Significance of Macrophage Subtypes in the Peripheral Blood of Children with Systemic Juvenile Idiopathic Arthritis
This study aimed to explore macrophage subtypes in different stages of sJIA.MethodsTwenty-two children with sJIA who were followed up at Shanghai Children ’s Hospital from January 2018 to December 2020 were enrolled in this study. sJIA children were divided into an activity group (n = 12) and an inactivity group (n = 10). In the activity group, subjects with newly diagnosed sJIA and untreated were included; in the inactivity group, subjects with inactive sJIA meeting the 2011 ACR criteria for sJIA were recruited. Ten children with orthostatic proteinuria served as controls. Peripheral bloo...
Source: Rheumatology and Therapy - October 25, 2021 Category: Rheumatology Source Type: research

Clinical Characteristics of Psoriatic Arthritis in Chinese Patients: A Cross-Sectional Study
ConclusionsPolyarticular involvement was most common in Chinese PsA patients. Ultrasound dramatically increased the identification of peripheral enthesitis. Active PsA patients were more likely to have comorbidities. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 19, 2021 Category: Rheumatology Source Type: research

Patient-Reported Outcomes in Psoriatic Arthritis Patients with an Inadequate Response to Biologic Disease-Modifying Antirheumatic Drugs: SELECT-PsA 2
ConclusionsUpadacitinib provides rapid, clinically meaningful, and sustained improvements in PROs reported by bDMARD-IR PsA patients. SELECT-PsA 2 ClinicalTrials.gov number, NCT03104374. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 18, 2021 Category: Rheumatology Source Type: research

Ultrasound Effectiveness of Steroid Injection for hand Psoriatic Dactylitis: Results from a Longitudinal Observational Study
AbstractIntroductionTo assess clinical and ultrasound effectiveness  of steroid injection (local treatment, LT) into the digital flexor tendon sheath for the treatment of psoriatic dactylitis compared to systemic treatment (ST) alone.MethodsIn this observational, multicentre, prospective study, 88 cases of symptomatic hand dactylitis were evaluated clinically and sonographically by high-frequency ultrasound (US) probe in both greyscale (GS) and power Doppler (PD). The presence of flexor tenosynovitis (FT), soft tissue oedema (STO), peritendon extensor inflammation and synovitis was assessed (including DACtyl...
Source: Rheumatology and Therapy - October 15, 2021 Category: Rheumatology Source Type: research

Improvement in Patient-Reported Outcomes in Patients with Psoriatic Arthritis Treated with Upadacitinib Versus Placebo or Adalimumab: Results from SELECT-PsA 1
AbstractIntroductionThe aim of this work is to assess the effect of upadacitinib versus adalimumab and placebo on patient-reported outcomes (PROs) in psoriatic arthritis (PsA) patients with inadequate responses to  ≥ 1 non-biologic disease-modifying anti-rheumatic drugs (non-bDMARD-IR) in SELECT PsA-1.MethodsIn this placebo- and active comparator, phase 3 randomized, controlled trial, patients received daily upadacitinib 15 or 30  mg, placebo, or adalimumab 40 mg every other week through 56 weeks. At week 24, placebo-assigned patients were rerandomized to upadacitinib 15 or 30 mg. PROs ...
Source: Rheumatology and Therapy - October 12, 2021 Category: Rheumatology Source Type: research

Esophageal Dysfunction in Systemic Sclerosis: An Update
AbstractEsophageal motility disorders are prevalent in 90% of patients with systemic sclerosis [scleroderma (SSc)], with an increased mortality rate in patients with severe esophageal involvement. Esophageal smooth muscle damage caused by ischemia, nerve damage, and inflammatory factors may be responsible for discomfort and various complications in these patients. The clinical manifestations are diverse. Most hospitals still use traditional esophageal manometry and 24-h pH monitoring to diagnose esophageal function in patients with SSc. The aim of this review article is to provide an overview of SSc ‐related esophageal m...
Source: Rheumatology and Therapy - October 9, 2021 Category: Rheumatology Source Type: research

The Patient Experience of Fatigue in Systemic Lupus Erythematosus: A Conceptual Model
ConclusionsThe findings of this research indicate that comprehensive measurement of fatigue in SLE will require consideration and quantification of the three domains described in our conceptual model. Future research will explore whether this conceptual model can form the basis of a valid and reliable measurement of fatigue in SLE. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 8, 2021 Category: Rheumatology Source Type: research

