The unique interplay between antinuclear antibodies and nuclear molecules in the pathogenesis of SLE
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and causes a wide range of inflammatory manifestations. The hallmark of SLE is the production of antibodies to components of the cell nucleus (antinuclear antibodies or ANAs). These antibodies can bind to DNA, RNA and protein complexes with nucleic acids. Among ANAs, antibodies to DNA (anti-DNA) are markers for classification and disease activity, waxing and waning in many patients. In the blood, anti-DNA antibodies can bind DNA to form immune complexes with two distinct roles in pathogenesis: renal deposition to provok...
Source: Arthritis and Rheumatology - April 16, 2024 Category: Rheumatology Authors: David S. Pisetsky Tags: Review Source Type: research
The Epidemiology of Hospital-Treated Alopecia Areata in Denmark, 1995 –2016
ConclusionThis cohort study reported incidence rates and prevalence over time and characteristics of individuals with hospital-treated AA in Denmark, which are in agreement with those previously reported in this population. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 16, 2024 Category: Dermatology Source Type: research
Molecules, Vol. 29, Pages 1803: A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease
In conclusion, our findings reported a novel IRAK4 inhibitor, DW18134, as a promising candidate for treating inflammatory diseases, including peritonitis and IBD. (Source: Molecules)
Source: Molecules - April 16, 2024 Category: Chemistry Authors: Yuqing Huang Yi Ning Zhiwei Chen Peiran Song Haotian Tang Wenhao Shi Zhipeng Wan Gege Huang Qiupei Liu Yun Chen Yu Zhou Yuantong Li Zhengsheng Zhan Jian Ding Wenhu Duan Hua Xie Tags: Article Source Type: research
Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation
ConclusionsThe quantitative measurement system for M2BPGi depends on liver fibrosis and inflammation, regardless of etiology. Liver inflammation complicates the interpretation of M2BPGi-Qt results when assessing the fibrosis stage. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - April 16, 2024 Category: Gastroenterology Source Type: research
The Epidemiology of Hospital-Treated Alopecia Areata in Denmark, 1995 –2016
ConclusionThis cohort study reported incidence rates and prevalence over time and characteristics of individuals with hospital-treated AA in Denmark, which are in agreement with those previously reported in this population. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 16, 2024 Category: Dermatology Source Type: research
Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals
CONCLUSION These findings suggest that nAIGAs are isolated and that their penetrance in HLA-DRB1*15:02 or 16:02 individuals is low, implying that they may be triggered by rare germline or somatic variants. In contrast, the risk of mycobacterial disease in patients with nAIGAs is high, confirming that these nAIGAs are the cause of EM disease.FUNDING The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI095983 and U19AIN1625568), the National Center for Advancing Translati...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Jessica N. Peel, Rui Yang, Tom Le Voyer, Adrian Gervais, Jérémie Rosain, Paul Bastard, Anish Behere, Axel Cederholm, Aaron Bodansky, Yoann Seeleuthner, Clément Conil, Jing-Ya Ding, Wei-Te Lei, Lucy Bizien, Camille Soudee, Mélanie Migaud, Masato Ogishi Source Type: research
Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database
ConclusionTogether,EPSTI1 was found to be a potential biomarker for SLE, closely related to T cell immune imbalance.Key Points• EPSTI1 expression was significantly increased in PBMCs of SLE patients.• EPSTI1 was positively correlated with disease activity and T cell activation- or differentiation-associated genes in SLE patients.• EPSTI1 might have a good diagnostic value for SLE. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Multiparametric ultrasound as a new concept of assessment of liver tissue damage
World J Gastroenterol. 2024 Mar 28;30(12):1663-1669. doi: 10.3748/wjg.v30.i12.1663.ABSTRACTLiver disease accounts for approximately 2 million deaths per year worldwide. All chronic liver diseases (CLDs), whether of toxic, genetic, autoimmune, or infectious origin, undergo typical histological changes in the structure of the tissue. These changes may include the accumulation of extracellular matrix material, fats, triglycerides, or tissue scarring. Noninvasive methods for diagnosing CLD, such as conventional B-mode ultrasound (US), play a significant role in diagnosis. Doppler US, when coupled with B-mode US, can be helpful...
