Photobiomodulation increases cell viability via AKT activation in an in vitro model of diabetes induced by glucose neurotoxicity
AbstractPeripheral neuropathy (PN) is a serious complication of diabetes mellitus (DM) and is known to be resistant to conventional treatment. Photobiomodulation (PBM) is demonstrated to be effective in treating PN and in protecting nerve fiber damage. To better understand the mechanisms underlying the regenerative effects of PBM on diabetic neuropathy, we conducted a study in an in vitro model of diabetes induced by glucose neurotoxicity. Neuro 2A cells (1  × 104 cells/ well; N2A) were cultured in Minimum Essential Medium (MEM) supplemented with high glucose concentrations (100  mM) for 48 h ...
Source: Lasers in Medical Science - June 20, 2019 Category: Laser Surgery Source Type: research

Prolonged post-stimulation response induced by 980-nm infrared neural stimulation in the rat primary motor cortex
AbstractThe post-stimulation response of neural activities plays an important role to evaluate the effectiveness and safety of neural modulation techniques. Previous studies have established the capability of infrared neural modulation (INM) on neural firing regulation in the central nervous system (CNS); however, the dynamic neural activity after the laser offset has not been well characterized yet. We applied 980-nm infrared diode laser light to irradiate the primary motor cortex of rats, and tungsten electrode was inserted to record the single-unit activity of neurons at the depth of 800 –1000 μm (layer V ...
Source: Lasers in Medical Science - June 20, 2019 Category: Laser Surgery Source Type: research

Effects of low level laser therapy in cancer cells —a systematic review of the literature
AbstractThe aim of the present study was to conduct a systematic review regarding the use of photobiomodulation (PBM) therapy in tumoral cells, addressing the different types of lasers and parameters used. An electronic search was performed in PubMed/MEDLINE, Cochrane Library, and EMBASE databases. The inclusion criteria were being an in vitro study, with tumoral cells, and have at least one group of treatment with low-power laser and a control group (without treatment). Were excluded studies that used only non-carcinogenic cells, in vivo studies, studies that used high-power laser or the association with photosensitizers....
Source: Lasers in Medical Science - June 17, 2019 Category: Laser Surgery Source Type: research

Recalcitrant viral warts treated with photodynamic therapy methyl aminolevulinate and red light (630  nm): a case series of 51 patients
(Source: Lasers in Medical Science)
Source: Lasers in Medical Science - June 17, 2019 Category: Laser Surgery Source Type: research

Correction to: Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell ’s) palsy
The published version contains a mistake in Figure 1. Below is the correct figure. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - June 17, 2019 Category: Laser Surgery Source Type: research

Acute effect of photobiomodulation using light-emitting diodes (LEDs) on baroreflex sensitivity during and after constant loading exercise in patients with type 2 diabetes mellitus
AbstractTo evaluate the photobiomodulation (PBM) effect on the cardiovascular autonomic control, analyzed by baroreflex sensitivity (sequence method), during constant load exercise and recovery in diabetic men, we evaluated 11 men with type 2 diabetes (DM2) (40 –64 years). The constant workload exercise protocol (TECC) was performed on two different days, 14 days apart from each other, to guarantee PBM washout period. After PBM by light-emitting diode (LED) irradiation (150 J or 300 J or placebo), 10 min of rest (REST) was performed. After this peri od, the volunteer was positioned on a cyclo...
Source: Lasers in Medical Science - June 15, 2019 Category: Laser Surgery Source Type: research

Effects of muscular strength training and growth hormone (GH) supplementation on femoral bone tissue: analysis by Raman spectroscopy, dual-energy X-ray absorptiometry, and mechanical resistance
AbstractThe aim of the present study was to verify the effects of muscular strength training and growth hormone (GH) supplementation on femoral bone tissue by Raman spectroscopy (Raman), dual-energy X-ray absorptiometry (DXA), and mechanical resistance (F-max) analysis. A total of 40 male Wistar animals, 60  days old, were used. The animals were distributed into four groups: control (C), control with GH (GHC), muscular strength training (T), and muscular strength training with GH (GHT). Blood samples were collected for the quantification of creatine kinase (CK-MB) and the femurs were removed for analy sis by Raman, DX...
Source: Lasers in Medical Science - June 15, 2019 Category: Laser Surgery Source Type: research