Low-Dose Interleukin-2 as an Alternative Therapy for Refractory Lupus Nephritis
AbstractIntroductionLow-dose interleukin-2 (IL-2) selectively restores disturbances of regulatory T cells (Treg) and conventional T cells, resulting in the induction of remission in patients with systemic lupus erythematosus. However, to date no research has been carried out on the efficacy of low-dose IL-2 in the treatment of refractory lupus nephritis (LN). The aim of the study reported here was to investigate the renal response to low-dose IL-2 in patients with refractory LN.MethodsThe study population comprised ten patients with refractory LN who failed to achieve complete response or who had relapsed while being treat...
Source: Rheumatology and Therapy - October 7, 2021 Category: Rheumatology Source Type: research

A Pooled Analysis Reporting the Efficacy and Safety of Secukinumab in Male and Female Patients with Ankylosing Spondylitis
ConclusionComparable efficacy and safety outcomes were observed between male and female patients with active AS treated with secukinumab over 52  weeks. Further, sex was not an independent predictor of treatment response to secukinumab as assessed by ASAS40 responder rates and BASDAI change from baseline; association of ASDAS-CRP ID responder rates with sex warrants further exploration.Trial registrationClinicalTrials.gov; NCT01358175, NCT01649375, NCT02008916, NCT02159053, and NCT02896127. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 7, 2021 Category: Rheumatology Source Type: research

Single and Composite Endpoints of Within-Patient Improvement in Symptoms: Pooled Tanezumab Data in Patients with Osteoarthritis
ConclusionResponders on single pain endpoints were in many cases also responders on function or composite endpoints. Separation of tanezumab from placebo was similar and consistent across single and composite endpoints. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 4, 2021 Category: Rheumatology Source Type: research

Predictors, Risk Factors, and Incidence Rates of Psoriatic Arthritis Development in Psoriasis Patients: A Systematic Literature Review and Meta-Analysis
ConclusionsThis study provides a tentative profile of the PsO patient at risk of PsA and will help the design of PsA prevention trials. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - October 1, 2021 Category: Rheumatology Source Type: research

Exploring the Quality of Communication Between Patients with Psoriatic Arthritis and Physicians: Results of a Global Online Survey
ConclusionsPhysicians often underestimate the impacts of PsA, compared with patients, and some patients may be at risk of suboptimal communication with their attending  physician, which may worsen the HRQoL impacts of PsA. These findings highlight a need for ways to improve communication between patients with PsA and their healthcare providers. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 27, 2021 Category: Rheumatology Source Type: research

Correction to: A Closer Look at the Role of Anti-CCP Antibodies in the Pathogenesis of Rheumatoid Arthritis Associated Interstitial Lung Disease and Bronchiectasis
(Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 27, 2021 Category: Rheumatology Source Type: research

Racial Differences in Prevalence and Treatment for Psoriatic Arthritis and Ankylosing Spondylitis by Insurance Coverage in the USA
ConclusionsThe prevalence and treatment of PsA and AS differs by race/ethnicity, insurance coverage, and sex in the USA. Efforts for improving access to care are needed to improve outcomes among all patients. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 25, 2021 Category: Rheumatology Source Type: research

Pharmacokinetics and Safety of Intravenous and Subcutaneous Auto-injector Single-dose Belimumab in Healthy Chinese Volunteers: A phase 1, Randomized, Open-label Study
ConclusionsPK profiles of 200  mg SC and IV belimumab administrations were similar to previous studies, and safety profiles were acceptable, supporting the use of the SC dose in Chinese patients with SLE.Trial registrationNCT04136145. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 23, 2021 Category: Rheumatology Source Type: research

MRI Assessment of Extra-axial Findings at Pelvic Sites in a Group of Axial-SpA Patients
ConclusionsOur study demonstrated the presence of extra-axial abnormalities in more than one-third of patients with axial SpA, suggesting that MRI evaluation should be extended to the entire pelvis. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 20, 2021 Category: Rheumatology Source Type: research

The Risk Factors of Exacerbation in Interstitial Pneumonia With Autoimmune Features: A Single-Center Observational Cohort Study
ConclusionsIPAF patients with risk factors had a high exacerbation rate, regardless of the type of treatment. New interventions aimed at preventing exacerbations in these patients are required. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 18, 2021 Category: Rheumatology Source Type: research

