Diagnostic Value of Krebs von den Lungen (KL-6) for Interstitial Lung Disease: A European Prospective Cohort
CONCLUSION: Serum KL-6 values greater than 465U/mL have excellent sensitivity and specificity for detecting ILD in our Spanish cohort. Multicentre studies are needed to validate our results.PMID:38644152 | DOI:10.1016/j.arbres.2024.03.028 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - April 21, 2024 Category: Respiratory Medicine Authors: Paloma Millan-Billi Iv án Castellví Laura Martinez-Martinez Anais Mariscal Silvia Barril Miriana D'Alessandro Tom ás Franquet Diego Castillo Source Type: research
Autoimmune encephalitis: what the radiologist needs to know
AbstractAutoimmune encephalitis is a relatively novel nosological entity characterized by an immune-mediated damage of the central nervous system. While originally described as a paraneoplastic inflammatory phenomenon affecting limbic structures, numerous instances of non-paraneoplastic pathogenesis, as well as extra-limbic involvement, have been characterized. Given the wide spectrum of insidious clinical presentations ranging from cognitive impairment to psychiatric symptoms or seizures, it is crucial to raise awareness about this disease category. In fact, an early diagnosis can be dramatically beneficial for the progno...
Source: Neuroradiology - April 20, 2024 Category: Radiology Source Type: research
Disrupting B and T cell Collaboration in Autoimmune Disease: T cell engagers versus CAR T cell therapy?
Clin Exp Immunol. 2024 Apr 20:uxae031. doi: 10.1093/cei/uxae031. Online ahead of print.ABSTRACTB and T cells collaborate to drive autoimmune disease (AID). Historically, B and T cell (B-T cell) co-interaction was targeted through different pathways such as alemtuzumab, abatacept, and dapirolizumab with variable impact on B cell depletion (BCD), whereas the majority of patients with AID including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and organ transplantation benefit from targeted BCD with anti-CD20 monoclonal antibodies such as rituximab, ocrelizumab or ofatumumab. Refractory AID is a signi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Kavina Shah Maria Leandro Mark Cragg Florian Kollert Franz Schuler Christian Klein Venkat Reddy Source Type: research
The CD318/CD6 axis limits type 1 diabetes islet autoantigen-specific human T cell activation
J Autoimmun. 2024 Apr 19;146:103228. doi: 10.1016/j.jaut.2024.103228. Online ahead of print.ABSTRACTCD6 is a glycoprotein expressed on CD4 and CD8 T cells involved in immunoregulation. CD318 has been identified as a CD6 ligand. The role of CD318 in T cell immunity is restricted as it has only been investigated in a few mice autoimmune models but not in human diseases. CD318 expression was thought to be limited to mesenchymal-epithelial cells and, therefore, contribute to CD6-mediated T cell activation in the CD318-expressing tissue rather than through interaction with antigen-presenting cells. Here, we report CD318 express...
Source: Journal of Autoimmunity - April 20, 2024 Category: Allergy & Immunology Authors: Jeong-Su Do David Arribas-Layton Jemily Juan Isaac Garcia Sindhu Saraswathy Meirigeng Qi Enrique Montero Helena Reijonen Source Type: research
Relevance of acquired T cell molecular defects in the immunopathogenesis of SLE
Clin Immunol. 2024 Apr 18:110225. doi: 10.1016/j.clim.2024.110225. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary factors and have therefore been considered secondary to the disease process itself. Here, we contextualize some of t...
Source: Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Florencia Rosetti Iris K Madera-Salcedo Jos é C Crispín Source Type: research
A new era of antibody discovery: an in-depth review of AI-driven approaches
Drug Discov Today. 2024 Apr 18:103984. doi: 10.1016/j.drudis.2024.103984. Online ahead of print.ABSTRACTGiven their high affinity and specificity for a range of macromolecules, antibodies are widely used in the treatment of autoimmune diseases, cancers, inflammatory diseases, and Alzheimer's disease (AD). Traditional experimental methods are time-consuming, expensive, and labor-intensive. Recent advances in artificial intelligence (AI) technologies provide complementary methods that can reduce the time and costs required for antibody design by minimizing failures and increasing the success rate of experimental tests. In th...
