Olaparib and niraparib as maintenance therapy in patients with newly diagnosed and platinum-sensitive recurrent ovarian cancer: A single-center study in China
CONCLUSIONS: Olaparib and niraparib were effective in patients with ovarian cancer without any new safety signals except for skin pigmentation. In patients with BRCAm, the 24-month PFS of the PARPi used in the PSR-M setting was even higher than that used in the FL-M setting.PMID:38679485 | DOI:10.1097/CM9.0000000000003125 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - April 28, 2024 Category: General Medicine Authors: Dengfeng Wang Xunwei Shi Jiao Pei Can Zhang Liping Peng Jie Zhang Jing Zheng Chunrong Peng Xiaoqiao Huang Xiaoshi Liu Hong Liu Guonan Zhang Source Type: research
Research progress of vitiligo repigmentation: from oxidative stress to autoimmunity
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):147-151. doi: 10.14715/cmb/2024.70.4.23.ABSTRACTVitiligo belongs to a frequent chronic autoimmune skin disease with the features of pigmented plaques on the diseased skin along with potential damage of melanocytes. There are many factors underlying the pathogenesis of vitiligo, among which oxidative stress is extensively regarded to be the critical factor leading to the loss of melanocytes. The changed redox state resulting from oxidative stress, containing ROS overproduction along with the reduced activity of the skin's antioxidant system, makes melanocytes less resistant ...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Tingting Yu Yan Wu Zhenzhong Lu Source Type: research
Vestibulodynia: Clinical characteristics, first-line treatments, and factors associated with escalation of treatment with EMG-guided injections of botulinum toxin in a retrospective french cohort study
CONCLUSION: Our study highlights the current lack of efficacy of first-line treatments in vestibulodynia. Considering the high prevalence of muscular dysfunction, botulinum toxin injections are of particular interest despite a lack of randomized controlled trials in this indication.PMID:38678773 | DOI:10.1016/j.annder.2024.103277 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: C Neuville B Parratte S Lombion F Aubin I Gallais S érézal F Pelletier Source Type: research
Pruriginous vesicular eruption associated with nivolumab immunotherapy: A case of dermatitis herpetiformis
Ann Dermatol Venereol. 2024 Apr 27;151(2):103269. doi: 10.1016/j.annder.2024.103269. Online ahead of print.NO ABSTRACTPMID:38678772 | DOI:10.1016/j.annder.2024.103269 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: M Housset A Fayad Kazour C Paugam Y Le Corre A Croue L Martin D Lechevalier C Berthin Source Type: research
Tele-expertise assessment of chronic wounds by advanced practice dermatology nurses
Ann Dermatol Venereol. 2024 Apr 27;151(2):103273. doi: 10.1016/j.annder.2024.103273. Online ahead of print.NO ABSTRACTPMID:38678771 | DOI:10.1016/j.annder.2024.103273 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: C Robin L Poiroux J Delaunay P Seuwou L Martin E D émoulins Source Type: research
Panitumumab-induced perforating collagenosis
Ann Dermatol Venereol. 2024 Apr 27;151(2):103271. doi: 10.1016/j.annder.2024.103271. Online ahead of print.NO ABSTRACTPMID:38678770 | DOI:10.1016/j.annder.2024.103271 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: N Kluger S Jokela L Tolkki Source Type: research
A rare case of granular parakeratosis of the glans resembling genital psoriasis
Ann Dermatol Venereol. 2024 Apr 27;151(2):103268. doi: 10.1016/j.annder.2024.103268. Online ahead of print.NO ABSTRACTPMID:38678769 | DOI:10.1016/j.annder.2024.103268 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: A Badaoui I Moulonguet Source Type: research
Routine dermatology training and tele-expertise for general practitioners
Ann Dermatol Venereol. 2024 Apr 27;151(2):103266. doi: 10.1016/j.annder.2024.103266. Online ahead of print.NO ABSTRACTPMID:38678767 | DOI:10.1016/j.annder.2024.103266 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: P Senet Source Type: research
PATEO syndrome
Ann Dermatol Venereol. 2024 Apr 27;151(2):103267. doi: 10.1016/j.annder.2024.103267. Online ahead of print.NO ABSTRACTPMID:38678768 | DOI:10.1016/j.annder.2024.103267 (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - April 28, 2024 Category: Dermatology Authors: N Lacroix D Anghel V Sibaud Source Type: research
