Factors Influencing Iatrogenic Skin Injury in Neonates and Nursing Strategies
CONCLUSION: Length of stay, orotracheal intubation use, and gastric tube use are independent risk factors for iatrogenic skin injury in neonates. Hospital stays and unnecessary use of orotracheal intubation and gastric tube should be reduced in future clinical management. Attention should be paid to strengthening skin observation and care, keeping skin dry and clean, and preventing iatrogenic skin injury.PMID:38687850 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Huifang Deng Chunhua Li Nuo Yu Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Clinical Genitourinary Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
Concomitant Moderate to Severe Cutaneous Lesions Have Marked Impact on Quality of Life in Patients with Active Systemic Lupus Erythematosus: A Cross-Sectional Insight from Two Phase 3 Randomised Clinical Trials in Adults
Br J Dermatol. 2024 Apr 30:ljae183. doi: 10.1093/bjd/ljae183. Online ahead of print.NO ABSTRACTPMID:38687872 | DOI:10.1093/bjd/ljae183 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 30, 2024 Category: Dermatology Authors: Mischa J Mallbris Bochao Jia Youna Zhao J Michelle Kahlenberg Johann E Gudjonsson Source Type: research
In vitro study of cold atmospheric plasma-activated liquids inhibits malignant melanoma by affecting macrophage polarization through the ROS/JAK2/STAT1 pathway
This study illustrates that PAL therapy is an effective tumor immunotherapy and expands the scope of tumor immunotherapy. Furthermore, these findings establish a theoretical foundation for potential clinical applications of PAL.PMID:38688171 | DOI:10.1016/j.biopha.2024.116657 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Cheng Chen Shiyun Zhou Xingyu Yang Miaomiao Ren Yongshuang Qi Yiwen Mao Chunjun Yang Source Type: research
Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
In conclusion, these findings declare that VV polyphenolic fractions, particularly VVF1, could be promising safe anti-HCC agents.PMID:38688169 | DOI:10.1016/j.biopha.2024.116638 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2024 Category: Drugs & Pharmacology Authors: Nadia Z Shaban Walaa A Hegazy Marwa M Abu-Serie Iman M Talaat Olfat M Awad Noha H Habashy Source Type: research
Age group-specific changes in keratinocyte cancer treatment rates in Australia, 2012- 2021: a retrospective cohort study based on MBS claims data
CONCLUSIONS: Rates of MBS-subsidised treatment for keratinocyte cancers increased during 2012-2019, but BCC/SCC treatment rates declined among younger Australians, who have probably been exposed to less sunlight than earlier generations because of public health interventions and population-wide lifestyle changes related to technology use.PMID:38685827 | DOI:10.5694/mja2.52293 (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - April 30, 2024 Category: General Medicine Authors: Catherine M Olsen Nirmala Pandeya Rachel E Neale David C Whiteman Source Type: research
Wound Healing Activity of Topical Herbal Gels Containing Barringtonia acutangula Fruit Extract: In silico and In vivo Studies
Chem Biodivers. 2024 Apr 30:e202400147. doi: 10.1002/cbdv.202400147. Online ahead of print.ABSTRACTThe current study describes the efficacy of B. acutangula fruit extract in wound healing via incorporation within topical gels. B. acutangula fruit extract was produced by solvent extraction method. The bioactive extract was incorporated within Carbopol 940-based topical gels, which were applied topically over the excision and incision wounds. The change in healing process was observed till 20 days. The percentages of closure of excision wound area were 92.89% and 93.43%, when treated with topical herbal gels containing B. ac...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Kumari Priyanka Rudra Narayan Sahoo Ashirbad Nanda Satish Kanhar Chandan Das Abhijit Sahu Pradeep Kumar Naik Amit Kumar Nayak Source Type: research
Tomotherapy in synchronous and metachronous bilateral breast cancer: Clinical experience
CONCLUSION: Our results show the efficacy of using helical Tomotherapy considering positive outcomes, being that three out of four patients are in remission with low acute toxicity and late complications. There are a small number of articles describing bilateral breast cancer treatment with helical Tomotherapy. On this occasion, our data could contribute to the studies of tolerant doses for organs at risk and improve the parameters of treatment plans for bilateral breast cancer. Since the small sample of patients with bilateral breast cancer limits the study, a larger cohort of patients is essential to obtain statistically...
