A case of multiple autoimmune syndrome comprising autoimmune thyroid disease, vitiligo, morphea, and lichen sclerosus
We report a unique case of a 55-year-old female patient that presented with four autoimmune diseases: autoimmune thyroid disease, vitiligo, morphea, and lichen sclerosus. She was evaluated for progression of morphea and lichen sclerosus, and we confirmed histopathological overlapping of these two diseases in the same lesion. We discuss the increasing prevalence of autoimmune diseases and similar case reports on dermatological polyautoimmunity.PMID:38606648 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - April 12, 2024 Category: Dermatology Authors: Hana Ga šper Vesna Breznik Source Type: research
Thyroidectomy for Euthyroid Patients with Hashimoto Disease and Persistent Symptoms: An Observational, Postrandomization Study
CONCLUSIONS: Thyroidectomy had a beneficial symptom-reducing effect in euthyroid patients with Hashimoto disease and persistent symptoms. The pathophysiology of residual symptoms remains unclear, and surgical complication rates are high. If thyroidectomy is considered as a treatment option, it should be performed in dedicated centers with experienced endocrine surgeons and as part of further studies on persistent symptoms. This trial is registered with NCT-02319538.PMID:38606313 | PMC:PMC11008973 | DOI:10.1155/2024/5518720 (Source: Journal of Thyroid Research)
Source: Journal of Thyroid Research - April 12, 2024 Category: Endocrinology Authors: Geir Hoff Tomm Bernklev Lene Johnsen Laurens Reitsma Dirk Sina Andromeda Lauzike Charlotte Gibbs Tone Hoel Lende Jon Kristian Narvestad Rasmus Kildahl Roald Omdal Jan Terje Kval øy H åvard Søiland Source Type: research
Promotion of 14-3-3 ζ/Heme Oxygenase-1 Axis on Endotoxin-Induced Uveitis and Microglia Ferroptosis in Mice
CONCLUSION: The study provides valuable insights into the mechanisms underlying uveitis and highlights the potential of the 14-3-3ζ/HO-1 axis as a therapeutic target for the disease. Further research in this area could lead to the development of preventive and therapeutic strategies for uveitis.PMID:38607656 | DOI:10.1080/09273948.2024.2328784 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 12, 2024 Category: Allergy & Immunology Authors: Mohan Li Sijia Gao Yu Wen Liang Yong Liming Tao Source Type: research
CRISPR-Cas9 applications in T cells and adoptive T cell therapies
Cell Mol Biol Lett. 2024 Apr 12;29(1):52. doi: 10.1186/s11658-024-00561-1.ABSTRACTT cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different immune challenges dependent on antigen stimulation levels, metabolic conditions, and the degree of inflammation. T cell-based therapeutic strategies are gaining widespread adoption in oncology and treating inflammatory conditions. Emerging researches reveal that clustered regularly interspaced palindromic repeats-associated protein 9 (C...
Source: Cellular and Molecular Biology Letters - April 12, 2024 Category: Biochemistry Authors: Xiaoying Chen Shuhan Zhong Yonghao Zhan Xuepei Zhang Source Type: research
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development
Cell Stem Cell. 2024 Apr 4:S1934-5909(24)00092-4. doi: 10.1016/j.stem.2024.03.011. Online ahead of print.ABSTRACTAutonomic parasympathetic neurons (parasymNs) control unconscious body responses, including "rest-and-digest." ParasymN innervation is important for organ development, and parasymN dysfunction is a hallmark of autonomic neuropathy. However, parasymN function and dysfunction in humans are vastly understudied due to the lack of a model system. Human pluripotent stem cell (hPSC)-derived neurons can fill this void as a versatile platform. Here, we developed a differentiation paradigm detailing the derivation of func...