Articular and Extra-Articular Benefits in ACR20 Non-responders at Week 104 Treated With Apremilast: Pooled Analysis of Three Randomized Controlled Trials
ConclusionDespite not fulfilling a formal ACR20 response at Week 104, ACR20NRs experienced sustained improvements in several PsA core domains, including SJC, TJC, enthesitis, dactylitis, and psoriasis, as well as the PhGA (visual analog scale) scores, with apremilast treatment.Trial RegistrationClinicalTrials.gov identifier: NCT01172938, NCT01212757, and NCT01212770. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 18, 2021 Category: Rheumatology Source Type: research

Antirheumatic Drug Intake Influence on Occurrence of COVID-19 Infection in Ambulatory Patients with Immune-Mediated Inflammatory Diseases: A Cohort Study
ConclusionsNo antirheumatic drug intake was associated with an increased or decreased risk of developing COVID-19 infection in our cohort of patients suffering from immune-mediated inflammatory diseases. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 16, 2021 Category: Rheumatology Source Type: research

Identification of a Rule to Predict Response to Sarilumab in Patients with Rheumatoid Arthritis Using Machine Learning and Clinical Trial Data
ConclusionsWell-established and clinically feasible blood biomarkers can guide individual treatment choice. Real-world validation of the rule identified in this post hoc analysis is merited.Clinical Trial RegistrationNCT01061736, NCT02332590, NCT01709578, NCT01768572. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 14, 2021 Category: Rheumatology Source Type: research

Differentiating Psoriatic Arthritis from Osteoarthritis and Rheumatoid Arthritis: A Narrative Review and Guide for Advanced Practice Providers
AbstractPsoriatic arthritis (PsA) is a chronic inflammatory disease that affects multiple organ systems and is characterized by skin and joint manifestations. PsA is frequently undiagnosed and/or misdiagnosed, especially because of the similarities in clinical presentation shared with other arthritic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). An accurate and timely diagnosis of PsA is crucial to prevent delays in optimal treatment, which can lead to irreversible joint damage and increased functional disability. Patients are usually seen by a number of different healthcare providers on their path...
Source: Rheumatology and Therapy - September 14, 2021 Category: Rheumatology Source Type: research

Occurrence of Possible Rheumatologic Immune-Related Adverse Events (rh-irAEs) Associated with Immune Checkpoint Inhibitor (ICI) Therapy
ConclusionsOccurrence of rh-irAEs during ICI use is higher in patients with pre-existing rheumatic disease compared to those with no pre-existing rheumatic disease. However, the most common events were not definitive rheumatic diseases but rather symptoms, such as pain in joints. Occurrence of events associated with a rheumatologist provider was substantially lower, suggesting that either patients are not referred to a rheumatologist or referral does not result in confirmation of the diagnosis by the rheumatologist. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 7, 2021 Category: Rheumatology Source Type: research

Clinical Management of Women with Newly Diagnosed Osteoporosis: Data from Everyday Practice in Bulgaria
ConclusionsThe duration of osteoporosis treatment in real-world clinical practice is far from optimal:
Source: Rheumatology and Therapy - September 6, 2021 Category: Rheumatology Source Type: research

Post Hoc Biomarker Analyses from a Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Repository Corticotropin Injection (Acthar ® Gel) for Persistently Active Systemic Lupus Erythematosus
AbstractIntroductionWe conducted post hoc analyses of biomarker results from a multicenter, randomized, double-blind, placebo-controlled study of repository corticotropin injection (RCI; Acthar ® Gel) in patients with persistently active systemic lupus erythematosus (SLE) despite treatment with moderate-dose glucocorticoids.MethodsAdults with active SLE and moderate to severe rash and/or arthritis were enrolled in the primary study. Patients had active SLE despite treatment with stable glucocorticoids, antimalarials, and nonsteroidal anti-inflammatory drugs and/or immunosuppressants. Patients were randomly assigned to ...
Source: Rheumatology and Therapy - September 3, 2021 Category: Rheumatology Source Type: research