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Angela Peltec Ioan Sporea Source Type: research
Multiparametric ultrasound as a new concept of assessment of liver tissue damage
World J Gastroenterol. 2024 Mar 28;30(12):1663-1669. doi: 10.3748/wjg.v30.i12.1663.ABSTRACTLiver disease accounts for approximately 2 million deaths per year worldwide. All chronic liver diseases (CLDs), whether of toxic, genetic, autoimmune, or infectious origin, undergo typical histological changes in the structure of the tissue. These changes may include the accumulation of extracellular matrix material, fats, triglycerides, or tissue scarring. Noninvasive methods for diagnosing CLD, such as conventional B-mode ultrasound (US), play a significant role in diagnosis. Doppler US, when coupled with B-mode US, can be helpful...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Angela Peltec Ioan Sporea Source Type: research
Oncology: What You May Have Missed in 2023
This article highlights important publications from 2023 on topics across a wide spectrum relating to the management of oncology patients. The literature was screened for significant new evidence that is relevant to internal medicine specialists and subspecialists whose focus is not oncology. Two articles address the importance of social interventions targeting end-of-life care for low-income and minority patients and the well-being of caregivers. Two additional articles address screening considerations in patients at risk for colorectal and lung cancer. Two more articles address safe use of hormone-related therapies to tr...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Courtney H Coschi Lorin Dodbiba DuPont Guerry Source Type: research
When rare diseases crisscross within the same patient: von Hippel-Lindau and type 1 gastric neuroendocrine tumor
Hormones (Athens). 2024 Apr 15. doi: 10.1007/s42000-024-00556-9. Online ahead of print.ABSTRACTVon-Hippel-Lindau (VHL) is a genetic multisystem disorder characterized by visceral cysts and benign and malignant tumors in various organs. Herein, we present the case of a 23-year-old woman with VHL presenting with multiple gastric neuroendocrine neoplasms (gNENs) type 1 in the context of chronic autoimmune gastritis (CAG). Although gNENs are not acknowledged as a typical entity in VHL patients, in the present case, gNENs were composed of neoplastic cells with clear cytoplasm usually seen in tumors related to VHL disease. We ad...
Source: Hormones - April 15, 2024 Category: Endocrinology Authors: Krystallenia I Alexandraki Ariadni Spyroglou Paraskevi Xekouki Konstantinos I Bramis Georgios Kyriakopoulos Konstantinos Barkas Ioannis S Papanikolaou George Mastorakos Manousos Konstadoulakis Source Type: research
Association Between Iodine Status and Prevalence of Hypothyroidism, Autoimmune Thyroiditis, and Thyroid Nodule: a Cross-Sectional Study in Shandong Province, China
This study identified associations between different UIC levels and the prevalence of thyroid disorders, with low UIC (< 100 μg/L) posing a risk for TN, and the detection rate of TN and hypothyroidism was the lowest in UIC (200-299 μg/L) group. Therefore, the acceptable UIC range of 'adequate' iodine intake among adults can be widened from 100-199 µg/L to 100-299 µg/L.PMID:38619679 | DOI:10.1007/s12011-024-04179-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 15, 2024 Category: Biology Authors: Fangang Meng Peng Liu Yang Du Jinyin Yao Lijun Fan Chunpeng Lv Yi Chen Xianglan Chen Wen Jiang Wei Zhang Dianjun Sun Source Type: research
Isolation and Single-Cell Transcriptomic Analysis of Murine Regulatory B Cells
Methods Mol Biol. 2024;2782:159-166. doi: 10.1007/978-1-0716-3754-8_12.ABSTRACTRegulatory B (Breg) cells have been demonstrated to play an important role in the inhibition of a wide range of immunological responses, and they are absent or malfunction in autoimmune diseases like lupus. Breg cells can control immunological responses and keep the immune system in a balanced state by releasing immunosuppressive cytokines such as transforming growth factor-beta (TGF-β) and interleukin-10 (IL-10), which in turn promote regulatory T (Treg) cells and reduce effector T cell responses. Breg cells have also been linked to the modula...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Razan M Alajoleen Liwu Li Xin M Luo Source Type: research
Oncology: What You May Have Missed in 2023
This article highlights important publications from 2023 on topics across a wide spectrum relating to the management of oncology patients. The literature was screened for significant new evidence that is relevant to internal medicine specialists and subspecialists whose focus is not oncology. Two articles address the importance of social interventions targeting end-of-life care for low-income and minority patients and the well-being of caregivers. Two additional articles address screening considerations in patients at risk for colorectal and lung cancer. Two more articles address safe use of hormone-related therapies to tr...
Source: Cancer Control - April 15, 2024 Category: Cancer & Oncology Authors: Courtney H Coschi Lorin Dodbiba DuPont Guerry Source Type: research
