ABCB5 is activated by MITF and β-catenin and is associated with melanoma differentiation.
ABCB5 is activated by MITF andβ-catenin and is associated with melanoma differentiation. Pigment Cell Melanoma Res. 2019 Oct 08;: Authors: Louphrasitthiphol P, Chauhan J, Goding CR Abstract Defining markers of different phenotypic states in melanoma is important for understanding disease progression, determining the response to therapy, and defining the molecular mechanisms underpinning phenotype-switching driven by the changing intratumor microenvironment. The ABCB5 transporter is implicated in drug-resistance, and has been identified as a marker of melanoma-initiating cells. Indeed ongoing stud...
Source: Pigment Cell and Melanoma Research - October 8, 2019 Category: Cytology Authors: Louphrasitthiphol P, Chauhan J, Goding CR Tags: Pigment Cell Melanoma Res Source Type: research

Combined ipilimumab and nivolumab first-line and after BRAF targeted therapy in advanced melanoma.
Abstract Combination ipilimumab and nivolumab is a highly active systemic therapy for metastatic melanoma but can cause significant toxicity. We explore the safety and efficacy of this treatment in routine clinical practice, particularly in the setting of BRAF targeted therapy. Consecutive patients with unresectable stage IIIC/IV melanoma commenced on ipilimumab and nivolumab across 10 tertiary melanoma institutions in Australia were identified retrospectively. Data collected included demographics, response and survival outcomes. 152 patients were included for analysis, 39% were treatment-naïve and 22% failed...
Source: Pigment Cell and Melanoma Research - October 6, 2019 Category: Cytology Authors: Mason R, Dearden HC, Nguyen B, Oon JS, Smith JL, Randhawa M, Mant A, Warburton L, Lo S, Meniawy T, Guminski A, Parente P, Ali S, Haydon A, Long GV, Carlino MS, Millward M, Atkinson VG, Menzies AM Tags: Pigment Cell Melanoma Res Source Type: research

Evolutionary processes of melanomas from giant congenital melanocytic nevi.
Abstract Melanoma can develop in a congenital melanocytic nevus (CMN). In fact, a large CMN is associated with a high risk of developing melanoma. Although melanomas arising from CMNs are thought to have a pathogenesis distinct from conventional melanomas, no studies have been conducted on the evolution or tumor heterogeneity of CMN melanomas. We applied multi-region whole-exome sequencing to investigate the clonal nature of driver events and evolutionary processes in CMNs and melanomas arising from CMNs. In two patients, we observed an independent subclonal evolution in cancerized fields of CMNs and chromosome 8q...
Source: Pigment Cell and Melanoma Research - October 4, 2019 Category: Cytology Authors: Lim Y, Shin HT, Choi Y, Lee DY Tags: Pigment Cell Melanoma Res Source Type: research

Delineating the Role of MITF Isoforms in Pigmentation and Tissue Homeostasis.
Abstract MITF, a gene that is mutated in familial melanoma and Waardenburg syndrome, encodes multiple isoforms expressed from alternative promoters that share common coding exons but have unique amino termini. It is not completely understood how these isoforms influence pigmentation in different tissues and how expression of these independent isoforms of MITF are regulated. Here, we show that melanocytes express two isoforms of MITF, MITF-A and MITF-M. Expression of MITF-A is partially regulated by a newly identified retinoid enhancer element located upstream of the MITF-A promoter. Mitf-A knockout mice have only ...
Source: Pigment Cell and Melanoma Research - September 28, 2019 Category: Cytology Authors: Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J, Ganesan AK Tags: Pigment Cell Melanoma Res Source Type: research

Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling.
Abstract The epidermis is the first line of defense against ultraviolet (UV) light from the sun. Keratinocytes and melanocytes respond to UV exposure by eliciting a tanning response dependent in part on paracrine signaling, but how keratinocyte:melanocyte communication is regulated during this response remains understudied. Here we uncover a surprising new function for the keratinocyte-specific cell-cell adhesion molecule desmoglein 1 (Dsg1) in regulating keratinocyte:melanocyte paracrine signaling to promote the tanning response in the absence of UV exposure. Melanocytes within Dsg1-silenced human skin equivalent...
Source: Pigment Cell and Melanoma Research - September 28, 2019 Category: Cytology Authors: Arnette CR, Roth-Carter QR, Koetsier JL, Broussard JA, Burks HE, Cheng K, Amadi C, Gerami P, Johnson JL, Green KJ Tags: Pigment Cell Melanoma Res Source Type: research

