Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis
This systematic review presents evidence-based dietary recommendations for adults with psoriasis or psoriatic arthritis from the Medical Board of the National Psoriasis Foundation. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 20, 2018 Category: Dermatology Source Type: research

Assessment of a Predictive Scoring Model for Dermoscopy of Subungual Melanoma In Situ
This cohort study identifies the dermoscopic features of subungual melanoma in situ in a Korean population and assesses a predictive scoring model that distinguishes the diagnosis of subungual melanoma in situ from longitudinal melanonychia in patients with pigmented nails. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 20, 2018 Category: Dermatology Source Type: research

Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa
In Reply We are grateful for the very constructive and positive feedback from Kokolakis and Sabat regarding our newly proposed Severity Assessment of Hidradenitis Suppurativa (SAHS) score. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 20, 2018 Category: Dermatology Source Type: research

Distinguishing Mild, Moderate, and Severe Hidradenitis Suppurativa
To the Editor We read with great interest the article by Hessam and colleagues published in a recent issue ofJAMA Dermatology describing the evaluation of a novel comprehensive score for hidradenitis suppurativa (HS) severity assessment. A highly inflammatory destructive disease, HS mainly affects axillary, inguinal, and perianal body areas. Patients with HS show signs of systemic inflammation and additionally often have metabolic syndrome, spondyloarthritis, or inflammatory bowel disease. Furthermore, HS has a tremendous negative effect on life quality and leads to reduced life expectancy. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 20, 2018 Category: Dermatology Source Type: research

A Twitter Analysis of the #DontFryDay Campaign
This study assessed the reach of the “Don’t Fry Day” campaign on Twitter, using the hashtag #DontFryDay, and identified what types of individuals and/or tweeters are engaging in the campaign. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 20, 2018 Category: Dermatology Source Type: research

Persistent Malar Erythema With Atrophy in a Young Woman
A young woman had asymptomatic, facial redness that flared in sunlight, previously treated with doxycycline and topical sulfacetamide with no effect; on her cheeks and nasal bridge there were multiple erythematous, annular plaques with focal areas of atrophy. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 20, 2018 Category: Dermatology Source Type: research

Contributions by MC1R Variants to Melanoma Risk in Males and Females
This case-control study evaluates the association of melanocortin-1-receptor (MC1R) with melanoma risk in males vs females, adjusting for risk factors such as age, pigmentation, phenotype, signs of skin damage, and sun exposure. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 13, 2018 Category: Dermatology Source Type: research

Efficacy and Safety of Ozenoxacin for Treatment of Patients With Impetigo
This randomized clinical trial evaluates the efficacy, safety, and tolerability of ozenoxacin cream vs placebo in children and adults with impetigo. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 13, 2018 Category: Dermatology Source Type: research

Problematic End Points in a Keratinocyte Carcinoma Chemoprevention Trial —Reply
In Reply We appreciate the close scrutiny of our published work and the opportunity to elaborate on the end points we used for analysis of the trial data. The VAKCC Trial primary end point was the rate of occurrence of keratinocyte carcinoma (KC) over the course of the 4-year trial. In the process of creating and executing this trial, however, the study team explicitly discussed that there were other important outcomes. In particular, while we did not have evidence to guide our estimation of the timing and duration of the effect of our intervention, if any, on the occurrence of KC, basal cell carcinoma, or squamous cell ca...
Source: JAMA Dermatology - June 13, 2018 Category: Dermatology Source Type: research

Problematic End Points in a Keratinocyte Carcinoma Chemoprevention Trial
To the Editor Treatment with topical fluorouracil, 5%, compared with placebo reduced risk of surgically treated squamous cell carcinoma (SCC) and Mohs surgery for keratinocyte carcinoma (KC) for 1 year, according to a randomized clinical trial (RCT) report. However, because neither of these outcomes was prespecified, these findings should be interpreted very cautiously and should not sway clinical practice. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 13, 2018 Category: Dermatology Source Type: research

