Causal Association Between Diabetes, Body Mass Index and Lichen Sclerosus: A Bidirectional Two-Sample Mendelian Randomization Analysis
CONCLUSION: This MR analysis demonstrated no significant causal relationship between DM and BMI with LS in both directions, which contradicts previous observational studies reporting a positive association. Potential confounding factors may contribute to previously observed associations, and further research is necessary.PMID:38689755 | PMC:PMC11060172 | DOI:10.2147/CCID.S450399 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Lin Liu Qiuli Zhang Jianmin Chang Kun Yang Source Type: research
Successful Treatment of Cutaneous Protothecosis Due to < em > Prototheca wickerhamii < /em > with Terbinafine
This report documents a case involving an 82-year-old male with Protothecosis. Histopathological analysis revealed granulomatous inflammation in the dermis, exhibiting necrotic features and hosting numerous non-budding spherical organisms. These organisms were positively stained using methenamine silver and periodic acid-Schiff stains, confirming identification as P. wickerhamii after validation through tissue culture and sequencing procedures. Initially, the patient received oral itraconazole at a dosage of 200 mg daily, accompanied by topical 1% naftifine-0.25% ketoconazole cream for a duration of 4 weeks, resulting in s...
Source: Clinical, Cosmetic and Investigational Dermatology - May 1, 2024 Category: Dermatology Authors: Yue Chen Aili Gao Yanan Ke Xin Zhou Li Lin Sha Lu Yumei Liu Source Type: research
A case report of Parry –Romberg syndrome
Changes made through two fat injection surgeries. Key Clinical MessageParry –Romberg syndrome is characterized by progressive dystrophy in one half of the face, which usually begins in childhood. Correct and timely diagnosis of this disease, as well as a multidisciplinary approach and timely surgical treatment to minimize the psychological effects and improve the patient' s appearance are of particular importance.AbstractParry –Romberg syndrome is characterized by progressive dystrophy or loss of subcutaneous tissue in one half of the face, which usually begins in childhood and continues with skin changes, and can also...
Source: Clinical Case Reports - May 1, 2024 Category: General Medicine Authors: Kiana Babaei,
Ali Rahnama,
Nora Shurvarzi,
Ali Movahedi Tags: CASE REPORT Source Type: research
Extramammary Paget Disease. Part I. Epidemiology, Pathogenesis, Clinical Features, and Diagnosis
Extramammary Paget disease (EMPD) is a rare skin cancer of apocrine-rich skin that mimics common inflammatory and infectious dermatoses, leading to delays in diagnosis and increased patient morbidity. Better clinical recognition of this entity, multidisciplinary patient assessment, and deeper understanding of the underlying pathophysiology are essential to improve patient care and disease outcomes. It is important to distinguish primary intraepithelial/micro-invasive EMPD from invasive EMPD or cases with adenocarcinoma arising within EMPD. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 1, 2024 Category: Dermatology Authors: Rohan R. Shah, Kalee Shah, Britney N. Wilson, Madeline Tchack, Klaus J. Busam, Andrea Moy, Mario M. Leitao, Miguel Cordova, Neil M. Neumann, Sharif Hosein, Mirabel Dafinone, Robert A. Schwartz, Anthony Rossi Source Type: research
Analysis of postoperative complications of orbital fracture
ConclusionStandardizing surgical techniques and implementing precise auxiliary technologies may reduce the incidence of complications and enhance the operation ’s success rate. (Source: Oral and Maxillofacial Surgery)
Source: Oral and Maxillofacial Surgery - May 1, 2024 Category: ENT & OMF Source Type: research
En-bloc excision of sacral squamous cell carcinoma with immediate reconstruction
AbstractSacral squamous cell carcinoma is an uncommon condition that may arise in scars following burns or in chronic wounds, such as an untreated pilonidal cyst. The aim of the present technical note is to describe a surgical technique aimed at minimizing local recurrence rates by en-bloc resection as well as providing immediate plastic reconstruction: 1. right-sided extended vertical rectus abdominis myo-cutaneous (VRAM) flap; 2. abdomino-perineal excision of the rectum with end colostomy; 3. en-bloc excision of the mass inclusive of gluteus maximus muscles and distal sacrectomy; 4. sacrectomy defect covered with VRAM fl...
