Characteristics of Patients With Psoriasis Associated With “Not Relevant” Responses on the DLQI
This cross-sectional study using data from the Dermatology Clinical Effectiveness Research Network assesses whether the frequency of “not relevant” responses on the Dermatology Life Quality Index (DLQI) is associated with sociodemographic characteristics of patients with psoriasis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 26, 2020 Category: Dermatology Source Type: research

Challenges in Understanding, Scoring, and Comparing Patients ’ Reports
Outcomes researchers who work with patients ’ reports (often called patient-reported outcomes, or PROs) are accustomed to skepticism. For example, although the measurement of PROs is based on decades of quantitative social science research, other scientists may doubt that patients’ reports can be measured accurately. Similarly, quantitati ve scores of PRO tools are often unfamiliar, and clinicians may question whether PROs are useful to inform decision-making or improve care. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 26, 2020 Category: Dermatology Source Type: research

Dermoscopy of Uncommon Melanoma Variants
The article by Pampena et al describes 10 rare melanoma variants. Their systematic review highlights the challenging nature of diagnosing melanomas with atypical clinical and dermoscopic features, with a wide differential diagnosis that often includes nonmelanocytic tumors and inflammatory conditions. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 26, 2020 Category: Dermatology Source Type: research

Current Status of Dermatologic Education in US Medical Schools
This survey study assesses the status and content of dermatology curricula in US medical schools accredited by the Liaison Committee on Medical Education. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 26, 2020 Category: Dermatology Source Type: research

Efficacy and Safety of Lebrikizumab in Adults With Moderate to Severe Atopic Dermatitis
This phase 2b, placebo-controlled, randomized clinical trial evaluates the efficacy and safety of lebrikizumab, a novel, high-affinity, monoclonal antibody targeting interleukin (IL) –13 that selectively prevents formation of the IL-13Rα1/IL-4Rα heterodimer receptor signaling complex, in adults with moderate to severe atopic dermatitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 26, 2020 Category: Dermatology Source Type: research

Clinical and Dermoscopic Features of Difficult-to-Recognize Variants of Cutaneous Melanoma
This systematic review describes the key clinical and dermoscopic features of the most frequently reported yet uncommon histologic variants of cutaneous melanoma to provide differential criteria for diagnosing these variants among other benign or malignant skin lesions. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 26, 2020 Category: Dermatology Source Type: research

Rapidly Evolving Necrotic Plaques and Nodules in a Middle-aged Woman
A woman in her 50s presented with scaly erythematous patches and plaques, epidermotropic infiltrate of CD3+, CD4 −, and CD8− weak lymphocytes, and expanding ulcerated tumors. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 19, 2020 Category: Dermatology Source Type: research

Unilateral Septic Emboli From an Infected Pseudoaneurysm
This case report describes a man in his 60s with unilateral septic emboli and pseudoaneurysm. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 19, 2020 Category: Dermatology Source Type: research

Participation and Performance of Dermatologists in the 2017 Merit-Based Incentive Payment System
This cross-sectional study explores participation in the Merit-Based Incentive Payment System by dermatologists, including those who would benefit from resources to enhance engagement and performance. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 19, 2020 Category: Dermatology Source Type: research

Onabotulinum Toxin A for Sacral and Intergluteal Cleft Hyperhidrosis
This case report describes a 31-year-old man with a 1-month history of hyperhidrosis of the buttocks, most severe at the intergluteal cleft and sacrum. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 19, 2020 Category: Dermatology Source Type: research

Association of Indoor Tanning Regulations With Health and Economic Outcomes in North America and Europe
This economic analysis estimates the long-term association of banning indoor tanning devices or prohibiting their use by minors only with health and economic outcomes in North America and Europe. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 19, 2020 Category: Dermatology Source Type: research

Prevalence, Incidence, and Risk of Cancer in Patients With Psoriasis and Psoriatic Arthritis
This systematic review and meta-analysis evaluates the association between cancer and psoriasis or psoriatic arthritis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 19, 2020 Category: Dermatology Source Type: research