Effects of photobiomodulation on muscle strength in post-menopausal women submitted to a resistance training program
AbstractThe aim of this study was to compare the effects of resistance training of low volume and high intensity with or without photobiomodulation (PBM) on muscle strength and functional performance in post-menopausal women. Thirty-four post-menopausal women were randomized into resistance training (RTG,n = 17) or resistance training plus PBM (PBMG,n = 17). Individuals from both groups received the same RT protocol consisting of leg-press 45°, front lat pulldown, leg curl, chest press, and squat performed in two sets of 10 repetitions with a workload of 75% of one repetition maximum (1RM), ...
Source: Lasers in Medical Science - June 14, 2019 Category: Laser Surgery Source Type: research

Diagnostic validity of the use of ICDAS II and DIAGNOdent pen verified by micro-computed tomography for the detection of occlusal caries lesions —an in vitro evaluation
AbstractThe aim of this study is to assess the extent of early carious lesions using the International Caries Detection and Assessment System (ICDAS) II and DIAGNOdent pen compared with microCT examination. Forty-eight molars and premolars were qualified for the study. The visual and the DIAGNOdent pen device examinations were carried out by two examiners. The actual extent of the lesions was determined using micro-CT examination. The optimal cutoff test value was determined using the Youden index. For the two methods, inter- and intra-examiner reproducibility was calculated using intraclass correlation coefficient. The se...
Source: Lasers in Medical Science - June 14, 2019 Category: Laser Surgery Source Type: research

Fractional CO 2 laser treatment for post-surgical lip scars in cleft lip and palate patients
AbstractPost-surgical scars of cleft lip patients can lead to abnormal lip activity, which causes deficient maxillary growth. The aim of the present study was to assess the effect of laser therapy on the appearance and electrical activity of the upper lip in cleft lip and palate patients. Twelve patients with cleft lip and palate participated in this study. All patients had surgically repaired the cleft lip at the age of about 3 –6 months. The lip scars underwent five fractional CO2 laser treatment sessions with a 4-week interval. Improvement of the quality of the skin texture was recorded according to quartile ...
Source: Lasers in Medical Science - June 11, 2019 Category: Laser Surgery Source Type: research

Intravenous laser wavelength radiation effect on LCAT, PON1, catalase, and FRAP in diabetic rats
AbstractThe main purpose of this study is to evaluate the effect of intravenous irradiation of different low-level laser wavelengths on the activity of lecithin-cholesterol acyltransferase (LCAT), paraoxonase (PON1), catalase, and ferric  reducing ability of plasma (FRAP) in diabetic rats. First, diabetes was induced in rats using streptozotocin (STZ). Enzymes’ activity was measured in the blood samples and compared before and after intravenous laser blood irradiation. We used four continuous-wave lasers—IR (λ = 808 nm), Red (λ = 638 nm), Green (λ&...
Source: Lasers in Medical Science - June 10, 2019 Category: Laser Surgery Source Type: research

Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective, randomized, controlled, evaluator-blinded trial
This study is aimed to compare the efficacy of low-fluence Q-switched Nd:YAG 1064-nm laser (LFQS 1064-nm) versus Q-switched Nd:YAG 532-nm laser (QS 532-nm) for the treatment of hyperpigmented lips. A randomized, controlled, evaluator-blinded study was conducted in thirty subjects. They were randomized into 2 groups. The first group was treated with five treatment sessions with a 2-week interval of LFQS 1064-nm laser while the second group was treated with a single session of QS 532-nm laser. The evaluation was conducted at baseline, 2  weeks of each post treatment, and 4 weeks after the last treatment session. Th...
Source: Lasers in Medical Science - June 8, 2019 Category: Laser Surgery Source Type: research

