Comparison of Intralesional Sodium Stibogluconate versus Intralesional Meglumine Antimoniate for the Treatment of Leishmania major Cutaneous Leishmaniasis
In conclusion, the 2 different medications have the same efficacy and safety for treating cutaneous leishmaniasis. Pentavalent antimoniate intralesional infiltration treatment is safe, effective, and well tolerated with minimal side effects for Old-World cutaneous leishmaniasis.PMID:38682801 | DOI:10.2340/actadv.v104.35089 (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - April 29, 2024 Category: Dermatology Authors: Michal Solomon Ayelet Ollech Felix Pavlotsky Aviv Barzilai Eli Schwartz Sharon Baum Nadav Astman Source Type: research
miRSNP rs188493331: A key player in genetic control of microRNA-induced pathway activation in hypertrophic scars and keloids
CONCLUSIONS: The study successfully unveils the complex interactions between miRSNPs, miRNAs, genes, and signaling pathways, shedding light on the genetic factors contributing to HS and keloid formation.PMID:38682767 | DOI:10.1111/srt.13686 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Meiqing Chen Yuyan Pan Zhiwei Chen Fazhi Qi Jianying Gu Yangyang Qiu Anqi He Jiaqi Liu Source Type: research
A piezoelectric-driven microneedle platform for skin disease therapy
Innovation (Camb). 2024 Apr 5;5(3):100621. doi: 10.1016/j.xinn.2024.100621. eCollection 2024 May 6.ABSTRACTWith over a million cases detected each year, skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate, propensity for recurrence, and potential for post-treatment scarring. Photodynamic therapy (PDT) is a treatment with minimal invasiveness or scarring and few side effects, making it well tolerated by patients. However, this treatment requires further research and development to improve its effective clinical use. Here, a piezoelectric-driven microneedle (P...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Ziyan Chen Xin Liu Zixi Jiang Huayi Wu Tao Yang Lanyuan Peng Lisha Wu Zhongling Luo Mi Zhang Juan Su Yan Tang Jinmao Li Yang Xie Han Shan Qibo Lin Xiuli Wang Xiang Chen Hanmin Peng Shuang Zhao Zeyu Chen Source Type: research
Role of Insulin Use and Social Determinants of Health on Non-melanoma Skin Cancer: Results From the Behavioral Risk Factor Surveillance System
CONCLUSIONS: Our findings suggest that socioeconomic differences related to the healthcare system and behavioral patterns are linked to discrepancies in the use of insulin and the development of NMSC.PMID:38680117 | DOI:10.1177/10732748241249896 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nour Massouh Ayad A Jaffa Miran A Jaffa Source Type: research
A reinterpretation of human breast anatomy includes all the layers of the anterior body wall
Anat Rec (Hoboken). 2024 Apr 29. doi: 10.1002/ar.25456. Online ahead of print.ABSTRACTMammary glands define mammals as a group, yet a comprehensive anatomical description of the mammary gland does not exist for almost any mammalian species. In humans, the anatomical and surgical literature provide conflicting and incomplete descriptions of the gross anatomy of the breast. We dissected 9 male and 15 female human body donors to clarify this gross anatomy. We found that, like other epidermally derived glands of the body, the mammary glandular tissue is constrained to a membrane-bound, central structure referred to as the corp...