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance towards MEK inhibition in NRAS mutant melanoma.
Abstract NRAS mutations are the most common alterations among RAS isoforms in cutaneous melanoma, with patients harboring these aggressive tumors having a poor prognosis and low survival rate. The main line of treatment for these patients is MAPK pathway-targeted therapies, such as MEK inhibitors, but, unfortunately, the response to these inhibitors is variable due to tumor resistance. Identifying genetic modifiers involved in resistance toward MEK-targeted therapy may assist in the development of new therapeutic strategies, enhancing treatment response and patient survival. Our whole genome CRISPR-Cas9 knockout s...
Source: Pigment Cell and Melanoma Research - September 24, 2019 Category: Cytology Authors: Nagler A, Vredevoogd DW, Alon M, Cheng PF, Trabish S, Kalaora S, Arafeh R, Goldin V, Levesque MP, Peeper DS, Samuels Y Tags: Pigment Cell Melanoma Res Source Type: research

Mitogen-activated protein kinase dependency in BRAF/RAS wild type melanoma: a rationale for combination inhibitors.
Abstract Inhibitors targeting the mitogen-activated protein kinase (MAPK) pathway and immune checkpoint molecules have dramatically improved the survival of patients with BRAFV600 -mutant melanoma. For BRAF/RAS wild type (WT) melanoma patients, however, immune checkpoint inhibitors remain the only effective therapeutic option with 40% of patients responding to PD-1 inhibition. In the present study, a large panel of 10 BRAFV600 -mutant and 13 BRAF/RAS WT melanoma cell lines was analyzed to examine MAPK dependency and explore the potential utility of MAPK inhibitors in this melanoma subtype. We now show that the maj...
Source: Pigment Cell and Melanoma Research - September 13, 2019 Category: Cytology Authors: Ming Z, Lim SY, Kefford RF, Rizos H Tags: Pigment Cell Melanoma Res Source Type: research

Endothelin-1 and α-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways.
Endothelin-1 and α-melanocortin have redundant effects on global genome repair in UV-irradiated human melanocytes despite distinct signaling pathways. Pigment Cell Melanoma Res. 2019 Sep 10;: Authors: Swope VB, Starner RJ, Rauck C, Abdel-Malek ZA Abstract Human melanocyte homeostasis is sustained by paracrine factors that reduce the genotoxic effects of ultraviolet radiation (UV), the major etiological factor for melanoma. The keratinocyte-derived endothelin-1 (End-1) and α-melanocyte stimulating hormone (α-MSH) regulate human melanocyte function, proliferation and survival, and enha...
Source: Pigment Cell and Melanoma Research - September 10, 2019 Category: Cytology Authors: Swope VB, Starner RJ, Rauck C, Abdel-Malek ZA Tags: Pigment Cell Melanoma Res Source Type: research

Differences in tumor initiation and progression of melanoma in the BrafCA ;Tyr-CreERT2;Ptenf/f model between male and female mice.
This article is protected by copyright. All rights reserved. PMID: 31449725 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 26, 2019 Category: Cytology Authors: Zhai Y, Haresi AJ, Huang L, Lang D Tags: Pigment Cell Melanoma Res Source Type: research

Evidence and impact of neutrophil extracellular traps in malignant melanoma.
This article is protected by copyright. All rights reserved. PMID: 31402559 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 12, 2019 Category: Cytology Authors: Schedel F, Mayer-Hain S, Pappelbaum KI, Metze D, Stock M, Goerge T, Loser K, Sunderkötter C, Luger TA, Weishaupt C Tags: Pigment Cell Melanoma Res Source Type: research

NRAS mutated melanoma: that's what we got so far.
Abstract NRAS mutation, occurring in about 20-30% of cutaneous melanomas, leads to activation of RAS-RAF-MAPK cascade and represents a clear distinct clinicopathological entity in melanoma. In contrast with BRAF mutant melanoma, no specific target therapies are available outside the setting of clinical trials. In the field of immunoncology, the predictive role of NRAS mutation with respect to checkpoint inhibitors treatment has not clearly established and deserves further investigation. At present, the standard treatment is the same as for BRAF wild type melanoma. Ongoing trials are exploring novel combination str...
Source: Pigment Cell and Melanoma Research - August 12, 2019 Category: Cytology Authors: Bertoli E, Giavarra M, Vitale MG, Minisini AM Tags: Pigment Cell Melanoma Res Source Type: research

