Homotherapy for heteropathy: Interleukin-41 and its biological functions
Immunology. 2024 Apr 9. doi: 10.1111/imm.13791. Online ahead of print.ABSTRACTInterleukin-41 (IL-41) is a newly discovered cytokine, named Cometin, Subfatin, meteorin-like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti-inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Grav...
Source: Immunology - April 10, 2024 Category: Allergy & Immunology Authors: Runfeng Shi Meixin He Yongzheng Peng Xu Xia Source Type: research
GSE248626 Double-negative T cells ameliorate psoriasis by selectively inhibition on IL-17A producing γδ T cells
In this study, we aimed to evaluate the protection of DNT cells and explore its underlying mechanism. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity
In conclusion, our data show that, lowC4A copy number and higher insertion ofHERV-K inC4A increases the risk for SLE.C4 andC4-HERV CNs did not correlate with serum complements, autoantibodies, disease phenotypes and activity in SLE. Further validation in a larger homogenous SLE cohort is needed. (Source: Immunologic Research)
Source: Immunologic Research - April 10, 2024 Category: Allergy & Immunology Source Type: research
Unlocking the Potential of Extracellular Vesicles as the Next Generation Therapy: Challenges and Opportunities
Conclusion:From this perspective, this review delves into the advantages and challenges associated with employing MSC –EVs in clinical settings, with a specific focus on their potential in treating conditions like lung diseases, cancer, and autoimmune disorders. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - April 10, 2024 Category: Biotechnology Source Type: research
Personalized treatment concepts in extraocular cancer
CONCLUSIONS: The optimal treatment for periocular skin cancer depends on the type and size of the tumor and whether it involves orbital and adnexal structures. Adjuvant and neoadjuvant therapy with chemotherapy-targeted therapies and immune checkpoint inhibitors should be considered based on tumor type, tumor molecular profile, expected response rate, and candidacy for systemic treatment.PMID:38590555 | PMC:PMC10999489 | DOI:10.1016/j.aopr.2024.02.003 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Sitong Ju Alexander C Rokohl Yongwei Guo Ke Yao Wanlin Fan Ludwig M Heindl Source Type: research
Significantly Elevated CA 19-9 after COVID-19 Vaccination and Literature Review of Non-Cancerous Cases with CA 19-9 & gt; 1000 U/mL
CONCLUSIONS: Conducting differential diagnosis, it should not be forgotten that most international guidelines recommend the use of CA 19-9 only in conjunction with pathology of pancreas in radiological imaging; however, even such a combination can point the diagnostic pathway in the wrong direction. A highly elevated CA 19-9 level, typically associated with PDAC, may be the result of benign disease including AIP related to COVID-19 vaccination.PMID:38592088 | DOI:10.3390/jcm13051263 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Jakub Ciesielka Krzysztof Jakim ów Natalia Tekiela Laura Peisert Anna Kwa śniewska Dariusz Kata Jerzy Chudek Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Vigeo attenuates cartilage and bone destruction in a collagen ‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines
Exp Ther Med. 2024 Mar 19;27(5):208. doi: 10.3892/etm.2024.12496. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease characterized by articular cartilage destruction, bone destruction and synovial hyperplasia. It has been suggested that Vigeo, a mixture of Eleutherococcus senticosus, Achyranthes japonica and Atractylodes japonica fermented with Korean nuruk, has an anti-osteoporotic effect in a mouse model of inflammation-mediated bone loss. The present study evaluated the therapeutic effects of Vigeo in RA using a collagen-induced arthritis (CIA) mouse model. DBA/1J mi...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yoon-Hee Cheon Chang Hoon Lee So Young Eun Gyeong Do Park Chong Hyuk Chung Ju-Young Kim Myeung Su Lee Source Type: research
A study of the molecular mechanism of action of Jiawei Guizhishaoyaozhimu Decoction during rheumatoid arthritis therapy based on basic of network pharmacology and experimental verification
Exp Ther Med. 2024 Mar 20;27(5):212. doi: 10.3892/etm.2024.12499. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease, which primarily affects the joints. The aim of the present study was to predict the main active ingredients of Jiawei Guizhishaoyaozhimu Decoction (JWGZSYZMD) and potential targets of this treatment during RA therapy by using molecular docking and network pharmacology methods. In addition, another aim was to investigate the therapeutic effects and mechanism of JWGZSYZMD on joint inflammation in rat models of collagen Ⅱ-induced arthritis (CIA). JWGZSYZMD ingredients and ...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yiji Cheng Yue Ji Kaidi Feng Xinyuan Zhang Yunming Xiao Weixia Jing Source Type: research
Role of co ‑inhibitory molecules in the treatment of psoriasis (Review)
Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May.ABSTRACTPsoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in the pathogenesis of psoriasis. While T-cell activation not only requires the first recognition of T-cell receptor and major histocompa...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yue Yao Linxi Zeng Xin Huang Jinfang Zhang Guoqiang Zhang Ling Wang Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Significantly Elevated CA 19-9 after COVID-19 Vaccination and Literature Review of Non-Cancerous Cases with CA 19-9 & gt; 1000 U/mL
CONCLUSIONS: Conducting differential diagnosis, it should not be forgotten that most international guidelines recommend the use of CA 19-9 only in conjunction with pathology of pancreas in radiological imaging; however, even such a combination can point the diagnostic pathway in the wrong direction. A highly elevated CA 19-9 level, typically associated with PDAC, may be the result of benign disease including AIP related to COVID-19 vaccination.PMID:38592088 | PMC:PMC10932348 | DOI:10.3390/jcm13051263 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Jakub Ciesielka Krzysztof Jakim ów Natalia Tekiela Laura Peisert Anna Kwa śniewska Dariusz Kata Jerzy Chudek Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Incidence and disease burden of autoimmune inflammatory rheumatic diseases after non ‐pharmaceutical interventions in the COVID‐19 era: A nationwide observational study in Korea
ConclusionImplementation of NPIs to contain the pandemic led to a reduction in the incidence of SLE and changed patterns of medical care utilization and treatment cost for most AIRDs. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 9, 2024 Category: Rheumatology Authors: Je Hee Shin,
Jung Yoon Pyo,
Minkyung Han,
Myeongjee Lee,
Sung Min Lim,
Jee Yeon Baek,
Ji Young Lee,
Ji ‐Man Kang,
InKyung Jung,
Jong Gyun Ahn Tags: ORIGINAL ARTICLE Source Type: research
