10Ni and Co‐20Cr‐16Fe‐15Ni‐7Mo—have received relatively little attention. In this work, cyclic potentiodynamic polarization and electrochemical impedance spect roscopy (EIS) were used to investigate the electrochemical behavior of as‐received and passivated CoCrWNi and CoCrFeNiMo in phosphate‐buffered saline. Comparison of the potentiodynamic results with those for as‐received and electropolished C...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 9, 2020 Category: Materials Science Authors: Bruce G. Pound Tags: ORIGINAL RESEARCH REPORT Source Type: research

High porous electrospun poly( ε‐caprolactone)/gelatin/MgO scaffolds preseeded with endometrial stem cells promote tissue regeneration in full‐thickness skin wounds: An in vivo study
AbstractIn the current study, electrospun poly( ε‐caprolactone)‐gelatin (PCL‐Gel) fibrous scaffolds containing magnesium oxide (MgO) particles and preseeded with human endometrial stem cells (hEnSCs) were developed to use as wound care material in skin tissue engineering applications. Electrospun fibers were fabricated using PCL‐Gel (1:1 [wt/wt]) with different concentrations of MgO particles (1, 2, and 4 wt%). The fibrous scaffolds were evaluated regarding their microstructure, mechanical properties, surface wettability, and in vitro and in vivo performances. The full‐thickness excisional wound model was...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - May 9, 2020 Category: Materials Science Authors: Shima Ababzadeh, Ali Farzin, Arash Goodarzi, Roya Karimi, Morteza Sagharjoghi Farahani, Mohsen Eslami Farsani, Kamelia Gharibzad, Maria Zahiri, Jafar Ai Tags: ORIGINAL RESEARCH REPORT Source Type: research