Stasis Dermatitis
This Patient Page describes the symptoms, possible causes, and treatment of stasis dermatitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Effect of Costimulatory Blockade With Abatacept in Plaque Psoriasis
This parallel-design, doube-blind randomized clinical trial evaluates whether abatacept could prevent psoriasis relapse after discontinuation of ustekinumab treatment in adults with plaque psoriasis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Evaluation and Treatment of Febrile Ulceronecrotic Mucha-Habermann Disease With Ruxolitinib and Tocilizumab
This case report describes treatment with tocilizumab and ruxolitinib for febrile ulceronecrotic Mucha-Habermann disease. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Perianal Chancres of Primary Syphilis,
This case report describes multiple small, punched-out ulcers within an erythematous and hypopigmented plaque in the perianal area. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Targeting Immune Checkpoints and Cytokines to Protect From Psoriasis Relapse
In contrast to the state of the field 10 years ago, the understanding of disease pathogenesis and the treatment goals for patients with psoriasis have changed enormously. A 75% improvement in the Psoriasis Area and Severity Index (PASI 75) is no longer the desirable treatment goal for dermatologists or for disease-experienced patients with plaque-type psoriasis. Physicians and patients now demand a PASI 90 or even a PASI 100. Identification of interleukin (IL) –17 and IL-23 as key mediators in the pathogenesis of psoriasis and the development of new biologics that target these pathways are major steps toward disease ...
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Widespread Erythematous Plaques With Prominent Telangiectases
A woman in her 50s with a history of nasal-type natural killer/T-cell lymphoma and chronic pulmonary coccidiomycosis was admitted for fever, hypotension, and asymptomatic widespread rash. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Novel Inheritance of a MEFV Variant and Pyrin-Associated Autoinflammation With Neutrophilic Dermatosis
This case series study examines the DNA of siblings and parents from a consanguineous family to find the genetic basis for pyrin-associated autoinflammation with neutrophilic dermatosis and to prescribe genotype-guided treatment. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 13, 2021 Category: Dermatology Source Type: research

Assessment of the Cutaneous Direct Immunofluorescence Assay
This quality improvement study examines the need for specific vs full-panel antibody testing in patients with skin diseases. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 6, 2021 Category: Dermatology Source Type: research

Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors
This case series analyzes the clinicopathologic characteristics and response to treatment of patients with persistent chemotherapy-induced alopecia after chemotherapy for breast cancer. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 29, 2021 Category: Dermatology Source Type: research

What Are We Waiting for? —Start Screening High-risk Individuals for Anal Cancer Now—Reply
In Reply We thank Terlizzi et al for their comments on our cohort study and insightful review of the current literature, which highlights the importance of anal dysplasia screening in high-risk individuals and the subsequent treatment of high-grade lesions to prevent the progression to anal cancer. We agree with their impassioned call to begin screening for and treating high-grade anal dysplasia in at-risk populations to address the alarming rise in anal cancer incidence in the US. However, we encourage clinicians to use a shared decision-making model with their patients given the lack of the highest-quality evidence on an...
Source: JAMA Dermatology - September 29, 2021 Category: Dermatology Source Type: research

Improvement of Chronic Kidney Disease –Associated Pruritus After Treatment With Intravenous Naloxone
This case report examines whether the use of naloxone has an antipruritic effect in patients with chronic kidney disease –associated pruritus. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 29, 2021 Category: Dermatology Source Type: research

What Are We Waiting for? —Start Screening High-risk Individuals for Anal Cancer Now
To the Editor We were delighted to read the cohort study by Arnold et al that found an association between anogenital warts (AGW) and increased anal cancer (AC) rates in people living with HIV (PLHIV) (4.4% vs 0.3%; P  
Source: JAMA Dermatology - September 29, 2021 Category: Dermatology Source Type: research

Minute Acral Melanoma
This case report describes a homogeneously pigmented spot on the patient ’s right sole and a parallel ridge pattern without asymmetry of colors and structures. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 29, 2021 Category: Dermatology Source Type: research

Lack of Transparency and Potential Bias in AI Data Sets and Algorithms
This scoping review analyzes the literature on algorithms assessing skin disease for data set criteria, emphasizing transparency and concerns about bias. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 22, 2021 Category: Dermatology Source Type: research

Mapping of Segmental and Partial Segmental Infantile Hemangiomas of the Face and Scalp
This cohort study aims to refine previous maps defining the distribution of facial segment hemangiomas and determine whether patterns of indeterminate hemangiomas are related to their segmental counterparts. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 22, 2021 Category: Dermatology Source Type: research

Rates of Opioid Prescriptions Obtained After Mohs Surgery
This cross-sectional study characterizes the frequency and changes over time (2009-2020) of opioid prescriptions following Mohs micrographic surgery. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 22, 2021 Category: Dermatology Source Type: research