Comment on “Clinical study on the efficacy of LED phototherapy for pain control in an orthodontic procedure”
(Source: Lasers in Medical Science)
Source: Lasers in Medical Science - June 6, 2019 Category: Laser Surgery Source Type: research

Effects of red and near-infrared LED light therapy on full-thickness skin graft in rats
AbstractThe aim of the present study was to evaluate the in vivo response of different wavelengths (red and near-infrared) of light-emitting diode (LED) on full-thickness skin grafts (FTSG) in rats. Thirty rats were randomly allocated into three experimental groups: control group (C); red LED treated group (R); and near-infrared LED group (NIR). Skin grafts were irradiated daily for ten consecutive days, starting immediately after the surgery using a red (630  nm) or near-infrared (850 nm) LED. The results showed that the red wavelength LED significantly enhanced the skin graft score in relation to the NIR group ...
Source: Lasers in Medical Science - June 5, 2019 Category: Laser Surgery Source Type: research

Acute low-level laser therapy effects on peripheral muscle strength and resistance in patients with fibromyalgia
(Source: Lasers in Medical Science)
Source: Lasers in Medical Science - June 5, 2019 Category: Laser Surgery Source Type: research

Bioluminescence and near-infrared fluorescence imaging for detection of metastatic bone tumors
In this study, three different types of fluorophores such as D-luciferin, AkaLumine-HCl, and P800SO3 were compared to evaluate the progression of bone metastasis induced by MDA-MB-231 breast cancer cells in vivo. The fluorescent signals for D-luciferin, AkaLumine-HCl, and P800SO3 were differently detected in the chest and knee joint. In particular, the fluorescence signal of P800SO3 was clearly observed in a section of the ribs, where it pointed out fractured bone fragments by tumor mass. Moreover, the P800SO3 signal from the left knee joint also showed a small bone fragment in the distal femur and was highlighted in the p...
Source: Lasers in Medical Science - June 1, 2019 Category: Laser Surgery Source Type: research

Acute effect of photobiomodulation therapy on handgrip strength of chronic kidney disease patients during hemodialysis
In conclusion, in consensus with a recent systematic review, a single bout of the 60 J/arm was the best dose/response for increased strength of the small muscles (handgrip strength). In view of the increasing i mplementation of exercise programs during hemodialysis, the current study opens a new field for PBMT for CKD patients. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - May 18, 2019 Category: Laser Surgery Source Type: research

Modulation of exercise-induced muscular damage and hyperalgesia by different 630  nm doses of light-emitting diode therapy (LEDT) in rats
AbstractWe compared the acute effects of different doses of 630  nm light-emitting diode therapy (LEDT) on skeletal muscle inflammation and hyperalgesia in rats submitted to exercise-induced muscle damage (EIMD). Wistar rats were divided into five experimental groups (n = 5–8/group): sedentary control (CON); exercise + passive recovery (PR); and exercise + LEDT (1.2 J/cm2, 1.8  J; 4.2 J/cm2, 6.3  J; 10.0 J/cm2, 15  J). After 100 min of swimming, the rats in the LEDT groups were exposed to phototherapy on the triceps surae muscle. For mechanical hyperalgesia evalua...
Source: Lasers in Medical Science - May 18, 2019 Category: Laser Surgery Source Type: research

Impact of different color fiber sleeves on beam hazards of 532-nm laser and vaporization efficiency
AbstractThe 532-nm laser has become increasingly popular for the treatment of urologic diseases. However, laser beam will pose significant hazards for the health of surgeons. In order to reduce beam hazards during surgery, we compared the beam hazards of laser fiber with black sleeves to the traditional fiber with transparent sleeves, and the vaporization efficiency. A total of 18 porcine kidney specimens were vaporized in normal saline at a room temperature under 532-nm laser delivered through a 760- μm core diameter side firing fiber. Two groups were divided according to the color of fiber sleeves: the transparent and...
Source: Lasers in Medical Science - May 18, 2019 Category: Laser Surgery Source Type: research