Body site-specific genetic effects influence naevus count distribution in women.
This article is protected by copyright. All rights reserved. PMID: 31403758 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 12, 2019 Category: Cytology Authors: Visconti A, Ribero S, Sanna M, Spector TD, Bataille V, Falchi M Tags: Pigment Cell Melanoma Res Source Type: research

Cutaneous pharmacologic cAMP induction induces melanization of the skin and improves recovery from ultraviolet injury in melanocortin 1 receptor-intact or heterozygous skin.
This article is protected by copyright. All rights reserved. PMID: 31398282 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 9, 2019 Category: Cytology Authors: Bautista RF, Carter KM, Jarrett SG, Napier D, Wakamatsu K, Ito S, D'Orazio JA Tags: Pigment Cell Melanoma Res Source Type: research

A ROCK inhibitor promotes keratinocyte survival and paracrine secretion, enhancing establishment of primary human melanocytes and melanocyte-keratinocyte co-cultures.
This article is protected by copyright. All rights reserved. PMID: 31386789 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - August 6, 2019 Category: Cytology Authors: Mi J, Feng Y, Wen J, Su Y, Xu L, Zu T, Liu C, Fisher DE, Wu X Tags: Pigment Cell Melanoma Res Source Type: research

Excimer stamp test distinguishing between nevus depigmentosus and segmental vitiligo.
This article is protected by copyright. All rights reserved. PMID: 31365787 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 31, 2019 Category: Cytology Authors: Bae JM, Eun SH, Kim YH, Park JH, Hann SK Tags: Pigment Cell Melanoma Res Source Type: research

Neoadjuvant BRAF-targeted therapy in regionally advanced and oligometastatic melanoma.
CONCLUSION: Neoadjuvant BRAF-targeted therapy is associated with a high pCR rate in patients with stage III-IV melanoma, which may correlate with improved RFS and OS. This article is protected by copyright. All rights reserved. PMID: 31329344 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 22, 2019 Category: Cytology Authors: Eroglu Z, Eatrides J, Naqvi SMH, Kim Y, Rich J, Babacan NA, Brohl AS, Markowitz J, Sarnaik A, Zager J, Khushalani NI, Sondak VK, Messina J Tags: Pigment Cell Melanoma Res Source Type: research

Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival.
This article is protected by copyright. All rights reserved. PMID: 31323160 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 19, 2019 Category: Cytology Authors: Ferguson J, Wilcock DJ, McEntegart S, Badrock AP, Levesque M, Dummer R, Wellbrock C, Smith MP Tags: Pigment Cell Melanoma Res Source Type: research

Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells.
This article is protected by copyright. All rights reserved. PMID: 31310445 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 16, 2019 Category: Cytology Authors: Böhme I, Bosserhoff A Tags: Pigment Cell Melanoma Res Source Type: research

IsomiRs and tRNA-derived Fragments are Associated with Metastasis and Patient Survival in Uveal Melanoma.
This article is protected by copyright. All rights reserved. PMID: 31283110 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 8, 2019 Category: Cytology Authors: Londin E, Magee R, Shields CL, Lally SE, Sato T, Rigoutsos I Tags: Pigment Cell Melanoma Res Source Type: research

Discoidin Domain Receptors: A promising target in melanoma.
This article is protected by copyright. All rights reserved. PMID: 31271515 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 4, 2019 Category: Cytology Authors: Reger de Moura C, Battistella M, Sohail A, Caudron A, Feugeas JP, Podgorniak MP, Pages C, Mazouz Dorval S, Marco O, Menashi S, Fridman R, Lebbé C, Mourah S, Jouenne F Tags: Pigment Cell Melanoma Res Source Type: research

Tyrosinase-catalyzed oxidation of resveratrol produces a highly reactive ortho-quinone: implications for melanocyte toxicity.
This article is protected by copyright. All rights reserved. PMID: 31264351 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - July 2, 2019 Category: Cytology Authors: Ito S, Fujiki Y, Matsui N, Ojika M, Wakamatsu K Tags: Pigment Cell Melanoma Res Source Type: research

Supporting women in science at PCMR.
PMID: 31210012 [PubMed - in process] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - June 19, 2019 Category: Cytology Authors: T Weeraratna A, Elizabeth Patton E Tags: Pigment Cell Melanoma Res Source Type: research