Biologic and Targeted Synthetic DMARD Utilization in the United States: Adelphi Real World Disease Specific Programme for Rheumatoid Arthritis
ConclusionsTNFis remain the most prescribed b/tsDMARD for first-line and second-line treatments. Strong overall efficacy was the primary reason for selecting therapy and loss of efficacy was the primary reason for switching therapy. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 2, 2021 Category: Rheumatology Source Type: research

Correction to: Risk Factors for Progression from Subclinical to Clinical Phase of Psoriatic Arthritis: A Case –Control Study
(Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 2, 2021 Category: Rheumatology Source Type: research

Incidence of Infusion Reactions and Clinical Effectiveness of Intravenous Golimumab Versus Infliximab in Patients with Rheumatoid Arthritis: The Real-World AWARE Study
AbstractObjectiveEvaluate tolerability and effectiveness of golimumab-IV versus infliximab in patients with rheumatoid arthritis (RA) in a real-world setting.MethodsAWARE, a prospective, real-world, pragmatic, observational, multicenter, phase 4 study, enrolled RA patients when initiating golimumab-IV or infliximab. Treatment decisions were made by the treating rheumatologist. The approved doses for RA are 2  mg/kg at weeks 0, 4, then Q8W for golimumab-IV and 3 mg/kg at weeks 0, 2, 6, then Q8W (dose escalation permitted) for infliximab. A prespecified formal interim analysis was conducted. The primary endpoint wa...
Source: Rheumatology and Therapy - August 20, 2021 Category: Rheumatology Source Type: research

Patient-Reported Outcome Measures in Takayasu Arteritis: A Systematic Review and Meta-Analysis
ConclusionLiterature on PROMs in TAK, albeit sparse, appears to indicate worse scores in patients with TAK compared to healthy individuals. These results, however, require cautious interpretation. Development of a TAK-specific PROM is an important focus of the research agenda. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - August 16, 2021 Category: Rheumatology Source Type: research

Awareness and Expectations Surrounding Family Planning and Pregnancy Among Danish Patients with Chronic Inflammatory Disease of the Skin or Joints: Results from an Online Survey
ConclusionsDespite awareness of available sources of FPP information, patients expressed experiencing a feeling of limited access to information and having concerns that affect key decisions regarding FPP. The results of this survey highlight a need for improved and more standardised FPP information for patients with CIDs in Denmark. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - August 14, 2021 Category: Rheumatology Source Type: research

Self-Reported Weather Sensitivity is Associated with Clinical Symptoms and Structural Abnormalities in Patients with Knee Osteoarthritis: A Cross-Sectional Study
ConclusionsIn KOA patients, weather sensitivity was associated with clinical symptoms and structural abnormalities. Future longitudinal study is warranted for the causal relationship.Infographic (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - August 13, 2021 Category: Rheumatology Source Type: research

Novel Interventional Techniques for Chronic Pain with Minimally Invasive Arthrodesis of the Sacroiliac Joint: (INSITE, iFuse, Tricor, Rialto, and others)
AbstractAcute and chronic pain are public health issues that clinicians have been battling for years. Opioid medications have been a treatment option for both chronic and acute pain; however, they can cause unwanted complications and are a major contributor to our present opioid epidemic. The sacroiliac (SI) joint is a common cause of both acute and chronic low back pain. It affects about 15 –25% of patients with axial low back pain, and up to 40% of patients with ongoing pain following lumbar fusion. Recent advances in the treatment of SI joint pain have led to the development of a wide variety of SI joint fusion de...
Source: Rheumatology and Therapy - July 30, 2021 Category: Rheumatology Source Type: research

Real-World Safety and Effectiveness of Golimumab in Rheumatic Diseases: Post-Marketing Surveillance in Korea
ConclusionIn the real-world setting, golimumab was safe and effective in Korean patients with RA, PsA, and AS. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 29, 2021 Category: Rheumatology Source Type: research

Prevalence of Renal Impairment in a US Commercially Insured Rheumatoid Arthritis Population: A Retrospective Analysis
ConclusionsApproximately 7 –10% of commercially insured adult patients in the US with RA had moderate or severe renal impairment. Assessment of renal function is an important consideration for safe treatment. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 28, 2021 Category: Rheumatology Source Type: research