Risk of Bias and Error From Data Sets Used for Dermatologic AI
In this issue of JAMA Dermatology, Daneshjou et al report on bias of medical data sets used for artificial intelligence (AI) and underreporting of relevant metainformation. Their findings are in line with those of other reports, showing that most current data sets for machine learning are biased in various ways. Biased data sets, however, may render a machine learning model unfit for practical use. This is because data sets are not simply a small part of the machine learning pipeline, but the essence of it. Machine learning models are not “intelligent” in the broad human sense; rather, they learn ways of proces...
Source: JAMA Dermatology - September 22, 2021 Category: Dermatology Source Type: research

Sirolimus for Vascular Malformations in Children
This randomized clinical trial assesses the efficacy and safety of sirolimus among children with slow-flow vascular malformations to better delineate the indications for treatment. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 15, 2021 Category: Dermatology Source Type: research

Out-of-Pocket Costs of Specialty Medications for Psoriasis and Psoriatic Arthritis Treatment in the Medicare Population
This cross-sectional study examines out-of-pocket costs associated with specialty medications for psoriasis and psoriatic arthritis among Medicare beneficiaries. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 15, 2021 Category: Dermatology Source Type: research

Cutaneous Lupus Erythematosus of the Vulvar Skin
This case report describes scarred erythematous patches on the labia majora, labia minora, and inguinal folds with no mucosal involvement. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 15, 2021 Category: Dermatology Source Type: research

Inflation-Adjusted Trends in Medicare Reimbursement for Common Dermatologic Procedures, 2007-2021
This cross-sectional study identifies trends in Medicare reimbursement for 46 common dermatologic procedures from 2007 to 2021. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 15, 2021 Category: Dermatology Source Type: research

Watchful Waiting and Tumor Behavior in Patients With Basal Cell Carcinoma
This cohort study evaluates reasons for watchful waiting and documents the natural course of basal cell carcinoma in patients who chose watchful waiting and reasons to initiate later treatment. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 8, 2021 Category: Dermatology Source Type: research

Postmarketing Cases of Enfortumab Vedotin –Associated Skin Reactions Reported as Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis
This case series study uses data from the FDA Adverse Event Reporting System to investigate a potential association between enfortumab vedotin treatment and Stevens-Johnson Syndrome and toxic epidermal necrolysis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 8, 2021 Category: Dermatology Source Type: research

Patient-Reported Outcome Measures as a Complement to Clinician-Reported Outcome Measures for Psoriasis Treatment
This cross-sectional study assesses patient-reported outcome measures as a complement to clinician-reported outcome measures in psoriasis treatment. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 8, 2021 Category: Dermatology Source Type: research

Clinical Evidence on “Watchful Waiting” in Basal Cell Carcinoma
Basal cell carcinoma (BCC) is estimated to be the most common cancer and primarily occurs in light-skinned, older patients. While accurate mortality rates are difficulty to calculate, they are estimated to be low (on the order of 0.12 per 100  000). For the vast majority of patients, BCC has an indolent course and an excellent prognosis with standard excision, Mohs surgery, or even topical treatments. These treatments are typically well tolerated, but, like any medical intervention, have risks and carry morbidity. For a variety of reas ons, patients sometimes want or need to avoid or delay treatment. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 8, 2021 Category: Dermatology Source Type: research

Ichthyosiform Rashes and Joint Pain in a Boy
A school-aged boy presents with generalized erythematous rashes for 4 years and ichthyosiform brownish plaques on his lower extremities and multiple erythematous confluent papules and plaques on his trunk and face. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 8, 2021 Category: Dermatology Source Type: research

UBA1 Variations in Neutrophilic Dermatosis Skin Lesions of Patients With VEXAS Syndrome
This case series study of 8 French men examines clinical and pathological skin manifestations and their pathophysiology in VEXAS syndrome. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 8, 2021 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement: JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, der...
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood
This population-based birth cohort study examines the association between atopic dermatitis and symptoms of depression at multiple points across childhood and adolescence and explores the role of potential mediating factors. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Patterns of Atopic Eczema Disease Activity From Birth Through Midlife in 2 British Birth Cohorts
This cohort study follows members of 2 British population-based birth cohorts to examine whether early life risk factors and participant characteristics predict patterns of atopic eczema through midlife. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Epidermolysis Bullosa Pruriginosa Treated With Baricitinib
This case report describes a 40-year-old man who had blistering and trauma-induced erosions shortly after birth and nodular prurigo-like lesions during his teenage years who presented with erythematous lichenified papules and nodules with crusts and milia over the scalp, trunk, and extremities. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Prevalence and Characterization of Itch in Pachyonychia Congenita
This survey study examines the prevalence and characteristics of itch in pachyonychia congenita. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Intertriginous Xanthomas —Pathognomonic Cutaneous Markers of Homozygous Familial Hypercholesterolemia
This case report describes yellow papules coalescing into plaques involving the medial and lateral canthi of eyes, finger web spaces of both hands, antecubital fossae, and nodular swellings over the elbows. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Recommendations on the Prevention of Squamous Cell Carcinoma in Solid Organ Transplant Recipients
This review reports the development and results of the Strategies for the Prevention of Skin Cancer in Solid Organ Transplant Recipients Delphi study. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2021 Category: Dermatology Source Type: research

