Skin-Colored Nodule on the Scalp of a Middle-Aged Man
An otherwise healthy man in his 40s presents with an asymptomatic nodule on his scalp; examination revealed a skin-colored, firm, nontender nodule with overlying normal skin on the right occipital region. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 23, 2020 Category: Dermatology Source Type: research

Error in Byline
This article has been correcte d online. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 23, 2020 Category: Dermatology Source Type: research

Characterizing Disease Features and Other Medical Diagnoses in Patients With Pityriasis Rubra Pilaris
This survey-based study examines the prevelence, disease features, and medical diagnoses in a large sample of patients with pityriasis rubra pilaris. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 23, 2020 Category: Dermatology Source Type: research

Safety and Efficacy of VP-102 in Children and Adults With Molluscum Contagiosum
These randomized clinical trials examine the efficacy and safety of VP-102, a drug-device combination containing cantharidin, 0.7% (w/v), in treatment of patients with molluscum contagiosum. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 23, 2020 Category: Dermatology Source Type: research

Cellulitis
This Patient Page describes the symptoms, possible causes, and treatment of cellulitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 23, 2020 Category: Dermatology Source Type: research

Validation of Psychometric Properties of the Itch Numeric Rating Scale for Pruritus
This randomized, double-blind study evaluates the psychometric properties of the itch numeric rating scale for measuring severity of pruritis associated with prurigo nodularis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 16, 2020 Category: Dermatology Source Type: research

New Primary Melanoma After Treatment With Immune Checkpoint Inhibitors
This observational cohort study assesses the incidence of new cutaneous melanoma in patients treated with ipilimumab, nivolumab, and/or pembrolizumab for metastatic melanoma. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 16, 2020 Category: Dermatology Source Type: research

Pigmented Plaque in the Axilla
A woman in her 70s presented with an enlarged and variegated plaque on her left axilla that was asymptomatic and slow growing. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 16, 2020 Category: Dermatology Source Type: research

Association of Clinical and Demographic Factors With the Severity of Palmoplantar Pustulosis
This cross-sectional study examines factors that may contribute to the severity of symptoms in patients with palmoplantar pustulosis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 16, 2020 Category: Dermatology Source Type: research

Pigmented Fungiform Papillae of the Tongue
This case report describes scattered hyperpigmented spots on the tongue of an adolescent girl. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 9, 2020 Category: Dermatology Source Type: research

Evaluating Areas of Preferred Hair Loss
This survey study seeks to assess whether there is a preference for location of hair loss on the scalp. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 9, 2020 Category: Dermatology Source Type: research

Early Severe Cardiovascular Events and the Initiation of Ustekinumab
This case-time-control analysis uses data from the French national health insurance database to assess whether the initiation of ustekinumab treatment is associated with triggering severe cardiovascular events. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 9, 2020 Category: Dermatology Source Type: research

Indoor Tanning 5 Years After Youth Access Restrictions
This survey study examines the prevalence and location of indoor tanning among New Jersey youths after a 2013 statewide indoor tanning ban for minors younger than 17 years. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 2, 2020 Category: Dermatology Source Type: research

Suction Blisters
This case report describes linear bullae on the dorsal aspect of all fingers and thumb on the left hand of a female infant. and a single blister on the left forearm. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 2, 2020 Category: Dermatology Source Type: research

Clinical Characteristics of Lupus Erythematosus Panniculitis/Profundus
This case series characterizes the initial presentation and treatment of lupus erythematosus panniculitis/profundus and its association with systemic lupus erythematosus and discoid lupus erythematosus. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 2, 2020 Category: Dermatology Source Type: research

Association of the Psoriatic Microenvironment With Treatment Response
This study examines a novel decision analytical model designed to measure mRNA gene expression changes to define the psoriatic microenvironment and assess medication response before a change in the Psoriasis Area and Severity Index score is evident. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 2, 2020 Category: Dermatology Source Type: research

Association Between Drug Use and Subsequent Diagnosis of Lupus Erythematosus
This case-control study examines the association between drug use and a subsequent diagnosis of subacute cutaneous lupus erythematosus or systemic lupus erythematosus based on a systematic screening process of the drugs in the Anatomical Therapeutic Chemical classification system in a nationwide setting. (Source: JAMA Dermatology)
Source: JAMA Dermatology - September 2, 2020 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement: JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, der...
Source: JAMA Dermatology - September 1, 2020 Category: Dermatology Source Type: research

Edematous and Ulcerative Eruption With Nasolabial Sparing in an Older Woman
A woman in her 70s presented with painless, rapidly progressive, edematous, necrotic papules and plaques on the extremities, buttocks, and face. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

Error in Author Name
In the Letter to the Editor titled “Evaluation of the Merits and Limitations of Evidence-Based Medicine,” published online first on June 24, 2020, and in the August 2020 print issue of JAMA Dermatology, the last author’s name incorrectly included a middle initial. The author’s correct name is Daniela Kroshinsky, MD, MPH. The article has been corrected. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