MITF controls the TCA cycle to modulate the melanoma hypoxia response.
This article is protected by copyright. All rights reserved. PMID: 31207090 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - June 17, 2019 Category: Cytology Authors: Louphrasitthiphol P, Ledaki I, Chauhan J, Falletta P, Siddaway R, Buffa FM, Mole DR, Soga T, Goding CR Tags: Pigment Cell Melanoma Res Source Type: research

Role of MIA (melanoma inhibitory activity) in melanocyte senescence.
This article is protected by copyright. All rights reserved. PMID: 31172672 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - June 6, 2019 Category: Cytology Authors: Feuerer L, Lamm S, Henz I, Kappelmann-Fenzl M, Haferkamp S, Meierjohann S, Hellerbrand C, Kuphal S, Bosserhoff AK Tags: Pigment Cell Melanoma Res Source Type: research

NGS-based targeted resequencing identified rare subtypes of albinism; providing accurate molecular diagnosis for Japanese patients with albinism.
This article is protected by copyright. All rights reserved. PMID: 31141302 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - May 29, 2019 Category: Cytology Authors: Okamura K, Hayashi M, Abe Y, Kono M, Nakajima K, Aoyama Y, Nishigori C, Ishimoto H, Ishimatsu Y, Nakajima M, Hozumi Y, Suzuki T Tags: Pigment Cell Melanoma Res Source Type: research

Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an amelanistic morph.
This article is protected by copyright. All rights reserved. PMID: 31131985 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - May 27, 2019 Category: Cytology Authors: Kratochwil ACF, Urban S, Meyer A Tags: Pigment Cell Melanoma Res Source Type: research

Comprehensive Analysis of Spectral Distribution of a large cohort of Chinese Patients with Non-syndromic Oculocutaneous Albinism Facilitates Genetic Diagnosis.
This study shows that OCA1 is the most common (75/114) and OCA2 ranks the second most common (16/114) in Chinese. 99 patients of our cohort were caused by variants of all the known nsOCA genes. Cutaneous phenotypes of OCA1, OCA2, OCA4 patients were shown in this study. The second OCA6 case in China was identified here. These data expand the spectrum of OCA variants as well phenotype, and facilitate clinical implement of Chinese OCA patients. This article is protected by copyright. All rights reserved. PMID: 31077556 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - May 11, 2019 Category: Cytology Authors: Zhong Z, Gu L, Zheng X, Ma N, Wu Z, Duan J, Zhang J, Chen J Tags: Pigment Cell Melanoma Res Source Type: research

The TYRP1-mediated protection of human tyrosinase activity does not involve stable interactions of tyrosinase domains.
This article is protected by copyright. All rights reserved. PMID: 31077632 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - May 11, 2019 Category: Cytology Authors: Dolinska MB, Wingfield PT, Young KL, Sergeev YV Tags: Pigment Cell Melanoma Res Source Type: research

IL-17A is not a treatment target in progressive vitiligo.
This article is protected by copyright. All rights reserved. PMID: 31063266 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - May 7, 2019 Category: Cytology Authors: Speeckaert R, Mylle S, van Geel N Tags: Pigment Cell Melanoma Res Source Type: research

The next generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.
This article is protected by copyright. All rights reserved. PMID: 31063649 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - May 7, 2019 Category: Cytology Authors: Erkes DA, Field CO, Capparelli C, Tiago M, Purwin TJ, Chervoneva I, Berger AC, Hartsough EJ, Villanueva J, Aplin AE Tags: Pigment Cell Melanoma Res Source Type: research

Life as Editor.
PMID: 31006994 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - April 21, 2019 Category: Cytology Authors: Setaluri V Tags: Pigment Cell Melanoma Res Source Type: research

A novel CDKN2A variant (p16L117P ) in a patient with familial and multiple primary melanomas.
This article is protected by copyright. All rights reserved. PMID: 31001908 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - April 18, 2019 Category: Cytology Authors: Li C, Liu T, Liu B, Hernandez R, Facelli JC, Grossman D Tags: Pigment Cell Melanoma Res Source Type: research

Malignant melanoma with areas of rhabdomyosarcomatous differentiation arising in a giant congenital nevus with RAF1 gene fusion.
This article is protected by copyright. All rights reserved. PMID: 30945443 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - April 4, 2019 Category: Cytology Authors: Baltres A, Salhi A, Houlier A, Pissaloux D, Tirode F, Haddad V, Karanian M, Ysmail Dahlouk S, Boukendakdji F, Dahlouk D, Allaoua F, Metref M, Djeridane A, Fraitag S, de la Fouchardiere A Tags: Pigment Cell Melanoma Res Source Type: research