Comment on “efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review”
(Source: Lasers in Medical Science)
Source: Lasers in Medical Science - May 18, 2019 Category: Laser Surgery Source Type: research

Correction to: Near infrared laser irradiation induces NETosis via oxidative stress and autophagy
The published online version contains mistake on the author names. The first names and family names were interchanged. Corrected names are shown in the author group section above. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - May 18, 2019 Category: Laser Surgery Source Type: research

Correction to: Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans
Unfortunately, there are two mistakes in the published article. The first mistake is found in the Results section, Clinical improvement subsection. The last sentence “There was no statistical difference between both sides (P=0.008).” should be corrected to “There was statistical difference between both sides (P=0.008).” (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - May 18, 2019 Category: Laser Surgery Source Type: research

Laser-assisted endoscopic lumbar foraminotomy for failed back surgery syndrome in elderly patients
AbstractElderly patients with failed back surgery syndrome (FBSS) or post-laminectomy foraminal stenosis have a higher risk of perioperative morbidity with extensive revision surgery. Thus, there is a need for safer and less invasive surgical options, such as laser-assisted endoscopic lumbar foraminotomy (ELF). A pin-point laser beam can allow precise tissue ablation and dissection in fibrotic adhesion tissues while preventing normal tissue injury. The present study aimed to describe the surgical technique of laser-assisted ELF and to evaluate the clinical outcomes of elderly patients with FBSS. Two-year follow-up data wer...
Source: Lasers in Medical Science - May 17, 2019 Category: Laser Surgery Source Type: research

Probing deep tissues with laser-induced thermotherapy using near-infrared light
AbstractOptically tunable gold nanoparticles have been widely used in research with near-infrared light as a means to enhance laser-induced thermal therapy since it capitalizes on nanoparticles ’ plasmonic heating properties. There have been several studies published on numerical models replicating this therapy in such conditions. However, there are several limitations on some of the models which can render the model unfaithful to therapy simulations. In this paper, two techniques of sim ulating laser-induced thermal therapy with a high-absorbing localized region of interest inside a phantom are compared. To validate...
Source: Lasers in Medical Science - May 17, 2019 Category: Laser Surgery Source Type: research

How standard deviation contributes to the validity of a LDF signal: a cohort study of 8  years of dental trauma
AbstractThe aim of this cohort study was to document the potential of laser Doppler flowmetry (LDF) for diagnosing tooth vitality in traumatized teeth in a population of 88 referred patients with dental trauma over a period of 8  years (2011–2018). The main reason to refer was tooth discoloration (26%), and the main trauma cause was a traffic injury (35%). Taking into account that referral for LDF is best given within the week after trauma, 66% of referrals were overdue. In 73% of cases, root canal treatment could be avo ided, and in 65%, the presence of a fixed orthodontic retainer showed beneficial for pulp re...
Source: Lasers in Medical Science - May 16, 2019 Category: Laser Surgery Source Type: research

Photobiomodulation for the treatment of periodontal pockets in patients with type 2 diabetes: 1-year results of a randomized clinical trial
This study investigated the local effect of photobiomodulation (PBM) for the treatment of periodontal pockets in patients with periodontitis and type 2 diabetes. Thirty-eight periodontal pockets presenting probing depth (PD) and clinical attachment level (CAL)  ≥ 5 mm were selected from 19 patients (two pockets/patient). The selected periodontal pockets were randomly assigned to receive mechanical debridement only (control group) or mechanical debridement with PBM (PBM group). Clinical measures, such as PD, CAL, bleeding on probing (BoP), and prese nce of supragingival biofilm (PI), were collected and...
Source: Lasers in Medical Science - May 15, 2019 Category: Laser Surgery Source Type: research

