Journal of Biomedical Materials Research Part B: Applied Biomaterials This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Emulgel based on fish skin collagen ‐microalgae‐silver increased neovascularization and re‐epithelialization of full thickness burn in rats
AbstractDeep skin burn represents a global morbidity and mortality problem, and the limitation of topical treatment agents has motivated research to development new formulations capable of preventing infections and accelerating healing. The aim of this work was to develop and characterize an emulgel based on collagen (COL) and gelatin (GEL) extracted from fish skin associated withChlorella vulgaris extract (CE) and silver nitrate (AgNO3). COL and GEL were characterized by physicochemical and thermal analyses; and CE by electrophoresis and its antioxidant capacity. Three emulgels formulations were developed: COL (0.5%)  +...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 28, 2024 Category: Materials Science Authors: Francisco F ábio Pereira de Souza, Igor Iuco Castro‐Silva, Fábia Karine Andrade, Adriano Lincoln Albuquerque Mattos, Mirrael de Sousa Lopes, Wallady da Silva Barroso, Bartolomeu Warlene Silva de Souza, Men de Sá Moreira de Souza‐Filho, Andr Tags: RESEARCH ARTICLE Source Type: research

Albumin suppresses oxidation of Ti Nb alloy in the simulated inflammatory environment
This study aims to address the question of how albumin influences the corrosion resistance of TiNb alloy under simulated inflammation. Electrochemical and ion release tests have revealed that albumin significantly enhances corrosion resistance over both short (2 and 24  h) and long (2 weeks) exposure periods. Furthermore, post-immersion XPS and cross-section TEM analysis have demonstrated that prolonged exposure to an albumin-rich inflammatory solution results in the complete coverage of the TiNb surface by a protein layer. Moreover, TEM studies revealed that H2O2-induced oxidation and further formation of a defe...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 27, 2024 Category: Materials Science Authors: Agata Sotniczuk, Damian Kalita, Witold Chromi ński, Magdalena Matczuk, Marcin Pisarek, Halina Garbacz Tags: RESEARCH ARTICLE Source Type: research

Direct inkjet writing of polylactic acid/ β‐tricalcium phosphate composites for bone tissue regeneration: A proof‐of‐concept study
The objective of this study was to establish a basis for the development of direct inkjet writing (DIW)-based shape memory polymer-ceramic composites for bone tissue regeneration applications and to establish material behavior under thermomechanical loading. Polymer-ceramic (polylactic acid [PLA]/ β-tricalcium phosphate [β-TCP]) colloidal gels were prepared of different w/w ratios (90/10, 80/20, 70/30, 60/40, and 50/50) through polymer dissolution in acetone (15% w/v). Cytocompatibility was analyzed through Presto Blue assays. Rheological properties of the colloidal gels were measured to de termine shear-thinning capabil...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 24, 2024 Category: Materials Science Authors: Vasudev Vivekanand Nayak, Vijayavenkataraman Sanjairaj, Rakesh Kumar Behera, James E. Smay, Nikhil Gupta, Paulo G. Coelho, Lukasz Witek Tags: RESEARCH ARTICLE Source Type: research

Improving osseointegration and antimicrobial properties of titanium implants with black phosphorus nanosheets ‐hydroxyapatite composite coatings for vascularized bone regeneration
In this study, black phosphorus nanosheets (BPNSs) were doped into hydroxyapatite (HA) coatings using electrophoretic deposition. The coatings' surface morphology, roughness, water contact angle, photothermal properties, and antibacterial properties were investigated. The BP/HA coating exhibited a surface roughness of 59.1  nm, providing an ideal substrate for cell attachment and growth. The water contact angle on the BP/HA coating was measured to be approximately 8.55°, indicating its hydrophilic nature. The BPNSs demonstrated efficient photothermal conversion, with a temperature increase of 42.2°C under laser ir radi...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 23, 2024 Category: Materials Science Authors: Shilong Ma, Ruize Sun, Yuhui Wang, Yan Wei, Haofeng Xu, Xuanyu Liu, Ziwei Liang, Liqin Zhao, Yinchun Hu, Xiaojie Lian, Meiqing Guo, Di Huang Tags: RESEARCH ARTICLE Source Type: research