Source: Anatomical Record - April 29, 2024 Category: Anatomy Authors: Margaret I Hall Ana Suarez-Venot Tyler Lindvall Jeffrey H Plochocki Aryeh Grossman Jose R Rodriguez-Sosa Georgina M Voegele Dominik R Valdez Justin A Georgi Source Type: research
A new mechanism in negative pressure wound therapy: interleukin-17 alters chromatin accessibility profiling
In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting re-epithelialization, extracellular matrix (ECM) synthesis and prol...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Shuao Xiao Wenxuan Wang Congying Zhao Pan Ren Liwei Dong Hao Zhang Fuxin Ma Xueyong Li Yongqian Bian Source Type: research
A new mechanism in negative pressure wound therapy: interleukin-17 alters chromatin accessibility profiling
In this study, skin wound-healing models were established, with administration of NPWT. Vimentin, collagen I, and MMP9 of skin tissues were detected by immunofluorescence (IF). Gene expression analysis of skin wound tissues was performed by RNA-sequencing (RNA-seq). Protein expression was assayed by a western blotting or IF assay, and mRNA levels were quantified by quantitative PCR. Chromatin accessibility profiles of fibroblasts following NPWT or IL-17 exposure were analyzed by ATAC-seq. In rat wound-healing models, NPWT promoted wound repair by promoting re-epithelialization, extracellular matrix (ECM) synthesis and prol...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Shuao Xiao Wenxuan Wang Congying Zhao Pan Ren Liwei Dong Hao Zhang Fuxin Ma Xueyong Li Yongqian Bian Source Type: research
Enhancing effects of < em > Aloe vera < /em > gel extracts on the humoral and cellular immune response and growth performance in broiler chickens
CONCLUSION: This work strengthens the perspective of the use of AVG as an immune stimulant to facilitate recovery from immune suppression states, enhance innate and specific immunity, and improve broiler growth performance.PMID:38680801 | PMC:PMC11055579 | DOI:10.5455/javar.2024.k745 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Mohammad Alam Miah Snigda Akter Md Saif Uddin Khaled Mahmud Sujan Afrina Mustari Sharmin Akter Source Type: research
Safety Profile of Upadacitinib up to 5 Years in Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis: An Integrated Analysis of Clinical Trials
ConclusionHigher rates of serious infection, HZ, lymphopenia, and NMSC were observed with upadacitinib versus adalimumab in PsA; slightly elevated rates for most of these TEAEs were seen with upadacitinib in PsA versus axSpA. Upadacitinib 15 mg demonstrated a generally consistent safety profile across disease states with no new safety signals identified.Trial RegistrationSELECT-AXIS 1: NCT03178487; SELECT-AXIS 2: NCT04169373; SELECT-PsA 1: NCT03104400; SELECT-PsA 2: NCT03104374. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - April 29, 2024 Category: Rheumatology Source Type: research
Bruton ’s Tyrosine Kinase Inhibition in Pemphigus: An Embattled Frontier
In their recent article in the Journal, Murrell et al., 2024 report the results of the pivotal clinical trial of rilzabrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, for the treatment of moderate-to-severe pemphigus. The study did not meet its primary endpoint. In this paper, we briefly examine the biologic rationale and clinical applicati on of BTK inhibitors to pemphigus specifically and B-cell–mediated autoimmune diseases more broadly to inform future studies in the field. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 29, 2024 Category: Dermatology Authors: Aimee S. Payne, Silvio Manfredo Vieira Tags: Commentary Source Type: research
The Ethics of Full Body Skin Exams (FBSE)
Full body skin examinations (FBSEs) are part of the purview of a dermatologic exam. Because this involves examination of sensitive or “intimate” areas, there are many ethical issues involved. Herein we discuss whether screening patients with a FBSE is ethical and consistent with the ethical tenet of distributive justice, how to ethically deal with our disabled patients, how to ethically navigate patients who have been emotiona lly or physically traumatized in the past, and the ethical ramifications of the use of a chaperone. (Source: Clinics in Dermatology)
Source: Clinics in Dermatology - April 29, 2024 Category: Dermatology Authors: Jane M. Grant-Kels Tags: Ethics of Total Body Examination Source Type: research
Progress towards elimination of onchocerciasis in the < i > Region du Sud-Ouest < /i > of Burkina Faso which was previously subject to a recrudescence event after vector control
Conclusions/significanceThe endemicity of onchocerciasis infection in theSud-Ouest region has declined to low levels and seems to be progressing towards elimination. Our findings indicated that biannual CDTI is having good effect, but it should continue for a number of years to ensure elimination of transmission. However, progress towards elimination has a troublesome history in this region, and it would be advisable to select more sentinel villages to have confidence in any future epidemiological and entomological surveys, especially Stop-MDA surveys. With positive individuals migrating between countries, cross-border col...
Source: PLoS Neglected Tropical Diseases - April 29, 2024 Category: Tropical Medicine Authors: Achille Sindimbasba Niki èma Source Type: research
Stigma experiences, effects and coping among individuals affected by Buruli ulcer and yaws in Ghana
Conclusions and significanceThe types and levels of stigma varied for BU and yaws. Stigma experiences also differed for adults and children in this setting and these differences should be accounted for in integrated interventions for these skin NTDs. School health programs need to prioritize educating school teachers about skin NTDs and the negative impact of stigma on the wellbeing of children. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 29, 2024 Category: Tropical Medicine Authors: Ruth Dede Tuwor Source Type: research
Driving Diversity in Dermatology
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 29, 2024 Category: Dermatology Authors: Korena Boyd Tags: Letter: Notes & Comments Source Type: research
Pre-operative and intra-operative dermoscopy of nail unit squamous cell carcinoma and its relationship with the depth of invasion: a retrospective study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 29, 2024 Category: Dermatology Authors: Ji Su Lee, Je-Ho Mun Source Type: research