Anti – Trypanosoma cruzi effect of the photodynamic antiparasitic chemotherapy using phenothiazine derivatives as photosensitizers
AbstractChagas disease is endemic in Latin America and increasingly found in non-endemic countries. Its treatment is limited due to the variable efficacy and several side effects of benznidazole. Photodynamic antimicrobial chemotherapy (PACT) may be an attractive approach for treating Chagas disease. Here, the trypanocidal activity of PACT was investigated in vitro using phenothiazine derivatives. The cytotoxicity of both, methylene blue (MB) and toluidine blue (TBO), was determined on macrophages cultures using AlamarBlue method. The trypanocidal activity of the two photosensitizers was initially evaluated by determining ...
Source: Lasers in Medical Science - May 12, 2019 Category: Laser Surgery Source Type: research

Complementary low-level laser therapy for breast cancer-related lymphedema: a pilot, double-blind, randomized, placebo-controlled study
AbstractThis pilot, double-blind, randomized, placebo-controlled study is aimed at evaluating the effectiveness of low-level laser therapy (LLLT) as a complementary treatment to complete decongestive therapy (CDT) treating lymphedema among breast cancer patients for 12  months post-intervention. Study population was breast cancer patients who were diagnosed and referred to lymphedema clinic for CDT. Participants (n = 22) were randomized and assigned into either an active laser intervention group or an inactive laser placebo-control group. Active LLLT was administered to participants twice a week at the b...
Source: Lasers in Medical Science - May 11, 2019 Category: Laser Surgery Source Type: research

Utilizing 808  nm laser for sensitizing of melanoma tumors to megavoltage radiation therapy
In this study, the therapeutic effect of 808  nm laser therapy was investigated on B16-F10 melanoma tumor growth and tumor-bearing mice survival time. In addition, as laser can destroy melanin as the main cause of melanoma radioresistance, the effect of laser administration to enhance radiation therapy efficacy at B16-F10 cancer cells was eva luated in vitro and in vivo. Laser therapy (1 W/cm2 × 4 min) could cause significant (P 
Source: Lasers in Medical Science - May 10, 2019 Category: Laser Surgery Source Type: research

Near-infrared irradiation of the thyroid area: effects on weight development and thyroid and parathyroid secretory patterns
This study evaluates possible changes in weight and the secretory patterns of the thyroid and parathyroid glands irradiated with a 780-nm light-emitting diode (LED) source under conditions allowing their identification in an animal model. The use of near-infrared light sources to detect the parathyroid glands has been a subject of research due to the benefit provided to patients undergoing thyroid and parathyroid surgery. However, few studies have explored possible changes in weight and the secretory patterns of the glands when subjected to light stimulation. Thirty-two male Wistar rats were divided into two groups and sub...
Source: Lasers in Medical Science - May 6, 2019 Category: Laser Surgery Source Type: research

The study of killing effect and inducing apoptosis of 630-nm laser on lung adenocarcinoma A549 cells mediated by hematoporphyrin derivatives in vitro
AbstractTo investigate the killing effect and inducing apoptosis of 630-nm laser mediated by hematoporphyrin derivatives (HPD) on human lung adenocarcinoma A549 cells. The human lung adenocarcinoma A549 cells were incubated at random with different concentrations of HPD (5, 10, 12, 15, 20  μg/ml) for 4 h and then illuminated by 630-nm laser with different energy densities (25, 50, 75, 100 mW/cm2). And, meanwhile, the simple photosensitizer group, laser irradiation group, and blank control group were established. Then, CCK8, Hoechst 33258 staining, RT-PCR, and Western blot were employed. HPD-PDT proved no ...
Source: Lasers in Medical Science - May 2, 2019 Category: Laser Surgery Source Type: research

Efficacy of low-level laser therapy in pain management after root canal treatment or retreatment: a systematic review
AbstractThe aim of this study was to assess the effectiveness of low-level laser therapy (LLLT) for pain management after root canal treatment or retreatment. An electronic search for randomized controlled trials was conducted prior to November 2018, through PubMed, EMBASE, the Cochrane library (CENTRAL), and Web of Science. After filtering, seven articles were included, five related to root canal therapy (RCT) and two related to root canal retreatment (RCR). Six of the included studies presented a moderate risk of bias and a one low risk of bias, based on the Cochrane tool of risk of bias evaluation. The laser treatment i...
Source: Lasers in Medical Science - May 1, 2019 Category: Laser Surgery Source Type: research

