Blistering Distal Dactylitis
This case report describes a case of blistering distal dactylitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 10, 2018 Category: Dermatology Source Type: research

Treatment of Severe Hailey-Hailey Disease With Apremilast
This case series describes 4 adult patients who received apremilast (a phosphodiesterase-4 inhibitor) for treatment-resistant Hailey-Hailey disease. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 10, 2018 Category: Dermatology Source Type: research

Risk of Melanoma in Moderately Dysplastic Nevi Excisionally Biopsied but With Positive Margins
This multicenter cohort study examines the outcomes and risk for the development of subsequent cutaneous melanoma in moderately dysplastic nevi excisionally biopsied without residual clinical pigmentation but with positive histologic margins, observed for 3 years or more. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 10, 2018 Category: Dermatology Source Type: research

Observation of Moderately Dysplastic Nevi With Positive Margins
The management of dysplastic nevi is a quotidian part of the clinical practice of dermatology, yet even directors of pigmented lesion clinics in the United States demonstrate significant practice variation with observation or therapeutic excision of dysplastic nevi. This scenario is particularly true for biopsies of dysplastic nevi that have histologically positive margins. A 2015 consensus statement summarizing this practice gap included a call for further study of this common clinical question. There are several important challenges in establishing evidence-based guidelines for the management of dysplastic nevi, and thus...
Source: JAMA Dermatology - October 10, 2018 Category: Dermatology Source Type: research

Association Between Psoriasis and Sexual and Erectile Dysfunction in Epidemiologic Studies
This systematic review evaluates the main characteristics of the studies of psoriasis and sexual dysfunction (SD) or erectile dysfunction (ED), including level of evidence, tools used to assess SD or ED, and prevalence and incidence of SD or ED. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 10, 2018 Category: Dermatology Source Type: research

Hair Regrowth After Long-standing Alopecia Totalis and Atopic Dermatitis Treated With Dupilumab
This case report describes hair regrowth in a patient with long-standing alopecia totalis and atopic dermatitis treated with dupilumab. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 10, 2018 Category: Dermatology Source Type: research

Acrodermatitis Continua of Hallopeau
This case report describes the occurrence of acrodermatitis continua of Hallopeau being mistaken for recurrent cellulitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 3, 2018 Category: Dermatology Source Type: research

Prescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers
This systematic review and meta-analysis of 5 clinical trials examines the association of different exercise interventions with venous leg ulceration healing when used as an adjuvant to any form of compression. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 3, 2018 Category: Dermatology Source Type: research

Efficacy and Safety of Antibiotic Therapy in Early Cutaneous Lyme Borreliosis
This network meta-analyses of 19 randomized clinical trials conducted in the United States and Europe examines antibiotic agents and treatment modalities to assess treatment effectiveness and drug-related adverse outcomes in early cutaneous Lyme borreliosis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 3, 2018 Category: Dermatology Source Type: research

Introducing “Images in Dermatology”
It is often said that dermatology is a “visual specialty.” While it is more than that, there is no escaping the central importance of the clinical examination to dermatologic diagnosis. The appearance, the morphology, the shape and distribution of lesions—these features are the illustration of illness, the manifestation of cutaneou s or even systemic disease. The critical role of the physical examination, imparting the ability to make a diagnosis visually, is part of the art of dermatology and is shared by few other medical specialties. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 3, 2018 Category: Dermatology Source Type: research

Exercise for Leg Ulcers
In this issue ofJAMA Dermatology, Jull et al use meta-analysis to suggest an additional healing benefit of exercise in patients with venous leg ulcers (VLUs). Combining and analyzing data from 5 relatively small studies (the largest with 63 participants), the authors found that 61% of participants (57 of 94) who exercised and received compression healed at 12 weeks compared with 46% (44 of 96) of participants who received compression alone. Although the type of exercise administered varied among the trials, the results were driven by 2 studies that used progressive resistance exercises involving calf muscle strengthening c...
Source: JAMA Dermatology - October 3, 2018 Category: Dermatology Source Type: research

Alopecia Universalis and Chronic Graft-vs-Host Disease Treated With Ruxolitinib
This case report describes alopecia universalis and chronic graft-vs-host disease occurring after allogenic hematopoietic stem-cell transplantation and treated with ruxolitinib. (Source: JAMA Dermatology)
Source: JAMA Dermatology - October 3, 2018 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement:JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, derm...
Source: JAMA Dermatology - October 1, 2018 Category: Dermatology Source Type: research

October 2018 Issue Highlights
(Source: JAMA Dermatology)
Source: JAMA Dermatology - October 1, 2018 Category: Dermatology Source Type: research

Multispectral Optoacoustic Tomography for Vascular Malformations
This pilot study evaluates the use of multispectral optoacoustic tomography for assessment of biomarkers among patients with arteriovenous and venous malformation. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 26, 2018 Category: Dermatology Source Type: research

Differences in Use of Outpatient Dermatology Services in the United States
This study examines nationwide differences in demographic and socioeconomic characteristics and use of outpatient dermatologic care among Medical Expenditure Panel Survey respondents. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 26, 2018 Category: Dermatology Source Type: research