Association Between Sexual Orientation and Lifetime Prevalence of Skin Cancer in the United States
This cross-sectional study examines the association between sexual orientation and self-reported lifetime prevalence of skin cancer in the United States among individuals who have self-identified as being heterosexual or of a sexual minority population. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Treatment of Childhood-Onset Lupus Erythematosus Panniculitis With Rituximab
This case series describes the clinical features of childhood-onset lupus erythematosus panniculitis and reports on the use of rituximab for patients with treatment-refractory, childhood-onset disease. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

A Treatment-Refractory, Perianal Tumor Arising in an Otherwise Healthy Older Adult Woman
A woman in her 80s presented with a growing, painful tumor on her buttock with epithelial hyperplasia, ulceration, focal multinucleated keratinocytes, and herpes simplex virus positivity. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Sexual and Gender Minority Populations and Skin Cancer
Sexual and gender minority (SGM) persons include, but are not limited to, individuals who identify as lesbian, gay, bisexual, or transgender, as well as individuals whose sexual orientation, gender identity or expression, or reproductive development are characterized by nonbinary constructs of sexual orientation, gender, and/or sex. The National Cancer Institute (NCI) has called for specific research to “assess cancer risk to inform improved decision-making, risk reduction interventions, and screening options for early cancer detection in SGM populations.” Notably, population-based data on skin cancer epidemiol...
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Association of Gender Identity With Lifetime Prevalence of Skin Cancer in the United States
This cross-sectional study uses Behavioral Risk Factor Surveillance System data to examine the association of gender identity with self-reported lifetime prevalence of skin cancer. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Quality of Life in Patients With Skin of Color and Chronic Graft-vs-Host Disease
This survey study explores the scope of chronic graft-vs-host disease among a cohort of patients with skin of color. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Application of Basic Epidemiologic Principles and Electronic Health Records in a Deep Learning Prediction Model
To the Editor We read with great interest the article by Wang et al. In their study, the authors applied deep learning techniques to predict 1-year risk of nonmelanoma skin cancer from clinical diagnostic information and medical records, including medication received. Their model showed an area under the receiver operating characteristic curve of 0.89 (95% CI, 0.87-0.91), which is impressive accuracy. However, the study may have important flaws in its design that are likely to have biased upward the estimation of the model ’s accuracy. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Application of Basic Epidemiologic Principles and Electronic Health Records in a Deep Learning Prediction Model
To the Editor We found the study by Wang et al to be an interesting read. It raises important issues regarding the data-driven approach in the field of dermatology, and some obstacles should be discussed before applying it clinically. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Application of Basic Epidemiologic Principles and Electronic Health Records in a Deep Learning Prediction Model —Reply
In Reply In our recently published study, we developed a risk prediction model without information on UV exposure or lesional character to predict new-onset nonmelanoma skin cancer in an Asian population. A deep learning convolutional neural network was created using nonimaging diagnostic and medication information to predict nonmelanoma skin cancer. The optimal area under the curve was 0.89. However, owing to random sampling, the group with skin cancer and the control group were not age matched. We agree that age was a dominating factor, but it might not be the most important one. By further building age and gender-matche...
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis
This noninferiority randomized clinical trial investigates whether dose reduction of biologics for stable psoriasis is noninferior to usual care in patients with plaque psoriasis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 12, 2020 Category: Dermatology Source Type: research

Comparative Effectiveness Studies for Psoriasis —The Methods Matter
Over the past 15 years, many new treatments for psoriasis have been developed that achieve better, more rapid, and durable efficacy. The availability of these psoriasis therapies is valuable to both patients and clinicians and offers more options for shared decision making. However, solely relying on the registrational clinical trials that demonstrate the efficacy of these drugs does not allow a full understanding of the relative effect of these medicines weighed against each other. The challenge for the clinician is to go beyond the absolute efficacy of medications to an understanding of their comparative merit and then i...
Source: JAMA Dermatology - February 5, 2020 Category: Dermatology Source Type: research

Gardenia Fruit –Related Blue-Gray Skin Pigmentation
This case report describes a 77-year-old woman with a 7-year history of oral shishihakuhito treatment, which is mainly composed of gardenia fruit, presenting with blue-gray skin pigmentation. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 5, 2020 Category: Dermatology Source Type: research