Special Consideration for Patients With Morgellons Disease, Even Among Psychodermatology Patients?
To the Editor We read with great interest the article on psychodermatology recently published by Patel and Jafferany along with the Editorial by Magid and Reichenberg. We applaud the authors for highlighting such an important topic and adding to scarce literature on structural aspects and models of care in psychocutaneous medicine. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

TEMPI Syndrome With Progressive Telangiectasias Associated With Pulmonary Deterioration
This case report describes a 50-year-old man with dyspnea, an oxygen saturation of 90% to 92% with clubbing, and scattered telangiectasias on his chest. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

Special Consideration for Patients With Morgellons Disease, Even Among Psychodermatology Patients? —Reply
In Reply We thank Brownstone and Koo for their interest and response to our systematic review reporting on models of care for patients with psychocutaneous conditions and acknowledgment of the subpopulation of patients with Morgellons disease. Within our article, we report patients with a diagnosis of delusions of parasitosis (DoP) to represent the largest proportion among all included individuals with various psychodermatologic conditions. Because of the complex, growing, and difficult-to-manage nature of Morgellons disease, increased awareness and special considerations are called for while treating affected patients. (S...
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

Administrative Burden and Costs of Prior Authorizations in a Dermatology Department
This cross-sectional study examines the administrative burden and costs of prior authorizations in a large academic dermatology department over a 30-day period. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

Ratio of Basal Cell to Cutaneous Squamous Cell Carcinomas in the United States
This cross-sectional study defines differences in the ratio of basal cell to cutaneous squamous cell carcinomas in US adults in a large database of patients with commercial insurance and Medicare Advantage coverage. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 26, 2020 Category: Dermatology Source Type: research

Concentric Annular Truncal Eruption
A man in his 60s presents with intermittently pruritic, red scaling plaques in a concentric pattern diffusely involving the chest, back, and abdomen. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 19, 2020 Category: Dermatology Source Type: research

Dermatology ’s Management of Flagship Diseases in Older Adults
This is an ideal time to discuss the vulnerabilities of our older generations. The COVID-19 pandemic has illuminated how disease can have unique and detrimental effects on older adults, including atypical presentation, rapid disease progression, and higher mortality rates. This vulnerability has always existed, but this crisis has highlighted to the medical community and the general population that meeting the needs of this group requires unique effort, approach, and understanding. Dermatology has struggled to capture these unique vulnerabilities in education and research of even our most common diseases. This creates the ...
Source: JAMA Dermatology - August 19, 2020 Category: Dermatology Source Type: research

Vaccination Against Human Papillomavirus
This clinical evidence synopsis summarizes the findings of 21 human papillomavirus vaccination trials published from 2000 to 2019. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 19, 2020 Category: Dermatology Source Type: research

Effectiveness and Safety of Systemic Therapy for Psoriasis in Older Adults
This systematic review evaluates the effectiveness and safety of systemic antipsoriatic therapies in patients 65 years or older. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 19, 2020 Category: Dermatology Source Type: research

Inclusion of Older Adults in RCTs for Systemic Medication in the Treatment of Atopic Dermatitis
This systematic review uses data from randomized clinical trials obtained via MEDLINE, Embase, Cochrane Central Register, and ClinicalTrials.gov to investigate the inclusion of older adults in studies pertaining to systemic medication used in the treatment of atopic dermatitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 19, 2020 Category: Dermatology Source Type: research

Topical Calcineurin Inhibitors and Skin Cancer
For most people with atopic dermatitis, management of their skin disease includes years of continuous or intermittent use of topical medications. Counseling on that element of chronic disease management is a crucial part of physician visits for patients with atopic dermatitis. Inevitably, discussions about the long-term safety of patients ’ treatment plans are included and these discussions are usually based on little long-term evidence. Randomized clinical trials are often underpowered and too short to detect long-term, rare adverse events. Those clinical discussions became more nuanced with the introduction of the ...
Source: JAMA Dermatology - August 12, 2020 Category: Dermatology Source Type: research

Darier Disease
This case report describes a patient with pruritic rash, white and red streaks and V-shaped notching of the fingernails, yellow-brown greasy papules on the thighs and chest, and small white papules on the oral gingivae coalescing into cobblestoned plaques. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 12, 2020 Category: Dermatology Source Type: research

Deep Learning Algorithms for Measurement of Hair Loss in Patients With Alopecia Areata
This study aims to develop a deep learning framework to determine the Severity of Alopecia Tool (SALT) score for measurement of hair loss in patients with alopecia areata. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 12, 2020 Category: Dermatology Source Type: research

Trends in List and Net Price of Psoriasis Therapies From US Pharmaceutical Companies
This economic evaluation reviews the trends in list and net price data from SSR Health for the 2007 to 2019 period of self-administered systemic psoriasis medications manufactured in the United States. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 12, 2020 Category: Dermatology Source Type: research