Pain Medication and Corticosteroid Use in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis in the United States: A Retrospective Observational Study
AbstractObjectiveWe compared pain medication use in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) versus matched control over 2  years; a subgroup analysis assessed changes in pain medication use in patients who initiated a biologic during 12 months before and after.MethodsThis was a retrospective observational cohort study using an administrative claims database. Newly diagnosed adult patients with AS, PsA, or RA identified between 1/1/2014 and 7/31/2017 were included. Demographics, baseline characteristics, and pain medication use were described using descriptive...
Source: Rheumatology and Therapy - July 26, 2021 Category: Rheumatology Source Type: research

The “Climb” Towards Minimal Disease Activity in Psoriatic Arthritis
ConclusionsThe present study detailed the domains more achieved also in those patients not in MDA showing that “physician-driven” domains are more frequently achieved in our patients. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 24, 2021 Category: Rheumatology Source Type: research

TNF- α Blockers Showed Prophylactic Effects in Preventing COVID-19 in Patients with Rheumatoid Arthritis and Seronegative Spondyloarthropathies: A Case–Control Study
AbstractIntroductionThe interaction between angiotensin-converting enzyme 2 (ACE2) and SARS-CoV-2 is a crucial factor in the viral infections leading to the release of inflammatory proteins, such as TNF- α. Thus, it is hypothesized that TNF-α blockers can prevent either COVID-19 incidence or its serious symptoms. TNF-α blockers are prescribed to treat various autoimmune disorders, including rheumatoid arthritis (RA) and seronegative spondyloarthropathies (SpA). Therefore, the objective of this wo rk was to examine this hypothesis that TNF-α blockers can prevent COVID-19 incidence in patients with RA...
Source: Rheumatology and Therapy - July 23, 2021 Category: Rheumatology Source Type: research

Therapeutic Effects of Ba-Duan-Jin versus Pregabalin for Fibromyalgia Treatment: Protocol for a Randomized Controlled Trial
AbstractIntroductionFibromyalgia is characterized by multi-focal pain and is associated with fatigue, unrefreshing sleep and psychological impairment. Pregabalin is one of the most frequently used agents in fibromyalgia treatment. However, it has failed to demonstrate benefit over placebo for reducing fatigue and psychological impairment, and may cause adverse effects (e.g. somnolence, dizziness). “Ba-Duan-Jin” (BDJ) is a common form of “Qigong” exercise for health promotion in China. Growing evidence suggests that BDJ may achieve satisfactory control of fibromyalgia-related symptoms in Chinese pati...
Source: Rheumatology and Therapy - July 22, 2021 Category: Rheumatology Source Type: research

Factors Associated with Health-Related Quality of Life in Psoriatic Arthritis Patients: A Longitudinal Analysis
ConclusionsMusculoskeletal manifestations and comorbidities exert a deleterious effect in HRQoL of PsA patients. Therefore, the optimal management of this condition needs to also address these manifestations in order to try to restore the QoL of these patients. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 21, 2021 Category: Rheumatology Source Type: research

Cost-Effectiveness of Therapeutic Drug Monitoring-Guided Adalimumab Therapy in Rheumatic Diseases: A Prospective, Pragmatic Trial
ConclusionAdalimumab dose tapering based on TDM for rheumatic patients led to an increased quality of life and QALY gain and entailed lower costs, being a more cost-effective alternative than clinically guided management. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 18, 2021 Category: Rheumatology Source Type: research

Evaluation of Real-World Healthcare Resource Utilization and Associated Costs in Children with Juvenile Idiopathic Arthritis: A Canadian Retrospective Cohort Study
ConclusionThe care pathway for children with JIA can be expensive, and complex —and varies by JIA subtype. Although the yearly total mean cost per patient was constant, the distribution of costs changes over time with the introduction of biologic therapies later in the care pathway. This study provides a better understanding of the JIA costs profile and can help inform futur e economic studies. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 18, 2021 Category: Rheumatology Source Type: research

Psychometric Analysis from EMBODY1 and 2 Clinical Trials to Help Select Suitable Fatigue PRO Scales for Future Systemic Lupus Erythematosus Studies
ConclusionsFACIT-F, SF-36 Vitality, and LupusQoL Fatigue were found to have important limitations in the EMBODY1 and EMBODY2 SLE clinical trials. Findings from pooled fatigue items support the need for further research to improve conceptual underpinnings of fatigue PROs and make them fit for purpose for drug development. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 9, 2021 Category: Rheumatology Source Type: research