Comparison of Biologics and Oral Treatments for Plaque Psoriasis
This meta-analysis examines the use of biologics and oral agents for treatment of moderate to severe psoriasis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 5, 2020 Category: Dermatology Source Type: research

Association of Race/Ethnicity and Sex With Differences in Health Care Use and Treatment for Acne
This cohort study of patients with acne evaluates the association of patients ’ race/ethnicity and sex with health care use and specific treatments for acne. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 5, 2020 Category: Dermatology Source Type: research

Comparison of Psoriasis Severity in Pediatric Patients Receiving Methotrexate vs Biologic Agents
This cohort study compares the use of methotrexate vs biologic agents in children with moderate to severe psoriasis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - February 5, 2020 Category: Dermatology Source Type: research

February 2020 Issue Highlights
(Source: JAMA Dermatology)
Source: JAMA Dermatology - February 1, 2020 Category: Dermatology Source Type: research

JAMA Dermatology
Mission Statement: JAMA Dermatology publishes information concerning the skin, its diseases, and their treatment. Its mission is to explicate the structure and function of the skin and its diseases and the art of using this information to deliver optimal medical and surgical care to the patient. We attempt to enhance the understanding of cutaneous pathophysiology and improve the clinician ’s ability to diagnose and treat skin disorders. This journal has a particular interest in publishing clinical and laboratory studies that reveal new information pertinent to the interests and needs of the medical dermatologist, der...
Source: JAMA Dermatology - February 1, 2020 Category: Dermatology Source Type: research

Health-Related Quality of Life in Solid Organ Transplant Recipients With vs Without Keratinocyte Carcinoma
This cross-sectional study compares health-related quality of life between solid organ transplant recipients with vs without keratinocyte carcinoma using the Basal and Squamous Cell Carcinoma Quality of Life questionnaire and the Short Form 36 Health Survey. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 30, 2020 Category: Dermatology Source Type: research

Dermatopathologists ’ Experience With and Perceptions of Patient Access to Pathologic Test Reports
This survey study examines the perspectives of dermatopathologists regarding patients ’ online access to reports on the results of pathologic tests. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

Transparency in Patient Access to Dermatopathologic Reports
“Information wants to be free.” This adage, attributed to Stewart Brand, has often been invoked in the internet era to suggest that, as logistical barriers to access come down, individuals should have free access to all types of information, in any manner of their choosing. Unfettered access to data, music, education, and other services has been the guiding principle and promise of the electronically connected modern world. However, the actual costs of “free” information have gradually become apparent, such as the data mining and surveillance of individuals used to finance internet sea rch and socia...
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

Patient Ability to Interpret Dermatopathology Reports in an Academic Dermatology Practice
This survey study assesses patients ’ ability to interpret a dermatopathology report. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

Complementary and Alternative Medicine Use in Patients With Hidradenitis Suppurativa
This survey study examines the use and perceptions of complementary and alternative medicine by individuals with hidradenitis suppurativa who completed an anonymous survey. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

Treatment of Netherton Syndrome with Dupilumab
This case report describes a 32-year-old woman with Netherton syndrome, which caused polycyclic serpiginous, erythematous plaques with double-edged scale on her trunk and extremities. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

Multidimensional Acne Global Grading System Integrating Primary Lesions and Secondary Changes
This diagnostic study develops and validates an acne global grading system that evaluates primary lesions and secondary changes due to acne in patients 21 years or younger. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

Lymphomatoid Papulosis
This Patient Page describes signs and symptoms of lymphomatoid papulosis, how it is diagnosed, and methods of treatment. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 29, 2020 Category: Dermatology Source Type: research

A Solitary Umbilical Nodule
A woman in her 40s with no significant medical history presented with a 1-year history of an umbilical nodule; she described occasional pain and intermittent bleeding from the site. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 22, 2020 Category: Dermatology Source Type: research

Clinical Characteristics and Medical Management of Idiopathic Granulomatous Mastitis
This case series reports the clinical presentation and course of treatment for 32 women with biopsy-proven idiopathic granulomatous mastitis. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 22, 2020 Category: Dermatology Source Type: research