Association Between Topical Calcineurin Inhibitor Use and Risk for Keratinocyte Carcinoma
This cohort study examines the risk of keratinocyte carcinoma in adults with atopic dermatitis who receive topical calcineurin inhibitors. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 12, 2020 Category: Dermatology Source Type: research

Melanosis of the Vulva
This case series evaluates the clinical and dermoscopic features of vulvar melanosis and their changes over time. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 12, 2020 Category: Dermatology Source Type: research

ABCB1 Gene Variants and Persistent Chemotherapy-Induced Alopecia
This genetic association study explores whether an association exists between genetic factors and the development of persistent chemotherapy-induced alopecia in women with breast cancer who are treated with docetaxel. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 5, 2020 Category: Dermatology Source Type: research

Erythematous Nodule With Central Crust on the Nail Fold in an Infant
A girl younger than 2 years presented with a 7-month history of an inflammatory plaque with a central shiny orange crust on her left index finger and no improvement with empiric therapy. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 5, 2020 Category: Dermatology Source Type: research

Insights Into the Biology of Persistent Chemotherapy-Induced Alopecia via Genomic Approaches
A major concern among patients with cancer is hair loss secondary to chemotherapy, an adverse effect that occurs among approximately 65% of patients who undergo this form of therapy. The association between chemotherapy and hair loss is well known across society, and chemotherapy-induced alopecia (CIA) can, therefore, induce a sense of violated privacy, or even shame, among those affected. The association of this adverse effect with reduced self-esteem, social confidence, and sexuality is particularly devastating for women. The anticipation of CIA is so distressing that some female patients even seriously consider refusing...
Source: JAMA Dermatology - August 5, 2020 Category: Dermatology Source Type: research

Livedoid and Purpuric Skin Eruptions Associated With Coagulopathy in Severe COVID-19
This case series describes livedo racemosa and retiform purpura as cutaneous findings in patients with COVID-19. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 5, 2020 Category: Dermatology Source Type: research

Assessment and Treatment Outcomes of Persistent Radiation-Induced Alopecia in Patients With Cancer
This cohort study examines the characteristics and management of persistent radiation-induced alopecia in patients with primary central nervous system tumors or head and neck sarcomas. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 5, 2020 Category: Dermatology Source Type: research

Mitigation Strategies for Physician Burnout Among Dermatologists
This Viewpoint highlights 4 strategies to combat physician burnout among dermatologists. (Source: JAMA Dermatology)
Source: JAMA Dermatology - August 5, 2020 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement: JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, der...
Source: JAMA Dermatology - August 1, 2020 Category: Dermatology Source Type: research

Prognostic Gene Expression Profiling in Cutaneous Melanoma
This consensus statement assesses what evidence is needed to develop guidelines on integration of gene expression profile testing into cutaneous melanoma management. (Source: JAMA Dermatology)
Source: JAMA Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Consensus, Controversy, and Conversations About Gene Expression Profiling in Melanoma
Personalized medicine, which is clinical management tailored to the individual patient, is gaining increased attention in every specialty. Gene expression profiling (GEP) measures the levels of multiple genes in an individual ’s tumor and predicts a clinical outcome (eg, melanoma recurrence) based on advanced machine learning and artificial intelligence algorithms. Although not yet endorsed by the American Academy of Dermatology or the National Comprehensive Cancer Network, the use of GEP is increasing, with approximat ely 12 000 DecisionDx-Melanoma tests processed per year. As GEP tests penetrate the dermatology m...
Source: JAMA Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Bart-Pumphrey Syndrome
This case report describes a young man with Bart-Pumphrey syndrome, a rare genetic disorder affecting both the skin of the hands and the hearing. (Source: JAMA Dermatology)
Source: JAMA Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Increased Risk of Sensorineural Hearing Loss in Patients With Alopecia Areata
This nationwide population-based cohort study investigates the risk of hearing loss in patients with alopecia areata using claims data from the National Health Insurance Research Database in Taiwan. (Source: JAMA Dermatology)
Source: JAMA Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Performance of Gene Expression Profile Tests for Prognosis of Localized Cutaneous Melanoma
This systematic review and meta-analysis assesses the performance of commercially available gene expression profile tests for prognosis of cutaneous melanoma in patients with stage I or stage II melanoma (Source: JAMA Dermatology)
Source: JAMA Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Central Centrifugal Cicatricial Alopecia
This Patient Page describes the symptoms, possible causes, and treatment of central centrifugal cicatricial alopecia. (Source: JAMA Dermatology)
Source: JAMA Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Error in Results Section
The Brief Report titled “An Intrapatient Concordance Study of Mismatch Repair Protein Immunohistochemical Staining Patterns in Patients With Muir-Torre Syndrome,” published in the June 2020 print issue of JAMA Dermatology, included an error in the Results section. In the sentence that reads “A total of 38 specimens ( 28 sebaceous adenoma, 4 sebaceous endothelioma, and 6 unclassifiable SN),” “endothelioma” should be “epithelioma.” This has been corrected. (Source: JAMA Dermatology)
Source: JAMA Dermatology - July 22, 2020 Category: Dermatology Source Type: research