Validation of a Physicians Global Assessment (PGA) tool for vitiligo extent: results of an international vitiligo expert meeting.
This article is protected by copyright. All rights reserved. PMID: 30945409 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - April 3, 2019 Category: Cytology Authors: van Geel N, Wolkerstorfer A, Ezzedine K, Pandya AG, Bekkenk M, Grine L, Van Belle S, Lommerts JE, Hamzavi I, Harris JE, Eleftheriadou V, Esmat S, Kang HY, Kumarasinghe P, Lan CE, Parsad D, Raboobee N, Xiang LF, Suzuki T, Prinsen CA, Taieb A, Picardo M, Sp Tags: Pigment Cell Melanoma Res Source Type: research

Larval but not adult xanthophore pigmentation in zebrafish requires GTP cyclohydrolase 2 (gch2) function.
This article is protected by copyright. All rights reserved. PMID: 30896066 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 21, 2019 Category: Cytology Authors: Lister JA Tags: Pigment Cell Melanoma Res Source Type: research

Oral Levodopa rescues retinal morphology and visual function in a murine model of human albinism.
This article is protected by copyright. All rights reserved. PMID: 30851223 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 9, 2019 Category: Cytology Authors: Lee H, Scott J, Griffiths H, Self JE, Lotery A Tags: Pigment Cell Melanoma Res Source Type: research

Dyspigmented Hypertrophic Scars: beyond Skin Color.
This article is protected by copyright. All rights reserved. PMID: 30849202 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 8, 2019 Category: Cytology Authors: Alkhalil A, Carney BC, Travis TE, Muhie S, Miller SA, Ramella-Roman JC, Ghassemi P, Hammamieh R, Jett M, Moffatt LT, Shupp JW Tags: Pigment Cell Melanoma Res Source Type: research

The 308-nm excimer laser treatment does not increase the risk of skin cancer in patients with vitiligo: A population-based retrospective cohort study.
In conclusion, EL treatment would not increase the risks of premalignant skin lesions and skin cancers in patients with vitiligo. Based on our results, EL is likely to be a safe treatment option for patients with localized vitiligo. This article is protected by copyright. All rights reserved. PMID: 30849210 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 8, 2019 Category: Cytology Authors: Bae JM, Eun SH, Oh SH, Shin JH, Kang HY, Kim KH, Lee SC, Choi CW Tags: Pigment Cell Melanoma Res Source Type: research

Induced pluripotent stem cells-derived melanocyte precursor cells undergoing differentiation into melanocytes.
This article is protected by copyright. All rights reserved. PMID: 30843370 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2019 Category: Cytology Authors: Hosaka C, Kunisada M, Koyanagi-Aoi M, Masaki T, Takemori C, Taniguchi-Ikeda M, Aoi T, Nishigori C Tags: Pigment Cell Melanoma Res Source Type: research

SOX10 regulates multiple genes to direct eumelanin vs. pheomelanin production in domestic rock pigeon.
This article is protected by copyright. All rights reserved. PMID: 30838786 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2019 Category: Cytology Authors: Domyan ET, Hardy J, Wright T, Frazer C, Daniels J, Kirkpatrick J, Kirkpatrick J, Wakamatsu K, Hill JT Tags: Pigment Cell Melanoma Res Source Type: research

A dual pathway inhibition strategy using BKM120 combined with vemurafenib is poorly tolerated in BRAF V600E/K mutant advanced melanoma.
This article is protected by copyright. All rights reserved. PMID: 30801911 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 24, 2019 Category: Cytology Authors: Algazi AP, Rotow J, Posch C, Ortiz-Urda S, Pelayo A, Munster PN, Daud A Tags: Pigment Cell Melanoma Res Source Type: research

Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl.
This article is protected by copyright. All rights reserved. PMID: 30791235 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 21, 2019 Category: Cytology Authors: Bertolesi GE, Zhijia Zhang J, McFarlane S Tags: Pigment Cell Melanoma Res Source Type: research

