Retrospective Analysis of Efgartigimod Use in Patients with Double-seronegative Generalized Myasthenia Gravis: A Case Series
Myasthenia gravis (MG), an autoimmune disease caused by autoantibodies that target proteins at the neuromuscular junction (NMJ), leads to impairment in synaptic transmission at the NMJ, resulting in variable weakness and skeletal muscle fatigability in this disease [1]. MG is classified based on clinical phenotype and type of autoantibodies involved. Most patients (75% –80%) are seropositive for antibodies against acetylcholine receptor (AChR), which consist primarily of IgG1 and IgG3 subtypes; their binding reduces the number and function of AChRs. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - April 23, 2024 Category: Neurology Authors: Kazuhiro Horiuchi, Shuntaro Nakamura, Kazuki Yamada, Takashi Inoue, Kei Oiwa Tags: Case report Source Type: research
Emerging Therapeutics in Chronic Urticaria
Chronic urticaria (CU) is a common and long-lasting mast cell-mediated skin disease associated with psychiatric and autoimmune comorbidities, high economic costs, and considerable impact on quality of life. Available therapies show limited efficacy in many CU patients, which may be related to distinct underlying pathophysiology. Targeted and disease-modifying treatments with higher and broader efficacy are needed and are under development for CU. These novel drugs, small molecules, and monoclonal antibodies target mast cells and their receptors, signaling pathways, or mediators and other immune cells. In this article, the ...
Source: Immunology and Allergy Clinics of North America - April 23, 2024 Category: Allergy & Immunology Authors: Melba Mu ñoz, Emek Kocatürk, Marcus Maurer, Pavel Kolkhir Source Type: research
EMAS position statement: Thyroid disease and menopause
Women experience menopause at a particular stage of their lifetime. On the other hand, subclinical hypothyroidism, mainly due to autoimmune thyroiditis, is a common endocrine disease in women during their reproductive years (the prevalence rate is 6 –10 %) [1] and is often present or arises during the menopausal transition. (Source: Maturitas)
Source: Maturitas - April 23, 2024 Category: Primary Care Authors: Gesthimani Mintziori, Stavroula Veneti, Kris Poppe, Dimitrios G. Goulis, Eleni Armeni, C. Tamer Erel, Ivan Fistoni ć, Timothy Hillard, Angelica Lindén Hirschberg, Blazej Meczekalski, Nicolás Mendoza, Alfred O. Mueck, Tommaso Simoncini, Petra Stute, Dor Tags: Original article Source Type: research
Hepatic and Extrahepatic Characteristics of Autoimmune Hepatitis: A 23-year Hospital-Based Cohort Study
ConclusionIn an Asian country endemic for viral hepatitis, the female-to-male and baseline cirrhosis rates of AIH patients were lower than expected, while over 60% of the patients eventually developed cirrhosis. The high posttherapy relapse rate warrants cautious monitoring, particularly for patients with high baseline Alk-p levels. Baseline age, cirrhosis status and ANA titers are crucial for outcomes. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - April 23, 2024 Category: Gastroenterology Source Type: research
Current status of fertility preservation in a Spanish tertiary public hospital: multidisciplinary approach and experience in over 1500 patients
ConclusionsThe increase in FP treatment reflects the implementation of reproductive counselling in oncology programmes. A multidisciplinary approach in a tertiary public hospital allows individualised FP treatment for each patient. In recent years, there has been a change in trend with the introduction of new indications for FP and a change in techniques due to their optimisation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Tofacitinib and peficitinib inhibitors of Janus kinase for autoimmune disease treatment: a quantum biochemistry approach
Phys. Chem. Chem. Phys., 2024, Advance Article DOI: 10.1039/D3CP06332A, PaperJackson L. Amaral, Naiara C. Lucredi, Victor L. B. Fran ça, Samuel J. M. Santos, Francisco F. Maia, Pablo A. Morais, Pedro F. N. Souza, Jurandir F. Comar, Valder N. Freire Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis, are associated with an uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Sour...
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 22, 2024 Category: Chemistry Authors: Jackson L. Amaral Source Type: research
Experimental rat models for Hashimoto ’s thyroiditis
ConclusionTwo rat models of autoimmune thyroiditis were obtained. EAT caused in Wistar rats by immunization with rat Tg is similar to Hashimoto ’s thyroiditis. EAT induced with porcine Tg was accompanied by oxyphil cell metaplasia in the parathyroids and hypocalcemia. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 22, 2024 Category: Endocrinology Source Type: research
Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity
Clin Exp Immunol. 2024 Apr 22:uxae036. doi: 10.1093/cei/uxae036. Online ahead of print.ABSTRACTApart from serving as a Th1 lineage commitment regulator, transcription factor T-bet is also expressed in other immune cell types and thus orchestrates their functions. In case of B cells, more specifically, T-bet is responsible for their isotype switching to specific IgG sub-classes (IgG2a/c in mice and IgG1/3 in humans). In various autoimmune disorders, such as systemic lupus erythematosus and/or rheumatoid arthritis, subsets of T-bet expressing B cells, known as age-associated B cells (CD19+CD11c+CD21-T-bet+) and/or double-neg...
Source: Clinical and Developmental Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Athanasios Sachinidis Malamatenia Lamprinou Theodoros Dimitroulas Alexandros Garyfallos Source Type: research
A Case of Palmoplantar Keratoderma in the Constellation of Connective Tissue Diseases
Cureus. 2024 Mar 20;16(3):e56531. doi: 10.7759/cureus.56531. eCollection 2024 Mar.ABSTRACTOverlap syndrome is a clinical challenge and brings together a wide range of treatment options for the treating physician. Addressing each and every complaint of the patient is crucial. A 50-year-old female patient presented with skin thickening, blackening, and hyperkeratosis; dysphagia; joint pain; features of myopathy; Raynaud's phenomenon; and dry mouth. Inflammatory markers were raised along with a positive antinuclear antibody (ANA) with Golgi apparatus pattern, anti-Sjögren's-syndrome-related antigen A (anti-SSA)/Ro60 3+, anti...