Effects of laser-assisted thinning versus opening on clinical outcomes according to maternal age in patients with repeated implantation failure
In conclusion, LAT and LAO had similar clinical outcomes. Therefore, we did not find any evidence that LAT is superior to LAO. In fact, the patients ≥ 38 years of age who underwent LAO tended to have a lower abortion rate. Further study is necessary to confirm these results in a large r population. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - May 1, 2019 Category: Laser Surgery Source Type: research

Comparative study between the efficacy of fractional micro-needle radiofrequency and fractional CO 2 laser in the treatment of striae distensae
AbstractStriae distensae (SD) cause a cosmetic problem to many patients. Recently, fractional micro-needle radiofrequency (FMR) device has been introduced in treatment of SD. Also, fractional CO2 laser has been used as a resurfacing laser technique in the treatment of SD. The aim of our study was to assess and compare between the efficacy of FMR and fractional CO2 laser in treatment of SD. Seventeen female patients with SD were enrolled in this study. Detailed history was taken and dermatological examination was done to determine the type of striae, the location, and measurement of the width of the largest striae on each s...
Source: Lasers in Medical Science - May 1, 2019 Category: Laser Surgery Source Type: research

The effect of a single irradiation of low-level laser on nipple pain in breastfeeding women: a randomized controlled trial
AbstractPhotobiomodulation with low-level laser therapy (PBM-LLLT) has been introduced as a new tool to relieve nipple pain and repair nipple damage in breastfeeding women; however, evidence is needed to assess its effectiveness. The aim was to evaluate the effect of a single application of PBM-LLLT for breastfeeding women with nipple pain and damage; side effects were also collected. We conducted a randomized double-blinded controlled trial with women with nipple damage who were exclusively breastfeeding and rooming-in at Amparo Maternal maternity service, S ão Paulo, Brazil (May 2016 to May 2017). Women were rando...
Source: Lasers in Medical Science - April 27, 2019 Category: Laser Surgery Source Type: research

Early intervention with pulse dye and CO 2 ablative fractional lasers to improve cutaneous scarring post-lumpectomy: a randomized controlled trial on the impact of intervention on final cosmesis
AbstractLight-based modalities appear to be effective for ameliorating surgical scar appearance; however, protocols for achieving such outcomes have yet to be established. We studied the safety and efficacy of a combination of pulsed dye laser (PDL) and fractional ablative CO2 laser (FACL) for the attenuation of post-lumpectomy scarring. We conducted a prospective, evaluator-blinded, comparative split-scar study in post-lumpectomy patients. One-half of the scar was treated with three sessions of 595-nm PDL and FACL at 1-month intervals, starting within 6  weeks after suture removal. The entire scar was also treated wi...
Source: Lasers in Medical Science - April 26, 2019 Category: Laser Surgery Source Type: research

Fractional carbon dioxide laser and topical tioconazole in the treatment of fingernail onychomycosis
This study aimed to evaluate the role of fractional CO2 laser and topical tioconazole 28% nail lacquer in the treatment of fingernail onychomycosis, as sole treatment modalities and in combination. Thirty patients with culture-proven onychomycosis were included and randomly divided into three equal groups. Laser group received six fractional carbon dioxide (CO2) laser sessions at monthly intervals; topical group received topical tioconazole 28% nail lacquer twice daily for 6  months, and combined group received six fractional CO2 laser sessions at monthly intervals with topical tioconazole twice daily for 6  mont...
Source: Lasers in Medical Science - April 25, 2019 Category: Laser Surgery Source Type: research

Are the ergogenic effects of photobiomodulation therapy age-dependent? A randomized double-blinded placebo-controlled trial
(Source: Lasers in Medical Science)
Source: Lasers in Medical Science - April 25, 2019 Category: Laser Surgery Source Type: research