Source: Cell Stem Cell - April 12, 2024 Category: Stem Cells Authors: Hsueh-Fu Wu Kenyi Saito-Diaz Chia-Wei Huang Jessica L McAlpine Dong Eun Seo D Sumner Magruder Mohamed Ishan Harrison C Bergeron William H Delaney Fabio R Santori Smita Krishnaswamy Gerald W Hart Ya-Wen Chen Robert J Hogan Hong-Xiang Liu Natalia B Ivanova Source Type: research
A Rare Case of Benign Recurrent Intrahepatic Cholestasis Initially Diagnosed in Middle-age
CONCLUSION: The comprehensive diagnosis of a middle-aged male patient with BRIC-2, which involved extensive radiological, hematological, and genetic investigations, informed a tailored tapering prednisone regimen, highlighting the importance of personalized medicine in managing atypical presentations of this rare cholestatic disorder.PMID:38607191 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Fang Liu Wei Li Ming-Gang Zhang Zhen-Mei Song Xiao-di Wang Xiu-Hong Wang Shi-Yu Du Source Type: research
A case of multiple autoimmune syndrome comprising autoimmune thyroid disease, vitiligo, morphea, and lichen sclerosus
We report a unique case of a 55-year-old female patient that presented with four autoimmune diseases: autoimmune thyroid disease, vitiligo, morphea, and lichen sclerosus. She was evaluated for progression of morphea and lichen sclerosus, and we confirmed histopathological overlapping of these two diseases in the same lesion. We discuss the increasing prevalence of autoimmune diseases and similar case reports on dermatological polyautoimmunity.PMID:38606648 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - April 12, 2024 Category: Dermatology Authors: Hana Ga šper Vesna Breznik Source Type: research
Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis
ConclusionThis case demonstrates that BoDV-1 ELISpot serves as additional diagnostic tool even in the first week after hospitalisation of patients with BoDV-1 encephalitis. (Source: Infection)
Source: Infection - April 12, 2024 Category: Infectious Diseases Source Type: research
Advancing precision rheumatology through tissue and blood profiling
Nature Reviews Rheumatology, Published online: 12 April 2024; doi:10.1038/s41584-024-01115-7Multidimensional and single-cell profiling of peripheral blood and inflamed tissues is a powerful and high-resolution tool for the stratification of patients with autoimmune rheumatic diseases into distinct cellular and/or molecular endotypes. The road towards precision rheumatology is long, but the time has come to enter the territory of clinical validation. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - April 12, 2024 Category: Rheumatology Authors: George D. Kalliolias Athanasios G. Papavassiliou Source Type: research
Experimental Animal Models for IC/BPS
AbstractPurpose of ReviewInterstitial cystitis/bladder pain syndrome (IC/BPS) is a disease that causes bladder symptoms such as pelvic pain and frequent urination and is often an intractable disease affecting a patient ’s quality of life. The etiology of IC/BPS remains elusive, and treatment strategies are still not fully established. To better understand the underlying pathophysiology, many studies have strived to recreate an animal model of IC/BPS to help further expand the treatment options of this difficult disease.Recent FindingsBasic animal studies of IC/BPS have often been conducted by provoking inflammation in th...
Source: Current Bladder Dysfunction Reports - April 12, 2024 Category: Urology & Nephrology Source Type: research
Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis
ConclusionThis case demonstrates that BoDV-1 ELISpot serves as additional diagnostic tool even in the first week after hospitalisation of patients with BoDV-1 encephalitis. (Source: Infection)
Source: Infection - April 12, 2024 Category: Infectious Diseases Source Type: research
Examination of the shared genetic architecture between multiple sclerosis and systemic lupus erythematosus facilitates discovery of novel lupus risk loci
AbstractSystemic Lupus Erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations, including neurological and psychiatric symptoms. Genetic association studies in SLE have been hampered by insufficient sample size and limited power compared to many other diseases. Multiple Sclerosis (MS) is a chronic relapsing autoimmune disease of the central nervous system (CNS) that also manifests neurological and immunological features. Here, we identify a method of leveraging large-scale genome wide association studies (GWAS) in MS to identify novel genetic risk loci in SLE. Statistical genetic comparison methods i...
Source: Human Genetics - April 12, 2024 Category: Genetics & Stem Cells Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis
CONCLUSION: Altogether, these data unveil a crosstalk between intestinal and central inflammation in EAE and support the use of molecular MRI of intestinal MAdCAM-1 as a new biomarker for prognostic in MS patients.PMID:38604270 | DOI:10.1016/j.bbi.2024.04.006 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - April 11, 2024 Category: Neurology Authors: Erwan Baudron Sara Martinez de Lizarrondo Maxime Gauberti Barbara Delaunay-Piednoir Antoine P Fournier Denis Vivien Fabian Docagne Isabelle Bardou Source Type: research
Cancers, Vol. 16, Pages 1462: The Challenge for a Correct Diagnosis of Refractory Thrombocytopenia: ITP or MDS with Isolated Thrombocytopenia?
nidis
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated thrombocytopenia. It is diagnosed in patients with a platelet count below 100,000 per cubic millimeter in whom other causes of thrombocytopenia have been ruled out, and its diagnosis is generally one of exclusion. Clinical manifestations of patients may vary from asymptomatic disease to mild mucocutaneous or life-threatening bleeding. Glucocorticoids are used as first-line treatment for ITP, while other second-line medications, mainly thrombopoietin-receptor agonists (TPO-RA) and rituximab, are given to patients in whom ITP does not ...
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Aikaterini Kosmidou Eleni Gavriilaki Athanasios Tragiannidis Tags: Review Source Type: research