Comparison of Treatments for H 1 Antihistamine –Refractory Chronic Spontaneous Urticaria
This network meta-analysis examines the effects of H1 antihistamines reported in randomized clinical trials for treatment in patients with chronic spontaneous urticaria. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 25, 2021 Category: Dermatology Source Type: research

Treatment Approaches and Outcomes in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
This cohort study examines culprit drugs and treatment strategies used in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis in European countries. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 25, 2021 Category: Dermatology Source Type: research

An Abscess Is Not a Descriptive Term but an Entity With a Universally Accepted Definition —Reply
In Reply We thank Lipsker for his feedback about our article that proposes harmonized morphological definitions for hidradenitis suppurativa (HS) assessment. We congratulate our colleagues for their first clinical definition for tunnels. Given the clinical and pathophysiological importance of these structures, the consistent and accurate assessment of tunnels in current and future studies is vital. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 25, 2021 Category: Dermatology Source Type: research

An Abscess Is Not a Descriptive Term but an Entity With a Universally Accepted Definition
To the Editor I read with interest the article by Frew et al and the accompanying Editorial. I thank the authors for referring to our previous contributions in this field. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 25, 2021 Category: Dermatology Source Type: research

Indurated Plaques With Telangiectasias on the Lower Limbs
A woman in her 70s presents with a 3-month history of episodic fever and painless cutaneous lesions on her lower limbs. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 25, 2021 Category: Dermatology Source Type: research

Patient Quality of Life After Interpolated Flap Repair of Nasal Mohs Surgery Defects
This cohort study uses the Skin Cancer Index to evaluate patient quality of life after Mohs micrographic surgery and interpolation flap reconstruction for patients with nasal skin cancers. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 25, 2021 Category: Dermatology Source Type: research

Sentinel Lymph Node Biopsy in Cutaneous Melanoma —Where Do We Stand?
This Viewpoint examines the utility of sentinel lymph node biopsy in the treatment of cutaneous melanoma. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 18, 2021 Category: Dermatology Source Type: research

Efficacy and Safety of Bimekizumab in Moderate to Severe Hidradenitis Suppurativa
This randomized clinical trial assesses whether bimekizumab is efficacious and safe when used to treat patients with hidradenitis suppurativa. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 18, 2021 Category: Dermatology Source Type: research

Efficacy and Safety of Abrocitinib Plus Topical Therapy in Adolescents With Moderate-to-Severe Atopic Dermatitis
This randomized clinical trial examines the efficacy and safety of abrocitinib plus topical therapy in adolescents with moderate-to-severe atopic dermatitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 18, 2021 Category: Dermatology Source Type: research

Primary Cutaneous Endometriosis Presenting as an Umbilical Nodule
This case report describes an umbilical mass that had been present for a year. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 18, 2021 Category: Dermatology Source Type: research

Prevalence of Central Sensitization in Patients With Hidradenitis Suppurativa
This cross-sectional, case-control study assesses the prevalence of central sensitization in patients with hidradenitis suppurativa compared with sex- and age-matched controls in the Netherlands. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 18, 2021 Category: Dermatology Source Type: research

Differences Between Children and Adults With Hidradenitis Suppurativa
This cohort study examines clinical characteristics and health care utilization patterns of pediatric vs adult patients with hidradenitis suppurativa. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 11, 2021 Category: Dermatology Source Type: research

Using Billing Codes From EHRs to Estimate Skin Cancer Counts
This cohort study assesses whether standard diagnostic and procedural codes present in the electronic health records (EHRs) at a single health care system are a valid proxy for estimating the number of overall skin cancers. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 11, 2021 Category: Dermatology Source Type: research

Role of Eosinophils in Angiolymphoid Hyperplasia With Eosinophilia
This case report describes a man in his 50s with a 14-year history of angiolymphoid hyperplasia with eosinophilia and nodular tumors in both preauricular regions. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 11, 2021 Category: Dermatology Source Type: research

Racial and Ethnic Distribution of Patients Hospitalized With Hidradenitis Suppurativa, 2008-2018
This cohort study assesses hidradenitis suppurativa –related hospitalizations in the US from 2008 to 2018 to understand the racial breakdown among those with hidradenitis suppurativa. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 11, 2021 Category: Dermatology Source Type: research

Clinical Settings and Demographic Characteristics of Patients With Sunburn
This cross-sectional study examines sunburn in claims data as well as the clinical settings and demographic characteristics of patients who receive sunburn diagnoses. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 11, 2021 Category: Dermatology Source Type: research