Translation and implementation of the Australian-led PCOS guideline: clinical summary and translation resources from the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Authors: Teede HJ, Misso ML, Boyle JA, Garad RM, McAllister V, Downes L, Gibson M, Hart RJ, Rombauts L, Moran L, Dokras A, Laven J, Piltonen T, Rodgers RJ, Thondan M, Costello MF, Norman RJ, International PCOS Network Abstract INTRODUCTION: We have developed the first international evidence-based guideline for the diagnosis and management of polycystic ovary syndrome (PCOS), with an integrated translation program incorporating resources for health professionals and consumers. The development process involved an extensive Australian-led international and multidisciplinary collaboration of health professionals and co...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Diagnosis of severe asthma.
Authors: Tay TR, Lee JW, Hew M Abstract Patients with asthma that is uncontrolled despite high intensity medication can present in both primary and specialist care. An increasing number of novel (and expensive) treatments are available for patients who fail conventional asthma therapy, but these may not be appropriate for all such patients. It is essential that a rigorous evaluation process be undertaken for these patients to identify those with biologically severe asthma who will require novel therapies, and those who may improve with control of contributory factors. In this article, we describe three key steps in...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Managing comorbid conditions in severe asthma.
Authors: Bardin PG, Rangaswamy J, Yo SW Abstract Asthma care has increasingly focused on personalised management for severe asthma, and recognition of the role and importance of comorbid conditions has increased. Severe asthma can be crippling; associated comorbid conditions often play a key role in the significant disease morbidity and frequently contribute to a severe and difficult-to-treat asthma phenotype. Comorbid conditions can be broadly grouped as being either airway-related or airway-unrelated. Airway-related comorbid conditions with the greatest impact are allergic rhinitis, chronic rhinosinusitis, vocal ...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Appropriate use of oral corticosteroids for severe asthma.
Authors: Ramsahai JM, Wark PA Abstract Severe asthma represents a significant burden of disease, particularly in high income nations; oral corticosteroids (OCS) remain an important part of the management toolkit for these patients. Corticosteroids are effective at targeting numerous elements of the type 2/eosinophilic inflammatory pathway and lead to both rapid reduction in eosinophilic inflammation and longer term reduction in airway hyper-responsiveness. Resistance or insensitivity to corticosteroids is a feature of severe asthma, with persistent type 2 inflammation often occurring despite regular use of OCS. OCS...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Optimising treatment for severe asthma.
Authors: Upham JW, Chung LP Abstract The treatment landscape in severe asthma is changing rapidly, with multiple new therapies emerging that promise to transform patient outcomes. In a patient who is not responding to conventional therapy with inhaled corticosteroids and long-acting β2-agonists, it is important to first consider if the diagnosis of asthma is correct and, second, to reflect on whether readily modifiable factors are contributing to poor asthma control. In selected patients it may be appropriate to consider a modified n-of-1 trial of add-on therapies such as long-acting anti-muscarinic agents, le...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Health-related quality of life burden in severe asthma.
Authors: McDonald VM, Hiles SA, Jones KA, Clark VL, Yorke J Abstract It is largely unrecognised that the impacts of asthma are different in patients with severe disease compared with patients with mild to moderate disease. Severe asthma is associated with a significant health-related quality of life (HRQoL) burden due to excessive symptoms, frequent and life-threatening attacks, increased comorbidity burden, and high pharmacological treatment requirements. Interventions aimed at improving HRQoL need to be specifically tested in populations with severe asthma, including multicomponent interventions targeting the man...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Models of care for severe asthma: the role of primary care.
Authors: Chung LP, Johnson P, Summers Q Abstract Severe asthma encompasses treatment-refractory asthma and difficult-to-treat asthma. There are a number of barriers in primary, secondary and tertiary settings which compromise optimal care for severe asthma in Australia. Guidelines recommend a multidimensional assessment of severe asthma, which includes confirming the diagnosis, severity and phenotype and identifying and treating comorbidities and risk factors. This approach has been found to improve severe asthma symptoms and quality of life and reduce exacerbations. Primary care providers can contribute significan...
Source: Medical Journal of Australia - November 22, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

The value of participating in clinical trials: the whole is greater than the sum of its parts.
Authors: Zalcberg JR, Friedlander M PMID: 30428815 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