Transcranial near-infrared photobiomodulation could modulate brain electrophysiological features and attentional performance in healthy young adults
AbstractThe aim of the present study was to investigate the electrophysiological effects of the photobiomodulation (PBM) by the quantitative electroencephalography (qEEG) as a diagnostic method. The neurotherapeutic potential of transcranial PBM has been recently investigated in preclinical and clinical studies. According to the PBM mechanisms of action on increasing the cerebral blood flow and the neuronal firing, a change may occur in cortical electrical activity after transcranial PBM that could be revealed in qEEG. A total of 30 participants (15 males and 15 females) were included in this experimental study in a conven...
Source: Lasers in Medical Science - April 22, 2019 Category: Laser Surgery Source Type: research

Dual-wavelength erbium-doped fluoride fiber laser
AbstractThe laser source with 3  μm/2 μm output wavelength has many application prospects in clinical medicine, photoelectric countermeasure, and scientific research measurement. An Er3+ doped ZBLAN fiber laser with output wavelength of 2  .8 μm and 1 .6 μm is experimentally studied. By setting the pump power to 5 W, a continuous dual-wavelength output with a central wavelength of 2.803 μm and 1.61 μm is obtained and the corresponding maximum output power is 362.4 mW and 108.6 mW. The slope efficiency is 12.1% and 4.94% respectively. What’s more...
Source: Lasers in Medical Science - April 17, 2019 Category: Laser Surgery Source Type: research

New concept for treating urinary incontinence after radical prostatectomy with radiofrequency: phase 1 clinical trial
AbstractTo describe the clinical response and side effects of radiofrequency treatment in patients with urinary incontinence after radical prostatectomy. This is a phase 1 clinical trial with 10 men up to 65  years of age who had urinary incontinence after radical prostatectomy, post void residual volume
Source: Lasers in Medical Science - April 15, 2019 Category: Laser Surgery Source Type: research

Label-free diagnosis of lung cancer with tissue-slice surface-enhanced Raman spectroscopy and statistical analysis
This study sheds new light on the general applicability of SERS analysis of tissue slices in clinical trials. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - April 13, 2019 Category: Laser Surgery Source Type: research

Effects of photobiomodulation in the treatment of fractures: a systematic review and meta-analysis of randomized clinical trials
AbstractSeveral therapeutic strategies have been proposed to optimize the conventional treatment of fractures. Photobiomodulation (PBM) appears to help reduce pain and control inflammation, and it also accelerates bone repair. This systematic review aimed to evaluate the effectiveness and safety of PBM with low-level laser therapy (LLLT) in the bone fracture healing process. We included randomized controlled trials (RCTs) comparing the effects of PBM with those of any other intervention in adults with lower or upper limb bone fractures. The primary outcomes investigated were pain reduction, radiographic healing, and advers...
Source: Lasers in Medical Science - April 13, 2019 Category: Laser Surgery Source Type: research

A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia
AbstractFractional 1550-nm erbium-glass (Er:Glass) laser therapy is effective in inducing hair regrowth. Combining fractional Er:Glass laser therapy with topical minoxidil may yield therapeutic benefits for patients with androgenetic alopecia (AGA). To compare the efficacy and safety of fractional Er:Glass laser used in combination with topical 5% minoxidil versus 5% minoxidil alone for the treatment of male AGA, 30 men with AGA were randomized to 24  weeks of split-scalp treatment using fractional Er:Glass laser and 5% minoxidil on one side (combined therapy) or 5% minoxidil alone on the other side (monotherapy). The...
Source: Lasers in Medical Science - April 13, 2019 Category: Laser Surgery Source Type: research

Photobiomodulation-induced analgesia in experimental temporomandibular disorder involves central inhibition of fractalkine
AbstractTemporomandibular disorder (TMD) is a collective term that encompasses a set of clinical problems that affect the masticatory muscles, the temporomandibular joint, and associated structures. Despite their high clinical prevalence, the mechanisms of chronic craniofacial muscle pain are not yet well understood. Treatments for TMD pain relief and control should be minimally invasive, reversible, and conservative. Photobiomodulation (PBM) is a promising option once it is known to inhibit inflammatory response and to relief painful symptoms. Herein, the effects of PBM (660  nm, 30 mW, 16 J/cm2, 0.2  ...
Source: Lasers in Medical Science - April 10, 2019 Category: Laser Surgery Source Type: research