Incidence, features and management of radionecrosis in melanoma patients treated with cerebral radiotherapy and anti-PD-1 antibodies.
CONCLUSIONS: Radionecrosis is a significant toxicity in longer-term melanoma survivors with MBM treated with anti-PD-1 and radiotherapy. Identification of those at risk of radionecrosis who may avoid radiotherapy is required. SIGNIFICANCE: Many patients with melanoma brain metastases receive radiotherapy and anti-PD-1 therapy, and this study demonstrates that approximately one fifth of those who survive beyond one year develop radionecrosis, which causes symptoms that can be difficult to manage. Recent data demonstrate high activity of anti-PD-1-based therapy in patients with brain metastases, such that some patients ...
Source: Pigment Cell and Melanoma Research - February 15, 2019 Category: Cytology Authors: Pires da Silva I, Glitza IC, Haydu LE, Johnpulle R, Banks PD, Grass GD, Goldinger SM, Smith JL, Everett AS, Koelblinger P, Roberts-Thomson R, Millward M, Atkinson VG, Guminski A, Kapoor R, Conry RM, Carlino MS, Wang W, Shackleton MJ, Eroglu Z, Lo S, Hong Tags: Pigment Cell Melanoma Res Source Type: research

Mechanism of action of 4-substituted phenols to induce vitiligo and anti-melanoma immunity.
This article is protected by copyright. All rights reserved. PMID: 30767390 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 14, 2019 Category: Cytology Authors: Kammeyer A, Willemsen KJ, Ouwerkerk W, Bakker WJ, Ratsma D, Pronk SD, Smit NP, Luiten RM Tags: Pigment Cell Melanoma Res Source Type: research

Effect of early adverse events on response and survival outcomes of advanced melanoma patients treated with vemurafenib or vemurafenib plus cobimetinib: A pooled analysis of clinical trial data.
This study aimed to evaluate the impact of early adverse events on overall survival (OS), progression-free survival (PFS) and objective response within a pooled secondary analysis of participants treated with first-line vemurafenib or vemurafenib plus cobimetinib in the clinical trials BRIM3 and coBRIM. The study included 583 participants who received vemurafenib monotherapy and 247 who received vemurafenib plus cobimetinib. Adverse events requiring vemurafenib/cobimetinib dose adjustment within the first 28 days of therapy were significantly associated with OS (Hazard Ratio (HR) [95%CI]: Dose reduced/interrupted = 0.79 [0...
Source: Pigment Cell and Melanoma Research - February 13, 2019 Category: Cytology Authors: Hopkins AM, Van Dyk M, Rowland A, Sorich MJ Tags: Pigment Cell Melanoma Res Source Type: research

Nicotinamide as a chemopreventive therapy of skin cancers. Too much of good thing ?
This article is protected by copyright. All rights reserved. PMID: 30742742 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 11, 2019 Category: Cytology Authors: Ballotti R, Healy E, Bertolotto C Tags: Pigment Cell Melanoma Res Source Type: research

Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.
This article is protected by copyright. All rights reserved. PMID: 30712316 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 3, 2019 Category: Cytology Authors: Eroglu Z, Holmen SL, Chen Q, Khushalani NI, Amaravadi R, Thomas R, Ahmed KA, Tawbi H, Chandra S, Markowitz J, Smalley I, Liu JKC, Ann Chen Y, Najjar YG, Karreth FA, Abate-Daga D, Glitza IC, Sosman JA, Sondak VK, Bosenberg M, Herlyn M, Atkins MB, Kluger H, Tags: Pigment Cell Melanoma Res Source Type: research

Histopathologic variables differentially affect melanoma survival by age at diagnosis.
This article is protected by copyright. All rights reserved. PMID: 30706692 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - January 31, 2019 Category: Cytology Authors: Mishra K, Barnhill RL, Paddock LE, Fine JA, Berwick M Tags: Pigment Cell Melanoma Res Source Type: research

Pathology of spontaneous and immunotherapy-induced tumor regression in a murine model of melanoma.
This article is protected by copyright. All rights reserved. PMID: 30702217 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - January 31, 2019 Category: Cytology Authors: Blenman KRM, Wang J, Cowper S, Bosenberg M Tags: Pigment Cell Melanoma Res Source Type: research

Biomarker discovery analysis: Alterations in p14, p16, p53, and BAP1 expression in nevi, cutaneous melanoma, and metastatic melanoma.
This article is protected by copyright. All rights reserved. PMID: 30672662 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - January 23, 2019 Category: Cytology Authors: Sargen MR, Cloutier JM, Sarin KY, Rieger KE, Chu P, Swetter SM, Novoa RA Tags: Pigment Cell Melanoma Res Source Type: research