An Elderly Woman With Painful Buttock and Vulvar Ulcers
A woman in her 80s presented with somnolence, fatigue, lower urinary tract symptoms, and progressively worsening vulvar and buttock pain. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 13, 2018 Category: Dermatology Source Type: research

Association of RAR β Expression With Lichen Sclerosus–Associated Vulvar Squamous Cell Carcinoma
This case-control study examines the association of retinoic acid receptor β tumor-suppressor gene with the onset and progression of lichen sclerosus–associated vulvar squamous cell carcinoma. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 13, 2018 Category: Dermatology Source Type: research

Dynamic Trichoscopy
This Viewpoint discusses how the dermoscope is a practical instrument for use in routine practice and describes how its shortcomings can be overcome with increasing familiarity with the use of dynamic vs static trichoscopy. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 6, 2018 Category: Dermatology Source Type: research

Identifying a Core Domain Set to Assess Psoriasis in Clinical Trials
This Delphi survey of patients, health care professionals, and other stakeholders identifies a core set of 6 domains that should be measured in all clinical trials for psoriasis therapies. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 6, 2018 Category: Dermatology Source Type: research

Sun Protection Among Organ Transplant Recipients After Participation in a Skin Cancer Research Study
This study investigates the use of sun protection among organ transplant recipients after participation in a skin cancer research study. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 6, 2018 Category: Dermatology Source Type: research

Core Outcome Sets for Psoriasis Clinical Trials
Standardized and relevant psoriasis-specific outcome measures would contribute to a better understanding of the benefits of a growing list of highly effective therapies. To this end, in this issue ofJAMA Dermatology, Callis Duffin et al present the results of an effort to define core outcome sets (COSs) for clinical trials of psoriasis. Under the auspices of the International Dermatology Outcome Measures group, the authors conducted a Delphi survey and determined that the following 6 domains should be addressed in all psoriasis trials: (1) psoriatic skin manifestations (including location), (2) an investigator global asses...
Source: JAMA Dermatology - June 6, 2018 Category: Dermatology Source Type: research

Polymorphic Erythematous Macules and Plaques With Dysesthesia
A woman in her 50s presented with a 2-year history of disseminated dermatosis involving the trunk and limbs; the dermatosis was characterized by polymorphic erythematous macules and plaques with elevated and indurated borders without evanescence to pressure. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 6, 2018 Category: Dermatology Source Type: research

Hemophagocytic Lymphohistiocytosis in Cutaneous T-Cell Lymphoma
This case series examines the characteristics of cutaneous T-cell lymphoma associated with hemophagocytic lymphohistiocytosis and analyzes the presenting signs and symptoms, therapeutic options, and outcomes. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 6, 2018 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement:JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, derm...
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Immunotherapy and Skin Side Effects
This Patient Page defines the cancer treatment immunotherapy and describes its potential side effects, particularly of the skin. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

“What’s in a Name?”—The Story Behind the Eponym Munchausen
Munchausen syndrome is an eponymous designation used to describe the circumstances that occur when patients, with insight into their actions, intentionally inflict on themselves or attempt to mimic a medical condition to assume the role of the patient. While most patients with Munchausen syndrome attempt to simulate an internal or surgical disease, rarely there is a crossover of dermatitis artifacta and Munchausen syndrome. These syndromes can be frustrating and challenging for both the clinician and the patient. While the condition is very serious, the way it received its name is quite whimsical. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Endurance —Frostbite, Then and Now
The 2018 Olympics remind us of what it means to truly brave the odds. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Island Pedicle Flap —Its Place in History
The island pedicle flap, also known as the V-to-Y advancement flap, is highly regarded by reconstructive surgeons owing to its robust blood supply, color and textural match, minimization of tension, and inherent adaptability. Although used by dermatologists in contemporary practice, particularly for defects on the nose and central face, the V-to-Y flap ’s origins and historical contextualization are not as well known. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Thomas Hindson and Discovery of Ascorbic Acid to Treat Prickly Heat
Dr Thomas Hindson was born in northern England in 1934. After attending St John ’s College in Cambridge for medical school, he worked as a dermatologist at St Bartholomew’s Hospital. In 1960, he enlisted as a serviceman in the Royal Army Medical Corps and was later commissioned to the Armed Services in 1963. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Incorrect Denominator
This article was corrected online. (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Mogamilizumab Prior to HSCT and GVHD in Patients With CTCL
This case series describes the occurrence of graft-vs-host-disease (GVHD) in patients with cutaneous T-cell lymphomas (CTCLs) treated with the CC chemokine receptor 4 (CCR4) antibody mogalizumab prior to allogeneic hematopoietic stem cell transplantation (HSCT). (Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