Identifying Disparities in Dermatology
(Source: JAMA Dermatology)
Source: JAMA Dermatology - September 26, 2018 Category: Dermatology Source Type: research

Vasculitis
This Patient Page describes vasculitis, focusing especially on skin vasculitis, how to recognize it, and how it might be treated. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 26, 2018 Category: Dermatology Source Type: research

Juvenile Spring Eruption Associated With Parvovirus B19 Infection
This case report describes the occurrence of juvenile spring eruption associated with parvovirus B19 infection. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 26, 2018 Category: Dermatology Source Type: research

Use of Actinic Keratosis Destruction in the Medicare Part B Fee-for-Service Population
This billing claims analysis uses the Medicare Part B Physician/Supplier Procedure Summary Master Files and National Summary Data to evaluate trends in the use and costs of actinic keratosis destruction. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 19, 2018 Category: Dermatology Source Type: research

Antiphospholipid Syndrome Following Pembrolizumab Treatment of Stage IIIB Unresectable Melanoma
The case report describes the occurrence of antiphospholipid syndrome following pembrolizumab treatment of stage IIIB unresectable melanoma. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 19, 2018 Category: Dermatology Source Type: research

Translating Data on Trends in Disease Management to Decisions
Quantifying health care utilization is an important first step in understanding how to efficiently and effectively deliver health care to patients. Actinic keratoses (AKs) are among the most common clinical diagnoses encountered by dermatologists, and treatment aims to reduce patient discomfort and potential for malignant transformation. Given an aging population, disease burden will likely increase, highlighting the need for understanding trends in AK treatment and reimbursement. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 19, 2018 Category: Dermatology Source Type: research

Management of Complex Arteriovenous Malformations Using a Novel Combination Therapeutic Algorithm
This case series assesses the efficacy and tolerability of sirolimus as an adjuvant therapy for endovascular embolization in the management of complicated extracranial head and neck arteriovenous malformations. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 19, 2018 Category: Dermatology Source Type: research

Glycolic Acid Plus Lovastatin-Cholesterol Combination Cream to Treat Congenital Ichthyoses
This case series evaluates the use of topical glycolic acid plus a lovastatin-cholesterol combination cream to treat autosomal recessive congenital ichthyoses. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 12, 2018 Category: Dermatology Source Type: research

Trajectories of Nevus Development From Age 3 to 16 Years in the Colorado Kids Sun Care Program Cohort
This longitudinal cohort study describes nevus acquisition from the ages of 3 to 16 years among white youths and evaluates variation by sex, Hispanic ethnicity, and body sites that are chronically vs intermittently exposed to the sun. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 12, 2018 Category: Dermatology Source Type: research

Management of Flat Pigmented Spitz and Reed Nevi in Children
This database study evaluated the efficacy of monitoring flat symmetric pigmented spitzoid-looking lesions in prepubertal children. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 12, 2018 Category: Dermatology Source Type: research

Picosecond Laser Treatment for Acquired Bilateral Nevus of Ota –like Macules
This report of cases describes the use of picosecond laser to treat acquired bilateral nevus of Ota –like macules. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 12, 2018 Category: Dermatology Source Type: research

Complementary and Alternative Medicine Therapies for Psoriasis
This systematic review summarizes the evidence on the efficacy of the most studied complementary and alternative medicine therapies for treatment of plaque psoriasis and discusses those treatments with the most robust available evidence. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 5, 2018 Category: Dermatology Source Type: research

Comparison of Dermatologist Density Between Urban and Rural Counties in the United States
This study analyzes county-level data from nationwide US data to compare dermatologist density between urban and rural areas. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 5, 2018 Category: Dermatology Source Type: research

Laser Treatment Performed Decades After Napalm Burns
This case report describes the use of laser treatment beginning in 2015 to treat napalm burns sustained by the famous Vietnamese “Napalm Girl” in 1972. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 5, 2018 Category: Dermatology Source Type: research

Predictions, Surprises, and the Future of the Dermatology Workforce
With the debut of managed care in the 1980s, experts in the physician workforce portended an impending surplus of specialist physicians, including dermatologists. Despite these dire predictions, a dermatology workforce shortage was identified in the late 1990s, with an associated geographical imbalance. Since then, the overall shortage has only modestly abated, so it would not be surprising to find that an urban-rural workforce maldistribution has persisted. Indeed, in this issue ofJAMA Dermatology, Feng and colleagues present physician data from 1995 to 2013 demonstrating that the maldistribution of dermatologists may wel...
Source: JAMA Dermatology - September 5, 2018 Category: Dermatology Source Type: research

Necrotic Plaque on the Distal Nose With Diffuse Crateriform Nodules
A man in his 30s presented with a progressively necrotic plaque on the nose, scattered nodules on the extremities, and erythematous papules on the arms and legs. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 5, 2018 Category: Dermatology Source Type: research

Treatment of Refractory Granuloma Faciale With Intralesional Rituximab
This case series describes the results of intralesional rituximab treatment in men with granuloma faciale. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 5, 2018 Category: Dermatology Source Type: research