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps
CONCLUSIONS AND IMPLICATIONS: Puerarin promoted flap survival from ischemic injury through upregulation of TFEB-mediated autophagy and inhibition of oxidative stress. Our findings offered valuable support for the clinical application of Puerarin in the treatment of ischemic diseases, including random-pattern flaps.PMID:38679118 | DOI:10.1016/j.ejphar.2024.176621 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Yingying Lai Ningning Yang Donghao Shi Xianhui Ma Yingying Huang Jingzhou Lu Xuzi Zhang Hui Zhou Weiyang Gao Cong Mao Long Wang Source Type: research
[Translated article] Retrospective study of home antibiotic infusion therapy using elastomeric infusion pumps
CONCLUSIONS: Outpatient antimicrobial therapy in elastomeric infusion pumps is an alternative in patients requiring prolonged intravenous treatment, and age is not a conditioning factor for inclusion in these programs. However, the presence of certain comorbidities can negatively affect the clinical course and mortality of patients.PMID:38679534 | DOI:10.1016/j.farma.2024.03.011 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - April 28, 2024 Category: Drugs & Pharmacology Authors: Sara Ferro Rodr íguez Yelco Chantres Legaspi Eva Mar ía Romay Lema Blanca Ayuso Garc ía Paloma Castellano Copa Pedro Pein ó Camba Andrea Barcia Losada Cristina Rodr íguez Díaz Source Type: research
Multi-omics analysis reveals inflammatory biomarkers for skin melanoma prognosis
Pigment Cell Melanoma Res. 2024 Apr 28. doi: 10.1111/pcmr.13172. Online ahead of print.NO ABSTRACTPMID:38679454 | DOI:10.1111/pcmr.13172 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - April 28, 2024 Category: Cytology Authors: Zhi-Qing Zhan Jia-Xin Li Xin-Lei Hu Source Type: research
Approach for contact medical device development via integrated testing, skeletal muscle modeling, and finite element analysis
J Mech Behav Biomed Mater. 2024 Apr 16;155:106541. doi: 10.1016/j.jmbbm.2024.106541. Online ahead of print.ABSTRACTDevelopment of novel medical devices for the treatment of musculoskeletal pain associated with neuro-muscular trigger points requires a model for relating the mechanical responses of in vivo biological tissues to applied palliative physical pressures and a method to design treatments for optimal effects. It is reasonable to hypothesize that the efficacy of therapeutic treatment is proportional to the maximum tensile strain at trigger point locations. This work presents modeling of the mechanical behavior of bi...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 28, 2024 Category: Materials Science Authors: Conor Shanley Q Jane Wang Bruce Livingston Source Type: research
KoCVAM-led Development of Phototoxicity Alternative Test Method using Reconstructed Human Epidermis model (KeraSkin ™)
Food Chem Toxicol. 2024 Apr 26:114698. doi: 10.1016/j.fct.2024.114698. Online ahead of print.ABSTRACTPhototoxicity is an acute toxic reaction induced by topical skin exposure to photoreactive chemicals followed by exposure to environmental light and thus chemicals that absorb UV are recommended to be evaluated for phototoxic potential. There are currently three internationally harmonized alternative test methods for phototoxicity. One of them is the in vitro Phototoxicity: RhE Phototoxicity test method (OECD TG498). Korean center for the Validation of Alternative Methods (KoCVAM) developed an in vitro phototoxicity test me...
Source: Food and Chemical Toxicology - April 28, 2024 Category: Food Science Authors: Nam-Hee Kang So-Hee Kim Joohwan Kim Source Type: research
Lebrikizumab monotherapy impacts on quality of life scores through improved itch and sleep interference in two Phase 3 trials
CONCLUSIONS: Improvement in itch and sleep interference due to itch is associated with improvement in the QoL of patients after treatment with lebrikizumab for moderate-to-severe AD.ClinicalTrials.gov registration NCT04146363 (ADvocate1) and NCT04178967 (ADvocate2).PMID:38679419 | DOI:10.1080/09546634.2024.2329240 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 28, 2024 Category: Dermatology Authors: Jennifer Soung Sonja St änder Jan Gutermuth Ignasi Pau-Charles Zach Dawson Fan Emily Yang Luna Sun Evangeline Pierce Hany Elmaraghy Linda Stein-Gold Source Type: research