What have we learnt about using digital technologies in health professional education?
Authors: Wozniak H, Ellaway RH, de Jong PG PMID: 30428816 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Acute kidney injury in an older patient.
Authors: Vlismas L, Coleman H, Lea-Henry TN, Chacko B PMID: 30428817 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Reducing cardiovascular risk in people with diabetes and kidney disease.
Authors: Neuen BL, Perkovic V PMID: 30428818 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Planetary health: the Australian chapter.
Authors: Lo SN, Ferguson K, Kayak E, Faulkner K PMID: 30428819 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Health protection and Australian prisons, 2018.
Authors: Levy MH, Treloar CJ PMID: 30428820 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Retention of medical records of patients with high-risk medical devices.
Authors: Cooter RD, Hopper I, McNeil JJ PMID: 30428821 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

The three A's of colonoscopy referral.
Authors: Bampton P, Sammour T, Brown GJ, Hewett DG, Worthley DL PMID: 30428822 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Hypertrophic lichen planus mistaken for squamous cell carcinoma.
Authors: Shao EX, Carew B, Muir J PMID: 30428823 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

RACGP's cream of the crop recognised.
Authors: PMID: 30428824 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Calendar of conferences in Australia and New Zealand.
Authors: PMID: 30428825 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 16, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Medicinal cannabis for chemotherapy-induced nausea and vomiting: prescribing with limited evidence.
Authors: Mersiades AJ, Stockler MR, Olver IN, Grimison P PMID: 30404590 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 9, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Gluten in "gluten-free" manufactured foods in Australia: a cross-sectional study.
Gluten in "gluten-free" manufactured foods in Australia: a cross-sectional study. Med J Aust. 2018 Nov 12; Authors: Halmos EP, Clarke D, Pizzey C, Tye-Din JA PMID: 30404591 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 9, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Deprescribing proton pump inhibitors: why, when and how.
Authors: Bytzer P PMID: 30404592 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 9, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

The first published randomised controlled trial of laser treatment for vaginal atrophy raises serious questions.
Authors: Buttini MJ, Maher C PMID: 30376654 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

A perfect storm: towards reducing the risk of suicide in the medical profession.
Authors: McCormack AI PMID: 30376655 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Endemic unprofessional behaviour in health care: the mandate for a change in approach.
Authors: Westbrook J, Sunderland N, Atkinson V, Jones C, Braithwaite J PMID: 30376656 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Clinical supervision in rural Australia: challenges and opportunities.
Authors: Martin P, Sen Gupta T, Douyere JM PMID: 30376657 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Menagerie: < em > Bartonella henselae < /em > chorioretinitis in the setting of diverse animal exposure.
Menagerie: Bartonella henselae chorioretinitis in the setting of diverse animal exposure. Med J Aust. 2018 Nov 05;209(9):284-286 Authors: Nonaka F, Carden SM, Butters C, Chen C PMID: 30376658 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Programmatic assessment: the process, rationale and evidence for modern evaluation approaches in medical education.
Authors: van der Vleuten C, Lindemann I, Schmidt L PMID: 30376659 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Pre-conception care: an important yet underutilised preventive care strategy.
Authors: Bateson DJ, Black KI PMID: 30376660 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

How to improve the wellbeing of junior doctors: building the evidence.
Authors: Roberts-Thomson RL, Kirchner SD PMID: 30376661 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

The ecology of survival for new medical graduates.
Authors: Willcock SM PMID: 30376662 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Updated clinical practice guidelines on pregnancy care.
Authors: Homer CS, Oats J, Middleton P, Ramson J, Diplock S Abstract INTRODUCTION: The clinical practice guidelines on pregnancy care have been developed to provide reliable and standardised guidance for health professionals providing antenatal care in Australia. They were originally released as the Clinical Practice Guidelines: Antenatal Care in two separate editions (modules 1 and 2) in 2012 and 2014. These modules have now been combined and updated to form a single set of consolidated guidelines that were publicly released in February 2018 as the Clinical Practice Guidelines: Pregnancy Care. Eleven topics have b...
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Preventing ovarian failure associated with chemotherapy.
Authors: Cui W, Stern C, Hickey M, Goldblatt F, Anazodo A, Stevenson WS, Phillips KA Abstract Alkylating chemotherapy is often used to treat pre-menopausal women for various malignancies and autoimmune diseases. Chemotherapy-associated ovarian failure is a potential consequence of this treatment which can cause infertility, and increases the risk of other long term adverse health sequelae. Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in preventing chemotherapy-associated ovarian...
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Excellence in two worlds of medicine and journalism.
Authors: Swannell C PMID: 30376665 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Calendar of conferences in Australia and New Zealand.
Authors: PMID: 30376666 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - November 1, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Revised Australian national guidelines for colorectal cancer screening: family history.
We describe the rationale, evidence and recommendations for colorectal cancer screening by family history for people without a genetic syndrome, as reported in the 2017 revised Australian guidelines. Main recommendations: Based on 10-year risks of colorectal cancer, people at near average risk due to no or weak family history (category 1) are recommended screening by immunochemical faecal occult blood test (iFOBT) every 2 years from age 50 to 74 years. Individuals with moderate risk due to their family history (category 2) are recommended biennial iFOBT from age 40 to 49 years, then colonoscopy every 5 years from age 50 to...
Source: Medical Journal of Australia - October 26, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Ensuring safety in public playgrounds is everybody's business.
Authors: Barker RA, Eager D, Sharwood LN PMID: 30359559 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 26, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