June 2018 Issue Highlights
(Source: JAMA Dermatology)
Source: JAMA Dermatology - June 1, 2018 Category: Dermatology Source Type: research

Lentigo Maligna Treated With Off-Label Neoadjuvant Imiquimod
This medical record review examines the rate of recurrence of lentigo maligna in patients treated with neoadjuvant topical imiquimod, 5%, cream prior to conservatively staged excisions. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 30, 2018 Category: Dermatology Source Type: research

Trichophyton erinacei Transmitted to a Pregnant Woman From Her Pet Hedgehogs
This case report describes a pregnant woman who developed tinea manus fromTrichophyton erinacei infection transmitted to her from her pet hedgehogs. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 30, 2018 Category: Dermatology Source Type: research

Prevalence of Skin Cancer Examination Among Indoor Tanning Bed Users
This study uses weighted national survey data to examine the prevalence of skin cancer examinations among users of indoor tanning beds. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 30, 2018 Category: Dermatology Source Type: research

Lentigo Maligna —Challenges, Observations, Imiquimod, Confocal Microscopy, and Personalized Treatment
The wordmelanoma imparts considerable fear and concern in patients. Fortunately, for patients with the lentigo maligna (LM) subtype of melanoma in situ, there is overall good prognosis. The challenge of LM, however, is that it has the highest rate of local recurrence (approximately  20%) of all melanoma subtypes when treated by standard surgical excision alone, owing to frequent, unpredictable, subclinical extension. To reduce this risk, the use of Mohs surgery or staged excision has consistently demonstrated lower recurrence rates of 0.3% to 2.2% yet requires larger surgica l margins for histological clearance than...
Source: JAMA Dermatology - May 30, 2018 Category: Dermatology Source Type: research

Adolescents ’ Perspectives on Atopic Dermatitis Treatment
This qualitative study examines the beliefs, experiences, and preferences of adolescents with atopic dermatitis toward their treatment via focus groups interviews. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 30, 2018 Category: Dermatology Source Type: research

Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa
This cross-sectional cohort analysis of electronic health records from a large US database evaluates overall and subgroup prevalence of Crohn disease among patients with hidradenitis suppurativa. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 23, 2018 Category: Dermatology Source Type: research

Topical Rapamycin in Patients With Facial Angiofibromas
This randomized clinical trial examines the efficacy and safety of topical rapamycin therapy for treatment of patients with tuberous sclerosis complex –related facial angiofibromas. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 23, 2018 Category: Dermatology Source Type: research

Immunotherapy-Related Eruption Limited to Sites of Melanoma Metastases
This case report describes 2 patients with cutaneous eruptions secondary to immunotherapy for metastatic melanoma limited to sites of locoregional melanoma metastases. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 23, 2018 Category: Dermatology Source Type: research

Mogamilizumab Prior to Allogeneic Hematopoietic Stem Cell Transplantation
This case series describes characteristics of 8 patients with mycosis fungoides or S ézary syndrome who received mogamulizumab before allogeneic hematopoietic stem cell transplantation and any resulting graft-vs-host disease–related complications. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 23, 2018 Category: Dermatology Source Type: research

Topical Sirolimus to Treat Tuberous Sclerosis Complex
Tuberous sclerosis complex (TSC) causes the formation of hamartomatous tumors in multiple organs. Facial angiofibromas frequently arise during childhood and can be a source of patient distress owing to bleeding and effects on appearance. The standard treatment is surgical, delivered by multiple modalities, including lasers, shave excision, dermabrasion, electrosurgery, or cryosurgery. These approaches are effective but can create concerns about the potential for scarring, pain, anesthesia risk, postoperative recovery, and the need for repeated procedures delivered in the office or operating room. Consequently, there has be...
Source: JAMA Dermatology - May 23, 2018 Category: Dermatology Source Type: research