Source: Updates in Surgery - May 1, 2024 Category: Surgery Source Type: research
Relevance of Human Herpesvirus 6 Reactivation in Drug Rash With Eosinophilia and Systemic Symptoms —Reply
In Reply We appreciate the interest in and valuable thoughts of Zhu et al on our international Delphi consensus on the treatment of adult patients with drug reaction with eosinophilia and systemic symptoms (DRESS). We thank them for their reflections on the role of human herpesvirus 6 (HHV-6) reactivation in DRESS. The authors address 3 important points. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 1, 2024 Category: Dermatology Source Type: research
Relevance of Human Herpesvirus 6 Reactivation in Drug Rash With Eosinophilia and Systemic Symptoms
To the Editor We read the article by Br üggen et al that outlined international consensus guidelines for the management of drug rash with eosinophilia and systemic symptoms (DRESS) with great interest. These were the first guidelines published that formally recommended routine screening for human herpesviruses: cytomegalovirus (CMV), Eps tein-Barr virus, and human herpesvirus 6A (HHV-6A) and 6B (HHV-6B). Consideration of antiviral medication (ie, valganciclovir or ganciclovir) for high CMV viral load is also an unprecedented formal recommendation. We fully support these recommendations, as viral reactivation has been asso...
Source: JAMA Dermatology - May 1, 2024 Category: Dermatology Source Type: research
Methotrexate Use and Risk of Interstitial Lung Disease in Dermatomyositis
This cohort study examines the association between methotrexate use and interstitial lung disease in patients with dermatomyositis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 1, 2024 Category: Dermatology Source Type: research
Definition and Diagnostic Criteria for Generalized Pustular Psoriasis
This consensus statement develops an international definition and diagnostic criteria for generalized pustular psoriasis using the modified Delphi model. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 1, 2024 Category: Dermatology Source Type: research
Retiform Ulceration and Bullae on the Bilateral Thighs
A man with a history of polysubstance use presents with new bullae on his bilateral lower extremities. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 1, 2024 Category: Dermatology Source Type: research
Use of oxazolidinones (linezolid or tedizolid) for the treatment of breast infections. A case series from a tertiary referral hospital
ConclusionsOxazolidinones could be considered as an alternative for treating breast infections. (Source: Infection)
Source: Infection - May 1, 2024 Category: Infectious Diseases Source Type: research
Expression of matrix metalloproteinase-9 (MMP-9) in human skin within 1 hour after injury through immunohistochemical staining: a pilot study
AbstractMatrix metalloproteinase-9 (MMP-9) is involved in tissue remodeling and in skin wound healing. The present study focuses on the MMP-9 expression in epidermal wound healing within 1 h after injury, to test whether MMP-9 can be used to estimate the time of injury in forensic practice.A sample consisting of 5 individuals undergoing surgery was analyzed. With the consent of the patients, sections of skin were removed from the surgical wound at predefined time intervals. For each subject, 8 sections were taken, one for each time interval defined at 0 ‘- 1’ − 3 ‘- 5’ − 10 ‘- 15’ − 30 ‘- 60’ ...
Source: International Journal of Legal Medicine - May 1, 2024 Category: Medical Law Source Type: research
Efficient skin lesion segmentation with boundary distillation
AbstractMedical image segmentation models are commonly known for their complex structures, which often render them impractical for use on edge computing devices and compromising efficiency in the segmentation process. In light of this, the industry has proposed the adoption of knowledge distillation techniques. Nevertheless, the vast majority of existing knowledge distillation methods are focused on the classification tasks of skin diseases. Specifically, for the segmentation tasks of dermoscopy lesion images, these knowledge distillation methods fail to fully recognize the importance of features in the boundary regions of...
Source: Medical and Biological Engineering and Computing - May 1, 2024 Category: Biomedical Engineering Source Type: research
Molecules, Vol. 29, Pages 2091: Antibiofilm Activity of Combretum micranthum G. Don Catechin & ndash;Sugar Phytocomplex on Pseudomonas aeruginosa
In this study, an extract from the leaves of Combretum micranthum G. Don, named Cm4-p, which was previously investigated for its antimicrobial activities, was assayed for its capacity to inhibit biofilm formation and/or to eradicate formed biofilms. The model strain P. aeruginosa PAO1 and its isogenic biofilm hyperproducer derivative B13 were treated with Cm4-p. Preliminary IR, UV-vis, NMR, and mass spectrometry analyses showed that the extract was mainly composed of catechins bearing different sugar moieties. The phytocomplex (3 g/L) inhibited the biofilm formation of both the PAO1 and B13 strains in a significant manner....
Source: Molecules - May 1, 2024 Category: Chemistry Authors: Viviana Teresa Orlandi Fabrizio Bolognese Luca Chiodaroli Ilaria Armenia Enrico Caruso Miryam Chiara Malacarne Tags: Article Source Type: research
