RNA M6A modification shaping cutaneous melanoma tumor microenvironment and predicting immunotherapy response
Pigment Cell Melanoma Res. 2024 Apr 16. doi: 10.1111/pcmr.13170. Online ahead of print.ABSTRACTRecent years have seen rising mortality rates linked to cutaneous melanoma (SKCM), despite advances in immunotherapy. Understanding RNA N6-methyladenosine (M6A) significance in SKCM is crucial for prognosis, tumor microenvironment (TME), immune cell presence, and immunotherapy efficacy. We analyzed 23 M6A regulators using SKCM samples from TCGA and GEO databases, identifying three M6A modification patterns linked to TME cell infiltration. Principal component analysis (PCA) yielded an M6A score for individual tumors, utilizing pat...
Source: Pigment Cell and Melanoma Research - April 16, 2024 Category: Cytology Authors: Yanhong Wu Hongying He Kairong Zheng Zhenxin Qin Naikun Cai Shuguang Zuo Xiao Zhu Source Type: research
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing
Pigment Cell Melanoma Res. 2024 Apr 13. doi: 10.1111/pcmr.13169. Online ahead of print.ABSTRACTMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, ...
Source: Pigment Cell and Melanoma Research - April 13, 2024 Category: Cytology Authors: Joseph W Palmer Nilesh Kumar Luye An Andrew C White M Shahid Mukhtar Melissa L Harris Source Type: research
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing
Pigment Cell Melanoma Res. 2024 Apr 13. doi: 10.1111/pcmr.13169. Online ahead of print.ABSTRACTMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, ...
Source: Pigment Cell and Melanoma Research - April 13, 2024 Category: Cytology Authors: Joseph W Palmer Nilesh Kumar Luye An Andrew C White M Shahid Mukhtar Melissa L Harris Source Type: research
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing
Pigment Cell Melanoma Res. 2024 Apr 13. doi: 10.1111/pcmr.13169. Online ahead of print.ABSTRACTMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, ...
Source: Pigment Cell and Melanoma Research - April 13, 2024 Category: Cytology Authors: Joseph W Palmer Nilesh Kumar Luye An Andrew C White M Shahid Mukhtar Melissa L Harris Source Type: research
Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing
Pigment Cell Melanoma Res. 2024 Apr 13. doi: 10.1111/pcmr.13169. Online ahead of print.ABSTRACTMelanocyte stem cells (McSCs) of the hair follicle are a rare cell population within the skin and are notably underrepresented in whole-skin, single-cell RNA sequencing (scRNA-seq) datasets. Using a cell enrichment strategy to isolate KIT+/CD45- cells from the telogen skin of adult female C57BL/6J mice, we evaluated the transcriptional landscape of quiescent McSCs (qMcSCs) at high resolution. Through this evaluation, we confirmed existing molecular signatures for qMcCS subpopulations (e.g., Kit+, Cd34+/-, Plp1+, Cd274+/-, Thy1+, ...
Source: Pigment Cell and Melanoma Research - April 13, 2024 Category: Cytology Authors: Joseph W Palmer Nilesh Kumar Luye An Andrew C White M Shahid Mukhtar Melissa L Harris Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Pigment Cell Melanoma Res. 2024 Apr 1. doi: 10.1111/pcmr.13168. Online ahead of print.ABSTRACTResearch on new ingredients that can prevent excessive melanin production in the skin while considering efficacy, safety but also environmental impact is of great importance to significantly improve the profile of existing actives on the market and avoid undesirable side effects. Here, the discovery of an innovative technology for the management of hyperpigmentation is described. High-throughput screening tests on a wide chemical diversity of molecules and in silico predictive methodologies were essential to design an original thi...
Source: Pigment Cell and Melanoma Research - April 1, 2024 Category: Cytology Authors: Peggy Sextius Emilie Warrick Am élie Prévot-Guéguiniat Guillaume Lereaux Florence Boirre Ludwig Baux Safa Ben Hassine Jie Qiu Xiaoming Huang Jinzhu Xu S ébastien Grégoire Shosuke Ito Kazumasa Wakamatsu Xavier Marat Source Type: research
Characterization of PRAME immunohistochemistry reveals lower expression in pediatric melanoma compared to adult melanoma
Pigment Cell Melanoma Res. 2024 Mar 20. doi: 10.1111/pcmr.13167. Online ahead of print.ABSTRACTPediatric melanomas are rare tumors that have clinical and histological differences from adult melanomas. In adult melanoma, the immunohistochemical marker PRAME is increasingly employed as a diagnostic adjunct. PRAME is also under investigation as a target structure for next-generation immunotherapies including T-cell engagers. Little is known about the characteristics of PRAME expression in pediatric melanoma. In this retrospective study, samples from 25 pediatric melanomas were compared with control groups of melanomas in youn...
Source: Pigment Cell and Melanoma Research - March 21, 2024 Category: Cytology Authors: Stephan Forchhammer Valentin Aebischer Daniela Lenders Christian M Seitz Christopher Schroeder Alexandra Liebmann Michael Abele Hannah Wild Ewa Bien Malgorzata Krawczyk Dominik T Schneider Ines B Brecht Lukas Flatz Matthias Hahn Source Type: research