Congenital Syphilis —Still a Shadow on the Land
The US Surgeon General, Thomas Parran, chose an ominous phrase —Shadow on the Land—as the title of his best-selling book about syphilis, published in 1937. It was not without reason. At the time, according to Parran, nearly 700 000 Americans were being treated for syphilis, constituting only a fraction of the approximately 1.7 million that he estimated needed treatment. At le ast 500 000 new infections occurred in the United States each year, Parran stated, including 60 000 cases of congenital syphilis. Cardiovascular syphilis claimed 40 000 lives each year. The arsenic-containing compound salvarsan, su...
Source: JAMA Dermatology - September 4, 2018 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement:JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, derm...
Source: JAMA Dermatology - September 1, 2018 Category: Dermatology Source Type: research

September 2018 Issue Highlights
(Source: JAMA Dermatology)
Source: JAMA Dermatology - September 1, 2018 Category: Dermatology Source Type: research

Analysis of the Effect of Gentian Violet on Apoptosis and Proliferation in Cutaneous T-Cell Lymphoma in an In Vitro Study
This preclinical in vitro study identifies novel small molecules that induce extrinsic apoptosis and serve as an alternative treatment for cutaneous T-cell lymphoma. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 29, 2018 Category: Dermatology Source Type: research

Program Director and Resident Perspectives on New Parent Leave in Dermatology Residency
This study investigates how new parent leave policies are perceived by dermatology program directors and residents. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 29, 2018 Category: Dermatology Source Type: research

A Child With Multiple Hypopigmented Macules on the Abdomen
A child presented with multiple, asymptomatic, scattered white macules on the lower abdomen and pubic area, which were present at birth and had gradually increased in size and number; there was no history of any systemic disorder and no family history of similar lesions. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 29, 2018 Category: Dermatology Source Type: research

Risk Factors for Dupilumab-Associated Conjunctivitis in Patients With Atopic Dermatitis
This case series evaluates 12 patients with atopic dermatitis who experienced conjunctivitis secondary to injectable dupilumab treatment to investigate severity and common risk factors for secondary conjunctivitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 29, 2018 Category: Dermatology Source Type: research

How Should AI Screen for Skin Cancer and Deliver Diagnostic Predictions to Patients?
This Viewpoint describes the current state of deep learning algorithms used in artificial intelligence and discusses their potential use in dermatology screening and diagnosis, including mobile apps for patient use. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 22, 2018 Category: Dermatology Source Type: research

Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa
This case-control study investigates the mesenchymal stem cell profile in patients with hidradenitis suppurativa and in healthy controls, with punch biopsy samples from axillary skin analyzed for immunophenotypic profiles. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 22, 2018 Category: Dermatology Source Type: research

Combined Reflectance Confocal Microscopy –Optical Coherence Tomography for Basal Cell Carcinoma
This pilot study of 85 lesions from 55 patients assesses the accuracy of a handheld imaging device that combines reflective confocal microscopy (RCM) and optical coherence tomography (OCT) to detect, diagnose, and estimate the depth of basal cell carcinoma in adults. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 22, 2018 Category: Dermatology Source Type: research

Dupilumab for the Treatment of Recalcitrant Bullous Pemphigoid
This case report describes the use of dupilumab to treat recalcitrant bullous pemphigoid. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 22, 2018 Category: Dermatology Source Type: research

Palatal Swelling in a Patient With Refractory Leukemia
A man in his 20s with acute myeloid leukemia presented with rapidly growing, severely painful oral lesions on the left hard palate. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 22, 2018 Category: Dermatology Source Type: research

Association Between Autoantibody Phenotype and Cutaneous Adverse Reactions to Hydroxychloroquine
This cohort study examines myositis-specific autoantibodies observed during hydroxychloroquine therapy in patients with dermatomyositis to determine whether certain subsets of patients are more likely to experience a skin eruption. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 22, 2018 Category: Dermatology Source Type: research

Interpretation of Melanocytic Lesions in the Digital Era vs Traditional Microscopy
This study of 87 pathologists compares the use of digital whole-slide imaging vs traditional microscopy in pathologists ’ ability to accurately interpret melanocytic lesions and reproduce correct diagnoses. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 15, 2018 Category: Dermatology Source Type: research

Self-reported Patient Motivations for Seeking Cosmetic Procedures
This multicenter observational study assesses the importance of self-reported factors that motivate patients to undergo minimally invasive cosmetic surgical procedures. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 15, 2018 Category: Dermatology Source Type: research

Resolution of Atypical Lichen Myxedematosus After Sofosbuvir-Velpatasvir Treatment for Hepatitis C
This case report describes a patient with lichen myxedematosus that resolved after sofosbuvir-velpatasvir treatment for hepatitis C infection. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 15, 2018 Category: Dermatology Source Type: research

Aprepitant for the Treatment of Pruritus in S ézary Syndrome
This randomized clinical trial assesses whether treatment with the neurokinin 1 receptor antagonist aprepitant decreases pruritus vs placebo in patients with S ézary syndrome. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 15, 2018 Category: Dermatology Source Type: research