A transient protective effect of low-level laser irradiation against disuse-induced atrophy of rats
AbstractSatellite cells, a population of skeletal muscular stem cells, are generally recognized as the main and, possibly, the sole source of postnatal muscle regeneration. Previous studies have revealed the potential of low-level laser (LLL) irradiation in promoting satellite cell proliferation, which, thereby, boosts the recovery of skeletal muscle from atrophy. The purpose of this study is to investigate the beneficial effect of LLL on disuse-induced atrophy. The optimal irradiation condition of LLL (808  nm) enhancing the proliferation of Pax7+ve cells, isolated from tibialis anterior (TA) muscle, was examined and...
Source: Lasers in Medical Science - April 4, 2019 Category: Laser Surgery Source Type: research

Ultraviolet A/blue light-emitting diode therapy for vulvovaginal candidiasis: a case presentation
AbstractVulvovaginal candidiasis (VVC) is a frequent infection of the female genitourinary tract. It is considered the second most common genital infection in women, after bacterial vaginosis. VVC is treated with oral or topical azole derivatives. However, these agents may lead to adverse reactions and their chronic use might lead to resistance to antifungal agents. Given that the ultraviolet A/blue light-emitting diode (LED) is an electromagnetic radiation source with antimicrobial properties, it is hypothesized that this resource may be a non-drug alternative to the treatment of vulvovaginitis. A technical/experimental s...
Source: Lasers in Medical Science - April 3, 2019 Category: Laser Surgery Source Type: research

Effect of quality-switched laser exposure in patients with history of edible gold consumption
AbstractInjectable gold is known to deposit in the dermis for life, and such patients are at risk of developing chrysiasis post-laser exposure. It is unknown if patients with history of edible gold consumption would develop a similar reaction after quality-switched laser exposure. Our aim is to assess if patients with history of edible gold consumption develop chrysiasis after quality-switched laser exposure. This is a proof of concept pilot study conducted between September 2017 and September 2018 at two dermatology clinics in Riyadh, Saudi Arabia. Adult patients who have history of edible gold consumption were recruited ...
Source: Lasers in Medical Science - April 3, 2019 Category: Laser Surgery Source Type: research

Improved detection of subgingival calculus by laser fluorescence over differential reflectometry
This study compared the performance of LF using the KEY3 laser system versus DR using the DetecTar system under controlled laboratory conditions designed to simulate clinical conditions as much as possible. A total of 30 extracted human posterior teeth were set in an anatomical configuration in stone typodonts with impression material replicating the periodontal soft tissues. LF was more accurate than DR (76.2% vs. 68.2%) and gave higher reproducibility (Bangdiwala ’s B statistic 0.71 vs. 0.54). The better performance of LF makes it the preferred option of the two methods for detection of subgingival dental calculus....
Source: Lasers in Medical Science - April 2, 2019 Category: Laser Surgery Source Type: research

Photobiomodulation with 808-nm diode laser light promotes wound healing of human endothelial cells through increased reactive oxygen species production stimulating mitochondrial oxidative phosphorylation
AbstractPhotobiomodulation of cells using near-infrared (NIR) monochromatic light can affect cell functions such as proliferation, viability, and metabolism in a range of cell types. Evidence for the effects of near-infrared light on endothelial cells has been reported, but the studies were mainly performed using VIS light emitted by low-energy lasers, because NIR wavelengths seemed negatively stimulate these cells. Cell viability, free radical-induced oxidative stress, NF- κB activation, nitric oxide release, mitochondrial respiration, and wound healing repair were assessed in human endothelial cells (HECV) irradiat...
Source: Lasers in Medical Science - March 16, 2019 Category: Laser Surgery Source Type: research