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Authors: Ishan Verma Amol H Dube Sunita Kumbhalkar Keshao Nagpure Gitesh Sawatkar Sachin R Chuadhari Ashwini Umredkar Source Type: research
The immunosuppressive drug cyclosporin A has an immunostimulatory function in CD8 < sup > + < /sup > T cells
Eur J Immunol. 2024 Apr 22:e2350825. doi: 10.1002/eji.202350825. Online ahead of print.ABSTRACTCyclosporin A is a well-established immunosuppressive drug used to treat or prevent graft-versus-host disease, the rejection of organ transplants, autoimmune disorders, and leukemia. It exerts its immunosuppressive effects by inhibiting calcineurin-mediated dephosphorylation of the nuclear factor of activated T cells (NFAT), thus preventing its nuclear entry and suppressing T cell activation. Here we report an unexpected immunostimulatory effect of cyclosporin A in activating the mammalian target of rapamycin complex 1 (mTORC1), ...
Source: European Journal of Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Jannis Wi ßfeld Marvin Hering Nora Ten Bosch Guoliang Cui Source Type: research
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis
CONCLUSIONS: Taken together, these findings indicate that PPARG may have a role for distinguishing between RA patients and healthy control, and for distinguishing RA activity; moreover, PPARG could be a novel pharmacological target for alleviating RA through the mediation of autophagy. CBD can act as a PPARG agonist that alleviates the inflammatory progression of RA.PMID:38648706 | DOI:10.1016/j.jaut.2024.103214 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - April 22, 2024 Category: Allergy & Immunology Authors: Qishun Geng Jiahe Xu Xiaoxue Cao Zhaoran Wang Yi Jiao Wenya Diao Xing Wang Zihan Wang Mengxiao Zhang Lu Zhao Lei Yang Tingting Deng Bifa Fan Yuan Xu Lansi Jia Cheng Xiao Source Type: research
Cochlear implantation in patients with autoimmune hearing loss
CONCLUSION: Cochlear implantation can be necessary in some AIED patients and poses a sufficient method for hearing rehabilitation. Depending on the activity of the underlying disease, a rise in impedances may occur. Immunomodulatory treatment may therefore be necessary to maintain adequate hearing results with the CI.PMID:38647666 | DOI:10.1007/s00106-024-01472-5 (Source: HNO)
Source: HNO - April 22, 2024 Category: ENT & OMF Authors: Maximilian Armstorfer Lennart Weitgasser Stefan Tschani Sebastian R ösch Source Type: research
Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017
Acta Oncol. 2024 Apr 21;63:220-228. doi: 10.2340/1651-226X.2024.26182.ABSTRACTBACKGROUND: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%-1%, diagnostic delay: 7-10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce.MATERIALS AND METHODS: A nationwide retrospective register-based study assessing relative risk of cancer - overall and by anatomical site - following HS...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rune Andersen Klaus Rostgaard Ole Pedersen Gregor Borut Ernst Jemec Henrik Hjalgrim Source Type: research
First characterization of major histocompatibility complex class II DRB3 diversity in cattle breeds raised in Egypt
In this study, we characterized BoLA-DRB3 in two local Egyptian populations and one foreign population using polymerase chain reaction-sequence-based typing (PCR-SBT) method. Fifty-four previously reported BoLA-DRB3 alleles and eight new alleles (BoLA-DRB3*005:08, *015:07, *016:03, *017:04, *020:02:02, *021:03, *164:01, and *165:01) were identified. Alignment analysis of the eight new alleles revealed 89.5-98.7 %, and 81.0-97.5 % nucleotide and amino acid identities, respectively, with the BoLA-DRB3 cDNA clone NR-1. Interestingly, BoLA-DRB3 in Egyptian cattle showed a high degree of allelic diversity in native (na = 28, hE...
Source: Gene - April 22, 2024 Category: Genetics & Stem Cells Authors: Rania Hamada Guillermo Giovambattista Samy Metwally Liushiqi Borjigin Meripet Polat Yamanaka Ryosuke Matsuura Alsagher O Ali Hassan Y A H Mahmoud Adel E A Mohamed Kyaw Kyaw Moe Shin-Nosuke Takeshima Satoshi Wada Yoko Aida Source Type: research
Structural basis for the recognition of IFNAR1 by the humanized therapeutic monoclonal antibody QX006N for the treatment of systemic lupus erythematosus
Int J Biol Macromol. 2024 Apr 20:131721. doi: 10.1016/j.ijbiomac.2024.131721. Online ahead of print.ABSTRACTInterferon (IFN) alpha/beta receptor 1 (IFNAR1) is indispensable for antiviral responses and the immune regulation. Dysregulation of the IFNAR1-mediaetd signaling pathways leads to deleterious autoimmune diseases such as systemic lupus erythematosus (SLE). QX006N, a humanized therapeutic monoclonal antibody, specifically targets human IFNAR1 and is in the clinical trial phase for treating SLE, but the molecular mechanism underlying the QX006N-mediated recognition of IFNAR1 remains unclear. Here, we report the high ne...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Xiaorong Chen Huimin Ke Wei Li Lu Yin Wei Chen Tao Chen Yiliang Wu Jiwan Qiu Wei Feng Source Type: research