Photocurable extracellular matrix sealant for cessation of venous hemorrhage
AbstractHemorrhage is the second leading cause of death in patients under 46  years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often the first line of defense, but long-term care requires staples, hemostatic agents, or sealants that seal the vessel and restor e blood flow. Here, we compare a new photocurable extracellular matrix sealant (pcECM) with low, medium, and high crosslink density formulations to a commercially available fibrin-based sealant, TISSEEL®. pcECM has potential uses in surgical and remot...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 23, 2024 Category: Materials Science Authors: Luke E. Schepers, Brooke L. Martindale, Alycia G. Berman, Hannah L. Cebull, William Van Alstine, Sydney E. Hollingshead, Tyler Novak, Craig J. Goergen Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 19, 2024 Category: Materials Science Tags: ISSUE INFORMATION Source Type: research

Biosafety and chemical solubility studies of multiscale crystal ‐reinforced lithium disilicate glass‐ceramics
AbstractLithium disilicate (Li2Si2O5) glass-ceramics are currently a more widely used all-ceramic restorative material due to their good mechanical properties and excellent aesthetic properties. However, they have a series of problems such as high brittleness and low fracture toughness, which has become the main bottleneck restricting its development. Therefore, in order to compensate for these shortcomings, we propose to prepare a reinforced glass-ceramics with better mechanical properties and to test the biosafety and chemical solubility of the material. Li2Si2O5 whiskers were synthesized by a one-step hydrothermal metho...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 9, 2024 Category: Materials Science Authors: Tong Zhang, Jinrong Liu, Jin Qi, Lingxiang Sun, Xiaoming Liu, Jingyu Yan, Yanjie Zhang, Xiuping Wu, Bing Li Tags: RESEARCH ARTICLE Source Type: research

Association between blood markers and the progression of osseointegration in percutaneous prostheses patients —A pilot study
AbstractPatients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket-suspension systems. However, OI systems have been associated with superficial and deep-bone infections and implant loosening due, in part, to a failure of the osseointegration process. Although monitoring the osseointegration using circulating biomarkers has clinical relevance for understanding the progression of osseointegration with these devices, it has yet to be established. Ten patients were enrolled in this study. Blood ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 8, 2024 Category: Materials Science Authors: Andrew Miller, Sujee Jeyapalina, Jayant P. Agarwal, James Peter Beck Tags: RESEARCH ARTICLE Source Type: research

Injectable macroporous naturally ‐derived apatite bone cement as a potential trabecular bone substitute
In this study, we have formulated a novel apatite bone cements derived from natural sources (i.e. eggshell and fishbone) with improved qualities that is, porosity, resorbability, biological activity, and so forth. The naturally-derived apatite bone cement (i.e. FBDEAp) was prepared by mixing hydroxyapatite (synthesized from fishbone) and tricalcium phosphate (synthesized from eggshell) as a solid phase with a liquid phase (a dilute acidic blend of cement binding accelerator and biopolymers like gelatin and chitosan) with polysorbate (as liquid porogen) to get a desired bone cement paste. The prepared cement paste sets with...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 8, 2024 Category: Materials Science Authors: Vimal Kumar Dewangan, T. S. Sampath Kumar, Mukesh Doble, Viju Daniel Varghese Tags: RESEARCH ARTICLE Source Type: research

Evaluation of rabbit adipose derived stem cells fate in perfused multilayered silk fibroin composite scaffold for Osteochondral repair
In conclusion, applying flow perfusion on the prepared integrated trilayered SF-based scaffold can support osteogenic and chondrogenic differentiation for repairing osteochondral defects. (Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials)
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 5, 2024 Category: Materials Science Authors: Sara Zadegan, Bahman Vahidi, Jhamak Nourmohammadi, Asiyeh Shojaee, Nooshin Haghighipour Tags: RESEARCH ARTICLE Source Type: research