Source: Journal of Applied Clinical Medical Physics - April 30, 2024 Category: Physics Authors: Yernar Orda Tanzhas Shayakhmetov Saniya Baiturova Daulet Berikbol Rauan Otynshiyev Aigul Brimova Bolat Saktashev Ainur Baisalbayeva Ainur Samigatova Source Type: research
TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
Exp Mol Med. 2024 May 1. doi: 10.1038/s12276-024-01225-y. Online ahead of print.ABSTRACTRecent evidence of gut microbiota dysbiosis in the context of psoriasis and the increased cooccurrence of inflammatory bowel disease and psoriasis suggest a close relationship between skin and gut immune responses. Using a mouse model of psoriasis induced by the Toll-like receptor (TLR) 7 ligand imiquimod, we found that psoriatic dermatitis was accompanied by inflammatory changes in the small intestine associated with eosinophil degranulation, which impaired intestinal barrier integrity. Inflammatory responses in the skin and small inte...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Hee Joo Kim Jinsun Jang Kunhee Na Eun-Hui Lee Hyeon-Jung Gu Yoon Hee Lim Seul-A Joo Seung Eun Baek Joo-Young Roh Han-Joo Maeng Yun Hak Kim Young-Jae Lee Byung-Chul Oh YunJae Jung Source Type: research
Cutaneous glands of the striped toad, Rhinella crucifer (Wied-Neuwied, 1821) (Amphibia: Bufonidae): Histological study and bioactivities of glandular secretions
This study investigated the morphology of Rhinella crucifer cutaneous glands, as well as the protein/peptide profiles and bioactivities of body gland secretions (BGS) and parotoid macrogland secretions (PS). The parotoid as well as dorsal and ventral skin fragments of male and female individuals were processed for histological analysis. The protein and peptide profiles of male and female gland secretions were evaluated. Male secretions were also assessed for proteolytic, trypsin inhibiting, hemagglutinating, hemolytic, antimicrobial, and anticoagulant activities. The R. crucifer skin structure presented protuberances that ...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - April 30, 2024 Category: Biochemistry Authors: Gessica Gomes Barbosa Tul íbia Laurindo Silva Ana Patr ícia Silva de Oliveira Th âmarah de Albuquerque Lima Pollyanna Michelle da Silva Carlos Jos é Correia de Santana Jeymesson Raphael Cardoso Vieira Dyeime Ribeiro de Sousa Francisco Assis Leite Souz Source Type: research
Promoting clinical research in community-based practice: Threats and opportunities
Ann Dermatol Venereol. 2024 Apr 29;151(2):103272. doi: 10.1016/j.annder.2024.103272. Online ahead of print.NO ABSTRACTPMID:38688174 | DOI:10.1016/j.annder.2024.103272 (Source: Annales de Dermatologie et de Venereologie)
Source: Annales de Dermatologie et de Venereologie - April 30, 2024 Category: Dermatology Authors: F Poizeau A Maruani D Staumont-Sall é N Jouan S Ly M Schollhammer M Reverte C Dibao-Dina T-A Duong B Matard D Penso-Assathiany A Dupuy M Carriot J-F Se ï F Corgibet B Guillot S Barbarot S Leducq A Bertolotti J Tannous G Chaby D Jullien E P épin G Qu é Source Type: research
Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing
Mini Rev Med Chem. 2024 Apr 29. doi: 10.2174/0113895575299255240422055203. Online ahead of print.ABSTRACTSkin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflamm...
Source: Mini Reviews in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Seyedeh Mohaddeseh Mousavi Leila Etemad Davood Yari Maryam Hashemi Zahra Salmasi Source Type: research
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing
Int J Biol Macromol. 2024 Apr 28:131948. doi: 10.1016/j.ijbiomac.2024.131948. Online ahead of print.ABSTRACTThe process of wound healing includes the inflammatory stage, which plays an important role. Macrophages can promote inflammatory response and also promote angiogenesis, wound contraction and tissue remodeling required for wound healing. It is crucial to promote macrophages to polarize from M1 pro-inflammatory phenotype to M2 anti-inflammatory phenotype at a critical time for the quality of wound healing. Because mesenchymal stem cell-derived exosomes have broad therapeutic prospects in the field of tissue repair and...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Tingyu Wang Yuanye Xue Wenwen Zhang Zetai Zheng Xinsheng Peng Yanfang Zhou Source Type: research
Preparation of nano-silver containing black phosphorus based on quaternized chitosan hydrogel and evaluating its effect on skin wound healing
Int J Biol Macromol. 2024 Apr 27:131950. doi: 10.1016/j.ijbiomac.2024.131950. Online ahead of print.ABSTRACTHydrogels with favorable biocompatibility and antibacterial properties are essential in postoperative wound hemorrhage care, facilitating rapid wound healing. The present investigation employed electrostatic adsorption of black phosphorus nanosheets (BPNPs) and nano‑silver (AgNPs) to cross-link the protonated amino group NH3+ of quaternized chitosan (QCS) with the hydroxyl group of hyaluronic acid (HA). The electrostatic interaction between the two groups resulted in the formation of a three-dimensional gel network...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Tianjiao Li Jiaqi Zhao Yajuan Yue Bo Han Wenjuan Wang Han Zhang Zhiyong Liu Zhenyang Chen Xing Tian Source Type: research
The molecular arrangement of ceramides in the unit cell of the long periodicity phase of stratum corneum models shows a high adaptability to different ceramide head group structures
In this study, the impact of the CER head group structure on the lipid arrangement and barrier functionality was investigated using lipid models forming the LPP. The results demonstrate that the positions of CER N-(tetracosanoyl)-sphingosine (CER NS) and CER N-(tetracosanoyl)-phytosphingosine (CER NP), two essentials CER subclasses, are not influenced by the addition of another CER subclass (N-(tetracosanoyl)-dihydrosphingosine (CER NdS), N-(2R-hydroxy-tetracosanoyl)-sphingosine (CER AS) or D-(2R-hydroxy-tetracosanoyl)-phytosphingosine (CER AP)). However, differences are observed in the lipid organization and the hydrogen ...
Source: Biochimica et Biophysica Acta - April 30, 2024 Category: Biochemistry Authors: Andreea N ădăban Gerrit S Gooris Charlotte M Beddoes Robert M Dalgliesh Marc Malfois Bruno Dem é Joke A Bouwstra Source Type: research