Risk of Inflammatory Arthritis After a New Diagnosis of Hidradenitis Suppurativa
This cohort study evaluates the risk of developing inflammatory arthritis among patients with hidradenitis suppurativa. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 22, 2020 Category: Dermatology Source Type: research

Clinical Markers of Vitiligo and Progression Among Chinese Patients
This cohort study evaluates the utility of clinical markers of vitiligo, such as trichrome sign, confetti-like depigmentation, and Koebner phenomenon, in assessing disease progression, severity, and prognosis in patients from China. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 22, 2020 Category: Dermatology Source Type: research

Core Outcome Set for Actinic Keratosis Clinical Trials
This survey study assesses the most important outcomes to report in clinical trials on actinic keratosis based on Delphi surveys completed by physician and patient stakeholders. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 15, 2020 Category: Dermatology Source Type: research

A Step Toward Standardizing Clinical Trials of Actinic Keratosis
The practice of medicine was revolutionized in 1992 with the introduction of the concept of evidence-based medicine. Since the advent of this movement, systematic reviews and meta-analyses not only have become popular but also have steered the development of clinical practice guidelines and supported justification of further research by granting agencies. By summarizing available data and comparing the effectiveness of multiple treatment alternatives, systematic reviews provide a high level of evidence quality on the clinical benefits and harms of interventions, which is highly desired in health care decision-making. Howev...
Source: JAMA Dermatology - January 15, 2020 Category: Dermatology Source Type: research

Jellyfish Sting —In Vivo Imaging for Diagnosis and Treatment Monitoring
This case report describes a woman in her 30s with a jellyfish sting on her right wrist, which caused erythematous serpiginous plaques with superficial scaling in a braceletlike shape. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 15, 2020 Category: Dermatology Source Type: research

Cross-Sectional Study, Systematic Review, and Proposed Diagnostic Criteria of Necrobiotic Xanthogranuloma
This study combines a multicenter cohort study with a systematic review and a consensus-based expert review to evaluate the characteristics of necrobiotic xanthogranuloma and propose diagnostic criteria for this disease. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 15, 2020 Category: Dermatology Source Type: research

A Translucent Nodule of the Nipple in an Elderly Male Patient
A male patient in his 70s presents with an asymptomatic, slightly eroded, translucent nodule on his right nipple. What is your diagnosis? (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 8, 2020 Category: Dermatology Source Type: research

100th Anniversary of JAMA Dermatology as a Publication of the American Medical Association
One hundred years ago, the American Medical Association became the publisher of The Journal of Cutaneous Diseases and changed the journal ’s name to Archives of Dermatology and Syphilology to align with the titles of other medical journals published by the organization. Close reading of the announcement (BoxBox) of this change makes us proud to be Editor of JAMA Dermatology (K.S.) and Editor in Chief of JAMA and the JAMA Network (H. B.) at this most auspicious time for JAMA Dermatology and also inspires important reflections of where the journal has been, where it stands currently, and where it is going. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 8, 2020 Category: Dermatology Source Type: research

Mikulicz Disease
This case report describes a man in his 60s with a history of bilateral swelling of the upper and lower eyelids. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 8, 2020 Category: Dermatology Source Type: research

Creation of a Registry to Address Knowledge Gaps in Hidradenitis Suppurativa and Pregnancy
To the Editor We read with interest the Editorial by Naik and Lowes and agree that there is an urgent need to advance knowledge in hidradenitis suppurativa (HS). We wish to highlight a particularly vulnerable but overlooked population with HS: those who are pregnant or seeking to become pregnant. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 8, 2020 Category: Dermatology Source Type: research

Creation of a Registry to Address Knowledge Gaps in Hidradenitis Suppurativa and Pregnancy —Reply
In Reply We thank Adelekun and colleagues for their response to our Editorial calling for accelerated hidradenitis suppurativa (HS) research and improved care of patients with HS. We wholeheartedly agree that more evidence about the effects of HS on fertility, pregnancy, maternal and fetal outcomes, and lactation is needed to help guide optimal care of patients with HS who are of childbearing potential. (Source: JAMA Dermatology)
Source: JAMA Dermatology - January 8, 2020 Category: Dermatology Source Type: research