Development and optimization of kaempferol loaded ethosomes using Box –Behnken statistical design: In vitro and ex‐vivo assessments
AbstractKaempferol (KMP) belong to flavonoid class have developed in ethosomal formulation and were evaluated for their potential to treat diabetic foot ulcers. Even though ethosomes are highly deformable, they can pass through human skin intact. KMP ethosomes were formulated using the cold method and optimized by Box –Behnken design (BBD) (three-factor, three-level (33)). The formulation variables used for optimization are drug concentration of KMP, soylecithin content, and ethanol percentage. The optimized formulation was examined using transmission electronic microscopy (TEM), differential scanning calorimetry (DSC), ...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 4, 2024 Category: Materials Science Authors: Shraddha Singh Raghav, Bhavna Kumar, Neeraj Kumar Sethiya, Shilpa Pahwa Tags: RESEARCH ARTICLE Source Type: research

Zinc ‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine
Abstract6-Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblastic leukemia as an important agent in maintenance therapy. Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms capable of forming coordination compounds with metal ions, for example zinc. Therefore, in this work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions, and used it as a carrier for 6MP. Doped HAp has n...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - March 4, 2024 Category: Materials Science Authors: Marcel Jakubowski, Łukasz Majchrzycki, Aleksej Zarkov, Adam Voelkel, Mariusz Sandomierski Tags: RESEARCH ARTICLE Source Type: research

Development of guar gum reinforced calcium magnesium phosphate ‐based bone biocement
This study aims at developing a calcium magnesium phosphate-based bone biocement that combines a natural polymer and regenerative properties of bone bonding materials. The formulation of this biocement consists of oxidized guar gum, polydopamine, and calcium magnesium phosphate. The oxidized guar gum is easily soluble in water and has a slightly basic pH, unlike unmodified guar gum, thus allowing a homogenous paste to form in the alkaline environment of calcium magnesium phosphate. Three different oxidized degrees of guar gum were made, and the impact on the biocement properties was studied. The modified guar gum-reinforce...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 25, 2024 Category: Materials Science Authors: Vidul Goenka, Anupama Devi V. K., Ceera Manikandan, Amit Kumar Jaiswal Tags: RESEARCH ARTICLE Source Type: research

Studying the electrical, mechanical, and biological properties of BCZT –HA composites
AbstractThe piezoelectric properties of natural bone and their influence on bone growth have inspired researchers to study a range of bio-piezoelectric composite materials. By exploring these materials, researchers aim to understand better, how piezoelectricity can be controlled to promote bone growth and tissue regeneration. In this work, the prominent piezoelectric material, (Ba, Zr) TiO3-x(Ba,Ca)TiO3, abbreviated as BCZT, was selected as a possible bone growth enhancer in hydroxyapatite (HA) scaffolds. Initially, BCZT and hydroxyapatite (HA) powders were synthesized using the sol –gel method. Subsequently, various com...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 23, 2024 Category: Materials Science Authors: Fatemeh Zare Dehnov, Raziye Hayati, Lobat Tayebi Tags: RESEARCH ARTICLE Source Type: research

Strontium ‐loaded 3D intramedullary nail titanium implant for critical‐sized femoral defect in rabbits
In this study, an intramedullary nail shaped three-dimensional (3D)-printed porous titanium implant that is capable of releasing strontium ions was developed through a simple and cost-effective surface modification technique. The feasibility of this implant as a stand-alone solution was evaluated using a rabbit's segmental diaphyseal as a defect model. The strontium-loaded implant exhibited a favorable environment for cell adhesion, and mechanical properties that were commensurate with those of a rabbit's cortical bone. Radiographic, biomechanical, and histological analyses revealed a significantly higher amount of bone in...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - February 22, 2024 Category: Materials Science Authors: Shintaro Honda, Shunsuke Fujibayashi, Takayoshi Shimizu, Seiji Yamaguchi, Yaichiro Okuzu, Yusuke Takaoka, Soichiro Masuda, Mitsuru Takemoto, Toshiyuki Kawai, Bungo Otsuki, Koji Goto, Shuichi Matsuda Tags: RESEARCH ARTICLE Source Type: research