Nurse-Led Care for Stable Patients with Rheumatoid Arthritis: Quality of Care in Routine Practice Compared to the Traditional Rheumatologist-Led Model
ConclusionsThis study provided real-world evidence that the evaluated NLC model providing protocolized follow-up care for stable patients with RA is effective to address patients ’ needs for ongoing disease monitoring, chronic disease management, education, and support. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 8, 2021 Category: Rheumatology Source Type: research

Osteonecrosis in Primary Antiphospholipid Syndrome is Associated with Previous Glucocorticoid Use and Thrombocytopenia
ConclusionAVN is rare in patients with pAPS and may be associated with thrombocytopenia and previous glucocorticoid use. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 6, 2021 Category: Rheumatology Source Type: research

Sj ögren’s Syndrome and Viral Infections
In this study, we summarize recent developments in our understanding of the relationship between SS and viral infections, including Epstein–Barr virus (EBV), hepatitis C virus (HCV), human T cell lymphotropic virus type 1 (HTLV-1), cytomegalovirus (CMV), and hu man immunodeficiency virus (HIV). (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 5, 2021 Category: Rheumatology Source Type: research

Features and Outcomes of Microcrystalline Arthritis Treated by Biologics: A Retrospective Study
ConclusionAnakinra was prescribed for cases of refractory crystal-associated arthritis or cases with contraindications for usual treatments. The efficacy of anakinra in treating CCPD was not obvious. Patients with CCPD had more side effects. The biotherapy was introduced with a long-term objective, while anti-IL-1 therapies are approved for acute crises only. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - July 4, 2021 Category: Rheumatology Source Type: research

Secukinumab Efficacy on Psoriatic Arthritis GRAPPA-OMERACT Core Domains in Patients with or Without Prior Tumor Necrosis Factor Inhibitor Use: Pooled Analysis of Four Phase  3 Studies
The objective of this study was to evaluate the effect of prior tumor necrosis factor inhibitor (TNFi) exposure on the efficacy of secukinumab across PsA core domains.MethodsData were pooled from 2049 participants with PsA in four phase  3 studies (FUTURE 2–5). Efficacy at week 16 was evaluated for each GRAPPA-OMERACT PsA core domain using nonresponder imputation for musculoskeletal disease activity and Psoriasis Area and Severity Index scores or as-observed data for other outcomes. For each measure, comparisons with placebo w ere made separately in the TNFi-naive and TNFi-inadequate responder/intolera...
Source: Rheumatology and Therapy - July 3, 2021 Category: Rheumatology Source Type: research

Malignancy Risk of Immunoglobin G4-Related Disease: Evidence from a Large Cohort Multicenter Retrospective Study
ConclusionsA significantly increased prevalence of total malignancies was observed in our multicenter cohort. Eosinophil percentage and autoimmune pancreatitis are risk factors, whereas AGR is negatively associated with malignancy in IgG4-RD. A prediction model for malignancy risk of IgG4-RD was first developed and validated in our study. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - June 28, 2021 Category: Rheumatology Source Type: research

Baricitinib and the Risk of Incident Interstitial Lung Disease: A Descriptive Clinical Case Report from Clinical Trials
ConclusionsThe findings of this analysis in patients with RA treated with baricitinib are consistent with a low risk to develop non-infectious ILD during baricitinib treatment, similar to that observed with other Janus kinase inhibitors. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - June 28, 2021 Category: Rheumatology Source Type: research

Patient Experiences, Satisfaction, and Expectations with Current Systemic Lupus Erythematosus Treatment: Results of the SLE-UPDATE Survey
ConclusionSLE patients reported high rates of satisfaction with current therapies despite identifying substantial treatment burdens, residual pain, and fatigue. Reduced fatigue, pain, and flares were the most important treatment goals for these patients. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - June 24, 2021 Category: Rheumatology Source Type: research

The Clinical Characteristics of Leukopenia in Patients with Systemic Lupus Erythematosus of Han Ethnicity in China: A Cross-Sectional Study
ConclusionsIn Han Chinese patients with SLE, leukopenia, neutropenia, and lymphopenia are common clinical manifestations, and the degree of reduction in blood cell count was also remarkable. Lymphopenia is associated with disease severity in patients with SLE. The correlation between Coombs ’ test results and lymphopenia deserves further study. (Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - June 20, 2021 Category: Rheumatology Source Type: research