Linear Keratotic Lesions in a Young Woman
A woman in her 20s presented with linear hyperkeratotic papules on her right arm in a Blaschkoid pattern. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 23, 2018 Category: Dermatology Source Type: research

Sirolimus Gel vs Placebo for Facial Angiofibromas in Patients With Tuberous Sclerosis Complex
This randomized clinical trial assesses the efficacy and safety of sirolimus gel, 0.2% vs placebo for treatment of angiofibromas and skin lesions in adult and pediatric patients with tuberous sclerosis complex. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 19, 2018 Category: Dermatology Source Type: research

Whole-Body Distribution and Clinical Association of Telangiectases in Systemic Sclerosis
This cross-sectional study evaluates the association between the presence and distribution of telangiectases and the severity of vasculopathy in patients with systemic sclerosis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Efficacy of Guselkumab Compared With Adalimumab and Placebo for Psoriasis in Specific Body Regions
This secondary analysis of 2 randomized clinical trials evaluates the effect of guselkumab vs adalimumab or placebo on psoriasis in specific difficult-to-treat body regions. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Improvement in Ulcerative Necrobiosis Lipoidica After JAK-Inhibitor Therapy for Polycythemia Vera
This case report describes a patient whose ulcerative necrobiosis lipoidica improved after being treated for a different condition, polycythemia vera, with Janus kinase inhibitor. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Teaching Intuitive Visual Diagnosis of Melanoma
This diagnostic study compares the training efficacy of a novel web-based application to the publicly available Internet Curriculum For Melanoma Early Detection Skin Education Series to determine if intuitive visual diagnosis training is superior to a traditional rule-based algorithm in the diagnosis of melanomas. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Timing and Number of Cutaneous Squamous Cell Carcinomas in Transplant Recipients
This cohort study of 3652 recipients of solid organ transplants examines the timing and number of cutaneous squamous cell carcinomas that developed after transplantation. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Necrotizing Anogenital Ulcer in a Healthy 8-Month-Old Male
A healthy 8-month-old male infant was admitted for management of a rapidly progressive, painful anogenital ulcer; the lesion had developed acutely over 48 hours and had an associated symptom, but no fevers, chills, or other systemic symptoms. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Frontalis Myocutaneous Transposition Flap for Forehead Defect Reconstruction
This case series of 12 patients with large, deep forehead defects secondary to Mohs surgery assesses whether the frontalis myocutaneous transposition flap represents a good alternative for the reconstruction of forehead defects. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 16, 2018 Category: Dermatology Source Type: research

Cost-effectiveness of Skin Cancer Referral and Consultation Using Teledermoscopy in Australia
This study uses a decision-analytic model to assess the cost-effectiveness of teledermoscopy as a referral mechanism for skin cancer diagnosis and management in Australia. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 9, 2018 Category: Dermatology Source Type: research

Interest and Uptake of MC1R Testing for Melanoma Risk in a Diverse Primary Care Population
This randomized clinical trial examines the prevalence of interest in and uptake ofMC1R testing in the general population and examines patterns across demographic and skin cancer risk factors. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 9, 2018 Category: Dermatology Source Type: research

Recurrent Unilateral Periorbital Edema Associated With Subcutaneous Cysticercosis
This case report describes a patient with recurrent unilateral periorbital edema caused by subcutaneous cysticercosis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 9, 2018 Category: Dermatology Source Type: research

Demographic, Academic, and Publication Factors Associated With Academic Dermatology Career Selection
This cohort study examines associations between demographic, academic, and publication factors and dermatology trainees ’ initial choice of academic vs private practice careers. (Source: JAMA Dermatology)
Source: JAMA Dermatology - May 9, 2018 Category: Dermatology Source Type: research