Source: Drug Discovery Today - April 20, 2024 Category: Drugs & Pharmacology Authors: Jin Cheng Tianjian Liang Xiang-Qun Xie Zhiwei Feng Li Meng Source Type: research
Tumor necrosis factor alpha induced protein 3, interleukin 10, tumor necrosis factor alpha, and interleukin 17 F genes polymorphisms in Algerian patients with rheumatoid arthritis
CONCLUSION: Our results show that there is a tendency for the AG genotype of IL10-1082 to be associated with the production of ACPA in patients with RA. None of the variants studied were associated with RA susceptibility in Algerians.PMID:38642181 | DOI:10.1007/s11033-024-09525-2 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: D Benahmed M Abbadi D Zaoui H Ait Hamoudi W Boukouaci S Bouguerra-Aouichat S S Salah Source Type: research
A new era of antibody discovery: an in-depth review of AI-driven approaches
Drug Discov Today. 2024 Apr 18:103984. doi: 10.1016/j.drudis.2024.103984. Online ahead of print.ABSTRACTGiven their high affinity and specificity for a range of macromolecules, antibodies are widely used in the treatment of autoimmune diseases, cancers, inflammatory diseases, and Alzheimer's disease (AD). Traditional experimental methods are time-consuming, expensive, and labor-intensive. Recent advances in artificial intelligence (AI) technologies provide complementary methods that can reduce the time and costs required for antibody design by minimizing failures and increasing the success rate of experimental tests. In th...
Source: Drug Discovery Today - April 20, 2024 Category: Drugs & Pharmacology Authors: Jin Cheng Tianjian Liang Xiang-Qun Xie Zhiwei Feng Li Meng Source Type: research
Long-term remission of candidiasis with fermented lingonberry mouth rinse in an adult patient with APECED.
APECED, or autoimmune polyendocrine syndrome type 1 (APS-1), is a disease caused by mutations in the autoimmune regulator (AIRE) gene [1]. The consequent impaired immune responses formation of organ-specific autoantibodies (AABs). Disorder manifestations are broad, including organ-specific autoimmunity and chronic mucocutaneous candidiasis (CMC) [2]. Patients need lifelong follow-up and hormone replacement therapy. T helper 17 (Th17)-type adaptive immune response is crucial in the mucosal defense against Candida infections [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 20, 2024 Category: Infectious Diseases Authors: Pirjo P ärnänen, Juho Suojanen, Mikael Laine, Timo Sorsa, Annamari Ranki Tags: Case Report Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis
In this study, we investigated the role of liver kinase B1 (Lkb1), a serine/threonine kinase that links cellular metabolism with cell growth and proliferation, in γδ T-cell biology. Our findings demonstrate that Lkb1 is not only involved in regulating γδ T lineage commitment but also plays a critical role in γδ T-cell effector function. Specifically, T-cell-specific deletion of Lkb1 resulted in impaired thymocyte development and distinct alterations in γδ T-cell subsets in both the thymus and peripheral lymphoid tissues. Notably, loss of Lkb1 inhibited the commitment of Vγ1 and Vγ4 γδ T cells, promoted the matu...
Source: Cellular and Molecular Immunology - April 19, 2024 Category: Molecular Biology Authors: Zhiqiang Xiao Shanshan Wang Liang Luo Wenkai Lv Peiran Feng Yadong Sun Quanli Yang Jun He Guangchao Cao Zhinan Yin Meixiang Yang Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Palliating Undifferentiated Encephalopathy in Creutzfeldt-Jakob Disease vs. Autoimmune Encephalitis
1. Utilizing a case based approach, learners will be able to describe the pathophysiology of Creutzfeldt-Jakob Disease (CJD) and autoimmune encephalitis (AE) that predicts the challenges of managing delirium and agitation.2. Learners will be able to recognize the nuances of undifferentiated encephalopathy in order to mitigate potential harms of an indiscriminate approach to neurocognitive palliation with potent dopaminergic antagonists and consider a more sophisticated approach with second generation antipsychotics possessing less dopaminergic antagonism. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Christy Meyer, Cayman Martin, Natsu Fukui Source Type: research
Current status of fertility preservation in a Spanish tertiary public hospital: multidisciplinary approach and experience in over 1500 patients
ConclusionsThe increase in FP treatment reflects the implementation of reproductive counselling in oncology programmes. A multidisciplinary approach in a tertiary public hospital allows individualised FP treatment for each patient. In recent years, there has been a change in trend with the introduction of new indications for FP and a change in techniques due to their optimisation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