The value of peer mentoring for the psychosocial wellbeing of junior doctors: a randomised controlled study.
CONCLUSION: An optional peer mentoring program enhances junior doctor support structures, builds a sense of community, and helps participating interns navigate their new professional environment. Our trial provides a feasibility model that could be adapted to local conditions, regionally or nationally. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry, ACTRN12618000455268; 29 March 2018 (retrospective). PMID: 30332934 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 20, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

The right kind of viral: boosted Facebook advertisements for health protection messages.
Authors: Glasgow KM, Bateman-Steel CR, Pope B, Ferson MJ PMID: 30332935 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 20, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Type 2 diabetes in patients with end-stage kidney disease: influence on cardiovascular disease-related mortality risk.
CONCLUSIONS: Mortality risk is higher for patients with incident ESKD commencing dialysis who also have type 2 diabetes than for patients without diabetes, particularly among patients under 50 years of age, and the risk was more pronounced in patients for whom ESKD was attributed to diabetic nephropathy. PMID: 30332936 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 20, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Community-acquired acute meningitis and encephalitis: a narrative review.
Authors: Beaman MH Abstract Meningitis and encephalitis are medical emergencies. Patients need prompt evaluation and immediate empiric therapy to reduce the likelihood of fatal outcomes and chronic neurological sequelae. Conjugate bacterial vaccines have significantly reduced the incidence of bacterial meningitis, especially in children. As the results of changes in patterns of bacterial drug sensitivity, ceftriaxone is now part of the recommended empiric treatment for bacterial meningitis and should be administered as early as possible. Neuroimaging delays the treatment of meningitis and is not needed in most case...
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Surveillance improves survival of patients with hepatocellular carcinoma: a prospective population-based study.
Authors: Hong TP, Gow PJ, Fink M, Dev A, Roberts SK, Nicoll A, Lubel JS, Kronborg I, Arachchi N, Ryan M, Kemp WW, Knight V, Sundararajan V, Desmond P, Thompson AJ, Bell SJ Abstract OBJECTIVES: To determine the factors associated with survival of patients with hepatocellular carcinoma (HCC) and the effect of HCC surveillance on survival. DESIGN, SETTING AND PARTICIPANTS: Prospective population-based cohort study of patients newly diagnosed with HCC in seven tertiary hospitals in Melbourne, 1 July 2012 - 30 June 2013. MAIN OUTCOME MEASURES: Overall survival (maximum follow-up, 24 months); factors associated w...
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Invictus Games, Sydney 2018.
Authors: Kidd P PMID: 30309302 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Trials and tribulations: improving outcomes for adolescents and young adults with rare and low survival cancers.
Authors: Walczak A, Patterson P, Thomas D PMID: 30309304 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Australia is responding to the complex challenge of overdiagnosis.
Authors: Moynihan R, Barratt AL, Buchbinder R, Carter SM, Dakin T, Donovan J, Elshaug AG, Glasziou PP, Maher CG, McCaffery KJ, Scott IA PMID: 30309305 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Subclavian vein thrombosis with internal jugular vein extension in an Australian rules football player.
Authors: Wong JW, Lai FW, Wilson I PMID: 30309306 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Fifty years of RhD immunoglobulin (anti-D) therapy in Australia: celebrating a public health success story.
Authors: Thyer J, Wong J, Thomson A, Bell B, Hyland C, Challis D PMID: 30309307 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Redefining the physician's role in the era of online health information.
Authors: Ieraci S PMID: 30309308 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Absolute cardiovascular disease risk and lipid-lowering therapy among Aboriginal and Torres Strait Islander Australians.
Authors: Schultz R PMID: 30309309 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Absolute cardiovascular disease risk and lipid-lowering therapy among Aboriginal and Torres Strait Islander Australians.
Authors: Lovett RW PMID: 30309310 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Bilateral primary meningococcal conjunctivitis in an Indigenous child.
Authors: Sterrey J, Abedi F, Henderson TR PMID: 30309311 [PubMed - in process] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 13, 2018 Category: General Medicine Tags: Med J Aust Source Type: research